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Monocyte deactivation in septic patients: Restoration by IFN-γ treatment

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Recombinant Human Interleukin 1 Receptor Antagonist in the Treatment of Patients With Sepsis Syndrome

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Recombinant human interleukin 1 receptor antagonist in the treatment of patients with sepsis syndrome. Results from a randomized, double-blind, placebo-controlled trial. Phase III rhIL-1ra Sepsis Syndrome Study Group

inferredcites →https://doi.org/10.1002/jlb.58.4.373openalex-snapshot

Role of interferon-γ in immune cell regulation

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Host Defense Dysfunction in Trauma, Shock and Sepsis

inferredcites →https://doi.org/10.1007/978-3-642-77405-8_40openalex-snapshot

Alterations in Function and Phenotype of Monocytes from Patients with Septic Disease: Predictive Value and New Therapeutic Strategies

inferredcites →https://doi.org/10.1016/0092-8674(93)90134-copenalex-snapshot

Mice deficient for the 55 kd tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L. monocytogenes infection

inferredcites →https://doi.org/10.1056/nejm199606273342603openalex-snapshot

Treatment of Septic Shock with the Tumor Necrosis Factor Receptor:Fc Fusion Protein

inferredcites →https://doi.org/10.1084/jem.181.5.1887openalex-snapshot

Mechanism of endotoxin desensitization: involvement of interleukin 10 and transforming growth factor beta.

inferredcites →https://doi.org/10.1093/intimm/7.4.517openalex-snapshot

Up-regulation of monocytic IL-10 by tumor necrosis factor-α and cAMP elevating drugs

inferredcites →https://doi.org/10.1097/00000658-199109000-00009openalex-snapshot

Immunomodulatory Therapy With Thymopentin and Indomethacin

inferredcites →https://doi.org/10.1097/00003246-199607000-00010openalex-snapshot

Sir Isaac Newton, sepsis, SIRS, and CARS

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Diagnostic value of an immune monitoring program for the clinical management of immunosuppressed patients with septic complications

inferredcites →https://doi.org/10.1126/science.3895437openalex-snapshot

Passive Immunization Against Cachectin/Tumor Necrosis Factor Protects Mice from Lethal Effect of Endotoxin

inferredcites →https://doi.org/10.1172/jci115493openalex-snapshot

Dysregulation of in vitro cytokine production by monocytes during sepsis.

inferredcites →https://doi.org/10.1378/chest.101.6.1644openalex-snapshot

Definitions for Sepsis and Organ Failure and Guidelines for the Use of Innovative Therapies in Sepsis

inferredcites →https://doi.org/10.4049/jimmunol.145.11.3762openalex-snapshot

Requirement of endogenous tumor necrosis factor/cachectin for recovery from experimental peritonitis.

inferredcites →https://doi.org/10.4049/jimmunol.145.9.2920openalex-snapshot

The role of IFN-gamma in the pathology of experimental endotoxemia.

inferredcites →https://doi.org/10.4049/jimmunol.155.3.1420openalex-snapshot

Inhibition of IL-10 expression by IFN-γ up-regulates transcription of TNF-α in human monocytes

inferredcites →https://doi.org/10.7326/0003-4819-120-9-199405010-00009openalex-snapshot

Selected Treatment Strategies for Septic Shock Based on Proposed Mechanisms of Pathogenesis

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Towards Personalized Immunotherapy in Sepsis: The PROVIDE Randomized Clinical Trial

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Decreased Cytokine Expression in Peripheral Blood Leukocytes of Patients With Severe Sepsis

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Immunosuppression in Patients Who Die of Sepsis and Multiple Organ Failure

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Monocyte deactivation and its reversal in a patient with chemotherapy-induced leukopenia and severe systemic infection

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Determination of CD4 antigen density on cells: Role of antibody valency, avidity, clones, and conjugation

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The Th1 and Th2 cytokines IFN-γ and IL-4 antagonize the inhibition of monocyte IL-1 receptor antagonist by glucocorticoids: involvement of IL-1

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Potent suppression of IL-12 production from monocytes and dendritic cells during endotoxin tolerance

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Culture of bone marrow cells in GM-CSF plus high doses of lipopolysaccharide generates exclusively immature dendritic cells which induce alloantigen- specific CD4 T cell anergyin vitro

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Performance evaluation of quantiBRITE phycoerythrin beads

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Expression of MHC class II molecules contributes to lipopolysaccharide responsiveness

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Flow cytometric analysis of peripheral blood dendritic cells in patients with severe sepsis

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Inter‐laboratory assessment of flow cytometric monocyte HLA‐DR expression in clinical samples

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Bicentric evaluation of stabilizing sampling tubes for assessment of monocyte HLA‐DR expression in clinical samples

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Whole blood no‐lyse no‐wash micromethod for the quantitative measurement of monocyte HLA‐DR

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P2X7 nucleotide receptor: Modulation of LPS‐induced macrophage signaling and mediator production

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Genetic deletion of the HIF ‐1α isoform I.1 in T cells enhances antibacterial immunity and improves survival in a murine peritonitis model

inferred← citeshttps://doi.org/10.1002/emmm.201303503openalex-snapshot

Microparticle alpha‐2‐macroglobulin enhances pro‐resolving responses and promotes survival in sepsis

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Immunomodulatory Nanozymes Eradicate Intracellular Infections and Rescue Immunoparalysis for Treating Multidrug‐Resistant Bacterial Sepsis

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Reduced monocyte HLA-DR expression: A novel biomarker of disease severity and outcome in acetaminophen-induced acute liver failure

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Impaired monocyte‐macrophage functions and defective toll‐like receptor signaling in hepatitis E virus‐infected pregnant women with acute liver failure

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Identification of SORT1 as a Key Regulator of Antigen Presentation in CD16+ Monocytes During Septic Shock via Multi‐Omics and In Silico Gene Knockout Analysis

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Ventilation‐Induced Lung Injury

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From Molecular Mechanisms of the Pathogenesis of Sepsis to the Novel Healing Biomolecules: Recent Progressions in Dealing With Sepsis

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Long-term reprogramming of the innate immune system

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Immunonutrition in Critical Illness: What Is the Role?

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Pathways mediating resolution of inflammation: when enough is too much

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The holy basil administration diminishes the NF‐kB expression and protects alveolar epithelial cells from pneumonia infection through interferon gamma

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INTRINSIC CAPACITY OF MONOCYTES TO PRODUCE CYTOKINES EX VIVO IN PATIENTS WITH ACUTE LYMPHOBLASTIC LEUKAEMIA

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IN VIVO EFFECT OF rhGM-CSF AND rhG-CSF ON MONOCYTE HLA-DR EXPRESSION OF SEPTIC NEONATES

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Deactivation of the Innate Cellular Immune Response Following Endotoxic and Surgical Injury

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Peripheral blood phagocyte CD14 and CD11b expression on admission to hospital in relation to mortality among patients with community-acquired infection

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Anti-tumor necrosis factor α F(ab')2 antibody fragments protect in murine polymicrobial sepsis: Concentration and early intervention are fundamental to the outcome

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Differential immunostimulating effect of Granulocyte-macrophage colony-stimulating factor (GM-CSF), Granulocyte colony-stimulating factor (G-CSF) and Interferon γ (IFNγ) after severe trauma

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Serum-induced macrophage activation is related to the severity of septic shock

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Enhanced survival from CLP-induced sepsis following late administration of low doses of anti-IFNγ F(ab′)2 antibody fragments

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Granulocyte-colony stimulating factor in the prevention of postoperative infectious complications and sub-optimal recovery from operation in patients with colorectal cancer and increased preoperative risk (ASA 3 and 4)¶ Protocol for a controlled clinical trial developed by consensus of an…

inferred← citeshttps://doi.org/10.1007/s00101-003-0626-4openalex-snapshot

Bedeutung der angeborenen Immunantwort in der Sepsis

inferred← citeshttps://doi.org/10.1007/s00101-006-0983-xopenalex-snapshot

Einfluss des Geschlechts auf die stimulierbare Zytokinantwort bei Patienten mit schwerer Sepsis

inferred← citeshttps://doi.org/10.1007/s00101-014-2347-2openalex-snapshot

Einsatz von Biomarkern in der Sepsis

inferred← citeshttps://doi.org/10.1007/s001010050595openalex-snapshot

Anästhesie und perioperative Immunfunktion

inferred← citeshttps://doi.org/10.1007/s001010100149openalex-snapshot

Modulation of endotoxin-stimulated TNF-α gene expression by ketamine and propofol in cultured human whole blood

inferred← citeshttps://doi.org/10.1007/s00104-002-0559-5openalex-snapshot

Immunmodulation in der Sepsis

inferred← citeshttps://doi.org/10.1007/s001040050028openalex-snapshot

Immunparalyse von T-Lymphocyten und Monocyten in der postoperativen abdominellen Sepsis

inferred← citeshttps://doi.org/10.1007/s00109-007-0300-4openalex-snapshot

Molecular and cellular aspects of sepsis-induced immunosuppression

inferred← citeshttps://doi.org/10.1007/s001099900051openalex-snapshot

Mechanisms of brain-mediated systemic anti-inflammatory syndrome causing immunodepression

inferred← citeshttps://doi.org/10.1007/s001130050639openalex-snapshot

Mediatorenmodulation bei Sepsis und Multiorganversagen

inferred← citeshttps://doi.org/10.1007/s00134-002-1335-1openalex-snapshot

Low plasma granulocyte-macrophage colony stimulating factor is an indicator of poor prognosis in sepsis

inferred← citeshttps://doi.org/10.1007/s00134-002-1383-6openalex-snapshot

Future directions in the management of tertiary peritonitis

inferred← citeshttps://doi.org/10.1007/s00134-002-1623-9openalex-snapshot

Bactericidal activity response of blood neutrophils from critically ill patients to in vitro granulocyte colony-stimulating factor stimulation

inferred← citeshttps://doi.org/10.1007/s00134-003-1666-6openalex-snapshot

Reversal of immunoparalysis by recombinant human granulocyte-macrophage colony-stimulating factor in patients with severe sepsis

inferred← citeshttps://doi.org/10.1007/s00134-003-1686-2openalex-snapshot

Is low monocyte HLA-DR expression helpful to predict outcome in severe sepsis?

inferred← citeshttps://doi.org/10.1007/s00134-003-1900-2openalex-snapshot

ω-3 vs. ω-6 lipid emulsions exert differential influence on neutrophils in septic shock patients: impact on plasma fatty acids and lipid mediator generation

inferred← citeshttps://doi.org/10.1007/s00134-003-2049-8openalex-snapshot

Is there a place for granulocyte colony-stimulating factor in non-neutropenic critically ill patients?

inferred← citeshttps://doi.org/10.1007/s00134-003-2118-zopenalex-snapshot

Transient Bcl-2 gene down-expression in circulating mononuclear cells of severe sepsis patients who died despite appropriate intensive care

inferred← citeshttps://doi.org/10.1007/s00134-006-0204-8openalex-snapshot

Persisting low monocyte human leukocyte antigen-DR expression predicts mortality in septic shock

inferred← citeshttps://doi.org/10.1007/s00134-006-0205-7openalex-snapshot

Is the measurement of monocytes HLA-DR expression useful in patients with sepsis?

inferred← citeshttps://doi.org/10.1007/s00134-007-0968-5openalex-snapshot

The human response to infection is associated with distinct patterns of interleukin 23 and interleukin 27 expression

inferred← citeshttps://doi.org/10.1007/s00134-008-1086-8openalex-snapshot

Back to basics in septic shock

inferred← citeshttps://doi.org/10.1007/s00134-009-1472-xopenalex-snapshot

Predictors of bacteraemia and mortality in patients with acute liver failure

inferred← citeshttps://doi.org/10.1007/s00134-010-1962-xopenalex-snapshot

Low monocyte human leukocyte antigen-DR is independently associated with nosocomial infections after septic shock

inferred← citeshttps://doi.org/10.1007/s00134-010-1965-7openalex-snapshot

Measurement of monocytic HLA-DR (mHLA-DR) expression in patients with severe sepsis and septic shock: assessment of immune organ failure

inferred← citeshttps://doi.org/10.1007/s00134-010-2088-xopenalex-snapshot

Immunoparalysis and nosocomial infection in children with multiple organ dysfunction syndrome

inferred← citeshttps://doi.org/10.1007/s00134-013-3169-4openalex-snapshot

Mucosal associated invariant T (MAIT) cell: a novel cellular mechanism participating in post-aggressive immunodepression

inferred← citeshttps://doi.org/10.1007/s00134-018-5247-0openalex-snapshot

Cell-surface signatures of immune dysfunction risk-stratify critically ill patients: INFECT study

inferred← citeshttps://doi.org/10.1007/s00134-019-05923-4openalex-snapshot

Immunity check should be performed for all patients with septic shock? No

inferred← citeshttps://doi.org/10.1007/s00134-023-07065-0openalex-snapshot

Interferon gamma-1b for the prevention of hospital-acquired pneumonia in critically ill patients: a phase 2, placebo-controlled randomized clinical trial

inferred← citeshttps://doi.org/10.1007/s00134-026-08360-2openalex-snapshot

Surviving Sepsis Campaign International Guidelines for the Management of Sepsis and Septic Shock in Children 2026

inferred← citeshttps://doi.org/10.1007/s001340050554openalex-snapshot

Pro-inflammatory cytokine release and mediation of the acute phase protein response in fulminant hepatic failure

inferred← citeshttps://doi.org/10.1007/s001340050795openalex-snapshot

T helper cell subset ratios in patients with severe sepsis

inferred← citeshttps://doi.org/10.1007/s001340051126openalex-snapshot

Neutropenia: clinical implications and modulation

inferred← citeshttps://doi.org/10.1007/s001340051129openalex-snapshot

Immunomodulatory therapies in sepsis

inferred← citeshttps://doi.org/10.1007/s00251-009-0395-6openalex-snapshot

Mortality in adult intensive care patients with severe systemic inflammatory response syndromes is strongly associated with the hypo-immune TNF −238A polymorphism

inferred← citeshttps://doi.org/10.1007/s00268-004-7210-1openalex-snapshot

Dependence of Positive Effects of Granulocyte Colony‐stimulating Factor on the Antibiotic Regimen: Evaluation in Rats with Polymicrobial Peritonitis

inferred← citeshttps://doi.org/10.1007/s002689910112openalex-snapshot

Manipulations of the Metabolic Response for Management of Patients with Severe Surgical Illness: Review

inferred← citeshttps://doi.org/10.1007/s00277-003-0770-6openalex-snapshot

Sepsis in neutropenia

inferred← citeshttps://doi.org/10.1007/s00277-014-2185-yopenalex-snapshot

Human leukocyte antigen DR surface expression on CD14+ monocytes during adverse events after hematopoietic stem cell transplantation

inferred← citeshttps://doi.org/10.1007/s00277-014-2287-6openalex-snapshot

Patterns of monocyte subpopulations and their surface expression of HLA-DR during adverse events after hematopoietic stem cell transplantation

inferred← citeshttps://doi.org/10.1007/s00383-005-1574-7openalex-snapshot

TNF-α is a mediator of the anti-inflammatory response in a human neonatal model of the non-septic shock syndrome

inferred← citeshttps://doi.org/10.1007/s00384-004-0707-0openalex-snapshot

Impact of interleukin-12, oxidative burst, and iNOS on the survival of murine fecal peritonitis

inferred← citeshttps://doi.org/10.1007/s003840100338openalex-snapshot

Immunomodulatory changes in patients with colorectal cancer

inferred← citeshttps://doi.org/10.1007/s00390-002-0268-9openalex-snapshot

Die klinische Relevanz biochemischer Parameter für die Diagnose, Prognose und Therapie polytraumatisierter Patienten

inferred← citeshttps://doi.org/10.1007/s00390-007-0758-xopenalex-snapshot

Die extrakorporale Therapie septischer Patienten

inferred← citeshttps://doi.org/10.1007/s00390-011-0257-yopenalex-snapshot

Komplikationen bei immuninkompetenten Patienten

inferred← citeshttps://doi.org/10.1007/s00398-003-0403-3openalex-snapshot

Immunmonitoring bei Sepsis

inferred← citeshttps://doi.org/10.1007/s00423-004-0472-0openalex-snapshot

Surgical trauma: hyperinflammation versus immunosuppression?

inferred← citeshttps://doi.org/10.1007/s004310051121openalex-snapshot

In vitro immunoglobulin response of fetal B-cells is influenced by perinatal infections and antibiotic treatment: a study in preterm infants

inferred← citeshttps://doi.org/10.1007/s00595-010-4323-zopenalex-snapshot

Immunosuppression following surgical and traumatic injury

inferred← citeshttps://doi.org/10.1007/s10517-013-2183-4openalex-snapshot

Pathomorphosis of Experimental Infection in Mice, Infected by Streptococcus Pneumoniae, under the Effect of Immunotropic Drugs

inferred← citeshttps://doi.org/10.1007/s10753-009-9136-0openalex-snapshot

Fish Oil-Supplemented Parenteral Nutrition in Severe Acute Pancreatitis Patients and Effects on Immune Function and Infectious Risk: A Randomized Controlled Trial

inferred← citeshttps://doi.org/10.1007/s10753-013-9753-5openalex-snapshot

Combination Therapy with Thymosin Alpha1 and Dexamethasone Helps Mice Survive Sepsis

inferred← citeshttps://doi.org/10.1007/s10753-024-02148-6openalex-snapshot

IL-33 in Ischemic Stroke: Brain vs. Periphery

inferred← citeshttps://doi.org/10.1007/s10875-006-9023-5openalex-snapshot

Immunologic Effector Mechanisms of a Standardized Mistletoe Extract on the Function of Human Monocytes and Lymphocytes in vitro, ex vivo, and in vivo

inferred← citeshttps://doi.org/10.1007/s11011-024-01402-yopenalex-snapshot

Infection, inflammation and hepatic encephalopathy from a clinical perspective

inferred← citeshttps://doi.org/10.1007/s11897-014-0247-zopenalex-snapshot

Pathophysiology of Sepsis-Related Cardiac Dysfunction: Driven by Inflammation, Energy Mismanagement, or Both?

inferred← citeshttps://doi.org/10.1007/s11908-006-0045-1openalex-snapshot

Biomarkers of sepsis

inferred← citeshttps://doi.org/10.1007/s11908-013-0362-0openalex-snapshot

Noncanonical Nuclear Factor Kappa B (NF-κB) Signaling and Potential for Therapeutics in Sepsis

inferred← citeshttps://doi.org/10.1007/s12325-017-0622-8openalex-snapshot

Sepsis: A Review of Advances in Management

inferred← citeshttps://doi.org/10.1007/s13539-010-0010-6openalex-snapshot

Intensive care unit—acquired weakness (ICUAW) and muscle wasting in critically ill patients with severe sepsis and septic shock

inferred← citeshttps://doi.org/10.1007/s13546-012-0462-4openalex-snapshot

Immunodépression induite par le sepsis: réalité clinique et données expérimentales

inferred← citeshttps://doi.org/10.1007/s13546-015-1032-zopenalex-snapshot

L’immunodépression post-traumatique : de la physiopathologie au traitement

inferred← citeshttps://doi.org/10.1007/s15010-023-01983-3openalex-snapshot

Prospective flow cytometry analysis of leucocyte subsets in critically ill patients who develop sepsis: a pilot study

inferred← citeshttps://doi.org/10.1007/s40472-014-0022-9openalex-snapshot

Postoperative Monitoring: Biomarkers and Alloimmune Responses and Their Relevance to Vascularized Composite Allotransplantation

inferred← citeshttps://doi.org/10.1007/s43188-020-00051-4openalex-snapshot

Effect of low-dose corticosterone pretreatment on the production of inflammatory mediators in super-low-dose LPS-primed immune cells

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