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P2X7 receptor inhibition improves recovery after spinal cord injury

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/glia.10257openalex-snapshot

Modulation of intercellular calcium signaling in astrocytes by extracellular calcium and magnesium

inferredcites →https://doi.org/10.1006/exnr.1999.7041openalex-snapshot

Calcium Influx and Activation of Calpain I Mediate Acute Reactive Gliosis in Injured Spinal Cord

inferredcites →https://doi.org/10.1016/0014-4886(83)90307-2openalex-snapshot

Extracellular calcium activity in the injured spinal cord

inferredcites →https://doi.org/10.1016/j.nbd.2003.11.015openalex-snapshot

Degenerative and regenerative mechanisms governing spinal cord injury

inferredcites →https://doi.org/10.1016/j.tins.2003.08.008openalex-snapshot

New roles for astrocytes: Redefining the functional architecture of the brain

inferredcites →https://doi.org/10.1016/s0014-2999(02)01848-4openalex-snapshot

Extracellular ATP and P2X7 receptors in neurodegeneration

inferredcites →https://doi.org/10.1016/s0014-2999(99)00350-7openalex-snapshot

Pharmacological characterization of recombinant human and rat P2X receptor subtypes

inferredcites →https://doi.org/10.1016/s0021-9258(18)53082-9openalex-snapshot

Oxidized ATP. An irreversible inhibitor of the macrophage purinergic P2Z receptor.

inferredcites →https://doi.org/10.1016/s0028-3908(97)00123-8openalex-snapshot

Purines and their roles in apoptosis

inferredcites →https://doi.org/10.1016/s0028-3908(97)00140-8openalex-snapshot

Tissue distribution of the P2X7 receptor

inferredcites →https://doi.org/10.1016/s0166-2236(03)00237-6openalex-snapshot

New roles for astrocytes: Regulation of synaptic transmission

inferredcites →https://doi.org/10.1016/s0304-3959(01)00372-4openalex-snapshot

Cell damage excites nociceptors through release of cytosolic ATP

inferredcites →https://doi.org/10.1038/2210openalex-snapshot

Gap-junction-mediated propagation and amplification of cell injury

inferredcites →https://doi.org/10.1038/35058528openalex-snapshot

Glia: listening and talking to the synapse

inferredcites →https://doi.org/10.1038/7233openalex-snapshot

Neuronal P2X transmitter-gated cation channels change their ion selectivity in seconds

inferredcites →https://doi.org/10.1038/jcbfm.1993.22openalex-snapshot

Regional Changes in Interstitial K + and Ca 2+ Levels following Cortical Compression Contusion Trauma in Rats

inferredcites →https://doi.org/10.1038/jcbfm.1993.74openalex-snapshot

Characterization of Cortical Depolarizations Evoked in Focal Cerebral Ischemia

inferredcites →https://doi.org/10.1038/nbt944openalex-snapshot

Telomerase immortalization of neuronally restricted progenitor cells derived from the human fetal spinal cord

inferredcites →https://doi.org/10.1038/nm0802-785openalex-snapshot

Erythropoietin strikes a new cord

inferredcites →https://doi.org/10.1038/nm0901-1010openalex-snapshot

Glutamate release promotes growth of malignant gliomas

inferredcites →https://doi.org/10.1038/nrn916openalex-snapshot

Beyond the role of glutamate as a neurotransmitter

inferredcites →https://doi.org/10.1038/sj.bjp.0703368openalex-snapshot

Antagonist effects on human P2X7 receptor‐mediated cellular accumulation of YO‐PRO‐1

inferredcites →https://doi.org/10.1038/sj.cdd.4400341openalex-snapshot

Cytolytic P2X purinoceptors

inferredcites →https://doi.org/10.1046/j.1471-4159.2001.00272.xopenalex-snapshot

ATP stimulates calcium‐dependent glutamate release from cultured astrocytes

inferredcites →https://doi.org/10.1073/pnas.152588599openalex-snapshot

Intercellular calcium signaling mediated by point-source burst release of ATP

inferredcites →https://doi.org/10.1073/pnas.95.26.15735openalex-snapshot

Connexins regulate calcium signaling by controlling ATP release

inferredcites →https://doi.org/10.1074/jbc.m006781200openalex-snapshot

Altered Cytokine Production in Mice Lacking P2X7Receptors

inferredcites →https://doi.org/10.1074/jbc.m209478200openalex-snapshot

P2X7 Mediates Superoxide Production in Primary Microglia and Is Up-regulated in a Transgenic Mouse Model of Alzheimer's Disease

inferredcites →https://doi.org/10.1080/01616412.1996.11740463openalex-snapshot

Pretreatment with NMDA receptor antagonist MK801 improves neurophysiological outcome after an acute spinal cord injury

inferredcites →https://doi.org/10.1089/neu.1995.12.1openalex-snapshot

A Sensitive and Reliable Locomotor Rating Scale for Open Field Testing in Rats

inferredcites →https://doi.org/10.1089/neu.1996.13.537openalex-snapshot

Changes of Extracellular Levels of Amino Acids after Graded Compression Trauma to the Spinal Cord: An Experimental Study in the Rat Using Microdialysis

inferredcites →https://doi.org/10.1093/jnen/60.5.422openalex-snapshot

Apoptotic and Anti-Apoptotic Mechanisms Following Spinal Cord Injury

inferredcites →https://doi.org/10.1097/00004647-200303000-00013openalex-snapshot

Role of P2X 7 Receptors in Ischemic and Excitotoxic Brain Injury In Vivo

inferredcites →https://doi.org/10.1111/j.1469-7793.1999.377ac.xopenalex-snapshot

Confocal calcium imaging reveals an ionotropic P2 nucleotide receptor in the paranodal membrane of rat Schwann cells

inferredcites →https://doi.org/10.1126/science.298.5593.556openalex-snapshot

New Insights into Neuron-Glia Communication

inferredcites →https://doi.org/10.1152/physrev.00015.2002openalex-snapshot

Molecular Physiology of P2X Receptors

inferredcites →https://doi.org/10.14670/hh-17.1137openalex-snapshot

Molecular mechanisms in the pathogenesis of traumatic brain injury.

inferredcites →https://doi.org/10.1523/jneurosci.17-03-01055.1997openalex-snapshot

Role of NMDA and Non-NMDA Ionotropic Glutamate Receptors in Traumatic Spinal Cord Axonal Injury

inferredcites →https://doi.org/10.1523/jneurosci.17-19-07359.1997openalex-snapshot

Impact of Cytoplasmic Calcium Buffering on the Spatial and Temporal Characteristics of Intercellular Calcium Signals in Astrocytes

inferredcites →https://doi.org/10.1523/jneurosci.19-02-00520.1999openalex-snapshot

ATP Released from Astrocytes Mediates Glial Calcium Waves

inferredcites →https://doi.org/10.1523/jneurosci.20-04-01435.2000openalex-snapshot

Intercellular Communication in Spinal Cord Astrocytes: Fine Tuning between Gap Junctions and P2 Nucleotide Receptors in Calcium Wave Propagation

inferredcites →https://doi.org/10.1523/jneurosci.20-08-02800.2000openalex-snapshot

P2Y1Purinoceptor-Mediated Ca2+Signaling and Ca2+Wave Propagation in Dorsal Spinal Cord Astrocytes

inferredcites →https://doi.org/10.1523/jneurosci.21-18-07143.2001openalex-snapshot

Neuronal P2X7Receptors Are Targeted to Presynaptic Terminals in the Central and Peripheral Nervous Systems

inferredcites →https://doi.org/10.1523/jneurosci.22-14-05938.2002openalex-snapshot

Activation of Presynaptic P2X7-Like Receptors Depresses Mossy Fiber–CA3 Synaptic Transmission through p38 Mitogen-Activated Protein Kinase

inferredcites →https://doi.org/10.1523/jneurosci.23-02-00430.2003openalex-snapshot

Connexin Mediates Gap Junction-Independent Resistance to Cellular Injury

inferredcites →https://doi.org/10.1523/jneurosci.23-04-01320.2003openalex-snapshot

P2X 7 Receptor-Mediated Release of Excitatory Amino Acids from Astrocytes

inferredcites →https://doi.org/10.1523/jneurosci.23-06-02348.2003openalex-snapshot

Activation of Extracellular Signal-Regulated Kinase by Stretch-Induced Injury in Astrocytes Involves Extracellular ATP and P2 Purinergic Receptors

inferredcites →https://doi.org/10.1523/jneurosci.3792-03.2004openalex-snapshot

Production and Release of Neuroprotective Tumor Necrosis Factor by P2X7Receptor-Activated Microglia

inferredcites →https://doi.org/10.1523/jneurosci.5429-03.2004openalex-snapshot

Contribution of Calcium Ions to P2X Channel Responses

inferredcites →https://doi.org/10.3171/jns.1980.52.6.0801openalex-snapshot

Comparison of hydrogen clearance and 14C-antipyrine autoradiography in the measurement of spinal cord blood flow after severe impact injury

inferredcites →https://doi.org/10.3171/jns.1998.89.6.0911openalex-snapshot

Apoptosis after traumatic human spinal cord injury

inferredcites →https://doi.org/10.4049/jimmunol.168.12.6436openalex-snapshot

Absence of the P2X7 Receptor Alters Leukocyte Function and Attenuates an Inflammatory Response

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.4054690openalex-extracted

Brain Damage-Linked ATP Promotes P2X7 Mediated Pineal Nacetylserotonin Release

inferred← citeshttps://doi.org/10.1001/jamaneurol.2014.3558openalex-snapshot

Inflammation and Neuroprotection in Traumatic Brain Injury

inferred← citeshttps://doi.org/10.1001/jamasurg.2014.2029openalex-snapshot

Brilliant Blue FCF as an Alternative Dye for Saphenous Vein Graft Marking

inferred← citeshttps://doi.org/10.1002/adma.202500623openalex-snapshot

High‐Efficiency Ocular Delivery of Brain‐Derived Neurotrophic Factor and Oligomycin for Neuroprotection in Glaucoma

inferred← citeshttps://doi.org/10.1002/cne.21964openalex-snapshot

Extracellular ATP induces retinal photoreceptor apoptosis through activation of purinoceptors in rodents

inferred← citeshttps://doi.org/10.1002/ddr.20101openalex-snapshot

Purinergic control of neuropathic pain

inferred← citeshttps://doi.org/10.1002/glia.20205openalex-snapshot

Role of glial cells in cerebral ischemia

inferred← citeshttps://doi.org/10.1002/glia.20379openalex-snapshot

P2X7 receptors on microglial cells mediate injury to cortical neurons in vitro

inferred← citeshttps://doi.org/10.1002/glia.20397openalex-snapshot

P2X7 receptors: Properties and relevance to CNS function

inferred← citeshttps://doi.org/10.1002/glia.20509openalex-snapshot

Purines induce directed migration and rapid homing of microglia to injured pyramidal neurons in developing hippocampus

inferred← citeshttps://doi.org/10.1002/glia.20749openalex-snapshot

P2Y1receptor signaling enhances neuroprotection by astrocytes against oxidative stress via IL‐6 release in hippocampal cultures

inferred← citeshttps://doi.org/10.1002/glia.20758openalex-snapshot

Downregulation of P2X7receptor expression in rat oligodendrocyte precursor cells after hypoxia ischemia

inferred← citeshttps://doi.org/10.1002/glia.20763openalex-snapshot

Endogenous signals initiating inflammation in the injured nervous system

inferred← citeshttps://doi.org/10.1002/glia.20813openalex-snapshot

Microglial cell migration stimulated by ATP and C5a involve distinct molecular mechanisms: Quantification of migration by a novel near‐infrared method

inferred← citeshttps://doi.org/10.1002/glia.20958openalex-snapshot

P2X7 receptors mediate ischemic damage to oligodendrocytes

inferred← citeshttps://doi.org/10.1002/glia.21042openalex-snapshot

Cathepsin S release from primary cultured microglia is regulated by the P2X7 receptor

inferred← citeshttps://doi.org/10.1002/glia.21138openalex-snapshot

Signaling pathways of ATP‐induced PGE2 release in spinal cord astrocytes are EGFR transactivation‐dependent

inferred← citeshttps://doi.org/10.1002/glia.21237openalex-snapshot

The GPR17 receptor in NG2 expressing cells: Focus on in vivo cell maturation and participation in acute trauma and chronic damage

inferred← citeshttps://doi.org/10.1002/glia.22384openalex-snapshot

Astrocytic CX43 hemichannels and gap junctions play a crucial role in development of chronic neuropathic pain following spinal cord injury

inferred← citeshttps://doi.org/10.1002/glia.22491openalex-snapshot

Nerve injury induces glial cell line‐derived neurotrophic factor (gdnf) expression in schwann cells through purinergic signaling and the pkc‐pkd pathway

inferred← citeshttps://doi.org/10.1002/glia.22506openalex-snapshot

UDP‐glucose enhances outward K+ currents necessary for cell differentiation and stimulates cell migration by activating the GPR17 receptor in oligodendrocyte precursors

inferred← citeshttps://doi.org/10.1002/glia.22534openalex-snapshot

Critical role for PAR1 in kallikrein 6‐mediated oligodendrogliopathy

inferred← citeshttps://doi.org/10.1002/glia.22559openalex-snapshot

An increase in voltage‐gated sodium channel current elicits microglial activation followed inflammatory responses in vitro and in vivo after spinal cord injury

inferred← citeshttps://doi.org/10.1002/glia.22588openalex-snapshot

Rapid manifestation of reactive astrogliosis in acute hippocampal brain slices

inferred← citeshttps://doi.org/10.1002/glia.22833openalex-snapshot

Different danger signals differently impact on microglial proliferation through alterations of ATP release and extracellular metabolism

inferred← citeshttps://doi.org/10.1002/glia.23059openalex-snapshot

ATP-induced IL-1β secretion is selectively impaired in microglia as compared to hematopoietic macrophages

inferred← citeshttps://doi.org/10.1002/glia.23089openalex-snapshot

Novel insights into role of miR-320a-VDAC1 axis in astrocyte-mediated neuronal damage in neuroAIDS

inferred← citeshttps://doi.org/10.1002/glia.24250openalex-snapshot

Single channel properties of pannexin‐1 and connexin‐43 hemichannels and P2X7 receptors in astrocytes cultured from rodent spinal cords

inferred← citeshttps://doi.org/10.1002/hipo.20269openalex-snapshot

Extracellular adenosine triphosphate induces glutamate transporter‐1 expression in hippocampus

inferred← citeshttps://doi.org/10.1002/hipo.20850openalex-snapshot

P2X7 receptor differentially modulates astroglial apoptosis and clasmatodendrosis in the rat brain following status epilepticus

inferred← citeshttps://doi.org/10.1002/jcb.22478openalex-snapshot

Characterization of ATP‐induced cell death in the GL261 mouse glioma

inferred← citeshttps://doi.org/10.1002/jcb.24010openalex-snapshot

Ca2+ store depletion and endoplasmic reticulum stress are involved in P2X7 receptor‐mediated neurotoxicity in differentiated NG108‐15 cells

inferred← citeshttps://doi.org/10.1002/jcp.26287openalex-snapshot

Inflammasome: Its role in traumatic brain and spinal cord injury

inferred← citeshttps://doi.org/10.1002/jnr.22784openalex-snapshot

Early in vivo changes in calcium ions, oxidative stress markers, and ion channel immunoreactivity following partial injury to the optic nerve

inferred← citeshttps://doi.org/10.1002/jnr.23200openalex-snapshot

Valproic acid attenuates microgliosis in injured spinal cord and purinergic P2X4 receptor expression in activated microglia

inferred← citeshttps://doi.org/10.1002/jnr.23417openalex-snapshot

Purinergic signaling mediated by P2X 7 receptors controls myelination in sciatic nerves

inferred← citeshttps://doi.org/10.1002/jnr.23487openalex-snapshot

Insight into astrocyte activation after optic nerve injury

inferred← citeshttps://doi.org/10.1002/jnr.23950openalex-snapshot

Extracellular ATP induces graded reactive response of astrocytes and strengthens their antioxidative defense in vitro

inferred← citeshttps://doi.org/10.1002/med.21952openalex-snapshot

Leveraging the ATP‐P2X7 receptor signalling axis to alleviate traumatic CNS damage and related complications

inferred← citeshttps://doi.org/10.1002/stem.2894openalex-snapshot

P2X7 Receptors Regulate Phagocytosis and Proliferation in Adult Hippocampal and SVZ Neural Progenitor Cells: Implications for Inflammation in Neurogenesis

inferred← citeshttps://doi.org/10.1007/5584_2017_59openalex-snapshot

The P2X7 Receptor

inferred← citeshttps://doi.org/10.1007/978-1-4419-9530-8_3openalex-snapshot

Experimental Platforms for Assessing White Matter Pathophysiology in Stroke

inferred← citeshttps://doi.org/10.1007/978-1-4614-9123-1_10openalex-snapshot

Experimental Global Ischemia and White Matter Injury

inferred← citeshttps://doi.org/10.1007/978-3-030-24285-5_8openalex-snapshot

Molecular Chaperones and Protein Quality Control System in the Canine Model of Brain Aging and Neurodegenerative Diseases

inferred← citeshttps://doi.org/10.1007/978-3-319-08894-5_11openalex-snapshot

Pathological Potential of Astroglial Purinergic Receptors

inferred← citeshttps://doi.org/10.1007/978-3-319-62817-2_13openalex-snapshot

Progenitors in the Ependyma of the Spinal Cord: A Potential Resource for Self-Repair After Injury

inferred← citeshttps://doi.org/10.1007/978-3-319-69194-7_5openalex-snapshot

Spinal Cord Stem Cells In Their Microenvironment: The Ependyma as a Stem Cell Niche

inferred← citeshttps://doi.org/10.1007/978-3-642-28863-0_8openalex-snapshot

Purinergic Signalling in the Central Nervous System

inferred← citeshttps://doi.org/10.1007/978-4-431-54880-5_11openalex-snapshot

Photoreceptor Degeneration: Molecular Mechanisms of Photoreceptor Degeneration

inferred← citeshttps://doi.org/10.1007/978-981-99-8921-8_7openalex-snapshot

Astrocytes and Microglia in Chronic Postsurgical Pain

inferred← citeshttps://doi.org/10.1007/s00044-026-03583-wopenalex-snapshot

From danger to resolution: targeting purinergic signaling in CNS diseases

inferred← citeshttps://doi.org/10.1007/s00109-005-0663-3openalex-snapshot

Molecular targets in spinal cord injury

inferred← citeshttps://doi.org/10.1007/s00210-014-1005-1openalex-snapshot

Functional P2X7 receptors at cultured hippocampal astrocytes but not neurons

inferred← citeshttps://doi.org/10.1007/s00424-006-0070-9openalex-snapshot

Pharmacology of P2X channels

inferred← citeshttps://doi.org/10.1007/s00424-006-0071-8openalex-snapshot

P2 receptors and neuronal injury

inferred← citeshttps://doi.org/10.1007/s00424-011-0980-zopenalex-snapshot

Expression and functional characterization of P2X receptors in mouse alveolar macrophages

inferred← citeshttps://doi.org/10.1007/s10238-011-0139-4openalex-snapshot

Effects of propofol on P2X7 receptors and the secretion of tumor necrosis factor-α in cultured astrocytes

inferred← citeshttps://doi.org/10.1007/s10384-024-01087-xopenalex-snapshot

Intraocular kinetics of pathological ATP after photoreceptor damage in rhegmatogenous retinal detachment

inferred← citeshttps://doi.org/10.1007/s10571-014-0092-3openalex-snapshot

ATP Signaling in Brain: Release, Excitotoxicity and Potential Therapeutic Targets

inferred← citeshttps://doi.org/10.1007/s10620-019-05496-8openalex-snapshot

Blockage of the P2X7 Receptor Attenuates Harmful Changes Produced by Ischemia and Reperfusion in the Myenteric Plexus

inferred← citeshttps://doi.org/10.1007/s11010-009-0288-xopenalex-snapshot

Inhibition of neuronal cell death after retinoic acid-induced down-regulation of P2X7 nucleotide receptor expression

inferred← citeshttps://doi.org/10.1007/s11068-007-9011-6openalex-snapshot

Cross talk between vestibular neurons and Schwann cells mediates BDNF release and neuronal regeneration

inferred← citeshttps://doi.org/10.1007/s11302-005-6312-zopenalex-snapshot

Purinergic mechanism in the immune system: A signal of danger for dendritic cells

inferred← citeshttps://doi.org/10.1007/s11302-005-7145-5openalex-snapshot

P2X7 nucleotide receptors mediate caspase-8/9/3-dependent apoptosis in rat primary cortical neurons

inferred← citeshttps://doi.org/10.1007/s11302-006-9018-yopenalex-snapshot

Kinetics of ATP release following compression injury of a peripheral nerve trunk

inferred← citeshttps://doi.org/10.1007/s11302-006-9024-0openalex-snapshot

Shaping immune responses through the activation of dendritic cells–P2 receptors

inferred← citeshttps://doi.org/10.1007/s11302-006-9041-zopenalex-snapshot

Shaping immune responses through the activation of dendritic cells’ P2 receptors

inferred← citeshttps://doi.org/10.1007/s11302-006-9043-xopenalex-snapshot

Purinergic modulation of microglial cell activation

inferred← citeshttps://doi.org/10.1007/s11302-007-9071-1openalex-snapshot

Modification of neuropathic pain sensation through microglial ATP receptors

inferred← citeshttps://doi.org/10.1007/s11302-007-9074-yopenalex-snapshot

New insights into purinergic receptor signaling in neuronal differentiation, neuroprotection, and brain disorders

inferred← citeshttps://doi.org/10.1007/s11302-007-9080-0openalex-snapshot

P2 receptor-mediated modulation of neurotransmitter release—an update

inferred← citeshttps://doi.org/10.1007/s11302-008-9115-1openalex-snapshot

ATP signalling in epilepsy

inferred← citeshttps://doi.org/10.1007/s11302-009-9138-2openalex-snapshot

Physiological and pathological functions of P2X7 receptor in the spinal cord

inferred← citeshttps://doi.org/10.1007/s11302-012-9310-yopenalex-snapshot

Purinergic trophic signalling in glial cells: functional effects and modulation of cell proliferation, differentiation, and death

inferred← citeshttps://doi.org/10.1007/s11302-013-9379-yopenalex-snapshot

Block of P2X7 receptors could partly reverse the delayed neuronal death in area CA1 of the hippocampus after transient global cerebral ischemia

inferred← citeshttps://doi.org/10.1007/s11302-015-9490-3openalex-snapshot

Saffron reduces ATP-induced retinal cytotoxicity by targeting P2X7 receptors

inferred← citeshttps://doi.org/10.1007/s11302-016-9507-6openalex-snapshot

Purinergic signalling in a latent stem cell niche of the rat spinal cord

inferred← citeshttps://doi.org/10.1007/s11302-016-9513-8openalex-snapshot

The effects of NONRATT021972 lncRNA siRNA on PC12 neuronal injury mediated by P2X7 receptor after exposure to oxygen-glucose deprivation

inferred← citeshttps://doi.org/10.1007/s11302-016-9541-4openalex-snapshot

Diadenosine tetraphosphate (Ap4A) inhibits ATP-induced excitotoxicity: a neuroprotective strategy for traumatic spinal cord injury treatment

inferred← citeshttps://doi.org/10.1007/s11302-017-9579-yopenalex-snapshot

Inhibition of P2X7 receptors improves outcomes after traumatic brain injury in rats

inferred← citeshttps://doi.org/10.1007/s11302-018-9633-4openalex-snapshot

Purinergic implication in amyotrophic lateral sclerosis—from pathological mechanisms to therapeutic perspectives

inferred← citeshttps://doi.org/10.1007/s11302-021-09822-6openalex-snapshot

Mechanisms of ATP release in pain: role of pannexin and connexin channels

inferred← citeshttps://doi.org/10.1007/s11302-022-09840-yopenalex-snapshot

MicroRNA: Crucial modulator in purinergic signalling involved diseases

inferred← citeshttps://doi.org/10.1007/s11302-025-10122-6openalex-snapshot

Modulation of immune responses by opioids through toll-like and P2X receptor signaling in COVID-19

inferred← citeshttps://doi.org/10.1007/s11884-010-0063-6openalex-snapshot

Role of Purinergic Signaling in Voiding Dysfunction

inferred← citeshttps://doi.org/10.1007/s12026-011-8203-4openalex-snapshot

Transcriptional control mechanisms associated with the nucleotide receptor P2X7, a critical regulator of immunologic, osteogenic, and neurologic functions

inferred← citeshttps://doi.org/10.1007/s12031-011-9567-6openalex-snapshot

Blockade of P2 Nucleotide Receptors After Spinal Cord Injury Reduced the Gliotic Response and Spared Tissue

inferred← citeshttps://doi.org/10.1007/s12035-008-8028-xopenalex-snapshot

P2X7 Receptors in Oligodendrocytes: A Novel Target for Neuroprotection

inferred← citeshttps://doi.org/10.1007/s12035-010-8120-xopenalex-snapshot

Roles of P2X7 Receptor in Glial and Neuroblastoma Cells: The Therapeutic Potential of P2X7 Receptor Antagonists

inferred← citeshttps://doi.org/10.1007/s12035-014-8943-yopenalex-snapshot

Purinergic Modulation of Spinal Neuroglial Maladaptive Plasticity Following Peripheral Nerve Injury

inferred← citeshttps://doi.org/10.1007/s12035-021-02410-0openalex-snapshot

BDNF Participates in Chronic Constriction Injury-Induced Neuropathic Pain via Transcriptionally Activating P2X7 in Primary Sensory Neurons

inferred← citeshttps://doi.org/10.1007/s12264-013-1338-7openalex-snapshot

P2X7 receptors in cerebral ischemia

inferred← citeshttps://doi.org/10.1007/s12975-013-0265-2openalex-snapshot

P2X7 Receptor Inhibition Increases CNTF in the Subventricular Zone, But Not Neurogenesis or Neuroprotection After Stroke in Adult Mice

inferred← citeshttps://doi.org/10.1007/s13311-011-0033-5openalex-snapshot

Oligodendrocyte Fate after Spinal Cord Injury

inferred← citeshttps://doi.org/10.1007/s13311-018-0630-7openalex-snapshot

Glial Cells Shape Pathology and Repair After Spinal Cord Injury

inferred← citeshttps://doi.org/10.1007/s13311-022-01269-wopenalex-snapshot

P2R Inhibitors Prevent Antibody-Mediated Complement Activation in an Animal Model of Neuromyelitis Optica

inferred← citeshttps://doi.org/10.1016/b978-0-08-102807-0.00010-7openalex-snapshot

Functional properties of progenitor-like cells in the spinal cord

inferred← citeshttps://doi.org/10.1016/b978-0-12-385526-8.00015-1openalex-snapshot

Role of Purinergic Receptors in CNS Function and Neuroprotection

inferred← citeshttps://doi.org/10.1016/b978-0-443-30250-3.00009-6openalex-snapshot

The contribution of extracellular ATP to retinal function and potentiating retinal degenerations

inferred← citeshttps://doi.org/10.1016/b978-0-443-30250-3.00031-xopenalex-snapshot

Extracellular ATP in inflammatory disorders

inferred← citeshttps://doi.org/10.1016/b978-0-443-40471-9.00009-4openalex-snapshot

Stem cells and pyroptosis in spinal injury

inferred← citeshttps://doi.org/10.1016/b978-008045046-9.01724-1openalex-snapshot

Calcium Waves: Purinergic Regulation

inferred← citeshttps://doi.org/10.1016/b978-012369371-6/50023-xopenalex-snapshot

Regenerative Medicine of Neural Tissues

inferred← citeshttps://doi.org/10.1016/bs.apcsb.2015.11.004openalex-snapshot

P2X7 Receptor as a Therapeutic Target

inferred← citeshttps://doi.org/10.1016/bs.pmbts.2014.11.014openalex-snapshot

Role of Extracellular Damage-Associated Molecular Pattern Molecules (DAMPs) as Mediators of Persistent Pain

inferred← citeshttps://doi.org/10.1016/j.ajpath.2011.08.035openalex-snapshot

Critical Involvement of Extracellular ATP Acting on P2RX7 Purinergic Receptors in Photoreceptor Cell Death

inferred← citeshttps://doi.org/10.1016/j.arr.2015.10.001openalex-snapshot

Emerging role of P2X7 receptors in CNS health and disease

inferred← citeshttps://doi.org/10.1016/j.autneu.2014.03.006openalex-snapshot

The role of P2X7 receptor in PC12 cells after exposure to oxygen–glucose deprivation

inferred← citeshttps://doi.org/10.1016/j.bbadis.2017.05.020openalex-snapshot

White matter damage after traumatic brain injury: A role for damage associated molecular patterns

inferred← citeshttps://doi.org/10.1016/j.bbamem.2012.01.002openalex-snapshot

The participation of plasma membrane hemichannels to purinergic signaling

inferred← citeshttps://doi.org/10.1016/j.bbamem.2014.10.029openalex-snapshot

Understanding the roles of the P2X7 receptor in solid tumour progression and therapeutic perspectives

inferred← citeshttps://doi.org/10.1016/j.bbamem.2017.03.025openalex-snapshot

Interactions of Pannexin1 channels with purinergic and NMDA receptor channels

inferred← citeshttps://doi.org/10.1016/j.bbi.2009.11.007openalex-snapshot

Astrocytes initiate inflammation in the injured mouse spinal cord by promoting the entry of neutrophils and inflammatory monocytes in an IL-1 receptor/MyD88-dependent fashion

inferred← citeshttps://doi.org/10.1016/j.bbi.2015.06.020openalex-snapshot

Extracellular ATP enhances radiation-induced brain injury through microglial activation and paracrine signaling via P2X7 receptor

inferred← citeshttps://doi.org/10.1016/j.bbi.2024.07.047openalex-snapshot

Constitutive DAMPs in CNS injury: From preclinical insights to clinical perspectives

inferred← citeshttps://doi.org/10.1016/j.bbi.2026.106279openalex-snapshot

Spatiotemporal PET imaging of P2X7R-driven neuroinflammation using [18F]GSK1482160 after experimental acute spinal cord injury in mice

inferred← citeshttps://doi.org/10.1016/j.bbr.2011.09.015openalex-snapshot

Spinal P2X7 receptor mediates microglia activation-induced neuropathic pain in the sciatic nerve injury rat model

inferred← citeshttps://doi.org/10.1016/j.bbrc.2007.08.095openalex-snapshot

P2X7 receptors mediate NADH transport across the plasma membranes of astrocytes

inferred← citeshttps://doi.org/10.1016/j.biomaterials.2010.01.084openalex-snapshot

Template synthesized poly(ɛ-caprolactone) nanowire surfaces for neural tissue engineering

inferred← citeshttps://doi.org/10.1016/j.biomed.2011.10.003openalex-snapshot

P2X7 receptor as a double-edged sword: Neurotrophic and neurotoxic effects

inferred← citeshttps://doi.org/10.1016/j.biosystems.2008.11.005openalex-snapshot

Oxygen-glucose deprivation-induced enhancement of extracellular ATP-P2Y purinoceptors signaling for the propagation of astrocytic calcium waves

inferred← citeshttps://doi.org/10.1016/j.bmc.2024.118054openalex-snapshot

Synthesis and in vitro evaluation of novel compounds and discovery of a promising iodine-125 radioligand for purinergic P2X7 receptor (P2X7R)

inferred← citeshttps://doi.org/10.1016/j.bmcl.2007.04.075openalex-snapshot

Novel and potent 3-(2,3-dichlorophenyl)-4-(benzyl)-4H-1,2,4-triazole P2X7 antagonists

inferred← citeshttps://doi.org/10.1016/j.bmcl.2009.09.053openalex-snapshot

Synthesis and structure–activity relationships of pyrazolodiazepine derivatives as human P2X7 receptor antagonists

inferred← citeshttps://doi.org/10.1016/j.bmcl.2015.08.004openalex-snapshot

Nanoparticle-encapsulated P2X7 receptor antagonist in a pH-sensitive polymer as a potential local drug delivery system to acidic inflammatory environments

inferred← citeshttps://doi.org/10.1016/j.brainres.2005.06.022openalex-snapshot

Functional expression of P2X7 receptors in non-neuronal cells of rat dorsal root ganglia

inferred← citeshttps://doi.org/10.1016/j.brainres.2007.11.064openalex-snapshot

Cellular localization of P2X7 receptor mRNA in the rat brain

inferred← citeshttps://doi.org/10.1016/j.brainres.2010.04.053openalex-snapshot

Excitation of rat spinal ventral horn neurons by purinergic P2X and P2Y receptor activation

inferred← citeshttps://doi.org/10.1016/j.brainres.2012.08.042openalex-snapshot

Connexin and pannexin hemichannels in inflammatory responses of glia and neurons

inferred← citeshttps://doi.org/10.1016/j.brainres.2017.05.025openalex-snapshot

Blockade of ATP P2X7 receptor enhances ischiatic nerve regeneration in mice following a crush injury

inferred← citeshttps://doi.org/10.1016/j.ceca.2011.08.002openalex-snapshot

Gain-of-function of P2X7 receptor gene variants in multiple sclerosis

inferred← citeshttps://doi.org/10.1016/j.cellsig.2009.01.036openalex-snapshot

Functional decreases in P2X7 receptors are associated with retinoic acid-induced neuronal differentiation of Neuro-2a neuroblastoma cells

inferred← citeshttps://doi.org/10.1016/j.drudis.2019.03.029openalex-snapshot

Targeting P2X7 receptors as a means for treating retinal disease

inferred← citeshttps://doi.org/10.1016/j.ejmech.2018.03.023openalex-snapshot

Synthesis and structure-activity relationships of quinolinone and quinoline-based P2X7 receptor antagonists and their anti-sphere formation activities in glioblastoma cells

inferred← citeshttps://doi.org/10.1016/j.ejpain.2008.08.001openalex-snapshot

Effects of Etanercept and Minocycline in a rat model of spinal cord injury

inferred← citeshttps://doi.org/10.1016/j.ejphar.2006.08.039openalex-snapshot

Oxidized ATP decreases β-actin expression and intracellular superoxide concentrations in RBA-2 type-2 astrocytes independently of P2X7 receptor

inferred← citeshttps://doi.org/10.1016/j.ejphar.2014.10.036openalex-snapshot

Subcellular distribution and early signalling events of P2X7 receptors from mouse cerebellar granule neurons

inferred← citeshttps://doi.org/10.1016/j.exer.2021.108569openalex-snapshot

Photoreceptor ablation following ATP induced injury triggers Müller glia driven regeneration in zebrafish

inferred← citeshttps://doi.org/10.1016/j.expneurol.2004.11.001openalex-snapshot

Immune and glial cell factors as pain mediators and modulators

inferred← citeshttps://doi.org/10.1016/j.expneurol.2008.11.026openalex-snapshot

Secondary degeneration of the optic nerve following partial transection: The benefits of lomerizine

inferred← citeshttps://doi.org/10.1016/j.expneurol.2011.03.001openalex-snapshot

A meta-analysis of microarray-based gene expression studies of olfactory bulb-derived olfactory ensheathing cells

inferred← citeshttps://doi.org/10.1016/j.expneurol.2011.06.008openalex-snapshot

A reassessment of P2X7 receptor inhibition as a neuroprotective strategy in rat models of contusion injury

inferred← citeshttps://doi.org/10.1016/j.expneurol.2011.06.017openalex-snapshot

Replication and reproducibility in spinal cord injury research

inferred← citeshttps://doi.org/10.1016/j.expneurol.2014.05.007openalex-snapshot

Understanding the neural repair-promoting properties of olfactory ensheathing cells

inferred← citeshttps://doi.org/10.1016/j.freeradbiomed.2006.03.004openalex-snapshot

Purinergic signaling and kinase activation for survival in pulmonary oxidative stress and disease

inferred← citeshttps://doi.org/10.1016/j.ijdevneu.2005.11.016openalex-snapshot

Changes in purinergic signaling after cerebral injury – involvement of glutamatergic mechanisms?

inferred← citeshttps://doi.org/10.1016/j.ijdevneu.2010.07.001openalex-snapshot

P2Y2 receptor expression is altered in rats after spinal cord injury

inferred← citeshttps://doi.org/10.1016/j.isci.2026.116636openalex-snapshot

Spinal cord injury induces mitochondrial dysfunction and metabolic reprogramming in non-regenerative Xenopus laevis

inferred← citeshttps://doi.org/10.1016/j.it.2015.08.002openalex-snapshot

Immune Surveillance of the CNS following Infection and Injury

inferred← citeshttps://doi.org/10.1016/j.jare.2020.08.004openalex-snapshot

Role of pyroptosis in spinal cord injury and its therapeutic implications

inferred← citeshttps://doi.org/10.1016/j.jneuroim.2006.07.008openalex-snapshot

Attenuated pseudorabies virus-evoked rapid innate immune response in the rat brain

inferred← citeshttps://doi.org/10.1016/j.jneuroim.2008.03.014openalex-snapshot

Interleukin-1β affects calcium signaling and in vitro cell migration of astrocyte progenitors

inferred← citeshttps://doi.org/10.1016/j.nbd.2006.08.018openalex-snapshot

Ivermectin inhibits AMPA receptor-mediated excitotoxicity in cultured motor neurons and extends the life span of a transgenic mouse model of amyotrophic lateral sclerosis

inferred← citeshttps://doi.org/10.1016/j.nbd.2010.02.013openalex-snapshot

NPY mediates ATP-induced neuroproliferation in adult mouse olfactory epithelium

inferred← citeshttps://doi.org/10.1016/j.nbd.2011.12.014openalex-snapshot

P2X7 receptor blockade prevents ATP excitotoxicity in neurons and reduces brain damage after ischemia

inferred← citeshttps://doi.org/10.1016/j.nbd.2013.06.011openalex-snapshot

P2X7R/cryopyrin inflammasome axis inhibition reduces neuroinflammation after SAH

inferred← citeshttps://doi.org/10.1016/j.nbd.2015.02.028openalex-snapshot

Targeting P2X7 receptor for the treatment of central post-stroke pain in a rodent model

inferred← citeshttps://doi.org/10.1016/j.nbd.2015.06.002openalex-snapshot

MMP-3 secreted from endothelial cells of blood vessels after spinal cord injury activates microglia, leading to oligodendrocyte cell death

inferred← citeshttps://doi.org/10.1016/j.nec.2006.10.009openalex-snapshot

Glial Progenitor–Based Repair of Demyelinating Neurological Diseases

inferred← citeshttps://doi.org/10.1016/j.neubiorev.2021.05.009openalex-snapshot

The effects of anaesthetics and sedatives on brain inflammation

inferred← citeshttps://doi.org/10.1016/j.neuint.2005.04.022openalex-snapshot

P2X7 receptor-mRNA and -protein in the mouse retina; changes during retinal degeneration in BALBCrds mice

inferred← citeshttps://doi.org/10.1016/j.neuint.2006.09.002openalex-snapshot

Receptor activated bladder and spinal ATP release in neurally intact and chronic spinal cord injured rats

inferred← citeshttps://doi.org/10.1016/j.neuint.2010.08.021openalex-snapshot

Temporal expression of P2X7 purinergic receptor during the course of experimental autoimmune encephalomyelitis

inferred← citeshttps://doi.org/10.1016/j.neuint.2016.12.006openalex-snapshot

The protective effect of resveratrol in the transmission of neuropathic pain mediated by the P2X7 receptor in the dorsal root ganglia

inferred← citeshttps://doi.org/10.1016/j.neuint.2021.105116openalex-snapshot

Potential therapeutic agents for ischemic white matter damage

inferred← citeshttps://doi.org/10.1016/j.neulet.2012.04.021openalex-snapshot

Involvement of P2Y13 receptor in suppression of neuronal differentiation

inferred← citeshttps://doi.org/10.1016/j.neulet.2012.08.088openalex-snapshot

Neuropathic pain and reactive gliosis are reversed by dialdehydic compound in neuropathic pain rat models

inferred← citeshttps://doi.org/10.1016/j.neulet.2013.09.056openalex-snapshot

Nucleotide signaling in astrogliosis

inferred← citeshttps://doi.org/10.1016/j.neures.2013.10.010openalex-snapshot

Multifaceted neuro-regenerative activities of human dental pulp stem cells for functional recovery after spinal cord injury

inferred← citeshttps://doi.org/10.1016/j.neurobiolaging.2011.09.040openalex-snapshot

In vivo P2X7 inhibition reduces amyloid plaques in Alzheimer's disease through GSK3β and secretases

inferred← citeshttps://doi.org/10.1016/j.neuron.2012.09.024openalex-snapshot

Neuromodulation by Extracellular ATP and P2X Receptors in the CNS

inferred← citeshttps://doi.org/10.1016/j.neuron.2017.07.010openalex-snapshot

Neuroimmunology of Traumatic Brain Injury: Time for a Paradigm Shift

inferred← citeshttps://doi.org/10.1016/j.neuron.2021.11.027openalex-snapshot

A sensitive GRAB sensor for detecting extracellular ATP in vitro and in vivo

inferred← citeshttps://doi.org/10.1016/j.neuropharm.2013.07.034openalex-snapshot

Three Ca2+ channel inhibitors in combination limit chronic secondary degeneration following neurotrauma

inferred← citeshttps://doi.org/10.1016/j.neuropharm.2015.05.031openalex-snapshot

An introduction to the roles of purinergic signalling in neurodegeneration, neuroprotection and neuroregeneration

inferred← citeshttps://doi.org/10.1016/j.neuropharm.2015.09.002openalex-snapshot

Nucleotides in neuroregeneration and neuroprotection

inferred← citeshttps://doi.org/10.1016/j.neuropharm.2022.109333openalex-snapshot

Extracellular ATP: A powerful inflammatory mediator in the central nervous system

inferred← citeshttps://doi.org/10.1016/j.neuropharm.2025.110783openalex-snapshot

Purinergic signaling in Stroke and Multiple Sclerosis: Prospects for therapies

inferred← citeshttps://doi.org/10.1016/j.neuropharm.2026.110949openalex-snapshot

A bioluminescent ratiometric sensor for the measurement of extracellular ATP concentration in inflammation and cancer

inferred← citeshttps://doi.org/10.1016/j.neuroscience.2011.06.083openalex-snapshot

Central sensitization of nociceptive neurons in rat medullary dorsal horn involves purinergic P2X7 receptors

inferred← citeshttps://doi.org/10.1016/j.neuroscience.2013.03.010openalex-snapshot

Improved axonal regeneration after spinal cord injury in mice with conditional deletion of ephrin B2 under the GFAP promoter

inferred← citeshttps://doi.org/10.1016/j.neuroscience.2016.10.005openalex-snapshot

Specific combinations of ion channel inhibitors reduce excessive Ca2+ influx as a consequence of oxidative stress and increase neuronal and glial cell viability in vitro

inferred← citeshttps://doi.org/10.1016/j.neuroscience.2022.06.039openalex-snapshot

Brain Damage-linked ATP Promotes P2X7 Receptors Mediated Pineal N-acetylserotonin Release

inferred← citeshttps://doi.org/10.1016/j.nurt.2010.07.002openalex-snapshot

Role of Microglia in Neurotrauma

inferred← citeshttps://doi.org/10.1016/j.nurt.2010.07.003openalex-snapshot

Reactive Astrocytes As Therapeutic Targets for CNS Disorders

inferred← citeshttps://doi.org/10.1016/j.pain.2013.06.022openalex-snapshot

Glia and pain: Is chronic pain a gliopathy?

inferred← citeshttps://doi.org/10.1016/j.pharep.2014.01.005openalex-snapshot

Protection of differentiated neuronal NG108-15 cells from P2X7 receptor-mediated toxicity by taurine

inferred← citeshttps://doi.org/10.1016/j.pharmthera.2005.06.002openalex-snapshot

Involvement of P2 receptors in the growth and survival of neurons in the CNS

inferred← citeshttps://doi.org/10.1016/j.pharmthera.2024.108700openalex-snapshot

Overview of the role of purinergic signaling and insights into its role in cancer therapy

inferred← citeshttps://doi.org/10.1016/j.pneurobio.2005.12.004openalex-snapshot

Experimental strategies to promote spinal cord regeneration—an integrative perspective

inferred← citeshttps://doi.org/10.1016/j.pneurobio.2006.03.007openalex-snapshot

P2X7 receptors in the nervous system

inferred← citeshttps://doi.org/10.1016/j.pneurobio.2007.10.004openalex-snapshot

Do ATP and NO interact in the CNS?

inferred← citeshttps://doi.org/10.1016/j.pneurobio.2011.08.006openalex-snapshot

Purinergic signalling: From normal behaviour to pathological brain function

inferred← citeshttps://doi.org/10.1016/j.pneurobio.2013.11.002openalex-snapshot

From basics to clinical: A comprehensive review on spinal cord injury

inferred← citeshttps://doi.org/10.1016/j.pneurobio.2014.02.006openalex-snapshot

Remyelination after spinal cord injury: Is it a target for repair?

inferred← citeshttps://doi.org/10.1016/j.pneurobio.2024.102693openalex-snapshot

Purinergic-associated immune responses in neurodegenerative diseases

inferred← citeshttps://doi.org/10.1016/j.redox.2022.102247openalex-snapshot

Peroxynitrite nitration of Tyr 56 in Hsp90 induces PC12 cell death through P2X7R-dependent PTEN activation

inferred← citeshttps://doi.org/10.1016/j.rvsc.2014.03.004openalex-snapshot

Changes in purine levels associated with cellular brain injury in gerbils experimentally infected with Neospora caninum

inferred← citeshttps://doi.org/10.1016/j.semcdb.2011.02.011openalex-snapshot

Neuroglial interactions mediated by purinergic signalling in the pathophysiology of CNS disorders

inferred← citeshttps://doi.org/10.1016/j.smim.2022.101629openalex-snapshot

Immune response after central nervous system injury

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