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A phase 1 clinical trial of nerve growth factor gene therapy for Alzheimer disease
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1002/cne.902750205openalex-snapshot
Nucleus basalis (Ch4) and cortical cholinergic innervation in the human brain: Observations based on the distribution of acetylcholinesterase and choline acetyltransferase
inferredcites →https://doi.org/10.1002/cne.903490110openalex-snapshot
Implants of polymer‐encapsulated human NGF‐secreting cells in the nonhuman primate: Rescue and sprouting of degenerating cholinergic basal forebrain neurons
inferredcites →https://doi.org/10.1016/0304-3940(86)90186-2openalex-snapshot
Cholinergic denervation of the rat hippocampus by fimbrial transection leads to a transient accumulation of nerve growth factor (NGF) without change in mRNANGF content
inferredcites →https://doi.org/10.1016/0304-3940(94)90121-xopenalex-snapshot
Synaptic and neuritic alterations during the progression of Alzheimer's disease
inferredcites →https://doi.org/10.1016/s0028-3932(03)00090-3openalex-snapshot
Does the cerebellum contribute to specific aspects of attention?
inferredcites →https://doi.org/10.1016/s0306-4522(02)00024-6openalex-snapshot
Neuronal plasticity of interrelated cerebellar and cortical networks
inferredcites →https://doi.org/10.1016/s0896-6273(03)00288-5openalex-snapshot
Lesions of the Basal Forebrain Cholinergic System Impair Task Acquisition and Abolish Cortical Plasticity Associated with Motor Skill Learning
inferredcites →https://doi.org/10.1016/s1474-4422(02)00006-6openalex-snapshot
Growth-factor gene therapy for neurodegenerative disorders
inferredcites →https://doi.org/10.1017/s1461145701002528openalex-snapshot
Brain metabolic and clinical effects of rivastigmine in Alzheimer's disease
inferredcites →https://doi.org/10.1038/329065a0openalex-snapshot
Amelioration of cholinergic neuron atrophy and spatial memory impairment in aged rats by nerve growth factor
inferredcites →https://doi.org/10.1038/nm850openalex-snapshot
Direct brain infusion of glial cell line–derived neurotrophic factor in Parkinson disease
inferredcites →https://doi.org/10.1056/nejm199911253412207openalex-snapshot
Treatment of Alzheimer's Disease
inferredcites →https://doi.org/10.1073/pnas.181219298openalex-snapshot
Failed retrograde transport of NGF in a mouse model of Down's syndrome: Reversal of cholinergic neurodegenerative phenotypes following NGF infusion
inferredcites →https://doi.org/10.1073/pnas.192442999openalex-snapshot
Nerve growth factor and galantamine ameliorate early signs of neurodegeneration in anti-nerve growth factor mice
inferredcites →https://doi.org/10.1073/pnas.92.10.4621openalex-snapshot
Bridging grafts and transient nerve growth factor infusions promote long-term central nervous system neuronal rescue and partial functional recovery.
inferredcites →https://doi.org/10.1073/pnas.96.19.10893openalex-snapshot
Age-associated neuronal atrophy occurs in the primate brain and is reversible by growth factor gene therapy
inferredcites →https://doi.org/10.1073/pnas.98.4.1941openalex-snapshot
Nontropic actions of neurotrophins: Subcortical nerve growth factor gene delivery reverses age-related degeneration of primate cortical cholinergic innervation
inferredcites →https://doi.org/10.1101/lm.69204openalex-snapshot
The Cholinergic Lesion of Alzheimer's Disease: Pivotal Factor or Side Show?
inferredcites →https://doi.org/10.1126/science.1065057openalex-snapshot
Regulation of Cell Survival by Secreted Proneurotrophins
inferredcites →https://doi.org/10.1126/science.279.5357.1714openalex-snapshot
Cortical Map Reorganization Enabled by Nucleus Basalis Activity
inferredcites →https://doi.org/10.1126/science.3201248openalex-snapshot
Grafting Genetically Modified Cells to the Damaged Brain: Restorative Effects of NGF Expression
inferredcites →https://doi.org/10.1126/science.3306916openalex-snapshot
The Nerve Growth Factor 35 Years Later
inferredcites →https://doi.org/10.1126/science.7046051openalex-snapshot
The Cholinergic Hypothesis of Geriatric Memory Dysfunction
inferredcites →https://doi.org/10.1136/bmj.2.6150.1457openalex-snapshot
Correlation of cholinergic abnormalities with senile plaques and mental test scores in senile dementia.
inferredcites →https://doi.org/10.1146/annurev.pharmtox.43.100901.140248openalex-snapshot
Alzheimer's Disease: Molecular Understanding Predicts Amyloid-Based Therapeutics
inferredcites →https://doi.org/10.1159/000017069openalex-snapshot
Intracerebroventricular Infusion of Nerve Growth Factor in Three Patients with Alzheimer’s Disease
inferredcites →https://doi.org/10.1176/ajp.141.11.1356openalex-snapshot
A new rating scale for Alzheimer's disease
inferredcites →https://doi.org/10.1176/ajp.151.3.390openalex-snapshot
A longitudinal study of Alzheimer's disease: measurement, rate, and predictors of cognitive deterioration
inferredcites →https://doi.org/10.1212/01.wnl.0000096376.03678.c1openalex-snapshot
Idebenone treatment fails to slow cognitive decline in Alzheimer’s disease
inferredcites →https://doi.org/10.1212/01.wnl.0000134650.91974.1aopenalex-snapshot
Surgical and hardware complications of subthalamic stimulation
inferredcites →https://doi.org/10.1212/wnl.34.7.939openalex-snapshot
Clinical diagnosis of Alzheimer's disease
inferredcites →https://doi.org/10.1523/jneurosci.06-08-02155.1986openalex-snapshot
Nerve growth factor promotes survival of septal cholinergic neurons after fimbrial transections
inferredcites →https://doi.org/10.1523/jneurosci.10-11-03604.1990openalex-snapshot
Nerve growth factor infusion in the primate brain reduces lesion- induced cholinergic neuronal degeneration
inferredcites →https://doi.org/10.1523/jneurosci.15-04-02819.1995openalex-snapshot
Somatic gene transfer of NGF to the aged brain: behavioral and morphological amelioration
inferredcites →https://doi.org/10.3171/jns.2005.102.2.0216openalex-snapshot
Improvement of bilateral motor functions in patients with Parkinson disease through the unilateral intraputaminal infusion of glial cell line—derived neurotrophic factor
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Incoming claims: where this work appears in other papers’ reference lists and arguments.
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inferred← citeshttps://doi.org/10.1007/978-3-540-69960-6_76openalex-snapshot
Image Guided Functional Neurosurgery
inferred← citeshttps://doi.org/10.1007/978-3-540-87941-1_7openalex-snapshot
Axonal Transport of Neurotrophic Signals: An Achilles' Heel for Neurodegeneration?
inferred← citeshttps://doi.org/10.1007/978-3-540-88633-4_23openalex-snapshot
Viral Vectors for in Vivo Gene Transfer
inferred← citeshttps://doi.org/10.1007/978-3-642-03584-5_5openalex-snapshot
Nanotechnology, Nanostructure, and Nervous System Disorders
inferred← citeshttps://doi.org/10.1007/978-88-470-1643-9_4openalex-snapshot
Clinical Applications of Gene Therapy
inferred← citeshttps://doi.org/10.1007/978-90-481-9075-1_24openalex-snapshot
Regenerative Medicine in the Central Nervous System: Stem Cell-Based Gene-Therapy
inferred← citeshttps://doi.org/10.1007/978-94-007-5690-8_27openalex-snapshot
Regenerative Medicine in the Central Nervous System: Stem Cell-Based Cell- and Gene-Therapy
inferred← citeshttps://doi.org/10.1007/978-94-007-6803-1_4openalex-snapshot
Regulatory Crosstalk Analysis of Biochemical Networks in the Hippocampus and Nucleus Accumbens
inferred← citeshttps://doi.org/10.1007/978-94-007-7196-3_2openalex-snapshot
Human Neural Stem Cell-Based Cell- and Gene-Therapy for Neurological Diseases
inferred← citeshttps://doi.org/10.1007/978-981-10-3701-6_13openalex-snapshot
Hype and Hopes of Stem Cell Research in Neurodegenerative Diseases
inferred← citeshttps://doi.org/10.1007/978-981-15-2848-4_64-2openalex-snapshot
Developing a Neuroprosthesis for Memory: The Past, Present, and Future
inferred← citeshttps://doi.org/10.1007/978-981-15-2848-4_64-3openalex-snapshot
Developing a Neuroprosthesis for Memory: The Past, Present, and Future
inferred← citeshttps://doi.org/10.1007/978-981-16-5540-1_64openalex-snapshot
Developing a Neuroprosthesis for Memory: The Past, Present, and Future
inferred← citeshttps://doi.org/10.1007/978-981-19-3949-5_40-1openalex-snapshot
A Comprehensive Review on the Newer Therapeutic Approaches in Treating Alzheimer’s Disease
inferred← citeshttps://doi.org/10.1007/978-981-97-6001-5_8openalex-snapshot
Harnessing the Power of Osmolytes for Industrial and Pharmaceutical Applications
inferred← citeshttps://doi.org/10.1007/978-981-99-7557-0_40openalex-snapshot
A Comprehensive Review on the Newer Therapeutic Approaches in Treating Alzheimer’s Disease
inferred← citeshttps://doi.org/10.1007/bf02700624openalex-snapshot
Neuroprotection against neurodegenerative diseases
inferred← citeshttps://doi.org/10.1007/s00005-015-0376-4openalex-snapshot
Neurotrophic Factors and Their Potential Applications in Tissue Regeneration
inferred← citeshttps://doi.org/10.1007/s00018-008-8053-yopenalex-snapshot
Behavior of neural stem cells in the Alzheimer brain
inferred← citeshttps://doi.org/10.1007/s00018-008-8159-2openalex-snapshot
Galanin – 25 years with a multitalented neuropeptide
inferred← citeshttps://doi.org/10.1007/s00018-013-1529-4openalex-snapshot
Choroid plexus implants rescue Alzheimer’s disease-like pathologies by modulating amyloid-β degradation
inferred← citeshttps://doi.org/10.1007/s00018-017-2501-5openalex-snapshot
Transfection of primary brain capillary endothelial cells for protein synthesis and secretion of recombinant erythropoietin: a strategy to enable protein delivery to the brain
inferred← citeshttps://doi.org/10.1007/s00044-012-0119-6openalex-snapshot
In silico biological activity of steroids from the marine sponge Axinella carteri
inferred← citeshttps://doi.org/10.1007/s00103-015-2245-zopenalex-snapshot
Genetisch modifizierte Zellen zur Therapie verschiedener Erkrankungen
inferred← citeshttps://doi.org/10.1007/s00109-006-0114-9openalex-snapshot
Enhanced brain targeting efficiency of intranasally administered plasmid DNA: an alternative route for brain gene therapy
inferred← citeshttps://doi.org/10.1007/s00109-006-0118-5openalex-snapshot
Divide or unite—a novel molecular switch in endometrial carcinoma
inferred← citeshttps://doi.org/10.1007/s00213-008-1365-7openalex-snapshot
Pharmaceutical treatment for cognitive deficits in Alzheimer’s disease and other neurodegenerative conditions: exploring new territory using traditional tools and established maps
inferred← citeshttps://doi.org/10.1007/s00259-005-1960-3openalex-snapshot
Human gene therapy and imaging in neurological diseases
inferred← citeshttps://doi.org/10.1007/s00401-011-0878-zopenalex-snapshot
Opportunities and challenges in developing Alzheimer disease therapeutics
inferred← citeshttps://doi.org/10.1007/s00417-018-3931-yopenalex-snapshot
NGF protects corneal, retinal, and cutaneous tissues/cells from phototoxic effect of UV exposure
inferred← citeshttps://doi.org/10.1007/s00441-007-0488-1openalex-snapshot
Human stem cells for CNS repair
inferred← citeshttps://doi.org/10.1007/s00441-013-1585-yopenalex-snapshot
Neurotrophic molecules in the treatment of neurodegenerative disease with focus on the retina: status and perspectives
inferred← citeshttps://doi.org/10.1007/s00702-009-0250-9openalex-snapshot
Metabolites of sesamin, a major lignan in sesame seeds, induce neuronal differentiation in PC12 cells through activation of ERK1/2 signaling pathway
inferred← citeshttps://doi.org/10.1007/s10072-023-06684-1openalex-snapshot
Neurotrophin mimetics and tropomyosin kinase receptors: a futuristic pharmacological tool for Parkinson’s
inferred← citeshttps://doi.org/10.1007/s10118-011-1047-5openalex-snapshot
What can we learn from virus in designing nonviral gene vectors
inferred← citeshttps://doi.org/10.1007/s10295-010-0805-7openalex-snapshot
Bacteria-induced static batch fungal fermentation of the diterpenoid cyathin A3, a small-molecule inducer of nerve growth factor
inferred← citeshttps://doi.org/10.1007/s11010-010-0386-9openalex-snapshot
Angiostatic effects of K252a, a Trk inhibitor, in murine brain capillary endothelial cells
inferred← citeshttps://doi.org/10.1007/s11011-008-9084-7openalex-snapshot
Age-related changes of NGF, BDNF, parvalbumin and neuronal nitric oxide synthase immunoreactivity in the mouse hippocampal CA1 sector
inferred← citeshttps://doi.org/10.1007/s11033-021-06968-9openalex-snapshot
Therapeutic potential of neurotrophic factors in Alzheimer’s Disease
inferred← citeshttps://doi.org/10.1007/s11055-024-01582-1openalex-snapshot
Intranasal delivery of human Wharton’s jelly-derived mesenchymal stem cells alleviates Aβ-induced Alzheimer’s symptoms in rat models by regulating neurotrophic and apoptotic factors
inferred← citeshttps://doi.org/10.1007/s11064-006-9209-5openalex-snapshot
Nerve Growth Factor Differentially Affects Spatial and Recognition Memory in Aged Rats
inferred← citeshttps://doi.org/10.1007/s11064-007-9335-8openalex-snapshot
Beta-Amyloid Toxicity in Embryonic Rat Astrocytes
inferred← citeshttps://doi.org/10.1007/s11064-011-0592-1openalex-snapshot
BDNF-, IGF-1- and GDNF-Secreting Human Neural Progenitor Cells Rescue Amyloid β-Induced Toxicity in Cultured Rat Septal Neurons
inferred← citeshttps://doi.org/10.1007/s11064-016-1829-9openalex-snapshot
The Emerging Therapeutic Role of NGF in Alzheimer’s Disease
inferred← citeshttps://doi.org/10.1007/s11094-021-02420-1openalex-snapshot
Dose-Dependent Effect of Nerve Growth Factor Mimetic GK-2 in a Wistar Rat Diabetes Model
inferred← citeshttps://doi.org/10.1007/s11418-020-01431-8openalex-snapshot
The search for, and chemistry and mechanism of, neurotrophic natural products
inferred← citeshttps://doi.org/10.1007/s11481-013-9520-2openalex-snapshot
Role of Neurotrophic Factor Alterations in the Neurodegenerative Process in HIV Associated Neurocognitive Disorders
inferred← citeshttps://doi.org/10.1007/s11845-026-04624-4openalex-snapshot
Neuroplasticity after traumatic brain injury: mechanisms and clinical implications
inferred← citeshttps://doi.org/10.1007/s11940-006-0012-zopenalex-snapshot
Current and future treatments in progressive supranuclear palsy
inferred← citeshttps://doi.org/10.1007/s12010-015-1723-yopenalex-snapshot
PEGylation of Polypropylenimine Dendrimer with Alkylcarboxylate Chain Linkage to Improve DNA Delivery and Cytotoxicity
inferred← citeshttps://doi.org/10.1007/s12015-013-9443-6openalex-snapshot
Progress in Stem Cell Therapy for Major Human Neurological Disorders
inferred← citeshttps://doi.org/10.1007/s12015-013-9474-zopenalex-snapshot
Approaches for Neural Tissue Regeneration
inferred← citeshttps://doi.org/10.1007/s12031-007-9022-xopenalex-snapshot
Transplantation of NGF-Gene-Modified Bone Marrow Stromal Cells into a Rat Model of Alzheimer’ Disease
inferred← citeshttps://doi.org/10.1007/s12031-013-9951-5openalex-snapshot
1H-MRS Assessment of the Therapeutic Effect of Bilateral Intraventricular BDNF Infusion into APP/PS1 Double Transgenic Mice
inferred← citeshttps://doi.org/10.1007/s12035-007-8000-1openalex-snapshot
Tracking TrkA’s Trafficking: NGF Receptor Trafficking Controls NGF Receptor Signaling
inferred← citeshttps://doi.org/10.1007/s12035-012-8310-9openalex-snapshot
Nerve Growth Factor and Alzheimer's Disease: New Facts for an Old Hypothesis
inferred← citeshttps://doi.org/10.1007/s12035-014-8640-xopenalex-snapshot
Neural Stem Cell Transplants Improve Cognitive Function Without Altering Amyloid Pathology in an APP/PS1 Double Transgenic Model of Alzheimer’s Disease
inferred← citeshttps://doi.org/10.1007/s12035-014-9069-yopenalex-snapshot
Designer Self-Assemble Peptides Maximize the Therapeutic Benefits of Neural Stem Cell Transplantation for Alzheimer’s Disease via Enhancing Neuron Differentiation and Paracrine Action
inferred← citeshttps://doi.org/10.1007/s12035-016-0214-7openalex-snapshot
Neurotrophin Signaling and Stem Cells—Implications for Neurodegenerative Diseases and Stem Cell Therapy
inferred← citeshttps://doi.org/10.1007/s12035-019-01680-zopenalex-snapshot
Neurotrophic Factors Mediated Activation of Astrocytes Ameliorate Memory Loss by Amyloid Clearance after Transplantation of Lineage Negative Stem Cells
inferred← citeshttps://doi.org/10.1007/s12035-023-03328-5openalex-snapshot
RETRACTED ARTICLE: Exploring the Therapeutic Effect of Neurotrophins and Neuropeptides in Neurodegenerative Diseases: at a Glance
inferred← citeshttps://doi.org/10.1007/s12035-023-03671-7openalex-snapshot
Current Insights of Nanocarrier-Mediated Gene Therapeutics to Treat Potential Impairment of Amyloid Beta Protein and Tau Protein in Alzheimer’s Disease
inferred← citeshttps://doi.org/10.1007/s12035-024-04285-3openalex-snapshot
From Lab Bench to Hope: Emerging Gene Therapies in Clinical Trials for Alzheimer’s Disease
inferred← citeshttps://doi.org/10.1007/s12035-026-05901-0openalex-snapshot
Advancements in Gene Delivery using Nucleic Acid Loaded Nanoparticles for Region Specific Delivery in Alzheimer’s Disease
inferred← citeshttps://doi.org/10.1007/s12152-015-9234-7openalex-snapshot
Cognitive Enhancement and the Principle of Need
inferred← citeshttps://doi.org/10.1007/s12603-010-0103-0openalex-snapshot
Progress in the development of new drugs in Alzheimer’s disease
inferred← citeshttps://doi.org/10.1007/s12603-011-0012-xopenalex-snapshot
Progress in the development of new drugs in Alzheimer's disease
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