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Abrogation of nuclear receptors Nr4a3 andNr4a1 leads to development of acute myeloid leukemia

https://doi.org/10.1038/nm1579
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1016/0896-6273(88)90138-9openalex-snapshot
Nerve growth factor induces a gene homologous to the glucocorticoid receptor gene
inferredcites →https://doi.org/10.1016/j.ccr.2004.10.015openalex-snapshot
MOZ-TIF2, but not BCR-ABL, confers properties of leukemic stem cells to committed murine hematopoietic progenitors
inferredcites →https://doi.org/10.1016/s0092-8674(01)00188-xopenalex-snapshot
Chronic Myeloid Leukemia with Increased Granulocyte Progenitors in Mice Lacking JunB Expression in the Myeloid Lineage
inferredcites →https://doi.org/10.1016/s1074-7613(00)80587-7openalex-snapshot
Mice Defective in Two Apoptosis Pathways in the Myeloid Lineage Develop Acute Myeloblastic Leukemia
inferredcites →https://doi.org/10.1038/85820openalex-snapshot
Dominant-negative mutations of CEBPA, encoding CCAAT/enhancer binding protein-α (C/EBPα), in acute myeloid leukemia
inferredcites →https://doi.org/10.1038/86515openalex-snapshot
AML1–ETO downregulates the granulocytic differentiation factor C/EBPα in t(8;21) myeloid leukemia
inferredcites →https://doi.org/10.1038/ng1361openalex-snapshot
Acute myeloid leukemia induced by graded reduction of a lineage-specific transcription factor, PU.1
inferredcites →https://doi.org/10.1038/ng1898openalex-snapshot
Essential role of Jun family transcription factors in PU.1 knockdown–induced leukemic stem cells
inferredcites →https://doi.org/10.1038/nm1160openalex-snapshot
Inhibitors of histone deacetylases induce tumor-selective apoptosis through activation of the death receptor pathway
inferredcites →https://doi.org/10.1038/nm1161openalex-snapshot
Tumor-selective action of HDAC inhibitors involves TRAIL induction in acute myeloid leukemia cells
inferredcites →https://doi.org/10.1038/nrc989openalex-snapshot
Disruption of differentiation in human cancer: AML shows the way
inferredcites →https://doi.org/10.1038/sj.onc.1204639openalex-snapshot
Molecular mechanisms of leukemogenesis mediated by MLL fusion proteins
inferredcites →https://doi.org/10.1073/pnas.0400930101openalex-snapshot
Identification of genes that synergize with Cbfb-MYH11 in the pathogenesis of acute myeloid leukemia
inferredcites →https://doi.org/10.1073/pnas.051003198openalex-snapshot
Akt phosphorylates and regulates the orphan nuclear receptor Nur77
inferredcites →https://doi.org/10.1073/pnas.171321298openalex-snapshot
AML1-ETO expression is directly involved in the development of acute myeloid leukemia in the presence of additional mutations
inferredcites →https://doi.org/10.1073/pnas.182552499openalex-snapshot
Epstein–Barr virus EBNA2 blocks Nur77- mediated apoptosis
inferredcites →https://doi.org/10.1073/pnas.85.22.8444openalex-snapshot
A gene inducible by serum growth factors encodes a member of the steroid and thyroid hormone receptor superfamily.
inferredcites →https://doi.org/10.1074/jbc.m302167200openalex-snapshot
Identification of the Antineoplastic Agent 6-Mercaptopurine as an Activator of the Orphan Nuclear Hormone Receptor Nurr1
inferredcites →https://doi.org/10.1074/jbc.m502606200openalex-snapshot
Induction of NR4A Orphan Nuclear Receptor Expression in Macrophages in Response to Inflammatory Stimuli
inferredcites →https://doi.org/10.1093/emboj/cdg620openalex-snapshot
Transcriptional activation of known and novel apoptotic pathways by Nur77 orphan steroid receptor
inferredcites →https://doi.org/10.1101/gad.1143403openalex-snapshot
Similar MLL-associated leukemias arising from self-renewing stem cells and short-lived myeloid progenitors
inferredcites →https://doi.org/10.1126/science.1925541openalex-snapshot
Identification of the DNA Binding Site for NGFI-B by Genetic Selection in Yeast
inferredcites →https://doi.org/10.1126/science.7624775openalex-snapshot
Unimpaired Thymic and Peripheral T Cell Death in Mice Lacking the Nuclear Receptor NGFI-B (Nur77)
inferredcites →https://doi.org/10.1128/mcb.14.5.3469openalex-snapshot
Endocrine and Neurogenic Regulation of the Orphan Nuclear Receptors Nur77 and Nurr-1 in the Adrenal Glands
inferredcites →https://doi.org/10.1128/mcb.22.3.935-945.2002openalex-snapshot
The Nuclear Receptor Nor-1 Is Essential for Proliferation of the Semicircular Canals of the Mouse Inner Ear
inferredcites →https://doi.org/10.1161/01.es.0000050921.53008.47openalex-snapshot
Neuron-Derived Orphan Receptor-1 (NOR-1) Modulates Vascular Smooth Muscle Cell Proliferation
inferredcites →https://doi.org/10.1182/blood-2002-04-1288openalex-snapshot
The myeloid master regulator transcription factor PU.1 is inactivated by AML1-ETO in t(8;21) myeloid leukemia
inferredcites →https://doi.org/10.1182/blood.v81.4.883.883openalex-snapshot
Detection of DNA rearrangements in the AML1 and ETO loci and of an AML1/ETO fusion mRNA in patients with t(8;21) acute myeloid leukemia
inferredcites →https://doi.org/10.1210/endo.139.5.5969openalex-snapshot
Antisense TR3 Orphan Receptor Can Increase Prostate Cancer Cell Viability with Etoposide Treatment1
inferredcites →https://doi.org/10.1210/me.9.12.1692openalex-snapshot
The isolation and characterization of MINOR, a novel mitogen-inducible nuclear orphan receptor

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.4189784openalex-extracted
The Small Molecular Compound CC1007 Suppresses Multiple Myeloma Via Upregulation of Nur77
inferred← citeshttps://doi.org/10.1002/art.34399openalex-snapshot
Orphan nuclear receptor NR4A2 induces synoviocyte proliferation, invasion, and matrix metalloproteinase 13 transcription
inferred← citeshttps://doi.org/10.1002/art.40772openalex-snapshot
Beyond Autoantibodies: Biologic Roles of Human Autoreactive B Cells in Rheumatoid Arthritis Revealed by RNA‐Sequencing
inferred← citeshttps://doi.org/10.1002/cbf.3814openalex-snapshot
Transient downregulation of NR4A1 leads to impaired osteoblast differentiation through the TGF‐ß pathway, and Elesclomol (STA‐4783) rescues this phenotype
inferred← citeshttps://doi.org/10.1002/dvdy.21860openalex-snapshot
Drosophila DHR38 nuclear receptor is required for adult cuticle integrity at eclosion
inferred← citeshttps://doi.org/10.1002/dvdy.24244openalex-snapshot
The C. elegans NR4A nuclear receptor gene nhr‐6 promotes cell cycle progression in the spermatheca lineage
inferred← citeshttps://doi.org/10.1002/dvg.20646openalex-snapshot
A functional NR4A nuclear receptor DNA‐binding domain is required for organ development in Caenorhabditis elegans
inferred← citeshttps://doi.org/10.1002/gcc.21991openalex-snapshot
Differential copy number aberrations in novel candidate genes associated with progression from in situ to invasive ductal carcinoma of the breast
inferred← citeshttps://doi.org/10.1002/gcc.23118openalex-snapshot
NR4A3 fusions characterize a distinctive peritoneal mesothelial neoplasm of uncertain biological potential with pure adenomatoid/microcystic morphology
inferred← citeshttps://doi.org/10.1002/ijc.24699openalex-snapshot
Identification of novel hub genes associated with liver metastasis of gastric cancer
inferred← citeshttps://doi.org/10.1002/jcb.21876openalex-snapshot
Differential transactivation by orphan nuclear receptor NOR1 and its fusion gene product EWS/NOR1: Possible involvement of poly(ADP‐ribose) polymerase I, PARP‐1
inferred← citeshttps://doi.org/10.1002/mc.22662openalex-snapshot
The nuclear orphan receptor NR4A1 regulates β1‐integrin expression in pancreatic and colon cancer cells and can be targeted by NR4A1 antagonists
inferred← citeshttps://doi.org/10.1002/path.2445openalex-snapshot
The EWSR1/NR4A3 fusion protein of extraskeletal myxoid chondrosarcoma activates the PPARG nuclear receptor gene
inferred← citeshttps://doi.org/10.1002/stem.1747openalex-snapshot
Deficiency of the NR4A Orphan Nuclear Receptor NOR1 in Hematopoietic Stem Cells Accelerates Atherosclerosis
inferred← citeshttps://doi.org/10.1002/stem.1852openalex-snapshot
The Orphan Nuclear Receptor NR4A1 Specifies a Distinct Subpopulation of Quiescent Myeloid-Biased Long-Term HSCs
inferred← citeshttps://doi.org/10.1007/978-1-4939-1393-0_26openalex-snapshot
NR4A Orphan Receptors as Drug Targets
inferred← citeshttps://doi.org/10.1007/978-1-4939-1393-0_3openalex-snapshot
Roles of Apoptosis-Regulating Bcl-2 Family Genes in AML
inferred← citeshttps://doi.org/10.1007/978-1-4939-6539-7_7openalex-snapshot
Transcriptome and Proteome Analyses of TNFAIP8 Knockdown Cancer Cells Reveal New Insights into Molecular Determinants of Cell Survival and Tumor Progression
inferred← citeshttps://doi.org/10.1007/978-3-031-96376-6_9openalex-snapshot
Transcription Factors in Leydig Cells
inferred← citeshttps://doi.org/10.1007/978-3-642-36229-3_6openalex-snapshot
A Personalized Molecular Pathogenesis of MDS
inferred← citeshttps://doi.org/10.1007/978-90-481-2298-1_11openalex-snapshot
Role of Members of the Nur (NR4A) Transcription Factors in Dopamine-Related Neurodegenerative and Neuropsychiatric Disorders
inferred← citeshttps://doi.org/10.1007/978-90-481-3303-1_1openalex-snapshot
Nuclear Receptors an Introductory Overview
inferred← citeshttps://doi.org/10.1007/s00011-021-01533-3openalex-snapshot
Dihydroartemisinin alleviates AngII-induced vascular smooth muscle cell proliferation and inflammatory response by blocking the FTO/NR4A3 axis
inferred← citeshttps://doi.org/10.1007/s00277-022-04961-1openalex-snapshot
Functional association of NR4A3 downregulation with impaired differentiation in myeloid leukemogenesis
inferred← citeshttps://doi.org/10.1007/s00784-009-0260-xopenalex-snapshot
Gene expression profiles of dental follicle cells before and after osteogenic differentiation in vitro
inferred← citeshttps://doi.org/10.1007/s10549-016-3838-4openalex-snapshot
Validation of an oligo-gene signature for the prognostic stratification of ductal carcinoma in situ (DCIS)
inferred← citeshttps://doi.org/10.1007/s11060-019-03349-yopenalex-snapshot
Nuclear receptor 4A2 (NR4A2) is a druggable target for glioblastomas
inferred← citeshttps://doi.org/10.1007/s11926-020-00918-3openalex-snapshot
Current and Potential New Targets in Systemic Sclerosis Therapy: a New Hope
inferred← citeshttps://doi.org/10.1007/s12032-019-1289-6openalex-snapshot
Forced expression of NR4A3 induced the differentiation of human neuroblastoma-derived NB1 cells
inferred← citeshttps://doi.org/10.1007/s12035-016-9821-6openalex-snapshot
Kainic Acid Induces mTORC1-Dependent Expression of Elmo1 in Hippocampal Neurons
inferred← citeshttps://doi.org/10.1007/s12185-021-03284-7openalex-snapshot
Emergence of clone with PHF6 nonsense mutation in chronic myelomonocytic leukemia at relapse after allogeneic HCT
inferred← citeshttps://doi.org/10.1007/s12272-016-0803-zopenalex-snapshot
Transcriptional modulation of regulatory T cell development by novel regulators NR4As
inferred← citeshttps://doi.org/10.1007/s12640-016-9626-4openalex-snapshot
Altered NR4A Subfamily Gene Expression Level in Peripheral Blood of Parkinson’s and Alzheimer’s Disease Patients
inferred← citeshttps://doi.org/10.1007/s13277-015-3947-4openalex-snapshot
Ruxolitinib induces autophagy in chronic myeloid leukemia cells
inferred← citeshttps://doi.org/10.1016/b978-0-12-800177-6.00007-4openalex-snapshot
Dual Roles of Orphan Nuclear Receptor TR3/Nur77/NGFI-B in Mediating Cell Survival and Apoptosis
inferred← citeshttps://doi.org/10.1016/b978-1-4160-3431-5.00020-0openalex-snapshot
Nonrhabdomyosarcomas and Other Soft Tissue Tumors
inferred← citeshttps://doi.org/10.1016/b978-1-4557-5414-4.00060-7openalex-snapshot
10.1016/b978-1-4557-5414-4.00060-7
inferred← citeshttps://doi.org/10.1016/j.abb.2018.09.013openalex-snapshot
Long non-coding RNA BRE-AS1 represses non-small cell lung cancer cell growth and survival via up-regulating NR4A3
inferred← citeshttps://doi.org/10.1016/j.artere.2022.06.008openalex-snapshot
Nuclear receptor NOR-1 (Neuron-derived Orphan Receptor-1) in pathological vascular remodelling
inferred← citeshttps://doi.org/10.1016/j.arteri.2022.03.002openalex-snapshot
El receptor nuclear NOR-1 (Neuron-derived Orphan Receptor-1) en el remodelado vascular patológico
inferred← citeshttps://doi.org/10.1016/j.atherosclerosis.2020.02.009openalex-snapshot
Nuclear receptors in abdominal aortic aneurysms
inferred← citeshttps://doi.org/10.1016/j.bbcan.2025.189377openalex-snapshot
Combination therapy in cancer: The potential of tetrandrine as a polytherapy for acute myeloid leukemia
inferred← citeshttps://doi.org/10.1016/j.bbrc.2016.03.059openalex-snapshot
RIP3-dependent necrosis induced inflammation exacerbates atherosclerosis
inferred← citeshttps://doi.org/10.1016/j.bbrc.2024.150493openalex-snapshot
Chidamide induces cell cycle arrest via NR4A3/P21 axis upregulation to suppress relapsed and refractory acute myeloid leukemia
inferred← citeshttps://doi.org/10.1016/j.biocel.2013.04.026openalex-snapshot
The orphan nuclear receptor TR3/Nur77 regulates ER stress and induces apoptosis via interaction with TRAPγ
inferred← citeshttps://doi.org/10.1016/j.bioorg.2022.106217openalex-snapshot
CC1007, a small molecular compound, suppresses multiple myeloma via upregulation of Nur77
inferred← citeshttps://doi.org/10.1016/j.canlet.2011.06.016openalex-snapshot
Targeting apoptosis proteins in hematological malignancies
inferred← citeshttps://doi.org/10.1016/j.canlet.2012.09.022openalex-snapshot
Orphan receptor TR3 is essential for the maintenance of stem-like properties in gastric cancer cells
inferred← citeshttps://doi.org/10.1016/j.cbi.2014.10.021openalex-snapshot
Shikonin, a constituent of Lithospermum erythrorhizon exhibits anti-allergic effects by suppressing orphan nuclear receptor Nr4a family gene expression as a new prototype of calcineurin inhibitors in mast cells
inferred← citeshttps://doi.org/10.1016/j.cellsig.2014.11.009openalex-snapshot
The interplay of NR4A receptors and the oncogene–tumor suppressor networks in cancer
inferred← citeshttps://doi.org/10.1016/j.cellsig.2019.03.018openalex-snapshot
Ovarian tumor domain-containing ubiquitin aldehyde binding protein 1 inhibits inflammation by regulating Nur77 stability
inferred← citeshttps://doi.org/10.1016/j.celrep.2024.113786openalex-snapshot
RORα is required for expansion and memory maintenance of ILC1s via a lymph node-liver axis
inferred← citeshttps://doi.org/10.1016/j.crimmu.2022.02.001openalex-snapshot
Role of NR4A family members in myeloid cells and leukemia
inferred← citeshttps://doi.org/10.1016/j.ejmech.2020.112205openalex-snapshot
Discovery of orally active indirubin-3′-oxime derivatives as potent type 1 FLT3 inhibitors for acute myeloid leukemia
inferred← citeshttps://doi.org/10.1016/j.etap.2022.103866openalex-snapshot
Hematological effects of glyphosate in mice revealed by traditional toxicology and transcriptome sequencing
inferred← citeshttps://doi.org/10.1016/j.exphem.2013.11.015openalex-snapshot
Clonal-level responses of functionally distinct hematopoietic stem cells to trophic factors
inferred← citeshttps://doi.org/10.1016/j.febslet.2011.04.001openalex-snapshot
Virus-induced differential expression of nuclear receptors and coregulators in dendritic cells: Implication to interferon production
inferred← citeshttps://doi.org/10.1016/j.gene.2024.148292openalex-snapshot
Nur77 inhibition of β-catenin expression mediates Hepatoblastoma progression and enhances cisplatin's therapeutic effect
inferred← citeshttps://doi.org/10.1016/j.ijbiomac.2026.152939openalex-snapshot
High throughput screening of nuclear receptors identifies NR4A1 as a novel tumor suppressor in gallbladder cancer
inferred← citeshttps://doi.org/10.1016/j.jbc.2021.101240openalex-snapshot
Cytokine exposure mediates transcriptional activation of the orphan nuclear receptor Nur77 in hematopoietic cells
inferred← citeshttps://doi.org/10.1016/j.joca.2008.12.011openalex-snapshot
Global analysis of nuclear receptor expression and dysregulation in human osteoarthritic articular cartilage
inferred← citeshttps://doi.org/10.1016/j.jsbmb.2015.04.016openalex-snapshot
Nuclear receptor 4A (NR4A) family – orphans no more
inferred← citeshttps://doi.org/10.1016/j.leukres.2016.09.018openalex-snapshot
Possible role of intragenic DNA hypermethylation in gene silencing of the tumor suppressor gene NR4A3 in acute myeloid leukemia
inferred← citeshttps://doi.org/10.1016/j.mce.2008.08.023openalex-snapshot
FGF-8 stimulates the expression of NR4A orphan nuclear receptors in osteoblasts
inferred← citeshttps://doi.org/10.1016/j.mehy.2014.12.003openalex-snapshot
The NR4A nuclear receptors as potential targets for anti-aging interventions
inferred← citeshttps://doi.org/10.1016/j.molcel.2018.01.001openalex-snapshot
Nuclear Receptor Nur77 Facilitates Melanoma Cell Survival under Metabolic Stress by Protecting Fatty Acid Oxidation
inferred← citeshttps://doi.org/10.1016/j.molcel.2025.11.012openalex-snapshot
A nucleotide regulates NR4A1 status in gastric cancer
inferred← citeshttps://doi.org/10.1016/j.molimm.2011.04.017openalex-snapshot
Differential regulation of Nr4a subfamily nuclear receptors following mast cell activation
inferred← citeshttps://doi.org/10.1016/j.neulet.2007.09.032openalex-snapshot
Expression of FasL and its interaction with Fas are mediated by c-Jun N-terminal kinase (JNK) pathway in 6-OHDA-induced rat model of Parkinson disease
inferred← citeshttps://doi.org/10.1016/j.phymed.2020.153448openalex-snapshot
Z-Ligustilide Selectively Targets AML by Restoring Nuclear Receptors Nur77 and NOR-1-mediated Apoptosis and Differentiation
inferred← citeshttps://doi.org/10.1016/j.phymed.2022.154280openalex-snapshot
Celastrol upregulated ATG7 triggers autophagy via targeting Nur77 in colorectal cancer
inferred← citeshttps://doi.org/10.1016/j.placenta.2014.08.089openalex-snapshot
The NR4A receptors Nurr1 and Nur77 are increased in human placenta from women with gestational diabetes
inferred← citeshttps://doi.org/10.1016/j.placenta.2020.11.010openalex-snapshot
Expression of p57KIP2 reduces growth and invasion, and induces syncytialization in a human placental choriocarcinoma cell line, BeWo
inferred← citeshttps://doi.org/10.1016/j.yexcr.2014.08.032openalex-snapshot
Function of transcription factors at DNA lesions in DNA repair
inferred← citeshttps://doi.org/10.1016/j.yjmcc.2014.12.015openalex-snapshot
NOR-1 modulates the inflammatory response of vascular smooth muscle cells by preventing NFκB activation
inferred← citeshttps://doi.org/10.1016/j.yjmcc.2014.12.022openalex-snapshot
Neuron-derived orphan receptor 1: Working towards a common goal
inferred← citeshttps://doi.org/10.1016/j.yjmcc.2018.08.002openalex-snapshot
The nuclear receptor NOR-1 modulates redox homeostasis in human vascular smooth muscle cells
inferred← citeshttps://doi.org/10.1021/acs.jafc.7b02299openalex-snapshot
Ginsenoside 20(S)-Rh2 Induces Apoptosis and Differentiation of Acute Myeloid Leukemia Cells: Role of Orphan Nuclear Receptor Nur77
inferred← citeshttps://doi.org/10.1038/bcj.2013.68openalex-snapshot
Dual epigenetic targeting with panobinostat and azacitidine in acute myeloid leukemia and high-risk myelodysplastic syndrome
inferred← citeshttps://doi.org/10.1038/cdd.2008.48openalex-snapshot
Selective anticancer strategies via intervention of the death pathways relevant to cell transformation
inferred← citeshttps://doi.org/10.1038/cdd.2017.29openalex-snapshot
SUMO-triggered ubiquitination of NR4A1 controls macrophage cell death
inferred← citeshttps://doi.org/10.1038/leu.2008.392openalex-snapshot
The hematopoietic stem cell in chronic phase CML is characterized by a transcriptional profile resembling normal myeloid progenitor cells and reflecting loss of quiescence
inferred← citeshttps://doi.org/10.1038/leu.2012.239openalex-snapshot
Trisomy 12 CLLs progress through NOTCH1 mutations
inferred← citeshttps://doi.org/10.1038/leu.2012.366openalex-snapshot
HDAC inhibition by SNDX-275 (Entinostat) restores expression of silenced leukemia-associated transcription factors Nur77 and Nor1 and of key pro-apoptotic proteins in AML
inferred← citeshttps://doi.org/10.1038/leu.2013.275openalex-snapshot
The NR4A orphan nuclear receptors do not confer prednisolone resistance in pediatric acute lymphoblastic leukemia
inferred← citeshttps://doi.org/10.1038/leu.2016.268openalex-snapshot
Impact of combinatorial dysfunctions of Tet2 and Ezh2 on the epigenome in the pathogenesis of myelodysplastic syndrome
inferred← citeshttps://doi.org/10.1038/ncb2125openalex-snapshot
The orphan nuclear receptor Nurr1 restricts the proliferation of haematopoietic stem cells
inferred← citeshttps://doi.org/10.1038/nchembio.106openalex-snapshot
Cytosporone B is an agonist for nuclear orphan receptor Nur77
inferred← citeshttps://doi.org/10.1038/ncomms14420openalex-snapshot
Nur77 suppresses hepatocellular carcinoma via switching glucose metabolism toward gluconeogenesis through attenuating phosphoenolpyruvate carboxykinase sumoylation
inferred← citeshttps://doi.org/10.1038/ncomms4388openalex-snapshot
Nuclear receptor NR4A1 promotes breast cancer invasion and metastasis by activating TGF-β signalling
inferred← citeshttps://doi.org/10.1038/ni.2063openalex-snapshot
The transcription factor NR4A1 (Nur77) controls bone marrow differentiation and the survival of Ly6C− monocytes
inferred← citeshttps://doi.org/10.1038/ni.2520openalex-snapshot
Nr4a receptors are essential for thymic regulatory T cell development and immune homeostasis
inferred← citeshttps://doi.org/10.1038/nm.3777openalex-snapshot
Orphan nuclear receptor NR4A1 regulates transforming growth factor-β signaling and fibrosis
inferred← citeshttps://doi.org/10.1038/nrc2184openalex-snapshot
In Brief
inferred← citeshttps://doi.org/10.1038/onc.2011.448openalex-snapshot
Inhibition of β-catenin signaling by nongenomic action of orphan nuclear receptor Nur77
inferred← citeshttps://doi.org/10.1038/onc.2016.488openalex-snapshot
MLL-AF9 and MLL-AF4 oncofusion proteins bind a distinct enhancer repertoire and target the RUNX1 program in 11q23 acute myeloid leukemia
inferred← citeshttps://doi.org/10.1038/oncsis.2012.19openalex-snapshot
Genome-wide profiling reveals transcriptional repression of MYC as a core component of NR4A tumor suppression in acute myeloid leukemia
inferred← citeshttps://doi.org/10.1038/s41375-018-0174-1openalex-snapshot
Drug targeting of NR4A nuclear receptors for treatment of acute myeloid leukemia
inferred← citeshttps://doi.org/10.1038/s41388-022-02303-zopenalex-snapshot
Matriptase-2/NR4A3 axis switches TGF-β action toward suppression of prostate cancer cell invasion, tumor growth, and metastasis
inferred← citeshttps://doi.org/10.1038/s41388-026-03925-3openalex-snapshot
PROTAC-mediated targeting of IKKβ and NR4A1 for AML therapy
inferred← citeshttps://doi.org/10.1038/s41408-017-0005-zopenalex-snapshot
NR4A1 inhibition synergizes with ibrutinib in killing mantle cell lymphoma cells
inferred← citeshttps://doi.org/10.1038/s41416-022-01796-5openalex-snapshot
Molecular mechanisms by which splice modulator GEX1A inhibits leukaemia development and progression
inferred← citeshttps://doi.org/10.1038/s41419-019-1705-zopenalex-snapshot
miR-665 expression predicts poor survival and promotes tumor metastasis by targeting NR4A3 in breast cancer
inferred← citeshttps://doi.org/10.1038/s41420-022-00843-7openalex-snapshot
NR4A1 promotes LEF1 expression in the pathogenesis of papillary thyroid cancer
inferred← citeshttps://doi.org/10.1038/s41420-024-02019-xopenalex-snapshot
Nur77-IRF1 axis inhibits esophageal squamous cell carcinoma growth and improves anti-PD-1 treatment efficacy
inferred← citeshttps://doi.org/10.1038/s41423-021-00680-1openalex-snapshot
Circular RNA circZbtb20 maintains ILC3 homeostasis and function via Alkbh5-dependent m6A demethylation of Nr4a1 mRNA
inferred← citeshttps://doi.org/10.1038/s41467-017-01948-9openalex-snapshot
Dendrogenin A drives LXR to trigger lethal autophagy in cancers
inferred← citeshttps://doi.org/10.1038/s41467-018-08069-xopenalex-snapshot
Enhancer hijacking activates oncogenic transcription factor NR4A3 in acinic cell carcinomas of the salivary glands
inferred← citeshttps://doi.org/10.1038/s41467-022-35778-1openalex-snapshot
Dysregulation of PRMT5 in chronic lymphocytic leukemia promotes progression with high risk of Richter’s transformation
inferred← citeshttps://doi.org/10.1038/s41467-025-55839-5openalex-snapshot
Nr4a1 and Nr4a3 redundantly control clonal deletion and contribute to an anergy-like transcriptome in auto-reactive thymocytes to impose tolerance in mice
inferred← citeshttps://doi.org/10.1038/s41556-023-01099-8openalex-snapshot
Linking SARS-CoV-2 to the circadian clock
inferred← citeshttps://doi.org/10.1038/s41590-020-0765-7openalex-snapshot
NR4A nuclear receptors restrain B cell responses to antigen when second signals are absent or limiting
inferred← citeshttps://doi.org/10.1038/s41598-018-32972-4openalex-snapshot
Cytoplasmic location of NR4A1 in aggressive lymphomas is associated with a favourable cancer specific survival
inferred← citeshttps://doi.org/10.1038/s41598-020-59469-3openalex-snapshot
Targeting Oncogenic Super Enhancers in MYC-Dependent AML Using a Small Molecule Activator of NR4A Nuclear Receptors
inferred← citeshttps://doi.org/10.1038/s41598-020-66471-2openalex-snapshot
Signaling Inhibitors Accelerate the Conversion of mouse iPS Cells into Cancer Stem Cells in the Tumor Microenvironment
inferred← citeshttps://doi.org/10.1038/s41598-025-20348-4openalex-snapshot
NR4A1 expression aberrations contribute to radiotherapy resistance in gastric cancer
inferred← citeshttps://doi.org/10.1038/sj.leu.2405067openalex-snapshot
MEF2C is activated by multiple mechanisms in a subset of T-acute lymphoblastic leukemia cell lines
inferred← citeshttps://doi.org/10.1038/srep25944openalex-snapshot
The nuclear receptor NOR-1 regulates the small muscle protein, X-linked (SMPX) and myotube differentiation
inferred← citeshttps://doi.org/10.1038/srep31690openalex-snapshot
Epigenetic silencing of the NR4A3 tumor suppressor, by aberrant JAK/STAT signaling, predicts prognosis in gastric cancer
inferred← citeshttps://doi.org/10.1038/srep34056openalex-snapshot
NOR-1/NR4A3 regulates the cellular inhibitor of apoptosis 2 (cIAP2) in vascular cells: role in the survival response to hypoxic stress
inferred← citeshttps://doi.org/10.1042/cs20181061openalex-snapshot
A novel lncRNA NR4A1AS up-regulates orphan nuclear receptor NR4A1 expression by blocking UPF1-mediated mRNA destabilization in colorectal cancer
inferred← citeshttps://doi.org/10.1071/rd10292openalex-snapshot
Mitochondrial inhibition during preimplantation embryogenesis shifts the transcriptional profile of fetal mouse brain
inferred← citeshttps://doi.org/10.1071/rd14315openalex-snapshot
Effect of spontaneous term labour on the expression of the NR4A receptors nuclear receptor related 1 protein (Nurr1), neuron-derived clone 77 (Nur77) and neuron-derived orphan receptor 1 (NOR1) in human fetal membranes and myometrium
inferred← citeshttps://doi.org/10.1073/pnas.1821296116openalex-snapshot
The orphan nuclear receptor NR4A3 controls the differentiation of monocyte-derived dendritic cells following microbial stimulation
inferred← citeshttps://doi.org/10.1073/pnas.2002997117openalex-snapshot
Blocking PPARγ interaction facilitates Nur77 interdiction of fatty acid uptake and suppresses breast cancer progression
inferred← citeshttps://doi.org/10.1073/pnas.2007224117openalex-snapshot
Early programming of CD8 + T cell response by the orphan nuclear receptor NR4A3
inferred← citeshttps://doi.org/10.1074/jbc.ra118.002720openalex-snapshot
Nur77 variants solely comprising the amino-terminal domain activate hypoxia-inducible factor-1α and affect bone marrow homeostasis in mice and humans
inferred← citeshttps://doi.org/10.1074/jbc.ra118.003099openalex-snapshot
Transcriptional up-regulation of relaxin-3 by Nur77 attenuates β-adrenergic agonist–induced apoptosis in cardiomyocytes
inferred← citeshttps://doi.org/10.1080/10428194.2017.1387900openalex-snapshot
Reduced expression of NR4A1 activates glycolytic pathway in acute promyelocytic leukemia cells
inferred← citeshttps://doi.org/10.1080/10428194.2021.1907372openalex-snapshot
Tumor suppressors in acute myeloid leukemia
inferred← citeshttps://doi.org/10.1080/21655979.2022.2053804openalex-snapshot
Nuclear receptor 4A1 (NR4A1) silencing protects hepatocyte against hypoxia-reperfusion injury in vitro by activating liver kinase B1 (LKB1)/AMP-activated protein kinase (AMPK) signaling
inferred← citeshttps://doi.org/10.1093/carcin/bgu186openalex-snapshot
Induction of Nur77-dependent apoptotic pathway by a coumarin derivative through activation of JNK and p38 MAPK
inferred← citeshttps://doi.org/10.1093/lifemedi/lnad019openalex-snapshot
Targeting intracellular proteins with cell type-specific functions for cancer immunotherapy
inferred← citeshttps://doi.org/10.1093/molehr/gas035openalex-snapshot
Specific genes are selectively expressed between cumulus and granulosa cells from individual human pre-ovulatory follicles
inferred← citeshttps://doi.org/10.1095/biolreprod.110.083824openalex-snapshot
Nuclear Receptors in Leydig Cell Gene Expression and Function1
inferred← citeshttps://doi.org/10.1096/fj.12-209346openalex-snapshot
Class IIa HDACs repressive activities on MEF2‐depedent transcription are associated with poor prognosis of ER + breast tumors
inferred← citeshttps://doi.org/10.1096/fj.201700136rropenalex-snapshot
The nuclear receptor NOR‐1/NR4A3 regulates the multifunctional glycoprotein vitronectin in human vascular smooth muscle cells
inferred← citeshttps://doi.org/10.1096/fj.202100395ropenalex-snapshot
Atypic SUMOylation of Nor1/NR4A3 regulates neural cell viability and redox sensitivity
inferred← citeshttps://doi.org/10.1096/fj.202202029ropenalex-snapshot
Loss of NOR ‐1 represses muscle metabolism through mTORC1 ‐mediated signaling and mitochondrial gene expression in C2C12 myotubes
inferred← citeshttps://doi.org/10.1096/fj.202402775rropenalex-snapshot
Controversy and multiple roles of the solitary nucleus receptor Nur77 in disease and physiology
inferred← citeshttps://doi.org/10.1096/fj.202502730rropenalex-snapshot
Nuclear Receptor Nur77: A Key Factor and Potential Therapeutic Target in the Aging Regulatory Network
inferred← citeshttps://doi.org/10.1097/moh.0b013e3282f15fa6openalex-snapshot
Tumor necrosis factor-related apoptosis-inducing ligand and the regulation of hematopoiesis
inferred← citeshttps://doi.org/10.1097/mol.0b013e3283643eacopenalex-snapshot
NR4A nuclear receptors in immunity and atherosclerosis
inferred← citeshttps://doi.org/10.1101/2021.10.13.461056openalex-snapshot
Investigating the Role of Chromatin Remodeler FOXA1 in Ferroptotic Cell Death
inferred← citeshttps://doi.org/10.1101/2024.03.13.24304218openalex-snapshot
High throughput screening of nuclear receptors identifies NR4A1, a novel tumor suppressor with potential as a therapeutic target in gallbladder cancer
inferred← citeshttps://doi.org/10.1101/2024.05.19.594881openalex-snapshot
Transcriptional control of central T cell tolerance by NR4A family nuclear receptors
inferred← citeshttps://doi.org/10.1101/gad.16872411openalex-snapshot
Essential role for DNA-PK-mediated phosphorylation of NR4A nuclear orphan receptors in DNA double-strand break repair
inferred← citeshttps://doi.org/10.1101/gr.077578.108openalex-snapshot
In-depth characterization of the microRNA transcriptome in a leukemia progression model
inferred← citeshttps://doi.org/10.1109/fskd.2011.6019914openalex-snapshot
The study of ovarian carcinoma gene regulatory mechanism based on the shortest path algorithm and conditional probabilities
inferred← citeshttps://doi.org/10.1109/iihmsp.2010.8openalex-snapshot
Possible Disease-Link Genetic Pathways Constructed by Hierarchical Clustering and Conditional Probabilities of Ovarian Carcinoma Microarray Data
inferred← citeshttps://doi.org/10.1111/imr.13072openalex-snapshot
NR4A nuclear receptors in T and B lymphocytes: Gatekeepers of immune tolerance*
inferred← citeshttps://doi.org/10.1111/j.1365-2141.2008.07431.xopenalex-snapshot
A comparative study of bone marrow and peripheral blood CD34+ myeloblasts in acute myeloid leukaemia
inferred← citeshttps://doi.org/10.1111/j.1365-2265.2008.03349.xopenalex-snapshot
Down‐regulation of NR4A1 in follicular thyroid carcinomas is restored following lithium treatment
inferred← citeshttps://doi.org/10.1111/j.1755-148x.2011.00843.xopenalex-snapshot
Regulation of NR4A nuclear receptor expression by oncogenic BRAF in melanoma cells
inferred← citeshttps://doi.org/10.1111/jcmm.14251openalex-snapshot
ISG12a and its interaction partner NR4A1 are involved in TRAIL‐induced apoptosis in hepatoma cells
inferred← citeshttps://doi.org/10.1111/jcmm.14345openalex-snapshot
Lnc‐NA inhibits proliferation and metastasis in endometrioid endometrial carcinoma through regulation of NR4A1
inferred← citeshttps://doi.org/10.1111/jcmm.14942openalex-snapshot
Long non‐coding RNA LINC00467 drives hepatocellular carcinoma progression via inhibiting NR4A3
inferred← citeshttps://doi.org/10.1111/jcmm.16028openalex-snapshot
NR4A1 counteracts JNK activation incurred by ER stress or ROS in pancreatic β‐cells for protection
inferred← citeshttps://doi.org/10.11131/2017/101305openalex-snapshot
Conserved and Exapted Functions of Nuclear Receptors in Animal Development
inferred← citeshttps://doi.org/10.1124/pharmrev.121.000436openalex-snapshot
International Union of Basic and Clinical Pharmacology CXIII: Nuclear Receptor Superfamily—Update 2023
inferred← citeshttps://doi.org/10.1126/sciadv.adz4847openalex-snapshot
Blocking nuclear receptor Nr4a3 unlocks the senescence barrier to promote direct cardiac reprogramming
inferred← citeshttps://doi.org/10.1126/scisignal.adw5054openalex-snapshot
Dynamic feedback control of oncogenic tyrosine kinase signaling in acute leukemia
inferred← citeshttps://doi.org/10.1128/mcb.00715-14openalex-snapshot
The Orphan Nuclear Receptor Nur77 Is a Determinant of Myofiber Size and Muscle Mass in Mice
inferred← citeshttps://doi.org/10.1136/gutjnl-2011-300783openalex-snapshot
The orphan receptor TR3 suppresses intestinal tumorigenesis in mice by downregulating Wnt signalling
inferred← citeshttps://doi.org/10.1146/annurev-physiol-030212-183758openalex-snapshot
Emerging Roles of Orphan Nuclear Receptors in Cancer
inferred← citeshttps://doi.org/10.1152/ajpcell.00315.2024openalex-snapshot
Loss of glucose-stimulated β-cell Nr4a1 expression impairs insulin secretion and glucose homeostasis
inferred← citeshttps://doi.org/10.1152/ajpendo.00207.2024openalex-snapshot
Nr4a1 β-cell specific deletion impairs glucose tolerance in female mice
inferred← citeshttps://doi.org/10.1155/2021/1377989openalex-snapshot
MiR-20a-5p Negatively Regulates NR4A3 to Promote Metastasis in Bladder Cancer
inferred← citeshttps://doi.org/10.1158/0008-5472.c.6500325openalex-snapshot
Data from Role of Peroxisome Proliferator-Activated Receptor-γ and Its Coactivator DRIP205 in Cellular Responses to CDDO (RTA-401) in Acute Myelogenous Leukemia
inferred← citeshttps://doi.org/10.1158/0008-5472.can-09-1962openalex-snapshot
Role of Peroxisome Proliferator-Activated Receptor-γ and Its Coactivator DRIP205 in Cellular Responses to CDDO (RTA-401) in Acute Myelogenous Leukemia
inferred← citeshttps://doi.org/10.1158/0008-5472.can-10-1992openalex-snapshot
Inactivation of the Orphan Nuclear Receptor TR3/Nur77 Inhibits Pancreatic Cancer Cell and Tumor Growth
inferred← citeshttps://doi.org/10.1158/0008-5472.can-16-1546openalex-snapshot
PAX3-FOXO1A Expression in Rhabdomyosarcoma Is Driven by the Targetable Nuclear Receptor NR4A1
inferred← citeshttps://doi.org/10.1158/0008-5472.can-16-2320openalex-snapshot
NR4A3 Suppresses Lymphomagenesis through Induction of Proapoptotic Genes
inferred← citeshttps://doi.org/10.1158/1078-0432.ccr-16-2735openalex-snapshot
Dual Inhibition of EZH2 and EZH1 Sensitizes PRC2-Dependent Tumors to Proteasome Inhibition
inferred← citeshttps://doi.org/10.1158/1535-7163.mct-20-0474openalex-snapshot
The Histone Methyltransferase Gene G9A Is Regulated by Nuclear Receptor 4A1 in Alveolar Rhabdomyosarcoma Cells
inferred← citeshttps://doi.org/10.1158/1541-7786.mcr-08-0473openalex-snapshot
p21 Expression Is Induced by Activation of Nuclear Nerve Growth Factor–Induced Bα (Nur77) in Pancreatic Cancer Cells
inferred← citeshttps://doi.org/10.1158/1541-7786.mcr-20-0707openalex-snapshot
The Paradoxical Roles of Orphan Nuclear Receptor 4A (NR4A) in Cancer
inferred← citeshttps://doi.org/10.1159/000484162openalex-snapshot
MiR-1246 Promotes LPS-Induced Inflammatory Injury in Chondrogenic Cells ATDC5 by Targeting HNF4γ
inferred← citeshttps://doi.org/10.1161/atvbaha.110.221127openalex-snapshot
Monocyte and Macrophage Dynamics During Atherogenesis
inferred← citeshttps://doi.org/10.1161/atvbaha.116.304054openalex-snapshot
2014 Jeffrey M. Hoeg Award Lecture
inferred← citeshttps://doi.org/10.1161/circresaha.110.222083openalex-snapshot
Deficiency of the NR4A Orphan Nuclear Receptor NOR1 Decreases Monocyte Adhesion and Atherosclerosis
inferred← citeshttps://doi.org/10.1161/circresaha.111.253377openalex-snapshot
NR4A1 (Nur77) Deletion Polarizes Macrophages Toward an Inflammatory Phenotype and Increases Atherosclerosis
inferred← citeshttps://doi.org/10.1172/jci.insight.151005openalex-snapshot
NR4A family members regulate T cell tolerance to preserve immune homeostasis and suppress autoimmunity
inferred← citeshttps://doi.org/10.1177/1550762918801071openalex-snapshot
C2H2-Type Zinc Finger Proteins: Evolutionarily Old and New Partners of the Nuclear Hormone Receptors
inferred← citeshttps://doi.org/10.1182/blood-2008-08-176024openalex-snapshot
Cotreatment with BCL-2 antagonist sensitizes cutaneous T-cell lymphoma to lethal action of HDAC7-Nur77–based mechanism
inferred← citeshttps://doi.org/10.1182/blood-2009-05-218560openalex-snapshot
Gene expression classifiers for relapse-free survival and minimal residual disease improve risk classification and outcome prediction in pediatric B-precursor acute lymphoblastic leukemia
inferred← citeshttps://doi.org/10.1182/blood-2010-02-267906openalex-snapshot
Reduced NR4A gene dosage leads to mixed myelodysplastic/myeloproliferative neoplasms in mice
inferred← citeshttps://doi.org/10.1182/blood-2010-12-325555openalex-snapshot
Down-regulation of the RUNX1-target gene NR4A3 contributes to hematopoiesis deregulation in familial platelet disorder/acute myelogenous leukemia
inferred← citeshttps://doi.org/10.1182/blood-2013-08-518878openalex-snapshot
NR4A1-mediated apoptosis suppresses lymphomagenesis and is associated with a favorable cancer-specific survival in patients with aggressive B-cell lymphomas
inferred← citeshttps://doi.org/10.1182/blood-2014-06-585513openalex-snapshot
Level of RUNX1 activity is critical for leukemic predisposition but not for thrombocytopenia
inferred← citeshttps://doi.org/10.1182/blood-2015-02-626390openalex-snapshot
Hoxa cluster genes determine the proliferative activity of adult mouse hematopoietic stem and progenitor cells
inferred← citeshttps://doi.org/10.1182/blood-2017-03-770164openalex-snapshot
NR4A orphan nuclear receptor family members, NR4A2 and NR4A3, regulate neutrophil number and survival
inferred← citeshttps://doi.org/10.1182/blood-2017-07-795757openalex-snapshot
NR4A1 and NR4A3 restrict HSC proliferation via reciprocal regulation of C/EBPα and inflammatory signaling
inferred← citeshttps://doi.org/10.1182/blood.2019000468openalex-snapshot
The chromatin-binding protein Phf6 restricts the self-renewal of hematopoietic stem cells
inferred← citeshttps://doi.org/10.1182/blood.2020004834openalex-snapshot
An integrative model of pathway convergence in genetically heterogeneous blast crisis chronic myeloid leukemia
inferred← citeshttps://doi.org/10.1186/1471-2407-13-139openalex-snapshot
Dichotomous roles for the orphan nuclear receptor NURR1 in breast cancer
inferred← citeshttps://doi.org/10.1186/1476-4598-11-8openalex-snapshot
miR-10a is aberrantly overexpressed in Nucleophosmin1 mutated acute myeloid leukaemia and its suppression induces cell death
inferred← citeshttps://doi.org/10.1186/1757-2215-7-23openalex-snapshot
The MOC31PE immunotoxin reduces cell migration and induces gene expression and cell death in ovarian cancer cells
inferred← citeshttps://doi.org/10.1186/bcr2610openalex-snapshot
Dissecting the transcriptional networks underlying breast cancer: NR4A1 reduces the migration of normal and breast cancer cell lines
inferred← citeshttps://doi.org/10.1186/s11658-020-00241-wopenalex-snapshot
The nuclear receptor 4A family members: mediators in human disease and autophagy
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