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Serine and one-carbon metabolism in cancer

https://doi.org/10.1038/nrc.2016.81

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Serine Metabolism Supports the Methionine Cycle and DNA/RNA Methylation through De Novo ATP Synthesis in Cancer Cells

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NAD-dependent methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase in transformed cells is a mitochondrial enzyme

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Molecular cloning, characterization and alternative splicing of the human cytoplasmic serine hydroxymethyltransferase gene

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Carbon-13 NMR detection of folate-mediated serine and glycine synthesis in vivo in Saccharomyces cerevisiae

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Human Phosphoglycerate Dehydrogenase Produces the Oncometabolite d -2-Hydroxyglutarate

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Enzymic imbalance in serine metabolism in human colon carcinoma and rat sarcoma

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cMyc-mediated activation of serine biosynthesis pathway is critical for cancer progression under nutrient deprivation conditions

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Functional genomics reveal that the serine synthesis pathway is essential in breast cancer

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Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells

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Quantitative flux analysis reveals folate-dependent NADPH production

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SHMT2 drives glioma cell survival in ischaemia but imposes a dependence on glycine clearance

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NRF2 regulates serine biosynthesis in non–small cell lung cancer

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Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis

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The folate-coupled enzyme MTHFD2 is a nuclear protein and promotes cell proliferation

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Pyruvate kinase M2 promotes de novo serine synthesis to sustain mTORC1 activity and cell proliferation

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Human mutations in methylenetetrahydrofolate dehydrogenase 1 impair nuclear de novo thymidylate biosynthesis

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Serine Hydroxymethyltransferase Anchors de Novo Thymidylate Synthesis Pathway to Nuclear Lamina for DNA Synthesis

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Nuclear Enrichment of Folate Cofactors and Methylenetetrahydrofolate Dehydrogenase 1 (MTHFD1) Protect de Novo Thymidylate Biosynthesis during Folate Deficiency

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p53 Protein-mediated Regulation of Phosphoglycerate Dehydrogenase (PHGDH) Is Crucial for the Apoptotic Response upon Serine Starvation

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Cytoplasmic Serine Hydroxymethyltransferase Mediates Competition between Folate-dependent Deoxyribonucleotide andS-Adenosylmethionine Biosyntheses

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Regulation of Folate-mediated One-carbon Metabolism by 10-Formyltetrahydrofolate Dehydrogenase

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Cytoplasmic Serine Hydroxymethyltransferase Regulates the Metabolic Partitioning of Methylenetetrahydrofolate but Is Not Essential in Mice

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Dietary and Hormonal Regulation of Serine Synthesis in the Rat 1

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mTORC1 induces purine synthesis through control of the mitochondrial tetrahydrofolate cycle

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Compartmentalization of Mammalian Folate-Mediated One-Carbon Metabolism

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N EW P ERSPECTIVES ON F OLATE C ATABOLISM

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Tracer-derived total and folate-dependent homocysteine remethylation and synthesis rates in humans indicate that serine is the main one-carbon donor

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Shmt1 Heterozygosity Impairs Folate-Dependent Thymidylate Synthesis Capacity and Modifies Risk of Apcmin -Mediated Intestinal Cancer Risk

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Pharmacological PPARα Activation Markedly Alters Plasma Turnover of the Amino Acids Glycine, Serine and Arginine in the Rat

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Phosphoglycerate dehydrogenase is dispensable for breast tumor maintenance and growth

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Bioinformatics analysis of the serine and glycine pathway in cancer cells

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Reactive oxygen species in cancer

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Azoxymethane-Induced Colon Carcinogenesis in Mice Occurs Independently of De Novo Thymidylate Synthesis Capacity

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Mitochondrial dysfunction remodels one-carbon metabolism in human cells

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inferred← citeshttps://doi.org/10.1002/ctm2.1550openalex-snapshot

Image‐guided metabolomics and transcriptomics reveal tumour heterogeneity in luminal A and B human breast cancer beyond glucose tracer uptake

inferred← citeshttps://doi.org/10.1002/em.22626openalex-snapshot

Epigenotoxicity: Decoding the epigenetic imprints of genotoxic agents and their implications for regulatory genetic toxicology

inferred← citeshttps://doi.org/10.1002/iid3.1268openalex-snapshot

Macrophage polarization and metabolic reprogramming in abdominal aortic aneurysm

inferred← citeshttps://doi.org/10.1002/ijc.33423openalex-snapshot

Inhibiting phosphoglycerate dehydrogenase counteracts chemotherapeutic efficacy against MYCN ‐amplified neuroblastoma

inferred← citeshttps://doi.org/10.1002/iub.2367openalex-snapshot

The malate–aspartate shuttle (Borst cycle): How it started and developed into a major metabolic pathway

inferred← citeshttps://doi.org/10.1002/mc.22849openalex-snapshot

EWS‐FLI1 reprograms the metabolism of Ewing sarcoma cells via positive regulation of glutamine import and serine‐glycine biosynthesis

inferred← citeshttps://doi.org/10.1002/mc.23379openalex-snapshot

Metabolic response to radiation therapy in cancer

inferred← citeshttps://doi.org/10.1002/mc.23881openalex-snapshot

Glutamine, Serine and Glycine at Increasing Concentrations Regulate Cisplatin Sensitivity in Gastric Cancer by Posttranslational Modifications of KDM4A

inferred← citeshttps://doi.org/10.1002/mef2.12openalex-snapshot

Mechanism and application of nonessential amino acid deprivation associated with tumor therapy

inferred← citeshttps://doi.org/10.1002/mog2.70062openalex-snapshot

The Role of One‐Carbon Metabolism in Cancer and Its Therapeutic Significance

inferred← citeshttps://doi.org/10.1002/mrm.30198openalex-snapshot

Deuterium MRI of serine metabolism in mouse models of glioblastoma

inferred← citeshttps://doi.org/10.1002/path.5085openalex-snapshot

Menin regulates the serine biosynthetic pathway in Ewing sarcoma

inferred← citeshttps://doi.org/10.1002/slct.202402522openalex-snapshot

Computational Design, Chemical Synthesis, and Bioevaluation of Pyrimidinyl‐Indoles for Targeting Breast Cancer Cells

inferred← citeshttps://doi.org/10.1002/smll.202406942openalex-snapshot

Cuproptosis and Serine Metabolism Blockade Triggered by Copper‐Based Prussian Blue Nanomedicine for Enhanced Tumor Therapy

inferred← citeshttps://doi.org/10.1002/smll.202504631openalex-snapshot

Precise Targeting One‐Carbon Metabolism for Potent Cancer Therapy and Metastasis Suppression

inferred← citeshttps://doi.org/10.1002/viw.20240114openalex-snapshot

Modeling fire‐related smoke inhalation injury using the human lung‐on‐a‐chip and organoid platform: Pathogenesis insights and therapeutic evaluation

inferred← citeshttps://doi.org/10.1002/wsbm.1397openalex-snapshot

Metabolic interactions in cancer: cellular metabolism at the interface between the microenvironment, the cancer cell phenotype and the epigenetic landscape

inferred← citeshttps://doi.org/10.1002/yea.3840openalex-snapshot

Serine metabolism contributes to cell survival by regulating extracellular pH and providing an energy source in Saccharomyces cerevisiae

inferred← citeshttps://doi.org/10.1007/124_2023_73openalex-snapshot

Serine Metabolic Networks in Plants

inferred← citeshttps://doi.org/10.1007/978-3-030-34025-4_6openalex-snapshot

Metabolic Plasticity of Tumor Cells: How They Do Adapt to Food Deprivation

inferred← citeshttps://doi.org/10.1007/978-3-030-51652-9_18openalex-snapshot

Metabolomics of Glioma

inferred← citeshttps://doi.org/10.1007/978-3-030-54462-1_1openalex-snapshot

One-Carbon Metabolism and Development of the Conceptus During Pregnancy: Lessons from Studies with Sheep and Pigs

inferred← citeshttps://doi.org/10.1007/978-3-030-65768-0_16openalex-snapshot

Diabetes and Cancer: The Epidemiological and Metabolic Associations

inferred← citeshttps://doi.org/10.1007/978-3-030-73856-3_1openalex-snapshot

Metabolic Contributions to Anoikis-Resistance in Metastatic Dissemination

inferred← citeshttps://doi.org/10.1007/978-3-030-80962-1_402-1openalex-snapshot

Metabolic Pathways in Pediatric Cancers

inferred← citeshttps://doi.org/10.1007/978-3-031-63657-8_28openalex-snapshot

New Insights into the Link Between Melanoma and Obesity

inferred← citeshttps://doi.org/10.1007/978-3-032-00771-1_402openalex-snapshot

Metabolic Pathways in Pediatric Cancers

inferred← citeshttps://doi.org/10.1007/978-3-032-26629-3_10openalex-snapshot

Enzyme Assemblies in Nucleotide Metabolism: Structure, Regulation, and Disease Implications

inferred← citeshttps://doi.org/10.1007/978-3-319-59242-8_2openalex-snapshot

Biological and Clinical Evidence for Metabolic Dormancy in Solid Tumors Post Therapy

inferred← citeshttps://doi.org/10.1007/978-3-319-61401-4_2openalex-snapshot

A Topical Report on the Design Principles of Metabolism

inferred← citeshttps://doi.org/10.1007/978-981-15-1991-8_1openalex-snapshot

Cancer Cell Metabolism: Solid Tumor Versus Nonsolid Tumor

inferred← citeshttps://doi.org/10.1007/978-981-19-8930-8_1openalex-snapshot

Cancer Biology and Microenvironment

inferred← citeshttps://doi.org/10.1007/978-981-96-7336-0_9openalex-snapshot

Targeting Metabolic Reprogramming: A New Frontier in Cancer Therapy

inferred← citeshttps://doi.org/10.1007/978-981-97-9877-3_10openalex-snapshot

Anabolism and Catabolism of Coenzyme II

inferred← citeshttps://doi.org/10.1007/978-981-97-9877-3_8openalex-snapshot

Sources and Cellular Distribution of Coenzyme II

inferred← citeshttps://doi.org/10.1007/s00011-023-01815-yopenalex-snapshot

Serine metabolism in macrophage polarization

inferred← citeshttps://doi.org/10.1007/s00018-023-04902-9openalex-snapshot

Breast cancers as ecosystems: a metabolic perspective

inferred← citeshttps://doi.org/10.1007/s00216-026-06623-xopenalex-snapshot

Impact of blood contamination on hydrophilic metabolomics in human meningioma tissue

inferred← citeshttps://doi.org/10.1007/s00244-020-00757-4openalex-snapshot

The Preliminary Study on the Association Between PAHs and Air Pollutants and Microbiota Diversity

inferred← citeshttps://doi.org/10.1007/s00284-024-03801-xopenalex-snapshot

Roles of Critical Amino Acids Metabolism in The Interactions Between Intracellular Bacterial Infection and Macrophage Function

inferred← citeshttps://doi.org/10.1007/s00439-017-1803-xopenalex-snapshot

The role of RNA alternative splicing in regulating cancer metabolism

inferred← citeshttps://doi.org/10.1007/s00726-022-03212-xopenalex-snapshot

The ovine conceptus utilizes extracellular serine, glucose, and fructose to generate formate via the one carbon metabolism pathway

inferred← citeshttps://doi.org/10.1007/s00726-023-03316-yopenalex-snapshot

Participation of protein metabolism in cancer progression and its potential targeting for the management of cancer

inferred← citeshttps://doi.org/10.1007/s10123-021-00195-9openalex-snapshot

Morphological and transcriptomic analysis of attenuated and virulent strains of Phytophthora infestans

inferred← citeshttps://doi.org/10.1007/s10123-023-00457-8openalex-snapshot

Imbalanced metabolism induced NH4+ accumulation and its effect on the central metabolism of Methylomonas sp. ZR1

inferred← citeshttps://doi.org/10.1007/s10549-024-07462-zopenalex-snapshot

Phosphoenolpyruvate carboxykinase-2 (PCK2) is a therapeutic target in triple-negative breast cancer

inferred← citeshttps://doi.org/10.1007/s10555-025-10308-9openalex-snapshot

One-carbon metabolism in cancer: moonlighting functions of metabolic enzymes and anti-tumor therapy

inferred← citeshttps://doi.org/10.1007/s10555-026-10355-wopenalex-snapshot

MYCN-driven metabolic remodelling of the tumour microenvironment in neuroblastoma: implications for stromal biology and CAF heterogeneity

inferred← citeshttps://doi.org/10.1007/s10571-026-01696-9openalex-snapshot

D-serine: A Multitalented Neuromodulator in Brain Function, Systemic Homeostasis, and Disease

inferred← citeshttps://doi.org/10.1007/s10637-025-01581-0openalex-snapshot

Comparative analysis of the effects of PSPH and PHGDH inhibitors on tumor cell proliferation

inferred← citeshttps://doi.org/10.1007/s10787-018-00560-7openalex-snapshot

Anti-inflammatory mechanisms of cannabinoids: an immunometabolic perspective

inferred← citeshttps://doi.org/10.1007/s11010-018-3391-zopenalex-snapshot

The effects of l-cysteine and N-acetyl-l-cysteine on homocysteine metabolism and haemostatic markers, and on cardiac and aortic histology in subchronically methionine-treated Wistar male rats

inferred← citeshttps://doi.org/10.1007/s11033-020-05775-yopenalex-snapshot

Detection and characterisation of novel alternative splicing variants of the mitochondrial folate enzyme MTHFD2

inferred← citeshttps://doi.org/10.1007/s11064-019-02934-xopenalex-snapshot

Amino Acid Transporters and Exchangers from the SLC1A Family: Structure, Mechanism and Roles in Physiology and Cancer

inferred← citeshttps://doi.org/10.1007/s11306-018-1448-3openalex-snapshot

Targeted metabolomic profiling of low and high grade serous epithelial ovarian cancer tissues: a pilot study

inferred← citeshttps://doi.org/10.1007/s11306-018-1452-7openalex-snapshot

Insights into gemcitabine resistance and the potential for therapeutic monitoring

inferred← citeshttps://doi.org/10.1007/s11306-021-01852-wopenalex-snapshot

Metabonomics study of the effects of single copy mutant KRAS in the presence or absence of WT allele using human HCT116 isogenic cell lines

inferred← citeshttps://doi.org/10.1007/s11306-024-02096-0openalex-snapshot

Identification of glucose-independent and reversible metabolic pathways associated with anti-proliferative effect of metformin in liver cancer cells

inferred← citeshttps://doi.org/10.1007/s11357-024-01444-1openalex-snapshot

Serine metabolism in aging and age-related diseases

inferred← citeshttps://doi.org/10.1007/s11427-024-2761-yopenalex-snapshot

Multi-omics analysis revealed the addiction to glutamine and susceptibility to de novo lipogenesis of endometrial neoplasm

inferred← citeshttps://doi.org/10.1007/s11427-024-2938-3openalex-snapshot

PEX5 deficiency enhances radiosensitivity via MGST1-GSH detoxifying function and promotes ferroptosis in liver cancer

inferred← citeshttps://doi.org/10.1007/s11914-022-00721-2openalex-snapshot

Bioenergetic Metabolism In Osteoblast Differentiation

inferred← citeshttps://doi.org/10.1007/s12011-024-04492-yopenalex-snapshot

Activation of the De Novo Serine Synthesis Pathway and Disruption of Insulin Signaling Induced by Supplemental SeMet in Vitro

inferred← citeshttps://doi.org/10.1007/s12013-026-02050-yopenalex-snapshot

Amino Acids as Targets for Immunotherapy against Solid Tumors

inferred← citeshttps://doi.org/10.1007/s12017-019-08553-7openalex-snapshot

Sideroflexin 3 is a Mitochondrial Protein Enriched in Neurons

inferred← citeshttps://doi.org/10.1007/s12026-024-09483-8openalex-snapshot

The immunosuppressive landscape in tumor microenvironment

inferred← citeshttps://doi.org/10.1007/s12035-017-0840-8openalex-snapshot

Disruption of De Novo Serine Synthesis in Müller Cells Induced Mitochondrial Dysfunction and Aggravated Oxidative Damage

inferred← citeshttps://doi.org/10.1007/s12094-025-03990-2openalex-snapshot

Recent advances in novel targeting mechanisms for colorectal cancer

inferred← citeshttps://doi.org/10.1007/s12257-025-00247-1openalex-snapshot

The serine synthesis pathway is indispensable for glioblastoma growth and malignancy

inferred← citeshttps://doi.org/10.1007/s12551-020-00659-8openalex-snapshot

Metabolic features of cancer cells in NRF2 addiction status

inferred← citeshttps://doi.org/10.1007/s12640-017-9814-xopenalex-snapshot

L-Serine: a Naturally-Occurring Amino Acid with Therapeutic Potential

inferred← citeshttps://doi.org/10.1007/s12672-024-01013-0openalex-snapshot

Preclinical efficacy of CBR-5884 against epithelial ovarian cancer cells by targeting the serine synthesis pathway

inferred← citeshttps://doi.org/10.1007/s12672-025-01949-xopenalex-snapshot

Deciphering the metabolic landscape of colorectal cancer through the lens of AhR-mediated intestinal inflammation

inferred← citeshttps://doi.org/10.1007/s12672-025-03845-wopenalex-snapshot

Deciphering the causal effects of plasma metabolomics and lipids on breast cancer risk: a Mendelian randomization analysis

inferred← citeshttps://doi.org/10.1007/s12672-025-04282-5openalex-snapshot

Exploring metabolic dynamics of cancer metastasis through in vitro models

inferred← citeshttps://doi.org/10.1007/s13238-021-00846-7openalex-snapshot

Metabolic reprogramming and epigenetic modifications on the path to cancer

inferred← citeshttps://doi.org/10.1007/s13402-018-0383-7openalex-snapshot

Role of PKM2 in directing the metabolic fate of glucose in cancer: a potential therapeutic target

inferred← citeshttps://doi.org/10.1007/s13402-021-00599-9openalex-snapshot

3-Phosphoglycerate dehydrogenase: a potential target for cancer treatment

inferred← citeshttps://doi.org/10.1007/s40142-025-00227-0openalex-snapshot

Insights into the Multifaceted Roles and Pleiotropic Functions of ALDH1L2 with Implications in Gastrointestinal Diseases and Cancer

inferred← citeshttps://doi.org/10.1016/b978-0-12-819621-2.00005-xopenalex-snapshot

Mitochondrial dysfunction in kidney diseases

inferred← citeshttps://doi.org/10.1016/b978-0-12-824356-5.00002-3openalex-snapshot

Cancer metabolism regulation by phytonutrients

inferred← citeshttps://doi.org/10.1016/b978-0-323-47674-4.00009-8openalex-snapshot

Cancer Metabolism

inferred← citeshttps://doi.org/10.1016/b978-0-323-90256-4.00015-1openalex-snapshot

Mitochondrion at the crossroads between nutrients and the epigenome

inferred← citeshttps://doi.org/10.1016/b978-0-323-91704-9.00014-8openalex-snapshot

Exploring glycolytic adaptations in cancer cells

inferred← citeshttps://doi.org/10.1016/b978-0-443-14064-8.00028-xopenalex-snapshot

Dietary alterations to induce antitumor immunity

inferred← citeshttps://doi.org/10.1016/b978-0-443-19104-6.00009-7openalex-snapshot

Metabolic control of microglia in health and disease

inferred← citeshttps://doi.org/10.1016/b978-0-443-43870-7.00010-2openalex-snapshot

Mitochondrial targeting in cancer therapeutics

inferred← citeshttps://doi.org/10.1016/bs.acc.2018.02.002openalex-snapshot

Metabolomics and Lipidomics of Ischemic Stroke

inferred← citeshttps://doi.org/10.1016/bs.acr.2021.03.009openalex-snapshot

Reductive stress in cancer

inferred← citeshttps://doi.org/10.1016/bs.acr.2021.06.002openalex-snapshot

Metabolic control of cancer progression as novel targets for therapy

inferred← citeshttps://doi.org/10.1016/bs.apcsb.2020.09.001openalex-snapshot

Cancer bioenergetics as emerging holistic cancer theory: the role of metabolic fluxes and transport proteins involved in metabolic pathways in the pathogenesis of malignancies. State-of-the-art and future prospects

inferred← citeshttps://doi.org/10.1016/bs.ircmb.2019.07.007openalex-snapshot

Drugging cancer metabolism: Expectations vs. reality

inferred← citeshttps://doi.org/10.1016/bs.ircmb.2022.03.001openalex-snapshot

Combination strategies to target metabolic flexibility in cancer

inferred← citeshttps://doi.org/10.1016/j.abb.2020.108659openalex-snapshot

Metabolic interventions: A new insight into the cancer immunotherapy

inferred← citeshttps://doi.org/10.1016/j.abb.2024.110104openalex-snapshot

Knockdown of ERN1 disturbs the expression of phosphoserine aminotransferase 1 and related genes in glioblastoma cells

inferred← citeshttps://doi.org/10.1016/j.advnut.2023.05.007openalex-snapshot

Serine Metabolic Reprogramming in Tumorigenesis, Tumor Immunity, and Clinical Treatment

inferred← citeshttps://doi.org/10.1016/j.ajog.2020.11.005openalex-snapshot

Placental energy metabolism in health and disease—significance of development and implications for preeclampsia

inferred← citeshttps://doi.org/10.1016/j.ajpath.2024.01.021openalex-snapshot

Serine Supports Epithelial and Immune Cell Function in Colitis

inferred← citeshttps://doi.org/10.1016/j.ajpath.2025.04.003openalex-snapshot

Transcription Factor YY2 Inhibits Tumor Cell Glutamine Catabolism by Regulating GLS1 RNA Splicing Isoform GAC

inferred← citeshttps://doi.org/10.1016/j.annonc.2020.02.002openalex-snapshot

Epigenetic modulations and lineage plasticity in advanced prostate cancer

inferred← citeshttps://doi.org/10.1016/j.apsb.2021.06.008openalex-snapshot

Identification of a novel PHGDH covalent inhibitor by chemical proteomics and phenotypic profiling

inferred← citeshttps://doi.org/10.1016/j.aquaculture.2021.737517openalex-snapshot

Evaluation of Methanotroph (Methylococcus capsulatus, Bath) bacteria meal on body composition, lipid metabolism, protein synthesis and muscle metabolites of Pacific white shrimp (Litopenaeus vannamei)

inferred← citeshttps://doi.org/10.1016/j.aquaculture.2024.741713openalex-snapshot

An integrated metabolomics and proteomics analysis reveals copper‑zinc alloy surface contact-mediated metabolic disruption, lipid peroxidation, and osmotic imbalance of Cryptocaryon irritans tomonts

inferred← citeshttps://doi.org/10.1016/j.aquaculture.2025.743117openalex-snapshot

Integrated proteomic and metabolomic analyses reveal mechanisms underlying soy protein hydrolysate-induced metabolic reprogramming and enhanced growth in turbot (Scophthalmus maximus)

inferred← citeshttps://doi.org/10.1016/j.arr.2024.102603openalex-snapshot

The mitochondrial integrated stress response: A novel approach to anti-aging and pro-longevity

inferred← citeshttps://doi.org/10.1016/j.arr.2025.102988openalex-snapshot

Measuring biological age: Insights from omics studies

inferred← citeshttps://doi.org/10.1016/j.aspetd.2026.100029openalex-snapshot

Emerging concepts on one-carbon metabolism as a unique and actionable vulnerability in cancer

inferred← citeshttps://doi.org/10.1016/j.bbadis.2020.165841openalex-snapshot

Reprogramming of serine, glycine and one-carbon metabolism in cancer

inferred← citeshttps://doi.org/10.1016/j.bbadis.2024.167034openalex-snapshot

Effect of l-serine and magnesium ions on the functional properties of human phosphoserine phosphatase and its pathogenetic variants

inferred← citeshttps://doi.org/10.1016/j.bbamcr.2022.119359openalex-snapshot

Control of cell metabolism by the epidermal growth factor receptor

inferred← citeshttps://doi.org/10.1016/j.bbcan.2020.188442openalex-snapshot

Role of tyrosine phosphorylation in modulating cancer cell metabolism

inferred← citeshttps://doi.org/10.1016/j.bbcan.2023.188893openalex-snapshot

The role of amino acid metabolism alterations in pancreatic cancer: From mechanism to application

inferred← citeshttps://doi.org/10.1016/j.bbcan.2023.188952openalex-snapshot

PI3K signaling-regulated metabolic reprogramming: From mechanism to application

inferred← citeshttps://doi.org/10.1016/j.bbcan.2026.189593openalex-snapshot

Mitochondrial respiration supports cancer growth independent of OXPHOS

inferred← citeshttps://doi.org/10.1016/j.bbrc.2021.11.001openalex-snapshot

A novel oral inhibitor for one-carbon metabolism and checkpoint kinase 1 inhibitor as a rational combination treatment for breast cancer

inferred← citeshttps://doi.org/10.1016/j.bbrc.2024.150306openalex-snapshot

Structural identification and comprehension of human ALDH1L1-Gossypol complex

inferred← citeshttps://doi.org/10.1016/j.bbrc.2024.150461openalex-snapshot

Chlamydia trachomatis L2 434/Bu readily activates glycolysis under hypoxia for efficient metabolism

inferred← citeshttps://doi.org/10.1016/j.bbrep.2023.101528openalex-snapshot

Emerging roles of cytosolic phosphoenolpyruvate kinase 1 (PCK1) in cancer

inferred← citeshttps://doi.org/10.1016/j.bbrep.2026.102544openalex-snapshot

One-carbon metabolism and cardiovascular disease: Molecular mechanisms, genetic influences, and epigenetic regulation

inferred← citeshttps://doi.org/10.1016/j.bcp.2021.114597openalex-snapshot

Pharmacological inhibition of GLUT1 as a new immunotherapeutic approach after myocardial infarction

inferred← citeshttps://doi.org/10.1016/j.bcp.2023.115697openalex-snapshot

Surviving the hunger games: Metabolic reprogramming in medulloblastoma

inferred← citeshttps://doi.org/10.1016/j.bcp.2026.118376openalex-snapshot

PHGDH: metabolic enzyme or signaling hub? From broad-spectrum inhibition toward context-adapted therapeutic targeting

inferred← citeshttps://doi.org/10.1016/j.bej.2020.107624openalex-snapshot

Identifying metabolic features and engineering targets for productivity improvement in CHO cells by integrated transcriptomics and genome-scale metabolic model

inferred← citeshttps://doi.org/10.1016/j.bioorg.2024.107330openalex-snapshot

Identification of benzo[b]thiophene-1,1-dioxide derivatives as novel PHGDH covalent inhibitors

inferred← citeshttps://doi.org/10.1016/j.biopha.2020.110872openalex-snapshot

LKB1 and cancer: The dual role of metabolic regulation

inferred← citeshttps://doi.org/10.1016/j.biopha.2023.115006openalex-snapshot

YY2/PHGDH axis suppresses tumorigenesis by inhibiting tumor cell de novo serine biosynthesis

inferred← citeshttps://doi.org/10.1016/j.biopha.2025.118458openalex-snapshot

The significance of dysregulated serine metabolism in depression

inferred← citeshttps://doi.org/10.1016/j.biotechadv.2018.01.007openalex-snapshot

Targeting of stress response pathways in the prevention and treatment of cancer

inferred← citeshttps://doi.org/10.1016/j.biotechadv.2021.107887openalex-snapshot

Feedback regulation and coordination of the main metabolism for bacterial growth and metabolic engineering for amino acid fermentation

inferred← citeshttps://doi.org/10.1016/j.bj.2020.08.001openalex-snapshot

G6PD: A hub for metabolic reprogramming and redox signaling in cancer

inferred← citeshttps://doi.org/10.1016/j.cancergen.2019.05.005openalex-snapshot

Association of transcriptional levels of folate-mediated one-carbon metabolism-related genes in cancer cell lines with drug treatment response

inferred← citeshttps://doi.org/10.1016/j.canlet.2019.09.010openalex-snapshot

NRF2 SUMOylation promotes de novo serine synthesis and maintains HCC tumorigenesis

inferred← citeshttps://doi.org/10.1016/j.canlet.2019.11.013openalex-snapshot

Dysregulation of de novo nucleotide biosynthetic pathway enzymes in cancer and targeting opportunities

inferred← citeshttps://doi.org/10.1016/j.canlet.2020.02.040openalex-snapshot

Drosha-independent miR-6778–5p strengthens gastric cancer stem cell stemness via regulation of cytosolic one-carbon folate metabolism

inferred← citeshttps://doi.org/10.1016/j.canlet.2022.215903openalex-snapshot

Folate enzyme MTHFD2 links one-carbon metabolism to unfolded protein response in glioblastoma

inferred← citeshttps://doi.org/10.1016/j.canlet.2023.216304openalex-snapshot

Anaplastic Thyroid Cancer Cells Upregulate Mitochondrial One-Carbon Metabolism To Meet Purine Demand, Eliciting A Critical Targetable Vulnerability

inferred← citeshttps://doi.org/10.1016/j.carbpol.2023.120601openalex-snapshot

Structural characterization and anti-osteoporosis effects of polysaccharide purified from Eucommia ulmoides Oliver cortex based on its modulation on bone metabolism

inferred← citeshttps://doi.org/10.1016/j.cbd.2024.101259openalex-snapshot

The energy metabolism and transcriptomic responses of the Manila clam (Ruditapes philippinarum) under the low-temperature stress

inferred← citeshttps://doi.org/10.1016/j.ccell.2019.01.018openalex-snapshot

Increased Serine and One-Carbon Pathway Metabolism by PKCλ/ι Deficiency Promotes Neuroendocrine Prostate Cancer

inferred← citeshttps://doi.org/10.1016/j.ccell.2020.04.005openalex-snapshot

Dietary Approaches to Cancer Therapy

inferred← citeshttps://doi.org/10.1016/j.ccell.2020.06.001openalex-snapshot

Oxidative Stress in Cancer

inferred← citeshttps://doi.org/10.1016/j.ccr.2023.215540openalex-snapshot

Advanced nanomaterials for enhanced immunotherapy via metabolic regulation

inferred← citeshttps://doi.org/10.1016/j.cej.2026.179744openalex-snapshot

Micro-crosslinked hyaluronic acid hydrogel ameliorates skin aging through NFIX-mediated collagen regeneration

inferred← citeshttps://doi.org/10.1016/j.cell.2018.09.041openalex-snapshot

Mitochondrial One-Carbon Pathway Supports Cytosolic Folate Integrity in Cancer Cells

inferred← citeshttps://doi.org/10.1016/j.cell.2020.10.016openalex-snapshot

Neurons Release Serine to Support mRNA Translation in Pancreatic Cancer

inferred← citeshttps://doi.org/10.1016/j.cellsig.2023.110736openalex-snapshot

PHGDH promotes esophageal squamous cell carcinoma progression via Wnt/β-catenin pathway

inferred← citeshttps://doi.org/10.1016/j.cellsig.2026.112931openalex-snapshot

FPGS drives breast cancer proliferation via CDK9-mediated mitophagy through the mTOR signaling pathway

inferred← citeshttps://doi.org/10.1016/j.celrep.2017.04.061openalex-snapshot

Thymidine Catabolism as a Metabolic Strategy for Cancer Survival

inferred← citeshttps://doi.org/10.1016/j.celrep.2017.05.067openalex-snapshot

PHGDH Defines a Metabolic Subtype in Lung Adenocarcinomas with Poor Prognosis

inferred← citeshttps://doi.org/10.1016/j.celrep.2017.10.072openalex-snapshot

Partitioning of One-Carbon Units in Folate and Methionine Metabolism Is Essential for Neural Tube Closure

inferred← citeshttps://doi.org/10.1016/j.celrep.2018.03.017openalex-snapshot

Serine Availability Influences Mitochondrial Dynamics and Function through Lipid Metabolism

inferred← citeshttps://doi.org/10.1016/j.celrep.2020.03.005openalex-snapshot

c-Src Promotes Tumorigenesis and Tumor Progression by Activating PFKFB3

inferred← citeshttps://doi.org/10.1016/j.celrep.2021.109706openalex-snapshot

ATF3 promotes the serine synthesis pathway and tumor growth under dietary serine restriction

inferred← citeshttps://doi.org/10.1016/j.celrep.2021.110037openalex-snapshot

Glucose metabolism and pyruvate carboxylase enhance glutathione synthesis and restrict oxidative stress in pancreatic islets

inferred← citeshttps://doi.org/10.1016/j.celrep.2022.111093openalex-snapshot

Mucolytic bacteria license pathobionts to acquire host-derived nutrients during dietary nutrient restriction

inferred← citeshttps://doi.org/10.1016/j.celrep.2022.111233openalex-snapshot

SHMT2-mediated mitochondrial serine metabolism drives 5-FU resistance by fueling nucleotide biosynthesis

inferred← citeshttps://doi.org/10.1016/j.celrep.2023.112411openalex-snapshot

ZFP36-mediated mRNA decay regulates metabolism

inferred← citeshttps://doi.org/10.1016/j.celrep.2023.112562openalex-snapshot

ALDH1L2 regulation of formate, formyl-methionine, and ROS controls cancer cell migration and metastasis

inferred← citeshttps://doi.org/10.1016/j.celrep.2023.112615openalex-snapshot

Pancreatic islet protection at the expense of secretory function involves serine-linked mitochondrial one-carbon metabolism

inferred← citeshttps://doi.org/10.1016/j.celrep.2023.113034openalex-snapshot

Formate promotes invasion and metastasis in reliance on lipid metabolism

inferred← citeshttps://doi.org/10.1016/j.celrep.2025.115661openalex-snapshot

The m C methyltransferase NSUN2 promotes progression of acute myeloid leukemia by regulating serine metabolism

inferred← citeshttps://doi.org/10.1016/j.chembiol.2020.03.014openalex-snapshot

Achieving Life through Death: Redox Biology of Lipid Peroxidation in Ferroptosis

inferred← citeshttps://doi.org/10.1016/j.cmet.2018.01.008openalex-snapshot

Metabolism in Pluripotent Stem Cells and Early Mammalian Development

inferred← citeshttps://doi.org/10.1016/j.cmet.2018.02.024openalex-snapshot

Increased Tumor Glycolysis Characterizes Immune Resistance to Adoptive T Cell Therapy

inferred← citeshttps://doi.org/10.1016/j.cmet.2019.01.014openalex-snapshot

Serine Metabolism Supports Macrophage IL-1β Production

inferred← citeshttps://doi.org/10.1016/j.cmet.2019.06.003openalex-snapshot

Epstein-Barr-Virus-Induced One-Carbon Metabolism Drives B Cell Transformation

inferred← citeshttps://doi.org/10.1016/j.cmet.2019.11.012openalex-snapshot

Activation of Oxidative Stress Response in Cancer Generates a Druggable Dependency on Exogenous Non-essential Amino Acids

inferred← citeshttps://doi.org/10.1016/j.cmet.2020.01.006openalex-snapshot

Methionine Metabolism Shapes T Helper Cell Responses through Regulation of Epigenetic Reprogramming

inferred← citeshttps://doi.org/10.1016/j.cmet.2021.03.006openalex-snapshot

Serine metabolism antagonizes antiviral innate immunity by preventing ATP6V0d2-mediated YAP lysosomal degradation

inferred← citeshttps://doi.org/10.1016/j.cmet.2023.01.010openalex-snapshot

PHGDH-mediated endothelial metabolism drives glioblastoma resistance to chimeric antigen receptor T cell immunotherapy

inferred← citeshttps://doi.org/10.1016/j.cmet.2023.12.001openalex-snapshot

Glycine homeostasis requires reverse SHMT flux

inferred← citeshttps://doi.org/10.1016/j.cmet.2024.07.021openalex-snapshot

Serine and glycine physiology reversibly modulate retinal and peripheral nerve function

inferred← citeshttps://doi.org/10.1016/j.coisb.2017.05.007openalex-snapshot

Anticancer drug discovery through genome-scale metabolic modeling

inferred← citeshttps://doi.org/10.1016/j.copbio.2020.12.001openalex-snapshot

The emerging role of one-carbon metabolism in T cells

inferred← citeshttps://doi.org/10.1016/j.cophys.2017.11.006openalex-snapshot

More than a powerplant: the influence of mitochondrial transfer on the epigenome

inferred← citeshttps://doi.org/10.1016/j.critrevonc.2025.104950openalex-snapshot

Proteomics signatures of human breast cancer: A systematic review

inferred← citeshttps://doi.org/10.1016/j.critrevonc.2025.105001openalex-snapshot

Tumor microenvironment and metabolic reprogramming: Unraveling the complex interplay in gastrointestinal tumor liver metastasis

inferred← citeshttps://doi.org/10.1016/j.crmeth.2021.100016openalex-snapshot

Global Analysis of Protein Arginine Methylation

inferred← citeshttps://doi.org/10.1016/j.csbj.2021.05.019openalex-snapshot

Modelling of SHMT1 riboregulation predicts dynamic changes of serine and glycine levels across cellular compartments

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