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Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer

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Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/0470862637.ch19openalex-snapshot

Molecular and Cellular Basis for the Anti‐Proliferative Effects of the HDAC Inhibitor LAQ824

inferredcites →https://doi.org/10.1002/ajh.2830460409openalex-snapshot

Analysis of p53 gene mutations in acute myeloid leukemia

inferredcites →https://doi.org/10.1002/bies.20210openalex-snapshot

Regulatory cross-talk between lysine acetylation and ubiquitination: role in the control of protein stability

inferredcites →https://doi.org/10.1002/cncr.21132openalex-snapshot

Increase in platelet count in older, poor‐risk patients with acute myeloid leukemia or myelodysplastic syndrome treated with valproic acid and all‐trans retinoic acid

inferredcites →https://doi.org/10.1002/cyto.a.20151openalex-snapshot

New method to detect histone acetylation levels by flow cytometry

inferredcites →https://doi.org/10.1002/ijc.20154openalex-snapshot

Expression of the metastasis‐associated MTA1 protein and its relationship to deacetylation of the histone H4 in esophageal squamous cell carcinomas

inferredcites →https://doi.org/10.1002/med.20024openalex-snapshot

Histone deacetylation in epigenetics: An attractive target for anticancer therapy

inferredcites →https://doi.org/10.1006/scdb.1999.0303openalex-snapshot

Retinoid receptors in health and disease: co-regulators and the chromatin connection

inferredcites →https://doi.org/10.1016/j.bbaexp.2003.11.015openalex-snapshot

The activities of eukaryotic replication origins in chromatin

inferredcites →https://doi.org/10.1016/j.canlet.2004.08.024openalex-snapshot

Histone metabolic pathways and chromatin assembly factors as proliferation markers

inferredcites →https://doi.org/10.1016/j.cell.2004.10.024openalex-snapshot

Histone Deacetylase 4 Controls Chondrocyte Hypertrophy during Skeletogenesis

inferredcites →https://doi.org/10.1016/j.cell.2005.06.013openalex-snapshot

Complicated Tails: Histone Modifications and the DNA Damage Response

inferredcites →https://doi.org/10.1016/j.gde.2003.11.007openalex-snapshot

Therapeutic implications of cancer stem cells

inferredcites →https://doi.org/10.1016/j.jmb.2004.02.006openalex-snapshot

Molecular Evolution of the Histone Deacetylase Family: Functional Implications of Phylogenetic Analysis

inferredcites →https://doi.org/10.1016/j.molcel.2005.04.021openalex-snapshot

HDAC6 Regulates Hsp90 Acetylation and Chaperone-Dependent Activation of Glucocorticoid Receptor

inferredcites →https://doi.org/10.1016/j.semcdb.2003.12.001openalex-snapshot

SUMO and transcriptional regulation

inferredcites →https://doi.org/10.1016/j.str.2004.04.012openalex-snapshot

Structural Snapshots of Human HDAC8 Provide Insights into the Class I Histone Deacetylases

inferredcites →https://doi.org/10.1016/s0076-6879(03)76013-3openalex-snapshot

Histone Deacetylase Inhibitors: Assays to Assess Effectiveness In Vitro and In Vivo

inferredcites →https://doi.org/10.1016/s0092-8674(02)00861-9openalex-snapshot

Class II Histone Deacetylases Act as Signal-Responsive Repressors of Cardiac Hypertrophy

inferredcites →https://doi.org/10.1016/s0092-8674(02)01080-2openalex-snapshot

Cellular Memory and the Histone Code

inferredcites →https://doi.org/10.1016/s0092-8674(02)01085-1openalex-snapshot

Regulation and Destabilization of HIF-1α by ARD1-Mediated Acetylation

inferredcites →https://doi.org/10.1016/s0092-8674(03)00939-5openalex-snapshot

The Deacetylase HDAC6 Regulates Aggresome Formation and Cell Viability in Response to Misfolded Protein Stress

inferredcites →https://doi.org/10.1016/s0168-9525(03)00073-8openalex-snapshot

Class II histone deacetylases: versatile regulators

inferredcites →https://doi.org/10.1016/s0168-9525(99)01710-2openalex-snapshot

Molecular genetics of acute promyelocytic leukemia

inferredcites →https://doi.org/10.1016/s0960-9822(00)00445-0openalex-snapshot

Acetylation of importin-α nuclear import factors by CBP/p300

inferredcites →https://doi.org/10.1016/s1097-2765(00)80299-3openalex-snapshot

NURD, a Novel Complex with Both ATP-Dependent Chromatin-Remodeling and Histone Deacetylase Activities

inferredcites →https://doi.org/10.1016/s1097-2765(00)80321-4openalex-snapshot

Oligomerization of RAR and AML1 Transcription Factors as a Novel Mechanism of Oncogenic Activation

inferredcites →https://doi.org/10.1016/s1097-2765(00)80322-6openalex-snapshot

Acquisition of Oncogenic Potential by RAR Chimeras in Acute Promyelocytic Leukemia through Formation of Homodimers

inferredcites →https://doi.org/10.1016/s1097-2765(01)00272-6openalex-snapshot

Regulation of Human Flap Endonuclease-1 Activity by Acetylation through the Transcriptional Coactivator p300

inferredcites →https://doi.org/10.1016/s1097-2765(01)00429-4openalex-snapshot

Enzymatic Activity Associated with Class II HDACs Is Dependent on a Multiprotein Complex Containing HDAC3 and SMRT/N-CoR

inferredcites →https://doi.org/10.1016/s1097-2765(02)00639-1openalex-snapshot

Control of Smad7 Stability by Competition between Acetylation and Ubiquitination

inferredcites →https://doi.org/10.1016/s1097-2765(02)00745-1openalex-snapshot

Acetylation Regulates the DNA End-Trimming Activity of DNA Polymerase β

inferredcites →https://doi.org/10.1016/s1097-2765(04)00094-2openalex-snapshot

Acetylation of the C Terminus of Ku70 by CBP and PCAF Controls Bax-Mediated Apoptosis

inferredcites →https://doi.org/10.1016/s1535-6108(03)00165-xopenalex-snapshot

Histone deacetylase inhibitors in cancer therapy

inferredcites →https://doi.org/10.1016/s1535-6108(04)00114-xopenalex-snapshot

Induction of HDAC2 expression upon loss of APC in colorectal tumorigenesis

inferredcites →https://doi.org/10.1021/jm0303094openalex-snapshot

Histone Deacetylase Inhibitors

inferredcites →https://doi.org/10.1021/jm034167popenalex-snapshot

Discovery of (Aryloxopropenyl)pyrrolyl Hydroxyamides as Selective Inhibitors of Class IIa Histone Deacetylase Homologue HD1-A

inferredcites →https://doi.org/10.1021/jm0497592openalex-snapshot

Subtype Selective Substrates for Histone Deacetylases

inferredcites →https://doi.org/10.1038/35102167openalex-snapshot

Stem cells, cancer, and cancer stem cells

inferredcites →https://doi.org/10.1038/35106079openalex-snapshot

Histone deacetylases and cancer: causes and therapies

inferredcites →https://doi.org/10.1038/43710openalex-snapshot

Structures of a histone deacetylase homologue bound to the TSA and SAHA inhibitors

inferredcites →https://doi.org/10.1038/47412openalex-snapshot

The language of covalent histone modifications

inferredcites →https://doi.org/10.1038/5047openalex-snapshot

Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer

inferredcites →https://doi.org/10.1038/nature01150openalex-snapshot

Establishment of transcriptional competence in early and late S phase

inferredcites →https://doi.org/10.1038/nature01595openalex-snapshot

The structure of DNA in the nucleosome core

inferredcites →https://doi.org/10.1038/nature01899openalex-snapshot

Transcription factor IIB acetylates itself to regulate transcription

inferredcites →https://doi.org/10.1038/nature02625openalex-snapshot

Epigenetics in human disease and prospects for epigenetic therapy

inferredcites →https://doi.org/10.1038/nature03672openalex-snapshot

Global histone modification patterns predict risk of prostate cancer recurrence

inferredcites →https://doi.org/10.1038/nbt0303-255openalex-snapshot

Proteomic analysis of post-translational modifications

inferredcites →https://doi.org/10.1038/ng1018openalex-snapshot

Acetylation inactivates the transcriptional repressor BCL6

inferredcites →https://doi.org/10.1038/ng1531openalex-snapshot

Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer

inferredcites →https://doi.org/10.1038/nm1160openalex-snapshot

Inhibitors of histone deacetylases induce tumor-selective apoptosis through activation of the death receptor pathway

inferredcites →https://doi.org/10.1038/nm1161openalex-snapshot

Tumor-selective action of HDAC inhibitors involves TRAIL induction in acute myeloid leukemia cells

inferredcites →https://doi.org/10.1038/nrc1279openalex-snapshot

The history of cancer epigenetics

inferredcites →https://doi.org/10.1038/nrc1455openalex-snapshot

Post-translational modification of p53 in tumorigenesis

inferredcites →https://doi.org/10.1038/nrd772openalex-snapshot

Histone-deacetylase inhibitors: novel drugs for the treatment of cancer

inferredcites →https://doi.org/10.1038/nrm1368openalex-snapshot

Shaping the nuclear action of NF-κB

inferredcites →https://doi.org/10.1038/nsmb0205-110openalex-snapshot

Reading signals on the nucleosome with a new nomenclature for modified histones

inferredcites →https://doi.org/10.1038/sj.cdd.4401507openalex-snapshot

Sensitization of osteosarcoma cells to death receptor-mediated apoptosis by HDAC inhibitors through downregulation of cellular FLIP

inferredcites →https://doi.org/10.1038/sj.emboj.7600109openalex-snapshot

Impairment of p53 acetylation, stability and function by an oncogenic transcription factor

inferredcites →https://doi.org/10.1038/sj.onc.1204336openalex-snapshot

Histone deacetylases: a common molecular target for differentiation treatment of acute myeloid leukemias?

inferredcites →https://doi.org/10.1038/sj.onc.1207118openalex-snapshot

p300/CBP and cancer

inferredcites →https://doi.org/10.1038/sj.onc.1207830openalex-snapshot

Histone deacetylase inhibitors upregulate death receptor 5/TRAIL-R2 and sensitize apoptosis induced by TRAIL/APO2-L in human malignant tumor cells

inferredcites →https://doi.org/10.1038/sj.onc.1208585openalex-snapshot

HDAC inhibitors enhance the apoptosis-inducing potential of TRAIL in breast carcinoma

inferredcites →https://doi.org/10.1053/j.seminoncol.2003.08.005openalex-snapshot

Emerging roles of MTA family members in human cancers

inferredcites →https://doi.org/10.1056/nejm199105163242002openalex-snapshot

Differentiation Therapy of Acute Promyelocytic Leukemia with Tretinoin (All-trans-Retinoic Acid)

inferredcites →https://doi.org/10.1073/pnas.0307708100openalex-snapshot

Histone deacetylase (HDAC) inhibitor activation of p21 WAF1 involves changes in promoter-associated proteins, including HDAC1

inferredcites →https://doi.org/10.1073/pnas.0404603101openalex-snapshot

Crystal structure of a eukaryotic zinc-dependent histone deacetylase, human HDAC8, complexed with a hydroxamic acid inhibitor

inferredcites →https://doi.org/10.1073/pnas.0408345102openalex-snapshot

Apoptotic and autophagic cell death induced by histone deacetylase inhibitors

inferredcites →https://doi.org/10.1073/pnas.0408351102openalex-snapshot

Ku70 acetylation mediates neuroblastoma cell death induced by histone deacetylase inhibitors

inferredcites →https://doi.org/10.1073/pnas.0408732102openalex-snapshot

Role of thioredoxin in the response of normal and transformed cells to histone deacetylase inhibitors

inferredcites →https://doi.org/10.1073/pnas.0430973100openalex-snapshot

Domain-selective small-molecule inhibitor of histone deacetylase 6 (HDAC6)-mediated tubulin deacetylation

inferredcites →https://doi.org/10.1073/pnas.0500369102openalex-snapshot

Identification and functional significance of genes regulated by structurally different histone deacetylase inhibitors

inferredcites →https://doi.org/10.1073/pnas.0503221102openalex-snapshot

Small-molecule inhibition of proteasome and aggresome function induces synergistic antitumor activity in multiple myeloma

inferredcites →https://doi.org/10.1073/pnas.180316197openalex-snapshot

Histone deacetylase inhibitor selectively induces p21 WAF1 expression and gene-associated histone acetylation

inferredcites →https://doi.org/10.1073/pnas.2536759100openalex-snapshot

Transcriptional signature of histone deacetylase inhibition in multiple myeloma: Biological and clinical implications

inferredcites →https://doi.org/10.1073/pnas.51.5.786openalex-snapshot

ACETYLATION AND METHYLATION OF HISTONES AND THEIR POSSIBLE ROLE IN THE REGULATION OF RNA SYNTHESIS

inferredcites →https://doi.org/10.1073/pnas.94.6.2551openalex-snapshot

A PMLRAR α transgene initiates murine acute promyelocytic leukemia

inferredcites →https://doi.org/10.1073/pnas.95.12.6791openalex-snapshot

p21 WAF1 is required for butyrate-mediated growth inhibition of human colon cancer cells

inferredcites →https://doi.org/10.1074/jbc.c000879200openalex-snapshot

Multiple N-CoR Complexes Contain Distinct Histone Deacetylases

inferredcites →https://doi.org/10.1074/jbc.c500186200openalex-snapshot

Inhibition of Histone Deacetylase 6 Acetylates and Disrupts the Chaperone Function of Heat Shock Protein 90

inferredcites →https://doi.org/10.1074/jbc.m007372200openalex-snapshot

Stable Histone Deacetylase Complexes Distinguished by the Presence of SANT Domain Proteins CoREST/kiaa0071 and Mta-L1

inferredcites →https://doi.org/10.1074/jbc.m207484200openalex-snapshot

Acetylation of Interferon Regulatory Factor-7 by p300/CREB-binding Protein (CBP)-associated Factor (PCAF) Impairs its DNA Binding

inferredcites →https://doi.org/10.1074/jbc.m302955200openalex-snapshot

The Metastasis-associated Proteins 1 and 2 Form Distinct Protein Complexes with Histone Deacetylase Activity

inferredcites →https://doi.org/10.1074/jbc.m313120200openalex-snapshot

Transforming Growth Factor-β Stimulates p300-dependent RUNX3 Acetylation, Which Inhibits Ubiquitination-mediated Degradation

inferredcites →https://doi.org/10.1074/jbc.m407472200openalex-snapshot

Stability of the Hepatocyte Nuclear Factor 6 Transcription Factor Requires Acetylation by the CREB-binding Protein Coactivator

inferredcites →https://doi.org/10.1074/jbc.m408063200openalex-snapshot

ICI182,780 Induces p21 Gene Transcription through Releasing Histone Deacetylase 1 and Estrogen Receptor α from Sp1 Sites to Induce Cell Cycle Arrest in MCF-7 Breast Cancer Cell Line

inferredcites →https://doi.org/10.1074/jbc.m413930200openalex-snapshot

Activation of Stat3 Sequence-specific DNA Binding and Transcription by p300/CREB-binding Protein-mediated Acetylation

inferredcites →https://doi.org/10.1074/jbc.m504482200openalex-snapshot

Arrest-defective-1 Protein, an Acetyltransferase, Does Not Alter Stability of Hypoxia-inducible Factor (HIF)-1α and Is Not Induced by Hypoxia or HIF

inferredcites →https://doi.org/10.1081/ias-200041153openalex-snapshot

Development of a PAN-Specific, Affinity-Purified Anti-acetylated Lysine Antibody for Detection, Identification, Isolation, and Intracellular Localization of Acetylated Protein

inferredcites →https://doi.org/10.1091/mbc.11.6.2069openalex-snapshot

Histone Deacetylase Inhibitors Trigger a G2 Checkpoint in Normal Cells That Is Defective in Tumor Cells

inferredcites →https://doi.org/10.1093/emboj/19.16.4342openalex-snapshot

Both corepressor proteins SMRT and N‐CoR exist in large protein complexes containing HDAC3

inferredcites →https://doi.org/10.1093/emboj/19.6.1176openalex-snapshot

Acetylation: a regulatory modification to rival phosphorylation?

inferredcites →https://doi.org/10.1093/emboj/21.11.2672openalex-snapshot

Essential function of histone deacetylase 1 in proliferation control and CDK inhibitor repression

inferredcites →https://doi.org/10.1093/emboj/cdg516openalex-snapshot

Monocytic cells hyperacetylate chromatin protein HMGB1 to redirect it towards secretion

inferredcites →https://doi.org/10.1093/nar/25.18.3693openalex-snapshot

Histone deacetylases, acetoin utilization proteins and acetylpolyamine amidohydrolases are members of an ancient protein superfamily

inferredcites →https://doi.org/10.1096/fj.02-1003fjeopenalex-snapshot

Tumor cell‐specific cytotoxicity by targeting cell cycle checkpoints

inferredcites →https://doi.org/10.1101/gad.1232504openalex-snapshot

Epigenetics and cancer

inferredcites →https://doi.org/10.1101/gad.13.15.1924openalex-snapshot

Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation

inferredcites →https://doi.org/10.1101/gad.14.1.45openalex-snapshot

Nuclear receptor corepressors partner with class II histone deacetylases in a Sin3-independent repression pathway

inferredcites →https://doi.org/10.1101/gad.14.9.1048openalex-snapshot

A core SMRT corepressor complex containing HDAC3 and TBL1, a WD40-repeat protein linked to deafness

inferredcites →https://doi.org/10.1101/sqb.1994.059.01.012openalex-snapshot

The Adenovirus E1A-associated 300-kD Protein Exhibits Properties of a Transcriptional Coactivator and Belongs to an Evolutionarily Conserved Family

inferredcites →https://doi.org/10.1124/jpet.105.083956openalex-snapshot

Chemoresistance to Depsipeptide FK228 [(E)-(1 S,4 S,10 S,21 R)-7-[(Z)-Ethylidene]-4,21-diisopropyl-2-oxa-12,13-dithia-5,8,20,23-tetraazabicyclo[8,7,6]-tricos-16-ene-3,6,9,22-pentanone] Is Mediated by Reversible MDR1 Induction in Human Cancer Cell Lines

inferredcites →https://doi.org/10.1124/mol.104.007831openalex-snapshot

Cotreatment with Suberanoylanilide Hydroxamic Acid and 17-Allylamino 17-demethoxygeldanamycin Synergistically Induces Apoptosis in Bcr-Abl+ Cells Sensitive and Resistant to STI571 (Imatinib Mesylate) in Association with Down-Regulation of Bcr-Abl, Abrogation of Signal Transducer and Activator of…

inferredcites →https://doi.org/10.1126/science.1065173openalex-snapshot

Methyltransferase Recruitment and DNA Hypermethylation of Target Promoters by an Oncogenic Transcription Factor

inferredcites →https://doi.org/10.1126/science.1099196openalex-snapshot

Calorie Restriction Promotes Mammalian Cell Survival by Inducing the SIRT1 Deacetylase

inferredcites →https://doi.org/10.1126/science.1105166openalex-snapshot

Stat3 Dimerization Regulated by Reversible Acetylation of a Single Lysine Residue

inferredcites →https://doi.org/10.1126/science.293.5532.1133openalex-snapshot

Coordination of a Transcriptional Switch by HMGI(Y) Acetylation

inferredcites →https://doi.org/10.1128/mcb.21.23.8035-8044.2001openalex-snapshot

Identification of Components of the Murine Histone Deacetylase 6 Complex: Link between Acetylation and Ubiquitination Signaling Pathways

inferredcites →https://doi.org/10.1128/mcb.23.21.7719-7731.2003openalex-snapshot

Histone Deacetylation of RB-Responsive Promoters: Requisite for Specific Gene Repression but Dispensable for Cell Cycle Inhibition

inferredcites →https://doi.org/10.1128/mcb.23.3.1025-1033.2003openalex-snapshot

Interaction of Histone Acetylases and Deacetylases In Vivo

inferredcites →https://doi.org/10.1128/mcb.23.7.2587-2599.2003openalex-snapshot

Coactivator-Dependent Acetylation Stabilizes Members of the SREBP Family of Transcription Factors

inferredcites →https://doi.org/10.1146/annurev.biochem.73.011303.073651openalex-snapshot

The Sir2 Family of Protein Deacetylases

inferredcites →https://doi.org/10.1146/annurev.pharmtox.45.120403.095825openalex-snapshot

CLINICAL DEVELOPMENT OF HISTONE DEACETYLASE INHIBITORS AS ANTICANCER AGENTS

inferredcites →https://doi.org/10.1158/0008-5472.can-03-2630openalex-snapshot

Enhanced Radiation-Induced Cell Killing and Prolongation of γH2AX Foci Expression by the Histone Deacetylase Inhibitor MS-275

inferredcites →https://doi.org/10.1158/0008-5472.can-03-3897openalex-snapshot

Overexpression of Histone Deacetylase 1 Confers Resistance to Sodium Butyrate–Mediated Apoptosis in Melanoma Cells through a p53-Mediated Pathway

inferredcites →https://doi.org/10.1158/1078-0432.ccr-03-0709openalex-snapshot

Class I Histone Deacetylase-Selective Novel Synthetic Inhibitors Potently Inhibit Human Tumor Proliferation

inferredcites →https://doi.org/10.1158/1078-0432.ccr-04-2088openalex-snapshot

Histone Deacetylase Inhibitors Radiosensitize Human Melanoma Cells by Suppressing DNA Repair Activity

inferredcites →https://doi.org/10.1172/jci11537openalex-snapshot

Histone deacetylase inhibitors induce remission in transgenic models of therapy-resistant acute promyelocytic leukemia

inferredcites →https://doi.org/10.1182/blood-2003-07-2431openalex-snapshot

Modification of hematopoietic stem cell fate by 5aza 2′deoxycytidine and trichostatin A

inferredcites →https://doi.org/10.1182/blood-2003-09-3068openalex-snapshot

T-cell lymphoma as a model for the use of histone deacetylase inhibitors in cancer therapy: impact of depsipeptide on molecular markers, therapeutic targets, and mechanisms of resistance

inferredcites →https://doi.org/10.1182/blood-2004-05-1693openalex-snapshot

A phase 1 and pharmacodynamic study of depsipeptide (FK228) in chronic lymphocytic leukemia and acute myeloid leukemia

inferredcites →https://doi.org/10.1182/blood.v89.2.376openalex-snapshot

Altered Myeloid Development and Acute Leukemia in Transgenic Mice Expressing PML-RARα Under Control of Cathepsin G Regulatory Sequences

inferredcites →https://doi.org/10.1182/blood.v98.9.2865openalex-snapshot

Inhibitor of histone deacetylation, depsipeptide (FR901228), in the treatment of peripheral and cutaneous T-cell lymphoma: a case report

inferredcites →https://doi.org/10.1186/1476-4598-4-22openalex-snapshot

Histone acetylation and histone deacetylase activity of magnesium valproate in tumor and peripheral blood of patients with cervical cancer. A phase I study

inferredcites →https://doi.org/10.1200/jco.2005.02.188openalex-snapshot

Phase I and Pharmacokinetic Study of MS-275, a Histone Deacetylase Inhibitor, in Patients With Advanced and Refractory Solid Tumors or Lymphoma

inferredcites →https://doi.org/10.1200/jco.2005.14.167openalex-snapshot

Phase I Study of an Oral Histone Deacetylase Inhibitor, Suberoylanilide Hydroxamic Acid, in Patients With Advanced Cancer

inferredcites →https://doi.org/10.1242/dev.01213openalex-snapshot

Metastasis-associated protein 1 deregulation causes inappropriate mammary gland development and tumorigenesis

inferredcites →https://doi.org/10.1385/1-59259-811-0:245openalex-snapshot

Analysis of Checkpoint Responses to Histone Deacetylase Inhibitors

inferredcites →https://doi.org/10.1517/13543784.13.1.21openalex-snapshot

Histone deacetylase inhibitors in clinical development

inferredcites →https://doi.org/10.3892/ijmm.9.5.521openalex-snapshot

Histone deacetylase inhibitors sensitize human colonic adenocarcinoma cell lines to TNF-related apoptosis inducing ligand-mediated apoptosis

inferredcites →https://doi.org/10.4161/cbt.3.9.1103openalex-snapshot

Altered epigenetic signals in human disease

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Leukemia-Associated Fusion Proteins: Multiple Mechanisms of Action to Drive Cell Transformation

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Lysine (K)-Deacetylase Inhibitors: The Real Next Step To Neuropsychiatric And Neurodegenerative Disorders?

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Determination of Protein Lysine Deacetylation

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Assessment of Histone Acetylation Levels in Relation to Cell Cycle Phase

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Belinostat exerts antitumor cytotoxicity through the ubiquitin‐proteasome pathway in lung squamous cell carcinoma

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Histone deacetylase 2 is involved in DNA damage‐mediated cell death of human osteosarcoma cells through stimulation of the ATM /p53 pathway

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Histone Acetylation and Deacetylation

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inferred← citeshttps://doi.org/10.1002/9781118005743.ch14openalex-snapshot

Epigenetic Targets and Drug Development

inferred← citeshttps://doi.org/10.1002/9781118005743.ch5openalex-snapshot

Epigenetic Control of Gene Transcription

inferred← citeshttps://doi.org/10.1002/9781118005743.ch7openalex-snapshot

The Role of Epigenetic Modifications in Cancer

inferred← citeshttps://doi.org/10.1002/9781118005743.ch9openalex-snapshot

Epigenetics in Pediatric Cancers

inferred← citeshttps://doi.org/10.1002/9781118682975.ch1openalex-snapshot

New Applications of Immobilized Metal Ion Affinity Chromatography in Chemical Biology

inferred← citeshttps://doi.org/10.1002/9783527619375.ch12openalex-snapshot

The Bicyclic Depsipeptide Family of Histone Deacetylase Inhibitors

inferred← citeshttps://doi.org/10.1002/9783527625970.ch8openalex-snapshot

Epigenetically‐Regulated Therapeutic Tumor‐Associated Antigens

inferred← citeshttps://doi.org/10.1002/9783527627073.ch12openalex-snapshot

Histone Methyltransferases as Novel Drug Targets

inferred← citeshttps://doi.org/10.1002/9783527627073.ch9openalex-snapshot

Histone Deacetylase Inhibitors

inferred← citeshttps://doi.org/10.1002/9783527676545.ch16openalex-snapshot

Hybrids, Congeners, Mimics, and Constrained Variants Spanning 30 Years of Natural Products Chemistry: A Personal Retrospective

inferred← citeshttps://doi.org/10.1002/9783527800315.ch5openalex-snapshot

Discovery and Development of HDAC Subtype Selective Inhibitor Chidamide: Potential Immunomodulatory Activity Against Cancers

inferred← citeshttps://doi.org/10.1002/advs.202001515openalex-snapshot

CUL4B Promotes Breast Carcinogenesis by Coordinating with Transcriptional Repressor Complexes in Response to Hypoxia Signaling Pathway

inferred← citeshttps://doi.org/10.1002/advs.202200705openalex-snapshot

Transcriptional Repression of Aerobic Glycolysis by OVOL2 in Breast Cancer

inferred← citeshttps://doi.org/10.1002/advs.202404608openalex-snapshot

A Live‐Cell Epigenome Manipulation by Photo‐Stimuli‐Responsive Histone Methyltransferase Inhibitor

inferred← citeshttps://doi.org/10.1002/ajh.23112openalex-snapshot

The histone deacetylase inhibitor, romidepsin, suppresses cellular immune functions of cutaneous T‐cell lymphoma patients

inferred← citeshttps://doi.org/10.1002/ange.200602033openalex-snapshot

Total Synthesis of Azumamides A and E

inferred← citeshttps://doi.org/10.1002/ange.200602047openalex-snapshot

Azumamides A–E: Histone Deacetylase Inhibitory Cyclic Tetrapeptides from the Marine Sponge Mycale izuensis

inferred← citeshttps://doi.org/10.1002/ange.200805900openalex-snapshot

Probing the Bioactive Conformation of an Archetypal Natural Product HDAC Inhibitor with Conformationally Homogeneous Triazole‐Modified Cyclic Tetrapeptides

inferred← citeshttps://doi.org/10.1002/ange.200904761openalex-snapshot

Untersuchung der Biologie von Naturstoffen: systematische Strukturvariation durch umgelenkte Totalsynthese

inferred← citeshttps://doi.org/10.1002/ange.201108118openalex-snapshot

Discovery of Macrocyclic Peptides Armed with a Mechanism‐Based Warhead: Isoform‐Selective Inhibition of Human Deacetylase SIRT2

inferred← citeshttps://doi.org/10.1002/ange.201209385openalex-snapshot

Probing Arginine Side‐Chains and Their Dynamics with Carbon‐Detected NMR Spectroscopy: Application to the 42 kDa Human Histone Deacetylase 8 at High pH

inferred← citeshttps://doi.org/10.1002/ange.201307803openalex-snapshot

Preparation of Small‐Molecule Microarrays by trans‐Cyclooctene Tetrazine Ligation and Their Application in the High‐Throughput Screening of Protein–Protein Interaction Inhibitors of Bromodomains

inferred← citeshttps://doi.org/10.1002/ange.201511308openalex-snapshot

In‐Bead Screening of Hydroxamic Acids for the Identification of HDAC Inhibitors

inferred← citeshttps://doi.org/10.1002/anie.200602033openalex-snapshot

Total Synthesis of Azumamides A and E

inferred← citeshttps://doi.org/10.1002/anie.200602047openalex-snapshot

Azumamides A–E: Histone Deacetylase Inhibitory Cyclic Tetrapeptides from the Marine Sponge Mycale izuensis

inferred← citeshttps://doi.org/10.1002/anie.200805900openalex-snapshot

Probing the Bioactive Conformation of an Archetypal Natural Product HDAC Inhibitor with Conformationally Homogeneous Triazole‐Modified Cyclic Tetrapeptides

inferred← citeshttps://doi.org/10.1002/anie.200904761openalex-snapshot

Probing the Biology of Natural Products: Molecular Editing by Diverted Total Synthesis

inferred← citeshttps://doi.org/10.1002/anie.201108118openalex-snapshot

Discovery of Macrocyclic Peptides Armed with a Mechanism‐Based Warhead: Isoform‐Selective Inhibition of Human Deacetylase SIRT2

inferred← citeshttps://doi.org/10.1002/anie.201209385openalex-snapshot

Probing Arginine Side‐Chains and Their Dynamics with Carbon‐Detected NMR Spectroscopy: Application to the 42 kDa Human Histone Deacetylase 8 at High pH

inferred← citeshttps://doi.org/10.1002/anie.201307803openalex-snapshot

inferred← citeshttps://doi.org/10.1002/anie.201511308openalex-snapshot

In‐Bead Screening of Hydroxamic Acids for the Identification of HDAC Inhibitors

inferred← citeshttps://doi.org/10.1002/ardp.201500472openalex-snapshot

Structural Requirements of Histone Deacetylase Inhibitors: SAHA Analogs Modified on the Hydroxamic Acid

inferred← citeshttps://doi.org/10.1002/ardp.202400889openalex-snapshot

New potent N‐hydroxycinnamamide‐based histone deacetylase inhibitors suppress proliferation and trigger apoptosis in THP‐1 leukaemia cells

inferred← citeshttps://doi.org/10.1002/asia.201700339openalex-snapshot

Copper(I)‐Mediated Denitrogenative Macrocyclization for the Synthesis of Cyclic α3β‐Tetrapeptide Analogues

inferred← citeshttps://doi.org/10.1002/bdrc.20082openalex-snapshot

Inhibition of histone deacetylase as a new mechanism of teratogenesis

inferred← citeshttps://doi.org/10.1002/bip.22744openalex-snapshot

Review structure‐ and dynamics‐based computational design of anticancer drugs

inferred← citeshttps://doi.org/10.1002/cam4.3410openalex-snapshot

Study and analysis of antitumor resistance mechanism of PD1/PD‐L1 immune checkpoint blocker

inferred← citeshttps://doi.org/10.1002/cbf.3084openalex-snapshot

Trichostatin a modulates intracellular reactive oxygen species through SOD2 and FOXO1 in human bone marrow‐mesenchymal stem cells

inferred← citeshttps://doi.org/10.1002/cbf.3626openalex-snapshot

Epigenetic modulators combination with chemotherapy in breast cancer cells

inferred← citeshttps://doi.org/10.1002/cbic.200700586openalex-snapshot

Identification, Synthesis, and Enzymology of Non‐natural Glucosinolate Chemopreventive Candidates

inferred← citeshttps://doi.org/10.1002/cbic.200900721openalex-snapshot

The Identification of a Novel Natural Activator of p300 Histone Acetyltranferase Provides New Insights into the Modulation Mechanism of this Enzyme

inferred← citeshttps://doi.org/10.1002/cbic.201000558openalex-snapshot

Chemical Approaches for the Detection and Synthesis of Acetylated Proteins

inferred← citeshttps://doi.org/10.1002/cbic.201300201openalex-snapshot

1‐Arylsulfonyl‐5‐(N‐hydroxyacrylamide)indolines Histone Deacetylase Inhibitors Are Potent Cytokine Release Suppressors

inferred← citeshttps://doi.org/10.1002/chem.200901552openalex-snapshot

Total Synthesis of the Bicyclic Depsipeptide HDAC Inhibitors Spiruchostatins A and B, 5′′‐epi‐Spiruchostatin B, FK228 (FR901228) and Preliminary Evaluation of Their Biological Activity

inferred← citeshttps://doi.org/10.1002/chem.201300814openalex-snapshot

Histone‐Deacetylase‐Targeted Fluorescent Ruthenium(II) Polypyridyl Complexes as Potent Anticancer Agents

inferred← citeshttps://doi.org/10.1002/chem.201502809openalex-snapshot

Light‐Controlled Histone Deacetylase (HDAC) Inhibitors: Towards Photopharmacological Chemotherapy

inferred← citeshttps://doi.org/10.1002/cmdc.200600203openalex-snapshot

Structure‐Based Organic Synthesis of Drug Prototypes: A Personal Odyssey

inferred← citeshttps://doi.org/10.1002/cmdc.200800096openalex-snapshot

Synthesis of Benzamides Related to Anacardic Acid and Their Histone Acetyltransferase (HAT) Inhibitory Activities

inferred← citeshttps://doi.org/10.1002/cmdc.200800196openalex-snapshot

Pyridylalanine‐Containing Hydroxamic Acids as Selective HDAC6 Inhibitors

inferred← citeshttps://doi.org/10.1002/cmdc.200800461openalex-snapshot

Studies of Benzamide‐ and Thiol‐Based Histone Deacetylase Inhibitors in Models of Oxidative‐Stress‐Induced Neuronal Death: Identification of Some HDAC3‐Selective Inhibitors

inferred← citeshttps://doi.org/10.1002/cmdc.200900045openalex-snapshot

Searching for Disease Modifiers—PKC Activation and HDAC Inhibition—A Dual Drug Approach to Alzheimer's Disease that Decreases Aβ Production while Blocking Oxidative Stress

inferred← citeshttps://doi.org/10.1002/cmdc.200900082openalex-snapshot

Pyrrole‐Based Hydroxamates and 2‐Aminoanilides: Histone Deacetylase Inhibition and Cellular Activities

inferred← citeshttps://doi.org/10.1002/cmdc.200900309openalex-snapshot

Azetidinones as Zinc‐Binding Groups to Design Selective HDAC8 Inhibitors

inferred← citeshttps://doi.org/10.1002/cmdc.201000158openalex-snapshot

New Anacardic Acid‐Inspired Benzamides: Histone Lysine Acetyltransferase Activators

inferred← citeshttps://doi.org/10.1002/cmdc.201000166openalex-snapshot

Synthesis and Biological Characterization of Amidopropenyl Hydroxamates as HDAC Inhibitors

inferred← citeshttps://doi.org/10.1002/cmdc.201000535openalex-snapshot

Novel Cinnamyl Hydroxyamides and 2‐Aminoanilides as Histone Deacetylase Inhibitors: Apoptotic Induction and Cytodifferentiation Activity

inferred← citeshttps://doi.org/10.1002/cmdc.201100007openalex-snapshot

Carbamate Prodrug Concept for Hydroxamate HDAC Inhibitors

inferred← citeshttps://doi.org/10.1002/cmdc.201200024openalex-snapshot

Spiro[chromane‐2,4′‐piperidine]‐Based Histone Deacetylase Inhibitors with Improved in vivo Activity

inferred← citeshttps://doi.org/10.1002/cmdc.201200193openalex-snapshot

Design, Synthesis, and Biological Evaluation of 2‐Aminobenzanilide Derivatives as Potent and Selective HDAC Inhibitors

inferred← citeshttps://doi.org/10.1002/cmdc.201200529openalex-snapshot

Discovery of Pyridone‐Based Histone Deacetylase Inhibitors: Approaches for Metabolic Stability

inferred← citeshttps://doi.org/10.1002/cmdc.201300413openalex-snapshot

Towards Selective Inhibition of Histone Deacetylase Isoforms: What Has Been Achieved, Where We Are and What Will Be Next

inferred← citeshttps://doi.org/10.1002/cmdc.201300433openalex-snapshot

The Effect of Various Zinc Binding Groups on Inhibition of Histone Deacetylases 1–11

inferred← citeshttps://doi.org/10.1002/cmdc.201300444openalex-snapshot

Lysine Deacetylase (KDAC) Regulatory Pathways: an Alternative Approach to Selective Modulation

inferred← citeshttps://doi.org/10.1002/cmdc.201402371openalex-snapshot

Identification of Structural Features of 2‐Alkylidene‐1,3‐Dicarbonyl Derivatives that Induce Inhibition and/or Activation of Histone Acetyltransferases KAT3B/p300 and KAT2B/PCAF

inferred← citeshttps://doi.org/10.1002/cmdc.201700449openalex-snapshot

Design, Synthesis, Molecular Modeling, and Biological Evaluation of Novel Amine‐based Histone Deacetylase Inhibitors

inferred← citeshttps://doi.org/10.1002/cmdc.202000854openalex-snapshot

Novel Pyridine‐Based Hydroxamates and 2′‐Aminoanilides as Histone Deacetylase Inhibitors: Biochemical Profile and Anticancer Activity

inferred← citeshttps://doi.org/10.1002/cmdc.202001004openalex-snapshot

Mechanistic Exploration of Methionine 274 Acting as a “Switch” of the Selective Pocket Involved in HDAC8 Inhibition: An in Silico Study

inferred← citeshttps://doi.org/10.1002/cmdc.202200614openalex-snapshot

Switching the Mode of Cell Death between Apoptosis and Autophagy by Histone Deacetylase 6 Inhibition Levels

inferred← citeshttps://doi.org/10.1002/cmdc.202300108openalex-snapshot

Design, Synthesis, and Biological Evaluation of Histone Deacetylase Inhibitors Derived from Erianin and Its Derivatives

inferred← citeshttps://doi.org/10.1002/cmdc.202500322openalex-snapshot

Discovery of Pyrazolo[1, 5‐a]pyrimidine‐Based Selective HDAC6 Inhibitors with Broad‐Spectrum Antiproliferative Activity

inferred← citeshttps://doi.org/10.1002/cncr.22652openalex-snapshot

Epigenetic combination therapy as a tumor‐selective treatment approach for hepatocellular carcinoma

inferred← citeshttps://doi.org/10.1002/cncr.23619openalex-snapshot

Novel 2‐step synthetic indole compound 1,1,3‐tri(3‐indolyl)cyclohexane inhibits cancer cell growth in lung cancer cells and xenograft models

inferred← citeshttps://doi.org/10.1002/cncr.25649openalex-snapshot

Trichostatin A restores Apaf‐1 function in chemoresistant ovarian cancer cells

inferred← citeshttps://doi.org/10.1002/cncr.28356openalex-snapshot

Histone modification patterns correlate with patient outcome in oral squamous cell carcinoma

inferred← citeshttps://doi.org/10.1002/cncr.29229openalex-snapshot

Paclitaxel/carboplatin with or without belinostat as empiric first‐line treatment for patients with carcinoma of unknown primary site: A randomized, phase 2 trial

inferred← citeshttps://doi.org/10.1002/cncr.30949openalex-snapshot

Phase 1 dose escalation multicenter trial of pracinostat alone and in combination with azacitidine in patients with advanced hematologic malignancies

inferred← citeshttps://doi.org/10.1002/cpdd.1448openalex-snapshot

The Bioequivalence of Abexinostat (CRA‐024781) Tosylate Tablets (20 mg) in Chinese Healthy Subjects Under Fasting Conditions

inferred← citeshttps://doi.org/10.1002/ctm2.975openalex-snapshot

Integrative genome‐wide chromatin accessibility and transcriptome profiling of diffuse large B‐cell lymphoma

inferred← citeshttps://doi.org/10.1002/ejoc.201901852openalex-snapshot

Gold‐Catalyzed Regioselective Synthesis of Pyrazolo[1,4]oxazepines via Intramolecular 7‐endo‐dig Cyclization

inferred← citeshttps://doi.org/10.1002/emmm.201302796openalex-snapshot

Synergistic combination of valproic acid and oncolytic parvovirus H‐1PV as a potential therapy against cervical and pancreatic carcinomas

inferred← citeshttps://doi.org/10.1002/hed.21755openalex-snapshot

Novel molecular targeted therapies for refractory thyroid cancer

inferred← citeshttps://doi.org/10.1002/hep.21804openalex-snapshot

Efficacy of a novel histone deacetylase inhibitor in murine models of hepatocellular carcinoma

inferred← citeshttps://doi.org/10.1002/hep.26542openalex-snapshot

Loss of histone deacetylases 1 and 2 in hepatocytes impairs murine liver regeneration through Ki67 depletion

inferred← citeshttps://doi.org/10.1002/hep.27209openalex-snapshot

Cylindromatosis gene CYLD regulates hepatocyte growth factor expression in hepatic stellate cells through interaction with histone deacetylase 7

inferred← citeshttps://doi.org/10.1002/hep.28887openalex-snapshot

Acetylation of PGK1 promotes liver cancer cell proliferation and tumorigenesis

inferred← citeshttps://doi.org/10.1002/hon.3088openalex-snapshot

Chidamide: Targeting epigenetic regulation in the treatment of hematological malignancy

inferred← citeshttps://doi.org/10.1002/ibd.21628openalex-snapshot

STAT6 activation in ulcerative colitis: A new target for prevention of IL-13-induced colon epithelial cell dysfunction

inferred← citeshttps://doi.org/10.1002/ijc.23094openalex-snapshot

Protein kinase CK2 is a key activator of histone deacetylase in hypoxia‐associated tumors

inferred← citeshttps://doi.org/10.1002/ijc.23243openalex-snapshot

Activity of the histone deacetylase inhibitor belinostat (PXD101) in preclinical models of prostate cancer

inferred← citeshttps://doi.org/10.1002/ijc.23295openalex-snapshot

Histone deacetylase inhibitor Helminthosporium carbonum (HC)‐toxin suppresses the malignant phenotype of neuroblastoma cells

inferred← citeshttps://doi.org/10.1002/ijc.23885openalex-snapshot

Defining the molecular action of HDAC inhibitors and synergism with androgen deprivation in ERG‐positive prostate cancer

inferred← citeshttps://doi.org/10.1002/ijc.25151openalex-snapshot

Type‐specific roles of histone deacetylase (HDAC) overexpression in ovarian carcinoma: HDAC1 enhances cell proliferation and HDAC3 stimulates cell migration with downregulation of E‐cadherin

inferred← citeshttps://doi.org/10.1002/ijc.25170openalex-snapshot

Histone deacetylase inhibitor‐induced sensitization to TNFα/TRAIL‐mediated apoptosis in cervical carcinoma cells is dependent on HPV oncogene expression

inferred← citeshttps://doi.org/10.1002/ijc.26241openalex-snapshot

Histone deacetylase inhibition as an anticancer telomerase‐targeting strategy

inferred← citeshttps://doi.org/10.1002/ijc.29320openalex-snapshot

The combination of irreversible EGFR TKI s and SAHA induces apoptosis and autophagy‐mediated cell death to overcome acquired resistance in EGFR T 790 M ‐mutated lung cancer

inferred← citeshttps://doi.org/10.1002/ijc.30664openalex-snapshot

A histone deacetylase inhibitor enhances expression of genes inhibiting Wnt pathway and augments activity of DNA demethylation reagent against nonsmall-cell lung cancer

inferred← citeshttps://doi.org/10.1002/ijch.201600130openalex-snapshot

Synthesis and Biochemical Evaluation of Biotinylated Conjugates of Largazole Analogues: Selective Class I Histone Deacetylase Inhibitors

inferred← citeshttps://doi.org/10.1002/jbio.201100061openalex-snapshot

Fourier transform infrared microspectroscopy identifies protein propionylation in histone deacetylase inhibitor treated glioma cells

inferred← citeshttps://doi.org/10.1002/jbm.a.37192openalex-snapshot

Engineered synthetic cell penetrating peptide with intracellular anti‐inflammatory bioactivity: An in vitro and in vivo study

inferred← citeshttps://doi.org/10.1002/jcb.21316openalex-snapshot

Expression of cyclin D3 through Sp1 sites by histone deacetylase inhibitors is mediated with protein kinase C‐δ (PKC‐δ) signal pathway

inferred← citeshttps://doi.org/10.1002/jcb.21485openalex-snapshot

Chromatin organization and nuclear microenvironments in cancer cells

inferred← citeshttps://doi.org/10.1002/jcb.21486openalex-snapshot

Histone deacetylases in control of skeletogenesis

inferred← citeshttps://doi.org/10.1002/jcb.22185openalex-snapshot

Histone deacetylase inhibitors: Potential in cancer therapy

inferred← citeshttps://doi.org/10.1002/jcb.23403openalex-snapshot

A systems biology approach to identify molecular pathways altered by HDAC inhibition in osteosarcoma

inferred← citeshttps://doi.org/10.1002/jcb.24090openalex-snapshot

HDAC2 overexpression confers oncogenic potential to human lung cancer cells by deregulating expression of apoptosis and cell cycle proteins

inferred← citeshttps://doi.org/10.1002/jcb.24802openalex-snapshot

Class II HDACs and Neuronal Regeneration

inferred← citeshttps://doi.org/10.1002/jcb.26133openalex-snapshot

A Mercaptoacetamide‐Based Class II Histone Deacetylase Inhibitor Suppresses Cell Migration and Invasion in Monomorphic Malignant Human Glioma Cells by Inhibiting FAK/STAT3 Signaling

inferred← citeshttps://doi.org/10.1002/jcb.28193openalex-snapshot

Downregulation of HDAC2 and HDAC3 via oleuropein as a potent prevention and therapeutic agent in MCF‐7 breast cancer cells

inferred← citeshttps://doi.org/10.1002/jcb.29583openalex-snapshot

Exploring the binding mechanism of HDAC8 selective inhibitors: Lessons from the modification of Cap group

inferred← citeshttps://doi.org/10.1002/jcp.24039openalex-snapshot

Organosulfur derivatives of the HDAC inhibitor valproic acid sensitize human lung cancer cell lines to apoptosis and to cisplatin cytotoxicity

inferred← citeshttps://doi.org/10.1002/jcp.25273openalex-snapshot

Nuclear Phosphatidylinositol Signaling: Focus on Phosphatidylinositol Phosphate Kinases and Phospholipases C

inferred← citeshttps://doi.org/10.1002/jcp.29882openalex-snapshot

Phospholipase D1 is upregulated by vorinostat and confers resistance to vorinostat in glioblastoma

inferred← citeshttps://doi.org/10.1002/jgm.1522openalex-snapshot

Antiglioma effects of combined use of a baculovirual vector expressing wild‐type p53 and sodium butyrate

inferred← citeshttps://doi.org/10.1002/jha2.70127openalex-snapshot

Targeted Degradation of Class 1 HDACs With PROTACs is Highly Effective at Inducing DLBCL Cell Death

inferred← citeshttps://doi.org/10.1002/lary.22392openalex-snapshot

Preclinical validation of AR42, a novel histone deacetylase inhibitor, as treatment for vestibular schwannomas

inferred← citeshttps://doi.org/10.1002/mc.20373openalex-snapshot

HDAC3 overexpression and colon cancer cell proliferation and differentiation

inferred← citeshttps://doi.org/10.1002/mco2.70500openalex-snapshot

Preclinical Characterization of SDFZ‐8, a Highly Potent HDAC1 Inhibitor, for Cancer Immunotherapy

inferred← citeshttps://doi.org/10.1002/med.20169openalex-snapshot

Strategies in developing promising histone deacetylase inhibitors

inferred← citeshttps://doi.org/10.1002/med.20200openalex-snapshot

Histone deacetylase inhibitors (HDACIs). Structure—activity relationships: history and new QSAR perspectives

inferred← citeshttps://doi.org/10.1002/mgg3.613openalex-snapshot

Sodium butyrate and panobinostat induce apoptosis of chronic myeloid leukemia cells via multiple pathways

inferred← citeshttps://doi.org/10.1002/minf.202100295openalex-snapshot

Discovery of Potent and Isoform‐selective Histone Deacetylase Inhibitors Using Structure‐based Virtual Screening and Biological Evaluation

inferred← citeshttps://doi.org/10.1002/mrd.23659openalex-snapshot

The role of histone deacetylases in embryonic development

inferred← citeshttps://doi.org/10.1002/path.2434openalex-snapshot

SAHA induces caspase‐independent, autophagic cell death of endometrial stromal sarcoma cells by influencing the mTOR pathway

inferred← citeshttps://doi.org/10.1002/path.2554openalex-snapshot

The histone deacetylase inhibitor LBH589 inhibits expression of mitotic genes causing G2/M arrest and cell death in head and neck squamous cell carcinoma cell lines

inferred← citeshttps://doi.org/10.1002/path.5108openalex-snapshot

Activation of MET signaling by HDAC6 offers a rationale for a novel ricolinostat and crizotinib combinatorial therapeutic strategy in diffuse large B‐cell lymphoma

inferred← citeshttps://doi.org/10.1002/pbc.24724openalex-snapshot

Initial testing (stage 1) of the histone deacetylase inhibitor, quisinostat (JNJ-26481585), by the Pediatric Preclinical Testing Program

inferred← citeshttps://doi.org/10.1002/phar.1408openalex-snapshot

Epigenetics and Oncology

inferred← citeshttps://doi.org/10.1002/pmic.200800866openalex-snapshot

Histone post‐translational modifications by HPLC‐ESI‐MS after HT29 cell treatment with histone deacetylase inhibitors

inferred← citeshttps://doi.org/10.1002/pmic.200900602openalex-snapshot

Screening for therapeutic targets of vorinostat by SILAC‐based proteomic analysis in human breast cancer cells

inferred← citeshttps://doi.org/10.1002/pro.2317openalex-snapshot

Inactivating mutation in histone deacetylase 3 stabilizes its active conformation

inferred← citeshttps://doi.org/10.1002/pros.20611openalex-snapshot

Antitumor activity of the histone deacetylase inhibitor MS‐275 in prostate cancer models

inferred← citeshttps://doi.org/10.1002/pros.20708openalex-snapshot

Neuroendocrine transdifferentiation induced by VPA is mediated by PPARγ activation and confers resistance to antiblastic therapy in prostate carcinoma

inferred← citeshttps://doi.org/10.1002/pros.21051openalex-snapshot

Induction of bicalutamide sensitivity in prostate cancer cells by an epigenetic Purα‐mediated decrease in androgen receptor levels

inferred← citeshttps://doi.org/10.1002/slct.201500038openalex-snapshot

Superparamagnetic Copper Ferrite Nanoparticles Catalyzed One Step Regioselective Synthesis of Dibenzodiazepinones via Ligand and Base Free Ullmann Type Coupling Reaction

inferred← citeshttps://doi.org/10.1007/1-4020-5466-1_17openalex-snapshot

Chromatin-Associated Regulation Of Hiv-1 Transcription

inferred← citeshttps://doi.org/10.1007/128_2011_302openalex-snapshot

ABPP Methodology: Introduction and Overview

inferred← citeshttps://doi.org/10.1007/7355_2006_007openalex-snapshot

HDAC Inhibition in Cancer Therapy: An Increasingly Intriguing Tale of Chemistry, Biology and Clinical Benefit

inferred← citeshttps://doi.org/10.1007/978-0-387-68969-2_16openalex-snapshot

Defective Apoptosis Underlies Chemoresistance in Ovarian Cancer

inferred← citeshttps://doi.org/10.1007/978-0-387-69057-5openalex-snapshot

The cancer degradome : proteases and cancer biology

inferred← citeshttps://doi.org/10.1007/978-0-387-69057-5_7openalex-snapshot

Activity-Based Imaging and Biochemical Profiling Tools for Analysis of the Cancer Degradome

inferred← citeshttps://doi.org/10.1007/978-1-0716-2788-4_11openalex-snapshot

Evaluation of Small-Molecule HDAC Inhibitors Through In Vitro and In Cellulo Approaches

inferred← citeshttps://doi.org/10.1007/978-1-4020-6554-5_4openalex-snapshot

Apoptotic Pathways in Tumor Progression and Therapy

inferred← citeshttps://doi.org/10.1007/978-1-4419-0477-5_14openalex-snapshot

The Future of Discoveries in Breast and Reproductive Cancers: The Genome and Epigenetics

inferred← citeshttps://doi.org/10.1007/978-1-4419-0639-7_13openalex-snapshot

Contributions of Tumor Suppressors to the Epigenetic Regulation of Aging Cells

inferred← citeshttps://doi.org/10.1007/978-1-4419-7107-4_37openalex-snapshot

Viral Hepatitis B

inferred← citeshttps://doi.org/10.1007/978-1-4419-9967-2_14openalex-snapshot

Epigenetic Targeting Therapies to Overcome Chemotherapy Resistance

inferred← citeshttps://doi.org/10.1007/978-1-4614-0730-0openalex-snapshot

Cell Signaling & Molecular Targets in Cancer

inferred← citeshttps://doi.org/10.1007/978-1-4614-0730-0_5openalex-snapshot

Signalling Molecules as Selective Targets for Therapeutic Strategies in Multiple Myeloma

inferred← citeshttps://doi.org/10.1007/978-1-4614-4666-8_14openalex-snapshot

Epigenetic Regulation of Myeloma Within Its Bone Marrow Microenvironment

inferred← citeshttps://doi.org/10.1007/978-1-4614-4756-6_11openalex-snapshot

Transcriptional Pathways and Potential Therapeutic Targets in the Regulation of Ncx1 Expression in Cardiac Hypertrophy and Failure

inferred← citeshttps://doi.org/10.1007/978-1-4614-6176-0_2openalex-snapshot

Update on Clinical Trials: Genetic Targets in Breast Cancer

inferred← citeshttps://doi.org/10.1007/978-1-4614-8039-6_16openalex-snapshot

Therapeutic Significance of Chromatin Remodeling Complexes in Cancer

inferred← citeshttps://doi.org/10.1007/978-1-4614-8039-6_4openalex-snapshot

Epigenetic Mechanisms of Cancer Metastasis

inferred← citeshttps://doi.org/10.1007/978-1-4939-0706-9_17openalex-snapshot

Combination Therapy for Cancer: Phototherapy and HDAC Inhibition

inferred← citeshttps://doi.org/10.1007/978-1-4939-0706-9_2openalex-snapshot

Role of Epigenetics in Neural Differentiation: Implications for Health and Disease

inferred← citeshttps://doi.org/10.1007/978-1-4939-1176-9_20openalex-snapshot

Epigenetics in Castration Resistant Prostate Cancer

inferred← citeshttps://doi.org/10.1007/978-1-4939-1393-0_21openalex-snapshot

AML: Deacetylases

inferred← citeshttps://doi.org/10.1007/978-1-4939-1804-1_25openalex-snapshot

Use of Epigenetic Modulators as a Powerful Adjuvant for Breast Cancer Therapies

inferred← citeshttps://doi.org/10.1007/978-1-4939-8751-1_4openalex-snapshot

Epigenome-Based Precision Medicine in Lung Cancer

inferred← citeshttps://doi.org/10.1007/978-1-59745-274-8_13openalex-snapshot

Do Histone Deacetylase Inhibitors Target Cell Cycle Checkpoints that Monitor Heterochromatin Structure?

inferred← citeshttps://doi.org/10.1007/978-1-59745-337-0_5openalex-snapshot

The Cancer Epigenome

inferred← citeshttps://doi.org/10.1007/978-1-59745-458-2_40openalex-snapshot

Small Molecule Inhibitors

inferred← citeshttps://doi.org/10.1007/978-1-59745-564-0_24openalex-snapshot

Histone Deacetylase Inhibitors in Multiple Myeloma

inferred← citeshttps://doi.org/10.1007/978-1-60761-433-3_8openalex-snapshot

Epigenetic Biomarkers in Melanoma

inferred← citeshttps://doi.org/10.1007/978-1-60761-860-7_8openalex-snapshot

Epigenetic Identity in Cancer Stem Cells

inferred← citeshttps://doi.org/10.1007/978-1-60761-980-2_14openalex-snapshot

Transcriptional Modulation Using Histone Deacetylase Inhibitors for Cancer Immunotherapy

inferred← citeshttps://doi.org/10.1007/978-1-61779-246-5_9openalex-snapshot

Cancer Stem Cells in Ovarian Cancer

inferred← citeshttps://doi.org/10.1007/978-1-61779-316-5_22openalex-snapshot

Inhibition of Histone Deacetylases

inferred← citeshttps://doi.org/10.1007/978-1-62703-170-7_16openalex-snapshot

Current Epigenetic Therapy for T-Cell Lymphoma

inferred← citeshttps://doi.org/10.1007/978-3-030-24424-8_5openalex-snapshot

Resistance to Histone Deacetylase Inhibitors in the Treatment of Lymphoma

inferred← citeshttps://doi.org/10.1007/978-3-030-39855-2_18openalex-snapshot

Combination Cancer Chemoprevention by Targeting the Epigenome

inferred← citeshttps://doi.org/10.1007/978-3-030-47189-7_1openalex-snapshot

Neuregulin Signaling in the Tumor Microenvironment

inferred← citeshttps://doi.org/10.1007/978-3-030-74028-3_11openalex-snapshot

Ultimate Precision: Targeting Cancer But Not Normal Self-Replication

inferred← citeshttps://doi.org/10.1007/978-3-031-04998-9_3openalex-snapshot

Polypharmacology in Clinical Applications—Anticancer Polypharmacology

inferred← citeshttps://doi.org/10.1007/978-3-031-52860-6_13openalex-snapshot

Emerging Therapeutic Approaches in Drug-Resistant Breast Cancer

inferred← citeshttps://doi.org/10.1007/978-3-319-24951-3_6openalex-snapshot

Epigenesis in Colorectal Cancer: A Lethal Change in the Cell

inferred← citeshttps://doi.org/10.1007/978-3-319-24951-3_7openalex-snapshot

Epigenetics and Angiogenesis in Cancer

inferred← citeshttps://doi.org/10.1007/978-3-319-53560-9_15openalex-snapshot

Standard Chemotherapy Options and Clinical Trials of Novel Agents for Mesothelioma

inferred← citeshttps://doi.org/10.1007/978-3-319-61872-2_5openalex-snapshot

Treatment of Patients in First or Second Relapse

inferred← citeshttps://doi.org/10.1007/978-3-642-12780-9_20openalex-snapshot

New Agents for Patients with Hodgkin Lymphoma

inferred← citeshttps://doi.org/10.1007/978-3-642-16483-5_1948openalex-snapshot

Epigenetic Therapy

inferred← citeshttps://doi.org/10.1007/978-3-642-16483-5_2752openalex-snapshot

Histone Deacetylases

inferred← citeshttps://doi.org/10.1007/978-3-642-16483-5_5327openalex-snapshot

Sirtuins

inferred← citeshttps://doi.org/10.1007/978-3-642-16483-5_6148openalex-snapshot

Valproic Acid

inferred← citeshttps://doi.org/10.1007/978-3-642-21631-2_3openalex-snapshot

Deacetylation of Nonhistone Proteins by HDACs and the Implications in Cancer

inferred← citeshttps://doi.org/10.1007/978-3-642-27841-9_1948-2openalex-snapshot

Epigenetic Therapy

inferred← citeshttps://doi.org/10.1007/978-3-642-27841-9_6148-2openalex-snapshot

Valproic Acid

inferred← citeshttps://doi.org/10.1007/978-3-642-36827-1_9openalex-snapshot

Nutrition, Histone Epigenetic Marks, and Disease

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