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Protein drug stability: a formulation challenge

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Oxidative renaturation of lysozyme at high concentrations
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II. Electrostatic effect in the aggregation of heat-denatured RNase A and implications for protein additive design
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Protection of Bovine Serum Albumin from Aggregation by Tween 80
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Immunogenicity of interferon-? in multiple sclerosis patients: Influence of preparation, dosage, dose frequency, and route of administration
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A new mechanism for decreasing aggregation of recombinant human interferon‐γ by a surfactant: Slowed dissolution of lyophilized formulations in a solution containing 0.03% polysorbate 20
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Challenges in the development of high protein concentration formulations
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Probing Structural Changes of Proteins Incorporated into Water-in-Oil Emulsions
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Cyclodextrins as Protein Folding Aids
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Conformation and Fibrillogenesis of Alzheimer Aβ Peptides with Selected Substitution of Charged Residues
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A 50th Order Reaction Predicted and Observed for Sickle Hemoglobin Nucleation
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Common core structure of amyloid fibrils by synchrotron X-ray diffraction 1 1Edited by F. E. Cohen
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A simple way to measure protein refolding rates in water
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Challenges in the Development of High Protein Concentration Formulations
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Coping with Stress
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Cyclodextrins in Pharmacy
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Soluble, fatty acid acylated insulins bind to albumin and show protracted action in pigs
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Dityrosine as a product of oxidative stress and fluorescent probe
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Biodegradable mucoadhesive particulates for nasal and pulmonary antigen and DNA delivery
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In situ forming parenteral drug delivery systems: an overview
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Protein aggregation and its inhibition in biopharmaceutics
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Stressed-out B cells? Plasma-cell differentiation and the unfolded protein response
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Absorption enhancers in pulmonary protein delivery
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The role of branched polyesters and their modifications in the development of modern drug delivery vehicles
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Silent Prions Lying in Wait: A Two-hit Model of Prion/Amyloid Formation and Infection
inferredcites →https://doi.org/10.1016/j.jmb.2004.06.020openalex-snapshot
Modulation of S6 Fibrillation by Unfolding Rates and Gatekeeper Residues
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Prediction of the Absolute Aggregation Rates of Amyloidogenic Polypeptide Chains
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Phospholipid Catalysis of Diabetic Amyloid Assembly
inferredcites →https://doi.org/10.1016/j.sbi.2003.10.010openalex-snapshot
Pathological and functional amyloid formation orchestrated by the secretory pathway
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A trip to the ER: coping with stress
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Protein folding in the cell: reshaping the folding funnel
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Simulations of kinetically irreversible protein aggregate structure
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How Hofmeister ion interactions affect protein stability
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Association of acylated cationic decapeptides with dipalmitoylphosphatidylserine–dipalmitoylphosphatidylcholine lipid membranes
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Biophysical mechanisms of phospholipase A2 activation and their use in liposome‐based drug delivery
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Mutations that Reduce Aggregation of the Alzheimer's Aβ42 Peptide: an Unbiased Search for the Sequence Determinants of Aβ Amyloidogenesis
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Protein Destabilization at Low Temperatures
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[15] Inhibition of aggregation side reactions during in vitro protein folding
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[17] Analysis of protein aggregation kinetics
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Clinical importance of neutralising antibodies against interferon beta in patients with relapsing-remitting multiple sclerosis
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Peginterferon alfa-2a: A review of approved and investigational uses
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Nanotechnological approaches for the delivery of macromolecules
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Introduction and overview of peptide and protein pegylation
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Polyethylene glycol–superoxide dismutase, a conjugate in search of exploitation
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Designing drugs to stop the formation of prion aggregates and other amyloids
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Lyophilization and development of solid protein pharmaceuticals
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Parenteral water/oil emulsions containing hydrophilic compounds with enhanced in vivo retention: formulation, rheological characterisation and study of in vivo fate using whole body gamma-scintigraphy
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Nanostructured lipid matrices for improved microencapsulation of drugs
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Instability, stabilization, and formulation of liquid protein pharmaceuticals
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Influence of cyclodextrins on the stability of the peptide salmon calcitonin in aqueous solution
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Kinetic degradation study of insulin complexed with methyl-beta cyclodextrin. Confirmation of complexation with electrospray mass spectrometry and 1H NMR
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Smart and genetically engineered biomaterials and drug delivery systems
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Hydrogels in pharmaceutical formulations
inferredcites →https://doi.org/10.1016/s0939-6411(98)00004-6openalex-snapshot
Freeze-drying of bioproducts: putting principles into practice
inferredcites →https://doi.org/10.1016/s0958-1669(97)80159-0openalex-snapshot
Influence of excluded volume upon macromolecular structure and associations in ‘crowded” media
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Macromolecular crowding: an important but neglected aspect of the intracellular environment
inferredcites →https://doi.org/10.1016/s0968-0004(99)01445-0openalex-snapshot
Protein misfolding, evolution and disease
inferredcites →https://doi.org/10.1016/s1359-0278(98)00002-9openalex-snapshot
Protein aggregation: folding aggregates, inclusion bodies and amyloid
inferredcites →https://doi.org/10.1016/s1381-1177(98)00105-2openalex-snapshot
α-Chymotrypsin stability in aqueous-acetonitrile mixtures: is the native enzyme thermodynamically or kinetically stable under low water conditions?
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Water as a plasticizer: physico-chemical aspects of low-moisture polymeric systems
inferredcites →https://doi.org/10.1017/s0958344004001028openalex-snapshot
Putting principles into practice
inferredcites →https://doi.org/10.1021/bi00069a001openalex-snapshot
The carboxy terminus of the .beta. amyloid protein is critical for the seeding of amyloid formation: Implications for the pathogenesis of Alzheimer's disease
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Probing the Mechanism of Insulin Fibril Formation with Insulin Mutants
inferredcites →https://doi.org/10.1021/bi012006mopenalex-snapshot
Aggregation of Granulocyte Colony Stimulating Factor under Physiological Conditions: Characterization and Thermodynamic Inhibition
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Protein Hydration, Thermodynamic Binding, and Preferential Hydration
inferredcites →https://doi.org/10.1021/bi036034bopenalex-snapshot
Evidence for an Intermediate in Tau Filament Formation
inferredcites →https://doi.org/10.1021/bi048564topenalex-snapshot
Role for the α-Helix in Aberrant Protein Aggregation
inferredcites →https://doi.org/10.1021/bi0485880openalex-snapshot
Stereospecific Amyloid-like Fibril Formation by a Peptide Fragment of β2-Microglobulin
inferredcites →https://doi.org/10.1021/bi048846topenalex-snapshot
Rapid Assembly of Amyloid-β Peptide at a Liquid/Liquid Interface Produces Unstable β-Sheet Fibers
inferredcites →https://doi.org/10.1021/bi049002copenalex-snapshot
Formation of Amyloid Fibers Triggered by Phosphatidylserine-Containing Membranes
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Structural Basis of Protein Kinetic Stability: Resistance to Sodium Dodecyl Sulfate Suggests a Central Role for Rigidity and a Bias Toward β-Sheet Structure
inferredcites →https://doi.org/10.1021/j100188a023openalex-snapshot
Correlation effects and electron delocalization in nonalternant hydrocarbon .pi. compounds
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Theory for the aggregation of proteins and copolymers
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Effect of cyclodextrins on the thermal stability of globular proteins
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A Simple Method for Improving Protein Solubility and Long-Term Stability
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Formation of intermolecular .beta.-sheet structure during heat denaturation of ovalbumin
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Potent Derivatives of Glucagon-like Peptide-1 with Pharmacokinetic Properties Suitable for Once Daily Administration
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Toward Understanding Insulin Fibrillation
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Effects of Tween 80 and Sucrose on Acute Short-Term Stability and Long-Term Storage at −20 C of a Recombinant Hemoglobin
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Palmitoyl Derivatives of Interferon α: Potential for Cutaneous Delivery
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Inverse Relationship of Protein Concentration and Aggregation
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Preparation and Characterization of Mono-PEGylated Epidermal Growth Factor: Evaluation of in Vitro Biologic Activity
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Preparation, Purification, and Characterization of a Reversibly Lipidized Desmopressin with Potentiated Anti-Diuretic Activity
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Aggregates Formed During Storage of β-Galactosidase in Solution and in the Freeze-Dried State
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Moisture-Induced Aggregation of Lyophilized Insulin
inferredcites →https://doi.org/10.1023/a:1025771421906openalex-snapshot
Physical Stability of Proteins in Aqueous Solution: Mechanism and Driving Forces in Nonnative Protein Aggregation
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Micelle-Associated Protein in Epoetin Formulations: A Risk Factor for Immunogenicity?
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Structure-Immunogenicity Relationships of Therapeutic Proteins
inferredcites →https://doi.org/10.1023/b:pham.0000033016.36825.2copenalex-snapshot
Mishandling of the Therapeutic Peptide Glucagon Generates Cytotoxic Amyloidogenic Fibrils
inferredcites →https://doi.org/10.1038/nature01891openalex-snapshot
Rationalization of the effects of mutations on peptide andprotein aggregation rates
inferredcites →https://doi.org/10.1038/nature02261openalex-snapshot
Protein folding and misfolding
inferredcites →https://doi.org/10.1038/nature03192openalex-snapshot
Chemical space and biology
inferredcites →https://doi.org/10.1038/nbt0394-253openalex-snapshot
Long–Term Stabilization of Biologicals
inferredcites →https://doi.org/10.1038/nbt1012openalex-snapshot
Prediction of sequence-dependent and mutational effects on the aggregation of peptides and proteins
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Recombinant protein therapeutics—success rates, market trends and values to 2010
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Kinetic partitioning of protein folding and aggregation
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Albumin binding of insulins acylated with fatty acids: characterization of the ligand-protein interaction and correlation between binding affinity and timing of the insulin effect in vivo
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Influence of cyclodextrin ring substituents on folding‐related aggregation of bovine carbonic anhydrase
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Pure Red-Cell Aplasia and Antierythropoietin Antibodies in Patients Treated with Recombinant Erythropoietin
inferredcites →https://doi.org/10.1073/pnas.042681399openalex-snapshot
Amyloid fibers are water-filled nanotubes
inferredcites →https://doi.org/10.1073/pnas.160086297openalex-snapshot
Designed protein tetramer zipped together with a hydrophobic Alzheimer homology: A structural clue to amyloid assembly
inferredcites →https://doi.org/10.1073/pnas.182276099openalex-snapshot
Huntington's disease age-of-onset linked to polyglutamine aggregation nucleation
inferredcites →https://doi.org/10.1073/pnas.95.24.14142openalex-snapshot
A transient expansion of the native state precedes aggregation of recombinant human interferon-γ
inferredcites →https://doi.org/10.1073/pnas.96.21.11746openalex-snapshot
Salt-induced detour through compact regions of the protein folding landscape
inferredcites →https://doi.org/10.1073/pnas.96.6.2608openalex-snapshot
Protein folding at the air–water interface studied with x-ray reflectivity
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Arrest of -Amyloid Fibril Formation by a Pentapeptide Ligand
inferredcites →https://doi.org/10.1074/jbc.271.7.3478openalex-snapshot
Artificial Chaperone-assisted Refolding of Carbonic Anhydrase B
inferredcites →https://doi.org/10.1074/jbc.m212618200openalex-snapshot
Kinetic Stabilization of Bacillus licheniformis α-Amylase through Introduction of Hydrophobic Residues at the Surface
inferredcites →https://doi.org/10.1074/jbc.m308231200openalex-snapshot
Rapid Anionic Micelle-mediated α-Synuclein Fibrillization in Vitro
inferredcites →https://doi.org/10.1074/jbc.m311300200openalex-snapshot
Seeding Specificity in Amyloid Growth Induced by Heterologous Fibrils
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Prevention of Alzheimer's Disease-associated Aβ Aggregation by Rationally Designed Nonpeptidic β-Sheet Ligands
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Inhibition of Heparin-induced Tau Filament Formation by Phenothiazines, Polyphenols, and Porphyrins
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Direct Measurement of the Thermodynamic Parameters of Amyloid Formation by Isothermal Titration Calorimetry
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Special RECOMB’99 Issue
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Lattice Simulations of Aggregation Funnels for Protein Folding
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Site-specific mutagenesis in a homogeneous polyglutamine tract: application to spinocerebellar ataxin-3
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Structural background of cyclodextrin-protein interactions
inferredcites →https://doi.org/10.1110/ps.0202702openalex-snapshot
Structural basis for cyclodextrins' suppression of human growth hormone aggregation
inferredcites →https://doi.org/10.1110/ps.04707004openalex-snapshot
Observation of sequence specificity in the seeding of protein amyloid fibrils
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Renaturation of Escherichia coli Tryptophanase after Exposure to 8 M Urea
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Potential Use of Maltosyl‐β‐cyclodextrin for Inhibition of Insulin Self‐association in Aqueous Solution
inferredcites →https://doi.org/10.1126/science.1063522openalex-snapshot
Kinetic Stabilization of the α-Synuclein Protofibril by a Dopamine-α-Synuclein Adduct
inferredcites →https://doi.org/10.1126/science.1067484openalex-snapshot
Role of Escherichia coli Curli Operons in Directing Amyloid Fiber Formation
inferredcites →https://doi.org/10.1126/science.1101262openalex-snapshot
Harnessing Chaperones to Generate Small-Molecule Inhibitors of Amyloid ß Aggregation
inferredcites →https://doi.org/10.1126/science.1105850openalex-snapshot
Self-Propagating, Molecular-Level Polymorphism in Alzheimer's ß-Amyloid Fibrils
inferredcites →https://doi.org/10.1142/p124openalex-snapshot
Modified Cyclodextrins
inferredcites →https://doi.org/10.1146/annurev.biochem.66.1.385openalex-snapshot
MODELS OF AMYLOID SEEDING IN ALZHEIMER'S DISEASE AND SCRAPIE: Mechanistic Truths and Physiological Consequences of the Time-Dependent Solubility of Amyloid Proteins
inferredcites →https://doi.org/10.1146/annurev.bioeng.4.092801.094202openalex-snapshot
Peptide Aggregation in Neurodegenerative Disease
inferredcites →https://doi.org/10.1201/b11687-51openalex-snapshot
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inferredcites →https://doi.org/10.2174/1389201023378229openalex-snapshot
The Stability Factor: Importance in Formulation Development
inferredcites →https://doi.org/10.2174/1389557023405873openalex-snapshot
Liposomes for Intravenous Drug Targeting: Design and Applications
inferredcites →https://doi.org/10.2337/diacare.13.9.923openalex-snapshot
Monomeric Insulins and Their Experimental and Clinical Implications
inferredcites →https://doi.org/10.3109/10611869308996093openalex-snapshot
Minimization of Shaking-induced Formation of Insoluble Aggregates of Insulin by Cyclodextrins
inferredcites →https://doi.org/10.4049/jimmunol.173.8.5258openalex-snapshot
Allergy Vaccine Engineering: Epitope Modulation of Recombinant Bet v 1 Reduces IgE Binding but Retains Protein Folding Pattern for Induction of Protective Blocking-Antibody Responses
inferredcites →https://doi.org/10.5860/choice.34-5097openalex-snapshot
Comprehensive supramolecular chemistry

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Sub‐50 nm Nanoparticles with Biomimetic Surfaces to Sequentially Overcome the Mucosal Diffusion Barrier and the Epithelial Absorption Barrier
inferred← citeshttps://doi.org/10.1002/adfm.201807909openalex-snapshot
Mechanically Activated Microcapsules for “On‐Demand” Drug Delivery in Dynamically Loaded Musculoskeletal Tissues
inferred← citeshttps://doi.org/10.1002/adfm.202003579openalex-snapshot
Nanoengineered Light‐Activatable Polybubbles for On‐Demand Therapeutic Delivery
inferred← citeshttps://doi.org/10.1002/adfm.202406878openalex-snapshot
An Ultrahydrating Polymer that Protects Protein Therapeutics and RNA‐Lipid Nanoparticles Against Freezing, Heat and Lyophilization Stress
inferred← citeshttps://doi.org/10.1002/adhm.201200419openalex-snapshot
Efficient Delivery of p53 and Cytochrome C by Supramolecular Assembly of a Dendritic Multi‐Domain Delivery System
inferred← citeshttps://doi.org/10.1002/adhm.201500334openalex-snapshot
Covalent Incorporation of Trehalose within Hydrogels for Enhanced Long‐Term Functional Stability and Controlled Release of Biomacromolecules
inferred← citeshttps://doi.org/10.1002/adhm.201800950openalex-snapshot
Metal‐Organic Framework Encapsulation Preserves the Bioactivity of Protein Therapeutics
inferred← citeshttps://doi.org/10.1002/adhm.202401793openalex-snapshot
Develop Targeted Protein Drug Carriers through a High‐Throughput Screening Platform and Rational Design
inferred← citeshttps://doi.org/10.1002/adhm.71550openalex-snapshot
Enhancing Bioavailability of Ultra‐High Concentration Antibody Formulations Using Ionic Liquids
inferred← citeshttps://doi.org/10.1002/adma.201300951openalex-snapshot
In Situ Self‐Folding Assembly of a Multi‐Walled Hydrogel Tube for Uniaxial Sustained Molecular Release
inferred← citeshttps://doi.org/10.1002/adma.201701255openalex-snapshot
Nanostructured Mineral Coatings Stabilize Proteins for Therapeutic Delivery
inferred← citeshttps://doi.org/10.1002/adma.201707196openalex-snapshot
3D Jet Writing: Functional Microtissues Based on Tessellated Scaffold Architectures
inferred← citeshttps://doi.org/10.1002/adma.201806898openalex-snapshot
Emerging Trends in Information‐Driven Engineering of Complex Biological Systems
inferred← citeshttps://doi.org/10.1002/adma.201902791openalex-snapshot
Rational Design of Nanocarriers for Intracellular Protein Delivery
inferred← citeshttps://doi.org/10.1002/adma.202403116openalex-snapshot
Innovative Formulation Platform: Paving the Way for Superior Protein Therapeutics with Enhanced Efficacy and Broadened Applications
inferred← citeshttps://doi.org/10.1002/adma.202412154openalex-snapshot
LysSYL‐Loaded pH‐Switchable Self‐Assembling Peptide Hydrogels Promote Methicillin‐Resistant Staphylococcus Aureus Elimination and Wound Healing
inferred← citeshttps://doi.org/10.1002/adma.74355openalex-snapshot
A Bifunctional Artificial Antibody for Universal Antimicrobial Therapy
inferred← citeshttps://doi.org/10.1002/adtp.201900116openalex-snapshot
Recent Advances in the Transdermal Delivery of Protein Therapeutics with a Combinatorial System of Chemical Adjuvants and Physical Penetration Enhancements
inferred← citeshttps://doi.org/10.1002/adtp.202200102openalex-snapshot
Stable High‐Concentration Monoclonal Antibody Formulations Enabled by an Amphiphilic Copolymer Excipient
inferred← citeshttps://doi.org/10.1002/ange.201005740openalex-snapshot
Delivery of Intact Transcription Factor by Using Self‐Assembled Supramolecular Nanoparticles
inferred← citeshttps://doi.org/10.1002/ange.201302181openalex-snapshot
Mix to Validate: A Facile, Reversible PEGylation for Fast Screening of Potential Therapeutic Proteins In Vivo
inferred← citeshttps://doi.org/10.1002/ange.201509183openalex-snapshot
Polymeric Nanoparticles Amenable to Simultaneous Installation of Exterior Targeting and Interior Therapeutic Proteins
inferred← citeshttps://doi.org/10.1002/ange.201807298openalex-snapshot
Oral aktive Peptide: Gibt es ein Patentrezept?
inferred← citeshttps://doi.org/10.1002/ange.202309582openalex-snapshot
Design of an Oxygen‐Tolerant Photo‐RAFT System for Protein‐Polymer Conjugation Achieving High Bioactivity
inferred← citeshttps://doi.org/10.1002/anie.201005740openalex-snapshot
Delivery of Intact Transcription Factor by Using Self‐Assembled Supramolecular Nanoparticles
inferred← citeshttps://doi.org/10.1002/anie.201302181openalex-snapshot
Mix to Validate: A Facile, Reversible PEGylation for Fast Screening of Potential Therapeutic Proteins In Vivo
inferred← citeshttps://doi.org/10.1002/anie.201509183openalex-snapshot
Polymeric Nanoparticles Amenable to Simultaneous Installation of Exterior Targeting and Interior Therapeutic Proteins
inferred← citeshttps://doi.org/10.1002/anie.201807298openalex-snapshot
Orally Active Peptides: Is There a Magic Bullet?
inferred← citeshttps://doi.org/10.1002/anie.202309582openalex-snapshot
Design of an Oxygen‐Tolerant Photo‐RAFT System for Protein‐Polymer Conjugation Achieving High Bioactivity
inferred← citeshttps://doi.org/10.1002/app.40514openalex-snapshot
In vitro evaluation of spray‐dried chitosan microspheres crosslinked with pyromellitic dianhydride for oral colon‐specific delivery of protein drugs
inferred← citeshttps://doi.org/10.1002/app.49550openalex-snapshot
Encapsulation and delivery of protein from within poly(sulfobetaine) hydrogel beads
inferred← citeshttps://doi.org/10.1002/asia.201500630openalex-snapshot
Calcium Carbonate Mineralized Nanoparticles as an Intracellular Transporter of Cytochrome c for Cancer Therapy
inferred← citeshttps://doi.org/10.1002/biot.201400858openalex-snapshot
A multiscale view of therapeutic protein aggregation: A colloid science perspective
inferred← citeshttps://doi.org/10.1002/biot.70023openalex-snapshot
Impact of Eco‐Friendly Surfactant Structure and Class on Enveloped Virus Inactivation
inferred← citeshttps://doi.org/10.1002/bip.20598openalex-snapshot
pH‐dependent aggregation of cutinase is efficiently suppressed by 1,8‐ANS
inferred← citeshttps://doi.org/10.1002/bip.21011openalex-snapshot
Characterization of dry globular proteins and protein fibrils by synchrotron radiation vacuum UV circular dichroism
inferred← citeshttps://doi.org/10.1002/bip.21323openalex-snapshot
Thermal stability and conformational structure of salmon calcitonin in the solid and liquid states
inferred← citeshttps://doi.org/10.1002/bip.21677openalex-snapshot
Pluronic F68 enhanced the conformational stability of salmon calcitonin in both aqueous solution and lyophilized solid form
inferred← citeshttps://doi.org/10.1002/bip.22767openalex-snapshot
Approaches to the stabilization of bioactive epitopes by grafting and peptide cyclization
inferred← citeshttps://doi.org/10.1002/bit.20933openalex-snapshot
Engineering of protein thermodynamic, kinetic, and colloidal stability: Chemical Glycosylation with monofunctionally activated glycans
inferred← citeshttps://doi.org/10.1002/bit.22014openalex-snapshot
Stabilization of α‐chymotrypsin upon PEGylation correlates with reduced structural dynamics
inferred← citeshttps://doi.org/10.1002/bit.22017openalex-snapshot
Determination of protein aggregation with differential mobility analysis: Application to IgG antibody
inferred← citeshttps://doi.org/10.1002/bit.22983openalex-snapshot
Hydrophobic salts markedly diminish viscosity of concentrated protein solutions
inferred← citeshttps://doi.org/10.1002/bkcs.11594openalex-snapshot
Enhanced Chemical Stability of Hirsutenone Incorporated into a Nanostructured Lipid Carrier Formulation Containing Antioxidants
inferred← citeshttps://doi.org/10.1002/bkcs.12664openalex-snapshot
Application of isothermal chemical denaturation to early‐stage formulation development of fibrinogen
inferred← citeshttps://doi.org/10.1002/btm2.10041openalex-snapshot
Peptide‐based supramolecular hydrogels for delivery of biologics
inferred← citeshttps://doi.org/10.1002/btm2.10053openalex-snapshot
Picoliter‐volume inkjet printing into planar microdevice reservoirs for low‐waste, high‐capacity drug loading
inferred← citeshttps://doi.org/10.1002/btm2.10121openalex-snapshot
Device design methodology and formulation of a protein therapeutic for sustained release intraocular delivery
inferred← citeshttps://doi.org/10.1002/btm2.10163openalex-snapshot
Employing drug delivery strategies to create safe and effective pharmaceuticals for COVID ‐19
inferred← citeshttps://doi.org/10.1002/btm2.10479openalex-snapshot
Implantable device with magnetically rotating disk for needle‐free administrations of emergency drug
inferred← citeshttps://doi.org/10.1002/btm2.10693openalex-snapshot
Cowpea mosaic virus intratumoral immunotherapy maintains stability and efficacy after long‐term storage
inferred← citeshttps://doi.org/10.1002/btpr.563openalex-snapshot
Effects of arginine on heat‐induced aggregation of concentrated protein solutions
inferred← citeshttps://doi.org/10.1002/cbic.201800754openalex-snapshot
Natural Voltage‐Gated Sodium Channel Ligands: Biosynthesis and Biology
inferred← citeshttps://doi.org/10.1002/chem.201602298openalex-snapshot
Site‐Selective Disulfide Modification of Proteins: Expanding Diversity beyond the Proteome
inferred← citeshttps://doi.org/10.1002/cphc.202000761openalex-snapshot
Implication of Threonine‐Based Ionic Liquids on the Structural Stability, Binding and Activity of Cytochrome c
inferred← citeshttps://doi.org/10.1002/ejoc.201600402openalex-snapshot
Cyclisation of Disulfide‐Rich Conotoxins in Drug Design Applications
inferred← citeshttps://doi.org/10.1002/ijch.201100045openalex-snapshot
Cucurbituril: At the Interface of Small Molecule Host–Guest Chemistry and Dynamic Aggregates
inferred← citeshttps://doi.org/10.1002/jbm.a.30991openalex-snapshot
Drug release from pH‐responsive thermogelling pentablock copolymers
inferred← citeshttps://doi.org/10.1002/jbm.a.35626openalex-snapshot
Integrin‐specific hydrogels functionalized with VEGF for vascularization and bone regeneration of critical‐size bone defects
inferred← citeshttps://doi.org/10.1002/jbm.a.36423openalex-snapshot
Optimization of PLGA formulation containing protein or peptide‐based antigen: Recent advances
inferred← citeshttps://doi.org/10.1002/jcc.27249openalex-snapshot
Predicting the effects of mutations on protein solubility using graph convolution network and protein language model representation
inferred← citeshttps://doi.org/10.1002/jev2.12155openalex-snapshot
Cell trafficking and regulation of osteoblastogenesis by extracellular vesicle associated bone morphogenetic protein 2
inferred← citeshttps://doi.org/10.1002/jgm.1297openalex-snapshot
Gene induction for the treatment of methylmalonic aciduria
inferred← citeshttps://doi.org/10.1002/jmr.2944openalex-snapshot
Zwitterionic polymers in drug delivery: A review
inferred← citeshttps://doi.org/10.1002/jmr.2980openalex-snapshot
In silico characterization of fructosyl peptide oxidase properties from Eupenicillium terrenum
inferred← citeshttps://doi.org/10.1002/jps.20715openalex-snapshot
Effects of Cyclodextrins on Chemically and Thermally Induced Unfolding and Aggregation of Lysozyme and Basic Fibroblast Growth Factor
inferred← citeshttps://doi.org/10.1002/jps.20796openalex-snapshot
Effects of Solutes on Empirical Phase Diagrams of Human Fibroblast Growth Factor 1
inferred← citeshttps://doi.org/10.1002/jps.20966openalex-snapshot
The LC/MS Analysis of Glycation of IGG Molecules in Sucrose Containing Formulations
inferred← citeshttps://doi.org/10.1002/jps.21199openalex-snapshot
High Concentration Formulations of Recombinant Human Interleukin-1 Receptor Antagonist: I. Physical Characterization
inferred← citeshttps://doi.org/10.1002/jps.21269openalex-snapshot
The Complex Inter-Relationships Between Protein Flexibility and Stability
inferred← citeshttps://doi.org/10.1002/jps.21504openalex-snapshot
Effects of glycosylation on the stability of protein pharmaceuticals
inferred← citeshttps://doi.org/10.1002/jps.21749openalex-snapshot
The effect of sucrose hydrolysis on the stability of protein therapeutics during accelerated formulation studies
inferred← citeshttps://doi.org/10.1002/jps.21931openalex-snapshot
Inhibition of Agitation‐Induced Aggregation of an IgG‐Antibody by Hydroxypropyl‐β‐Cyclodextrin
inferred← citeshttps://doi.org/10.1002/jps.22562openalex-snapshot
Investigation of PEG Crystallization in Frozen and Freeze‐Dried PEGylated Recombinant Human Growth Hormone–Sucrose Systems: Implications on Storage Stability
inferred← citeshttps://doi.org/10.1002/jps.22808openalex-snapshot
Simultaneous Detection and Analysis of Protein Aggregation and Protein Unfolding by size Exclusion Chromatography with Post Column Addition of the Fluorescent Dye BisANS
inferred← citeshttps://doi.org/10.1002/jps.23118openalex-snapshot
Selective Domain Stabilization as a Strategy to Reduce Human Serum Albumin–Human Granulocyte Colony Stimulating Factor Aggregation Rate
inferred← citeshttps://doi.org/10.1002/jps.23219openalex-snapshot
Native-State Solubility and Transfer Free Energy as Predictive Tools for Selecting Excipients to Include in Protein Formulation Development Studies
inferred← citeshttps://doi.org/10.1002/jps.23256openalex-snapshot
Antibody nanoparticle dispersions formed with mixtures of crowding molecules retain activity and In Vivo bioavailability
inferred← citeshttps://doi.org/10.1002/jps.23729openalex-snapshot
Influence of Hydroxypropyl‐Beta‐Cyclodextrin on the Stability of Dilute and Highly Concentrated Immunoglobulin G Formulations
inferred← citeshttps://doi.org/10.1002/jps.23745openalex-snapshot
Fuzzy Logic-Based Expert System for Evaluating Cake Quality of Freeze-Dried Formulations
inferred← citeshttps://doi.org/10.1002/jps.23786openalex-snapshot
Unmasking Translucent Protein Particles by Improved Micro-Flow Imaging™ Algorithms
inferred← citeshttps://doi.org/10.1002/jps.24063openalex-snapshot
Arrhenius Time-Scaled Least Squares: A Simple, Robust Approach to Accelerated Stability Data Analysis for Bioproducts
inferred← citeshttps://doi.org/10.1002/jps.24121openalex-snapshot
The Induction of Prolonged Myelopoietic Effects in Monkeys by GW003, A Recombinant Human Granulocyte Colony-Stimulating Factor Genetically Fused to Recombinant Human Albumin
inferred← citeshttps://doi.org/10.1002/jps.24217openalex-snapshot
Noncovalent PEGylation of l-Asparaginase Using PEGylated Polyelectrolyte
inferred← citeshttps://doi.org/10.1002/jps.24279openalex-snapshot
Enzyme Dehydration Using Microglassification™ Preserves the Protein's Structure and Function
inferred← citeshttps://doi.org/10.1002/jps.24672openalex-snapshot
Influence of Tableting on the Conformation and Thermal Stability of Trypsin as a Model Protein
inferred← citeshttps://doi.org/10.1002/jsfa.13612openalex-snapshot
Evodiamine and its nano‐based approaches for enhanced cancer therapy: recent advances and challenges
inferred← citeshttps://doi.org/10.1002/mabi.200700051openalex-snapshot
Dendrimer Effects on Peptide and Protein Fibrillation
inferred← citeshttps://doi.org/10.1002/mabi.200800317openalex-snapshot
Injectable Microsphere/Hydrogel Combination Systems for Localized Protein Delivery
inferred← citeshttps://doi.org/10.1002/mabi.201100352openalex-snapshot
Injectable Hydrogel for Sustained Protein Release by Salt‐Induced Association of Hyaluronic Acid Nanogel
inferred← citeshttps://doi.org/10.1002/mabi.201500083openalex-snapshot
Cationic Polyrotaxanes as a Feasible Framework for the Intracellular Delivery and Sustainable Activity of Anionic Enzymes: A Comparison Study with Methacrylate-Based Polycations
inferred← citeshttps://doi.org/10.1002/pat.1338openalex-snapshot
Microencapsulation of protein‐loaded polysaccharide particles within poly(D,L‐lactic‐co‐glycolic acid) microspheres using S/O/W: characterization and release studies
inferred← citeshttps://doi.org/10.1002/pat.3569openalex-snapshot
Stable formulation of protein‐type drug in electrospun polymeric fiber followed by tableting and scaling‐up experiments
inferred← citeshttps://doi.org/10.1002/pen.26980openalex-snapshot
The preparation of melt electrospun fiber containing tandospirone for drug sustained release
inferred← citeshttps://doi.org/10.1002/pep2.24171openalex-snapshot
Targeting of peptide‐binding receptors on cancer cells with peptide‐drug conjugates
inferred← citeshttps://doi.org/10.1002/pro.309openalex-snapshot
Aggregation of a multidomain protein: A coagulation mechanism governs aggregation of a model IgG1 antibody under weak thermal stress
inferred← citeshttps://doi.org/10.1002/pro.3518openalex-snapshot
Isotonic concentrations of excipients control the dimerization rate of a therapeutic immunoglobulin G1 antibody during refrigerated storage based on their rank order of native‐state interaction
inferred← citeshttps://doi.org/10.1002/pro.4231openalex-snapshot
Protection by desiccation‐tolerance proteins probed at the residue level
inferred← citeshttps://doi.org/10.1002/pro.4288openalex-snapshot
Desiccation‐tolerance and globular proteins adsorb similar amounts of water
inferred← citeshttps://doi.org/10.1002/pro.4392openalex-snapshot
Impact of the PEG length and PEGylation site on the structural, thermodynamic, thermal, and proteolytic stability of mono‐PEGylated alpha‐1 antitrypsin
inferred← citeshttps://doi.org/10.1002/pro.4913openalex-snapshot
Protective roles of highly conserved motif 1 in tardigrade cytosolic‐abundant heat soluble protein in extreme environments
inferred← citeshttps://doi.org/10.1002/pro.70075openalex-snapshot
Understanding dry proteins and their protection with solid‐state hydrogen–deuterium exchange
inferred← citeshttps://doi.org/10.1002/pro.70494openalex-snapshot
Concentration‐dependent dimerization of staphylokinase variants with engineered surface charges
inferred← citeshttps://doi.org/10.1002/prot.23163openalex-snapshot
Prots: A fragment based protein thermo‐stability potential
inferred← citeshttps://doi.org/10.1002/psc.2727openalex-snapshot
Synthesis and evaluation of novel lipidated neuromedin U analogs with increased stability and effects on food intake
inferred← citeshttps://doi.org/10.1002/psc.70008openalex-snapshot
Preventing Protein Self‐Association Through Strategic Covalent Modification
inferred← citeshttps://doi.org/10.1002/slct.202302409openalex-snapshot
Synergistic Effect of Charged Amino Acids on the Stability and Fibril Formation of Lysozyme
inferred← citeshttps://doi.org/10.1002/slct.202506605openalex-snapshot
Bis(phenolate)–Titanium(IV) Catalysts for Efficient and Sustainable Direct Amide Bond Formation
inferred← citeshttps://doi.org/10.1002/smll.201500192openalex-snapshot
Superhydrophobic Surfaces as a Tool for the Fabrication of Hierarchical Spherical Polymeric Carriers
inferred← citeshttps://doi.org/10.1002/smll.201702323openalex-snapshot
Optimizing Multiplexed Detections of Diabetes Antibodies via Quantitative Microfluidic Droplet Array
inferred← citeshttps://doi.org/10.1002/smll.202305131openalex-snapshot
Ultrahigh Enzyme Loading Metal–Organic Frameworks for Deep Tissue Pancreatic Cancer Photoimmunotherapy
inferred← citeshttps://doi.org/10.1002/smll.202501787openalex-snapshot
Thermo‐pH‐Sensitive Polypeptides Boost Protein Drug's Tumor Permeation and Pharmacology
inferred← citeshttps://doi.org/10.1002/smtd.202001132openalex-snapshot
Co‐Delivery of Paclitaxel and shMCL‐1 by Folic Acid‐Modified Nonviral Vector to Overcome Cancer Chemotherapy Resistance
inferred← citeshttps://doi.org/10.1002/wnan.1516openalex-snapshot
Poly(lactic‐co‐glycolic acid) devices: Production and applications for sustained protein delivery
inferred← citeshttps://doi.org/10.1007/10_2019_119openalex-snapshot
Insights on the Formulation of Recombinant Proteins
inferred← citeshttps://doi.org/10.1007/978-1-0716-1450-1_4openalex-snapshot
Assessment of Therapeutic Antibody Developability by Combinations of In Vitro and In Silico Methods
inferred← citeshttps://doi.org/10.1007/978-1-4614-0554-2_20openalex-snapshot
Delivery of Peptides and Proteins via Long Acting Injections and Implants
inferred← citeshttps://doi.org/10.1007/978-1-4614-0554-2_5openalex-snapshot
Drugs for Long Acting Injections and Implants
inferred← citeshttps://doi.org/10.1007/978-1-4614-7876-8_23openalex-snapshot
The EPR Effect in Cancer Therapy
inferred← citeshttps://doi.org/10.1007/978-1-4614-7978-9_6openalex-snapshot
Formulation Approaches and Strategies for Vaccines and Adjuvants
inferred← citeshttps://doi.org/10.1007/978-1-4614-9524-6_7openalex-snapshot
Pulmonary Delivery of Biopharmaceuticals
inferred← citeshttps://doi.org/10.1007/978-1-4939-3121-7_2openalex-snapshot
Cyclodextrin-Based Drug Carriers for Low Molecular Weight Drugs, Proteins, and Nucleic Acids
inferred← citeshttps://doi.org/10.1007/978-1-4939-3389-1_27openalex-snapshot
Formulation Studies During Preclinical Development of Influenza Hemagglutinin and Virus-Like Particle Vaccine Candidates
inferred← citeshttps://doi.org/10.1007/978-1-4939-7312-5_21openalex-snapshot
Polyester-Based Nanoparticles for Delivery of Therapeutic Proteins
inferred← citeshttps://doi.org/10.1007/978-1-60761-913-0_7openalex-snapshot
Engineering Protein Stability
inferred← citeshttps://doi.org/10.1007/978-1-61779-465-0_14openalex-snapshot
AGGRESCAN: Method, Application, and Perspectives for Drug Design
inferred← citeshttps://doi.org/10.1007/978-1-61779-921-1_28openalex-snapshot
Chitosan-Based Nanoparticles as Delivery Systems of Therapeutic Proteins
inferred← citeshttps://doi.org/10.1007/978-3-031-97554-7_22openalex-snapshot
Enzyme Stability Prediction: Advancing with Ensemble Machine Learning and Explainable Artificial Intelligence
inferred← citeshttps://doi.org/10.1007/978-3-319-57379-3_20openalex-snapshot
Molecular Chaperones in Neurodegenerative Diseases: A Short Review
inferred← citeshttps://doi.org/10.1007/978-3-319-90603-4_2openalex-snapshot
Polysorbate Degradation and Quality
inferred← citeshttps://doi.org/10.1007/978-3-319-95807-1_24openalex-snapshot
Ocular Delivery of Peptides and Proteins
inferred← citeshttps://doi.org/10.1007/978-3-642-29265-1_10openalex-snapshot
Nanosized Drug Delivery for Enhancement of Oral Bioavailability
inferred← citeshttps://doi.org/10.1007/978-3-7643-8679-5_2openalex-snapshot
Protein PEGylation, basic science and biological applications
inferred← citeshttps://doi.org/10.1007/978-3-7643-8679-5_6openalex-snapshot
The site-specific TGase-mediated PEGylation of proteins occurs at flexible sites
inferred← citeshttps://doi.org/10.1007/978-981-15-6426-0_4openalex-snapshot
Methods and Protocols for Drug Stability Studies
inferred← citeshttps://doi.org/10.1007/978-981-16-2051-5_3openalex-snapshot
Glycans Associated with Therapeutic Proteins
inferred← citeshttps://doi.org/10.1007/978-981-19-8249-1_11openalex-snapshot
Emerging Trends, Challenges, and Opportunities in Protein Therapeutics
inferred← citeshttps://doi.org/10.1007/978-981-99-5314-1_8openalex-snapshot
Protein Nanocarriers for the Delivery of Phytoconstituents
inferred← citeshttps://doi.org/10.1007/bf03346394openalex-snapshot
Pharmacy and pharmacology of biosimilars
inferred← citeshttps://doi.org/10.1007/s00018-007-6551-yopenalex-snapshot
Modulation of protein biophysical properties by chemical glycosylation: biochemical insights and biomedical implications
inferred← citeshttps://doi.org/10.1007/s00018-007-7404-4openalex-snapshot
We find them here, we find them there: Functional bacterial amyloid
inferred← citeshttps://doi.org/10.1007/s00044-014-1058-1openalex-snapshot
Novel isomannide-based peptide mimetics containing a tartaric acid backbone as serine protease inhibitors
inferred← citeshttps://doi.org/10.1007/s00216-014-7970-xopenalex-snapshot
Temperature denaturation and aggregation of a multi-domain protein (IgG1) investigated with an array of complementary biophysical methods
inferred← citeshttps://doi.org/10.1007/s00216-018-1127-2openalex-snapshot
Proteins and antibodies in serum, plasma, and whole blood—size characterization using asymmetrical flow field-flow fractionation (AF4)
inferred← citeshttps://doi.org/10.1007/s00216-022-04355-2openalex-snapshot
Investigation of native and aggregated therapeutic proteins in human plasma with asymmetrical flow field-flow fractionation and mass spectrometry
inferred← citeshttps://doi.org/10.1007/s00249-008-0346-4openalex-snapshot
Thermally induced denaturation and aggregation of BLG-A: effect of the Cu2+ and Zn2+ metal ions
inferred← citeshttps://doi.org/10.1007/s00249-019-01420-0openalex-snapshot
Amyloid formation of bovine insulin is retarded in moderately acidic pH and by addition of short-chain alcohols
inferred← citeshttps://doi.org/10.1007/s00253-011-3450-9openalex-snapshot
A novel anti-lymphoma protein RE26 from Rozites emodensis (Berk.) Moser
inferred← citeshttps://doi.org/10.1007/s00418-010-0726-6openalex-snapshot
Albumin-based nanoparticles as magnetic resonance contrast agents: II. Physicochemical characterisation of purified and standardised nanoparticles
inferred← citeshttps://doi.org/10.1007/s00894-014-2496-xopenalex-snapshot
A molecular simulation study of the protection of insulin bioactive structure by trehalose
inferred← citeshttps://doi.org/10.1007/s10118-026-3691-9openalex-snapshot
Silk Sericin-inspired Poly-β-homoserine for Protein Protection
inferred← citeshttps://doi.org/10.1007/s10337-019-03703-2openalex-snapshot
Stability-Indicating Size Exclusion Chromatography Method for the Analysis of IgG mAb-Cetuximab
inferred← citeshttps://doi.org/10.1007/s10439-009-9734-xopenalex-snapshot
Disulfide-Crosslinked Polyion Micelles for Delivery of Protein Therapeutics
inferred← citeshttps://doi.org/10.1007/s10529-006-9065-zopenalex-snapshot
Electron Capture Dissociation Mass Spectrometry in Characterization of Peptides and Proteins
inferred← citeshttps://doi.org/10.1007/s10529-007-9427-1openalex-snapshot
Oral administration of a fusion protein containing eight GLP-1 analogues produced in Escherichia coli BL21(DE3) in streptozotocin-induced diabetic rats
inferred← citeshttps://doi.org/10.1007/s10529-009-9947-yopenalex-snapshot
Enzymatic activity and thermal stability of PEG-α-chymotrypsin conjugates
inferred← citeshttps://doi.org/10.1007/s10847-014-0407-5openalex-snapshot
Improvement of pharmaceutical properties of insulin through conjugation with glucuronylglucosyl-β-cyclodextrin
inferred← citeshttps://doi.org/10.1007/s10853-018-3137-zopenalex-snapshot
Silk fibroin coaxial bead-on-string fiber materials and their drug release behaviors in different pH
inferred← citeshttps://doi.org/10.1007/s10856-012-4644-0openalex-snapshot
Calcium alginate/dextran methacrylate IPN beads as protecting carriers for protein delivery
inferred← citeshttps://doi.org/10.1007/s10867-014-9367-7openalex-snapshot
Determination of the second virial coefficient of bovine serum albumin under varying pH and ionic strength by composition-gradient multi-angle static light scattering
inferred← citeshttps://doi.org/10.1007/s10895-015-1576-3openalex-snapshot
Molecular Interactions of Flavonoids to Hyaluronidase: Insights from Spectroscopic and Molecular Modeling Studies
inferred← citeshttps://doi.org/10.1007/s10930-019-09837-4openalex-snapshot
Investigation on Secondary Structure Alterations of Protein Drugs as an Indicator of Their Biological Activity Upon Thermal Exposure
inferred← citeshttps://doi.org/10.1007/s10930-025-10302-8openalex-snapshot
Strategic Approaches for Overcoming Peptide and Protein Drug Limitations
inferred← citeshttps://doi.org/10.1007/s10973-016-5736-8openalex-snapshot
Cyclodextrin–protein interaction as inhibiting factor against aggregation
inferred← citeshttps://doi.org/10.1007/s10989-012-9305-0openalex-snapshot
Construction of a Functional-Complementary Dual Insulinotropic Peptide rolGG and Its Therapeutic Effect on Type 2 Diabetes
inferred← citeshttps://doi.org/10.1007/s10989-013-9346-zopenalex-snapshot
Expression of rolGLP-HV in E. coli and its Dual-Function for the Treatment of Diabetes and Thrombosis
inferred← citeshttps://doi.org/10.1007/s10989-014-9421-0openalex-snapshot
The Emergence of Cyclic Peptides: The Potential of Bioengineered Peptide Drugs
inferred← citeshttps://doi.org/10.1007/s10989-016-9562-4openalex-snapshot
Levan: A Biocompatible Homopolysaccharide Excipient for Stabilization of Peptide Drugs
inferred← citeshttps://doi.org/10.1007/s11095-006-9001-xopenalex-snapshot
Ligand-Targeted Delivery of Therapeutic siRNA
inferred← citeshttps://doi.org/10.1007/s11095-010-0073-2openalex-snapshot
Critical Evaluation of Nanoparticle Tracking Analysis (NTA) by NanoSight for the Measurement of Nanoparticles and Protein Aggregates
inferred← citeshttps://doi.org/10.1007/s11095-010-0116-8openalex-snapshot
The Molecular Chaperone α-Crystallin as an Excipient in an Insulin Formulation
inferred← citeshttps://doi.org/10.1007/s11095-011-0611-6openalex-snapshot
Mesoporous Silicon (PSi) for Sustained Peptide Delivery: Effect of PSi Microparticle Surface Chemistry on Peptide YY3-36 Release
inferred← citeshttps://doi.org/10.1007/s11095-012-0802-9openalex-snapshot
Structure-Activity Relationship for Hydrophobic Salts as Viscosity-Lowering Excipients for Concentrated Solutions of Monoclonal Antibodies
inferred← citeshttps://doi.org/10.1007/s11095-012-0854-xopenalex-snapshot
The Role of Polysorbate 80 and HPβCD at the Air-Water Interface of IgG Solutions
inferred← citeshttps://doi.org/10.1007/s11095-012-0871-9openalex-snapshot
Metal Ions Guided Self-assembly of Therapeutic Proteins for Controllable Release: From Random to Ordered Aggregation
inferred← citeshttps://doi.org/10.1007/s11095-012-0944-9openalex-snapshot
The Implantable and Biodegradable PHBHHx 3D Scaffolds Loaded with Protein-Phospholipid Complex for Sustained Delivery of Proteins
inferred← citeshttps://doi.org/10.1007/s11095-013-1017-4openalex-snapshot
Non-Aqueous Suspensions of Antibodies are Much Less Viscous Than Equally Concentrated Aqueous Solutions
inferred← citeshttps://doi.org/10.1007/s11095-013-1233-yopenalex-snapshot
Improving the Stability and Activity of Oral Therapeutic Enzymes—Recent Advances and Perspectives
inferred← citeshttps://doi.org/10.1007/s11095-014-1600-3openalex-snapshot
Purification and Identification of High Molecular Weight Products Formed During Storage of Neutral Formulation of Human Insulin
inferred← citeshttps://doi.org/10.1007/s11095-017-2208-1openalex-snapshot
Expression, Purification and Characterization of GMZ2’.10C, a Complex Disulphide-Bonded Fusion Protein Vaccine Candidate against the Asexual and Sexual Life-Stages of the Malaria-Causing Plasmodium falciparum Parasite
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