On the public citation graph
Emerging principles in protease-based drug discovery
0 signed · 709 inferred · view as graph
Inferred edges come from two machine sources: sweeps of open repository metadata (mostly SSRN and Zenodo), and a bulk OpenAlex citation snapshot. Every row below is labelled with the one it came from. Neither is a complete citation index — absence here is not evidence of absence.
1 of the 128 references listed on this page is in the Retraction Watch database as retracted (export 2026-10-28): 10.1074/jbc.m000464200 (notice 2007-09-28).
Dataset join, best-effort; this page does not check the publisher record. Retraction Watch data via Crossref Labs, used with credit; OpenCitations Index (CC0) and Meta (CC BY 4.0); dataset doi:10.7910/DVN/WT8VOA (CC BY 4.0).
Is this your work? Sign in with ORCID and put your name on the
claims that are yours.
Reference health. See whether every reference in this work resolves to a
known work and none has been retracted — and get a dated CiteStamped
badge you can embed.
What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1002/anie.200702811openalex-snapshot
Selective Activity‐Based Probes for Cysteine Cathepsins
inferredcites →https://doi.org/10.1002/anie.200800736openalex-snapshot
An Engineered Protease that Cleaves Specifically after Sulfated Tyrosine
inferredcites →https://doi.org/10.1002/cbic.200500427openalex-snapshot
Mapping Protease Substrates by Using a Biotinylated Phage Substrate Library
inferredcites →https://doi.org/10.1002/elps.200800698openalex-snapshot
“Reverse degradomics”, monitoring of proteolytic trimming by multi‐CE and confocal detection of fluorescent substrates and reaction products
inferredcites →https://doi.org/10.1002/pmic.200900418openalex-snapshot
MS‐driven protease substrate degradomics
inferredcites →https://doi.org/10.1006/jmbi.2001.5394openalex-snapshot
The Methyl Group of Nα(Me)Arg-containing Peptides Disturbs the Active-site Geometry of Thrombin, Impairing Efficient Cleavage
inferredcites →https://doi.org/10.1007/978-1-60327-003-8_4openalex-snapshot
Positional Scanning Synthetic Combinatorial Libraries for Substrate Profiling
inferredcites →https://doi.org/10.1007/s10555-006-7890-0openalex-snapshot
Degradomics: Systems biology of the protease web. Pleiotropic roles of MMPs in cancer
inferredcites →https://doi.org/10.1016/j.bcp.2005.04.047openalex-snapshot
Targeting neutrophil collagenase/matrix metalloproteinase-8 and gelatinase B/matrix metalloproteinase-9 with a peptidomimetic inhibitor protects against endotoxin shock
inferredcites →https://doi.org/10.1016/j.biochi.2007.07.023openalex-snapshot
The initiating proteases of the complement system: Controlling the cleavage
inferredcites →https://doi.org/10.1016/j.cell.2006.02.038openalex-snapshot
The Ubiquitin Binding Domain ZnF UBP Recognizes the C-Terminal Diglycine Motif of Unanchored Ubiquitin
inferredcites →https://doi.org/10.1016/j.chembiol.2003.08.010openalex-snapshot
Discovery of Inhibitors that Elucidate the Role of UCH-L1 Activity in the H1299 Lung Cancer Cell Line
inferredcites →https://doi.org/10.1016/j.drudis.2007.06.008openalex-snapshot
A new paradigm for protein kinase inhibition: blocking phosphorylation without directly targeting ATP binding
inferredcites →https://doi.org/10.1016/j.jmb.2006.01.039openalex-snapshot
Multiple Solvent Crystal Structures: Probing Binding Sites, Plasticity and Hydration
inferredcites →https://doi.org/10.1016/j.str.2004.05.023openalex-snapshot
A Basis for SUMO Protease Specificity Provided by Analysis of Human Senp2 and a Senp2-SUMO Complex
inferredcites →https://doi.org/10.1016/j.str.2006.06.012openalex-snapshot
Structural Basis of Ubiquitin Recognition by the Deubiquitinating Protease USP2
inferredcites →https://doi.org/10.1016/j.str.2007.03.014openalex-snapshot
Inhibition of Caspase-2 by a Designed Ankyrin Repeat Protein: Specificity, Structure, and Inhibition Mechanism
inferredcites →https://doi.org/10.1016/j.tips.2007.10.011openalex-snapshot
Cysteine cathepsin proteases as pharmacological targets in cancer
inferredcites →https://doi.org/10.1016/j.ymeth.2005.07.005openalex-snapshot
Methods to measure ubiquitin-dependent proteolysis mediated by the anaphase-promoting complex
inferredcites →https://doi.org/10.1016/s0006-291x(67)80055-xopenalex-snapshot
On the size of the active site in proteases. I. Papain
inferredcites →https://doi.org/10.1016/s0025-7125(16)32425-7openalex-snapshot
The Normal Coagulation Mechanism
inferredcites →https://doi.org/10.1016/s0092-8674(00)00130-6openalex-snapshot
Cleavage of Cohesin by the CD Clan Protease Separin Triggers Anaphase in Yeast
inferredcites →https://doi.org/10.1016/s0968-0896(99)00008-5openalex-snapshot
Cysteine protease inhibitors as chemotherapy for parasitic infections
inferredcites →https://doi.org/10.1016/s1074-5521(97)90258-1openalex-snapshot
A combinatorial approach for determining protease specificities: application to interleukin-1β converting enzyme (ICE)
inferredcites →https://doi.org/10.1016/s1535-6108(02)00024-7openalex-snapshot
A matter of life and death
inferredcites →https://doi.org/10.1016/s1535-6108(03)00332-5openalex-snapshot
Small-molecule antagonists of apoptosis suppressor XIAP exhibit broad antitumor activity
inferredcites →https://doi.org/10.1017/s1462399408000811openalex-snapshot
Recent advances in understanding the molecular basis of group BStreptococcusvirulence
inferredcites →https://doi.org/10.1021/ac048631popenalex-snapshot
Simulation of Evolution-Selected Propeptide by High-Throughput Selection of a Peptidomimetic Inhibitor on a Capillary DNA Sequencer Platform
inferredcites →https://doi.org/10.1021/bi026878fopenalex-snapshot
Potent and Selective Inhibition of Membrane-Type Serine Protease 1 by Human Single-Chain Antibodies
inferredcites →https://doi.org/10.1021/bi050932lopenalex-snapshot
An Inhibitor Binding Pocket Distinct from the Catalytic Active Site on Human β-APP Cleaving Enzyme
inferredcites →https://doi.org/10.1021/bi052252oopenalex-snapshot
MMP-20 Is Predominately a Tooth-Specific Enzyme with a Deep Catalytic Pocket that Hydrolyzes Type V Collagen
inferredcites →https://doi.org/10.1021/bi9003638openalex-snapshot
The M17 Leucine Aminopeptidase of the Malaria Parasite Plasmodium falciparum: Importance of Active Site Metal Ions in the Binding of Substrates and Inhibitors
inferredcites →https://doi.org/10.1021/cr010180aopenalex-snapshot
Catalytic Antibodies as Designer Proteases and Esterases
inferredcites →https://doi.org/10.1021/cr9402081openalex-snapshot
Synthesis and Applications of Small Molecule Libraries
inferredcites →https://doi.org/10.1021/ja0547230openalex-snapshot
Substrate Activity Screening: A Fragment-Based Method for the Rapid Identification of Nonpeptidic Protease Inhibitors
inferredcites →https://doi.org/10.1021/ja710254mopenalex-snapshot
Identification of a New Class of Nonpeptidic Inhibitors of Cruzain
inferredcites →https://doi.org/10.1021/jm030628vopenalex-snapshot
Dipeptidyl Peptidase IV Inhibitors for the Treatment of Diabetes
inferredcites →https://doi.org/10.1021/jm0493156openalex-snapshot
(2 R )-4-Oxo-4-[3-(Trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3- a ]pyrazin- 7(8 H )-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine: A Potent, Orally Active Dipeptidyl Peptidase IV Inhibitor for the Treatment of Type 2 Diabetes
inferredcites →https://doi.org/10.1021/jm070111+openalex-snapshot
Characterization and Optimization of Selective, Nonpeptidic Inhibitors of Cathepsin S with an Unprecedented Binding Mode
inferredcites →https://doi.org/10.1021/jm070330vopenalex-snapshot
Discovery of Potent and Selective Dipeptidyl Peptidase IV Inhibitors Derived from β-Aminoamides Bearing Subsituted Triazolopiperazines
inferredcites →https://doi.org/10.1021/jm070733vopenalex-snapshot
Identification of Phosphinate Dipeptide Analog Inhibitors Directed against the Plasmodium falciparum M17 Leucine Aminopeptidase as Lead Antimalarial Compounds
inferredcites →https://doi.org/10.1023/b:thro.0000037670.42776.cdopenalex-snapshot
The Occasional Venous Thromboses Seen in Patients with Severe (Homozygous) FXII Deficiency are Probably Due to Associated Risk Factors: A Study of Prevalence in 21 Patients and Review of the Literature
inferredcites →https://doi.org/10.1038/299555a0openalex-snapshot
Potent new inhibitors of human renin
inferredcites →https://doi.org/10.1038/72642openalex-snapshot
Synthesis of positional-scanning libraries of fluorogenic peptide substrates to define the extended substrate specificity of plasmin and thrombin
inferredcites →https://doi.org/10.1038/90273openalex-snapshot
Determination of protease cleavage site motifs using mixture-based oriented peptide libraries
inferredcites →https://doi.org/10.1038/cdd.2008.23openalex-snapshot
Activation mechanism and substrate specificity of the Drosophila initiator caspase DRONC
inferredcites →https://doi.org/10.1038/nbt786openalex-snapshot
In situ assembly of enzyme inhibitors using extended tethering
inferredcites →https://doi.org/10.1038/nbt860openalex-snapshot
Engineering of a macromolecular scaffold to develop specific protease inhibitors
inferredcites →https://doi.org/10.1038/nchembio.192openalex-snapshot
Inhibition of a viral enzyme by a small-molecule dimer disruptor
inferredcites →https://doi.org/10.1038/nchembio.80openalex-snapshot
Highly active and selective endopeptidases with programmed substrate specificities
inferredcites →https://doi.org/10.1038/nchembio.98openalex-snapshot
Allosteric regulation and catalysis emerge via a common route
inferredcites →https://doi.org/10.1038/ni.1714openalex-snapshot
Death receptor signal transducers: nodes of coordination in immune signaling networks
inferredcites →https://doi.org/10.1038/nm782openalex-snapshot
Real-time in vivo imaging of platelets, tissue factor and fibrin during arterial thrombus formation in the mouse
inferredcites →https://doi.org/10.1038/nrc2228openalex-snapshot
Emerging roles of proteases in tumour suppression
inferredcites →https://doi.org/10.1038/nrd2092openalex-snapshot
Targeting proteases: successes, failures and future prospects
inferredcites →https://doi.org/10.1038/nrd2308openalex-snapshot
Matrix metalloproteinase inhibitors as therapy for inflammatory and vascular diseases
inferredcites →https://doi.org/10.1038/nrd2550openalex-snapshot
Aliskiren: the first renin inhibitor for clinical treatment
inferredcites →https://doi.org/10.1038/nrd2606openalex-snapshot
Perspectives on NMR in drug discovery: a technique comes of age
inferredcites →https://doi.org/10.1038/nrd2760openalex-snapshot
Allosteric modulators of GPCRs: a novel approach for the treatment of CNS disorders
inferredcites →https://doi.org/10.1038/nrm2153openalex-snapshot
The apoptosome: signalling platform of cell death
inferredcites →https://doi.org/10.1038/nsmb.1668openalex-snapshot
Structural and kinetic determinants of protease substrates
inferredcites →https://doi.org/10.1038/nsmb708openalex-snapshot
The structural basis for substrate and inhibitor selectivity of the anthrax lethal factor
inferredcites →https://doi.org/10.1038/sj.bjc.6603043openalex-snapshot
Towards third generation matrix metalloproteinase inhibitors for cancer therapy
inferredcites →https://doi.org/10.1038/sj.clpt.6100167openalex-snapshot
Dipeptidyl Peptidase-4 Inhibitors for the Treatment of Type 2 Diabetes: Focus On Sitagliptin
inferredcites →https://doi.org/10.1038/sj.embor.7400795openalex-snapshot
Human inhibitor of apoptosis proteins: why XIAP is the black sheep of the family
inferredcites →https://doi.org/10.1042/bj20021643openalex-snapshot
Catalytic properties and inhibition of proline-specific dipeptidyl peptidases II, IV and VII
inferredcites →https://doi.org/10.1042/bj20041142openalex-snapshot
The protein structures that shape caspase activity, specificity, activation and inhibition
inferredcites →https://doi.org/10.1042/bj20070940openalex-snapshot
Activity profiling of human deSUMOylating enzymes (SENPs) with synthetic substrates suggests an unexpected specificity of two newly characterized members of the family
inferredcites →https://doi.org/10.1042/bj20080779openalex-snapshot
Positional-scanning fluorigenic substrate libraries reveal unexpected specificity determinants of DUBs (deubiquitinating enzymes)
inferredcites →https://doi.org/10.1042/bj20091645openalex-snapshot
Identification of broad-based HIV-1 protease inhibitors from combinatorial libraries
inferredcites →https://doi.org/10.1055/s-2007-996129openalex-snapshot
Development of Argatroban, a Direct Thrombin Inhibitor, and Its Clinical Application
inferredcites →https://doi.org/10.1073/pnas.0404781101openalex-snapshot
Discovery of an allosteric site in the caspases
inferredcites →https://doi.org/10.1073/pnas.0502733102openalex-snapshot
Efficient synthetic inhibitors of anthrax lethal factor
inferredcites →https://doi.org/10.1073/pnas.0604101103openalex-snapshot
Inhibitors of Plasmodium falciparum methionine aminopeptidase 1b possess antimalarial activity
inferredcites →https://doi.org/10.1073/pnas.081026598openalex-snapshot
Activation of a protease cascade involved in patterning the Drosophila embryo
inferredcites →https://doi.org/10.1073/pnas.140132697openalex-snapshot
Rapid and general profiling of protease specificity by using combinatorial fluorogenic substrate libraries
inferredcites →https://doi.org/10.1074/jbc.270.43.25411openalex-snapshot
Potent and Selective Kunitz Domain Inhibitors of Plasma Kallikrein Designed by Phage Display
inferredcites →https://doi.org/10.1074/jbc.272.29.17907openalex-snapshot
A Combinatorial Approach Defines Specificities of Members of the Caspase Family and Granzyme B
inferredcites →https://doi.org/10.1074/jbc.m000464200openalex-snapshot
Thrombin-mediated Feedback Activation of Factor XI on the Activated Platelet Surface Is Preferred over Contact Activation by Factor XIIa or Factor XIa
inferredcites →https://doi.org/10.1074/jbc.m500588200openalex-snapshot
Functional Profiling of Recombinant NS3 Proteases from All Four Serotypes of Dengue Virus Using Tetrapeptide and Octapeptide Substrate Libraries
inferredcites →https://doi.org/10.1074/jbc.m505933200openalex-snapshot
A Urokinase-type Plasminogen Activator-inhibiting Cyclic Peptide with an Unusual P2 Residue and an Extended Protease Binding Surface Demonstrates New Modalities for Enzyme Inhibition
inferredcites →https://doi.org/10.1074/jbc.m513331200openalex-snapshot
Substrate Profiling of Cysteine Proteases Using a Combinatorial Peptide Library Identifies Functionally Unique Specificities
inferredcites →https://doi.org/10.1074/jbc.m609251200openalex-snapshot
Characterization of the Plasmodium falciparum M17 Leucyl Aminopeptidase
inferredcites →https://doi.org/10.1074/jbc.m702444200openalex-snapshot
Small Ubiquitin-related Modifier (SUMO)-specific Proteases
inferredcites →https://doi.org/10.1074/jbc.r100016200openalex-snapshot
The Serpins Are an Expanding Superfamily of Structurally Similar but Functionally Diverse Proteins
inferredcites →https://doi.org/10.1074/jbc.x300009200openalex-snapshot
A Brief Historical Review of the Waterfall/Cascade of Blood Coagulation
inferredcites →https://doi.org/10.1080/10409230290771546openalex-snapshot
Biochemistry and Molecular Biology of Gelatinase B or Matrix Metalloproteinase-9 (MMP-9)
inferredcites →https://doi.org/10.1080/10409230701340019openalex-snapshot
The Biochemical, Biological, and Pathological Kaleidoscope of Cell Surface Substrates Processed by Matrix Metalloproteinases
inferredcites →https://doi.org/10.1081/cnv-120030218openalex-snapshot
Development of the Proteasome Inhibitor Velcade™ (Bortezomib)
inferredcites →https://doi.org/10.1083/jcb.200807195openalex-snapshot
Protease-dependent versus -independent cancer cell invasion programs: three-dimensional amoeboid movement revisited
inferredcites →https://doi.org/10.1093/bioinformatics/btp036openalex-snapshot
Fragment-based identification of druggable ‘hot spots’ of proteins using Fourier domain correlation techniques
inferredcites →https://doi.org/10.1111/j.1538-7836.2004.01021.xopenalex-snapshot
Exosite-driven substrate specificity and function in coagulation
inferredcites →https://doi.org/10.1111/j.1538-7836.2008.03220.xopenalex-snapshot
New insights into the molecular mechanisms of the fibrinolytic system
inferredcites →https://doi.org/10.1126/science.1067100openalex-snapshot
Matrix Metalloproteinase Inhibitors and Cancer—Trials and Tribulations
inferredcites →https://doi.org/10.1126/science.1162403openalex-snapshot
Small Molecule-Induced Allosteric Activation of the Vibrio cholerae RTX Cysteine Protease Domain
inferredcites →https://doi.org/10.1126/science.2374926openalex-snapshot
The Structure of a Complex of Recombinant Hirudin and Human α-Thrombin
inferredcites →https://doi.org/10.1126/science.289.5482.1202openalex-snapshot
Inflammation Dampened by Gelatinase A Cleavage of Monocyte Chemoattractant Protein-3
inferredcites →https://doi.org/10.1126/science.8493554openalex-snapshot
Substrate Phage: Selection of Protease Substrates by Monovalent Phage Display
inferredcites →https://doi.org/10.1128/aac.01327-07openalex-snapshot
Chemical Target Validation Studies of Aminopeptidase in Malaria Parasites Using α-Aminoalkylphosphonate and Phosphonopeptide Inhibitors
inferredcites →https://doi.org/10.1146/annurev.bi.44.070175.004055openalex-snapshot
Basic Mechanisms in Blood Coagulation
inferredcites →https://doi.org/10.1146/annurev.biochem.78.082307.091526openalex-snapshot
Regulation and Cellular Roles of Ubiquitin-Specific Deubiquitinating Enzymes
inferredcites →https://doi.org/10.1158/0008-5472.can-05-2983openalex-snapshot
Antibodies Neutralizing Hepsin Protease Activity Do Not Impact Cell Growth but Inhibit Invasion of Prostate and Ovarian Tumor Cells in Culture
inferredcites →https://doi.org/10.1158/0008-5472.can-08-3255openalex-snapshot
Selective Inhibition of Matrix Metalloproteinase-14 Blocks Tumor Growth, Invasion, and Angiogenesis
inferredcites →https://doi.org/10.1182/blood-2002-12-3791openalex-snapshot
Amoeboid shape change and contact guidance: T-lymphocyte crawling through fibrillar collagen is independent of matrix remodeling by MMPs and other proteases
inferredcites →https://doi.org/10.1182/blood.v14.11.1230.1230openalex-snapshot
Use of the Plasma Thrombin Time to Assess the Adequacy of in Vivo Neutralization of Heparin: Comparative Studies Following Operations Employing Extracorporeal Circulation
inferredcites →https://doi.org/10.1183/09031936.00159606openalex-snapshot
Revisiting α1-antitrypsin therapy in cystic fibrosis: can it still offer promise?
inferredcites →https://doi.org/10.1185/03007990903152045openalex-snapshot
ACE inhibitors, angiotensin receptor blockers and direct renin inhibitors in combination: a review of their role after the ONTARGET trial
inferredcites →https://doi.org/10.1515/bc.2004.129openalex-snapshot
Activation of the kallikrein-kinin system and release of new kinins through alternative cleavage of kininogens by microbial and human cell proteinases
inferredcites →https://doi.org/10.1517/13543784.15.9.1077openalex-snapshot
The therapeutic potential of a kallikrein inhibitor for treating hereditary angioedema
inferredcites →https://doi.org/10.1586/14779072.5.4.733openalex-snapshot
Role of Factor XII in hemostasis and thrombosis: clinical implications
inferredcites →https://doi.org/10.2147/vhrm.s3364openalex-snapshot
Renin inhibition with aliskiren in hypertension: focus on aliskiren/hydrochlorothiazide combination therapy
inferredcites →https://doi.org/10.2174/0929867043364568openalex-snapshot
Inhibitors of Tissue Factor • Factor VIIa for Anticoagulant Therapy
inferredcites →https://doi.org/10.2174/1381612023394124openalex-snapshot
Regulating Cysteine Protease Activity: Essential Role of Protease Inhibitors As Guardians and Regulators
inferredcites →https://doi.org/10.2174/156800908786733478openalex-snapshot
ADAM Proteins- Therapeutic Potential in Cancer
inferredcites →https://doi.org/10.2174/1568026043388015openalex-snapshot
The Evolution of the Matrix Metalloproteinase Inhibitor Drug Discovery Program at Abbott Laboratories
inferredcites →https://doi.org/10.2174/156802607780091028openalex-snapshot
Discovery of JANUVIA™ (Sitagliptin), a Selective Dipeptidyl Peptidase IV Inhibitor for the Treatment of Type2 Diabetes.
inferredcites →https://doi.org/10.7270/q2z31wxkopenalex-snapshot
BindingDB Entry 2158: Tumor suppression by a rationally designed reversible inhibitor of methionine aminopeptidase-2.
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
inferred← citeshttps://doi.org/10.1016/j.phytochem.2020.112595zenodo-depositor-declared
Bioengineering of an elastase inhibitor from Caesalpinia echinata (Brazil wood) seeds
inferred← citeshttps://doi.org/10.3217/jucs-024-06-0711openalex-extracted
Identifying Cleavage Sites of Gelatinases A and B by Integrating Feature Computing Models
inferred← citeshttps://doi.org/10.1002/1873-3468.13109openalex-snapshot
Mechanisms of cell regulation – proteolysis, the big surprise
inferred← citeshttps://doi.org/10.1002/1873-3468.13191openalex-snapshot
Crystal structure of plasma kallikrein reveals the unusual flexibility of the S1 pocket triggered by Glu217
inferred← citeshttps://doi.org/10.1002/1873-3468.13531openalex-snapshot
Estimating kinetic constants in the Michaelis–Menten model from one enzymatic assay using Approximate Bayesian Computation
inferred← citeshttps://doi.org/10.1002/9781118493816.ch12openalex-snapshot
The proteolytic repertoire of malaria parasites
inferred← citeshttps://doi.org/10.1002/9781118739907.ch1openalex-snapshot
ASSAY TECHNOLOGIES FOR PROTEASES
inferred← citeshttps://doi.org/10.1002/9781119300229.ch11openalex-snapshot
Screening Combinatorial Peptide Libraries in Protease Inhibitor Drug Discovery
inferred← citeshttps://doi.org/10.1002/9781119300229.ch12openalex-snapshot
Chemical Probes Targeting Proteases for Imaging and Diagnostics in Cancer
inferred← citeshttps://doi.org/10.1002/ajoc.202400598openalex-snapshot
Novel Cyclopropyl Appended 1,3‐Thiazole‐2‐Imines as Multi‐Target Agents: Design, Synthesis, Biological Evaluation and Computational Studies
inferred← citeshttps://doi.org/10.1002/ange.201107795openalex-snapshot
Multiplex Imaging of an Intracellular Proteolytic Cascade by using a Broad‐Spectrum Nanoquencher
inferred← citeshttps://doi.org/10.1002/ange.201701771openalex-snapshot
Maßgeschneiderte Ahp‐Cyclodepsipeptide als potente, nicht‐kovalente Serinprotease‐Inhibitoren
inferred← citeshttps://doi.org/10.1002/ange.202006919openalex-snapshot
Der Sonnenblumen‐Trypsin‐Inhibitor 1 (SFTI‐1) in der Chemie und Biologie
inferred← citeshttps://doi.org/10.1002/ange.202106639openalex-snapshot
Peptide Nucleic Acid (PNA)‐Guided Peptide Engineering of an Aptamer Sensor for Protease‐Triggered Molecular Imaging
inferred← citeshttps://doi.org/10.1002/ange.202108847openalex-snapshot
Diarylethen‐basierte lichtschaltbare Inhibitoren von Serinproteasen
inferred← citeshttps://doi.org/10.1002/ange.202110027openalex-snapshot
Inhibition Mechanism of SARS‐CoV‐2 Main Protease with Ketone‐Based Inhibitors Unveiled by Multiscale Simulations: Insights for Improved Designs**
inferred← citeshttps://doi.org/10.1002/ange.202507241openalex-snapshot
A Versatile DNAzyme‐Amplified Protease‐Sensing Platform for Accurate Diagnosis of SARS‐CoV‐2 and Reliable Classification of Colorectal Cancer
inferred← citeshttps://doi.org/10.1002/ange.8169928openalex-snapshot
Spatially Controlled Imaging of Proteases in Acidic Extracellular Milieu of Lesions Using DNA‐Peptide‐PNA Hybrid Probes
inferred← citeshttps://doi.org/10.1002/anie.201107795openalex-snapshot
Multiplex Imaging of an Intracellular Proteolytic Cascade by using a Broad‐Spectrum Nanoquencher
inferred← citeshttps://doi.org/10.1002/anie.201701771openalex-snapshot
Tailored Ahp‐cyclodepsipeptides as Potent Non‐covalent Serine Protease Inhibitors
inferred← citeshttps://doi.org/10.1002/anie.202006919openalex-snapshot
Sunflower Trypsin Inhibitor‐1 (SFTI‐1): Sowing Seeds in the Fields of Chemistry and Biology
inferred← citeshttps://doi.org/10.1002/anie.202106639openalex-snapshot
Peptide Nucleic Acid (PNA)‐Guided Peptide Engineering of an Aptamer Sensor for Protease‐Triggered Molecular Imaging
inferred← citeshttps://doi.org/10.1002/anie.202108847openalex-snapshot
Diarylethene‐Based Photoswitchable Inhibitors of Serine Proteases
inferred← citeshttps://doi.org/10.1002/anie.202110027openalex-snapshot
Inhibition Mechanism of SARS‐CoV‐2 Main Protease with Ketone‐Based Inhibitors Unveiled by Multiscale Simulations: Insights for Improved Designs**
inferred← citeshttps://doi.org/10.1002/anie.202507241openalex-snapshot
A Versatile DNAzyme‐Amplified Protease‐Sensing Platform for Accurate Diagnosis of SARS‐CoV‐2 and Reliable Classification of Colorectal Cancer
inferred← citeshttps://doi.org/10.1002/anie.8169928openalex-snapshot
Spatially Controlled Imaging of Proteases in Acidic Extracellular Milieu of Lesions Using DNA‐Peptide‐PNA Hybrid Probes
inferred← citeshttps://doi.org/10.1002/asia.202200200openalex-snapshot
Photoresponsive Small Molecule Inhibitors for the Remote Control of Enzyme Activity
inferred← citeshttps://doi.org/10.1002/biof.2001openalex-snapshot
Advances in screening, synthesis, modification, and biomedical applications of peptides and peptide aptamers
inferred← citeshttps://doi.org/10.1002/bip.22231openalex-snapshot
Mechanism‐based selection of a potent kallikrein‐related peptidase 7 inhibitor from a versatile library based on the sunflower trypsin inhibitor SFTI‐1
inferred← citeshttps://doi.org/10.1002/bit.24964openalex-snapshot
Development of a periplasmic FRET screening method for protease inhibitory antibodies
inferred← citeshttps://doi.org/10.1002/bit.27519openalex-snapshot
Generation of highly selective monoclonal antibodies inhibiting a recalcitrant protease using decoy designs
inferred← citeshttps://doi.org/10.1002/cbic.201300180openalex-snapshot
Ahp Cyclodepsipeptides: The Impact of the Ahp Residue on the “Canonical Inhibition” of S1 Serine Proteases
inferred← citeshttps://doi.org/10.1002/cbic.201402108openalex-snapshot
Peptidyl Succinimidyl Peptides as Taspase 1 Inhibitors
inferred← citeshttps://doi.org/10.1002/chem.201201468openalex-snapshot
Turn‐On Fluorescence Sensor Based on Single‐Walled‐Carbon‐Nanohorn–Peptide Complex for the Detection of Thrombin
inferred← citeshttps://doi.org/10.1002/chem.201904513openalex-snapshot
Quantum Mechanics/Molecular Mechanics Studies of the Mechanism of Cysteine Proteases Inhibition by Dipeptidyl Nitroalkenes
inferred← citeshttps://doi.org/10.1002/chem.202301855openalex-snapshot
Next Generation of Fluorometric Protease Assays: 7‐Nitrobenz‐2‐oxa‐1,3‐diazol‐4‐yl‐amides (NBD‐Amides) as Class‐Spanning Protease Substrates
inferred← citeshttps://doi.org/10.1002/cmdc.201200057openalex-snapshot
Activity‐Based Probes for the Study of Proteases: Recent Advances and Developments
inferred← citeshttps://doi.org/10.1002/cmdc.201300112openalex-snapshot
Optimization of Triazine Nitriles as Rhodesain Inhibitors: Structure–Activity Relationships, Bioisosteric Imidazopyridine Nitriles, and X‐ray Crystal Structure Analysis with Human Cathepsin L
inferred← citeshttps://doi.org/10.1002/cmdc.201900193openalex-snapshot
Chemical Validation of DegS As a Target for the Development of Antibiotics with a Novel Mode of Action
inferred← citeshttps://doi.org/10.1002/ddr.21062openalex-snapshot
Proteolytic Enzymes as Biomarkers of Focal Segmental Glomerulosclerosis
inferred← citeshttps://doi.org/10.1002/elan.201300184openalex-snapshot
G‐Quadruplex‐Linked Supersandwich DNA Structure for Electrochemical Amplified Detection of Thrombin
inferred← citeshttps://doi.org/10.1002/ijch.201300144openalex-snapshot
From Catalytic Mechanism to Rational Design of Reversible Covalent Inhibitors of Serine and Cysteine Hydrolases
inferred← citeshttps://doi.org/10.1002/iub.2700openalex-snapshot
The roles of proteases in prostate cancer
inferred← citeshttps://doi.org/10.1002/jmr.2727openalex-snapshot
Electrostatic recognition in substrate binding to serine proteases
inferred← citeshttps://doi.org/10.1002/jrs.4995openalex-snapshot
Amino‐methyl coumarin as a potential SERS@Ag probe for the evaluation of protease activity and inhibition
inferred← citeshttps://doi.org/10.1002/med.21503openalex-snapshot
Recent advances in the discovery and development of factor XI/XIa inhibitors
inferred← citeshttps://doi.org/10.1002/minf.201300099openalex-snapshot
Application of EMBM to Structure‐Based Design of Warheads for Protease Inhibitors
inferred← citeshttps://doi.org/10.1002/pep2.24377openalex-snapshot
In Silico Analysis of Conformational Dynamics and Energetic Landscapes of Putative Insulinase PF11_0189 From the Plasmodium falciparum Genome With Insulin‐Derived Peptides: Approach to Rationale Design of Insulin Peptide‐Based Inhibitors
inferred← citeshttps://doi.org/10.1002/prca.201300037openalex-snapshot
Sample collection in clinical proteomics—Proteolytic activity profile of serum and plasma
inferred← citeshttps://doi.org/10.1002/prca.201300085openalex-snapshot
Cysteine cathepsins and their potential in clinical therapy and biomarker discovery
inferred← citeshttps://doi.org/10.1002/pro.2732openalex-snapshot
Engineering trypsin for inhibitor resistance
inferred← citeshttps://doi.org/10.1002/pro.4691openalex-snapshot
Substrate derived sequences act as subsite‐blocking motifs in protease inhibitory antibodies
inferred← citeshttps://doi.org/10.1002/pro.4979openalex-snapshot
Integrating the analysis of human biopsies using post‐translational modifications proteomics
inferred← citeshttps://doi.org/10.1002/pro.70688openalex-snapshot
Achieving protease substrate‐specific inhibition by mAb dual functional selections
inferred← citeshttps://doi.org/10.1002/slct.202507173openalex-snapshot
Unveiling the Novel Multitarget Antidepressant Mechanisms of Ligustilide in Postpartum Depression: An Integrative Network Pharmacology and Molecular Simulation Study
inferred← citeshttps://doi.org/10.1002/smll.201201983openalex-snapshot
Protein‐Protected Au Clusters as a New Class of Nanoscale Biosensor for Label‐Free Fluorescence Detection of Proteases
inferred← citeshttps://doi.org/10.1002/smll.201805384openalex-snapshot
Transducing Protease Activity into DNA Output for Developing Smart Bionanosensors
inferred← citeshttps://doi.org/10.1007/978-1-0716-3589-6_19openalex-snapshot
Generation of Protease Inhibitory Antibodies by Functional In Vivo Selection
inferred← citeshttps://doi.org/10.1007/978-1-4614-9099-9_18openalex-snapshot
Implications of Intracellular Proteolytic Activation of MMP-2 in the Heart
inferred← citeshttps://doi.org/10.1007/978-1-4614-9233-7_9openalex-snapshot
Proteases as Virulence Factors in Leishmania: Focus on Serine Proteases as Possible Therapeutic Targets
inferred← citeshttps://doi.org/10.1007/978-1-4939-0357-3_2openalex-snapshot
Positional Scanning Substrate Combinatorial Library (PS-SCL) Approach to Define Caspase Substrate Specificity
inferred← citeshttps://doi.org/10.1007/978-1-4939-6646-2_4openalex-snapshot
Multifunctional Concentric FRET-Quantum Dot Probes for Tracking and Imaging of Proteolytic Activity
inferred← citeshttps://doi.org/10.1007/978-1-4939-6952-4_4openalex-snapshot
Degradomics in Neurotrauma: Profiling Traumatic Brain Injury
inferred← citeshttps://doi.org/10.1007/978-1-4939-7595-2_26openalex-snapshot
Generation of Highly Selective MMP Antibody Inhibitors
inferred← citeshttps://doi.org/10.1007/978-1-4939-8814-3_20openalex-snapshot
Proteases: Pivot Points in Functional Proteomics
inferred← citeshttps://doi.org/10.1007/978-3-030-80662-0_14openalex-snapshot
Nanomedicine Treatment Strategies That Exploit Unique Characteristics of Tumor Vasculature and Microenvironment
inferred← citeshttps://doi.org/10.1007/978-3-031-76718-0_15openalex-snapshot
Molecular Modeling Strategies in Drug Design, Development, and Discovery Targeting Proteases
inferred← citeshttps://doi.org/10.1007/978-3-031-78459-0_4openalex-snapshot
Docking and Post-Processing of 1 Million Molecules from the CNCL Database in Search of SARS-CoV-2 Mpro Inhibitors
inferred← citeshttps://doi.org/10.1007/978-3-031-80866-1_41-1openalex-snapshot
Algal Polyketide Biosynthesis: Mechanism, Types, and Biotechnological Potential
inferred← citeshttps://doi.org/10.1007/978-3-319-19456-1_10-1openalex-snapshot
Fungal Protease Inhibitors
inferred← citeshttps://doi.org/10.1007/978-3-319-19497-4_5openalex-snapshot
Proteases in Apoptosis: Protocols and Methods
inferred← citeshttps://doi.org/10.1007/978-3-319-23603-2_6openalex-snapshot
Functional Implications of Domain Organization Within Prokaryotic Rhomboid Proteases
inferred← citeshttps://doi.org/10.1007/978-3-319-25001-4_10openalex-snapshot
Fungal Protease Inhibitors
inferred← citeshttps://doi.org/10.1007/978-3-319-28368-5_7openalex-snapshot
Bacterial Proteases as Targets to Control Bacterial Growth
inferred← citeshttps://doi.org/10.1007/978-3-319-74974-7_12openalex-snapshot
System Biology to Access Target Relevance in the Research and Development of Molecular Inhibitors
inferred← citeshttps://doi.org/10.1007/978-3-7091-0885-7_3openalex-snapshot
Compartmentalization of Proteolysis
inferred← citeshttps://doi.org/10.1007/978-3-7091-0885-7_5openalex-snapshot
Limited and Degradative Proteolysis in the Context of Posttranslational Regulatory Networks: Current Technical and Conceptional Advances
inferred← citeshttps://doi.org/10.1007/978-81-322-2794-6_1openalex-snapshot
Introduction to the Global Scenario of Marine Sponge Research
inferred← citeshttps://doi.org/10.1007/978-94-007-6214-5_21openalex-snapshot
The Bitter Fruit with Sweet Health Benefits: A Comprehensive Synopsis of Recent Research Progress on Medicinal Properties of Momordica Charantia
inferred← citeshttps://doi.org/10.1007/978-981-10-6141-7_1openalex-snapshot
Role of Proteases in Breast Cancer
inferred← citeshttps://doi.org/10.1007/978-981-10-6141-7_4openalex-snapshot
The Role of Urinary Proteases in Bladder Cancer
inferred← citeshttps://doi.org/10.1007/978-981-13-7828-7_8openalex-snapshot
Thioamide-Containing Peptides and Proteins
inferred← citeshttps://doi.org/10.1007/978-981-15-2817-0_5openalex-snapshot
Microalgae as Nutraceutical for Achieving Sustainable Food Solution in Future
inferred← citeshttps://doi.org/10.1007/s00044-021-02761-2openalex-snapshot
Modulators of neurolysin: promising agents for the treatment of tumor and neurological diseases
inferred← citeshttps://doi.org/10.1007/s00216-018-1292-3openalex-snapshot
A fluorometric sensing method for sensitive detection of trypsin and its inhibitor based on gold nanoclusters and gold nanoparticles
inferred← citeshttps://doi.org/10.1007/s00249-021-01554-0openalex-snapshot
A novel assay based on pre-equilibrium titration curves for the determination of enzyme inhibitor binding kinetics
inferred← citeshttps://doi.org/10.1007/s00253-011-3834-xopenalex-snapshot
Microbial and fungal protease inhibitors—current and potential applications
inferred← citeshttps://doi.org/10.1007/s00441-021-03433-8openalex-snapshot
Proteolysis and inflammation of the kidney glomerulus
inferred← citeshttps://doi.org/10.1007/s00894-025-06303-0openalex-snapshot
Malaria parasite cysteine and aspartic proteases as key drug targets for antimalarial therapy
inferred← citeshttps://doi.org/10.1007/s10096-014-2075-1openalex-snapshot
Bacterial proteases: targets for diagnostics and therapy
inferred← citeshttps://doi.org/10.1007/s10787-026-02310-6openalex-snapshot
Vitamins impacting mental/physical well-being during viral pandemics: a mechanistic review based on COVID-19: a comprehensive review
inferred← citeshttps://doi.org/10.1007/s11030-020-10166-3openalex-snapshot
First structure–activity relationship analysis of SARS-CoV-2 virus main protease (Mpro) inhibitors: an endeavor on COVID-19 drug discovery
inferred← citeshttps://doi.org/10.1007/s11686-026-01402-1openalex-snapshot
Rhomboid Proteases in Plasmodium spp. : Biology, Functional Roles, and Therapeutic Potential
inferred← citeshttps://doi.org/10.1007/s11926-013-0350-2openalex-snapshot
Genetically Engineered Mouse Models Reveal the Importance of Proteases as Osteoarthritis Drug Targets
inferred← citeshttps://doi.org/10.1007/s12010-014-0826-1openalex-snapshot
Trypsin Inhibitor from Edible Mushroom Pleurotus floridanus Active against Proteases of Microbial Origin
inferred← citeshttps://doi.org/10.1007/s12018-011-9094-6openalex-snapshot
Cysteine Cathepsins: Markers and Therapy Targets in Lung Disorders
inferred← citeshttps://doi.org/10.1007/s13311-017-0575-2openalex-snapshot
Therapeutic Approaches for Zika Virus Infection of the Nervous System
inferred← citeshttps://doi.org/10.1007/s13596-020-00508-9openalex-snapshot
Matrix metalloproteinase inhibitors identified from Camellia sinensis for COVID-19 prophylaxis: an in silico approach
inferred← citeshttps://doi.org/10.1007/s13659-026-00598-zopenalex-snapshot
Tropical psychotria plants are a rich source for peptide inhibitors of human prolyl oligopeptidase
inferred← citeshttps://doi.org/10.1016/b978-0-08-100596-5.22466-9openalex-snapshot
Proteases as Digestive Aids
inferred← citeshttps://doi.org/10.1016/b978-0-08-101023-5.00015-7openalex-snapshot
Microalgal proteins for feed, food and health
inferred← citeshttps://doi.org/10.1016/b978-0-12-417150-3.00007-7openalex-snapshot
Discovery and Development of Prolylcarboxypeptidase Inhibitors for Cardiometabolic Disorders
inferred← citeshttps://doi.org/10.1016/b978-0-12-818168-3.00002-4openalex-snapshot
Potential roles of protease inhibitors in anticancer therapy
inferred← citeshttps://doi.org/10.1016/b978-0-323-85696-6.00004-4openalex-snapshot
“Omics” approaches to determine protease degradomes in complex biological matrices
inferred← citeshttps://doi.org/10.1016/b978-0-443-16032-5.00014-2openalex-snapshot
Role of tumor microenvironment in prostate cancer therapy resistance
inferred← citeshttps://doi.org/10.1016/b978-0-443-19135-0.00007-0openalex-snapshot
Amino acid transporters as drug targets in disease modification
inferred← citeshttps://doi.org/10.1016/b978-0-443-26635-5.00051-1openalex-snapshot
Bioinformatics and system biology approach for proteases induced cancer drug designing
inferred← citeshttps://doi.org/10.1016/b978-0-443-30098-1.00019-7openalex-snapshot
Therapeutics of animal-derived compounds in proteases-induced cancer
inferred← citeshttps://doi.org/10.1016/b978-0-444-63503-7.00003-6openalex-snapshot
Disruption of Protease Genes in Microbes for Production of Heterologous Proteins
inferred← citeshttps://doi.org/10.1016/bs.apar.2024.05.003openalex-snapshot
Unveiling the peptidases of parasites from the office chair – The endothelin-converting enzyme case study
inferred← citeshttps://doi.org/10.1016/bs.apar.2024.07.001openalex-snapshot
Advances in protease inhibition-based chemotherapy: A decade of insights from Malaria research
inferred← citeshttps://doi.org/10.1016/j.ab.2013.09.022openalex-snapshot
Cleavage of pro-tumor necrosis factor alpha by ADAM metallopeptidase domain 17: A fluorescence-based protease assay cleaves its natural protein substrate
inferred← citeshttps://doi.org/10.1016/j.ab.2017.01.020openalex-snapshot
Acquisition of accurate data from intramolecular quenched fluorescence protease assays
inferred← citeshttps://doi.org/10.1016/j.abb.2025.110304openalex-snapshot
Unveiling the cyclopropyl appended acyl thiourea derivatives as antimicrobial, α-amylase and proteinase K inhibitors: Design, synthesis, biological evaluation, molecular docking, DFT and ADMET studies
inferred← citeshttps://doi.org/10.1016/j.abb.2026.110971openalex-snapshot
Natural metabolites from Tabebuia aurea reveal isoform-specific and cooperative modulation of cathepsins B and L
inferred← citeshttps://doi.org/10.1016/j.algal.2025.103925openalex-snapshot
Cyclic peptides from cyanobacteria: Structural insights, biological functions, and mechanisms of cyclization
inferred← citeshttps://doi.org/10.1016/j.bbapap.2015.04.029openalex-snapshot
Detection of protease activity in cells and animals
inferred← citeshttps://doi.org/10.1016/j.bcab.2015.11.007openalex-snapshot
Magnesium dependent proteinaceous protease inhibitor with pesticidal potential from alkali-halotolerant Streptomyces spp.: Optimization of production using statistical tools
inferred← citeshttps://doi.org/10.1016/j.bcp.2011.12.023openalex-snapshot
A selective reversible azapeptide inhibitor of human neutrophil proteinase 3 derived from a high affinity FRET substrate
inferred← citeshttps://doi.org/10.1016/j.biocel.2018.10.006openalex-snapshot
Therapeutic potential of targeting the Eph/ephrin signaling complex
inferred← citeshttps://doi.org/10.1016/j.biochi.2011.10.014openalex-snapshot
S1 pocket fingerprints of human and bacterial methionine aminopeptidases determined using fluorogenic libraries of substrates and phosphorus based inhibitors
inferred← citeshttps://doi.org/10.1016/j.biochi.2012.10.018openalex-snapshot
An integrated approach to the ligand binding specificity of Neisseria meningitidis M1 alanine aminopeptidase by fluorogenic substrate profiling, inhibitory studies and molecular modeling
inferred← citeshttps://doi.org/10.1016/j.biochi.2013.05.006openalex-snapshot
Toward very potent, non-covalent organophosphonate inhibitors of cathepsin C and related enzymes by 2-amino-1-hydroxy-alkanephosphonates dipeptides
inferred← citeshttps://doi.org/10.1016/j.biochi.2015.09.035openalex-snapshot
Activity profiling of aminopeptidases in cell lysates using a fluorogenic substrate library
inferred← citeshttps://doi.org/10.1016/j.biochi.2015.10.017openalex-snapshot
Current trends and challenges in proteomic identification of protease substrates
inferred← citeshttps://doi.org/10.1016/j.biochi.2019.03.013openalex-snapshot
Imaging of extracellular cathepsin S activity by a selective near infrared fluorescence substrate-based probe
inferred← citeshttps://doi.org/10.1016/j.biochi.2019.04.021openalex-snapshot
Application of nanotechnology to target and exploit tumour associated proteases
inferred← citeshttps://doi.org/10.1016/j.bioorg.2025.109323openalex-snapshot
Review of peptidomimetic vinyl sulfones targeting cysteine proteases and proteasomes
inferred← citeshttps://doi.org/10.1016/j.biopha.2024.117605openalex-snapshot
Fully human monoclonal antibody targeting the cysteine-rich substrate-interacting region of ADAM17 on cancer cells
inferred← citeshttps://doi.org/10.1016/j.bios.2012.12.061openalex-snapshot
A simple and general approach to assay protease activity with electrochemical technique
inferred← citeshttps://doi.org/10.1016/j.bios.2014.04.050openalex-snapshot
Turn-on chemiluminescent sensing platform for label-free protease detection using streptavidin-modified magnetic beads
inferred← citeshttps://doi.org/10.1016/j.bios.2025.117193openalex-snapshot
Mitigating dithiothreitol interference to gold/thiol interface in electrochemical detection of cathepsin B activity toward multiplex protease analysis
inferred← citeshttps://doi.org/10.1016/j.biotechadv.2025.108602openalex-snapshot
Protease engineering: Approaches, tools, and emerging trends
inferred← citeshttps://doi.org/10.1016/j.bmc.2020.115612openalex-snapshot
Synthesis of 2-guanidinyl pyridines and their trypsin inhibition and docking
inferred← citeshttps://doi.org/10.1016/j.bmc.2020.115756openalex-snapshot
Ahp-Cyclodepsipeptides as tunable inhibitors of human neutrophil elastase and kallikrein 7: Total synthesis of tutuilamide A, serine protease selectivity profile and comparison with lyngbyastatin 7
inferred← citeshttps://doi.org/10.1016/j.bmc.2020.115827openalex-snapshot
Design, synthesis and stepwise optimization of nitrile-based inhibitors of cathepsins B and L
inferred← citeshttps://doi.org/10.1016/j.bmc.2020.115860openalex-snapshot
Protease targeted COVID-19 drug discovery and its challenges: Insight into viral main protease (Mpro) and papain-like protease (PLpro) inhibitors
inferred← citeshttps://doi.org/10.1016/j.bmcl.2018.10.027openalex-snapshot
Corrigendum to “Design, synthesis, biological evaluation, and molecular docking of chalcone derivatives as anti-inflammatory agents” [Bioorg. Med. Chem. Lett. 27 (3) (2017) 602–606]
inferred← citeshttps://doi.org/10.1016/j.bpj.2022.05.023openalex-snapshot
An internal docking site stabilizes substrate binding to γ-secretase: Analysis by molecular dynamics simulations
inferred← citeshttps://doi.org/10.1016/j.cbpa.2020.09.009openalex-snapshot
New strategies to identify protease substrates
inferred← citeshttps://doi.org/10.1016/j.ccr.2026.217834openalex-snapshot
Design strategies and recent advances in activatable small molecule therapeutics
inferred← citeshttps://doi.org/10.1016/j.cell.2013.10.053openalex-snapshot
Proteolysis inside the Membrane Is a Rate-Governed Reaction Not Driven by Substrate Affinity
inferred← citeshttps://doi.org/10.1016/j.chembiol.2011.08.014openalex-snapshot
Selective and Cell-Active Inhibitors of the USP1/ UAF1 Deubiquitinase Complex Reverse Cisplatin Resistance in Non-small Cell Lung Cancer Cells
inferred← citeshttps://doi.org/10.1016/j.chembiol.2012.02.007openalex-snapshot
Discovery of Specific Inhibitors of Human USP7/HAUSP Deubiquitinating Enzyme
inferred← citeshttps://doi.org/10.1016/j.chembiol.2012.05.013openalex-snapshot
Identification of Exosite-Targeting Inhibitors of Anthrax Lethal Factor by High-Throughput Screening
inferred← citeshttps://doi.org/10.1016/j.chembiol.2017.09.007openalex-snapshot
General and Modular Strategy for Designing Potent, Selective, and Pharmacologically Compliant Inhibitors of Rhomboid Proteases
inferred← citeshttps://doi.org/10.1016/j.chembiol.2019.02.020openalex-snapshot
Late-Stage Conversion of Diphenylphosphonate to Fluorophosphonate Probes for the Investigation of Serine Hydrolases
inferred← citeshttps://doi.org/10.1016/j.chembiol.2019.07.001openalex-snapshot
Activation of Caspase-6 Is Promoted by a Mutant Huntingtin Fragment and Blocked by an Allosteric Inhibitor Compound
inferred← citeshttps://doi.org/10.1016/j.chembiol.2020.08.001openalex-snapshot
Controlled Inhibition of Apoptosis by Photoactivatable Caspase Inhibitors
inferred← citeshttps://doi.org/10.1016/j.chembiol.2023.01.001openalex-snapshot
Investigation of osteoclast cathepsin K activity in osteoclastogenesis and bone loss using a set of chemical reagents
inferred← citeshttps://doi.org/10.1016/j.chembiol.2023.09.009openalex-snapshot
An N terminomics toolbox combining 2-pyridinecarboxaldehyde probes and click chemistry for profiling protease specificity
inferred← citeshttps://doi.org/10.1016/j.chempr.2022.09.017openalex-snapshot
Widespread Microbial Utilization of Ribosomal β-Amino Acid-Containing Peptides and Proteins
inferred← citeshttps://doi.org/10.1016/j.csbj.2021.11.016openalex-snapshot
Novel dynamic residue network analysis approaches to study allosteric modulation: SARS-CoV-2 M pro and its evolutionary mutations as a case study
inferred← citeshttps://doi.org/10.1016/j.drudis.2012.06.017openalex-snapshot
Targeting mutant huntingtin for the development of disease-modifying therapy
inferred← citeshttps://doi.org/10.1016/j.drudis.2013.05.010openalex-snapshot
Pharmaceutical agents from filamentous marine cyanobacteria
inferred← citeshttps://doi.org/10.1016/j.drudis.2019.05.026openalex-snapshot
Peptide-based protease inhibitors from plants
inferred← citeshttps://doi.org/10.1016/j.drudis.2022.03.011openalex-snapshot
Exploiting protease activation for therapy
inferred← citeshttps://doi.org/10.1016/j.drudis.2023.103554openalex-snapshot
Peptide modulators of cell migration: Overview, applications and future development
inferred← citeshttps://doi.org/10.1016/j.ejca.2014.10.020openalex-snapshot
High expression of the cysteine proteinase legumain in colorectal cancer – Implications for therapeutic targeting
inferred← citeshttps://doi.org/10.1016/j.ejca.2020.09.017openalex-snapshot
Drug repositioning of antiretroviral ritonavir for combinatorial therapy in glioblastoma
inferred← citeshttps://doi.org/10.1016/j.ejmcr.2025.100311openalex-snapshot
Discovery of highly potent α-keto ester-based peptidomimetic inhibitors of the Hip1 protease for the treatment of Mycobacterium tuberculosis
inferred← citeshttps://doi.org/10.1016/j.ejmech.2014.02.059openalex-snapshot
A new method for filtering of reactive “warheads” of transition-state analog protease inhibitors
inferred← citeshttps://doi.org/10.1016/j.ejmech.2021.113294openalex-snapshot
Protease targeted COVID-19 drug discovery: What we have learned from the past SARS-CoV inhibitors?
inferred← citeshttps://doi.org/10.1016/j.ejmech.2021.113584openalex-snapshot
Improved SARS-CoV-2 Mpro inhibitors based on feline antiviral drug GC376: Structural enhancements, increased solubility, and micellar studies
inferred← citeshttps://doi.org/10.1016/j.ejmech.2024.116704openalex-snapshot
Covalent small-molecule inhibitors of SARS-CoV-2 Mpro: Insights into their design, classification, biological activity, and binding interactions
inferred← citeshttps://doi.org/10.1016/j.ejmech.2025.118144openalex-snapshot
Mitigating SARS-CoV-2–exacerbated neuroinflammation and Alzheimer's pathology: Synthesis of quinoline-based dual inhibitors targeting cysteine and aspartyl proteases
inferred← citeshttps://doi.org/10.1016/j.ejmech.2025.118260openalex-snapshot
Recent advances in patented inhibitors targeting serine proteases in inflammatory diseases
inferred← citeshttps://doi.org/10.1016/j.ejmech.2026.118779openalex-snapshot
Medicinal chemistry strategies targeting viral proteases: From classical design to next-generation therapeutics
inferred← citeshttps://doi.org/10.1016/j.exppara.2015.05.016openalex-snapshot
Natural products as inhibitors of recombinant cathepsin L of Leishmania mexicana
inferred← citeshttps://doi.org/10.1016/j.exppara.2017.02.007openalex-snapshot
Efficacy of protease inhibitor from marine Streptomyces sp. VITBVK2 against Leishmania donovani – An in vitro study
inferred← citeshttps://doi.org/10.1016/j.febslet.2012.06.015openalex-snapshot
Comparative analysis of the substrate preferences of two post‐proline cleaving endopeptidases, prolyl oligopeptidase and fibroblast activation protein α
inferred← citeshttps://doi.org/10.1016/j.foodchem.2014.01.024openalex-snapshot
Quantitative determination of active Bowman-Birk isoinhibitors, IBB1 and IBBD2, in commercial soymilks
inferred← citeshttps://doi.org/10.1016/j.gene.2014.05.055openalex-snapshot
Cloning, characterization, expression analysis and inhibition studies of a novel gene encoding Bowman–Birk type protease inhibitor from rice bean
inferred← citeshttps://doi.org/10.1016/j.heliyon.2020.e04647openalex-snapshot
Study of the structural, chemical descriptors and optoelectronic properties of the drugs Hydroxychloroquine and Azithromycin
inferred← citeshttps://doi.org/10.1016/j.inoche.2019.107456openalex-snapshot
Fabrication of gold nanoparticle@protease for cancer therapy and disinfection
inferred← citeshttps://doi.org/10.1016/j.jbc.2023.105614openalex-snapshot
New insight into the agonism of protease-activated receptors as an immunotherapeutic strategy
inferred← citeshttps://doi.org/10.1016/j.jbc.2026.111450openalex-snapshot
PRSS23 promotes ovarian cancer peritoneal dissemination independent of protease activity
inferred← citeshttps://doi.org/10.1016/j.jconrel.2025.114269openalex-snapshot
Engineering unnatural amino acids in peptide linkers enables cathepsin-selective antibody-drug conjugates for HER2-positive breast cancer
inferred← citeshttps://doi.org/10.1016/j.jep.2021.114237openalex-snapshot
In-vivo anti-plasmodial activity of phosphate buffer extract of Calotropis procera latex in mice infected with Plasmodium berghei
inferred← citeshttps://doi.org/10.1016/j.jmb.2011.07.028openalex-snapshot
The Binding Mechanism of a Peptidic Cyclic Serine Protease Inhibitor
inferred← citeshttps://doi.org/10.1016/j.jmb.2012.06.006openalex-snapshot
X-ray Crystal Structure and Specificity of the Plasmodium falciparum Malaria Aminopeptidase PfM18AAP
inferred← citeshttps://doi.org/10.1016/j.jmb.2015.08.005openalex-snapshot
Selection of High-Affinity Peptidic Serine Protease Inhibitors with Increased Binding Entropy from a Back-Flip Library of Peptide–Protease Fusions
inferred← citeshttps://doi.org/10.1016/j.jmb.2016.11.031openalex-snapshot
Large-Scale Structure-Based Prediction and Identification of Novel Protease Substrates Using Computational Protein Design
inferred← citeshttps://doi.org/10.1016/j.jmb.2017.09.011openalex-snapshot
Tripodal Lipoprotein Variants with C-Terminal Hydrophobic Residues Allosterically Modulate Activity of the DegP Protease
inferred← citeshttps://doi.org/10.1016/j.jmb.2021.167003openalex-snapshot
N-Terminal Finger Stabilizes the S1 Pocket for the Reversible Feline Drug GC376 in the SARS-CoV-2 Mpro Dimer
inferred← citeshttps://doi.org/10.1016/j.jmb.2025.169206openalex-snapshot
Sequence and Structure at Play in Designing Allosteric Drugs and Alleviating the Drug Resistance
inferred← citeshttps://doi.org/10.1016/j.jmgm.2020.107826openalex-snapshot
Understanding the mechanism of HIV-1 protease inhibition by monoclonal antibodies
inferred← citeshttps://doi.org/10.1016/j.jprot.2017.05.027openalex-snapshot
Intensity fading MALDI-TOF mass spectrometry and functional proteomics assignments to identify protease inhibitors in marine invertebrates
inferred← citeshttps://doi.org/10.1016/j.lfs.2019.01.015openalex-snapshot
Leishmanicidal therapy targeted to parasite proteases
inferred← citeshttps://doi.org/10.1016/j.mam.2022.101106openalex-snapshot
Cathepsin S (CTSS) activity in health and disease - A treasure trove of untapped clinical potential
inferred← citeshttps://doi.org/10.1016/j.mam.2022.101144openalex-snapshot
Diagnostic and therapeutic potential of protease inhibition
inferred← citeshttps://doi.org/10.1016/j.mam.2022.101150openalex-snapshot
Cysteine cathepsins: A long and winding road towards clinics
inferred← citeshttps://doi.org/10.1016/j.medj.2023.12.004openalex-snapshot
Olgotrelvir, a dual inhibitor of SARS-CoV-2 Mpro and cathepsin L, as a standalone antiviral oral intervention candidate for COVID-19
inferred← citeshttps://doi.org/10.1016/j.molcel.2015.12.022openalex-snapshot
Crystal Structures and Inhibition Kinetics Reveal a Two-Stage Catalytic Mechanism with Drug Design Implications for Rhomboid Proteolysis
inferred← citeshttps://doi.org/10.1016/j.molstruc.2021.130366openalex-snapshot
Unmasking of crucial structural fragments for coronavirus protease inhibitors and its implications in COVID-19 drug discovery
inferred← citeshttps://doi.org/10.1016/j.molstruc.2022.132652openalex-snapshot
In silico detection of potential inhibitors from vitamins and their derivatives compounds against SARS-CoV-2 main protease by using molecular docking, molecular dynamic simulation and ADMET profiling
inferred← citeshttps://doi.org/10.1016/j.oraloncology.2015.12.005openalex-snapshot
Threonine Aspartase1: An unexplored protease with relevance for oral oncology?
inferred← citeshttps://doi.org/10.1016/j.peptides.2012.01.003openalex-snapshot
Identification and molecular cloning of a novel amphibian Bowman Birk-type trypsin inhibitor from the skin of the Hejiang Odorous Frog; Odorrana hejiangensis
inferred← citeshttps://doi.org/10.1016/j.pharmthera.2018.05.011openalex-snapshot
Therapeutic targeting of cathepsin C: from pathophysiology to treatment
showing the first 200 of 581 · page through all 581
Editorial review for independent work. ICSAC — the Institute for Complexity
Science and Advanced Computing — runs a structured editorial panel for researchers
publishing outside journals, and publishes on CiteStamp rails. Submission is free
and goes through ORCID: icsacinstitute.org/submit.