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Putting chirality to work: the strategy of chiral switches

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1001/archinte.144.6.1143openalex-snapshot
A double-blind clinical trial in weight control. Use of fenfluramine and phentermine alone and in combination
inferredcites →https://doi.org/10.1001/jama.281.17.1580-aopenalex-snapshot
Electronic "Orange Book"
inferredcites →https://doi.org/10.1002/(sici)1099-1492(199604)9:2<72::aid-nbm406>3.0.co;2-3openalex-snapshot
Effect of Gossypol on Cultured TM3 Leydig and TM4 Sertoli Cells: 31P and 23Na NMR Study
inferredcites →https://doi.org/10.1002/(sici)1520-636x(2000)12:3<114::aid-chir3>3.0.co;2-nopenalex-snapshot
Parity violation and the evolution of biomolecular homochirality
inferredcites →https://doi.org/10.1002/1098-2299(200007/08)50:3/4<211::aid-ddr3>3.0.co;2-gopenalex-snapshot
Dexanabinol (HU-211): A nonpsychotropic cannabinoid with neuroprotective properties
inferredcites →https://doi.org/10.1002/3527600361.ch13openalex-snapshot
International Regulation of Chiral Drugs
inferredcites →https://doi.org/10.1002/9780470147313.ch1openalex-snapshot
Molecular Chirality
inferredcites →https://doi.org/10.1002/ange.19800920105openalex-snapshot
Chromatographische Racemattrennung
inferredcites →https://doi.org/10.1002/chir.530040513openalex-snapshot
FDA'S policy statement for the development of new stereoisomeric drugs
inferredcites →https://doi.org/10.1002/chir.530070109openalex-snapshot
Stereospecific determination, chiral inversion in vitro and pharmacokinetics in humans of the enantiomers of thalidomide
inferredcites →https://doi.org/10.1002/hup.336openalex-snapshot
Enantiomeric antidepressant drugs should be considered on individual merit
inferredcites →https://doi.org/10.1002/hup.340openalex-snapshot
An introduction to the ?enantiomer debate?
inferredcites →https://doi.org/10.1002/med.2610100102openalex-snapshot
Omeprazole: The first proton pump inhibitor
inferredcites →https://doi.org/10.1007/bf00484049openalex-snapshot
1.3 Organische Analyse
inferredcites →https://doi.org/10.1007/bf00541922openalex-snapshot
Stereochemistry, a basis for sophisticated nonsense in pharmacokinetics and clinical pharmacology
inferredcites →https://doi.org/10.1007/s00103-005-1024-7openalex-snapshot
Arzneimittelforschung
inferredcites →https://doi.org/10.1016/0016-7037(95)90151-5openalex-snapshot
Stereochemistry of organic compounds
inferredcites →https://doi.org/10.1016/0024-3205(74)90345-2openalex-snapshot
A selective inhibitor of serotonin uptake: Lilly 110140, 3-(p-Trifluoromethylphenoxy)-n-methyl-3-phenylpropylamine
inferredcites →https://doi.org/10.1016/0165-6147(85)90017-3openalex-snapshot
X-ray crystallography and drug action
inferredcites →https://doi.org/10.1016/s0040-4020(01)98529-1openalex-snapshot
The total synthesis of strychnine
inferredcites →https://doi.org/10.1016/s0040-4039(01)00296-9openalex-snapshot
Synthesis of ent -19-nortestosterone from its naturally occurring antipode
inferredcites →https://doi.org/10.1016/s0065-2490(96)80003-7openalex-snapshot
Stereochemical aspects of drug action and disposition
inferredcites →https://doi.org/10.1016/s0140-6736(00)02047-xopenalex-snapshot
Chiral switches
inferredcites →https://doi.org/10.1016/s0165-0173(01)00126-6openalex-snapshot
Recent developments in structure–activity relationships for steroid modulators of GABAA receptors
inferredcites →https://doi.org/10.1016/s0378-4347(00)83781-0openalex-snapshot
Resolution of the enantiomers of omeprazole and some of its analogues by liquid chromatography on a trisphenylcarbamoylcellulose-based stationary phase
inferredcites →https://doi.org/10.1016/s1062-1458(97)89579-7openalex-snapshot
Appetite-suppressant drugs and the risk of primary pulmonary hypertension
inferredcites →https://doi.org/10.1016/s1359-6446(97)01010-6openalex-snapshot
Stereoselectivity of drug action
inferredcites →https://doi.org/10.1016/s1359-6446(97)01017-9openalex-snapshot
Stereochemistry: handling interactions
inferredcites →https://doi.org/10.1016/s1359-6446(99)01363-xopenalex-snapshot
Intellectual property and chirality of drugs
inferredcites →https://doi.org/10.1021/cen-v076n030.p011aopenalex-snapshot
Nova acquires Huntsman's styrenics business
inferredcites →https://doi.org/10.1021/cen-v079n020.p045openalex-snapshot
CHIRAL CHEMISTRY
inferredcites →https://doi.org/10.1021/cen-v080n023.p043openalex-snapshot
CHIRAL ROUNDUP
inferredcites →https://doi.org/10.1021/jm00402a027openalex-snapshot
The absolute configurations and pharmacological activities of the optical isomers of fluoxetine, a selective serotonin-uptake inhibitor
inferredcites →https://doi.org/10.1021/tx9801817openalex-snapshot
Chiral Inversion and Hydrolysis of Thalidomide: Mechanisms and Catalysis by Bases and Serum Albumin, and Chiral Stability of Teratogenic Metabolites
inferredcites →https://doi.org/10.1034/j.1398-9995.2001.00204.xopenalex-snapshot
Comparison of the effects of levocetirizine and loratadine on histamine‐induced wheal, flare, and itch in human skin
inferredcites →https://doi.org/10.1038/215296a0openalex-snapshot
Toxicity and Teratogenicity of Optical Isomers of Thalidomide
inferredcites →https://doi.org/10.1038/clpt.1992.68openalex-snapshot
Introduction
inferredcites →https://doi.org/10.1038/clpt.1992.76openalex-snapshot
Long-term weight control study: Conclusions
inferredcites →https://doi.org/10.1038/nrd1038openalex-snapshot
The painful reality
inferredcites →https://doi.org/10.1038/nrd766openalex-snapshot
Structural proteomics
inferredcites →https://doi.org/10.1039/c39860000125openalex-snapshot
Acid activation of (H + –K + )-ATPase inhibiting 2-(2-pyridylmethyl-sulphinyl)benzimidazoles: isolation and characterization of the thiophilic ‘active principle’ and its reactions
inferredcites →https://doi.org/10.1055/s-2006-961512openalex-snapshot
On the Botanical Distribution of Chiral Forms of Gossypol
inferredcites →https://doi.org/10.1056/nejm199608293350901openalex-snapshot
Appetite-Suppressant Drugs and the Risk of Primary Pulmonary Hypertension
inferredcites →https://doi.org/10.1056/nejm199708283370901openalex-snapshot
Valvular Heart Disease Associated with Fenfluramine–Phentermine
inferredcites →https://doi.org/10.1088/0031-9112/7/1/002openalex-snapshot
Patents for Inventions
inferredcites →https://doi.org/10.1093/law/9780199571857.003.0017openalex-snapshot
Intellectual Property
inferredcites →https://doi.org/10.1093/milmed/151.1.386openalex-snapshot
Goodman and Gilman's the Pharmacological Basis of Therapeutics
inferredcites →https://doi.org/10.1093/oso/9780199684731.001.0001openalex-snapshot
Patents for Chemicals, Pharmaceuticals, and Biotechnology
inferredcites →https://doi.org/10.1093/rpc/47.9.289openalex-snapshot
IN THE MATTER OF I. G. FARBENINDUSTRIE A. G.'S PATENTS
inferredcites →https://doi.org/10.1097/00003246-200203000-00009openalex-snapshot
Dexanabinol (HU-211) in the treatment of severe closed head injury: A randomized, placebo-controlled, phase II clinical trial*
inferredcites →https://doi.org/10.1111/j.2042-7158.1983.tb02874.xopenalex-snapshot
The metabolic chiral inversion of 2-arylpropionic acids—a novel route with pharmacological consequences
inferredcites →https://doi.org/10.1111/j.2042-7166.2002.tb05480.xopenalex-snapshot
Goodman and Gilman's the Pharmacological Basis of Therapeutics
inferredcites →https://doi.org/10.1161/01.cir.99.1.156openalex-snapshot
Aminorex to Fen/Phen
inferredcites →https://doi.org/10.1177/009286159703100303openalex-snapshot
Development of Stereoisomers (Chiral) Drugs: A Brief Review Of Scientific and Regulatory Considerations
inferredcites →https://doi.org/10.1345/1542-6270(2002)036<0655:efapd>2.0.co;2openalex-snapshot
Esomeprazole for Acid Peptic Disorders
inferredcites →https://doi.org/10.1351/pac199668122193openalex-snapshot
Basic terminology of stereochemistry (IUPAC Recommendations 1996)
inferredcites →https://doi.org/10.1358/dof.1997.022.12.711853openalex-snapshot
Pharmacodynamics, pharmacokinetics and toxicity of ibuprofen enantiomers
inferredcites →https://doi.org/10.1358/dof.1999.024.01.483363openalex-snapshot
Bay-12-9566
inferredcites →https://doi.org/10.1358/dof.1999.024.11.559951openalex-snapshot
Esomeprazole Magnesium
inferredcites →https://doi.org/10.1378/chest.122.2.736openalex-snapshot
Two of a Kind
inferredcites →https://doi.org/10.1517/13543784.7.12.2027openalex-snapshot
Levalbuterol hydrochloride
inferredcites →https://doi.org/10.1517/13543784.8.6.861openalex-snapshot
Levobupivacaine: a new safer long acting local anaesthetic agent
inferredcites →https://doi.org/10.1517/14656566.1.1.109openalex-snapshot
Levofloxacin
inferredcites →https://doi.org/10.2165/00002018-200225030-00002openalex-snapshot
Cardiac and CNS Toxicity of Levobupivacaine
inferredcites →https://doi.org/10.2165/00003088-200140040-00002openalex-snapshot
Clinical Pharmacokinetics of Dexketoprofen
inferredcites →https://doi.org/10.2165/00003495-199448060-00002openalex-snapshot
Prospects for Pharmacological Male Contraception
inferredcites →https://doi.org/10.2165/00003495-200060020-00006openalex-snapshot
Esomeprazole
inferredcites →https://doi.org/10.3138/ctr.98.fmopenalex-snapshot
EDITORIA

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Evaluation of Trials Comparing Single-Enantiomer Drugs to Their Racemic Precursors
inferred← citeshttps://doi.org/10.1002/0471266949.bmc016.pub2openalex-snapshot
Chirality and Biological Activity
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The Drug Discovery Process
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Enzymes, Enolate Reductases “Old Yellow Enzyme”
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Drug Discovery: Small Molecule Drugs
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High‐Throughput Screening and Method Development Strategies to Separate Chiral Drug Compounds in HPLC, SFC, and CE
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Effects of Chirality on Toxicity
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Peroral Toxicity
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Stereochemical Elements Associated with Drug Metabolism and Toxicity
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Techniques to Facilitate the Performance of Mass Spectrometry: Sample Preparation, Liquid Chromatography, and Non‐Mass‐Spectrometric Detection
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Role of Stereochemistry in Drug Discrimination Studies
inferred← citeshttps://doi.org/10.1002/9781118075647.ch1openalex-snapshot
Overview of Chirality and Chiral Drugs
inferred← citeshttps://doi.org/10.1002/9781118075647.ch8openalex-snapshot
Pharmacology of Chiral Drugs
inferred← citeshttps://doi.org/10.1002/9781118075647.ch9openalex-snapshot
Pharmacokinetics of Chiral Drugs
inferred← citeshttps://doi.org/10.1002/9781118274408.ch10openalex-snapshot
Old Drugs Yield New Discoveries: Examples from the Prodrug, Chiral Switch, and Site‐Selective Deuteration Strategies
inferred← citeshttps://doi.org/10.1002/9781118339558.ch08openalex-snapshot
Biologically Mediated Chiral Inversion of Emerging Contaminants
inferred← citeshttps://doi.org/10.1002/9781118596784.ssd054openalex-snapshot
Chiral Chromatographic Methods in the Analysis and Purification of Enantiomers
inferred← citeshttps://doi.org/10.1002/9781119640929.ch4openalex-snapshot
Chemoenzymatic Synthesis of Pharmacologically Active Compounds Containing Chiral 1,2‐Amino Alcohol Moiety
inferred← citeshttps://doi.org/10.1002/9783527619580.ch35openalex-snapshot
The Unique Role of Halogen Substituents in the Design of Modern Crop Protection Compounds
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The Development of an Environmentally Sustainable Process for Radafaxine
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Tapentadol – From Morphine and Tramadol to the Discovery of Tapentadol
inferred← citeshttps://doi.org/10.1002/9783527655908.ch4openalex-snapshot
The Unique Role of Halogen Substituents in the Design of Modern Crop Protection Compounds
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Atropisomerism in Drug Discovery and Development
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Chirality of Metal Nanoparticles in Chiral Mesoporous Silica
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Hierarchical Porous Homochiral Metal‐Organic Frameworks for Enantiomeric Separation of Chiral Drugs
inferred← citeshttps://doi.org/10.1002/adma.200305682openalex-snapshot
Photofabrication of Superhelix‐Like Patterns on Azobenzene Polymer Films
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Chiral Supraparticles for Controllable Nanomedicine
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Recent Advances in Ultrathin Chiral Metasurfaces by Twisted Stacking
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Chiral‐Selective Antigen‐Presentation by Supramolecular Chiral Polymer Micelles
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Toward Enhancing Chiro‐Optical and Magneto‐Optical Properties of Magnetic Nanocrystals by Surface Plasmons
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Observation of Wide Bandwidth and Giant Chiroptical Response Empowered by Core–Shell Micro‐Helixes
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Bimetallic Ru/Ru‐Catalyzed Asymmetric One‐Pot Sequential Hydrogenations for the Stereodivergent Synthesis of Chiral Lactones
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Stereodivergent Access to Aliphatic Nitro Compounds Bearing Multi‐Contiguous Stereocenters via Sequential Catalysis
inferred← citeshttps://doi.org/10.1002/ajoc.201900004openalex-snapshot
Advances in Asymmetric Di‐and Trifluoromethylthiolation, and Di‐ and Trifluoromethoxylation Reactions
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Accessing all Four Stereoisomers of β ‐Fluoroamines by Engineered Imine Reductase‐Mediated Dynamic Kinetic Reductive Amination
inferred← citeshttps://doi.org/10.1002/ange.200901719openalex-snapshot
Atropisomerie als Herausforderung in der Medikamentenentwicklung
inferred← citeshttps://doi.org/10.1002/ange.200902997openalex-snapshot
Gleichzeitige Bindung beider Enantiomere eines racemischen Wirkstoffs durch das aktive Zentrum eines Enzyms
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Industrielle Anwendungen der Diels‐Alder‐Reaktion
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Organomediated Enantioselective 18F Fluorination for PET Applications
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Conformational Studies and Atropisomerism Kinetics of the ALK Clinical Candidate Lorlatinib (PF‐06463922) and Desmethyl Congeners
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Totalsynthese und Untersuchung der biologischen Aktivität von (−)‐Artemisinin – die Antimalaria‐Aktivität von Artemisinin ist nicht stereospezifisch
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Design and Application of Peptide‐Mimic Phosphonium Salt Catalysts in Asymmetric Synthesis
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A Nuclearity‐Dependent Enantiodivergent Epoxide Opening via Enthalpy‐Controlled Mononuclear and Entropy‐Controlled Dinuclear (Salen)Titanium Catalysis
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Asymmetric Synthesis of Chiral Calix[4]arenes with Both Inherent and Axial Chirality via Cobalt‐Catalyzed Enantioselective Intermolecular C−H Annulation
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Recent Advances on Catalytic Atroposelective Synthesis of Planar‐Chiral Macrocycles
inferred← citeshttps://doi.org/10.1002/ange.202413047openalex-snapshot
A Multiresponsive Ferrocene‐Based Chiral Overcrowded Alkene Twisting Liquid Crystals
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Catalytic Asymmetric Synthesis of Chiral Caged Hydrocarbons as Arenes Bioisosteres
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The Challenge of Atropisomerism in Drug Discovery
inferred← citeshttps://doi.org/10.1002/anie.200902997openalex-snapshot
The Active Site of an Enzyme Can Host Both Enantiomers of a Racemic Ligand Simultaneously
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Industrial Applications of the Diels–Alder Reaction
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Organomediated Enantioselective 18F Fluorination for PET Applications
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Conformational Studies and Atropisomerism Kinetics of the ALK Clinical Candidate Lorlatinib (PF‐06463922) and Desmethyl Congeners
inferred← citeshttps://doi.org/10.1002/anie.201802015openalex-snapshot
Total Synthesis and Biological Investigation of (−)‐Artemisinin: The Antimalarial Activity of Artemisinin Is not Stereospecific
inferred← citeshttps://doi.org/10.1002/anie.202307258openalex-snapshot
Design and Application of Peptide‐Mimic Phosphonium Salt Catalysts in Asymmetric Synthesis
inferred← citeshttps://doi.org/10.1002/anie.202309525openalex-snapshot
A Nuclearity‐Dependent Enantiodivergent Epoxide Opening via Enthalpy‐Controlled Mononuclear and Entropy‐Controlled Dinuclear (Salen)Titanium Catalysis
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Asymmetric Synthesis of Chiral Calix[4]arenes with Both Inherent and Axial Chirality via Cobalt‐Catalyzed Enantioselective Intermolecular C−H Annulation
inferred← citeshttps://doi.org/10.1002/anie.202412805openalex-snapshot
Recent Advances on Catalytic Atroposelective Synthesis of Planar‐Chiral Macrocycles
inferred← citeshttps://doi.org/10.1002/anie.202413047openalex-snapshot
A Multiresponsive Ferrocene‐Based Chiral Overcrowded Alkene Twisting Liquid Crystals
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Catalytic Asymmetric Synthesis of Chiral Caged Hydrocarbons as Arenes Bioisosteres
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Synthesis of hyperbranched polycarbosilane modified with cyclodextrin derivatives and its application in coated capillary electrophoresis columns
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Organic‐Inorganic Hybrid Materials for Efficient Enantioseparation Using Cellulose 3,5‐Dimethylphenylcarbamate and Tetraethyl Orthosilicate
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Novel Chiral 1,3,4‐Oxadiazole Derivatives Inducing Astrocyte Differentiation of Rat Fetal Neural Stem Cells
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Chiral separation of the β2‐sympathomimetic fenoterol by HPLC and capillary zone electrophoresis for pharmacokinetic studies
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Enantiomeric separation of meptazinol and its three intermediate enantiomers by capillary electrophoresis: quantitative analysis of meptazinol in pharmaceutical formulations
inferred← citeshttps://doi.org/10.1002/cctc.201500006openalex-snapshot
Ruthenium‐Catalyzed Highly Chemoselective Hydrogenation of Aldehydes
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Enzyme‐Modified Particles for Selective Biocatalytic Hydrogenation by Hydrogen‐Driven NADH Recycling
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Highly Efficient Access to (S)‐Sulfoxides Utilizing a Promiscuous Flavoprotein Monooxygenase in a Whole‐Cell Biocatalyst Format
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Synthesis of 4‐Hydroxy‐4‐Phenylbutyric Acid Derivatives via Sequential Photocatalytic Decarboxylative Radical Addition and Enzymatic Reduction
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Hybrid Flow Bioreactor with All Catalysts Immobilized for Enzymatic Electrosynthesis
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Catalytic Deuteration of Amines in Water (D 2 O) With Ir, Ru, and Rh Pentamethylcyclopentadienyl Dioxime Complexes
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Improvement of a Stereoselective Biocatalytic Synthesis by Substrate and Enzyme Engineering: 2‐Hydroxy‐(4′‐oxocyclohexyl)acetonitrile as the Model
inferred← citeshttps://doi.org/10.1002/chem.201003526openalex-snapshot
Induction of Molecular Chirality by Circularly Polarized Light in Cyclic Azobenzene with a Photoswitchable Benzene Rotor
inferred← citeshttps://doi.org/10.1002/chem.201202651openalex-snapshot
Enantiomerization Mechanism of Thalidomide and the Role of Water and Hydroxide Ions
inferred← citeshttps://doi.org/10.1002/chem.201402777openalex-snapshot
pH‐Controlled Multiple Chiral Inversion That Induces Molecular Dimerization in a Gold(I)–Cobalt(III) Coordination System with L ‐Cysteinate
inferred← citeshttps://doi.org/10.1002/chem.201603022openalex-snapshot
Stereoselective Ketone Rearrangements with Hypervalent Iodine Reagents
inferred← citeshttps://doi.org/10.1002/chem.201705301openalex-snapshot
A Highly Enantioselective Copper/Phosphoramidite‐Thioether‐Catalyzed Diastereodivergent 1,3‐Dipolar Cycloaddition of Azomethine Ylides and Nitroalkenes
inferred← citeshttps://doi.org/10.1002/chem.201904382openalex-snapshot
Photoracemization‐Based Viedma Ripening of a BINOL Derivative
inferred← citeshttps://doi.org/10.1002/chem.201905707openalex-snapshot
Chiral Bent‐Shaped Molecules Exhibiting Unusually Wide Range of Blue Liquid‐Crystalline Phases and Multistimuli‐Responsive Behavior
inferred← citeshttps://doi.org/10.1002/chem.202200741openalex-snapshot
Photochemical Deracemization of a Medicinally‐Relevant Benzopyran using an Oscillatory Flow Reactor
inferred← citeshttps://doi.org/10.1002/chem.202304364openalex-snapshot
Biocatalysis in Non‐Conventional Media: Unlocking the Potential for Sustainable Chiral Amine Synthesis
inferred← citeshttps://doi.org/10.1002/chir.10274openalex-snapshot
Facing chirality in the 21st century: Approaching the challenges in the pharmaceutical industry
inferred← citeshttps://doi.org/10.1002/chir.20049openalex-snapshot
Probability rule for chiral recognition
inferred← citeshttps://doi.org/10.1002/chir.20160openalex-snapshot
Reversal of elution order for profen acid enantiomers in packed‐column SFC on Chiralpak AD
inferred← citeshttps://doi.org/10.1002/chir.20214openalex-snapshot
Conformational spaces of the gastrointestinal antisecretory chiral drug omeprazole: Stereochemistry and tautomerism
inferred← citeshttps://doi.org/10.1002/chir.20224openalex-snapshot
Tracking of enantioselective solubility of rac‐norgestrel in the presence of cyclodextrin by a CD spectroscopic method
inferred← citeshttps://doi.org/10.1002/chir.20399openalex-snapshot
Enantiomeric separation and determination of absolute stereochemistry of asymmetric molecules in drug discovery—Building chiral technology toolboxes
inferred← citeshttps://doi.org/10.1002/chir.20417openalex-snapshot
Pyramidal inversion mechanism of simple chiral and achiral sulfoxides: A theoretical study
inferred← citeshttps://doi.org/10.1002/chir.20520openalex-snapshot
A consideration of the patentability of enantiomers in the pharmaceutical industry in the United States
inferred← citeshttps://doi.org/10.1002/chir.20546openalex-snapshot
Stereoselective disposition of S‐ and R‐licarbazepine in mice
inferred← citeshttps://doi.org/10.1002/chir.20633openalex-snapshot
Direct high‐performance liquid chromatographic separation of the enantiomers of venlafaxine and 11 analogs using amylose‐derived chiral stationary phases
inferred← citeshttps://doi.org/10.1002/chir.20813openalex-snapshot
Electrostatic chiral distinction: Tetrahedral model dimers
inferred← citeshttps://doi.org/10.1002/chir.20839openalex-snapshot
Racemization of the gastrointestinal antisecretory chiral drug esomeprazole magnesium via the pyramidal inversion mechanism: A theoretical study
inferred← citeshttps://doi.org/10.1002/chir.20898openalex-snapshot
Chiral separation of neonicotinoid insecticides by polysaccharide‐type stationary phases using high‐performance liquid chromatography and supercritical fluid chromatography
inferred← citeshttps://doi.org/10.1002/chir.22304openalex-snapshot
Single Enantiomer Versus Racemate: Chiral Distinction in the Proton Pump Inhibitors Omeprazole and Esomeprazole
inferred← citeshttps://doi.org/10.1002/chir.22501openalex-snapshot
Classroom Enters the Courtroom: Stereochemistry of SN1 and SN2 Reactions in Enantiomer Patent Litigations of the Antidepressant Escitalopram
inferred← citeshttps://doi.org/10.1002/chir.22690openalex-snapshot
Evaluation of the chiral recognition properties and the column performances of three chiral stationary phases based on cellulose for the enantioseparation of six dihydropyridines by high‐performance liquid chromatography
inferred← citeshttps://doi.org/10.1002/chir.22696openalex-snapshot
Preparative chiral separation and absolute configuration of the synthetic pterocarpanquinone LQB‐118
inferred← citeshttps://doi.org/10.1002/chir.22728openalex-snapshot
Reliable HPLC separation, vibrational circular dichroism spectra, and absolute configurations of isoborneol enantiomers
inferred← citeshttps://doi.org/10.1002/chir.23067openalex-snapshot
Method for determination of optical purity of 2‐arylpropanoic acids using urea derivatives based on a 1,1′‐binaphthalene skeleton as chiral NMR solvating agents: Advantages and limitations thereof
inferred← citeshttps://doi.org/10.1002/chir.23200openalex-snapshot
Stereochemical facets of clinical β‐blockers: An overview
inferred← citeshttps://doi.org/10.1002/chir.23260openalex-snapshot
Enantiopure ethyl 2,3‐dibromopropionate: Enantioselective synthesis vs preparative HPLC enantioseparation of racemate on multigram scale
inferred← citeshttps://doi.org/10.1002/chir.23313openalex-snapshot
Multigram‐scale HPLC enantioseparation as a rescue pathway for circumventing racemization problem during enantioselective synthesis of ethyl 3,4‐dihydro‐2H‐1,4‐benzoxazine‐2‐carboxylate
inferred← citeshttps://doi.org/10.1002/chir.23416openalex-snapshot
Solvent‐dependent helix inversion in optically active poly(diphenylacetylene)s and their chiral recognition abilities as chiral stationary phases for high‐performance liquid chromatography
inferred← citeshttps://doi.org/10.1002/chir.23627openalex-snapshot
Lipase mediated new chemo‐enzymatic synthesis of ( RS )‐, ( R )‐, and ( S )‐bunolol
inferred← citeshttps://doi.org/10.1002/chir.70133openalex-snapshot
Rethinking Chiral Decision‐Making in Pharmaceutical Analysis: The Emerging Role of Artificial Intelligence
inferred← citeshttps://doi.org/10.1002/cjoc.200590757openalex-snapshot
Chiral Fluorescent Receptors Based on (R)‐1,1′‐Binaphthylene‐2,2′‐bisthiourea: Synthesis and Chiral Recognition
inferred← citeshttps://doi.org/10.1002/cjoc.200690074openalex-snapshot
Enantiospecific Synthesis of Penehyclidine Hydrochloride and Its Piperidine Derivatives with R Configuration
inferred← citeshttps://doi.org/10.1002/cjoc.200690258openalex-snapshot
Sensitive Method for Enantioseparation of Rivastigmine with Highly Sulfated Cyclodextrin as Chiral Selector by Capillary Electrophoresis
inferred← citeshttps://doi.org/10.1002/cjoc.202100018openalex-snapshot
New Amines and Activation Modes in Asymmetric Aminocatalysis
inferred← citeshttps://doi.org/10.1002/cmdc.201000485openalex-snapshot
Revealing Atropisomer Axial Chirality in Drug Discovery
inferred← citeshttps://doi.org/10.1002/cmdc.201300218openalex-snapshot
Chemical, Pharmacological, and in vitro Metabolic Stability Studies on Enantiomerically Pure RC‐33 Compounds: Promising Neuroprotective Agents Acting as σ1 Receptor Agonists
inferred← citeshttps://doi.org/10.1002/cmdc.201900367openalex-snapshot
Chirality as an Important Factor for the Development of New Antiepileptic Drugs
inferred← citeshttps://doi.org/10.1002/cmdc.202300557openalex-snapshot
Enantioselective recognition, synthesis, and separation of pharmaceutical compounds at chiral metallic surfaces
inferred← citeshttps://doi.org/10.1002/cpdd.293openalex-snapshot
Stereo‐Psychopharmacology: The Case of Citalopram and Escitalopram
inferred← citeshttps://doi.org/10.1002/cphc.201402086openalex-snapshot
Chiral Discrimination in Dimers of Diphosphines PH2PH2 and PH2PHF
inferred← citeshttps://doi.org/10.1002/cphc.201800897openalex-snapshot
In situ Second‐Harmonic Generation Circular Dichroism with Submonolayer Sensitivity
inferred← citeshttps://doi.org/10.1002/cphc.202000493openalex-snapshot
Speeding up Viedma Deracemization through Water‐catalyzed and Reactant Self‐catalyzed Racemization
inferred← citeshttps://doi.org/10.1002/ejic.200800899openalex-snapshot
Biomimetic Modelling of Copper Enzymes: Synthesis, Characterization, EPR Analysis and Enantioselective Catalytic Oxidations by a New Chiral Trinuclear Copper(II) Complex
inferred← citeshttps://doi.org/10.1002/ejoc.200400006openalex-snapshot
Desymmetrization of Prochiral Phosphanes Using Derivatives of (−)‐Cytisine
inferred← citeshttps://doi.org/10.1002/ejoc.201201055openalex-snapshot
Carica papaya Lipase Catalysed Resolution of β‐Amino Esters for the Highly Enantioselective Synthesis of (S)‐Dapoxetine
inferred← citeshttps://doi.org/10.1002/ejoc.201402673openalex-snapshot
DMAP‐Catalysed Sulfinylation of Diacetone‐ D ‐Glucose: Improved Method for the Synthesis of Enantiopure tert‐Butyl Sulfoxides and tert‐Butanesulfinamides
inferred← citeshttps://doi.org/10.1002/ejoc.201700645openalex-snapshot
Highly Regio‐ and Enantioselective γ‐Alkylation of Linear α,β‐Unsaturated Aldehydes
inferred← citeshttps://doi.org/10.1002/ejoc.202100311openalex-snapshot
Organocatalytic Enantioselective Intramolecular (Hetero)Michael Additions in Desymmetrization Processes
inferred← citeshttps://doi.org/10.1002/ejoc.202300738openalex-snapshot
Catalytic Enantioselective Synthesis of Inherently Chiral Molecules: Recent Advances
inferred← citeshttps://doi.org/10.1002/elan.201400405openalex-snapshot
Chiral Recognition of Proline Enantiomers by the Catalytic Oxygen Reduction and Formation of Cu(II)‐Polymer Complex Crystals
inferred← citeshttps://doi.org/10.1002/elps.200305744openalex-snapshot
Novel enantioselective strong cation exchangers based on sulfodipeptide selectors: Evaluation for enantiomer separation of chiral bases by nonaqueous capillary electrochromatography
inferred← citeshttps://doi.org/10.1002/elps.200405927openalex-snapshot
Enantioseparations by capillary electro‐chromatography: Differences exhibited by normal‐ and reversed‐phase versions of polysaccharide stationary phases
inferred← citeshttps://doi.org/10.1002/elps.200405928openalex-snapshot
Enantiomeric resolution of 2‐arylpropionic acid nonsteroidal anti‐inflammatory drugs by capillary electrophoresis: Methods and applications
inferred← citeshttps://doi.org/10.1002/elps.200410190openalex-snapshot
Separation strategy for acidic chiral pharmaceuticals with capillary electrochromatography on polysaccharide stationary phases
inferred← citeshttps://doi.org/10.1002/elps.201900144openalex-snapshot
Some thoughts about enantioseparations in capillary electrophoresis
inferred← citeshttps://doi.org/10.1002/elps.202100032openalex-snapshot
Chiral separation in the class of proton pump inhibitors by chromatographic and electromigration techniques: An overview
inferred← citeshttps://doi.org/10.1002/etc.3943openalex-snapshot
Ecotoxicological properties of ketoprofen and the S(+)-enantiomer (dexketoprofen): Bioassays in freshwater model species and biomarkers in fish PLHC-1 cell line
inferred← citeshttps://doi.org/10.1002/jcph.642openalex-snapshot
The Evergreening of Biopharmaceuticals: Time to Defoliate
inferred← citeshttps://doi.org/10.1002/jctb.5417openalex-snapshot
Enantioseparation with liquid membranes
inferred← citeshttps://doi.org/10.1002/jssc.200600009openalex-snapshot
Enantiomeric separation of chiral sulfoxides by supercritical fluid chromatography
inferred← citeshttps://doi.org/10.1002/jssc.200600282openalex-snapshot
Enantiomeric resolution of new triazole compounds by high‐performance liquid chromatography
inferred← citeshttps://doi.org/10.1002/jssc.201000762openalex-snapshot
Chiral HPLC separation and absolute configuration assignment of a series of new triazole compounds
inferred← citeshttps://doi.org/10.1002/jssc.201300419openalex-snapshot
Enantiomeric separation of proton pump inhibitors on new generation chiral columns using LC and supercritical fluid chromatography
inferred← citeshttps://doi.org/10.1002/jssc.201500217openalex-snapshot
Scope of partial least‐squares regression applied to the enantiomeric composition determination of ketoprofen from strongly overlapped chromatographic profiles
inferred← citeshttps://doi.org/10.1002/jssc.70538openalex-snapshot
Comparative Evaluation of Polar‐Organic HPLC, Reversed‐Phase HPLC, and Supercritical Fluid Chromatography for Enantioseparation and Gram‐Scale Purification of Meclizine and Buclizine
inferred← citeshttps://doi.org/10.1002/mrc.4634openalex-snapshot
Multiple homonuclear band‐selective decoupling NMR : Fast and unambiguous determination of diastereomeric excess
inferred← citeshttps://doi.org/10.1002/pca.760openalex-snapshot
An NMR method towards the routine chiral determination of natural products
inferred← citeshttps://doi.org/10.1002/slct.201700231openalex-snapshot
Direct Chiral Separation of Binaphthyl Derivatives Using Atroposelective Antibodies
inferred← citeshttps://doi.org/10.1002/slct.201802086openalex-snapshot
Homochiral Metal Organic Frameworks and Their Usage for the Enantio‐Purification of Racemic Drugs
inferred← citeshttps://doi.org/10.1002/smll.201601115openalex-snapshot
Circular Dichroism Studies on Plasmonic Nanostructures
inferred← citeshttps://doi.org/10.1002/sscp.202200131openalex-snapshot
Chirality: An inescapable concept for the pharmaceutical, bio‐pharmaceutical, food, and cosmetic industries
inferred← citeshttps://doi.org/10.1002/tcr.20107openalex-snapshot
Immobilized polysaccharide derivatives: chiral packing materials for efficient HPLC resolution
inferred← citeshttps://doi.org/10.1002/tee.23961openalex-snapshot
Vertical Contact‐Separation Process of Liquid Crystal Micro‐Droplets for Chirality Sensing Mechanism
inferred← citeshttps://doi.org/10.1007/3-540-26573-2_7openalex-snapshot
Structural Requirements for Cannabinoid Receptor Probes
inferred← citeshttps://doi.org/10.1007/978-1-4419-9485-1_7openalex-snapshot
Nonlinear Mixed Effects Models: Theory
inferred← citeshttps://doi.org/10.1007/978-1-62703-131-8_36openalex-snapshot
The Thalidomide Disaster, Lessons from the Past
inferred← citeshttps://doi.org/10.1007/978-3-0346-0226-6_18openalex-snapshot
Efficacy and Safety of Zopiclone and Eszopiclone in the Treatment of Primary and Comorbid Insomnia
inferred← citeshttps://doi.org/10.1007/978-3-319-61590-5_1openalex-snapshot
Introduction and Background Information
inferred← citeshttps://doi.org/10.1007/978-3-319-74914-3_1openalex-snapshot
Introduction
inferred← citeshttps://doi.org/10.1007/978-3-642-17393-6_1openalex-snapshot
Introduction and Background Information
inferred← citeshttps://doi.org/10.1007/978-981-15-5534-3_4openalex-snapshot
Dynamic Axial Chirality in Drug Design and Discovery: Introduction to Atropisomerism, Classification, Significance, Recent Trends and Challenges
inferred← citeshttps://doi.org/10.1007/s00204-025-04282-yopenalex-snapshot
Advances in the application of computational toxicology in cosmetic safety assessment
inferred← citeshttps://doi.org/10.1007/s00213-004-1865-zopenalex-snapshot
Escitalopram versus citalopram: the surprising role of the R-enantiomer
inferred← citeshttps://doi.org/10.1007/s00216-012-6365-0openalex-snapshot
Separation mechanism of chiral impurities, ephedrine and pseudoephedrine, found in amphetamine-type substances using achiral modifiers in the gas phase
inferred← citeshttps://doi.org/10.1007/s00216-012-6487-4openalex-snapshot
Enantioselective analysis of zopiclone in rat brain by liquid chromatography tandem mass spectrometry
inferred← citeshttps://doi.org/10.1007/s00216-026-06565-4openalex-snapshot
Enantioseparation of proton pump inhibitors using multimodal chiral cation exchangers
inferred← citeshttps://doi.org/10.1007/s00449-012-0741-1openalex-snapshot
Isolation of enantioselective α-hydroxyacid dehydrogenases based on a high-throughput screening method
inferred← citeshttps://doi.org/10.1007/s10126-008-9145-2openalex-snapshot
Characterization and its Potential Application of Two Esterases Derived from the Arctic Sediment Metagenome
inferred← citeshttps://doi.org/10.1007/s10337-022-04171-xopenalex-snapshot
Preparation and Evaluation of a Ferrocenediamide Bridge bis(β-Cyclodextrin)-Bonded Chiral Stationary Phase for HPLC
inferred← citeshttps://doi.org/10.1007/s10450-006-0568-7openalex-snapshot
Interpretation of chromatographic retentions of simple solutes with an amylose-based sorbent using infrared spectroscopy and DFT modeling
inferred← citeshttps://doi.org/10.1007/s10822-017-0090-xopenalex-snapshot
Learning epistatic interactions from sequence-activity data to predict enantioselectivity
inferred← citeshttps://doi.org/10.1007/s10847-012-0123-yopenalex-snapshot
Chiral calix[4]arenes bearing α-hydroxy amide units as membrane carriers for amino acid methyl esters
inferred← citeshttps://doi.org/10.1007/s10895-007-0268-zopenalex-snapshot
Determination of Enantiomeric Compositions of Analytes Using Novel Fluorescent Chiral Molecular Micelles and Steady State Fluorescence Measurements
inferred← citeshttps://doi.org/10.1007/s11030-025-11439-5openalex-snapshot
Exploring the impacts of flavonoid compounds on escitalopram metabolism: a combined in vitro and in vivo study
inferred← citeshttps://doi.org/10.1007/s11419-018-0453-6openalex-snapshot
Use of polysaccharide-based chiral columns: enantiomeric separation of seven pairs of abused drugs by high-performance liquid chromatography–mass spectrometry
inferred← citeshttps://doi.org/10.1007/s11426-025-2923-9openalex-snapshot
Chiral macrocyclic membranes for efficient enantioselective separation
inferred← citeshttps://doi.org/10.1007/s12272-020-01277-4openalex-snapshot
Structure elucidation of small organic molecules by contemporary computational chemistry methods
inferred← citeshttps://doi.org/10.1007/s41061-018-0184-5openalex-snapshot
Analysis of US FDA-Approved Drugs Containing Sulfur Atoms
inferred← citeshttps://doi.org/10.1016/b0-08-045044-x/00054-7openalex-snapshot
Chiral Drug Discovery and Development – From Concept Stage to Market Launch
inferred← citeshttps://doi.org/10.1016/b0-12-369397-7/00084-4openalex-snapshot
CHIROPTICAL ANALYSIS
inferred← citeshttps://doi.org/10.1016/b978-0-12-409547-2.00077-9openalex-snapshot
Chiroptical Analysis
inferred← citeshttps://doi.org/10.1016/b978-0-12-821062-8.00001-6openalex-snapshot
Chiral analytical chemistry
inferred← citeshttps://doi.org/10.1016/b978-0-12-822248-5.00005-xopenalex-snapshot
Characterizing the environmentally benign nature of chemical processes
inferred← citeshttps://doi.org/10.1016/b978-0-12-824010-6.00046-0openalex-snapshot
Proprietary strategies in precision medicine
inferred← citeshttps://doi.org/10.1016/b978-0-32-390644-9.00046-9openalex-snapshot
Industrial Applications of Asymmetric Synthesis in a Medicinal Chemistry Setting
inferred← citeshttps://doi.org/10.1016/b978-0-323-89855-3.00006-6openalex-snapshot
Sustainable chemical and biological technologies for the production of enantiopure added-value molecules in biorefineries
inferred← citeshttps://doi.org/10.1016/b978-0-323-91760-5.00011-7openalex-snapshot
Extending the reach of computational approaches to model enzyme catalysis
inferred← citeshttps://doi.org/10.1016/b978-0-443-19057-5.00008-xopenalex-snapshot
Industrial asymmetric biocatalysis
inferred← citeshttps://doi.org/10.1016/b978-0-444-56369-9.00022-8openalex-snapshot
Crystallization of Chiral Molecules
inferred← citeshttps://doi.org/10.1016/b978-0-444-64027-7.00021-5openalex-snapshot
Chiral Analysis and Separation Using Molecular Rotation
inferred← citeshttps://doi.org/10.1016/b978-0-444-64070-3.00009-6openalex-snapshot
Recent developments in liquid and supercritical fluid chromatographic enantioseparations
inferred← citeshttps://doi.org/10.1016/bs.coac.2025.01.001openalex-snapshot
Chiral pharmaceuticals in environmental samples
inferred← citeshttps://doi.org/10.1016/j.aca.2005.04.039openalex-snapshot
Identification of chiral selectors for improved enantioseparation based on molecular interaction fields
inferred← citeshttps://doi.org/10.1016/j.aca.2006.05.065openalex-snapshot
Liquid chromatography–tandem mass spectrometry in chiral study of amlodipine biotransformation in rat hepatocytes
inferred← citeshttps://doi.org/10.1016/j.actbio.2023.12.020openalex-snapshot
Suicide gene delivery by morphology-adaptable enantiomeric peptide assemblies for combined ovarian cancer therapy
inferred← citeshttps://doi.org/10.1016/j.aquatox.2020.105677openalex-snapshot
Novel organ-specific effects of Ketoprofen and its enantiomer, dexketoprofen on toxicological response transcripts and their functional products in salmon
inferred← citeshttps://doi.org/10.1016/j.bbrc.2013.09.107openalex-snapshot
The (R)-enantiomer of CE3F4 is a preferential inhibitor of human exchange protein directly activated by cyclic AMP isoform 1 (Epac1)
inferred← citeshttps://doi.org/10.1016/j.bbrc.2020.08.046openalex-snapshot
Brave new world revisited: Focus on nanomedicine
inferred← citeshttps://doi.org/10.1016/j.bioorg.2007.07.002openalex-snapshot
Eudismic analysis of tricyclic sesquiterpenoid alcohols: Lead structures for the design of potent inhibitors of the human UDP-glucuronosyltransferase 2B7
inferred← citeshttps://doi.org/10.1016/j.bioorg.2018.08.033openalex-snapshot
Stereoisomeric guaiacylglycerol-β-coniferyl aldehyde ether induces distinctive apoptosis by downregulation of MEK/ERK pathway in hepatocellular carcinoma cells
inferred← citeshttps://doi.org/10.1016/j.bioorg.2020.104147openalex-snapshot
Sesquineolignan and neolignan enantiomers from Triadica sebifera
inferred← citeshttps://doi.org/10.1016/j.bioorg.2021.104751openalex-snapshot
Asymmetric synthesis and in vivo/in vitro characterization of new hybrid anticonvulsants derived from (2,5-dioxopyrrolidin-1-yl)phenylacetamides
inferred← citeshttps://doi.org/10.1016/j.biortech.2023.129851openalex-snapshot
Biosynthesis of chiral diols from alkenes using metabolically engineered type II methanotroph
inferred← citeshttps://doi.org/10.1016/j.bmc.2005.09.013openalex-snapshot
Inhibition of O-GlcNAcase by PUGNAc is dependent upon the oxime stereochemistry
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