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The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism
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2 of the 158 references listed on this page are in the Retraction Watch database as retracted (export 2026-10-28): 10.1002/ijc.20711 (notice 2019-05-06), 10.1074/jbc.m305602200 (notice 2017-03-02).
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Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1002/(sici)1098-2264(199805)22:1<79::aid-gcc11>3.0.co;2-dopenalex-snapshot
DNA gains in 3q occur frequently in squamous cell carcinoma of the lung, but not in adenocarcinoma
inferredcites →https://doi.org/10.1002/(sici)1098-2744(199802)21:2<81::aid-mc1>3.3.co;2-kopenalex-snapshot
Amplification and overexpression of the AKT2 oncogene in a subset of human pancreatic ductal adenocarcinomas
inferredcites →https://doi.org/10.1002/ijc.10962openalex-snapshot
Frequent monoallelic deletion of PTEN and its reciprocal associatioin with PIK3CA amplification in gastric carcinoma
inferredcites →https://doi.org/10.1002/ijc.20711openalex-snapshot
Retracted: Frequent genetic and biochemical alterations of the PI 3‐K/AKT/PTEN pathway in head and neck squamous cell carcinoma
inferredcites →https://doi.org/10.1002/ijc.2910640412openalex-snapshot
Molecular alterations of the AKT2 oncogene in ovarian and breast carcinomas
inferredcites →https://doi.org/10.1002/j.1460-2075.1993.tb05867.xopenalex-snapshot
A membrane‐associated complex containing the Vps15 protein kinase and the Vps34 PI 3‐kinase is essential for protein sorting to the yeast lysosome‐like vacuole.
inferredcites →https://doi.org/10.1002/path.1207openalex-snapshot
Genomic gain of PIK3CA and increased expression of p110alpha are associated with progression of dysplasia into invasive squamous cell carcinoma
inferredcites →https://doi.org/10.1007/s00401-005-1000-1openalex-snapshot
PIK3CA mutations in glioblastoma multiforme
inferredcites →https://doi.org/10.1007/s004280050477openalex-snapshot
Allelic losses on chromosome arm 10q and mutation of the PTEN ( MMAC1 ) tumour suppressor gene in primary and metastatic malignant melanomas
inferredcites →https://doi.org/10.1016/0092-8674(91)90650-nopenalex-snapshot
A novel protein kinase homolog essential for protein sorting to the yeast lysosome-like vacuole
inferredcites →https://doi.org/10.1016/0092-8674(93)90404-eopenalex-snapshot
SH2 domains recognize specific phosphopeptide sequences
inferredcites →https://doi.org/10.1016/j.biochi.2004.10.019openalex-snapshot
Positive and negative regulation of insulin signaling through IRS-1 phosphorylation
inferredcites →https://doi.org/10.1016/j.ccr.2005.05.014openalex-snapshot
Mutant PIK3CA promotes cell growth and invasion of human cancer cells
inferredcites →https://doi.org/10.1016/j.ceb.2005.09.009openalex-snapshot
Growing roles for the mTOR pathway
inferredcites →https://doi.org/10.1016/j.cell.2004.08.028openalex-snapshot
Temporal Control of Differentiation by the Insulin Receptor/Tor Pathway in Drosophila
inferredcites →https://doi.org/10.1016/j.cell.2006.03.035openalex-snapshot
A Pharmacological Map of the PI3-K Family Defines a Role for p110α in Insulin Signaling
inferredcites →https://doi.org/10.1016/j.cmet.2006.04.003openalex-snapshot
Loss of class IA PI3K signaling in muscle leads to impaired muscle growth, insulin response, and hyperlipidemia
inferredcites →https://doi.org/10.1016/j.cmet.2006.04.005openalex-snapshot
Divergent regulation of hepatic glucose and lipid metabolism by phosphoinositide 3-kinase via Akt and PKCλ/ζ
inferredcites →https://doi.org/10.1016/j.cub.2005.02.020openalex-snapshot
p84, a New Gβγ-Activated Regulatory Subunit of the Type IB Phosphoinositide 3-Kinase p110γ
inferredcites →https://doi.org/10.1016/j.ejca.2005.04.022openalex-snapshot
The prevalence of PIK3CA mutations in gastric and colon cancer
inferredcites →https://doi.org/10.1016/j.semcdb.2003.12.021openalex-snapshot
Human cancer, PTEN and the PI-3 kinase pathway
inferredcites →https://doi.org/10.1016/j.semcdb.2003.12.022openalex-snapshot
PDK1, the master regulator of AGC kinase signal transduction
inferredcites →https://doi.org/10.1016/j.semcdb.2003.12.023openalex-snapshot
PI3-kinase and TOR: PIKTORing cell growth
inferredcites →https://doi.org/10.1016/j.tem.2005.03.010openalex-snapshot
FoxO proteins in insulin action and metabolism
inferredcites →https://doi.org/10.1016/j.tibs.2004.11.003openalex-snapshot
Restraining PI3K: mTOR signalling goes back to the membrane
inferredcites →https://doi.org/10.1016/s0092-8674(00)80187-7openalex-snapshot
The Gβγ Sensitivity of a PI3K Is Dependent upon a Tightly Associated Adaptor, p101
inferredcites →https://doi.org/10.1016/s0092-8674(00)80405-5openalex-snapshot
Akt Phosphorylation of BAD Couples Survival Signals to the Cell-Intrinsic Death Machinery
inferredcites →https://doi.org/10.1016/s0092-8674(00)81382-3openalex-snapshot
Serine Phosphorylation of Death Agonist BAD in Response to Survival Factor Results in Binding to 14-3-3 Not BCL-XL
inferredcites →https://doi.org/10.1016/s0092-8674(02)00969-8openalex-snapshot
Regulation of Myocardial Contractility and Cell Size by Distinct PI3K-PTEN Signaling Pathways
inferredcites →https://doi.org/10.1016/s0092-8674(04)00452-0openalex-snapshot
FoxOs at the Crossroads of Cellular Metabolism, Differentiation, and Transformation
inferredcites →https://doi.org/10.1016/s0092-8674(05)80084-4openalex-snapshot
Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r)
inferredcites →https://doi.org/10.1016/s0962-8924(02)00042-9openalex-snapshot
Insulin/IGF and target of rapamycin signaling: a TOR de force in growth control
inferredcites →https://doi.org/10.1016/s0968-0004(00)01543-7openalex-snapshot
Phosphoinositide signaling and the regulation of membrane trafficking in yeast
inferredcites →https://doi.org/10.1016/s1074-7613(01)00134-0openalex-snapshot
T Cell-Specific Loss of Pten Leads to Defects in Central and Peripheral Tolerance
inferredcites →https://doi.org/10.1016/s1097-2765(00)00006-xopenalex-snapshot
14-3-3 Proteins and Survival Kinases Cooperate to Inactivate BAD by BH3 Domain Phosphorylation
inferredcites →https://doi.org/10.1016/s1097-2765(00)80303-2openalex-snapshot
The C. elegans PTEN Homolog, DAF-18, Acts in the Insulin Receptor-like Metabolic Signaling Pathway
inferredcites →https://doi.org/10.1016/s1097-2765(01)00191-5openalex-snapshot
The Class II Phosphoinositide 3-Kinase C2α Is Activated by Clathrin and Regulates Clathrin-Mediated Membrane Trafficking
inferredcites →https://doi.org/10.1016/s1097-2765(02)00568-3openalex-snapshot
Identification of the Tuberous Sclerosis Complex-2 Tumor Suppressor Gene Product Tuberin as a Target of the Phosphoinositide 3-Kinase/Akt Pathway
inferredcites →https://doi.org/10.1016/s1535-6108(03)00215-0openalex-snapshot
Prostate-specific deletion of the murine Pten tumor suppressor gene leads to metastatic prostate cancer
inferredcites →https://doi.org/10.1038/315239a0openalex-snapshot
Association of phosphatidylinositol kinase activity with polyoma middle-T competent for transformation
inferredcites →https://doi.org/10.1038/35041700openalex-snapshot
Genetic pathways that regulate ageing in model organisms
inferredcites →https://doi.org/10.1038/366461a0openalex-snapshot
A C. elegans mutant that lives twice as long as wild type
inferredcites →https://doi.org/10.1038/414799aopenalex-snapshot
Insulin signalling and the regulation of glucose and lipid metabolism
inferredcites →https://doi.org/10.1038/bjc.1998.674openalex-snapshot
Mutation and expression analysis of the putative prostate tumour-suppressor gene PTEN
inferredcites →https://doi.org/10.1038/nature01137openalex-snapshot
A central role for JNK in obesity and insulin resistance
inferredcites →https://doi.org/10.1038/nature02866openalex-snapshot
Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity
inferredcites →https://doi.org/10.1038/nature04694openalex-snapshot
Critical role for the p110α phosphoinositide-3-OH kinase in growth and metabolic regulation
inferredcites →https://doi.org/10.1038/ncb839openalex-snapshot
TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling
inferredcites →https://doi.org/10.1038/ncb840openalex-snapshot
Akt regulates growth by directly phosphorylating Tsc2
inferredcites →https://doi.org/10.1038/ng0497-356openalex-snapshot
Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers
inferredcites →https://doi.org/10.1038/ng782openalex-snapshot
Deletion of Pten in mouse brain causes seizures, ataxia and defects in soma size resembling Lhermitte-Duclos disease
inferredcites →https://doi.org/10.1038/nm1052openalex-snapshot
mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways
inferredcites →https://doi.org/10.1038/nm1111openalex-snapshot
Possible novel therapy for diabetes with cell-permeable JNK-inhibitory peptide
inferredcites →https://doi.org/10.1038/nrc1753openalex-snapshot
Oncogenic PI3K deregulates transcription and translation
inferredcites →https://doi.org/10.1038/nrc839openalex-snapshot
The phosphatidylinositol 3-Kinase–AKT pathway in human cancer
inferredcites →https://doi.org/10.1038/nrm1435openalex-snapshot
Chemotaxis: signalling the way forward
inferredcites →https://doi.org/10.1038/nrm1837openalex-snapshot
Critical nodes in signalling pathways: insights into insulin action
inferredcites →https://doi.org/10.1038/sj.bjc.6690115openalex-snapshot
Analysis of the 10q23 chromosomal region and the PTEN gene in human sporadic breast carcinoma
inferredcites →https://doi.org/10.1038/sj.bjc.6690121openalex-snapshot
Exclusion of a major role for the PTEN tumour-suppressor gene in breast carcinomas
inferredcites →https://doi.org/10.1038/sj.onc.1200205openalex-snapshot
Analysis of PTEN and the 10q23 region in primary prostate carcinomas
inferredcites →https://doi.org/10.1038/sj.onc.1201689openalex-snapshot
PTEN/MMAC1 mutations in primary glioblastomas and short-term cultures of malignant gliomas
inferredcites →https://doi.org/10.1038/sj.onc.1201756openalex-snapshot
PTEN mutations in gliomas and glioneuronal tumors
inferredcites →https://doi.org/10.1038/sj.onc.1201881openalex-snapshot
Identification of PTEN/MMAC1 alterations in uncultured melanomas and melanoma cell lines
inferredcites →https://doi.org/10.1038/sj.onc.1202081openalex-snapshot
PTEN/MMAC1/TEP1 involvement in primary prostate cancers
inferredcites →https://doi.org/10.1038/sj.onc.1203597openalex-snapshot
PIK3CA as an oncogene in cervical cancer
inferredcites →https://doi.org/10.1038/sj.onc.1208304openalex-snapshot
PIK3CA gene is frequently mutated in breast carcinomas and hepatocellular carcinomas
inferredcites →https://doi.org/10.1042/bst0310275openalex-snapshot
Phosphoinositide 3-kinase γ: a key modulator in inflammation and allergy
inferredcites →https://doi.org/10.1042/bst0320350openalex-snapshot
Physiological functions of protein kinase B/Akt
inferredcites →https://doi.org/10.1042/bst0320383openalex-snapshot
Phosphoinositide 3-kinase γ: kinase-dependent and -independent activities in cardiovascular function and disease
inferredcites →https://doi.org/10.1042/bst0320817openalex-snapshot
Analysis of insulin signalling by RNAi-based gene silencing
inferredcites →https://doi.org/10.1046/j.1523-1747.2000.00877.xopenalex-snapshot
Mutation and Allelic Loss of the PTEN/MMAC1 gene in Primary and Metastatic Melanoma Biopsies
inferredcites →https://doi.org/10.1056/nejmoa044238openalex-snapshot
EGFR Mutation and Resistance of Non–Small-Cell Lung Cancer to Gefitinib
inferredcites →https://doi.org/10.1073/pnas.0407396101openalex-snapshot
Reversible oxidation and inactivation of the tumor suppressor PTEN in cells stimulated with peptide growth factors
inferredcites →https://doi.org/10.1073/pnas.0408864102openalex-snapshot
Phosphatidylinositol 3-kinase mutations identified in human cancer are oncogenic
inferredcites →https://doi.org/10.1073/pnas.0409773102openalex-snapshot
ErbB-3 mediates phosphoinositide 3-kinase activity in gefitinib-sensitive non-small cell lung cancer cell lines
inferredcites →https://doi.org/10.1073/pnas.0506925102openalex-snapshot
Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase
inferredcites →https://doi.org/10.1073/pnas.0508988102openalex-snapshot
The oncogenic properties of mutant p110α and p110β phosphatidylinositol 3-kinases in human mammary epithelial cells
inferredcites →https://doi.org/10.1073/pnas.0604628103openalex-snapshot
Phosphoinositide 3-kinase regulatory subunit p85α suppresses insulin action via positive regulation of PTEN
inferredcites →https://doi.org/10.1073/pnas.171060098openalex-snapshot
An inhibitor of mTOR reduces neoplasia and normalizes p70/S6 kinase activity in Pten +/− mice
inferredcites →https://doi.org/10.1073/pnas.171076798openalex-snapshot
Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR
inferredcites →https://doi.org/10.1073/pnas.81.7.2117openalex-snapshot
Evidence that the Rous sarcoma virus transforming gene product phosphorylates phosphatidylinositol and diacylglycerol.
inferredcites →https://doi.org/10.1073/pnas.84.14.5034openalex-snapshot
Molecular cloning of the akt oncogene and its human homologues AKT1 and AKT2: amplification of AKT1 in a primary human gastric adenocarcinoma.
inferredcites →https://doi.org/10.1073/pnas.89.19.9267openalex-snapshot
AKT2, a putative oncogene encoding a member of a subfamily of protein-serine/threonine kinases, is amplified in human ovarian carcinomas.
inferredcites →https://doi.org/10.1073/pnas.93.8.3636openalex-snapshot
Amplification of AKT2 in human pancreatic cells and inhibition of AKT2 expression and tumorigenicity by antisense RNA.
inferredcites →https://doi.org/10.1073/pnas.95.9.5246openalex-snapshot
Inactivation of the tumor suppressor PTEN/MMAC1 in advanced human prostate cancer through loss of expression
inferredcites →https://doi.org/10.1074/jbc.273.22.13375openalex-snapshot
The Tumor Suppressor, PTEN/MMAC1, Dephosphorylates the Lipid Second Messenger, Phosphatidylinositol 3,4,5-Trisphosphate
inferredcites →https://doi.org/10.1074/jbc.273.46.30199openalex-snapshot
Regulation of the p85/p110α Phosphatidylinositol 3′-Kinase
inferredcites →https://doi.org/10.1074/jbc.275.12.9047openalex-snapshot
The c-Jun NH2-terminal Kinase Promotes Insulin Resistance during Association with Insulin Receptor Substrate-1 and Phosphorylation of Ser307
inferredcites →https://doi.org/10.1074/jbc.m204681200openalex-snapshot
The Identification of ATP-citrate Lyase as a Protein Kinase B (Akt) Substrate in Primary Adipocytes
inferredcites →https://doi.org/10.1074/jbc.m207866200openalex-snapshot
Insulin Receptor Substrate and p55 Orthologous Adaptor Proteins Function in the Caenorhabditis elegans daf-2/Insulin-like Signaling Pathway
inferredcites →https://doi.org/10.1074/jbc.m302094200openalex-snapshot
Use of RNA Interference-mediated Gene Silencing and Adenoviral Overexpression to Elucidate the Roles of AKT/Protein Kinase B Isoforms in Insulin Actions
inferredcites →https://doi.org/10.1074/jbc.m305602200openalex-snapshot
Positive and Negative Roles of p85α and p85β Regulatory Subunits of Phosphoinositide 3-Kinase in Insulin Signaling
inferredcites →https://doi.org/10.1074/jbc.m310405200openalex-snapshot
The Insulin-like Growth Factor 1 Receptor Induces Physiological Heart Growth via the Phosphoinositide 3-Kinase(p110α) Pathway
inferredcites →https://doi.org/10.1074/jbc.m506967200openalex-snapshot
Increased P85α Is a Potent Negative Regulator of Skeletal Muscle Insulin Signaling and Induces in Vivo Insulin Resistance Associated with Growth Hormone Excess
inferredcites →https://doi.org/10.1074/jbc.m507201200openalex-snapshot
hVps34 Is a Nutrient-regulated Lipid Kinase Required for Activation of p70 S6 Kinase
inferredcites →https://doi.org/10.1074/jbc.m512502200openalex-snapshot
Characterization of p87PIKAP, a Novel Regulatory Subunit of Phosphoinositide 3-Kinase γ That Is Highly Expressed in Heart and Interacts with PDE3B
inferredcites →https://doi.org/10.1083/jcb.130.4.781openalex-snapshot
Role for phosphatidylinositol 3-kinase in the sorting and transport of newly synthesized lysosomal enzymes in mammalian cells.
inferredcites →https://doi.org/10.1083/jcb.152.3.519openalex-snapshot
Two Distinct Vps34 Phosphatidylinositol 3–Kinase Complexes Function in Autophagy and Carboxypeptidase Y Sorting in Saccharomyces cerevisiae
inferredcites →https://doi.org/10.1083/jcb.200112050openalex-snapshot
Novel PtdIns(3)P-binding protein Etf1 functions as an effector of the Vps34 PtdIns 3-kinase in autophagy
inferredcites →https://doi.org/10.1083/jcb.200404150openalex-snapshot
A novel phosphatidylinositol(3,4,5)P3 pathway in fission yeast
inferredcites →https://doi.org/10.1083/jcb.200503088openalex-snapshot
The p85 regulatory subunit of phosphoinositide 3-kinase down-regulates IRS-1 signaling via the formation of a sequestration complex
inferredcites →https://doi.org/10.1093/emboj/19.11.2537openalex-snapshot
The conserved phosphoinositide 3‐kinase pathway determines heart size in mice
inferredcites →https://doi.org/10.1093/genetics/118.1.75openalex-snapshot
A mutation in the age-1 gene in Caenorhabditis elegans lengthens life and reduces hermaphrodite fertility.
inferredcites →https://doi.org/10.1093/jnci/93.16.1246openalex-snapshot
PTEN Mutation, EGFR Amplification, and Outcome in Patients With Anaplastic Astrocytoma and Glioblastoma Multiforme
inferredcites →https://doi.org/10.1097/00008390-200212000-00006openalex-snapshot
PTEN inactivation is rare in melanoma tumours but occurs frequently in melanoma cell lines
inferredcites →https://doi.org/10.1101/gad.1314605openalex-snapshot
Feedback inhibition of Akt signaling limits the growth of tumors lacking Tsc2
inferredcites →https://doi.org/10.1101/gad.239102openalex-snapshot
Lethality of Drosophila lacking TSC tumor suppressor function rescued by reducing dS6K signaling
inferredcites →https://doi.org/10.1111/j.1365-2990.2005.00660.xopenalex-snapshot
Genetic alteration and expression of the phosphoinositol‐3‐kinase/Akt pathway genes PIK3CA and PIKE in human glioblastomas
inferredcites →https://doi.org/10.1111/j.1749-6632.1995.tb26689.xopenalex-snapshot
The Role of the Insulin‐like Growth Factor‐I Receptor in Cancer
inferredcites →https://doi.org/10.1126/science.1065518openalex-snapshot
Negative Regulation of Neural Stem/Progenitor Cell Proliferation by the Pten Tumor Suppressor Gene in Vivo
inferredcites →https://doi.org/10.1126/science.1096502openalex-snapshot
High Frequency of Mutations of the PIK3CA Gene in Human Cancers
inferredcites →https://doi.org/10.1126/science.1096706openalex-snapshot
A Family with Severe Insulin Resistance and Diabetes Due to a Mutation in AKT2
inferredcites →https://doi.org/10.1126/science.1106148openalex-snapshot
Phosphorylation and Regulation of Akt/PKB by the Rictor-mTOR Complex
inferredcites →https://doi.org/10.1126/science.275.5300.665openalex-snapshot
Direct Regulation of the Akt Proto-Oncogene Product by Phosphatidylinositol-3,4-bisphosphate
inferredcites →https://doi.org/10.1126/science.275.5308.1943openalex-snapshot
PTEN , a Putative Protein Tyrosine Phosphatase Gene Mutated in Human Brain, Breast, and Prostate Cancer
inferredcites →https://doi.org/10.1126/science.276.5320.1848openalex-snapshot
Transformation of Chicken Cells by the Gene Encoding the Catalytic Subunit of PI 3-Kinase
inferredcites →https://doi.org/10.1126/science.278.5338.687openalex-snapshot
Interleukin-3-Induced Phosphorylation of BAD Through the Protein Kinase Akt
inferredcites →https://doi.org/10.1126/science.285.5436.2122openalex-snapshot
Impaired Fas Response and Autoimmunity in Pten +/− Mice
inferredcites →https://doi.org/10.1126/science.292.5522.1728openalex-snapshot
Insulin Resistance and a Diabetes Mellitus-Like Syndrome in Mice Lacking the Protein Kinase Akt2 (PKBβ)
inferredcites →https://doi.org/10.1126/science.296.5573.1655openalex-snapshot
The Phosphoinositide 3-Kinase Pathway
inferredcites →https://doi.org/10.1126/stke.2132003re16openalex-snapshot
Membrane Recognition and Targeting by Lipid-Binding Domains
inferredcites →https://doi.org/10.1128/jvi.64.10.4718-4725.1990openalex-snapshot
Production of novel polyphosphoinositides in vivo is linked to cell transformation by polyomavirus middle T antigen
inferredcites →https://doi.org/10.1128/mcb.17.1.338openalex-snapshot
A Specific Product of Phosphatidylinositol 3-Kinase Directly Activates the Protein Kinase Akt through Its Pleckstrin Homology Domain
inferredcites →https://doi.org/10.1128/mcb.18.3.1379openalex-snapshot
Regulation of the p85/p110 Phosphatidylinositol 3′-Kinase: Stabilization and Inhibition of the p110α Catalytic Subunit by the p85 Regulatory Subunit
inferredcites →https://doi.org/10.1128/mcb.22.8.2799-2809.2002openalex-snapshot
Akt/Protein Kinase B Promotes Organ Growth in Transgenic Mice
inferredcites →https://doi.org/10.1128/mcb.25.21.9491-9502.2005openalex-snapshot
Class I A Phosphoinositide 3-Kinase Regulates Heart Size and Physiological Cardiac Hypertrophy
inferredcites →https://doi.org/10.1128/mcb.25.5.1596-1607.2005openalex-snapshot
Phosphoinositide 3-Kinase Catalytic Subunit Deletion and Regulatory Subunit Deletion Have Opposite Effects on Insulin Sensitivity in Mice
inferredcites →https://doi.org/10.1128/mcb.25.6.2498-2510.2005openalex-snapshot
Insulin Hypersensitivity and Resistance to Streptozotocin-Induced Diabetes in Mice Lacking PTEN in Adipose Tissue
inferredcites →https://doi.org/10.1136/jmg.37.9.653openalex-snapshot
Identification of PTEN mutations in metastatic melanoma specimens
inferredcites →https://doi.org/10.1146/annurev.biochem.67.1.481openalex-snapshot
PHOSPHOINOSITIDE KINASES
inferredcites →https://doi.org/10.1146/annurev.cellbio.17.1.615openalex-snapshot
Cellular Function of Phosphoinositide 3-Kinases: Implications for Development, Immunity, Homeostasis, and Cancer
inferredcites →https://doi.org/10.1152/physiol.00007.2004openalex-snapshot
Unraveling the Cellular Mechanism of Insulin Resistance in Humans: New Insights from Magnetic Resonance Spectroscopy
inferredcites →https://doi.org/10.1152/physiol.00017.2005openalex-snapshot
Turning Signals On and Off: GLUT4 Traffic in the Insulin-Signaling Highway
inferredcites →https://doi.org/10.1158/0008-5472-can-04-3913openalex-snapshot
PIK3CA Mutations Correlate with Hormone Receptors, Node Metastasis, and ERBB2, and Are Mutually Exclusive with PTEN Loss in Human Breast Carcinoma
inferredcites →https://doi.org/10.1158/0008-5472.can-04-2933openalex-snapshot
Mutation of the PIK3CA Gene in Ovarian and Breast Cancer
inferredcites →https://doi.org/10.1158/0008-5472.can-05-2612openalex-snapshot
Breast Cancer–Associated PIK3CA Mutations Are Oncogenic in Mammary Epithelial Cells
inferredcites →https://doi.org/10.1158/0008-5472.can-05-2925openalex-snapshot
mTOR Inhibition Induces Upstream Receptor Tyrosine Kinase Signaling and Activates Akt
inferredcites →https://doi.org/10.1158/1078-0432.ccr-04-2142openalex-snapshot
Frequent Mutation of the PIK3CA Gene in Ovarian and Breast Cancers
inferredcites →https://doi.org/10.1159/000063469openalex-snapshot
Insulin and Insulin-Like Growth Factor I Receptors: Similarities and Differences in Signal Transduction
inferredcites →https://doi.org/10.1172/jci200422230openalex-snapshot
PKC-θ knockout mice are protected from fat-induced insulin resistance
inferredcites →https://doi.org/10.1182/blood-2002-06-1785openalex-snapshot
Common mechanism for oncogenic activation of MLL by forkhead family proteins
inferredcites →https://doi.org/10.1186/1471-2407-5-29openalex-snapshot
Mutations of PIK3CAin gastric adenocarcinoma
inferredcites →https://doi.org/10.1186/1475-4924-2-20openalex-snapshot
The Drosophila Forkhead transcription factor FOXO mediates the reduction in cell number associated with reduced insulin signaling
inferredcites →https://doi.org/10.1186/bcr1262openalex-snapshot
Somatic mutation and gain of copy number of PIK3CA in human breast cancer
inferredcites →https://doi.org/10.1189/jlb.1202629openalex-snapshot
Decisions on life and death: FOXO Forkhead transcription factors are in command when PKB/Akt is off duty
inferredcites →https://doi.org/10.1200/jco.2004.02.141openalex-snapshot
The Biology and Clinical Relevance of the PTEN Tumor Suppressor Pathway
inferredcites →https://doi.org/10.1210/en.2003-1297openalex-snapshot
Human Placental Growth Hormone Increases Expression of the P85 Regulatory Unit of Phosphatidylinositol 3-Kinase and Triggers Severe Insulin Resistance in Skeletal Muscle
inferredcites →https://doi.org/10.1210/jc.2004-0749openalex-snapshot
Reversal of Insulin Resistance Postpartum Is Linked to Enhanced Skeletal Muscle Insulin Signaling
inferredcites →https://doi.org/10.1210/jc.2004-2281openalex-snapshot
Uncommon Mutation, but Common Amplifications, of thePIK3CAGene in Thyroid Tumors
inferredcites →https://doi.org/10.1371/journal.pbio.0000020openalex-snapshot
Candidate Gene Association Study in Type 2 Diabetes Indicates a Role for Genes Involved in β-Cell Function as Well as Insulin Action
inferredcites →https://doi.org/10.1371/journal.pbio.0000059openalex-snapshot
Pten Dose Dictates Cancer Progression in the Prostate
inferredcites →https://doi.org/10.1677/erc.0.0080237openalex-snapshot
Prospects for phosphoinositide 3-kinase inhibition as a cancer treatment.
inferredcites →https://doi.org/10.2337/diab.46.3.494openalex-snapshot
Identification of a Common Amino Acid Polymorphism in the p85α Regulatory Subunit of Phosphatidylinositol 3-Kinase: Effects on Glucose Disappearance Constant, Glucose Effectiveness, and the Insulin Sensitivity Index
inferredcites →https://doi.org/10.2337/diabetes.54.8.2351openalex-snapshot
Increased p85/55/50 Expression and Decreased Phosphotidylinositol 3-Kinase Activity in Insulin-Resistant Human Skeletal Muscle
inferredcites →https://doi.org/10.4161/cbt.3.8.994openalex-snapshot
The PIK3CA gene is mutated with high frequency in human breast cancers
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
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Immunity Stress Responses and Low Growth Metabolism Levels are Implicated in Macrobrachium Rosenbergii Growth Retardation
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Spectrum of Somatic Cancer Gene Variations Among Adults With Appendiceal Cancer by Age
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Landscape of Phosphatidylinositol-3-Kinase Pathway Alterations Across 19 784 Diverse Solid Tumors
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p110α and p110β isoforms of PI 3K signaling: are they two sides of the same coin?
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Stellettin B Sensitizes Glioblastoma to DNA‐Damaging Treatments by Suppressing PI3K‐Mediated Homologous Recombination Repair
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Growth hormone deficiency in megalencephaly‐capillary malformation syndrome: An association with activating mutations in PIK3CA
inferred← citeshttps://doi.org/10.1002/ajmg.a.63466openalex-snapshot
Molecular characterization of 13 patients with PIK3CA ‐related overgrowth spectrum using a targeted deep sequencing approach
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Megalencephaly Syndromes and Activating Mutations in the PI3K‐AKT Pathway: MPPH and MCAP
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Molecular Mechanisms of Childhood Overgrowth
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GSK3ß‐dependent dysregulation of neurodevelopment in SPG11‐patient induced pluripotent stem cell model
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The Catalytic Enantioselective Total Synthesis of (+)‐Liphagal
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The Catalytic Enantioselective Total Synthesis of (+)‐Liphagal
inferred← citeshttps://doi.org/10.1002/anie.202410919openalex-snapshot
Metabolic Response to Small Molecule Therapy in Colorectal Cancer Tracked with Raman Spectroscopy and Metabolomics
inferred← citeshttps://doi.org/10.1002/ardp.201500468openalex-snapshot
Quinoxaline‐Based Scaffolds Targeting Tyrosine Kinases and Their Potential Anticancer Activity
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Medicinal Attributes of Thienopyrimidine Based Scaffold Targeting Tyrosine Kinases and Their Potential Anticancer Activities
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Fibroblast growth factor 2 and platelet‐derived growth factor, but not platelet lysate, induce proliferation‐dependent, functional class II major histocompatibility complex antigen in human mesenchymal stem cells
inferred← citeshttps://doi.org/10.1002/bies.201200176openalex-snapshot
Phosphatidylinositol‐3,4,5‐trisphosphate: Tool of choice for class I PI 3‐kinases
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Mitochondrial fission‐fusion as an emerging key regulator of cell proliferation and differentiation
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PROTACs: An Emerging Targeting Technique for Protein Degradation in Drug Discovery
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Size assessment and growth control: how adult size is determined in insects
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LC–MS/MS determination of buparlisib, a phosphoinositide 3 kinase inhibitor in rat plasma: Application to a pharmacokinetic study
inferred← citeshttps://doi.org/10.1002/bmc.5015openalex-snapshot
Validated HPLC‐UV method for simultaneous quantification of phosphatidylinositol 3‐kinase inhibitors, copanlisib, duvelisib and idelalisib, in rat plasma: Application to a pharmacokinetic study in rats
inferred← citeshttps://doi.org/10.1002/cam4.1108openalex-snapshot
Comparative molecular profiling of HPV‐induced squamous cell carcinomas
inferred← citeshttps://doi.org/10.1002/cam4.4781openalex-snapshot
Relationship between tumor mutational burden, gene mutation status, and clinical characteristics in 340 cases of lung adenocarcinoma
inferred← citeshttps://doi.org/10.1002/cam4.6543openalex-snapshot
Activation of PI3K /Akt pathway by G protein‐coupled receptor 37 promotes resistance to cisplatin‐induced apoptosis in non‐small cell lung cancer
inferred← citeshttps://doi.org/10.1002/cam4.71225openalex-snapshot
Exploring the Functional Role of Programmed Death‐Ligand 1 ( PD ‐ L1 ) in the Castration‐Resistant Prostate Cancer Using Transcriptomic Sequencing Analysis
inferred← citeshttps://doi.org/10.1002/cbdv.202300050openalex-snapshot
(2 E )‐1‐(2,4,6‐Trimethoxyphenyl)‐3‐(4‐chlorophenyl)prop‐2‐en‐1‐one, a Chalcone Derivative, Promotes Apoptosis by Suppressing RAS‐ERK and AKT/FOXO3a Pathways in Hepatocellular Carcinoma Cells
inferred← citeshttps://doi.org/10.1002/cbdv.202301064openalex-snapshot
Biological Properties of Cyclitols and Their Derivatives
inferred← citeshttps://doi.org/10.1002/cbf.2932openalex-snapshot
Augmentation of ADAMTS9 gene expression by IL‐1β is reversed by NFκB and MAPK inhibitors, but not PI3 kinase inhibitors
inferred← citeshttps://doi.org/10.1002/cbf.3400openalex-snapshot
2‐Hexadecenal inhibits growth of C6 glioma cells
inferred← citeshttps://doi.org/10.1002/cbf.3578openalex-snapshot
Ischaemic preconditioning‐induced serum exosomes protect against myocardial ischaemia/reperfusion injury in rats by activating the PI3K / AKT signalling pathway
inferred← citeshttps://doi.org/10.1002/cbf.3998openalex-snapshot
The PI3K/AKT/mTOR signaling pathway in breast cancer: Review of clinical trials and latest advances
inferred← citeshttps://doi.org/10.1002/cbic.201200089openalex-snapshot
The Chemical Biology of Phosphoinositide 3‐Kinases
inferred← citeshttps://doi.org/10.1002/cbin.11258openalex-snapshot
PTEN promotes intervertebral disc degeneration by regulating nucleus pulposus cell behaviors
inferred← citeshttps://doi.org/10.1002/cmdc.202100731openalex-snapshot
Recent Advances in Dual BRD4‐Kinase Inhibitors Based on Polypharmacology
inferred← citeshttps://doi.org/10.1002/cncr.29480openalex-snapshot
Randomized phase 2 trial of erlotinib in combination with high‐dose celecoxib or placebo in patients with advanced non‐small cell lung cancer
inferred← citeshttps://doi.org/10.1002/cnr2.1889openalex-snapshot
Unraveling the signaling mechanism behind astrocytoma and possible therapeutics strategies: A comprehensive review
inferred← citeshttps://doi.org/10.1002/cnr2.70243openalex-snapshot
Rapid Development of Breast Mass With Recurrent Episodes of Hypoglycemia Should Raise Suspicion of Breast Cancer With Insulinoma: A Case Report
inferred← citeshttps://doi.org/10.1002/cphy.c160015openalex-snapshot
Central Regulation of Glucose Homeostasis
inferred← citeshttps://doi.org/10.1002/cphy.c180010openalex-snapshot
Insulin‐Like Growth Factor I Regulation and Its Actions in Skeletal Muscle
inferred← citeshttps://doi.org/10.1002/cphy.c220015openalex-snapshot
Insulin Regulation of Hepatic Lipid Homeostasis
inferred← citeshttps://doi.org/10.1002/cpt.2254openalex-snapshot
Oncofertility Information Available for Recently Approved Novel Non Cytotoxic and Immunotherapy Oncology Drugs
inferred← citeshttps://doi.org/10.1002/dvdy.22078openalex-snapshot
Organ‐specific lymphangiectasia, arrested lymphatic sprouting, and maturation defects resulting from gene‐targeting of the PI3K regulatory isoforms p85α, p55α, and p50α
inferred← citeshttps://doi.org/10.1002/eji.201040945openalex-snapshot
A class IA PI3K controls inflammatory cytokine production in human neutrophils
inferred← citeshttps://doi.org/10.1002/emmm.201201953openalex-snapshot
Long‐term p110α PI3K inactivation exerts a beneficial effect on metabolism
inferred← citeshttps://doi.org/10.1002/glia.22584openalex-snapshot
The PTEN inhibitor bisperoxovanadium enhances myelination by amplifying IGF‐1 signaling in rat and human oligodendrocyte progenitors
inferred← citeshttps://doi.org/10.1002/hed.24085openalex-snapshot
Past and future impact of next‐generation sequencing in head and neck cancer
inferred← citeshttps://doi.org/10.1002/hed.24910openalex-snapshot
Upregulation of pAKT(Ser473) expression in progression of HPV‐positive oropharyngeal squamous cell carcinoma
inferred← citeshttps://doi.org/10.1002/hed.27718openalex-snapshot
Differential modulation of PI3K /Akt/ mTOR activity by EGFR inhibitors: A rationale for co‐targeting EGFR and PI3K in cisplatin‐resistant HNSCC
inferred← citeshttps://doi.org/10.1002/hep.29715openalex-snapshot
Significance and mechanism of androgen receptor overexpression and androgen receptor/mechanistic target of rapamycin cross‐talk in hepatocellular carcinoma
inferred← citeshttps://doi.org/10.1002/hep.32120openalex-snapshot
Phosphorylation of androgen receptor by mTORC1 promotes liver steatosis and tumorigenesis
inferred← citeshttps://doi.org/10.1002/ijc.24374openalex-snapshot
The Akt inhibitor triciribine sensitizes prostate carcinoma cells to TRAIL‐induced apoptosis
inferred← citeshttps://doi.org/10.1002/ijc.26319openalex-snapshot
PI3K class IB controls the cell cycle checkpoint promoting cell proliferation in hepatocellular carcinoma
inferred← citeshttps://doi.org/10.1002/ijc.28034openalex-snapshot
The novel phosphoinositide 3‐kinase–mammalian target of rapamycin inhibitor, BEZ235, circumvents erlotinib resistance of epidermal growth factor receptor mutant lung cancer cells triggered by hepatocyte growth factor
inferred← citeshttps://doi.org/10.1002/ijc.28112openalex-snapshot
Head and neck cancer: from anatomy to biology
inferred← citeshttps://doi.org/10.1002/ijc.30457openalex-snapshot
BAY 1125976, a selective allosteric AKT1/2 inhibitor, exhibits high efficacy on AKT signaling‐dependent tumor growth in mouse models
inferred← citeshttps://doi.org/10.1002/ijc.70235openalex-snapshot
99m Tc ‐ HP ‐Ark2 SPECT / CT imaging reveals dynamic HER2 regulation in trastuzumab resistance and its reversal by PI3K inhibition
inferred← citeshttps://doi.org/10.1002/iub.1268openalex-snapshot
ST6GalNAcII mediates the invasive properties of breast carcinoma through PI3K/Akt/NF‐κB signaling pathway
inferred← citeshttps://doi.org/10.1002/iub.1412openalex-snapshot
Micro RNA ‐200 promotes lung cancer cell growth through FOG2 ‐independent AKT activation
inferred← citeshttps://doi.org/10.1002/j.2040-4603.2017.tb00749.xopenalex-snapshot
Central Regulation of Glucose Homeostasis
inferred← citeshttps://doi.org/10.1002/j.2040-4603.2019.tb00062.xopenalex-snapshot
Insulin‐Like Growth Factor I Regulation and Its Actions in Skeletal Muscle
inferred← citeshttps://doi.org/10.1002/j.2040-4603.2023.tb00269.xopenalex-snapshot
Insulin Regulation of Hepatic Lipid Homeostasis
inferred← citeshttps://doi.org/10.1002/jbmr.1703openalex-snapshot
Class IA phosphatidylinositol 3-kinase regulates osteoclastic bone resorption through protein kinase B–mediated vesicle transport
inferred← citeshttps://doi.org/10.1002/jbt.22723openalex-snapshot
Sesquiterpenoid bilobalide inhibits gastric carcinoma cell growth and induces apoptosis both in vitro and in vivo models
inferred← citeshttps://doi.org/10.1002/jbt.23313openalex-snapshot
Dieckol, a natural polyphenolic drug, inhibits the proliferation and migration of colon cancer cells by inhibiting PI3K, AKT, and mTOR phosphorylation
inferred← citeshttps://doi.org/10.1002/jbt.23843openalex-snapshot
Asiaticoside protected brain injury in hypertensive intracerebral hemorrhage via activation of the PI3K/AKT pathway
inferred← citeshttps://doi.org/10.1002/jcb.21937openalex-snapshot
Chromosome instability and tumor lethality suppression in carcinogenesis
inferred← citeshttps://doi.org/10.1002/jcb.22272openalex-snapshot
AMP‐activated protein kinase enhances the expression of muscle‐specific ubiquitin ligases despite its activation of IGF‐1/Akt signaling in C2C12 myotubes
inferred← citeshttps://doi.org/10.1002/jcb.22483openalex-snapshot
Nuclear inositide signaling in myelodysplastic syndromes
inferred← citeshttps://doi.org/10.1002/jcb.23285openalex-snapshot
Suppression of the PI3K subunit p85α delays embryoid body development and inhibits cell adhesion
inferred← citeshttps://doi.org/10.1002/jcb.25053openalex-snapshot
Fascaplysin Induces Caspase Mediated Crosstalk Between Apoptosis and Autophagy Through the Inhibition of PI3K/AKT/mTOR Signaling Cascade in Human Leukemia HL‐60 Cells
inferred← citeshttps://doi.org/10.1002/jcb.25159openalex-snapshot
Oncogenic and Therapeutic Targeting of PTEN Loss in Bone Malignancies
inferred← citeshttps://doi.org/10.1002/jcb.25598openalex-snapshot
Dynamics of GFP‐Fusion p110α and p110β Isoforms of PI3K Signaling Pathway in Normal and Cancer Cells
inferred← citeshttps://doi.org/10.1002/jcb.26117openalex-snapshot
An Anti‐Cancer Drug Candidate OSI‐027 and its Analog as Inhibitors of mTOR: Computational Insights Into the Inhibitory Mechanisms
inferred← citeshttps://doi.org/10.1002/jcb.26687openalex-snapshot
The prognostic value of PI3K mutational status in breast cancer: A meta‐analysis
inferred← citeshttps://doi.org/10.1002/jcb.27100openalex-snapshot
Virtual screening of naphthoquinone analogs for potent inhibitors against the cancer‐signaling PI3K/AKT/mTOR pathway
inferred← citeshttps://doi.org/10.1002/jcp.21697openalex-snapshot
Low‐power laser irradiation promotes cell proliferation by activating PI3K/Akt pathway
inferred← citeshttps://doi.org/10.1002/jcp.22482openalex-snapshot
Regulation of PIP5K activity by Arf6 and its physiological significance
inferred← citeshttps://doi.org/10.1002/jcp.23038openalex-snapshot
PI3K: A potential therapeutic target for cancer
inferred← citeshttps://doi.org/10.1002/jcp.24107openalex-snapshot
Dissecting Pin1 and phospho‐pRb regulation
inferred← citeshttps://doi.org/10.1002/jcp.25762openalex-snapshot
Mactosylceramide prevents glial cell overgrowth by inhibiting insulin and fibroblast growth factor receptor signaling
inferred← citeshttps://doi.org/10.1002/jcp.26135openalex-snapshot
Phosphatidylinositol 3‐kinase inhibition potentiates glucocorticoid response in B‐cell acute lymphoblastic leukemia
inferred← citeshttps://doi.org/10.1002/jcp.26539openalex-snapshot
Targeting the phosphatidylinositol 3‐kinase/Akt/mechanistic target of rapamycin signaling pathway in B‐lineage acute lymphoblastic leukemia: An update
inferred← citeshttps://doi.org/10.1002/jcp.27673openalex-snapshot
Targeting phosphoinositide‐3‐kinase pathway in biliary tract cancers: A remedial route?
inferred← citeshttps://doi.org/10.1002/jcp.27863openalex-snapshot
Inhibition of MUC1‐C regulates metabolism by AKT pathway in esophageal squamous cell carcinoma
inferred← citeshttps://doi.org/10.1002/jcp.28727openalex-snapshot
GRP94 promotes muscle differentiation by inhibiting the PI3K/AKT/mTOR signaling pathway
inferred← citeshttps://doi.org/10.1002/jcp.28865openalex-snapshot
Melatonin: A new inhibitor agent for cervical cancer treatment
inferred← citeshttps://doi.org/10.1002/jcp.29811openalex-snapshot
Cre/loxP approach‐mediated downregulation of Pik3c3 inhibits the hypertrophic growth of renal proximal tubule cells
inferred← citeshttps://doi.org/10.1002/jcp.30287openalex-snapshot
Comparative hematopoiesis and signal transduction in model organisms
inferred← citeshttps://doi.org/10.1002/jcp.30573openalex-snapshot
Molecular mechanisms involved in DNA repair in human cancers: An overview of PI3k/Akt signaling and PIKKs crosstalk
inferred← citeshttps://doi.org/10.1002/jcp.30812openalex-snapshot
Vitamin B6 rescues insulin resistance and glucose‐induced DNA damage caused by reduced activity of Drosophila PI3K
inferred← citeshttps://doi.org/10.1002/jcph.6111openalex-snapshot
Predict the Drug–Drug Interaction of a Novel PI3Kα/δ Inhibitor, TQ‐B3525, and Its Two Metabolites Using Physiologically Based Pharmacokinetic Modeling
inferred← citeshttps://doi.org/10.1002/jez.70038openalex-snapshot
Subcutaneous Implantation of Exogenous Melatonin Induces a Polarization Effect on the Weight of Scent Glands in Muskrat
inferred← citeshttps://doi.org/10.1002/jlb.1a0821-413rropenalex-snapshot
The phosphoinositide-3-kinase (PI3K)-delta inhibitor seletalisib impairs monocyte-derived dendritic cells maturation, APC function, and promotes their migration to CCR7 and CXCR4 ligands
inferred← citeshttps://doi.org/10.1002/jnr.25239openalex-snapshot
Apoptosis in the neuroprotective effect of α7 nicotinic receptor in neurodegenerative models
inferred← citeshttps://doi.org/10.1002/jsfa.6251openalex-snapshot
Bioactive‐rich extracts of persimmon, but not nettle, Sideritis , dill or kale, increase eNOS activation and NO bioavailability and decrease endothelin‐1 secretion by human vascular endothelial cells
inferred← citeshttps://doi.org/10.1002/jso.21816openalex-snapshot
Cutaneous melanoma: A model to study cancer metastasis
inferred← citeshttps://doi.org/10.1002/kjm2.12188openalex-snapshot
Ghrelin promotes neural differentiation of adipose tissue‐derived mesenchymal stem cell via AKT/mTOR and β‐catenin signaling pathways
inferred← citeshttps://doi.org/10.1002/mc.20569openalex-snapshot
PI3K signaling maintains c‐myc expression to regulate transcription of E2F1 in pancreatic cancer cells
inferred← citeshttps://doi.org/10.1002/mc.20632openalex-snapshot
Proteasomal non‐catalytic subunit PSMD2 as a potential therapeutic target in association with various clinicopathologic features in lung adenocarcinomas
inferred← citeshttps://doi.org/10.1002/mc.20665openalex-snapshot
Growth factor signaling pathways as targets for prevention of epithelial carcinogenesis
inferred← citeshttps://doi.org/10.1002/mc.23375openalex-snapshot
RETRACTED: LINC02381 aggravates breast cancer through the miR‐1271‐5p/FN1 axis to activate PI3K/AKT pathway
inferred← citeshttps://doi.org/10.1002/mco2.70783openalex-snapshot
From 2D to 3D Bioprinted In Vitro Breast Cancer Model: A Comparative Study of Proliferation, Tissue Structure, and mTOR Signaling
inferred← citeshttps://doi.org/10.1002/med.20207openalex-snapshot
Protein kinases CK1 and CK2 as new targets for neurodegenerative diseases
inferred← citeshttps://doi.org/10.1002/med.21529openalex-snapshot
Therapeutic potential of pteridine derivatives: A comprehensive review
inferred← citeshttps://doi.org/10.1002/med.21634openalex-snapshot
Morpholine as a privileged structure: A review on the medicinal chemistry and pharmacological activity of morpholine containing bioactive molecules
inferred← citeshttps://doi.org/10.1002/med.21676openalex-snapshot
Advances in drug development for targeted therapies for glioblastoma
inferred← citeshttps://doi.org/10.1002/mrd.21083openalex-snapshot
Local effects of the sphingosine 1‐phosphate on prostaglandin F2alpha‐induced luteolysis in the pregnant rat
inferred← citeshttps://doi.org/10.1002/nbm.1764openalex-snapshot
Metabolic consequences of treatment with AKT inhibitor perifosine in breast cancer cells
inferred← citeshttps://doi.org/10.1002/path.2788openalex-snapshot
Genetically informed lung cancer medicine
inferred← citeshttps://doi.org/10.1002/pbc.24301openalex-snapshot
Initial testing (stage 1) of the phosphatidylinositol 3′ kinase inhibitor, SAR245408 (XL147) by the pediatric preclinical testing program
inferred← citeshttps://doi.org/10.1002/pmic.202200077openalex-snapshot
Proteomic alterations in extracellular vesicles induced by oncogenic PIK3CA mutations
inferred← citeshttps://doi.org/10.1002/pros.23834openalex-snapshot
Triptonide acts as a novel antiprostate cancer agent mainly through inhibition of mTOR signaling pathway
inferred← citeshttps://doi.org/10.1002/prot.22265openalex-snapshot
PIK3CA somatic mutations in breast cancer: Mechanistic insights from Langevin dynamics simulations
inferred← citeshttps://doi.org/10.1002/ptr.6798openalex-snapshot
Poncirin downregulates ATP ‐binding cassette transporters to enhance cisplatin sensitivity in cisplatin‐resistant osteosarcoma cells
inferred← citeshttps://doi.org/10.1002/ptr.7867openalex-snapshot
Agrimoniin is a dual inhibitor of AKT and ERK pathways that inhibit pancreatic cancer cell proliferation
inferred← citeshttps://doi.org/10.1002/ptr.7943openalex-snapshot
Targeting HSP90 with picropodophyllin suppresses gastric cancer tumorigenesis by disrupting the association of HSP90 and AKT
inferred← citeshttps://doi.org/10.1002/ptr.8040openalex-snapshot
The pharmacological effects of Berberine and its therapeutic potential in different diseases: Role of the phosphatidylinositol 3‐kinase/ AKT signaling pathway
inferred← citeshttps://doi.org/10.1002/rmv.1843openalex-snapshot
Biology and oncogenicity of the Kaposi sarcoma herpesvirus K1 protein
inferred← citeshttps://doi.org/10.1002/sita.200700143openalex-snapshot
Early biochemical events in leukocyte activation through receptors for IgG
inferred← citeshttps://doi.org/10.1002/slct.201904239openalex-snapshot
Wortmannolol Induces Breast Cancer Cell Death In Vitro and In Vivo by Targeting Phosphoinositide 3‐Kinaseα
inferred← citeshttps://doi.org/10.1002/slct.202301053openalex-snapshot
Epidermal Growth Factor Receptor Inhibiting 4‐Aminoquinazolines as Promising Anticancer Agents: A Patent Review (2000‐Present)
inferred← citeshttps://doi.org/10.1002/smll.201303635openalex-snapshot
Long‐Term Effects of Nanoparticles on Nutrition and Metabolism
inferred← citeshttps://doi.org/10.1002/smll.202207576openalex-snapshot
Multi‐Targeted and On‐Demand Non‐Coding RNA Regulation Nanoplatform against Metastasis and Recurrence of Triple‐Negative Breast Cancer
inferred← citeshttps://doi.org/10.1002/stem.1669openalex-snapshot
Akt Signaling Leads to Stem Cell Activation and Promotes Tumor Development in Epidermis
inferred← citeshttps://doi.org/10.1002/stem.748openalex-snapshot
Phosphatase and Tensin Homolog Regulates the Pluripotent State and Lineage Fate Choice in Human Embryonic Stem Cells
inferred← citeshttps://doi.org/10.1002/tox.23396openalex-snapshot
Estrogen receptor‐α36 is involved in diallyl sulfide‐induced inhibition of malignant growth of HepG2 and Huh7 hepatocellular carcinoma cells
inferred← citeshttps://doi.org/10.1007/1-59745-107-x_8openalex-snapshot
Implications of Thyroid Hormone Signaling Through the Phosphoinositide-3 Kinase for Xenobiotic Disruption of Human Health
inferred← citeshttps://doi.org/10.1007/164_2017_4openalex-snapshot
Major Physiological Signaling Pathways in the Regulation of Cell Proliferation and Survival
inferred← citeshttps://doi.org/10.1007/7355_2016_27openalex-snapshot
Isoform Selective PI3K Inhibitors for Treating Cancer
inferred← citeshttps://doi.org/10.1007/82_2010_52openalex-snapshot
The Regulation of Class IA PI 3-Kinases by Inter-Subunit Interactions
inferred← citeshttps://doi.org/10.1007/82_2010_54openalex-snapshot
Clinical Development of Phosphatidylinositol-3 Kinase Pathway Inhibitors
inferred← citeshttps://doi.org/10.1007/82_2010_62openalex-snapshot
Faithfull Modeling of PTEN Loss Driven Diseases in the Mouse
inferred← citeshttps://doi.org/10.1007/82_2010_63openalex-snapshot
Comparing the Roles of the p110α and p110β Isoforms of PI3K in Signaling and Cancer
inferred← citeshttps://doi.org/10.1007/82_2010_66openalex-snapshot
AKT Signaling in Physiology and Disease
inferred← citeshttps://doi.org/10.1007/82_2010_80openalex-snapshot
Phosphatidylinositol 3-Kinase: The Oncoprotein
inferred← citeshttps://doi.org/10.1007/82_2010_82openalex-snapshot
The Neurodevelopmental Implications of PI3K Signaling
inferred← citeshttps://doi.org/10.1007/82_2014_400openalex-snapshot
The NS1 Protein: A Multitasking Virulence Factor
inferred← citeshttps://doi.org/10.1007/978-0-387-71518-6_18openalex-snapshot
VEGF Signal Tranduction in Angiogenesis
inferred← citeshttps://doi.org/10.1007/978-0-387-71518-6_9openalex-snapshot
Platelet-Derived Growth Factor
inferred← citeshttps://doi.org/10.1007/978-0-85729-482-1_33openalex-snapshot
Molecular Biology of Urothelial Cancer
inferred← citeshttps://doi.org/10.1007/978-1-4020-8341-9_3openalex-snapshot
Targeting Signaling Pathways – In the Search of Melanoma’s Achilles’ Heel
inferred← citeshttps://doi.org/10.1007/978-1-4419-0461-4_93openalex-snapshot
Phosphoinositide 3-Kinase
inferred← citeshttps://doi.org/10.1007/978-1-4419-0507-9_2openalex-snapshot
Signal Transduction Pathways as Therapeutic Targets in Cancer Therapy
inferred← citeshttps://doi.org/10.1007/978-1-4419-0787-5_14openalex-snapshot
Molecular Pathology of Lung Cancer
inferred← citeshttps://doi.org/10.1007/978-1-4419-1432-3_2openalex-snapshot
A Role for eNOS in Oncogenic Ras-Driven Cancer
inferred← citeshttps://doi.org/10.1007/978-1-4419-1513-9_9openalex-snapshot
Targeting the PI3K/Akt/mTOR Pathway in AIDS-Associated Malignancies
inferred← citeshttps://doi.org/10.1007/978-1-4419-5797-9_21openalex-snapshot
Crosstalk Between Mitogen-Activated Protein Kinase and Phosphoinositide-3 Kinase Signaling Pathways in Development and Disease
inferred← citeshttps://doi.org/10.1007/978-1-4419-7203-3_18openalex-snapshot
Effects and Therapeutic Potential of Targeting Dysregulated Signaling Axes in Squamous Cell Carcinoma: Another Kinase of Transcription and Mammalian Target of Rapamycin
inferred← citeshttps://doi.org/10.1007/978-1-4419-9755-5_7openalex-snapshot
Prognostic Markers in Colon Cancer
inferred← citeshttps://doi.org/10.1007/978-1-4419-9911-5_2openalex-snapshot
Insulin/IGF-1 Signaling Nodes and their Role in Carcinogenesis
inferred← citeshttps://doi.org/10.1007/978-1-4471-4258-4_31openalex-snapshot
Management of Advanced Endometrial Cancer and Inhibitors of the PI3K/AKT/mTOR Pathway
inferred← citeshttps://doi.org/10.1007/978-1-4614-0598-6_12openalex-snapshot
Calories and Cancer: The Role of Insulin-Like Growth Factor-1
inferred← citeshttps://doi.org/10.1007/978-1-4614-3209-8_101openalex-snapshot
Targeting the PI3K/Akt/mTOR Pathway in Ocular Neovascularization
inferred← citeshttps://doi.org/10.1007/978-1-4614-5647-6_4openalex-snapshot
Major Signaling Pathways Involved in Breast Cancer
inferred← citeshttps://doi.org/10.1007/978-1-4614-8412-7_6openalex-snapshot
The PI3K Pathway in Colorectal Cancers
inferred← citeshttps://doi.org/10.1007/978-1-4939-1393-0_17openalex-snapshot
The PI3K-AKT-mTOR Signaling Network in AML
inferred← citeshttps://doi.org/10.1007/978-1-4939-1798-3_12openalex-snapshot
Novel Targets for Future Medical Treatments
inferred← citeshttps://doi.org/10.1007/978-1-4939-3299-3_2openalex-snapshot
PTEN at 18: Still Growing
inferred← citeshttps://doi.org/10.1007/978-1-4939-3554-3_11openalex-snapshot
Targeted Therapy in Melanoma
inferred← citeshttps://doi.org/10.1007/978-1-4939-3746-2_6openalex-snapshot
Assays to Measure PTEN Lipid Phosphatase Activity In Vitro from Purified Enzyme or Immunoprecipitates
inferred← citeshttps://doi.org/10.1007/978-1-4939-7234-0_23openalex-snapshot
Targeting the PI3K/AKT/mTOR Pathway in Bladder Cancer
inferred← citeshttps://doi.org/10.1007/978-1-59745-474-2_7openalex-snapshot
Targeting Survival Cascades Induced by Activation of Ras/Raf/MEK/ERK and PI3K/Akt Pathways to Sensitize Cancer Cells to Therapy
inferred← citeshttps://doi.org/10.1007/978-1-60327-271-1_5openalex-snapshot
mTOR Signaling in Glioblastoma: Lessons Learned from Bench to Bedside
inferred← citeshttps://doi.org/10.1007/978-1-60327-271-1_6openalex-snapshot
mTOR and Cancer Therapy: General Principles
inferred← citeshttps://doi.org/10.1007/978-1-60327-424-1_9openalex-snapshot
Targeted Therapy in Melanoma
inferred← citeshttps://doi.org/10.1007/978-1-60327-542-2_7openalex-snapshot
Factors in the Causation of Female Cancers and Prevention
inferred← citeshttps://doi.org/10.1007/978-1-60327-553-8_15openalex-snapshot
The PTEN/PI3 Kinase Pathway in Human Glioma
inferred← citeshttps://doi.org/10.1007/978-1-60327-553-8_5openalex-snapshot
Pten-Deficient Mouse Models for High-Grade Astrocytomas
inferred← citeshttps://doi.org/10.1007/978-1-60761-244-5_10openalex-snapshot
Fluorescence Polarization and Time-Resolved Fluorescence Resonance Energy Transfer Techniques for PI3K Assays
inferred← citeshttps://doi.org/10.1007/978-1-60761-780-8_1openalex-snapshot
Approaches and Applications of Quantitative LC-MS for Proteomics and Activitomics
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