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Mechanistic approaches to the study of evolution: the functional synthesis
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Outgoing claims: the papers this work cites, builds on, or argues with.
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Resynthesizing Evolutionary and Developmental Biology
inferredcites →https://doi.org/10.1006/jmbi.1996.0040openalex-snapshot
The Crystal Structure of a High Oxygen Affinity Species of Haemoglobin (Bar-headed Goose Haemoglobin in the Oxy Form)
inferredcites →https://doi.org/10.1006/pest.1996.0038openalex-snapshot
Comparison of an Esterase Associated with Organophosphate Resistance inLucilia cuprinawith an Orthologue Not Associated with Resistance inDrosophila melanogaster
inferredcites →https://doi.org/10.1007/978-3-642-86659-3openalex-snapshot
Evolution by Gene Duplication
inferredcites →https://doi.org/10.1016/0020-711x(94)90119-8openalex-snapshot
The origins of order; self organization and selection in evolution
inferredcites →https://doi.org/10.1016/0040-5809(83)90014-xopenalex-snapshot
A simple stochastic gene substitution model
inferredcites →https://doi.org/10.1016/j.cbpa.2006.08.011openalex-snapshot
Enzyme promiscuity: evolutionary and mechanistic aspects
inferredcites →https://doi.org/10.1016/j.cub.2005.12.028openalex-snapshot
Experimental Evolution of Mating Discrimination in Budding Yeast
inferredcites →https://doi.org/10.1016/j.gene.2005.09.028openalex-snapshot
Tertiary structure and spectral tuning of UV and violet pigments in vertebrates
inferredcites →https://doi.org/10.1016/j.tig.2006.08.010openalex-snapshot
Adaptive evolution of tetrodotoxin resistance in animals
inferredcites →https://doi.org/10.1016/j.tig.2007.05.001openalex-snapshot
Evo-devo and the evolution of social behavior
inferredcites →https://doi.org/10.1016/j.tins.2005.09.006openalex-snapshot
The neurogenetics and evolution of food-related behaviour
inferredcites →https://doi.org/10.1016/s0169-5347(97)01098-7openalex-snapshot
Evolution and speciation on holey adaptive landscapes
inferredcites →https://doi.org/10.1016/s0378-1119(00)00474-1openalex-snapshot
Adaptive evolution of the African and Indonesian coelacanths to deep-sea environments
inferredcites →https://doi.org/10.1016/s0378-1119(02)00845-4openalex-snapshot
Molecular evolution of color vision in vertebrates
inferredcites →https://doi.org/10.1016/s0965-1748(96)00065-3openalex-snapshot
cDNA cloning, baculovirus-expression and kinetic properties of the esterase, E3, involved in organophosphorus resistance in Lucilia cuprina
inferredcites →https://doi.org/10.1016/s0965-1748(99)00035-1openalex-snapshot
The same amino acid substitution in orthologous esterases confers organophosphate resistance on the house fly and a blowfly
inferredcites →https://doi.org/10.1016/s0969-2126(94)00104-9openalex-snapshot
Structure of 3–isopropylmalate dehydrogenase in complex with NAD+: ligand–induced loop closing and mechanism for cofactor specificity
inferredcites →https://doi.org/10.1016/s1074-5521(99)80033-7openalex-snapshot
Catalytic promiscuity and the evolution of new enzymatic activities
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Enzymes with extra talents: moonlighting functions and catalytic promiscuity
inferredcites →https://doi.org/10.1017/cbo9780511542619openalex-snapshot
The Evolution of Population Biology
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Catalytic mechanism of NADP+-dependent isocitrate dehydrogenase: implications from the structures of magnesium-isocitrate and NADP+ complexes
inferredcites →https://doi.org/10.1038/225563a0openalex-snapshot
Natural Selection and the Concept of a Protein Space
inferredcites →https://doi.org/10.1038/304412a0openalex-snapshot
Nucleotide polymorphism at the alcohol dehydrogenase locus of Drosophila melanogaster
inferredcites →https://doi.org/10.1038/332640a0openalex-snapshot
Female choice selects for male sexual tail ornaments in the monogamous swallow
inferredcites →https://doi.org/10.1038/351652a0openalex-snapshot
Adaptive protein evolution at the Adh locus in Drosophila
inferredcites →https://doi.org/10.1038/374057a0openalex-snapshot
Reconstructing the evolutionary history of the artiodactyl ribonuclease superfamily
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The evolution of apical dominance in maize
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Regulatory evolution of shavenbaby/ovo underlies multiple cases of morphological parallelism
inferredcites →https://doi.org/10.1038/nature01906openalex-snapshot
Evolution of cooperation and conflict in experimental bacterial populations
inferredcites →https://doi.org/10.1038/nature01977openalex-snapshot
Inferring the palaeoenvironment of ancient bacteria on the basis of resurrected proteins
inferredcites →https://doi.org/10.1038/nature02415openalex-snapshot
Genetic and developmental basis of evolutionary pelvic reduction in threespine sticklebacks
inferredcites →https://doi.org/10.1038/nature03235openalex-snapshot
Chance caught on the wing: cis-regulatory evolution and the origin of pigment patterns in Drosophila
inferredcites →https://doi.org/10.1038/nature03444openalex-snapshot
Evolutionary diversification of TTX-resistant sodium channels in a predator–prey interaction
inferredcites →https://doi.org/10.1038/nature03863openalex-snapshot
The origin of the naked grains of maize
inferredcites →https://doi.org/10.1038/nature04597openalex-snapshot
Repeated morphological evolution through cis-regulatory changes in a pleiotropic gene
inferredcites →https://doi.org/10.1038/nature05764openalex-snapshot
Maintaining a behaviour polymorphism by frequency-dependent selection on a single gene
inferredcites →https://doi.org/10.1038/ng1553openalex-snapshot
Resurrecting ancestral alcohol dehydrogenases from yeast
inferredcites →https://doi.org/10.1038/ng1554openalex-snapshot
The transcriptional consequences of mutation and natural selection in Caenorhabditis elegans
inferredcites →https://doi.org/10.1038/ng1700openalex-snapshot
Genetic analysis of cavefish reveals molecular convergence in the evolution of albinism
inferredcites →https://doi.org/10.1038/ng1812openalex-snapshot
Parallel adaptive origins of digestive RNases in Asian and African leaf monkeys
inferredcites →https://doi.org/10.1038/nrg1088openalex-snapshot
Evolution experiments with microorganisms: the dynamics and genetic bases of adaptation
inferredcites →https://doi.org/10.1038/nrg1324openalex-snapshot
Resurrecting ancient genes: experimental analysis of extinct molecules
inferredcites →https://doi.org/10.1046/j.1365-2540.2001.00895.xopenalex-snapshot
Statistical tests of selective neutrality in the age of genomics
inferredcites →https://doi.org/10.1063/1.3050879openalex-snapshot
The Structure of Scientific Revolutions
inferredcites →https://doi.org/10.1073/pnas.0308479101openalex-snapshot
Parallel genetic basis for repeated evolution of armor loss in Alaskan threespine stickleback populations
inferredcites →https://doi.org/10.1073/pnas.0404397101openalex-snapshot
Evolutionary genomics of ecological specialization
inferredcites →https://doi.org/10.1073/pnas.0431157100openalex-snapshot
The genetic basis of adaptive melanism in pocket mice
inferredcites →https://doi.org/10.1073/pnas.0504033102openalex-snapshot
Directed evolution of d -sialic acid aldolase to l -3-deoxy- manno -2-octulosonic acid ( l -KDO) aldolase
inferredcites →https://doi.org/10.1073/pnas.0509590103openalex-snapshot
Amplification of DNA from preserved specimens shows blowflies were preadapted for the rapid evolution of insecticide resistance
inferredcites →https://doi.org/10.1073/pnas.0510740103openalex-snapshot
Comprehensive mutation identification in an evolved bacterial cooperator and its cheating ancestor
inferredcites →https://doi.org/10.1073/pnas.0601738103openalex-snapshot
Positive selection driving diversification in plant secondary metabolism
inferredcites →https://doi.org/10.1073/pnas.0602917103openalex-snapshot
Tests of parallel molecular evolution in a long-term experiment with Escherichia coli
inferredcites →https://doi.org/10.1073/pnas.072626199openalex-snapshot
Complementary advantageous substitutions in the evolution of an antiviral RNase of higher primates
inferredcites →https://doi.org/10.1073/pnas.091553298openalex-snapshot
Evolution of vertebrate steroid receptors from an ancestral estrogen receptor by ligand exploitation and serial genome expansions
inferredcites →https://doi.org/10.1073/pnas.1532535100openalex-snapshot
Molecular analysis of the evolutionary significance of ultraviolet vision in vertebrates
inferredcites →https://doi.org/10.1073/pnas.201257398openalex-snapshot
Molecular genetics and the evolution of ultraviolet vision in vertebrates
inferredcites →https://doi.org/10.1073/pnas.88.15.6519openalex-snapshot
Adaptation of bird hemoglobins to high altitudes: demonstration of molecular mechanism by protein engineering.
inferredcites →https://doi.org/10.1073/pnas.92.25.11666openalex-snapshot
A highly active decarboxylating dehydrogenase with rationally inverted coenzyme specificity.
inferredcites →https://doi.org/10.1073/pnas.94.14.7464openalex-snapshot
A single amino acid substitution converts a carboxylesterase to an organophosphorus hydrolase and confers insecticide resistance on a blowfly
inferredcites →https://doi.org/10.1073/pnas.94.7.3104openalex-snapshot
Protein engineering reveals ancient adaptive replacements in isocitrate dehydrogenase
inferredcites →https://doi.org/10.1073/pnas.96.11.6279openalex-snapshot
Adaptive evolution of color vision of the Comoran coelacanth ( Latimeria chalumnae )
inferredcites →https://doi.org/10.1073/pnas.96.22.12305openalex-snapshot
A structural view of evolutionary divergence
inferredcites →https://doi.org/10.1074/jbc.274.4.2344openalex-snapshot
Redesigning the Substrate Specificity of an Enzyme by Cumulative Effects of the Mutations of Non-active Site Residues
inferredcites →https://doi.org/10.1086/303217openalex-snapshot
A Dynamical Theory of Speciation on Holey Adaptive Landscapes
inferredcites →https://doi.org/10.1093/genetics/123.3.585openalex-snapshot
Statistical method for testing the neutral mutation hypothesis by DNA polymorphism.
inferredcites →https://doi.org/10.1093/genetics/151.4.1531openalex-snapshot
Preservation of Duplicate Genes by Complementary, Degenerative Mutations
inferredcites →https://doi.org/10.1093/genetics/153.2.919openalex-snapshot
The Molecular Genetics of Red and Green Color Vision in Mammals
inferredcites →https://doi.org/10.1093/genetics/158.4.1697openalex-snapshot
The Molecular Genetics and Evolution of Red and Green Color Vision in Vertebrates
inferredcites →https://doi.org/10.1093/genetics/162.4.2017openalex-snapshot
Changing Effective Population Size and the McDonald-Kreitman Test
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A MOLECULAR APPROACH TO THE STUDY OF GENIC HETEROZYGOSITY IN NATURAL POPULATIONS. I. THE NUMBER OF ALLELES AT DIFFERENT LOCI IN DROSOPHILA PSEUDOOBSCURA
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Color vision of the coelacanth (Latimeria chalumnae) and adaptive evolution of rhodopsin (RH1) and rhodopsin-like (RH2) pigments
inferredcites →https://doi.org/10.1093/molbev/msj062openalex-snapshot
From DNA to Fitness Differences: Sequences and Structures of Adaptive Variants of Colias Phosphoglucose Isomerase (PGI)
inferredcites →https://doi.org/10.1093/oso/9780195079517.001.0001openalex-snapshot
The Origins of Order
inferredcites →https://doi.org/10.1093/oxfordjournals.molbev.a004148openalex-snapshot
Codon-Substitution Models for Detecting Molecular Adaptation at Individual Sites Along Specific Lineages
inferredcites →https://doi.org/10.1093/oxfordjournals.molbev.a004211openalex-snapshot
Recreating a Functional Ancestral Archosaur Visual Pigment
inferredcites →https://doi.org/10.1093/oxfordjournals.molbev.a025932openalex-snapshot
The structural basis of molecular adaptation
inferredcites →https://doi.org/10.1093/oxfordjournals.molbev.a025956openalex-snapshot
The "five-sites" rule and the evolution of red and green color vision in mammals
inferredcites →https://doi.org/10.1093/oxfordjournals.molbev.a040173openalex-snapshot
Molecular adaptation of a leaf-eating bird: stomach lysozyme of the hoatzin.
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The spandrels of San Marco and the Panglossian paradigm: a critique of the adaptationist programme
inferredcites →https://doi.org/10.1110/ps.03117204openalex-snapshot
Directed evolution relieves product inhibition and confers in vivo function to a rationally designed tyrosine aminotransferase
inferredcites →https://doi.org/10.1111/j.0014-3820.2000.tb00544.xopenalex-snapshot
PERSPECTIVE: EVOLUTIONARY DEVELOPMENTAL BIOLOGY AND THE PROBLEM OF VARIATION
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Isolation of a cluster esterase genes associated with organophosphate resistance in Lucilia cuprina
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NATURAL SELECTION ON COLOR PATTERNS IN POECILIA RETICULATA
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MOLECULAR EVOLUTION OVER THE MUTATIONAL LANDSCAPE
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BUTTERFLY WING MARKINGS ARE MORE ADVANTAGEOUS DURING HANDLING THAN DURING THE INITIAL STRIKE OF AN AVIAN PREDATOR
inferredcites →https://doi.org/10.1111/j.1558-5646.1989.tb02569.xopenalex-snapshot
VISUALIZING MULTIVARIATE SELECTION
inferredcites →https://doi.org/10.1111/j.1558-5646.2007.00105.xopenalex-snapshot
THE LOCUS OF EVOLUTION: EVO DEVO AND THE GENETICS OF ADAPTATION
inferredcites →https://doi.org/10.1126/science.1074170openalex-snapshot
A Single P450 Allele Associated with Insecticide Resistance in Drosophila
inferredcites →https://doi.org/10.1126/science.1086185openalex-snapshot
Resurrecting the Ancestral Steroid Receptor: Ancient Origin of Estrogen Signaling
inferredcites →https://doi.org/10.1126/science.1099597openalex-snapshot
Evolution of Coral Pigments Recreated
inferredcites →https://doi.org/10.1126/science.1103776openalex-snapshot
Darwinian Selection on a Selfing Locus
inferredcites →https://doi.org/10.1126/science.1106974openalex-snapshot
The Selective Cause of an Ancient Adaptation
inferredcites →https://doi.org/10.1126/science.1107239openalex-snapshot
Widespread Parallel Evolution in Sticklebacks by Repeated Fixation of Ectodysplasin Alleles
inferredcites →https://doi.org/10.1126/science.1115649openalex-snapshot
The Biochemical Architecture of an Ancient Adaptive Landscape
inferredcites →https://doi.org/10.1126/science.1123348openalex-snapshot
Evolution of Hormone-Receptor Complexity by Molecular Exploitation
inferredcites →https://doi.org/10.1126/science.1123539openalex-snapshot
Darwinian Evolution Can Follow Only Very Few Mutational Paths to Fitter Proteins
inferredcites →https://doi.org/10.1126/science.1126121openalex-snapshot
A Single Amino Acid Mutation Contributes to Adaptive Beach Mouse Color Pattern
inferredcites →https://doi.org/10.1126/science.1126410openalex-snapshot
An SNP Caused Loss of Seed Shattering During Rice Domestication
inferredcites →https://doi.org/10.1126/science.1133479openalex-snapshot
Direct Demonstration of an Adaptive Constraint
inferredcites →https://doi.org/10.1126/science.1133953openalex-snapshot
Two Dobzhansky-Muller Genes Interact to Cause Hybrid Lethality in Drosophila
inferredcites →https://doi.org/10.1126/science.1142819openalex-snapshot
Crystal Structure of an Ancient Protein: Evolution by Conformational Epistasis
inferredcites →https://doi.org/10.1126/science.277.5327.834openalex-snapshot
Natural Behavior Polymorphism Due to a cGMP-Dependent Protein Kinase of Drosophila
inferredcites →https://doi.org/10.1126/science.279.5359.2115openalex-snapshot
Contingency and Determinism in Replicated Adaptive Radiations of Island Lizards
inferredcites →https://doi.org/10.1126/science.3201242openalex-snapshot
A Specific, Highly Active Malate Dehydrogenase by Redesign of a Lactate Dehydrogenase Framework
inferredcites →https://doi.org/10.1128/mmbr.47.2.150-168.1983openalex-snapshot
Selection in chemostats
inferredcites →https://doi.org/10.1146/annurev.biochem.70.1.209openalex-snapshot
Divergent Evolution of Enzymatic Function: Mechanistically Diverse Superfamilies and Functionally Distinct Suprafamilies
inferredcites →https://doi.org/10.1146/annurev.es.26.110195.003125openalex-snapshot
MULTIPLE FITNESS PEAKS AND EPISTASIS
inferredcites →https://doi.org/10.1146/annurev.ge.25.120191.003213openalex-snapshot
GENETIC MECHANISMS FOR ADAPTING TO A CHANGING ENVIRONMENT
inferredcites →https://doi.org/10.1146/annurev.genet.39.073003.112420openalex-snapshot
Molecular Signatures of Natural Selection
inferredcites →https://doi.org/10.1371/journal.pbio.0050219openalex-snapshot
Adaptive Variation in Beach Mice Produced by Two Interacting Pigmentation Genes
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High-Altitude Respiration of Geese. The Primary Structures of the Major and Minor Hemoglobin-Components of Adult Andean Goose (Chloephaga melanoptera, Anatidae): the Mutation Leu → Ser in Position 55 of the ß-Chains
inferredcites →https://doi.org/10.1534/genetics.106.064543openalex-snapshot
Cis-regulatory Evolution of Chalcone-Synthase Expression in the Genus Arabidopsis
inferredcites →https://doi.org/10.1534/genetics.106.066597openalex-snapshot
Cis-Regulatory Elements in the Accord Retrotransposon Result in Tissue-Specific Expression of the Drosophila melanogaster Insecticide Resistance Gene Cyp6g1
inferredcites →https://doi.org/10.1534/genetics.106.069906openalex-snapshot
Adaptive Divergence in Experimental Populations of Pseudomonas fluorescens. III. Mutational Origins of Wrinkly Spreader Diversity
inferredcites →https://doi.org/10.1554/04-272openalex-snapshot
PERSPECTIVE:SIGN EPISTASIS AND GENETIC CONSTRAINT ON EVOLUTIONARY TRAJECTORIES
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The Origins of Theoretical Population Genetics.
inferredcites →https://doi.org/10.5962/bhl.title.105342openalex-snapshot
Mendel's principles of heredity : a defence /
inferredcites →https://doi.org/10.5962/bhl.title.124635openalex-snapshot
Natural theology : or, Evidences of the existence and attributes of the Deity, collected from the appearances of nature /
inferredcites →https://doi.org/10.5962/bhl.title.1348openalex-snapshot
Materials for the study of variation treated with especial regard to discontinuity in the origin of species
inferredcites →https://doi.org/10.5962/bhl.title.17250openalex-snapshot
Materials for the study of variation treated with especial regard to discontinuity in the origin of species
inferredcites →https://doi.org/10.5962/bhl.title.27468openalex-snapshot
The genetical theory of natural selection
inferredcites →https://doi.org/10.5962/bhl.title.51240openalex-snapshot
Natural theology : or, Evidences of the existence and attributes of the Deity, collected from the appearances of nature
inferredcites →https://doi.org/10.5962/bhl.title.88017openalex-snapshot
Materials for the study of variation treated with especial regard to discontinuity in the origin of species
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The Structure of Scientific Revolutions
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The Origins of Theoretical Population Genetics
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
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Valeriana alanyense (Caprifoliaceae): a new species from Southwest Anatolia (Turkey) based on morphological and molecular data
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Evolutionary systems biology: What it is and why it matters
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The biology of seed discrimination and its role in shaping the foraging ecology of carabids: A review
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A Mechanism for Evolving Novel Plant Sesquiterpene Synthase Function
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How mutational epistasis impairs predictability in protein evolution and design
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Comparative analysis of sequence covariation methods to mine evolutionary hubs: Examples from selected GPCR families
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Speciation genetics: Limits and promises
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Coding of Class I and II Aminoacyl-tRNA Synthetases
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Evolutionary Systems Biology: Historical and Philosophical Perspectives on an Emerging Synthesis
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Toll-Like Receptor Function and Evolution in Primates
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Functional Genomic Insights into Regulatory Mechanisms of High-Altitude Adaptation
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High-Throughput Reconstruction of Ancestral Protein Sequence, Structure, and Molecular Function
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Experimental Approaches to Evaluate the Contributions of Candidate Protein-Coding Mutations to Phenotypic Evolution
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Separating Spandrels from Phenotypic Targets of Selection in Adaptive Molecular Evolution
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Molecularizing Evolutionary Biology
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cGMP-Dependent Protein Kinase as a Modifier of Behaviour
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Personality-Associated Genetic Variation in Birds and Its Possible Significance for Avian Evolution, Conservation, and Welfare
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Arms Race Between Plants and Animals: Biotransformation System
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Experimental Evolution of Escherichia coli Harboring an Ancient Translation Protein
inferred← citeshttps://doi.org/10.1007/s00239-024-10162-3openalex-snapshot
Extant Sequence Reconstruction: The Accuracy of Ancestral Sequence Reconstructions Evaluated by Extant Sequence Cross-Validation
inferred← citeshttps://doi.org/10.1007/s00249-018-1281-7openalex-snapshot
Molecular evolution between chemistry and biology
inferred← citeshttps://doi.org/10.1007/s10838-010-9123-zopenalex-snapshot
How Evolutionary Biology Presently Pervades Cell and Molecular Biology
inferred← citeshttps://doi.org/10.1007/s10955-018-1975-3openalex-snapshot
The Influence of Higher-Order Epistasis on Biological Fitness Landscape Topography
inferred← citeshttps://doi.org/10.1007/s11120-008-9324-zopenalex-snapshot
Directing the evolution of Rubisco and Rubisco activase: first impressions of a new tool for photosynthesis research
inferred← citeshttps://doi.org/10.1007/s11427-018-9403-yopenalex-snapshot
Whole genome engineering by synthesis
inferred← citeshttps://doi.org/10.1007/s12038-014-9414-3openalex-snapshot
Biochemistry and evolutionary biology: Two disciplines that need each other
inferred← citeshttps://doi.org/10.1007/s12038-015-9514-8openalex-snapshot
Evolutionary change and phylogenetic relationships in light of horizontal gene transfer
inferred← citeshttps://doi.org/10.1007/s12038-017-9673-xopenalex-snapshot
What history tells us XLII. A ‘new’ view of proteins
inferred← citeshttps://doi.org/10.1007/s12038-020-00129-zopenalex-snapshot
Evolutionary Cell Biology (ECB): Lessons, challenges, and opportunities for the integrative study of cell evolution
inferred← citeshttps://doi.org/10.1007/s13752-015-0202-6openalex-snapshot
A Philosophical Perspective on Evolutionary Systems Biology
inferred← citeshttps://doi.org/10.1007/s42832-026-0460-1openalex-snapshot
Quantifying taxonomy-function associations across hierarchical scales of bacterial nitrogen cycling
inferred← citeshttps://doi.org/10.1016/b978-0-12-374984-0.00010-3openalex-snapshot
Adaptive Landscapes
inferred← citeshttps://doi.org/10.1016/b978-0-12-409547-2.14650-5openalex-snapshot
Vertical Investigations of Enzyme Evolution Using Ancestral Sequence Reconstruction
inferred← citeshttps://doi.org/10.1016/b978-0-12-409547-2.14712-2openalex-snapshot
Enzyme Evolution in Secondary Metabolism
inferred← citeshttps://doi.org/10.1016/b978-0-12-800049-6.00184-0openalex-snapshot
Systems in Evolutionary Systems Biology
inferred← citeshttps://doi.org/10.1016/b978-0-12-809633-8.06008-8openalex-snapshot
Adaptive Landscapes ☆
inferred← citeshttps://doi.org/10.1016/b978-0-443-24031-7.00001-5openalex-snapshot
Introduction to Ecology
inferred← citeshttps://doi.org/10.1016/j.bbadis.2020.165821openalex-snapshot
Interplay between hormones and exercise on hippocampal plasticity across the lifespan
inferred← citeshttps://doi.org/10.1016/j.bbapap.2017.08.006openalex-snapshot
Back to the future: Rational maps for exploring acetylcholine receptor space and time
inferred← citeshttps://doi.org/10.1016/j.bpj.2010.04.076openalex-snapshot
Experimental Evolution of Adenylate Kinase Reveals Contrasting Strategies toward Protein Thermostability
inferred← citeshttps://doi.org/10.1016/j.cbpa.2008.01.027openalex-snapshot
Advances in laboratory evolution of enzymes
inferred← citeshttps://doi.org/10.1016/j.cbpa.2017.10.010openalex-snapshot
Modern methods for laboratory diversification of biomolecules
inferred← citeshttps://doi.org/10.1016/j.cell.2008.05.042openalex-snapshot
Mistranslation-Induced Protein Misfolding as a Dominant Constraint on Coding-Sequence Evolution
inferred← citeshttps://doi.org/10.1016/j.cell.2012.05.033openalex-snapshot
Adaptive Mutations that Prevent Crosstalk Enable the Expansion of Paralogous Signaling Protein Families
inferred← citeshttps://doi.org/10.1016/j.cell.2020.08.012openalex-snapshot
Deep Mutational Scanning of SARS-CoV-2 Receptor Binding Domain Reveals Constraints on Folding and ACE2 Binding
inferred← citeshttps://doi.org/10.1016/j.cell.2024.08.028openalex-snapshot
Modern microbiology: Embracing complexity through integration across scales
inferred← citeshttps://doi.org/10.1016/j.cels.2025.101262openalex-snapshot
Evolutionary paths that link orthogonal pairs of binding proteins
inferred← citeshttps://doi.org/10.1016/j.chembiol.2015.12.010openalex-snapshot
Ancestral Protein Reconstruction Yields Insights into Adaptive Evolution of Binding Specificity in Solute-Binding Proteins
inferred← citeshttps://doi.org/10.1016/j.csbj.2021.03.008openalex-snapshot
Ancestral sequence reconstruction - An underused approach to understand the evolution of gene function in plants?
inferred← citeshttps://doi.org/10.1016/j.cub.2012.07.055openalex-snapshot
Protein Evolution: When Two Become Three
inferred← citeshttps://doi.org/10.1016/j.cub.2015.12.027openalex-snapshot
Posttranslational Regulation: A Way to Evolve
inferred← citeshttps://doi.org/10.1016/j.cub.2018.10.019openalex-snapshot
Pseudogenization and Resurrection of a Speciation Gene
inferred← citeshttps://doi.org/10.1016/j.envres.2021.112040openalex-snapshot
Effects of endocrine disrupting chemicals on gonad development: Mechanistic insights from fish and mammals
inferred← citeshttps://doi.org/10.1016/j.gde.2009.10.003openalex-snapshot
Evolution of transcriptional control in mammals
inferred← citeshttps://doi.org/10.1016/j.gde.2013.10.007openalex-snapshot
Should evolutionary geneticists worry about higher-order epistasis?
inferred← citeshttps://doi.org/10.1016/j.gene.2023.147517openalex-snapshot
The molecular background of the aspartate aminotransferase polymorphism in Littorina snails maintained by strong selection on small spatial scales
inferred← citeshttps://doi.org/10.1016/j.heliyon.2023.e14466openalex-snapshot
The origin of genetic and metabolic systems: Evolutionary structuralinsights
inferred← citeshttps://doi.org/10.1016/j.jgg.2011.06.001openalex-snapshot
Evolutionary rewiring and reprogramming of bacterial transcription regulation
inferred← citeshttps://doi.org/10.1016/j.jmb.2008.01.043openalex-snapshot
A Study in Molecular Contingency: Glutamine Phosphoribosylpyrophosphate Amidotransferase is a Promiscuous and Evolvable Phosphoribosylanthranilate Isomerase
inferred← citeshttps://doi.org/10.1016/j.jmb.2009.07.015openalex-snapshot
Epistasis among Deleterious Mutations in the HIV-1 Protease
inferred← citeshttps://doi.org/10.1016/j.jmb.2010.09.034openalex-snapshot
Evolutionary Origin of a Secondary Structure: π-Helices as Cryptic but Widespread Insertional Variations of α-Helices That Enhance Protein Functionality
inferred← citeshttps://doi.org/10.1016/j.jmb.2014.05.019openalex-snapshot
Systematic Exploration of Ubiquitin Sequence, E1 Activation Efficiency, and Experimental Fitness in Yeast
inferred← citeshttps://doi.org/10.1016/j.mce.2008.06.011openalex-snapshot
The evolution of the ligand/receptor couple: A long road from comparative endocrinology to comparative genomics
inferred← citeshttps://doi.org/10.1016/j.plrev.2016.11.003openalex-snapshot
Models of evolution and evolutionary game theory
inferred← citeshttps://doi.org/10.1016/j.shpsc.2010.11.010openalex-snapshot
What will result from the interaction between functional and evolutionary biology?
inferred← citeshttps://doi.org/10.1016/j.shpsc.2012.01.002openalex-snapshot
What might be a new “view of evolution”?
inferred← citeshttps://doi.org/10.1016/j.str.2011.02.014openalex-snapshot
Tracing Protein Evolution through Ancestral Structures of Fish Galectin
inferred← citeshttps://doi.org/10.1016/j.synbio.2017.10.004openalex-snapshot
Experimental evolution and proximate mechanisms in biology
inferred← citeshttps://doi.org/10.1016/j.tig.2009.09.001openalex-snapshot
The need for molecular genetic perspectives in evolutionary education (and vice versa)
inferred← citeshttps://doi.org/10.1016/j.tig.2010.04.005openalex-snapshot
Hybrid incompatibility genes: remnants of a genomic battlefield?
inferred← citeshttps://doi.org/10.1016/j.tig.2010.06.005openalex-snapshot
Causes and evolutionary significance of genetic convergence
inferred← citeshttps://doi.org/10.1016/j.tig.2010.08.002openalex-snapshot
Moving from transcriptional to phospho-evolution: generalizing regulatory evolution?
inferred← citeshttps://doi.org/10.1016/j.tim.2019.02.003openalex-snapshot
Experimental Evolution as a Tool to Investigate Natural Processes and Molecular Functions
inferred← citeshttps://doi.org/10.1016/j.toxicon.2011.12.008openalex-snapshot
Activation of a tunicate (Ciona intestinalis) xenobiotic receptor orthologue by both natural toxins and synthetic toxicants
inferred← citeshttps://doi.org/10.1016/j.tree.2008.03.006openalex-snapshot
The gene regulatory logic of transcription factor evolution
inferred← citeshttps://doi.org/10.1016/j.yfrne.2017.07.003openalex-snapshot
Polymorphisms in sex steroid receptors: From gene sequence to behavior
inferred← citeshttps://doi.org/10.1016/j.ygcen.2023.114356openalex-snapshot
Functional characterization of melanocortin 2 receptor (Mc2r) from a lobe-finned fish (Protopterus annectens) and insights into the molecular evolution of melanocortin receptors
inferred← citeshttps://doi.org/10.1016/j.ygeno.2014.09.015openalex-snapshot
The enduring utility of continuous culturing in experimental evolution
inferred← citeshttps://doi.org/10.1016/j.ympev.2009.04.015openalex-snapshot
Phylogeny, taxonomy, and evolution of the endothelin receptor gene family
inferred← citeshttps://doi.org/10.1016/j.ympev.2014.01.020openalex-snapshot
Evolutionary dynamics of Polynucelotide phosphorylases
inferred← citeshttps://doi.org/10.1016/j.ympev.2018.01.009openalex-snapshot
Identification of epistatic mutations and insights into the evolution of the influenza virus using a mass-based protein phylogenetic approach
inferred← citeshttps://doi.org/10.1021/bi300694topenalex-snapshot
Reconstructing a Missing Link in the Evolution of a Recently Diverged Phosphotriesterase by Active-Site Loop Remodeling
inferred← citeshttps://doi.org/10.1021/bi3016185openalex-snapshot
A Population-Based Experimental Model for Protein Evolution: Effects of Mutation Rate and Selection Stringency on Evolutionary Outcomes
inferred← citeshttps://doi.org/10.1021/bi801932xopenalex-snapshot
Evolution in the Amidohydrolase Superfamily: Substrate-Assisted Gain of Function in the E183K Mutant of a Phosphotriesterase-like Metal-Carboxylesterase
inferred← citeshttps://doi.org/10.1038/463864aopenalex-snapshot
Evolution: Revenge of the hopeful monster
inferred← citeshttps://doi.org/10.1038/emboj.2008.184openalex-snapshot
Structural basis for LEAFY floral switch function and similarity with helix‐turn‐helix proteins
inferred← citeshttps://doi.org/10.1038/embor.2010.78openalex-snapshot
The future of molecular evolution
inferred← citeshttps://doi.org/10.1038/msb.2010.43openalex-snapshot
Evolutionary fates within a microbial population highlight an essential role for protein folding during natural selection
inferred← citeshttps://doi.org/10.1038/nature07529openalex-snapshot
Protein kinase R reveals an evolutionary model for defeating viral mimicry
inferred← citeshttps://doi.org/10.1038/nature08249openalex-snapshot
An epistatic ratchet constrains the direction of glucocorticoid receptor evolution
inferred← citeshttps://doi.org/10.1038/nature14207openalex-snapshot
Fitness tracking for adapting populations
inferred← citeshttps://doi.org/10.1038/nature17995openalex-snapshot
Local fitness landscape of the green fluorescent protein
inferred← citeshttps://doi.org/10.1038/nchembio0809-516openalex-snapshot
The far reaches of enzymology
inferred← citeshttps://doi.org/10.1038/ncomms12344openalex-snapshot
Evolution of a G protein-coupled receptor response by mutations in regulatory network interactions
inferred← citeshttps://doi.org/10.1038/ncomms12847openalex-snapshot
An experimental phylogeny to benchmark ancestral sequence reconstruction
inferred← citeshttps://doi.org/10.1038/ng.820openalex-snapshot
High-throughput identification of genetic interactions in HIV-1
inferred← citeshttps://doi.org/10.1038/nmeth.3027openalex-snapshot
Deep mutational scanning: a new style of protein science
inferred← citeshttps://doi.org/10.1038/nmeth1207-991openalex-snapshot
Protein engineers turned evolutionists
inferred← citeshttps://doi.org/10.1038/nrg2207openalex-snapshot
Which evolutionary processes influence natural genetic variation for phenotypic traits?
inferred← citeshttps://doi.org/10.1038/nrg2473openalex-snapshot
Neutralism and selectionism: a network-based reconciliation
inferred← citeshttps://doi.org/10.1038/nrg2499openalex-snapshot
The evolution of hierarchical gene regulatory networks
inferred← citeshttps://doi.org/10.1038/nrg2808openalex-snapshot
Mutational effects and the evolution of new protein functions
inferred← citeshttps://doi.org/10.1038/nrg3015openalex-snapshot
Molecular spandrels: tests of adaptation at the genetic level
inferred← citeshttps://doi.org/10.1038/nrg3033openalex-snapshot
Systems-biology approaches for predicting genomic evolution
inferred← citeshttps://doi.org/10.1038/nrg3540openalex-snapshot
Evolutionary biochemistry: revealing the historical and physical causes of protein properties
inferred← citeshttps://doi.org/10.1038/nrm2805openalex-snapshot
Exploring protein fitness landscapes by directed evolution
inferred← citeshttps://doi.org/10.1038/nrmicro2222openalex-snapshot
The evolutionary conundrum of pathogen mimicry
inferred← citeshttps://doi.org/10.1038/nsmb.1670openalex-snapshot
Following evolutionary paths to protein-protein interactions with high affinity and selectivity
inferred← citeshttps://doi.org/10.1038/s41467-024-54613-3openalex-snapshot
Evolutionary insights into the stereoselectivity of imine reductases based on ancestral sequence reconstruction
inferred← citeshttps://doi.org/10.1038/s41559-024-02582-7openalex-snapshot
Plasticity and environment-specific relationships between gene expression and fitness in Saccharomyces cerevisiae
inferred← citeshttps://doi.org/10.1038/s41586-024-07636-1openalex-snapshot
Spike deep mutational scanning helps predict success of SARS-CoV-2 clades
inferred← citeshttps://doi.org/10.1038/s41598-017-16332-2openalex-snapshot
The directed evolution of ligand specificity in a GPCR and the unequal contributions of efficacy and affinity
inferred← citeshttps://doi.org/10.1038/s41598-026-64001-0openalex-snapshot
Gene function predicts divergence across molecular levels
inferred← citeshttps://doi.org/10.1038/srep08193openalex-snapshot
Protein evolution analysis of S-hydroxynitrile lyase by complete sequence design utilizing the INTMSAlign software
inferred← citeshttps://doi.org/10.1038/srep20510openalex-snapshot
Evolutionary functional elaboration of the Elovl2/5 gene family in chordates
inferred← citeshttps://doi.org/10.1039/c9np00048hopenalex-snapshot
Evolutionary dynamics of natural product biosynthesis in bacteria
inferred← citeshttps://doi.org/10.1039/d1np00013fopenalex-snapshot
The confluence of big data and evolutionary genome mining for the discovery of natural products
inferred← citeshttps://doi.org/10.1042/bcj20161094openalex-snapshot
1-N-histidine phosphorylation of ChlD by the AAA+ ChlI2 stimulates magnesium chelatase activity in chlorophyll synthesis
inferred← citeshttps://doi.org/10.1042/bcj20170173openalex-snapshot
Comparative functional analysis of ribonuclease 1 homologs: molecular insights into evolving vertebrate physiology
inferred← citeshttps://doi.org/10.1042/bj20130205openalex-snapshot
Experimental evolution of protein–protein interaction networks
inferred← citeshttps://doi.org/10.1042/bst20120338openalex-snapshot
Sulfolobus islandicus: a model system for evolutionary genomics
inferred← citeshttps://doi.org/10.1042/bst20180626openalex-snapshot
The fitness challenge of studying molecular adaptation
inferred← citeshttps://doi.org/10.1051/jbio/2014027openalex-snapshot
La marche génétique de l’évolution
inferred← citeshttps://doi.org/10.1063/1.3453623openalex-snapshot
Evolution of a single gene highlights the complexity underlying molecular descriptions of fitness
inferred← citeshttps://doi.org/10.1073/pnas.0802426105openalex-snapshot
Elucidation of phenotypic adaptations: Molecular analyses of dim-light vision proteins in vertebrates
inferred← citeshttps://doi.org/10.1073/pnas.0807989106openalex-snapshot
Adaptive protein evolution grants organismal fitness by improving catalysis and flexibility
inferred← citeshttps://doi.org/10.1073/pnas.0900012106openalex-snapshot
Tat acetylation modulates assembly of a viral-host RNA–protein transcription complex
inferred← citeshttps://doi.org/10.1073/pnas.0905224106openalex-snapshot
Evolutionary and functional insights into the mechanism underlying high-altitude adaptation of deer mouse hemoglobin
inferred← citeshttps://doi.org/10.1073/pnas.0911042107openalex-snapshot
Molecular and functional basis of phenotypic convergence in white lizards at White Sands
inferred← citeshttps://doi.org/10.1073/pnas.0914026107openalex-snapshot
11-Deoxycortisol is a corticosteroid hormone in the lamprey
inferred← citeshttps://doi.org/10.1073/pnas.1100301108openalex-snapshot
Molecular evolutionary analyses of insect societies
inferred← citeshttps://doi.org/10.1073/pnas.1100990108openalex-snapshot
Evolution of a derived protein–protein interaction between HoxA11 and Foxo1a in mammals caused by changes in intramolecular regulation
inferred← citeshttps://doi.org/10.1073/pnas.1103457108openalex-snapshot
Genes involved in convergent evolution of eusociality in bees
inferred← citeshttps://doi.org/10.1073/pnas.1209335110openalex-snapshot
Small changes in enzyme function can lead to surprisingly large fitness effects during adaptive evolution of antibiotic resistance
inferred← citeshttps://doi.org/10.1073/pnas.1215206110openalex-snapshot
Capturing the mutational landscape of the beta-lactamase TEM-1
inferred← citeshttps://doi.org/10.1073/pnas.1303930110openalex-snapshot
Biophysical mechanisms for large-effect mutations in the evolution of steroid hormone receptors
inferred← citeshttps://doi.org/10.1073/pnas.1918680117openalex-snapshot
Collateral fitness effects of mutations
inferred← citeshttps://doi.org/10.1073/pnas.2301549120openalex-snapshot
Structural evolution of an immune evasion determinant shapes pathogen host tropism
inferred← citeshttps://doi.org/10.1073/pnas.2530587122openalex-snapshot
The neural substrates of behavioral evolution: Divergent behaviors from conserved neurons
inferred← citeshttps://doi.org/10.1074/jbc.m110.136911openalex-snapshot
Tryptophanyl-tRNA Synthetase Urzyme
inferred← citeshttps://doi.org/10.1074/jbc.m112.343814openalex-snapshot
Sorting of the Yeast Vacuolar-type, Proton-translocating ATPase Enzyme Complex (V-ATPase)
inferred← citeshttps://doi.org/10.1074/jbc.m115.702498openalex-snapshot
Evolution of Heat Sensors Drove Shifts in Thermosensation between Xenopus Species Adapted to Different Thermal Niches
inferred← citeshttps://doi.org/10.1074/jbc.m116.751214openalex-snapshot
Correlated evolution between CK1δ Protein and the Serine-rich Motif Contributes to Regulating the Mammalian Circadian Clock
inferred← citeshttps://doi.org/10.1074/jbc.r114.567495openalex-snapshot
Urzymology: Experimental Access to a Key Transition in the Appearance of Enzymes
inferred← citeshttps://doi.org/10.1080/10409230903039658openalex-snapshot
Revealing evolutionary pathways by fitness landscape reconstruction
inferred← citeshttps://doi.org/10.1080/23328940.2017.1315478openalex-snapshot
Evolutionary tuning of TRPA1 and TRPV1 thermal and chemical sensitivity in vertebrates
inferred← citeshttps://doi.org/10.1086/660020openalex-snapshot
Seeing the Forest for the Trees: The Limitations of Phylogenies in Comparative Biology
inferred← citeshttps://doi.org/10.1086/665975openalex-snapshot
Tests of the Link between Functional Innovation and Positive Selection at Phytochrome A: The Phylogenetic Distribution of Far-Red High-Irradiance Responses in Seedling Development
inferred← citeshttps://doi.org/10.1086/714959openalex-snapshot
Toward a Theory of Homology: Development and the De-Coupling of Morphological and Molecular Evolution
inferred← citeshttps://doi.org/10.1091/mbc.e11-03-0244openalex-snapshot
The reconstructed ancestral subunit a functions as both V-ATPase isoforms Vph1p and Stv1p inSaccharomyces cerevisiae
inferred← citeshttps://doi.org/10.1093/acprof:oso/9780199568765.003.0012openalex-snapshot
Patterns and processes of human life history evolution
inferred← citeshttps://doi.org/10.1093/acprof:oso/9780199602605.001.0001openalex-snapshot
Molecular Evolution
inferred← citeshttps://doi.org/10.1093/acprof:oso/9780199602605.002.0003openalex-snapshot
Copyright Page
inferred← citeshttps://doi.org/10.1093/acprof:oso/9780199602605.003.0001openalex-snapshot
Models of nucleotide substitution
inferred← citeshttps://doi.org/10.1093/acprof:oso/9780199602605.003.0002openalex-snapshot
Models of amino acid and codon substitution
inferred← citeshttps://doi.org/10.1093/acprof:oso/9780199602605.003.0003openalex-snapshot
Phylogeny reconstruction: overview
inferred← citeshttps://doi.org/10.1093/acprof:oso/9780199602605.003.0004openalex-snapshot
Maximum likelihood methods
inferred← citeshttps://doi.org/10.1093/acprof:oso/9780199602605.003.0005openalex-snapshot
Comparison of phylogenetic methods and tests on trees
inferred← citeshttps://doi.org/10.1093/acprof:oso/9780199602605.003.0006openalex-snapshot
Bayesian theory
inferred← citeshttps://doi.org/10.1093/acprof:oso/9780199602605.003.0007openalex-snapshot
Bayesian computation (MCMC)
inferred← citeshttps://doi.org/10.1093/acprof:oso/9780199602605.003.0008openalex-snapshot
Bayesian phylogenetics
inferred← citeshttps://doi.org/10.1093/acprof:oso/9780199602605.003.0009openalex-snapshot
Coalescent theory and species trees
inferred← citeshttps://doi.org/10.1093/acprof:oso/9780199602605.003.0010openalex-snapshot
Molecular clock and estimation of species divergence times
inferred← citeshttps://doi.org/10.1093/acprof:oso/9780199602605.003.0011openalex-snapshot
Neutral and adaptive protein evolution
inferred← citeshttps://doi.org/10.1093/acprof:oso/9780199602605.003.0012openalex-snapshot
Simulating molecular evolution
inferred← citeshttps://doi.org/10.1093/bfgp/elp056openalex-snapshot
Lineage-specific transcription factors and the evolution of gene regulatory networks
inferred← citeshttps://doi.org/10.1093/bfgp/elv003openalex-snapshot
Integrating evo-devo with ecology for a better understanding of phenotypic evolution
inferred← citeshttps://doi.org/10.1093/gbe/evq012openalex-snapshot
Using Phylogenomic Patterns and Gene Ontology to Identify Proteins of Importance in Plant Evolution
inferred← citeshttps://doi.org/10.1093/gbe/evx120openalex-snapshot
Rapid Evolution of Primate Type 2 Immune Response Factors Linked to Asthma Susceptibility
inferred← citeshttps://doi.org/10.1093/gbe/evy191openalex-snapshot
Predicting Evolution of the Transcription Regulatory Network in a Bacteriophage
inferred← citeshttps://doi.org/10.1093/genetics/iyae191openalex-snapshot
Linking molecular mechanisms to their evolutionary consequences: a primer
inferred← citeshttps://doi.org/10.1093/genetics/iyag140openalex-snapshot
When evolvability meets constraint: reflections on empirical fitness landscapes after Weinreich et al. (2006)
inferred← citeshttps://doi.org/10.1093/icb/icaf117openalex-snapshot
Toward a Cross-Disciplinary Understanding of Urban Evolution
inferred← citeshttps://doi.org/10.1093/icb/icw040openalex-snapshot
Hormones and the Evolution of Complex Traits: Insights from Artificial Selection on Behavior
inferred← citeshttps://doi.org/10.1093/icb/icw082openalex-snapshot
Venom Resistance as a Model for Understanding the Molecular Basis of Complex Coevolutionary Adaptations
inferred← citeshttps://doi.org/10.1093/jxb/erw470openalex-snapshot
Evolution of jasmonate biosynthesis and signaling mechanisms
inferred← citeshttps://doi.org/10.1093/molbev/msab059openalex-snapshot
Convergent Biochemical Pathways for Xanthine Alkaloid Production in Plants Evolved from Ancestral Enzymes with Different Catalytic Properties
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