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The many roles of histone deacetylases in development and physiology: implications for disease and therapy

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Outgoing claims: the papers this work cites, builds on, or argues with.

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Efficiency assessment of the gene trap approach

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The new bone biology: Pathologic, molecular, and clinical correlates

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Histone deacetylase 1 (HDAC‐1) required for the normal formation of craniofacial cartilage and pectoral fins of the zebrafish

inferredcites →https://doi.org/10.1002/jnr.21521openalex-snapshot

Developmental expression of histone deacetylase 11 in the murine brain

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Valproic Acid Prevents Brain Injury in a Canine Model of Hypothermic Circulatory Arrest: A Promising New Approach to Neuroprotection During Cardiac Surgery

inferredcites →https://doi.org/10.1016/j.bmcl.2008.02.025openalex-snapshot

Probing the elusive catalytic activity of vertebrate class IIa histone deacetylases

inferredcites →https://doi.org/10.1016/j.bmcl.2008.02.026openalex-snapshot

2-Trifluoroacetylthiophenes, a novel series of potent and selective class II histone deacetylase inhibitors

inferredcites →https://doi.org/10.1016/j.brainres.2008.05.085openalex-snapshot

HDAC inhibitor increases histone H3 acetylation and reduces microglia inflammatory response following traumatic brain injury in rats

inferredcites →https://doi.org/10.1016/j.cell.2004.10.024openalex-snapshot

Histone Deacetylase 4 Controls Chondrocyte Hypertrophy during Skeletogenesis

inferredcites →https://doi.org/10.1016/j.cell.2006.02.048openalex-snapshot

The Transcriptional Coactivator CAMTA2 Stimulates Cardiac Growth by Opposing Class II Histone Deacetylases

inferredcites →https://doi.org/10.1016/j.cell.2006.05.040openalex-snapshot

Histone Deacetylase 7 Maintains Vascular Integrity by Repressing Matrix Metalloproteinase 10

inferredcites →https://doi.org/10.1016/j.cell.2006.07.002openalex-snapshot

Sirtuins in Aging and Age-Related Disease

inferredcites →https://doi.org/10.1016/j.cell.2007.07.034openalex-snapshot

Acetylation-Dependent Signal Transduction for Type I Interferon Receptor

inferredcites →https://doi.org/10.1016/j.cmet.2007.11.006openalex-snapshot

Conserved Metabolic Regulatory Functions of Sirtuins

inferredcites →https://doi.org/10.1016/j.devcel.2007.02.004openalex-snapshot

MEF2C Transcription Factor Controls Chondrocyte Hypertrophy and Bone Development

inferredcites →https://doi.org/10.1016/j.jneuroim.2005.02.022openalex-snapshot

Transcriptional therapy with the histone deacetylase inhibitor trichostatin A ameliorates experimental autoimmune encephalomyelitis

inferredcites →https://doi.org/10.1016/j.mod.2005.10.005openalex-snapshot

Histone deacetylase 1 is essential for oligodendrocyte specification in the zebrafish CNS

inferredcites →https://doi.org/10.1016/j.mod.2007.07.003openalex-snapshot

Zebrafish colgate/hdac1 functions in the non-canonical Wnt pathway during axial extension and in Wnt-independent branchiomotor neuron migration

inferredcites →https://doi.org/10.1016/j.molcel.2005.04.021openalex-snapshot

HDAC6 Regulates Hsp90 Acetylation and Chaperone-Dependent Activation of Glucocorticoid Receptor

inferredcites →https://doi.org/10.1016/j.molcel.2006.06.017openalex-snapshot

Enhanced Histone Acetylation and Transcription: A Dynamic Perspective

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Substrate and Functional Diversity of Lysine Acetylation Revealed by a Proteomics Survey

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HDAC6 Modulates Cell Motility by Altering the Acetylation Level of Cortactin

inferredcites →https://doi.org/10.1016/j.molcel.2008.02.030openalex-snapshot

Deletion of Histone Deacetylase 3 Reveals Critical Roles in S Phase Progression and DNA Damage Control

inferredcites →https://doi.org/10.1016/j.surg.2008.03.034openalex-snapshot

Acetylation: a novel method for modulation of the immune response following trauma/hemorrhage and inflammatory second hit in animals and humans

inferredcites →https://doi.org/10.1016/j.ydbio.2008.02.034openalex-snapshot

Histone deacetylase 3 (hdac3) is specifically required for liver development in zebrafish

inferredcites →https://doi.org/10.1016/j.yjmcc.2006.08.010openalex-snapshot

Class II HDACs mediate CaMK-dependent signaling to NRSF in ventricular myocytes

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Class II Histone Deacetylases Act as Signal-Responsive Repressors of Cardiac Hypertrophy

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Hop Is an Unusual Homeobox Gene that Modulates Cardiac Development

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Modulation of Cardiac Growth and Development by HOP, an Unusual Homeodomain Protein

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Depletion of latent HIV-1 infection in vivo: a proof-of-concept study

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Acetylation and chromosomal functions

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Collaborative spirit of histone deacetylases in regulating chromatin structure and gene expression

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Regulation of Skeletal Myogenesis by Association of the MEF2 Transcription Factor with Class II Histone Deacetylases

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Enzymatic Activity Associated with Class II HDACs Is Dependent on a Multiprotein Complex Containing HDAC3 and SMRT/N-CoR

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A therapeutic strategy uses histone deacetylase inhibitors to modulate the expression of genes involved in the pathogenesis of rheumatoid arthritis

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Quantitative Analysis of Histone Deacetylase-1 Selective Histone Modifications by Differential Mass Spectrometry

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Signal-dependent nuclear export of a histone deacetylase regulates muscle differentiation

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Histone acetylation in chromatin structure and transcription

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HDAC6 is a microtubule-associated deacetylase

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Liver‐specific deletion of histone deacetylase 3 disrupts metabolic transcriptional networks

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The complexities of skeletal biology

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The MAPK Hog1 recruits Rpd3 histone deacetylase to activate osmoresponsive genes

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Sirtuins as potential targets for metabolic syndrome

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Recovery of learning and memory is associated with chromatin remodelling

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Dimethyl sulfoxide to vorinostat: development of this histone deacetylase inhibitor as an anticancer drug

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Functional and morphological recovery of dystrophic muscles in mice treated with deacetylase inhibitors

inferredcites →https://doi.org/10.1038/nm1552openalex-snapshot

Hdac2 regulates the cardiac hypertrophic response by modulating Gsk3β activity

inferredcites →https://doi.org/10.1038/nn1408openalex-snapshot

Histone deacetylase 9 couples neuronal activity to muscle chromatin acetylation and gene expression

inferredcites →https://doi.org/10.1038/nrd2133openalex-snapshot

Anticancer activities of histone deacetylase inhibitors

inferredcites →https://doi.org/10.1038/nrm1075openalex-snapshot

Histone acetylation and deacetylation in yeast

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Calorie restriction, SIRT1 and metabolism: understanding longevity

inferredcites →https://doi.org/10.1038/nrm2298openalex-snapshot

Multivalent engagement of chromatin modifications by linked binding modules

inferredcites →https://doi.org/10.1038/nrm2346openalex-snapshot

The Rpd3/Hda1 family of lysine deacetylases: from bacteria and yeast to mice and men

inferredcites →https://doi.org/10.1038/sj.onc.1205291openalex-snapshot

Complex roles of tissue inhibitors of metalloproteinases in cancer

inferredcites →https://doi.org/10.1038/sj.onc.1209417openalex-snapshot

Modulation of cellular radiation responses by histone deacetylase inhibitors

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Discovery and development of SAHA as an anticancer agent

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Histone deacetylase inhibitors: molecular mechanisms of action

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Targeted Therapy for Inherited GPI Deficiency

inferredcites →https://doi.org/10.1056/nejmra072139openalex-snapshot

Cardiac Plasticity

inferredcites →https://doi.org/10.1073/pnas.0400380101openalex-snapshot

Histone deacetylase inhibitor suberoylanilide hydroxamic acid reduces acute graft-versus-host disease and preserves graft-versus-leukemia effect

inferredcites →https://doi.org/10.1073/pnas.0706487104openalex-snapshot

Unraveling the hidden catalytic activity of vertebrate class IIa histone deacetylases

inferredcites →https://doi.org/10.1073/pnas.080064097openalex-snapshot

Signal-dependent activation of the MEF2 transcription factor by dissociation from histone deacetylases

inferredcites →https://doi.org/10.1073/pnas.131198498openalex-snapshot

The transcriptional corepressor MITR is a signal-responsive inhibitor of myogenesis

inferredcites →https://doi.org/10.1073/pnas.93.25.14503openalex-snapshot

HDA1 and RPD3 are members of distinct yeast histone deacetylase complexes that regulate silencing and transcription

inferredcites →https://doi.org/10.1074/jbc.c000304200openalex-snapshot

Calcium Regulates Transcriptional Repression of Myocyte Enhancer Factor 2 by Histone Deacetylase 4

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Association of COOH-terminal-binding Protein (CtBP) and MEF2-interacting Transcription Repressor (MITR) Contributes to Transcriptional Repression of the MEF2 Transcription Factor

inferredcites →https://doi.org/10.1074/jbc.m101508200openalex-snapshot

A Dynamic Role for HDAC7 in MEF2-mediated Muscle Differentiation

inferredcites →https://doi.org/10.1074/jbc.m108055200openalex-snapshot

Isolation and Characterization of a Novel Class II Histone Deacetylase, HDAC10

inferredcites →https://doi.org/10.1074/jbc.m109861200openalex-snapshot

Molecular Cloning and Characterization of a Novel Histone Deacetylase HDAC10

inferredcites →https://doi.org/10.1074/jbc.m111871200openalex-snapshot

Cloning and Functional Characterization of HDAC11, a Novel Member of the Human Histone Deacetylase Family

inferredcites →https://doi.org/10.1074/jbc.m303113200openalex-snapshot

Dose-dependent Blockade to Cardiomyocyte Hypertrophy by Histone Deacetylase Inhibitors

inferredcites →https://doi.org/10.1074/jbc.m707362200openalex-snapshot

Human HDAC7 Harbors a Class IIa Histone Deacetylase-specific Zinc Binding Motif and Cryptic Deacetylase Activity

inferredcites →https://doi.org/10.1074/jbc.m803514200openalex-snapshot

Structural and Functional Analysis of the Human HDAC4 Catalytic Domain Reveals a Regulatory Structural Zinc-binding Domain

inferredcites →https://doi.org/10.1074/jbc.m803686200openalex-snapshot

Transgenic Overexpression of Hdac3 in the Heart Produces Increased Postnatal Cardiac Myocyte Proliferation but Does Not Induce Hypertrophy

inferredcites →https://doi.org/10.1080/003655202317316105openalex-snapshot

Butyrate Inhibits NF-κB Activation in Lamina Propria Macrophages of Patients with Ulcerative Colitis

inferredcites →https://doi.org/10.1080/07853890310001285openalex-snapshot

Extracellular matrix remodeling following myocardial injury

inferredcites →https://doi.org/10.1093/emboj/18.18.5085openalex-snapshot

MEF‐2 function is modified by a novel co‐repressor, MITR

inferredcites →https://doi.org/10.1093/emboj/18.18.5099openalex-snapshot

HDAC4 deacetylase associates with and represses the MEF2 transcription factor

inferredcites →https://doi.org/10.1093/emboj/19.6.1176openalex-snapshot

Acetylation: a regulatory modification to rival phosphorylation?

inferredcites →https://doi.org/10.1093/emboj/21.11.2672openalex-snapshot

Essential function of histone deacetylase 1 in proliferation control and CDK inhibitor repression

inferredcites →https://doi.org/10.1093/emboj/cdf682openalex-snapshot

In vivo destabilization of dynamic microtubules by HDAC6‐mediated deacetylation

inferredcites →https://doi.org/10.1093/emboj/cdg601openalex-snapshot

NRSF regulates the fetal cardiac gene program and maintains normal cardiac structure and function

inferredcites →https://doi.org/10.1096/fj.08-108548openalex-snapshot

Histone deacetylase inhibition reduces myocardial ischemia‐reperfusion injury in mice

inferredcites →https://doi.org/10.1101/gad.1563807openalex-snapshot

Histone deacetylases 1 and 2 redundantly regulate cardiac morphogenesis, growth, and contractility

inferredcites →https://doi.org/10.1111/j.1365-2222.2004.02006.xopenalex-snapshot

Trichostatin A attenuates airway inflammation in mouse asthma model

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Requirement of Hos2 Histone Deacetylase for Gene Activity in Yeast

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A Mammalian Histone Deacetylase Related to the Yeast Transcriptional Regulator Rpd3p

inferredcites →https://doi.org/10.1126/stke.2962005re11openalex-snapshot

Histone Deacetylases as Transcriptional Activators? Role Reversal in Inducible Gene Regulation

inferredcites →https://doi.org/10.1128/mcb.00189-08openalex-snapshot

Protein Kinase D1 Stimulates MEF2 Activity in Skeletal Muscle and Enhances Muscle Performance

inferredcites →https://doi.org/10.1128/mcb.01154-06openalex-snapshot

Mice Lacking Histone Deacetylase 6 Have Hyperacetylated Tubulin but Are Viable and Develop Normally

inferredcites →https://doi.org/10.1128/mcb.01220-06openalex-snapshot

Negative and Positive Regulation of Gene Expression by Mouse Histone Deacetylase 1

inferredcites →https://doi.org/10.1128/mcb.01415-06openalex-snapshot

Regulation of HDAC9 Gene Expression by MEF2 Establishes a Negative-Feedback Loop in the Transcriptional Circuitry of Muscle Differentiation

inferredcites →https://doi.org/10.1128/mcb.19.11.7816openalex-snapshot

HDAC4, a Human Histone Deacetylase Related to Yeast HDA1, Is a Transcriptional Corepressor

inferredcites →https://doi.org/10.1128/mcb.21.6.2085-2097.2001openalex-snapshot

The Neuron-Restrictive Silencer Element–Neuron-Restrictive Silencer Factor System Regulates Basal and Endothelin 1-Inducible Atrial Natriuretic Peptide Gene Expression in Ventricular Myocytes

inferredcites →https://doi.org/10.1128/mcb.22.20.7302-7312.2002openalex-snapshot

Association of Class II Histone Deacetylases with Heterochromatin Protein 1: Potential Role for Histone Methylation in Control of Muscle Differentiation

inferredcites →https://doi.org/10.1128/mcb.24.19.8374-8385.2004openalex-snapshot

Protein Kinases C and D Mediate Agonist-Dependent Cardiac Hypertrophy through Nuclear Export of Histone Deacetylase 5

inferredcites →https://doi.org/10.1128/mcb.24.19.8467-8476.2004openalex-snapshot

Histone Deacetylases 5 and 9 Govern Responsiveness of the Heart to a Subset of Stress Signals and Play Redundant Roles in Heart Development

inferredcites →https://doi.org/10.1146/annurev.biochem.75.103004.142622openalex-snapshot

Signaling Pathways in Skeletal Muscle Remodeling

inferredcites →https://doi.org/10.1146/annurev.biochem.76.052705.162114openalex-snapshot

Functions of Site-Specific Histone Acetylation and Deacetylation

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Reduced Body Size and Decreased Intestinal Tumor Rates in HDAC2-Mutant Mice

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Control of Cardiac Growth by Histone Acetylation/Deacetylation

inferredcites →https://doi.org/10.1161/circulationaha.106.625467openalex-snapshot

Suppression of Class I and II Histone Deacetylases Blunts Pressure-Overload Cardiac Hypertrophy

inferredcites →https://doi.org/10.1172/jci16153openalex-snapshot

Histone deacetylase inhibitors modulate renal disease in the MRL-lpr/lpr mouse

inferredcites →https://doi.org/10.1172/jci19137openalex-snapshot

Cardiac hypertrophy and histone deacetylase–dependent transcriptional repression mediated by the atypical homeodomain protein Hop

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Toward transcriptional therapies for the failing heart: chemical screens to modulate genes

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CaM kinase II selectively signals to histone deacetylase 4 during cardiomyocyte hypertrophy

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Trichostatin A increases SMN expression and survival in a mouse model of spinal muscular atrophy

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Histone deacetylase degradation andMEF2 activation promote the formation of slow-twitch myofibers

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The MEF2D transcription factor mediates stress-dependent cardiac remodeling in mice

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Histone deacetylase inhibition modulates indoleamine 2,3-dioxygenase–dependent DC functions and regulates experimental graft-versus-host disease in mice

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Maintenance of cardiac energy metabolism by histone deacetylase 3 in mice

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CaM kinase signaling induces cardiac hypertrophy and activates the MEF2 transcription factor in vivo

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Phase 2 trial of oral vorinostat (suberoylanilide hydroxamic acid, SAHA) for refractory cutaneous T-cell lymphoma (CTCL)

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Sustained induction of fetal hemoglobin by pulse butyrate therapy in sickle cell disease.

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PTHrP and Skeletal Development

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Phase IIB Multicenter Trial of Vorinostat in Patients With Persistent, Progressive, or Treatment Refractory Cutaneous T-Cell Lymphoma

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Histone deacetylase 1 is required to repress Notch target gene expression during zebrafish neurogenesis and to maintain the production of motoneurones in response to hedgehog signalling

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Histone deacetylase 1 regulates retinal neurogenesis in zebrafish by suppressing Wnt and Notch signaling pathways

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FDA Approval Summary: Vorinostat for Treatment of Advanced Primary Cutaneous T-Cell Lymphoma

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The Histone Deacetylase Inhibitor ITF2357 Reduces Production of Pro-Inflammatory Cytokines In Vitro and Systemic Inflammation In Vivo

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Histone Hyperacetylation Is Associated with Amelioration of Experimental Colitis in Mice

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Incoming claims: where this work appears in other papers’ reference lists and arguments.

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inferred← citeshttps://doi.org/10.1002/anie.202203243openalex-snapshot

A Reactivity‐Tunable Self‐Immolative Design Enables Histone Deacetylase‐Targeted Imaging and Prodrug Activation

inferred← citeshttps://doi.org/10.1002/anie.202215460openalex-snapshot

Synthesis, Biochemical Characterization, and Genetic Encoding of a 1,2,4‐Triazole Amino Acid as an Acetyllysine Mimic for Bromodomains of the BET Family

inferred← citeshttps://doi.org/10.1002/anie.202510967openalex-snapshot

Interactome Profiling of a Lysine Deacetylase Trapping Probe Library Uncovers Crosstalk Between HDAC6 and NF‐κB Signaling

inferred← citeshttps://doi.org/10.1002/ar.24252openalex-snapshot

USP7 Deubiquitinates and Stabilizes SIRT1

inferred← citeshttps://doi.org/10.1002/arch.21614openalex-snapshot

Inhibition of histone acetylation and deacetylation enzymes affects longevity, development, and fecundity in the pea aphid (Acyrthosiphon pisum)

inferred← citeshttps://doi.org/10.1002/bdr2.1564openalex-snapshot

Nucleic acid methylation and orofacial morphogenesis

inferred← citeshttps://doi.org/10.1002/bdr2.1666openalex-snapshot

Gestational exposure to valproic acid upregulates total Stat3 protein expression while downregulating phosphorylated Stat3 in CD‐1 mouse embryos with neural tube defects

inferred← citeshttps://doi.org/10.1002/bdra.20774openalex-snapshot

Dynamics of Polycomb and Trithorax activities during development

inferred← citeshttps://doi.org/10.1002/bdrc.20209openalex-snapshot

Zebrafish kidney development: Basic science to translational research

inferred← citeshttps://doi.org/10.1002/bdrc.21060openalex-snapshot

The chondrocytic journey in endochondral bone growth and skeletal dysplasia

inferred← citeshttps://doi.org/10.1002/bies.201000061openalex-snapshot

Epigenetic cancer therapy: Proof of concept and remaining challenges

inferred← citeshttps://doi.org/10.1002/bies.201600070openalex-snapshot

Histone deacetylase inhibitors for cancer therapy: An evolutionarily ancient resistance response may explain their limited success

inferred← citeshttps://doi.org/10.1002/bies.201800078openalex-snapshot

Histone Lysine and Genomic Targets of Histone Acetyltransferases in Mammals

inferred← citeshttps://doi.org/10.1002/bies.201800167openalex-snapshot

Does N‐Terminal Protein Acetylation Lead to Protein Degradation?

inferred← citeshttps://doi.org/10.1002/bies.201900045openalex-snapshot

Initiated by CREB: Resolving Gene Regulatory Programs in Learning and Memory

inferred← citeshttps://doi.org/10.1002/bip.22135openalex-snapshot

HDAC8 substrates: Histones and beyond

inferred← citeshttps://doi.org/10.1002/bmc.3001openalex-snapshot

Determination of chidamide in rat plasma by LC‐MS and its application to pharmacokinetics study

inferred← citeshttps://doi.org/10.1002/cac2.12180openalex-snapshot

KDELR2 promotes breast cancer proliferation via HDAC3‐mediated cell cycle progression

inferred← citeshttps://doi.org/10.1002/cbdv.201400314openalex-snapshot

Restoring Histone Deacetylase Activity by Waste Product Release. A View from Molecular Mechanics Simulations with Mammalian HDAC8

inferred← citeshttps://doi.org/10.1002/cbf.3151openalex-snapshot

Stress response factors as hub‐regulators of microRNA biogenesis: implication to the diseased heart

inferred← citeshttps://doi.org/10.1002/cbic.201600519openalex-snapshot

Natural and Synthetic Macrocyclic Inhibitors of the Histone Deacetylase Enzymes

inferred← citeshttps://doi.org/10.1002/cbic.201800797openalex-snapshot

Optimal Substrate‐Trapping Mutants to Discover Substrates of HDAC1

inferred← citeshttps://doi.org/10.1002/cbic.201900339openalex-snapshot

Peptide‐Based 2‐Aminophenylamide Probes for Targeting Endogenous Class I Histone Deacetylase Complexes

inferred← citeshttps://doi.org/10.1002/cbic.202000459openalex-snapshot

Advances and Opportunities in Epigenetic Chemical Biology

inferred← citeshttps://doi.org/10.1002/cbin.10413openalex-snapshot

c‐Abl induces stabilization of histone deacetylase 1 (HDAC1) in a kinase activity‐dependent manner

inferred← citeshttps://doi.org/10.1002/cbin.11931openalex-snapshot

Dynamics of metabolism and regulation of epigenetics during cardiomyocytes maturation

inferred← citeshttps://doi.org/10.1002/cbin.11952openalex-snapshot

Celastrol acts as a new histone deacetylase inhibitor to inhibit colorectal cancer cell growth via regulating macrophage polarity

inferred← citeshttps://doi.org/10.1002/chem.201604167openalex-snapshot

Synthesis of Potent and Selective HDAC6 Inhibitors Bearing a Cyclohexane‐ or Cycloheptane‐Annulated 1,5‐Benzothiazepine Scaffold

inferred← citeshttps://doi.org/10.1002/cmdc.201200193openalex-snapshot

Design, Synthesis, and Biological Evaluation of 2‐Aminobenzanilide Derivatives as Potent and Selective HDAC Inhibitors

inferred← citeshttps://doi.org/10.1002/cmdc.201300005openalex-snapshot

tert‐Butylcarbamate‐Containing Histone Deacetylase Inhibitors: Apoptosis Induction, Cytodifferentiation, and Antiproliferative Activities in Cancer Cells

inferred← citeshttps://doi.org/10.1002/cmdc.201300413openalex-snapshot

Towards Selective Inhibition of Histone Deacetylase Isoforms: What Has Been Achieved, Where We Are and What Will Be Next

inferred← citeshttps://doi.org/10.1002/cmdc.201300433openalex-snapshot

The Effect of Various Zinc Binding Groups on Inhibition of Histone Deacetylases 1–11

inferred← citeshttps://doi.org/10.1002/cmdc.201300444openalex-snapshot

Lysine Deacetylase (KDAC) Regulatory Pathways: an Alternative Approach to Selective Modulation

inferred← citeshttps://doi.org/10.1002/cmdc.201500019openalex-snapshot

Hybrids from Farnesylthiosalicylic Acid and Hydroxamic Acid as Dual Ras‐Related Signaling and Histone Deacetylase (HDAC) Inhibitors: Design, Synthesis and Biological Evaluation

inferred← citeshttps://doi.org/10.1002/cmdc.201700449openalex-snapshot

Design, Synthesis, Molecular Modeling, and Biological Evaluation of Novel Amine‐based Histone Deacetylase Inhibitors

inferred← citeshttps://doi.org/10.1002/cmdc.201900114openalex-snapshot

Structurally Diverse Histone Deacetylase Photoreactive Probes: Design, Synthesis, and Photolabeling Studies in Live Cells and Tissue

inferred← citeshttps://doi.org/10.1002/cmdc.202000934openalex-snapshot

Strategies To Design Selective Histone Deacetylase Inhibitors

inferred← citeshttps://doi.org/10.1002/cmdc.202001011openalex-snapshot

Oxa Analogues of Nexturastat A Demonstrate Improved HDAC6 Selectivity and Superior Antileukaemia Activity

inferred← citeshttps://doi.org/10.1002/cmdc.70270openalex-snapshot

Fair and Square: Design, Synthesis and Biological Evaluations of Squaric Acid Derivatives as Novel HDAC8 Inhibitors

inferred← citeshttps://doi.org/10.1002/cne.22241openalex-snapshot

Regional and subcellular distribution of HDAC4 in mouse brain

inferred← citeshttps://doi.org/10.1002/cphy.c160021openalex-snapshot

Pathophysiological Fundamentals of Diabetic Cardiomyopathy

inferred← citeshttps://doi.org/10.1002/cplu.201600413openalex-snapshot

Anticancer RuII and RhIII Piano‐Stool Complexes that are Histone Deacetylase Inhibitors

inferred← citeshttps://doi.org/10.1002/cpz1.746openalex-snapshot

New Histone Lysine Acylation Biomarkers and Their Roles in Epigenetic Regulation

inferred← citeshttps://doi.org/10.1002/ddr.22026openalex-snapshot

Progress of small molecules for targeted protein degradation: PROTACs and other technologies

inferred← citeshttps://doi.org/10.1002/dneu.22480openalex-snapshot

Visual experience dependent regulation of neuronal structure and function by histone deacetylase 1 in developing Xenopus tectum in vivo

inferred← citeshttps://doi.org/10.1002/dvdy.23906openalex-snapshot

Regulation of Primitive Hematopoiesis by Class I Histone Deacetylases

inferred← citeshttps://doi.org/10.1002/dvdy.24563openalex-snapshot

Histone deacetylase 1 and 2 are essential for murine neural crest proliferation, pharyngeal arch development, and craniofacial morphogenesis

inferred← citeshttps://doi.org/10.1002/dvdy.24632openalex-snapshot

Calcium signals act through histone deacetylase to mediate pronephric kidney morphogenesis

inferred← citeshttps://doi.org/10.1002/eji.201242413openalex-snapshot

Deacetylation of C / EBP β is required for IL ‐4‐induced arginase‐1 expression in murine macrophages

inferred← citeshttps://doi.org/10.1002/ejoc.201601023openalex-snapshot

Total Synthesis of the Depsipeptide FR901375 and Preliminary Evaluation of Its Biological Activity

inferred← citeshttps://doi.org/10.1002/ejp.925openalex-snapshot

Epigenetic suppression of potassium‐chloride co‐transporter 2 expression in inflammatory pain induced by complete Freund's adjuvant (CFA)

inferred← citeshttps://doi.org/10.1002/embj.201387224openalex-snapshot

Regulation of G6PD acetylation by SIRT2 and KAT9 modulates NADPH homeostasis and cell survival during oxidative stress#

inferred← citeshttps://doi.org/10.1002/hed.24699openalex-snapshot

Effect of the histone deacetylase inhibitor resminostat on head and neck squamous cell carcinoma cell lines

inferred← citeshttps://doi.org/10.1002/hep.24606openalex-snapshot

The histone deacetylase 4/SP1/microrna-200a regulatory network contributes to aberrant histone acetylation in hepatocellular carcinoma

inferred← citeshttps://doi.org/10.1002/hep.26542openalex-snapshot

Loss of histone deacetylases 1 and 2 in hepatocytes impairs murine liver regeneration through Ki67 depletion

inferred← citeshttps://doi.org/10.1002/hep.27677openalex-snapshot

Farnesoid X receptor–induced lysine‐specific histone demethylase reduces hepatic bile acid levels and protects the liver against bile acid toxicity

inferred← citeshttps://doi.org/10.1002/ijc.27876openalex-snapshot

HDAC11 is a novel drug target in carcinomas

inferred← citeshttps://doi.org/10.1002/j.2040-4603.2017.tb00752.xopenalex-snapshot

Pathophysiological Fundamentals of Diabetic Cardiomyopathy

inferred← citeshttps://doi.org/10.1002/jbm4.10021openalex-snapshot

Parathyroid Hormone Signaling in Osteocytes

inferred← citeshttps://doi.org/10.1002/jbmr.2381openalex-snapshot

HDAC5 Controls MEF2C-Driven Sclerostin Expression in Osteocytes

inferred← citeshttps://doi.org/10.1002/jbmr.3236openalex-snapshot

Histone Deacetylase 3 Deletion in Mesenchymal Progenitor Cells Hinders Long Bone Development

inferred← citeshttps://doi.org/10.1002/jbmr.426openalex-snapshot

Histone deacetylase inhibitor MS-275 stimulates bone formation in part by enhancing Dhx36-mediated TNAP transcription

inferred← citeshttps://doi.org/10.1002/jcb.22397openalex-snapshot

Suberoylanilide hydroxamic acid (SAHA) at subtoxic concentrations increases the adhesivity of human leukemic cells to fibronectin

inferred← citeshttps://doi.org/10.1002/jcb.22415openalex-snapshot

Oxidative stress drives disulfide bond formation between basic helix‐loop‐helix transcription factors

inferred← citeshttps://doi.org/10.1002/jcb.22644openalex-snapshot

Role of histone acetylation in the development of diabetic retinopathy and the metabolic memory phenomenon

inferred← citeshttps://doi.org/10.1002/jcb.24802openalex-snapshot

Class II HDACs and Neuronal Regeneration

inferred← citeshttps://doi.org/10.1002/jcb.25902openalex-snapshot

Sodium Butyrate Protects Against High Fat Diet-Induced Cardiac Dysfunction and Metabolic Disorders in Type II Diabetic Mice

inferred← citeshttps://doi.org/10.1002/jcb.26022openalex-snapshot

Histone Modifications Pattern Associated With a State of Mesenchymal Stem Cell Cultures Derived From Amniotic Fluid of Normal and Fetus‐Affected Gestations

inferred← citeshttps://doi.org/10.1002/jcb.27320openalex-snapshot

Correlation between HDAC4 enhancer DNA methylation and mRNA expression during palatal fusion induced by all‐trans retinoic acid

inferred← citeshttps://doi.org/10.1002/jcb.29583openalex-snapshot

Exploring the binding mechanism of HDAC8 selective inhibitors: Lessons from the modification of Cap group

inferred← citeshttps://doi.org/10.1002/jcp.22679openalex-snapshot

The regulatory role of histone deacetylase inhibitors in Fgf4 expression is dependent on the differentiation state of pluripotent stem cells

inferred← citeshttps://doi.org/10.1002/jcp.24522openalex-snapshot

Epigenetics and Ocular Diseases: From Basic Biology to Clinical Study

inferred← citeshttps://doi.org/10.1002/jcp.24871openalex-snapshot

HDAC4 Degradation Mediates HDAC Inhibition‐Induced Protective Effects Against Hypoxia/Reoxygenation Injury

inferred← citeshttps://doi.org/10.1002/jcp.25401openalex-snapshot

Epigenetics in Intestinal Epithelial Cell Renewal

inferred← citeshttps://doi.org/10.1002/jcp.26148openalex-snapshot

Loss of Hdac3 in osteoprogenitors increases bone expression of osteoprotegerin, improving systemic insulin sensitivity

inferred← citeshttps://doi.org/10.1002/jcp.30053openalex-snapshot

Inhibition of Class IIa HDACs improves endothelial barrier function in endotoxin‐induced acute lung injury

inferred← citeshttps://doi.org/10.1002/jcp.30286openalex-snapshot

The role of HDAC11 in obesity‐related metabolic disorders: A critical review

inferred← citeshttps://doi.org/10.1002/jcp.31435openalex-snapshot

Research advances in protein lysine 2‐hydroxyisobutyrylation: From mechanistic regulation to disease relevance

inferred← citeshttps://doi.org/10.1002/jcsm.12891openalex-snapshot

Cytoplasmic HDAC4 regulates the membrane repair mechanism in Duchenne muscular dystrophy

inferred← citeshttps://doi.org/10.1002/jnr.23170openalex-snapshot

Conditional deletion of histone deacetylase‐4 in the central nervous system has no major effect on brain architecture or neuronal viability

inferred← citeshttps://doi.org/10.1002/jnr.24132openalex-snapshot

Non‐invasive diagnosis and treatment strategies for traumatic brain injury: an update

inferred← citeshttps://doi.org/10.1002/kjm2.12272openalex-snapshot

MiR ‐451a ameliorates alcoholic hepatitis via repressing HDAC8 ‐mediated proinflammatory response

inferred← citeshttps://doi.org/10.1002/mco2.261openalex-snapshot

Protein posttranslational modifications in health and diseases: Functions, regulatory mechanisms, and therapeutic implications

inferred← citeshttps://doi.org/10.1002/mco2.670openalex-snapshot

Epigenetic reprogramming in gastrointestinal cancer: biology and translational perspectives

inferred← citeshttps://doi.org/10.1002/mco2.70566openalex-snapshot

Melanoma: Pathogenesis and Targeted Therapy

inferred← citeshttps://doi.org/10.1002/med.20178openalex-snapshot

NAD+-dependent histone deacetylases (sirtuins) as novel therapeutic targets

inferred← citeshttps://doi.org/10.1002/med.21402openalex-snapshot

Therapeutic Strategies and Pharmacological Tools Influencing S1P Signaling and Metabolism

inferred← citeshttps://doi.org/10.1002/med.21436openalex-snapshot

The Current State of NAD+‐Dependent Histone Deacetylases (Sirtuins) as Novel Therapeutic Targets

inferred← citeshttps://doi.org/10.1002/med.21701openalex-snapshot

Histone deacetylases as targets for the treatment of neurodegenerative disorders: Challenges and future opportunities

inferred← citeshttps://doi.org/10.1002/med.70055openalex-snapshot

Hydroxamic Acids as HDAC Inhibitor Drug Leads for Malaria

inferred← citeshttps://doi.org/10.1002/mef2.35openalex-snapshot

Direct cellular targets and anticancer mechanisms of the natural product oridonin

inferred← citeshttps://doi.org/10.1002/mgg3.1557openalex-snapshot

A competing endogenous RNA network reveals key lncRNAs associated with sepsis

inferred← citeshttps://doi.org/10.1002/minf.201800083openalex-snapshot

Combined Ligand and Fragment‐based Drug Design of Selective Histone Deacetylase – 6 Inhibitors

inferred← citeshttps://doi.org/10.1002/minf.202000163openalex-snapshot

Pharmacoinformatic Investigation of Medicinal Plants from East Africa

inferred← citeshttps://doi.org/10.1002/mnfr.201000547openalex-snapshot

Differential effects of sulforaphane on histone deacetylases, cell cycle arrest and apoptosis in normal prostate cells versus hyperplastic and cancerous prostate cells

inferred← citeshttps://doi.org/10.1002/mnfr.201500867openalex-snapshot

The bounty of nature for changing the cancer landscape

inferred← citeshttps://doi.org/10.1002/mrd.23659openalex-snapshot

The role of histone deacetylases in embryonic development

inferred← citeshttps://doi.org/10.1002/mus.24912openalex-snapshot

Differential expression of HDAC and HAT genes in atrophying skeletal muscle

inferred← citeshttps://doi.org/10.1002/open.202500356openalex-snapshot

Design and Synthesis of Polyamine‐Proteolysis Targeting Chimera Conjugates for Histone Deacetylase (HDAC) Degradation with Enhanced Cellular Uptake

inferred← citeshttps://doi.org/10.1002/path.4234openalex-snapshot

Epigenetics and Chromatin Remodeling in Adult Cardiomyopathy

inferred← citeshttps://doi.org/10.1002/path.5992openalex-snapshot

Downregulation of HDAC9 by the ketone metabolite β‐hydroxybutyrate suppresses vascular calcification

inferred← citeshttps://doi.org/10.1002/pauz.201000363openalex-snapshot

Lesezeichen im Buch des Lebens. Epigenetik

inferred← citeshttps://doi.org/10.1002/pca.2652openalex-snapshot

UHPLC‐MS‐based HDAC Assay Applied to Bio‐guided Microfractionation of Fungal Extracts

inferred← citeshttps://doi.org/10.1002/pmic.200900464openalex-snapshot

Epigenetics to proteomics: From yeast to brain

inferred← citeshttps://doi.org/10.1002/pmic.201200001openalex-snapshot

The acetylproteome of Gram‐positive model bacterium Bacillus subtilis

inferred← citeshttps://doi.org/10.1002/pmic.201400131openalex-snapshot

How the proteome packages the genome for cardiovascular development

inferred← citeshttps://doi.org/10.1002/pmic.202300045openalex-snapshot

Functions of lysine 2‐hydroxyisobutyrylation and future perspectives on plants

inferred← citeshttps://doi.org/10.1002/poc.4268openalex-snapshot

Factors governing the affinity and selectivity of histone deacetylase inhibitors for the HDAC8 enzyme active site: Implications for anticancer therapy

inferred← citeshttps://doi.org/10.1002/prca.201400058openalex-snapshot

Inhibition of histone deacetylase 4 increases cytotoxicity of docetaxel in gastric cancer cells

inferred← citeshttps://doi.org/10.1002/pro.4512openalex-snapshot

Phage‐assisted , active site‐directed ligand evolution of a potent and selective histone deacetylase 8 inhibitor

inferred← citeshttps://doi.org/10.1002/prp2.416openalex-snapshot

Potential role for histone deacetylation in chronic diazepam‐induced downregulation of α1‐ GABAA receptor subunit expression

inferred← citeshttps://doi.org/10.1002/prp2.70057openalex-snapshot

HDAC4 /5 Inhibitor, LMK ‐235 Improves Animal Voluntary Movement in MPTP ‐Induced Parkinson's Disease Model

inferred← citeshttps://doi.org/10.1002/psc.2875openalex-snapshot

Probing the structure–activity relationship of endogenous histone deacetylase complexes with immobilized peptide‐inhibitors

inferred← citeshttps://doi.org/10.1002/psc.3462openalex-snapshot

Synthesis of Nε‐acetyl‐L‐homolysine by the Lossen rearrangement and its application for probing deacetylases and binding modules of acetyl‐lysine

inferred← citeshttps://doi.org/10.1002/ptr.7059openalex-snapshot

Epigenetic targeting of cancer stem cells by polyphenols (cancer stem cells targeting)

inferred← citeshttps://doi.org/10.1002/ptr.8524openalex-snapshot

Harnessing Dietary Phytochemicals to Modulate Signaling Pathways in Cancer Chemoprevention—A Review

inferred← citeshttps://doi.org/10.1002/smtd.202502355openalex-snapshot

Label‐Free Fluorescence‐Based Enzyme Assays Using Supramolecular Host‐Guest Approaches

inferred← citeshttps://doi.org/10.1002/stem.1544openalex-snapshot

Histone Deacetylase Inhibition with Valproic Acid Downregulates Osteocalcin Gene Expression in Human Dental Pulp Stem Cells and Osteoblasts: Evidence for HDAC2 Involvement

inferred← citeshttps://doi.org/10.1002/stem.2471openalex-snapshot

The Epigenetic Regulator HDAC1 Modulates Transcription of a Core Cardiogenic Program in Human Cardiac Mesenchymal Stromal Cells Through a p53-Dependent Mechanism

inferred← citeshttps://doi.org/10.1002/stem.3021openalex-snapshot

Epigenetic Priming of Human Pluripotent Stem Cell-Derived Cardiac Progenitor Cells Accelerates Cardiomyocyte Maturation

inferred← citeshttps://doi.org/10.1002/tox.23516openalex-snapshot

MicroRNA ‐455‐3p functions as a tumor suppressor by targeting HDAC2 to regulate cell cycle in hepatocellular carcinoma

inferred← citeshttps://doi.org/10.1002/wjo2.186openalex-snapshot

Sirt5 affects the metabolic remodeling of eosinophils by negatively regulating the level of succinylation modification of Pkm2 in eosinophilic chronic rhinosinusitis

inferred← citeshttps://doi.org/10.1007/164_2018_101openalex-snapshot

Transcriptional Regulators as Targets for Alcohol Pharmacotherapies

inferred← citeshttps://doi.org/10.1007/164_2020_422openalex-snapshot

The Epigenome in Atherosclerosis

inferred← citeshttps://doi.org/10.1007/16833_2023_128openalex-snapshot

Triple-Negative Breast Cancer Therapy: Recent Advances, Challenges, and Future Perspective

inferred← citeshttps://doi.org/10.1007/174_2022_299openalex-snapshot

Epigenetic Events in Lung Cancer

inferred← citeshttps://doi.org/10.1007/7355_2010_10openalex-snapshot

The Role of Histone Deacetylases in Neurodegenerative Diseases and Small-Molecule Inhibitors as a Potential Therapeutic Approach

inferred← citeshttps://doi.org/10.1007/82_2009_7openalex-snapshot

Varicella-Zoster Virus Open Reading Frame 66 Protein Kinase and Its Relationship to Alphaherpesvirus US3 Kinases

inferred← citeshttps://doi.org/10.1007/8415_2011_109openalex-snapshot

Bone Cell Mechanoresponsiveness

inferred← citeshttps://doi.org/10.1007/978-0-387-78991-0_11openalex-snapshot

Current Research and Future Direction

inferred← citeshttps://doi.org/10.1007/978-0-85729-209-4_12openalex-snapshot

Genetics of Carotid Disease

inferred← citeshttps://doi.org/10.1007/978-0-85729-458-6_2openalex-snapshot

Epigenetics and Brain Cancer

inferred← citeshttps://doi.org/10.1007/978-1-0716-2788-4_30openalex-snapshot

Expression and Crystallization of HDAC6 Tandem Catalytic Domains

inferred← citeshttps://doi.org/10.1007/978-1-0716-2788-4_32openalex-snapshot

Immunoprecipitation of HDAC6 and Interacting Proteins

inferred← citeshttps://doi.org/10.1007/978-1-4419-1160-5_5openalex-snapshot

Zebrafish as a Biological System for Identifying and Validating Therapeutic Targets and Compounds

inferred← citeshttps://doi.org/10.1007/978-1-4419-6382-6_15openalex-snapshot

Regulation of Chromatin Structure and Transcription Via Histone Modifications

inferred← citeshttps://doi.org/10.1007/978-1-4614-0631-0_15openalex-snapshot

HDAC Inhibition Prevents Rd1 Mouse Photoreceptor Degeneration

inferred← citeshttps://doi.org/10.1007/978-1-4614-0730-0_11openalex-snapshot

Protein Kinase D Signaling in Cancer

inferred← citeshttps://doi.org/10.1007/978-1-4939-0706-9_2openalex-snapshot

Role of Epigenetics in Neural Differentiation: Implications for Health and Disease

inferred← citeshttps://doi.org/10.1007/978-1-4939-0706-9_3openalex-snapshot

An Overview of Epigenetic Mechanisms in Health and Disease

inferred← citeshttps://doi.org/10.1007/978-1-4939-1227-8_5openalex-snapshot

Cardiac Energy Metabolism in Heart Failure Associated with Obesity and Diabetes

inferred← citeshttps://doi.org/10.1007/978-1-4939-1755-6_13openalex-snapshot

Assessing GPCR and G Protein Signaling to the Nucleus in Live Cells Using Fluorescent Biosensors

inferred← citeshttps://doi.org/10.1007/978-1-4939-3667-0_1openalex-snapshot

A Sensitive and Flexible Assay for Determining Histone Deacetylase 1 (HDAC1) Activity

inferred← citeshttps://doi.org/10.1007/978-1-4939-3667-0_19openalex-snapshot

HDAC Inhibitors

inferred← citeshttps://doi.org/10.1007/978-1-4939-3667-0_4openalex-snapshot

Molecular and Functional Characterization of Histone Deacetylase 4 (HDAC4)

inferred← citeshttps://doi.org/10.1007/978-1-4939-3667-0_7openalex-snapshot

Analysis of Histone Deacetylase 7 (HDAC7) Alternative Splicing and Its Role in Embryonic Stem Cell Differentiation Toward Smooth Muscle Lineage

inferred← citeshttps://doi.org/10.1007/978-1-4939-6527-4_1openalex-snapshot

Detection of Autophagy Induction After HDAC Inhibitor Treatment in Leukemic Cells

inferred← citeshttps://doi.org/10.1007/978-1-4939-6527-4_13openalex-snapshot

Generation of Tissue-Specific Mouse Models to Analyze HDAC Functions

inferred← citeshttps://doi.org/10.1007/978-1-4939-8751-1_7openalex-snapshot

Effects of Dietary Nutrients on Epigenetic Changes in Cancer

inferred← citeshttps://doi.org/10.1007/978-1-4939-9434-2_17openalex-snapshot

Functional Analysis of HDACs in Tumorigenesis

inferred← citeshttps://doi.org/10.1007/978-1-61779-034-8_31openalex-snapshot

Use of Polyamine Derivatives as Selective Histone Deacetylase Inhibitors

inferred← citeshttps://doi.org/10.1007/978-1-62703-386-2_7openalex-snapshot

Systems Proteomics of Healthy and Diseased Chromatin

inferred← citeshttps://doi.org/10.1007/978-1-84882-644-1_9openalex-snapshot

Epigenetics and Type 2 Diabetes

inferred← citeshttps://doi.org/10.1007/978-1-84996-480-7openalex-snapshot

Heart Failure in Congenital Heart Disease: : From Fetus to Adult

inferred← citeshttps://doi.org/10.1007/978-3-030-21573-6_10061-1openalex-snapshot

Epigenetics

inferred← citeshttps://doi.org/10.1007/978-3-030-36871-5_27openalex-snapshot

TH Treatment in Patients with Cardiac Disorders: General Aspects and Rationale

inferred← citeshttps://doi.org/10.1007/978-3-030-43085-6_4openalex-snapshot

Targeting the Cancer Epigenome with Histone Deacetylase Inhibitors in Osteosarcoma

inferred← citeshttps://doi.org/10.1007/978-3-030-53868-2_5openalex-snapshot

DAMP-Promoted Efferent Innate Immune Responses in Human Diseases: Inflammation

inferred← citeshttps://doi.org/10.1007/978-3-030-57401-7_10061openalex-snapshot

Epigenetics

inferred← citeshttps://doi.org/10.1007/978-3-030-63164-2_9openalex-snapshot

Mechanical Regulation of Epigenetic Modifications in Vascular Biology and Pathobiology

inferred← citeshttps://doi.org/10.1007/978-3-030-80962-1_103-1openalex-snapshot

Tumor Metabolism: Challenges and Future Perspectives

inferred← citeshttps://doi.org/10.1007/978-3-030-92499-7_7openalex-snapshot

Epigenetic Control of Diatom Genomes: An Overview from In Silico Characterization to Functional Studies

inferred← citeshttps://doi.org/10.1007/978-3-031-04998-9_3openalex-snapshot

Polypharmacology in Clinical Applications—Anticancer Polypharmacology

inferred← citeshttps://doi.org/10.1007/978-3-031-13771-6_7openalex-snapshot

Epigenetics and the Extreme Stress Response

inferred← citeshttps://doi.org/10.1007/978-3-031-32035-4_132-1openalex-snapshot

Obsessive-Compulsive Disorder and the Histone Deacetylase (HDAC) Genes

inferred← citeshttps://doi.org/10.1007/978-3-031-33871-7_2openalex-snapshot

In Silico Discovery of Class IIb HDAC Inhibitors: The State of Art

inferred← citeshttps://doi.org/10.1007/978-3-031-40086-5_15openalex-snapshot

Human Endogenous Retroviruses in Diseases

inferred← citeshttps://doi.org/10.1007/978-3-031-41777-1_14openalex-snapshot

Genetics of Carotid Atherosclerosis

inferred← citeshttps://doi.org/10.1007/978-3-031-44087-8_18openalex-snapshot

Epigenetics

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