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TIP30 regulates lipid metabolism in hepatocellular carcinoma by regulating SREBP1 through the Akt/mTOR signaling pathway
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1002/hep.21213openalex-snapshot
TIP30 inhibits growth of HCC cell lines and inhibits HCC xenografts in mice in combination with 5-FU
inferredcites →https://doi.org/10.1002/hep.22280openalex-snapshot
Thirty‐kilodalton Tat‐interacting protein suppresses tumor metastasis by inhibition of osteopontin transcription in human hepatocellular carcinoma†
inferredcites →https://doi.org/10.1002/hep.26323openalex-snapshot
The mTOR Pathway in Hepatic Malignancies
inferredcites →https://doi.org/10.1002/hep.28368openalex-snapshot
Clinical patterns of hepatocellular carcinoma in nonalcoholic fatty liver disease: A multicenter prospective study
inferredcites →https://doi.org/10.1002/hep.29018openalex-snapshot
Inhibition of the sterol regulatory element‐binding protein pathway suppresses hepatocellular carcinoma by repressing inflammation in mice
inferredcites →https://doi.org/10.1002/ijc.23638openalex-snapshot
TIP30 is associated with progression and metastasis of prostate cancer
inferredcites →https://doi.org/10.1002/ijc.28471openalex-snapshot
Decreased TIP30 expression predicts poor prognosis in pancreatic cancer patients
inferredcites →https://doi.org/10.1002/pmic.201400202openalex-snapshot
Proteomic analysis of livers from fat‐fed mice deficient in either PKCδ or PKCε identifies Htatip2 as a regulator of lipid metabolism
inferredcites →https://doi.org/10.1007/s11864-016-0415-3openalex-snapshot
Advanced Hepatocellular Cancer: the Current State of Future Research
inferredcites →https://doi.org/10.1016/j.cmet.2008.07.007openalex-snapshot
SREBP Activity Is Regulated by mTORC1 and Contributes to Akt-Dependent Cell Growth
inferredcites →https://doi.org/10.1016/j.cmet.2013.05.017openalex-snapshot
Cellular Fatty Acid Metabolism and Cancer
inferredcites →https://doi.org/10.1016/j.humpath.2006.08.005openalex-snapshot
TIP30/CC3 expression in breast carcinoma: relation to metastasis, clinicopathologic parameters, and P53 expression
inferredcites →https://doi.org/10.1016/j.jhep.2008.07.036openalex-snapshot
Activation of lipogenic pathway correlates with cell proliferation and poor prognosis in hepatocellular carcinoma
inferredcites →https://doi.org/10.1016/j.jhep.2015.07.039openalex-snapshot
CD147 reprograms fatty acid metabolism in hepatocellular carcinoma cells through Akt/mTOR/SREBP1c and P38/PPARα pathways
inferredcites →https://doi.org/10.1016/j.jhep.2015.10.004openalex-snapshot
Inactivation of fatty acid synthase impairs hepatocarcinogenesis driven by AKT in mice and humans
inferredcites →https://doi.org/10.1016/j.jss.2013.07.001openalex-snapshot
Stearoyl-CoA desaturase plays an important role in proliferation and chemoresistance in human hepatocellular carcinoma
inferredcites →https://doi.org/10.1038/cddis.2014.424openalex-snapshot
Contribution of TIP30 to chemoresistance in laryngeal carcinoma
inferredcites →https://doi.org/10.1038/nrc.2016.89openalex-snapshot
The multifaceted roles of fatty acid synthesis in cancer
inferredcites →https://doi.org/10.1038/nrc2222openalex-snapshot
Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis
inferredcites →https://doi.org/10.1038/nrclinonc.2016.60openalex-snapshot
Cancer metabolism: a therapeutic perspective
inferredcites →https://doi.org/10.1038/nrclinonc.2017.1openalex-snapshot
Erratum: Cancer metabolism: a therapeutic perspective
inferredcites →https://doi.org/10.1038/onc.2012.253openalex-snapshot
TIP30 loss enhances cytoplasmic and nuclear EGFR signaling and promotes lung adenocarcinogenesis in mice
inferredcites →https://doi.org/10.1038/onc.2013.405openalex-snapshot
microRNA-10b enhances pancreatic cancer cell invasion by suppressing TIP30 expression and promoting EGF and TGF-β actions
inferredcites →https://doi.org/10.1038/onc.2014.73openalex-snapshot
Decreased TIP30 promotes Snail-mediated epithelial–mesenchymal transition and tumor-initiating properties in hepatocellular carcinoma
inferredcites →https://doi.org/10.1038/sj.onc.1201059openalex-snapshot
A link between metastasis and resistance to apoptosis of variant small cell lung carcinoma
inferredcites →https://doi.org/10.1038/sj.onc.1204075openalex-snapshot
Metastasis suppressor CC3 inhibits angiogenic properties of tumor cells in vitro
inferredcites →https://doi.org/10.1038/srep20484openalex-snapshot
Co-activation of AKT and c-Met triggers rapid hepatocellular carcinoma development via the mTORC1/FASN pathway in mice
inferredcites →https://doi.org/10.1042/bst0301091openalex-snapshot
Sterol regulatory element-binding proteins: transcriptional activators of lipid synthesis
inferredcites →https://doi.org/10.1053/j.gastro.2010.12.006openalex-snapshot
Increased Lipogenesis, Induced by AKT-mTORC1-RPS6 Signaling, Promotes Development of Human Hepatocellular Carcinoma
inferredcites →https://doi.org/10.1074/jbc.m110.207720openalex-snapshot
A Novel TIP30 Protein Complex Regulates EGF Receptor Signaling and Endocytic Degradation
inferredcites →https://doi.org/10.1074/jbc.m111.277699openalex-snapshot
Extracellular Membrane-proximal Domain of HAb18G/CD147 Binds to Metal Ion-dependent Adhesion Site (MIDAS) Motif of Integrin β1 to Modulate Malignant Properties of Hepatoma Cells
inferredcites →https://doi.org/10.1074/jbc.m113.497685openalex-snapshot
CD147, CD44, and the Epidermal Growth Factor Receptor (EGFR) Signaling Pathway Cooperate to Regulate Breast Epithelial Cell Invasiveness
inferredcites →https://doi.org/10.1093/bioinformatics/btp101openalex-snapshot
ClueGO: a Cytoscape plug-in to decipher functionally grouped gene ontology and pathway annotation networks
inferredcites →https://doi.org/10.1097/mol.0b013e328352dd03openalex-snapshot
Connecting mTORC1 signaling to SREBP-1 activation
inferredcites →https://doi.org/10.1111/liv.13183openalex-snapshot
Both de novo synthetized and exogenous fatty acids support the growth of hepatocellular carcinoma cells
inferredcites →https://doi.org/10.1158/0008-5472.can-08-0432openalex-snapshot
TIP30 Induces Apoptosis under Oxidative Stress through Stabilization of p53 Messenger RNA in Human Hepatocellular Carcinoma
inferredcites →https://doi.org/10.1158/0008-5472.can-10-3057openalex-snapshot
Tip30 Deletion in MMTV-Neu Mice Leads to Enhanced EGFR Signaling and Development of Estrogen Receptor–Positive and Progesterone Receptor–Negative Mammary Tumors
inferredcites →https://doi.org/10.1158/1078-0432.ccr-08-0409openalex-snapshot
Methylation of Tip30 Promoter Is Associated with Poor Prognosis in Human Hepatocellular Carcinoma
inferredcites →https://doi.org/10.1158/1078-0432.ccr-13-0621openalex-snapshot
HAb18G/CD147 Promotes pSTAT3-Mediated Pancreatic Cancer Development via CD44s
inferredcites →https://doi.org/10.1172/jci0215593openalex-snapshot
SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver
inferredcites →https://doi.org/10.1172/jci15593openalex-snapshot
SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver
inferredcites →https://doi.org/10.1186/2047-783x-18-18openalex-snapshot
High serum HTATIP2/TIP30 level in serous ovarian cancer as prognostic or diagnostic marker
inferredcites →https://doi.org/10.1245/s10434-013-3070-yopenalex-snapshot
Prediction of Disease-free Survival in Hepatocellular Carcinoma by Gene Expression Profiling
inferredcites →https://doi.org/10.18632/oncotarget.2940openalex-snapshot
TGF-β1 induces epigenetic silence of TIP30 to promote tumor metastasis in esophageal carcinoma
inferredcites →https://doi.org/10.2174/13816128113199990486openalex-snapshot
Targeting SREBP-1-driven Lipid Metabolism to Treat Cancer
inferredcites →https://doi.org/10.2353/ajpath.2009.080846openalex-snapshot
Decreased TIP30 Expression Promotes Tumor Metastasis in Lung Cancer
inferredcites →https://doi.org/10.3390/ijms15057124openalex-snapshot
SREBP-1 Has a Prognostic Role and Contributes to Invasion and Metastasis in Human Hepatocellular Carcinoma
inferredcites →https://doi.org/10.3727/096504015x14424348426116openalex-snapshot
TIP30: A Novel Tumor-Suppressor Gene
inferredcites →https://doi.org/10.3748/wjg.v11.i2.221openalex-snapshot
TIP30 regulates apoptosis-related genes in its apoptotic signal transduction pathway
inferredcites →https://doi.org/10.3892/mmr.2015.4619openalex-snapshot
Overexpression of TIP30 inhibits the growth and invasion of glioma cells
inferredcites →https://doi.org/10.4161/cc.9.24.14230openalex-snapshot
CC3/TIP30 regulates metabolic adaptation of tumor cells to glucose limitation
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
inferred← citeshttps://doi.org/10.2139/ssrn.4665445openalex-extracted
Linggui Zhugan Decoction Delayed the Progression of NAFLD-HCC by Regulating Fatty Acid Metabolism Through AKT/mTOR/SREBP-1/SCD-1 Signaling Pathway
inferred← citeshttps://doi.org/10.1002/2211-5463.70115openalex-snapshot
Berberine–cinnamic acid co‐crystal effect in ameliorating hyperlipidemia might be regulated through the PI3K / AKT / mTOR / SREBP ‐1 signaling pathway
inferred← citeshttps://doi.org/10.1002/ddr.70014openalex-snapshot
The Role of Fatty Acid Metabolism, the Related Potential Biomarkers, and Targeted Therapeutic Strategies in Gastrointestinal Cancers
inferred← citeshttps://doi.org/10.1002/lci2.68openalex-snapshot
The regulation and functions of ACSL3 and ACSL4 in the liver and hepatocellular carcinoma
inferred← citeshttps://doi.org/10.1007/s10555-023-10156-5openalex-snapshot
Regulation and targeting of SREBP-1 in hepatocellular carcinoma
inferred← citeshttps://doi.org/10.1007/s12192-023-01357-6openalex-snapshot
ORP5 promotes migration and invasion of cervical cancer cells by inhibiting endoplasmic reticulum stress
inferred← citeshttps://doi.org/10.1016/j.chemosphere.2021.132419openalex-snapshot
Toxicity pathways of lipid metabolic disorders induced by typical replacement flame retardants via data-driven analysis, in silico and in vitro approaches
inferred← citeshttps://doi.org/10.1016/j.fct.2022.113450openalex-snapshot
Apoptosis induction in human prostate cancer cells related to the fatty acid metabolism by wogonin-mediated regulation of the AKT-SREBP1-FASN signaling network
inferred← citeshttps://doi.org/10.1016/j.gendis.2023.04.022openalex-snapshot
The roles and mechanisms of SREBP1 in cancer development and drug response
inferred← citeshttps://doi.org/10.1016/j.jpba.2024.116507openalex-snapshot
Integrated network pharmacology, metabolomics and molecular docking analysis to reveal the mechanisms of quercetin in the treatment of hyperlipidemia
inferred← citeshttps://doi.org/10.1016/j.lfs.2020.118415openalex-snapshot
Niacin inhibits the synthesis of milk fat in BMECs through the GPR109A-mediated downstream signalling pathway
inferred← citeshttps://doi.org/10.1016/j.livres.2021.06.001openalex-snapshot
Novel oncogenes and tumor suppressor genes in hepatocellular carcinoma
inferred← citeshttps://doi.org/10.1016/j.semcancer.2019.06.002openalex-snapshot
Akt in cancer: Mediator and more
inferred← citeshttps://doi.org/10.1021/acs.jafc.5c17181openalex-snapshot
Protective Effects of Astaxanthin on PFOS-Induced Liver Injury via Fatty Acid and Cholesterol Metabolic Pathways
inferred← citeshttps://doi.org/10.1038/s41388-022-02477-6openalex-snapshot
The NQO1/p53/SREBP1 axis promotes hepatocellular carcinoma progression and metastasis by regulating Snail stability
inferred← citeshttps://doi.org/10.1038/s41419-019-1828-2openalex-snapshot
mTOR direct crosstalk with STAT5 promotes de novo lipid synthesis and induces hepatocellular carcinoma
inferred← citeshttps://doi.org/10.1038/s41419-021-03762-0openalex-snapshot
Fatostatin reverses progesterone resistance by inhibiting the SREBP1-NF-κB pathway in endometrial carcinoma
inferred← citeshttps://doi.org/10.1096/fj.202602519ropenalex-snapshot
Impaired mTOR / SREBP1 ‐Mediated Lipogenesis as a Mechanism of Hepatic Glycogen Accumulation in a Carnivorous Fish Model, Largemouth Bass ( Micropterus salmoides )
inferred← citeshttps://doi.org/10.1111/cas.13768openalex-snapshot
Human immunodeficiency virus Tat‐ TIP 30 interaction promotes metastasis by enhancing the nuclear translocation of Snail in lung cancer cell lines
inferred← citeshttps://doi.org/10.1142/s0192415x21500683openalex-snapshot
The Role of Ophiopogonin D in Atherosclerosis: Impact on Lipid Metabolism and Gut Microbiota
inferred← citeshttps://doi.org/10.1177/0963689718780304openalex-snapshot
Preconditioning Enhances the Therapeutic Effects of Mesenchymal Stem Cells on Colitis Through PGE2-Mediated T-Cell Modulation
inferred← citeshttps://doi.org/10.1186/s12864-019-5889-5openalex-snapshot
About the existence of common determinants of gene expression in the porcine liver and skeletal muscle
inferred← citeshttps://doi.org/10.1186/s12885-019-5904-xopenalex-snapshot
SREBP1 promotes the invasion of colorectal cancer accompanied upregulation of MMP7 expression and NF-κB pathway activation
inferred← citeshttps://doi.org/10.1186/s12885-022-10354-4openalex-snapshot
MYBL2 regulates de novo purine synthesis by transcriptionally activating IMPDH1 in hepatocellular carcinoma cells
inferred← citeshttps://doi.org/10.1186/s12935-019-0804-3openalex-snapshot
Systems biology based meth-miRNA–mRNA regulatory network identifies metabolic imbalance and hyperactive cell cycle signaling involved in hepatocellular carcinoma onset and progression
inferred← citeshttps://doi.org/10.1186/s13046-019-1219-7openalex-snapshot
The hypoxia conditioned mesenchymal stem cells promote hepatocellular carcinoma progression through YAP mediated lipogenesis reprogramming
inferred← citeshttps://doi.org/10.1186/s40880-018-0301-4openalex-snapshot
Lipid metabolism reprogramming and its potential targets in cancer
inferred← citeshttps://doi.org/10.1210/endocr/bqac040openalex-snapshot
Al-MPS Obstructs EMT in Breast Cancer by Inhibiting Lipid Metabolism via miR-215-5p/SREBP1
inferred← citeshttps://doi.org/10.12677/acm.2021.116394openalex-snapshot
Research Status and Prospect of Metabolic Abnormalities in Hepatocellular Carcinoma
inferred← citeshttps://doi.org/10.14218/jcth.2023.00397openalex-snapshot
Role of Fibrinogen-like Protein 1 in Tumor Recurrence Following Hepatectomy
inferred← citeshttps://doi.org/10.14715/cmb/2018.64.5.12openalex-snapshot
RASSF7 promotes cell proliferation through activating MEK1/2-ERK1/2 signaling pathway in hepatocellular carcinoma
inferred← citeshttps://doi.org/10.21203/rs.3.rs-1597599/v1openalex-snapshot
MYBL2 regulates de novo purine synthesis by transcriptionally activating IMPDH1 in hepatocellular carcinoma cells
inferred← citeshttps://doi.org/10.3168/jds.2021-21287openalex-snapshot
Activated autophagy-lysosomal pathway in dairy cows with hyperketonemia is associated with lipolysis of adipose tissues
inferred← citeshttps://doi.org/10.3389/fcvm.2022.892335openalex-snapshot
Etiology and Management of Dyslipidemia in Patients With Cancer
inferred← citeshttps://doi.org/10.3389/fimmu.2023.1161960openalex-snapshot
Monoacylglycerol lipase regulates macrophage polarization and cancer progression in uveal melanoma and pan-cancer
inferred← citeshttps://doi.org/10.3389/fonc.2019.00290openalex-snapshot
PGC1β Regulates Breast Tumor Growth and Metastasis by SREBP1-Mediated HKDC1 Expression
inferred← citeshttps://doi.org/10.3389/fonc.2019.01000openalex-snapshot
mTOR/HDAC1 Crosstalk Mediated Suppression of ADH1A and ALDH2 Links Alcohol Metabolism to Hepatocellular Carcinoma Onset and Progression in silico
inferred← citeshttps://doi.org/10.3389/fonc.2019.01359openalex-snapshot
Ping-Pong—Tumor and Host in Pancreatic Cancer Progression
inferred← citeshttps://doi.org/10.3389/fphar.2022.1019312openalex-snapshot
Short-chain L-3-hydroxyacyl-CoA dehydrogenase: A novel vital oncogene or tumor suppressor gene in cancers
inferred← citeshttps://doi.org/10.3389/fphar.2024.1495343openalex-snapshot
Efficacy and safety of TACE combined with traditional Chinese medicine versus TACE alone in hepatocellular carcinoma: bayesian network meta-analysis and pharmacological mechanisms study
inferred← citeshttps://doi.org/10.3390/cancers12113469openalex-snapshot
Lipid Regulatory Proteins as Potential Therapeutic Targets for Ovarian Cancer in Obese Women
inferred← citeshttps://doi.org/10.3390/cancers15133451openalex-snapshot
Co-Targeting FASN and mTOR Suppresses Uveal Melanoma Growth
inferred← citeshttps://doi.org/10.3390/ijms24032652openalex-snapshot
The Role of PI3K/AKT/mTOR Signaling in Hepatocellular Carcinoma Metabolism
inferred← citeshttps://doi.org/10.3390/jcm8010083openalex-snapshot
Low TIP30 Protein Expression is Associated with a High Risk of Metastasis and Poor Prognosis for Non-Small-Cell Lung Cancer
inferred← citeshttps://doi.org/10.3390/molecules30153103openalex-snapshot
Research Progress and Prospects of Flavonoids in the Treatment of Hyperlipidemia: A Narrative Review
inferred← citeshttps://doi.org/10.5772/intechopen.77400openalex-snapshot
Novel Mechanism of Nonalcoholic Lipid Accumulation Promoting Malignant Transformation of Hepatocytes
inferred← citeshttps://doi.org/10.6084/m9.figshare.22604791openalex-snapshot
Additional file 1 of MYBL2 regulates de novo purine synthesis by transcriptionally activating IMPDH1 in hepatocellular carcinoma cells
inferred← citeshttps://doi.org/10.6084/m9.figshare.22604794openalex-snapshot
Additional file 2 of MYBL2 regulates de novo purine synthesis by transcriptionally activating IMPDH1 in hepatocellular carcinoma cells
inferred← citeshttps://doi.org/10.6084/m9.figshare.22604797openalex-snapshot
Additional file 3 of MYBL2 regulates de novo purine synthesis by transcriptionally activating IMPDH1 in hepatocellular carcinoma cells
inferred← citeshttps://doi.org/10.6084/m9.figshare.22604803openalex-snapshot
Additional file 4 of MYBL2 regulates de novo purine synthesis by transcriptionally activating IMPDH1 in hepatocellular carcinoma cells
inferred← citeshttps://doi.org/10.6084/m9.figshare.22604806openalex-snapshot
Additional file 5 of MYBL2 regulates de novo purine synthesis by transcriptionally activating IMPDH1 in hepatocellular carcinoma cells
inferred← citeshttps://doi.org/10.7150/jca.26578openalex-snapshot
Lycopene upregulates ZO-1 and downregulates claudin-1 through autophagy inhibition in the human cutaneous squamous cell carcinoma cell line COLO-16
inferred← citeshttps://doi.org/10.7554/elife.54186openalex-snapshot
Epigenetic inheritance of circadian period in clonal cells
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