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Expression of Concern: Carrageenan‐induced mouse paw oedema is biphasic, age‐weight dependent and displays differential nitric oxide cyclooxygenase‐2 expression

https://doi.org/10.1038/sj.bjp.0705650

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/path.1711040103openalex-snapshot

Studies of the mediators of the acute inflammatory response induced in rats in different sites by carrageenan and turpentine

inferredcites →https://doi.org/10.1002/path.1711050403openalex-snapshot

A histopathological and pharmacological analysis of the mode of action of non‐steroidal anti‐inflammatory drugs

inferredcites →https://doi.org/10.1006/abio.1993.1449openalex-snapshot

A Fluorometric Assay for the Measurement of Nitrite in Biological Samples

inferredcites →https://doi.org/10.1007/bf01966499openalex-snapshot

Effect of selected antiinflammatory agents and other drugs on zymosan, arachidonic acid, PAF and carrageenan induced paw edema in the mouse

inferredcites →https://doi.org/10.1007/s000110050494openalex-snapshot

Cyclooxygenase-2-dependent generation of 8-epiprostaglandin F2α by lipopolysaccharide-activated J774 macrophages

inferredcites →https://doi.org/10.1016/0024-3205(69)90021-6openalex-snapshot

Carrageenan paw edema in the mouse

inferredcites →https://doi.org/10.1016/0024-3205(69)90215-xopenalex-snapshot

The relationship between urinary taurine excretion and the intake of protein-rich foods

inferredcites →https://doi.org/10.1016/s0006-8993(01)02733-0openalex-snapshot

Peripheral nitric oxide in carrageenan-induced inflammation

inferredcites →https://doi.org/10.1016/s0014-2999(03)01664-9openalex-snapshot

Anti-inflammatory activity of erycristagallin, a pterocarpene from Erythrina mildbraedii

inferredcites →https://doi.org/10.1016/s0306-4522(02)00273-7openalex-snapshot

Decreased inflammatory pain due to reduced carrageenan-induced inflammation in mice lacking adenosine A3 receptors

inferredcites →https://doi.org/10.1038/sj.bjp.0701735openalex-snapshot

A comparison of the effects of L ‐NAME, 7‐NI and L ‐NIL on carrageenan‐induced hindpaw oedema and NOS activity

inferredcites →https://doi.org/10.1038/sj.bjp.0702866openalex-snapshot

Distribution and regulation of cyclooxygenase‐2 in carrageenan‐induced inflammation

inferredcites →https://doi.org/10.1038/sj.bjp.0703549openalex-snapshot

Geldanamycin, an inhibitor of heat shock protein 90 (Hsp90) mediated signal transduction has anti‐inflammatory effects and interacts with glucocorticoid receptor in vivo

inferredcites →https://doi.org/10.1042/bj2980249openalex-snapshot

Nitric oxide synthases in mammals

inferredcites →https://doi.org/10.1111/1523-1747.ep12506462openalex-snapshot

Measurement of Cutaneous Inflammation: Estimation of Neutrophil Content with an Enzyme Marker

inferredcites →https://doi.org/10.1111/j.1365-2362.1991.tb01383.xopenalex-snapshot

Endogenous nitric oxide: physiology, pathology and clinical relevance

inferredcites →https://doi.org/10.1111/j.1476-5381.1973.tb08225.xopenalex-snapshot

Pharmacological analysis of the acute inflammatory process induced in the rat's paw by local injection of carrageenin and by heating

inferredcites →https://doi.org/10.1111/j.1476-5381.1996.tb15475.xopenalex-snapshot

Nitric oxide: a key mediator in the early and late phase of carrageenan‐induced rat paw inflammation

inferredcites →https://doi.org/10.1111/j.2042-7158.1972.tb08940.xopenalex-snapshot

Biological properties of carrageenan

inferredcites →https://doi.org/10.1248/bpb1978.4.565openalex-snapshot

Anti-inflammatory testing methods: Comparative evaluation of mice and rats.

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inferred← citeshttps://doi.org/10.1016/j.ijbiomac.2016.10.020openalex-snapshot

Structural characterization of a lectin from Canavalia virosa seeds with inflammatory and cytotoxic activities

inferred← citeshttps://doi.org/10.1016/j.ijbiomac.2017.07.142openalex-snapshot

Evaluation of anti-inflammatory potential of aqueous extract and polysaccharide fraction of Thuja occidentalis Linn. in mice

inferred← citeshttps://doi.org/10.1016/j.ijbiomac.2018.02.058openalex-snapshot

Lectin obtained from the red seaweed Bryothamnion triquetrum: Secondary structure and anti-inflammatory activity in mice

inferred← citeshttps://doi.org/10.1016/j.ijbiomac.2020.05.166openalex-snapshot

Chemical structure, anti-inflammatory and antinociceptive activities of a sulfated polysaccharide from Gracilaria intermedia algae

inferred← citeshttps://doi.org/10.1016/j.ijbiomac.2020.12.203openalex-snapshot

Lectin from red algae Amansia multifida Lamouroux: Extraction, characterization and anti-inflammatory activity

inferred← citeshttps://doi.org/10.1016/j.ijbiomac.2022.12.111openalex-snapshot

Smart redox-sensitive micelles based on chitosan for dasatinib delivery in suppressing inflammatory diseases

inferred← citeshttps://doi.org/10.1016/j.ijbiomac.2023.124085openalex-snapshot

Biological activity of algal derived carrageenan: A comprehensive review in light of human health and disease

inferred← citeshttps://doi.org/10.1016/j.ijbiomac.2024.133679openalex-snapshot

Phycobiliprotein from Arthrospira maxima: Conversion to nanoparticles by high-energy ball milling, structural characterization, and evaluation of their anti-inflammatory effect

inferred← citeshttps://doi.org/10.1016/j.ijbiomac.2025.146181openalex-snapshot

Proteomic profiling and biochemical characterization of enzymatic and non-enzymatic proteins of Heterometrus bengalensis venom and their pathophysiological functions in the Swiss albino mice model

inferred← citeshttps://doi.org/10.1016/j.ijbiomac.2026.154800openalex-snapshot

Chondroitin sulfate in inflammatory joint diseases: How structural variability shapes its therapeutic effects

inferred← citeshttps://doi.org/10.1016/j.ijpharm.2012.03.055openalex-snapshot

Anti-inflammatory and analgesic activity of novel oral aspirin-loaded nanoemulsion and nano multiple emulsion formulations generated using ultrasound cavitation

inferred← citeshttps://doi.org/10.1016/j.intimp.2012.10.015openalex-snapshot

Anti-inflammatory properties of rose oxide

inferred← citeshttps://doi.org/10.1016/j.intimp.2013.08.017openalex-snapshot

Lipophilic amino alcohols reduces carrageenan-induced paw edema and anti-OVA DTH in BALB/c mice

inferred← citeshttps://doi.org/10.1016/j.intimp.2014.02.004openalex-snapshot

Ellagic acid protects against carrageenan-induced acute inflammation through inhibition of nuclear factor kappa B, inducible cyclooxygenase and proinflammatory cytokines and enhancement of interleukin-10 via an antioxidant mechanism

inferred← citeshttps://doi.org/10.1016/j.intimp.2014.03.004openalex-snapshot

Synergistic interaction between choline and aspirin against acute inflammation induced by carrageenan and lipopolysaccharide

inferred← citeshttps://doi.org/10.1016/j.intimp.2023.111059openalex-snapshot

Site-selective synthesis and pharmacological elucidation of novel semi-synthetic analogues of koenimbine as a potential anti-inflammatory agent

inferred← citeshttps://doi.org/10.1016/j.jconrel.2013.10.009openalex-snapshot

Redox-active injectable gel using thermo-responsive nanoscale polyion complex flower micelle for noninvasive treatment of local inflammation

inferred← citeshttps://doi.org/10.1016/j.jep.2008.05.002openalex-snapshot

Anti-inflammatory effects of hydroalcoholic extract and two biflavonoids from Garcinia gardneriana leaves in mouse paw oedema

inferred← citeshttps://doi.org/10.1016/j.jep.2009.06.003openalex-snapshot

Antipyretic and anti-inflammatory properties of the ethanolic extract, dichloromethane fraction and costunolide from Magnolia ovata (Magnoliaceae)

inferred← citeshttps://doi.org/10.1016/j.jep.2009.06.005openalex-snapshot

Antiinflammatory and antinociceptive activities of Blechnum occidentale L. extract

inferred← citeshttps://doi.org/10.1016/j.jep.2009.06.024openalex-snapshot

Analgesic and anti-inflammatory activities of ethanol root extract of Mahonia oiwakensis in mice

inferred← citeshttps://doi.org/10.1016/j.jep.2010.05.065openalex-snapshot

Antinociceptive and antiinflammatory activities of Adiantum latifolium Lam.: Evidence for a role of IL-1β inhibition

inferred← citeshttps://doi.org/10.1016/j.jep.2011.04.067openalex-snapshot

Chlorogenic acids from Tithonia diversifolia demonstrate better anti-inflammatory effect than indomethacin and its sesquiterpene lactones

inferred← citeshttps://doi.org/10.1016/j.jep.2012.08.033openalex-snapshot

Venom's antinociceptive property in the primitive ant Dinoponera quadriceps

inferred← citeshttps://doi.org/10.1016/j.jep.2016.02.051openalex-snapshot

Anti-inflammatory and antinociceptive activities of Croton urucurana Baillon bark

inferred← citeshttps://doi.org/10.1016/j.jep.2017.01.008openalex-snapshot

Anti-inflammatory and toxicological evaluation of essential oil from Piper glabratum leaves

inferred← citeshttps://doi.org/10.1016/j.jep.2017.02.034openalex-snapshot

Rhizoma Smilacis Glabrae inhibits pathogen-induced upper genital tract inflammation in rats through suppression of NF-κB pathway

inferred← citeshttps://doi.org/10.1016/j.jep.2017.05.014openalex-snapshot

Inhibition of proinflammatory mediators by coumaroyl lupendioic acid, a new lupane-type triterpene from Careya arborea , on inflammation-induced animal model

inferred← citeshttps://doi.org/10.1016/j.jep.2017.11.002openalex-snapshot

Comparison of two Jatropha species (Euphorbiaceae) used popularly to treat snakebites in Northeastern Brazil: Chemical profile, inhibitory activity against Bothrops erythromelas venom and antibacterial activity

inferred← citeshttps://doi.org/10.1016/j.jep.2018.09.007openalex-snapshot

Development of an effective and safe topical anti-inflammatory gel containing Jatropha gossypiifolia leaf extract: Results from a pre-clinical trial in mice

inferred← citeshttps://doi.org/10.1016/j.jep.2019.112399openalex-snapshot

Ameliorative potential of Argyreia speciosa against CCI-induced neuropathic pain in rats: Biochemical and histopathological studies

inferred← citeshttps://doi.org/10.1016/j.jep.2020.112654openalex-snapshot

Anti-inflammatory and anti-nociceptive property of Capparis tomentosa Lam. root extracts

inferred← citeshttps://doi.org/10.1016/j.jep.2020.112966openalex-snapshot

Pharmacological evaluation of analgesic, anti-inflammatory and antipyretic activities of ethanolic extract of Indigofera argentea Burm. f.

inferred← citeshttps://doi.org/10.1016/j.jep.2020.113229openalex-snapshot

Mass spectrometry characterization of Commiphora leptophloeos leaf extract and preclinical evaluation of toxicity and anti-inflammatory potential effect

inferred← citeshttps://doi.org/10.1016/j.jep.2021.113868openalex-snapshot

Cannabis roots: Pharmacological and toxicological studies in mice

inferred← citeshttps://doi.org/10.1016/j.jep.2021.114179openalex-snapshot

Systematic review of Ethiopian medicinal plants used for their anti-inflammatory and wound healing activities

inferred← citeshttps://doi.org/10.1016/j.jep.2021.114182openalex-snapshot

Central and peripheral pain intervention by Ophiorrhiza rugosa leaves: Potential underlying mechanisms and insight into the role of pain modulators

inferred← citeshttps://doi.org/10.1016/j.jep.2021.114628openalex-snapshot

Ethanolic extract of Pyrus pashia buch ham ex. D. Don (Kainth): A bioaccessible source of polyphenols with anti-inflammatory activity in vitro and in vivo

inferred← citeshttps://doi.org/10.1016/j.jep.2022.115881openalex-snapshot

Chemical composition and effects of ethanolic extract and gel of Cochlospermum regium (Schrank) Pilg. Leaves on inflammation, pain, and wounds

inferred← citeshttps://doi.org/10.1016/j.jep.2022.116017openalex-snapshot

Chemical characterization, anti-nociceptive and anti-inflammatory activities of Plukenetia conophora seed oil in experimental rodent models

inferred← citeshttps://doi.org/10.1016/j.jep.2022.116018openalex-snapshot

Antinociceptive and anti-inflammatory properties of aqueous extract obtained from Serjania marginata Casar leaves

inferred← citeshttps://doi.org/10.1016/j.jep.2023.116473openalex-snapshot

Chemical characterization, antinociceptive and anti-inflammatory effect of Lippia lacunosa, a species used by the Bandeirantes

inferred← citeshttps://doi.org/10.1016/j.jep.2023.117223openalex-snapshot

In vitro and in vivo anti-inflammatory and antiophidic effects of the extract and fraction of Eugenia uniflora

inferred← citeshttps://doi.org/10.1016/j.jep.2024.118104openalex-snapshot

Triterpenes G-A and G-E from Galphimia glauca with anti-inflammatory and anti-arthritic activity in mice

inferred← citeshttps://doi.org/10.1016/j.jep.2024.118188openalex-snapshot

Nanoemulsion containing Jatropha gossypiifolia leaf extract reduces dermonecrosis induced by Bothrops erythromelas venom and accelerates wound closure

inferred← citeshttps://doi.org/10.1016/j.jep.2024.118619openalex-snapshot

Anti-inflammatory and antiophidic effects of extract of Hymenaea eriogyne benth and structure-activity relationship prediction of the major markers in silico

inferred← citeshttps://doi.org/10.1016/j.jep.2025.120203openalex-snapshot

Traditional knowledge and pharmacological evidence of pequi (Caryocar brasiliense) root bark for pain and inflammation

inferred← citeshttps://doi.org/10.1016/j.jep.2026.121882openalex-snapshot

Ethnopharmacological validation of the anti-inflammatory, analgesic and antioxidant activities of Myrtus communis L. leaf extracts

inferred← citeshttps://doi.org/10.1016/j.jep.2026.122298openalex-snapshot

Phytochemical characterization, pharmacological activities, and in silico analysis of the methanolic extract of reishi mushroom (Ganoderma lucidum)

inferred← citeshttps://doi.org/10.1016/j.jep.2026.122490openalex-snapshot

Phytochemical profiling and multi-target wound-healing potential of Millettia extensa (Benth.) Baker stem bark extracts: Integrated computational and experimental validation

inferred← citeshttps://doi.org/10.1016/j.joim.2020.10.001openalex-snapshot

Chrysobalanus icaco: A review of its phytochemistry and pharmacology

inferred← citeshttps://doi.org/10.1016/j.jsps.2018.09.001openalex-snapshot

Chemical composition and biological activity of the essential oil from the root of Jatropha pelargoniifolia Courb. native to Saudi Arabia

inferred← citeshttps://doi.org/10.1016/j.jsps.2020.09.021openalex-snapshot

Withametelin: a biologically active withanolide in cancer, inflammation, pain and depression

inferred← citeshttps://doi.org/10.1016/j.jtcme.2016.11.006openalex-snapshot

Validation of therapeutic anti-inflammatory potential of Arjuna Ksheera Paka – A traditional Ayurvedic formulation of Terminalia arjuna

inferred← citeshttps://doi.org/10.1016/j.lfs.2015.08.010openalex-snapshot

Anti-inflammatory and antinociceptive effects of racemic goniothalamin, a styryl lactone

inferred← citeshttps://doi.org/10.1016/j.lfs.2016.03.034openalex-snapshot

Fish oil attenuates persistent inflammatory pain in rats through modulation of TNF-α and resolvins

inferred← citeshttps://doi.org/10.1016/j.lfs.2019.05.004openalex-snapshot

Bio-isosteric replacement of amide group with 1,2,3-triazole in phenacetin improves the toxicology and efficacy of phenacetin-triazole conjugates (PhTCs)

inferred← citeshttps://doi.org/10.1016/j.microb.2024.100050openalex-snapshot

Lactobacillus species modulates TNF-α and Nrf2 expression in carrageenan-induced rat paw oedema

inferred← citeshttps://doi.org/10.1016/j.neuropharm.2022.109276openalex-snapshot

(2R,6R)-hydroxynorketamine (HNK) reverses mechanical hypersensitivity in a model of localized inflammatory pain

inferred← citeshttps://doi.org/10.1016/j.phymed.2010.08.013openalex-snapshot

Escin exerts synergistic anti-inflammatory effects with low doses of glucocorticoids in vivo and in vitro

inferred← citeshttps://doi.org/10.1016/j.phytol.2016.12.002openalex-snapshot

Flavonol glycosides from the leaves of Boldoa purpurascens and their anti-inflammatory properties

inferred← citeshttps://doi.org/10.1016/j.phytol.2024.03.013openalex-snapshot

Phenolic-rich extract from Bryophyllum pinnatum leaf cultivated under drought stress conditions modulates the antioxidant and anti-inflammatory response

inferred← citeshttps://doi.org/10.1016/j.plefa.2008.08.001openalex-snapshot

COX-2 expression and function in the hyperalgesic response to paw inflammation in mice

inferred← citeshttps://doi.org/10.1016/j.prenap.2026.100769openalex-snapshot

Dual COX/LOX inhibition and anti-edematous activity of Jasminum azoricum L. extract: A pharmacological evaluation

inferred← citeshttps://doi.org/10.1016/j.rsma.2026.105427openalex-snapshot

LC-MS-based chemical profiling and in vivo anti-inflammatory effects of the Vietnamese red alga Tricleocarpa cylindrica

inferred← citeshttps://doi.org/10.1016/j.sajb.2017.08.015openalex-snapshot

In vivo anti-inflammatory and analgesic activities of Cistus salviifolius (L.) and Cistus monspeliensis (L.) aqueous extracts

inferred← citeshttps://doi.org/10.1016/j.sajb.2024.03.024openalex-snapshot

Phytochemical characterization and biological activities evaluation of Opuntia sp. cladodes

inferred← citeshttps://doi.org/10.1016/j.sjbs.2015.10.004openalex-snapshot

Evaluation of chemical composition and antiedematogenic activity of the essential oil of Hyptis martiusii Benth

inferred← citeshttps://doi.org/10.1016/j.sjbs.2021.08.006openalex-snapshot

Antinociceptive and anti-inflammatory activities of butein in different nociceptive and inflammatory mice models

inferred← citeshttps://doi.org/10.1016/j.sjbs.2023.103606openalex-snapshot

The anti-inflammatory activity of the compounds isolated from Dichroa febrifuga leaves

inferred← citeshttps://doi.org/10.1016/j.tet.2009.10.026openalex-snapshot

Perthamides C and D, two new potent anti-inflammatory cyclopeptides from a Solomon Lithistid sponge Theonella swinhoei

inferred← citeshttps://doi.org/10.1016/j.tet.2010.07.060openalex-snapshot

Concise synthesis of AHMHA unit in perthamide C. Structural and stereochemical revision of perthamide C

inferred← citeshttps://doi.org/10.1016/j.toxicon.2007.01.017openalex-snapshot

Long-lasting anti-inflammatory properties of Crotalus durissus terrificus snake venom in mice

inferred← citeshttps://doi.org/10.1016/j.toxicon.2013.01.023openalex-snapshot

Dexamethasone antagonizes the in vivo myotoxic and inflammatory effects of Bothrops venoms

inferred← citeshttps://doi.org/10.1016/j.toxicon.2015.02.010openalex-snapshot

Occurrence of sulfated fucose branches in fucosylated chondroitin sulfate are essential for the polysaccharide effect preventing muscle damage induced by toxins and crude venom from Bothrops jararacussu snake

inferred← citeshttps://doi.org/10.1016/j.toxicon.2016.11.260openalex-snapshot

Inhibition of local effects induced by Bothrops erythromelas snake venom: Assessment of the effectiveness of Brazilian polyvalent bothropic antivenom and aqueous leaf extract of Jatropha gossypiifolia

inferred← citeshttps://doi.org/10.1016/j.toxicon.2020.02.025openalex-snapshot

Mangaba (Hancornia speciosa Gomes) fruit juice decreases acute pulmonary edema induced by Tityus serrulatus venom: Potential application for auxiliary treatment of scorpion stings

inferred← citeshttps://doi.org/10.1016/j.toxicon.2026.109238openalex-snapshot

Eclipta prostrata extract and wedelolactone antagonize Apis mellifera venom activities

inferred← citeshttps://doi.org/10.1016/j.yrtph.2020.104762openalex-snapshot

Effects of an ethanolic extract and fractions from Piper glabratum (Piperaceae) leaves on pain and inflammation

inferred← citeshttps://doi.org/10.1016/s1734-1140(12)70895-2openalex-snapshot

Comparative study of the anti-edematogenic effects of anethole and estragole

inferred← citeshttps://doi.org/10.1016/s1734-1140(13)71037-5openalex-snapshot

Peripheral antinociception and anti-edematogenic effect of a sulfated polysaccharide from Acanthophora muscoides

inferred← citeshttps://doi.org/10.1016/s1875-5364(18)30036-0openalex-snapshot

Anti-inflammatory effect of external use of escin on cutaneous inflammation: possible involvement of glucocorticoids receptor

inferred← citeshttps://doi.org/10.1021/acs.molpharmaceut.6b00504openalex-snapshot

Single Intravenous Dose of Novel Flurbiprofen-Loaded Proniosome Formulations Provides Prolonged Systemic Exposure and Anti-inflammatory Effect

inferred← citeshttps://doi.org/10.1021/acsnanoscienceau.1c00016openalex-snapshot

Click-Ready Perfluorocarbon Nanoemulsion for 19 F MRI and Multimodal Cellular Detection

inferred← citeshttps://doi.org/10.1021/acsomega.0c01775openalex-snapshot

Anti-Inflammatory, Antinociceptive, and Antioxidant Properties of Anacardic Acid in Experimental Models

inferred← citeshttps://doi.org/10.1021/acsptsci.5c00431openalex-snapshot

3-(4-Hydroxyphenyl-1,2,3-Triazol-1-yl)Quinuclidine, a Selective α7 Nicotinic Acetylcholine Receptor Agonist, Attenuates Inflammatory Pain with a Favorable Central Nervous System Safety Profile in Mice

inferred← citeshttps://doi.org/10.1021/bi7006349openalex-snapshot

Haptoglobin Binding to Apolipoprotein A-I Prevents Damage from Hydroxyl Radicals on Its Stimulatory Activity of the Enzyme Lecithin-Cholesterol Acyl-Transferase

inferred← citeshttps://doi.org/10.1021/jm900051ropenalex-snapshot

Galactosyl Prodrug of Ketorolac: Synthesis, Stability, and Pharmacological and Pharmacokinetic Evaluations

inferred← citeshttps://doi.org/10.1024/0300-9831/a000620openalex-snapshot

Reduction of paw edema and liver oxidative stress in carrageenan-induced acute inflammation by Lobaria pulmonaria and Parmelia caperata, lichen species, in mice

inferred← citeshttps://doi.org/10.1024/0300-9831/a000739openalex-snapshot

Increased anti-inflammatory activity and enhanced phytochemical concentrations in superfine powders obtained by controlled differential sieving process from four medicinal plants

inferred← citeshttps://doi.org/10.1038/s41393-018-0144-5openalex-snapshot

Time-dependent changes in paw carrageenan-induced inflammation above and below the level of low thoracic spinal cord injury in rats

inferred← citeshttps://doi.org/10.1038/s41598-025-18825-xopenalex-snapshot

Pharmacokinetic and phytochemical screening of Allium subhirsutum leaves for antimicrobial and anti-inflammatory properties

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