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Prostaglandin E2 activates EP2 receptors to inhibit human lung mast cell degranulation

https://doi.org/10.1038/sj.bjp.0706664
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1007/bf01983121openalex-snapshot
Isolation and properties of cardiac and other mast cells from the rat and guinea-pig
inferredcites →https://doi.org/10.1016/0003-2697(74)90093-1openalex-snapshot
An automated continuous-flow system for the extraction and fluorometric analysis of histamine
inferredcites →https://doi.org/10.1016/0091-6749(88)90199-6openalex-snapshot
Human mast cell heterogeneity: Histamine release from mast cells dispersed from skin, lung, adenoids, tonsils, and colon in response to IgE-dependent and nonimmunologic stimuli
inferredcites →https://doi.org/10.1016/0165-6147(83)90345-0openalex-snapshot
Mast cell heterogeneity
inferredcites →https://doi.org/10.1016/j.ejphar.2004.08.025openalex-snapshot
Functional pharmacology of human prostanoid EP2 and EP4 receptors
inferredcites →https://doi.org/10.1016/j.it.2003.11.001openalex-snapshot
The lung as a privileged site for the beneficial actions of PGE2
inferredcites →https://doi.org/10.1016/j.jaci.2005.02.022openalex-snapshot
Surface CD88 functionally distinguishes the MCTC from the MCT type of human lung mast cell
inferredcites →https://doi.org/10.1016/s0026-895x(24)23081-9openalex-snapshot
Importance of the Extracellular Domain for Prostaglandin EP2 Receptor Function
inferredcites →https://doi.org/10.1016/s0026-895x(25)09407-6openalex-snapshot
Two Gs-coupled prostaglandin E receptor subtypes, EP2 and EP4, differ in desensitization and sensitivity to the metabolic inactivation of the agonist.
inferredcites →https://doi.org/10.1016/s0031-6997(25)06784-5openalex-snapshot
International Union of Pharmacology classification of prostanoid receptors: properties, distribution, and structure of the receptors and their subtypes.
inferredcites →https://doi.org/10.1016/s0091-6749(00)90056-3openalex-snapshot
Mast-cell responses in the development of asthma
inferredcites →https://doi.org/10.1016/s0091-6749(86)80104-xopenalex-snapshot
The mast cell as a primary effector cell in the pathegenesis of asthma
inferredcites →https://doi.org/10.1016/s0091-6749(99)70157-0openalex-snapshot
Role of cyclic 3 ,5 -adenosine monophosphate in the regulation of chemical mediator release and cytokine production from cultured human mast cells
inferredcites →https://doi.org/10.1016/s0306-3623(98)00080-9openalex-snapshot
Regulation of Human Mast Cell and Basophil Function by cAMP
inferredcites →https://doi.org/10.1016/s1388-1981(99)00164-xopenalex-snapshot
The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogs
inferredcites →https://doi.org/10.1016/s1471-4906(01)02154-8openalex-snapshot
Prostaglandins as modulators of immunity
inferredcites →https://doi.org/10.1021/bi00252a016openalex-snapshot
Isoforms of the EP3 Subtype of Human Prostaglandin E2 Receptor Transduce Both Intracellular Calcium and cAMP Signals
inferredcites →https://doi.org/10.1038/sj.bjp.0701367openalex-snapshot
Ligand binding specificities of the eight types and subtypes of the mouse prostanoid receptors expressed in Chinese hamster ovary cells
inferredcites →https://doi.org/10.1038/sj.bjp.0701703openalex-snapshot
Salmeterol inhibition of mediator release from human lung mast cells by β‐adrenoceptor‐dependent and independent mechanisms
inferredcites →https://doi.org/10.1038/sj.bjp.0701897openalex-snapshot
Influence of receptor reserve on β‐adrenoceptor‐mediated responses in human lung mast cells
inferredcites →https://doi.org/10.1038/sj.bjp.0702392openalex-snapshot
Prostanoid receptors involved in the relaxation of human bronchial preparations
inferredcites →https://doi.org/10.1038/sj.bjp.0703072openalex-snapshot
Characterization of prostanoid receptors mediating inhibition of histamine release from anti‐IgE‐activated rat peritoneal mast cells
inferredcites →https://doi.org/10.1038/sj.bjp.0705716openalex-snapshot
Identification in human airways smooth muscle cells of the prostanoid receptor and signalling pathway through which PGE2 inhibits the release of GM‐CSF
inferredcites →https://doi.org/10.1067/mai.2000.106485openalex-snapshot
The diverse potential effector and immunoregulatory roles of mast cells in allergic disease
inferredcites →https://doi.org/10.1067/mai.2000.108107openalex-snapshot
Regulation of chymase production in human mast cell progenitors
inferredcites →https://doi.org/10.1067/mai.2003.25openalex-snapshot
Roles of cysteinyl leukotrienes in airway inflammation, smooth muscle function, and remodeling
inferredcites →https://doi.org/10.1111/j.1432-1033.1993.tb18248.xopenalex-snapshot
Third isoform of the prostaglandin‐E‐receptor EP3 subtype with different C‐terminal tail coupling to both stimulation and inhibition of adenylate cyclase
inferredcites →https://doi.org/10.1124/jpet.103.049650openalex-snapshot
Role of Cyclooxygenase-1 and -2, Phospholipase C, and Protein Kinase C in Prostaglandin-Mediated Gastroprotection
inferredcites →https://doi.org/10.1124/mol.51.2.343openalex-snapshot
The Long Cytoplasmic Carboxyl Terminus of the Prostaglandin E2 Receptor EP4 Subtype Is Essential for Agonist-Induced Desensitization
inferredcites →https://doi.org/10.1146/annurev.pharmtox.41.1.661openalex-snapshot
Prostanoid Receptors: Subtypes and Signaling
inferredcites →https://doi.org/10.1164/ajrccm.159.1.9804030openalex-snapshot
Protective Effects of Inhaled PGE2 on Allergen-induced Airway Responses and Airway Inflammation
inferredcites →https://doi.org/10.1164/ajrccm.162.2.9904038openalex-snapshot
Prostaglandin E2 Decreases Allergen-stimulated Release of Prostaglandin D2 in Airways of Subjects with Asthma
inferredcites →https://doi.org/10.1172/jci13416openalex-snapshot
Mixed messages: modulation of inflammation and immune responses by prostaglandins and thromboxanes
inferredcites →https://doi.org/10.1172/jci200113416openalex-snapshot
Mixed messages: modulation of inflammation and immune responses by prostaglandins and thromboxanes
inferredcites →https://doi.org/10.1172/jci8124openalex-snapshot
Airway remodeling in asthma
inferredcites →https://doi.org/10.1182/blood.v46.2.279.279openalex-snapshot
Basophil counting with a new staining method using alcian blue
inferredcites →https://doi.org/10.4049/jimmunol.129.6.2662openalex-snapshot
Human lung mast cells: purification and characterization.
inferredcites →https://doi.org/10.4049/jimmunol.130.5.2357openalex-snapshot
Biochemical analysis of initial triggering events of IgE-mediated histamine release from human lung mast cells.
inferredcites →https://doi.org/10.4049/jimmunol.169.8.4586openalex-snapshot
Receptors and Signaling Mechanisms Required for Prostaglandin E2-Mediated Regulation of Mast Cell Degranulation and IL-6 Production
inferredcites →https://doi.org/10.4049/jimmunol.172.2.1227openalex-snapshot
Prostaglandin E2 Induces Degranulation-Independent Production of Vascular Endothelial Growth Factor by Human Mast Cells

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Prostanoids
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Distinct eicosanoid patterns in severe recalcitrant nasal polyposis
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Rapamycin and Suramin Effects on TNF‐⍺‐Mediated Mast Cell and Brain Microvascular Endothelial Cell Dysfunction
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Engagement of the EP2 prostanoid receptor closes the K+ channel KCa3.1 in human lung mast cells and attenuates their migration
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Prostaglandin regulation of type 2 inflammation: From basic biology to therapeutic interventions
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Human Umbilical Cord Blood Mesenchymal Stem Cell-Derived PGE2 and TGF-β1 Alleviate Atopic Dermatitis by Reducing Mast Cell Degranulation
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Aspirin-Exacerbated Respiratory Disease
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Regulation of FcεRI Signaling by Lipid Phosphatases
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Lipidmediatoren und ihre Rolle bei Entzündungen und Allergien
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Pharmacological treatment options for mast cell activation disease
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Impact of ozone exposure on prostaglandin release in nasal polyps
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Prostanoids and the Cough Reflex
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Mast-Cell-Releasing Tryptase Triggers Acute Lung Injury Induced by Small Intestinal Ischemia–Reperfusion by Activating PAR-2 in Rats
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Critical pathomechanisms of NSAID-exacerbated respiratory disease (N-ERD) clarified by treatment with omalizumab, an anti-IgE antibody
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Lipid mediators and allergic diseases
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Suppression of aspirin-mediated eosinophil activation by prostaglandin E2
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Un inhibidor selectivo de la ciclooxigenasa-2 empeora la función respiratoria y fomenta la actividad de los mastocitos en ratones sensibilizados a la ovalbúmina
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Mast cells and inflammation
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Synergistic activation of phospholipases Cγ and Cβ: A novel mechanism for PI3K-independent enhancement of FcεRI-induced mast cell mediator release
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Mast cell-specific CysLT2 receptor signaling inhibits cysteinyl leukotriene-dependent mast cell activation and type 2 allergic lung inflammation
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Positive and negative roles of lipids in mast cells and allergic responses
inferred← citeshttps://doi.org/10.1016/j.ejphar.2017.11.017openalex-snapshot
Evidence for autocrine and paracrine regulation of allergen-induced mast cell mediator release in the guinea pig airways
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Pathogenesis of Aspirin-Induced Reactions in Aspirin-Exacerbated Respiratory Disease
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Lipid Mediators in Aspirin-Exacerbated Respiratory Disease
inferred← citeshttps://doi.org/10.1016/j.imlet.2007.08.007openalex-snapshot
G protein-coupled receptors and the modification of FcɛRI-mediated mast cell activation
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Distinct PGE2-responder and non-responder phenotypes in human mast cell populations: “All or nothing” enhancement of antigen-dependent mediator release
inferred← citeshttps://doi.org/10.1016/j.immuni.2024.05.003openalex-snapshot
Mast cells control lung type 2 inflammation via prostaglandin E2-driven soluble ST2
inferred← citeshttps://doi.org/10.1016/j.intimp.2006.12.010openalex-snapshot
Comparison of the influence of NSAIDs with different COX-selectivity on histamine release from mast cells isolated from naïve and sensitized rats
inferred← citeshttps://doi.org/10.1016/j.jaci.2012.02.007openalex-snapshot
Reduced expression of the prostaglandin E2 receptor E-prostanoid 2 on bronchial mucosal leukocytes in patients with aspirin-sensitive asthma
inferred← citeshttps://doi.org/10.1016/j.jaci.2015.04.002openalex-snapshot
Prostaglandin E2 inhibits mast cell–dependent bronchoconstriction in human small airways through the E prostanoid subtype 2 receptor
inferred← citeshttps://doi.org/10.1016/j.jaci.2017.09.050openalex-snapshot
Prostaglandin E2 suppresses human group 2 innate lymphoid cell function
inferred← citeshttps://doi.org/10.1016/j.jaci.2018.02.006openalex-snapshot
Role of lipid mediators and control of lymphocyte responses in type 2 immunopathology
inferred← citeshttps://doi.org/10.1016/j.jaci.2019.08.022openalex-snapshot
Aspirin sensitivity: Lessons in the regulation (and dysregulation) of mast cell function
inferred← citeshttps://doi.org/10.1016/j.jaci.2020.03.046openalex-snapshot
PGE2 deficiency predisposes to anaphylaxis by causing mast cell hyperresponsiveness
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Innate immune cell dysregulation drives inflammation and disease in aspirin-exacerbated respiratory disease
inferred← citeshttps://doi.org/10.1016/j.jaci.2022.03.029openalex-snapshot
Advances in mast cell biology
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Updates on immune mechanisms in aspirin-exacerbated respiratory disease
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IgE-activated human lung mast cells preferentially release prostaglandin D2, thromboxane A2, and cysteinyl-leukotrienes
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The PGE2–EP2–mast cell axis: An antiasthma mechanism
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Mast cell and eosinophil surface receptors as targets for anti-allergic therapy
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The Role of PGE2 and EP Receptors on Lung's Immune and Structural Cells; Possibilities for Future Asthma Therapy
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Pathogenesis of NSAID‐induced reactions in aspirin‐exacerbated respiratory disease
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A Cyclooxygenase-2 Selective Inhibitor Worsens Respiratory Function and Enhances Mast Cell Activity in Ovalbumin-Sensitized Mice
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Multiomics characteristics of neurogenesis-related gene are dysregulated in tumor immune microenvironment
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Mast cell phenotype, TNFα expression and degranulation status in non-small cell lung cancer
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Dynamic model of eicosanoid production with special reference to non‐steroidal anti‐inflammatory drug‐triggered hypersensitivity
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Aspirin-Exacerbated Respiratory Disease — New Prime Suspects
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Prostaglandin E 2 deficiency causes a phenotype of aspirin sensitivity that depends on platelets and cysteinyl leukotrienes
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Prostaglandin E2 Activates and Utilizes mTORC2 as a Central Signaling Locus for the Regulation of Mast Cell Chemotaxis and Mediator Release
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Current complications and treatment of aspirin-exacerbated respiratory disease
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Antiglaucoma EP 2 Agonists: A Long Road That Led Somewhere
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Prostaglandin E2 in NSAID-exacerbated respiratory disease: protection against cysteinyl leukotrienes and group 2 innate lymphoid cells
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New insights into the mechanisms of aspirin-exacerbated respiratory disease
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Update on aspirin exacerbated respiratory disease with chronic rhinosinusitis
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Subphenotypes of nonsteroidal antiinflammatory disease‐exacerbated respiratory disease identified by latent class analysis
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Transgenic mice overexpressing the PGE2 receptor EP2 on mast cells exhibit a protective phenotype in a model of allergic asthma
inferred← citeshttps://doi.org/10.1111/bph.14525openalex-snapshot
The affinity, intrinsic activity and selectivity of a structurally novel EP 2 receptor agonist at human prostanoid receptors
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Characterization of the EP receptor subtype that mediates the inhibitory effects of prostaglandin E2on IgE‐dependent secretion from human lung mast cells
inferred← citeshttps://doi.org/10.1111/cea.12542openalex-snapshot
Activation of the Prostaglandin E2 receptor EP 2 prevents house dust mite‐induced airway hyperresponsiveness and inflammation by restraining mast cells’ activity
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Cyclooxygenase 2: its regulation, role and impact in airway inflammation
inferred← citeshttps://doi.org/10.1111/imr.12625openalex-snapshot
Changing the threshold—Signals and mechanisms of mast cell priming
inferred← citeshttps://doi.org/10.1111/imr.12629openalex-snapshot
Non‐IgE mediated mast cell activation
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Bone marrow stromal cells inhibit mast cell function via a COX2‐dependent mechanism
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PGE2 suppresses excessive anti‐IgE induced cysteinyl leucotrienes production in mast cells of patients with aspirin exacerbated respiratory disease
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Protease‐activated receptors and prostaglandins in inflammatory lung disease
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Candida albicansabrogates the expression of interferon-γ-inducible protein-10 in human keratinocytes
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Differential release of mast cell mediators and the pathogenesis of inflammation
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Prostaglandin E2 Inhibits Advanced Glycation End Product-Induced Adhesion Molecule Expression, Cytokine Production, and Lymphocyte Proliferation in Human Peripheral Blood Mononuclear Cells
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Effect of Nicotine on Advanced Glycation End Product-Induced Immune Response in Human Monocytes
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Prostaglandin E2 Inhibits Advanced Glycation End Product-Induced Adhesion Molecule Expression on Monocytes, Cytokine Production, and Lymphocyte Proliferation during Human Mixed Lymphocyte Reaction
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International Union of Basic and Clinical Pharmacology. LXXXIII: Classification of Prostanoid Receptors, Updating 15 Years of Progress
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The occurrence of refractoriness and mast cell mediator release following mannitol-induced bronchoconstriction
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Role of in Asthma and Nonasthmatic Eosinophilic Bronchitis
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Mechanisms of Aspirin-Sensitive Respiratory Disease – A Two-Compartment Model
inferred← citeshttps://doi.org/10.1159/000205578openalex-snapshot
Subcutaneous Prostaglandin E2 Restrains Airway Mast Cell Activity in vivo and Reduces Lung Eosinophilia and Th2 Cytokine Overproduction in House Dust Mite-Sensitive Mice
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Prostaglandin E2 Mediates Cough via the EP3 Receptor: Implications for Future Disease Therapy
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Acetylsalicylic acid aggravates anaphylaxis in a PGE2-dependent manner
inferred← citeshttps://doi.org/10.1186/1476-9255-6-30openalex-snapshot
Activity of the cyclooxygenase 2-prostaglandin-E prostanoid receptor pathway in mice exposed to house dust mite aeroallergens, and impact of exogenous prostaglandin E2
inferred← citeshttps://doi.org/10.1186/1478-811x-11-86openalex-snapshot
Proteinase-activated receptors (PARs) – focus on receptor-receptor-interactions and their physiological and pathophysiological impact
inferred← citeshttps://doi.org/10.1186/s12931-014-0100-7openalex-snapshot
Prostaglandin E2 receptors in asthma and in chronic rhinosinusitis/nasal polyps with and without aspirin hypersensitivity
inferred← citeshttps://doi.org/10.1186/s40360-026-01098-zopenalex-snapshot
Identifying key molecular interactions and pathways linking DEHP and its metabolite MEHP to allergic rhinitis: a network toxicology and molecular dynamics study
inferred← citeshttps://doi.org/10.1189/jlb.0212109openalex-snapshot
E-prostanoid 2 receptors dampen mast cell degranulation via cAMP/PKA-mediated suppression of IgE-dependent signaling
inferred← citeshttps://doi.org/10.1189/jlb.0612314openalex-snapshot
Editorial: Space flight modifies T cell activation—role of microgravity
inferred← citeshttps://doi.org/10.1189/jlb.0812374openalex-snapshot
Editorial: Yin-Yang of EP receptor expression
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Frontline Science: Corticotropin-releasing factor receptor subtype 1 is a critical modulator of mast cell degranulation and stress-induced pathophysiology
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[Altered expression of 15-hydroxyprostaglandin dehydrogenase in chronic rhinosinusitis with nasal polyps].
inferred← citeshttps://doi.org/10.1371/journal.pone.0110870openalex-snapshot
Prostaglandin E2 Prevents Hyperosmolar-Induced Human Mast Cell Activation through Prostanoid Receptors EP2 and EP4
inferred← citeshttps://doi.org/10.1371/journal.pone.0200989openalex-snapshot
Expression of E-prostanoid receptors in nasal polyp tissues of smoking and nonsmoking patients with chronic rhinosinusitis
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Novel biomarkers for asthma stratification and personalized therapy
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Regulation of Mast Cell Responses in Health and Disease
inferred← citeshttps://doi.org/10.2147/jaa.s237463openalex-snapshot
The Role of Mast Cells in Aspirin-Exacerbated Respiratory Disease (AERD) Pathogenesis: Implications for Future Therapeutics
inferred← citeshttps://doi.org/10.2147/jaa.s88739openalex-snapshot
Aspirin-exacerbated respiratory disease: pathophysiological insights and clinical advances
inferred← citeshttps://doi.org/10.2500/ajra.2015.29.4205openalex-snapshot
Expression Profiles of Prostaglandin E 2 Receptor Subtypes in Aspirin Tolerant Adult Chinese with Chronic Rhinosinusitis
inferred← citeshttps://doi.org/10.3389/fcell.2020.00326openalex-snapshot
Mesenchymal Stem Cells and Atopic Dermatitis: A Review
inferred← citeshttps://doi.org/10.3389/fimmu.2012.00119openalex-snapshot
Mast Cell Chemotaxis – Chemoattractants and Signaling Pathways
inferred← citeshttps://doi.org/10.3389/fimmu.2017.00424openalex-snapshot
Are Mast Cells MASTers in Cancer?
inferred← citeshttps://doi.org/10.3389/fimmu.2018.02006openalex-snapshot
Eicosanoid Control Over Antigen Presenting Cells in Asthma
inferred← citeshttps://doi.org/10.3390/cells15201848openalex-snapshot
Fibroblast-Derived PLA2G12A Amplifies Mast Cell Activation Through Extracellular Phospholipid Remodeling
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Future Needs in Mast Cell Biology
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The Biology of Prostaglandins and Their Role as a Target for Allergic Airway Disease Therapy
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Prostaglandin E2–EP3 Signaling Induces Inflammatory Swelling by Mast Cell Activation
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Aspirin-Exacerbated Respiratory Disease Involves a Cysteinyl Leukotriene–Driven IL-33–Mediated Mast Cell Activation Pathway
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Usage of corticosteroids as therapeutic agents in diseases
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In VitroandIn VivoValidation of EP2-Receptor Agonism to Selectively Achieve Inhibition of Mast Cell Activity
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