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Intermittent hypoxia attenuates ischemia/reperfusion induced apoptosis in cardiac myocytes via regulating Bcl-2/Bax expression

https://doi.org/10.1038/sj.cr.7290184

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Cardiac functional improvement by a human Bcl-2 transgene in a mouse model of ischemia/reperfusion injury

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Prevention and elimination of heart arrhythmias by adaptation to intermittent high altitude hypoxia

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Acute Myocardial Infarction in Humans is Associated with Activation of Programmed Myocyte Cell Death in the Surviving Portion of the Heart

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Adaptation to High Altitude Hypoxia Protects the Rat Heart Against Ischemia-induced Arrhythmias. Involvement of Mitochondrial KATPChannel

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Adaptation to high altitude hypoxia as a factor preventing development of myocardial ischemic necrosis

inferredcites →https://doi.org/10.1016/0092-8674(93)80066-nopenalex-snapshot

Bcl-2 functions in an antioxidant pathway to prevent apoptosis

inferredcites →https://doi.org/10.1016/0092-8674(93)90509-oopenalex-snapshot

Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programed cell death

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Effects of mitochondrial KATP modulators on cardioprotection induced by chronic high altitude hypoxia in rats

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Ischemic preconditioning attenuates ischemia/reperfusion-induced activation of caspases and subsequent cleavage of poly(ADP-ribose) polymerase in rat hearts in vivo

inferredcites →https://doi.org/10.1016/s0008-6363(99)00354-5openalex-snapshot

Reperfusion induces myocardial apoptotic cell death

inferredcites →https://doi.org/10.1016/s0008-6363(99)00393-4openalex-snapshot

Preconditioning decreases Bax expression, PMN accumulation and apoptosis in reperfused rat heart

inferredcites →https://doi.org/10.1016/s0024-3205(00)00832-8openalex-snapshot

Effects of intermittent hypoxia on action potential and contraction in non-ischemic and ischemic rat papillary muscle

inferredcites →https://doi.org/10.1016/s0304-3940(99)00047-6openalex-snapshot

Oxidative stress is attenuated in mice overexpressing BCL-2

inferredcites →https://doi.org/10.1023/a:1006883717174openalex-snapshot

Ischemic preconditioning attenuates apoptotic cell death associated with ischemia/reperfusion

inferredcites →https://doi.org/10.1023/a:1012772931313openalex-snapshot

Bcl-2/Bax protein expression in heart, slow-twitch and fast-twitch muscles in young rats growing under chronic hypoxia conditions

inferredcites →https://doi.org/10.1038/sj.cr.7290050openalex-snapshot

Effect of Bcl-2 and caspase-3 on calcium distribution in apoptosis of HL-60 cell

inferredcites →https://doi.org/10.1038/sj.cr.7290052openalex-snapshot

Expression of Bcl-2 inhibited Fas-mediated apoptosis in human hepatocellular carcinoma BEL-7404 cells

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Bcl-2 over-expression and activation of protein kinase C suppress the Trail-induced apoptosis in Jurkat T cells

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Role of hypoxia-induced Bax translocation and cytochrome c release in reoxygenation injury

inferredcites →https://doi.org/10.1046/j.1365-201x.2001.00851.xopenalex-snapshot

Intermittent hypoxia improves atrial tolerance to subsequent anoxia and reduces stress protein expression

inferredcites →https://doi.org/10.1073/pnas.97.11.5723openalex-snapshot

Bcl-2 decreases the free Ca 2+ concentration within the endoplasmic reticulum

inferredcites →https://doi.org/10.1089/15270290050074279openalex-snapshot

Physiological Effects of Intermittent Hypoxia

inferredcites →https://doi.org/10.1093/emboj/17.14.3878openalex-snapshot

Enforced dimerization of BAX results in its translocation, mitochondrial dysfunction and apoptosis

inferredcites →https://doi.org/10.1126/science.281.5381.1322openalex-snapshot

The Bcl-2 Protein Family: Arbiters of Cell Survival

inferredcites →https://doi.org/10.1146/annurev.immunol.16.1.395openalex-snapshot

BCL-2 FAMILY: Regulators of Cell Death

inferredcites →https://doi.org/10.1152/ajpcell.2001.280.6.c1475openalex-snapshot

Twisting integrin receptors increases endothelin-1 gene expression in endothelial cells

inferredcites →https://doi.org/10.1152/ajpheart.2001.280.5.h2313openalex-snapshot

Overexpression of Bcl-2 attenuates apoptosis and protects against myocardial I/R injury in transgenic mice

inferredcites →https://doi.org/10.1161/01.cir.100.suppl_2.ii-369openalex-snapshot

Ischemic Preconditioning Reduces Apoptosis By Upregulating Anti-Death Gene Bcl-2

inferredcites →https://doi.org/10.1161/01.cir.74.5.1124openalex-snapshot

Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium.

inferredcites →https://doi.org/10.1161/01.res.79.5.949openalex-snapshot

Apoptosis in Ischemic and Reperfused Rat Myocardium

inferredcites →https://doi.org/10.1172/jci117504openalex-snapshot

Reperfusion injury induces apoptosis in rabbit cardiomyocytes.

inferredcites →https://doi.org/10.1172/jci118683openalex-snapshot

Preconditioning rabbit cardiomyocytes: role of pH, vacuolar proton ATPase, and apoptosis.

inferredcites →https://doi.org/10.1177/153537020222700604openalex-snapshot

Chronic and Intermittent Hypoxia Induce Different Degrees of Myocardial Tolerance to Hypoxia-Induced Dysfunction

inferredcites →https://doi.org/10.1177/41.1.7678025openalex-snapshot

A new method to detect apoptosis in paraffin sections: in situ end-labeling of fragmented DNA.

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Luteolin Limits Infarct Size and Improves Cardiac Function after Myocardium Ischemia/Reperfusion Injury in Diabetic Rats

inferred← citeshttps://doi.org/10.14744/anatoljcardiol.2018.00236openalex-snapshot

Intermittent Hypoxia Induced Beneficial Cardiovascular Remodeling in Left Ventricular Function of Type 1 Diabetic Rat

inferred← citeshttps://doi.org/10.1536/ihj.22-036openalex-snapshot

MiR-7015-3p Targets Nuclear Factor-Kappa-B-Inhibitor Alpha to Aggravate Hypoxia/Reoxygenation Injury in Cardiomyocytes Through the NF-κB Pathway

inferred← citeshttps://doi.org/10.15407/ubj89.06.039openalex-snapshot

Changes in proHB-EGF expression after functional activation of the immune system cells

inferred← citeshttps://doi.org/10.17352/aprc.000022openalex-snapshot

Hypoxia/Reoxygenation modulates Oxidative Stress Level and Antioxidative Potential in Lung Mitochondria: Possible participation of P53 and NF-KB Target Proteins

inferred← citeshttps://doi.org/10.21608/besps.2007.37136openalex-snapshot

Chronic Intermittent Hypoxia Protects the Rat Heart Against Ischemic/Reperfusion Injury by Modulating Apoptosis: A Possible Role for Endogenous Nitric Oxide

inferred← citeshttps://doi.org/10.2174/092986711796642553openalex-snapshot

Ischemia - Reperfusion: A Look from Yeast Mitochondria

inferred← citeshttps://doi.org/10.3345/kjp.2008.51.10.1102openalex-snapshot

Neuroprotective effects of resveratrol via anti-apoptosis on hypoxic-ischemic brain injury in neonatal rats

inferred← citeshttps://doi.org/10.3349/ymj.2010.51.2.187openalex-snapshot

Cardioprotection Via Modulation of Calcium Homeostasis by Thiopental in Hypoxia-Reoxygenated Neonatal Rat Cardiomyocytes

inferred← citeshttps://doi.org/10.33549/physiolres.930000.53.s3openalex-snapshot

Molecular mechanisms of cardiac protection by adaptation to chronic hypoxia.

inferred← citeshttps://doi.org/10.3389/fped.2015.00058openalex-snapshot

Hypoxic Conditioning as a New Therapeutic Modality

inferred← citeshttps://doi.org/10.3389/fphar.2020.565160openalex-snapshot

Irisin Attenuates Myocardial Ischemia/Reperfusion Injury and Improves Mitochondrial Function Through AMPK Pathway in Diabetic Mice

inferred← citeshttps://doi.org/10.3389/fphar.2023.1097641openalex-snapshot

Improvement of obesity-induced fatty liver disease by intermittent hypoxia exposure in a murine model

inferred← citeshttps://doi.org/10.3892/etm.2021.10836openalex-snapshot

Protective effects of safranal on hypoxia/reoxygenation‑induced injury in H9c2 cardiac myoblasts via the PI3K/AKT/GSK3β signaling pathway

inferred← citeshttps://doi.org/10.3892/ijmm.2018.3743openalex-snapshot

Protective effect of morin on myocardial ischemia‑reperfusion injury in rats

inferred← citeshttps://doi.org/10.3892/ijmm.2019.4264openalex-snapshot

Hydrogen-rich saline alleviates inflammation and apoptosis in myocardial I/R�injury via PINK-mediated autophagy

inferred← citeshttps://doi.org/10.3892/mmr.2014.2292openalex-snapshot

N-acetylcysteine reduces oxidative stress, nuclear factor-κB activity and cardiomyocyte apoptosis in heart failure

inferred← citeshttps://doi.org/10.3892/mmr.2021.12342openalex-snapshot

Canagliflozin is a potential cardioprotective drug but exerts no significant effects on pirarubicin‑induced cardiotoxicity in rats

inferred← citeshttps://doi.org/10.4070/kcj.2007.37.9.408openalex-snapshot

The Cardioprotective Effects of Resveratrol via Anti-Apoptosis in Hypoxic Injury of Myocardial Cells

inferred← citeshttps://doi.org/10.4103/2045-9912.191365openalex-snapshot

Hypoxia therapy--a new hope for the treatment of mitochondrial dysfunctions

inferred← citeshttps://doi.org/10.5385/jksn.2010.17.2.181openalex-snapshot

Neuroprotective Effect of Dizocilpine (MK-801) via Anti-apoptosis on Hypoxic-ischemic Brain Injury in Neonatal Rats

inferred← citeshttps://doi.org/10.7555/jbr.36.20220125openalex-snapshot

The effect of an adaptation to hypoxia on cardiac tolerance to ischemia/reperfusion

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