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Always look on the bright site of Rho: structural implications for a conserved intermolecular interface

https://doi.org/10.1038/sj.embor.7400293
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1016/j.tibs.2003.10.007openalex-snapshot
TPR proteins: the versatile helix
inferredcites →https://doi.org/10.1016/s0014-5793(01)02970-2openalex-snapshot
Structural mimicry of DH domains by Arfaptin suggests a model for the recognition of Rac–GDP by its guanine nucleotide exchange factors
inferredcites →https://doi.org/10.1016/s0014-5793(03)01351-6openalex-snapshot
Comparative functional analysis of the Rac GTPases
inferredcites →https://doi.org/10.1016/s0092-8674(00)80670-4openalex-snapshot
Structure of the Rho Family GTP-Binding Protein Cdc42 in Complex with the Multifunctional Regulator RhoGDI
inferredcites →https://doi.org/10.1016/s0092-8674(03)00315-5openalex-snapshot
Switch-of-Function Mutants Based on Morphology Classification of Ras Superfamily Small GTPases
inferredcites →https://doi.org/10.1016/s0092-8674(04)00003-0openalex-snapshot
Rho and Rac Take Center Stage
inferredcites →https://doi.org/10.1016/s0898-6568(98)00063-1openalex-snapshot
Rho Guanine Dissociation Inhibitors
inferredcites →https://doi.org/10.1016/s0959-440x(98)80038-9openalex-snapshot
GTPase-activating proteins and their complexes
inferredcites →https://doi.org/10.1016/s0960-9822(03)00613-4openalex-snapshot
RhoGDI Is Required for Cdc42-Mediated Cellular Transformation
inferredcites →https://doi.org/10.1016/s0962-8924(02)00004-1openalex-snapshot
Rho GTPase-activating proteins in cell regulation
inferredcites →https://doi.org/10.1016/s0962-8924(03)00037-0openalex-snapshot
Bacterial virulence factors targeting Rho GTPases: parasitism or symbiosis?
inferredcites →https://doi.org/10.1016/s0968-0004(00)01748-5openalex-snapshot
Substrate assisted catalysis – application to G proteins
inferredcites →https://doi.org/10.1016/s0968-0004(01)01974-0openalex-snapshot
The many faces of Ras: recognition of small GTP-binding proteins
inferredcites →https://doi.org/10.1016/s0968-0004(98)01224-9openalex-snapshot
GTPase-activating proteins: helping hands to complement an active site
inferredcites →https://doi.org/10.1016/s1074-5521(02)00112-6openalex-snapshot
MgF3− as a Transition State Analog of Phosphoryl Transfer
inferredcites →https://doi.org/10.1016/s1097-2765(00)00087-3openalex-snapshot
Structure of the TPR Domain of p67phox in Complex with Rac·GTP
inferredcites →https://doi.org/10.1016/s1097-2765(00)00141-6openalex-snapshot
Modulation of Host Signaling by a Bacterial Mimic
inferredcites →https://doi.org/10.1016/s1097-2765(00)80389-5openalex-snapshot
The Structural Basis of Rho Effector Recognition Revealed by the Crystal Structure of Human RhoA Complexed with the Effector Domain of PKN/PRK1
inferredcites →https://doi.org/10.1021/bi010288kopenalex-snapshot
Crystal Structure of the Rac1−RhoGDI Complex Involved in NADPH Oxidase Activation,
inferredcites →https://doi.org/10.1021/bi036026vopenalex-snapshot
Structural Elements, Mechanism, and Evolutionary Convergence of Rho Protein−Guanine Nucleotide Exchange Factor Complexes
inferredcites →https://doi.org/10.1021/bi9821770openalex-snapshot
The Conserved Arginine in Rho-GTPase-Activating Protein Is Essential for Efficient Catalysis but Not for Complex Formation with Rho·GDP and Aluminum Fluoride
inferredcites →https://doi.org/10.1021/bi992646dopenalex-snapshot
Structure of the Complex of Cdc42Hs with a Peptide Derived from P-21 Activated Kinase,
inferredcites →https://doi.org/10.1038/20726openalex-snapshot
Structure of Cdc42 in complex with the GTPase-binding domain of the ‘Wiskott–Aldrich syndrome’ protein
inferredcites →https://doi.org/10.1038/20732openalex-snapshot
Structure of the small G protein Cdc42 bound to the GTPase-binding domain of ACK
inferredcites →https://doi.org/10.1038/35047014openalex-snapshot
Crystal structure of Rac1 in complex with the guanine nucleotide exchange region of Tiam1
inferredcites →https://doi.org/10.1038/35075620openalex-snapshot
The structural basis of Arfaptin-mediated cross-talk between Rac and Arf signalling pathways
inferredcites →https://doi.org/10.1038/39651openalex-snapshot
Structure at 1.65 Å of RhoA and its GTPase-activating protein in complex with a transition-state analogue
inferredcites →https://doi.org/10.1038/4156openalex-snapshot
Structures of Cdc42 bound to the active and catalytically compromised forms of Cdc42GAP
inferredcites →https://doi.org/10.1038/41805openalex-snapshot
Crystal structure of a small G protein in complex with the GTPase-activating protein rhoGAP
inferredcites →https://doi.org/10.1038/72392openalex-snapshot
The Rac-RhoGDI complex and the structural basis for the regulation of Rho proteins by RhoGDI.
inferredcites →https://doi.org/10.1038/75158openalex-snapshot
Structure of Cdc42 bound to the GTPase binding domain of PAK.
inferredcites →https://doi.org/10.1038/83007openalex-snapshot
How the Pseudomonas aeruginosa ExoS toxin downregulates Rac.
inferredcites →https://doi.org/10.1038/85240openalex-snapshot
Rac inserts its way into the immune response
inferredcites →https://doi.org/10.1038/85259openalex-snapshot
Molecular basis for Rac2 regulation of phagocyte NADPH oxidase
inferredcites →https://doi.org/10.1038/nature01148openalex-snapshot
Rho GTPases in cell biology
inferredcites →https://doi.org/10.1038/nsb0997-686openalex-snapshot
Confirmation of the arginine-finger hypothesis for the GAP-stimulated GTP-hydrolysis reaction of Ras
inferredcites →https://doi.org/10.1038/nsb0997-699openalex-snapshot
Crystal structure of RhoA–GDP and its functional implications
inferredcites →https://doi.org/10.1038/nsb796openalex-snapshot
Structural basis for the selective activation of Rho GTPases by Dbl exchange factors
inferredcites →https://doi.org/10.1042/bj20030979openalex-snapshot
An activating mutant of Rac1 that fails to interact with Rho GDP-dissociation inhibitor stimulates membrane ruffling in mammalian cells
inferredcites →https://doi.org/10.1042/bj3480241openalex-snapshot
Rho GTPases and their effector proteins
inferredcites →https://doi.org/10.1074/jbc.273.16.9656openalex-snapshot
Crystal Structure of Human RhoA in a Dominantly Active Form Complexed with a GTP Analogue
inferredcites →https://doi.org/10.1074/jbc.273.26.16210openalex-snapshot
Biochemical Studies of the Mechanism of Action of the Cdc42-GTPase-activating Protein
inferredcites →https://doi.org/10.1074/jbc.m311911200openalex-snapshot
Structural Insights into the Interaction of ROCKI with the Switch Regions of RhoA
inferredcites →https://doi.org/10.1074/jbc.m409551200openalex-snapshot
Models of the Cooperative Mechanism for Rho Effector Recognition
inferredcites →https://doi.org/10.1093/emboj/21.6.1315openalex-snapshot
A crystallographic view of interactions between Dbs and Cdc42: PH domain‐assisted guanine nucleotide exchange
inferredcites →https://doi.org/10.1093/emboj/cdf329openalex-snapshot
Structural basis for the reversible activation of a Rho protein by the bacterial toxin SopE
inferredcites →https://doi.org/10.1093/emboj/cdg110openalex-snapshot
Structure of Cdc42 in a complex with the GTPase‐binding domain of the cell polarity protein, Par6
inferredcites →https://doi.org/10.1107/s090744499900801xopenalex-snapshot
How RhoGDI binds Rho
inferredcites →https://doi.org/10.1126/science.1062023openalex-snapshot
The Guanine Nucleotide-Binding Switch in Three Dimensions
inferredcites →https://doi.org/10.1242/jcs.01118openalex-snapshot
Rho-family GTPases: it's not only Rac and Rho (and I like it)

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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A Targeted Protein Degradation Cell-Based Screening for Intracellular Nanobodies to Assess the Functions of RHOB GTP-Bound Conformation
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ROP/RAC GTP ases
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Anillin: The First Proofreading‐like Scaffold?
inferred← citeshttps://doi.org/10.1002/bip.21601openalex-snapshot
The unique plant RhoGAPs are dimeric and contain a CRIB motif required for affinity and specificity towards cognate small G proteins
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Centralspindlin: At the heart of cytokinesis
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The MyMOMA domain of MYO19 encodes for distinct Miro‐dependent and Miro‐independent mechanisms of interaction with mitochondrial membranes
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Signatures of selection in the three‐spined stickleback along a small‐scale brackish water – freshwater transition zone
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Recurrent RHOA mutations in pediatric B urkitt lymphoma treated according to the NHL‐BFM protocols
inferred← citeshttps://doi.org/10.1007/11560500_9openalex-snapshot
MAPPIS: Multiple 3D Alignment of Protein-Protein Interfaces
inferred← citeshttps://doi.org/10.1007/978-1-0716-0845-6_10openalex-snapshot
Identification of Rho GEF and RhoA Activation by Pull-Down Assays
inferred← citeshttps://doi.org/10.1007/978-1-4419-1111-7_2openalex-snapshot
Rho Proteins in Cancer
inferred← citeshttps://doi.org/10.1007/978-1-4419-6382-6_1openalex-snapshot
Isoprenoid Modifications
inferred← citeshttps://doi.org/10.1007/978-1-4614-7881-2_19-1openalex-snapshot
ROP GTPases and Cell Shape
inferred← citeshttps://doi.org/10.1007/978-1-4939-8612-5_9openalex-snapshot
An In Vitro Kinase Assay to Assess Rac1 Phosphorylation by ERK
inferred← citeshttps://doi.org/10.1007/978-1-61779-442-1_3openalex-snapshot
Biochemical Assays to Characterize Rho GTPases
inferred← citeshttps://doi.org/10.1007/978-3-030-35582-1_6openalex-snapshot
Rho-ROCK Signaling in Normal Physiology and as a Key Player in Shaping the Tumor Microenvironment
inferred← citeshttps://doi.org/10.1007/978-3-540-30219-3_17openalex-snapshot
Protein-Protein Interfaces: Recognition of Similar Spatial and Chemical Organizations
inferred← citeshttps://doi.org/10.1007/978-3-642-03524-1_3openalex-snapshot
Structure and Function of ROPs and their GEFs
inferred← citeshttps://doi.org/10.1007/978-3-7091-1806-1_14openalex-snapshot
Classical Rho Proteins: Biochemistry of Molecular Switch Function and Regulation
inferred← citeshttps://doi.org/10.1007/978-94-017-9732-0_12openalex-snapshot
The Kinesin-6 Members MKLP1, MKLP2 and MPP1
inferred← citeshttps://doi.org/10.1007/s00018-005-5136-xopenalex-snapshot
GTPase activating proteins: structural and functional insights 18 years after discovery
inferred← citeshttps://doi.org/10.1007/s00018-006-6197-1openalex-snapshot
ROPs in the spotlight of plant signal transduction
inferred← citeshttps://doi.org/10.1007/s00210-006-0113-yopenalex-snapshot
C3 exoenzymes, novel insights into structure and action of Rho-ADP-ribosylating toxins
inferred← citeshttps://doi.org/10.1007/s00344-007-9022-7openalex-snapshot
Small GTP-binding Proteins and their Functions in Plants
inferred← citeshttps://doi.org/10.1007/s12026-020-09168-yopenalex-snapshot
Progressive decline of T and B cell numbers and function in a patient with CDC42 deficiency
inferred← citeshttps://doi.org/10.1016/j.advenzreg.2009.01.004openalex-snapshot
Regulatory links between PLC enzymes and Ras superfamily GTPases: Signalling via PLCɛ
inferred← citeshttps://doi.org/10.1016/j.ajhg.2017.12.015openalex-snapshot
Functional Dysregulation of CDC42 Causes Diverse Developmental Phenotypes
inferred← citeshttps://doi.org/10.1016/j.bbadis.2024.167520openalex-snapshot
Pathophysiological significance of the p.E31G variant in RAC1 responsible for a neurodevelopmental disorder with microcephaly
inferred← citeshttps://doi.org/10.1016/j.bbrc.2013.04.012openalex-snapshot
Interaction characteristics of Plexin-B1 with Rho family proteins
inferred← citeshttps://doi.org/10.1016/j.bcp.2022.115321openalex-snapshot
A current overview of RhoA, RhoB, and RhoC functions in vascular biology and pathology
inferred← citeshttps://doi.org/10.1016/j.braindev.2026.104503openalex-snapshot
A lipidation inhibitor rescues impaired neurite outgrowth caused by the CDC42 mutation associated with Takenouchi-Kosaki syndrome in Neuro2A cells
inferred← citeshttps://doi.org/10.1016/j.cell.2006.06.056openalex-snapshot
Yersinia Virulence Depends on Mimicry of Host Rho-Family Nucleotide Dissociation Inhibitors
inferred← citeshttps://doi.org/10.1016/j.devcel.2019.04.031openalex-snapshot
Anillin Promotes Cell Contractility by Cyclic Resetting of RhoA Residence Kinetics
inferred← citeshttps://doi.org/10.1016/j.devcel.2019.05.042openalex-snapshot
Anillin Puts RhoA in Touch with PIP2
inferred← citeshttps://doi.org/10.1016/j.ejcb.2010.11.009openalex-snapshot
Rho proteins of plants – Functional cycle and regulation of cytoskeletal dynamics
inferred← citeshttps://doi.org/10.1016/j.ijbiomac.2021.04.022openalex-snapshot
Tumor suppressor gene DLC1: Its modifications, interactive molecules, and potential prospects for clinical cancer application
inferred← citeshttps://doi.org/10.1016/j.jbc.2025.108346openalex-snapshot
A p.N92K variant of the GTPase RAC3 disrupts cortical neuron migration and axon elongation
inferred← citeshttps://doi.org/10.1016/j.jbc.2026.111260openalex-snapshot
An evolutionarily conserved salt bridge stabilizes the active site for GTP hydrolysis in Rho GTPases
inferred← citeshttps://doi.org/10.1016/j.jbc.2026.113402openalex-snapshot
Hearing loss associated with CDC42 in mice and humans (Takenouchi–Kosaki syndrome): CDC42 and RHOQ synergistically function in cochlear hair cells
inferred← citeshttps://doi.org/10.1016/j.jmb.2007.02.060openalex-snapshot
The DH and PH Domains of Trio Coordinately Engage Rho GTPases for their Efficient Activation
inferred← citeshttps://doi.org/10.1016/j.jmb.2008.01.081openalex-snapshot
Compensatory and Long-Range Changes in Picosecond–Nanosecond Main-Chain Dynamics upon Complex Formation: 15N Relaxation Analysis of the Free and Bound States of the Ubiquitin-like Domain of Human Plexin-B1 and the Small GTPase Rac1
inferred← citeshttps://doi.org/10.1016/j.jmb.2008.03.043openalex-snapshot
Prediction of Interacting Single-Stranded RNA Bases by Protein-Binding Patterns
inferred← citeshttps://doi.org/10.1016/j.jmb.2009.01.056openalex-snapshot
Characterisation of the Nucleotide Exchange Factor ITSN1L: Evidence for a Kinetic Discrimination of GEF-Stimulated Nucleotide Release from Cdc42
inferred← citeshttps://doi.org/10.1016/j.molcel.2005.08.036openalex-snapshot
An Electrostatic Steering Mechanism of Cdc42 Recognition by Wiskott-Aldrich Syndrome Proteins
inferred← citeshttps://doi.org/10.1016/j.molcel.2009.02.023openalex-snapshot
Structural Insights into Formation of an Active Signaling Complex between Rac and Phospholipase C Gamma 2
inferred← citeshttps://doi.org/10.1016/j.molcel.2009.03.008openalex-snapshot
The Fic Domain: Regulation of Cell Signaling by Adenylylation
inferred← citeshttps://doi.org/10.1016/j.phytochem.2006.08.011openalex-snapshot
The crystal structure of Arabidopsis thaliana RAC7/ROP9: The first RAS superfamily GTPase from the plant kingdom
inferred← citeshttps://doi.org/10.1016/j.plaphy.2007.12.008openalex-snapshot
Structure and function of Rho-type molecular switches in plants
inferred← citeshttps://doi.org/10.1016/j.tcb.2005.10.006openalex-snapshot
Cytokinesis: welcome to the Rho zone
inferred← citeshttps://doi.org/10.1016/j.tcb.2006.10.007openalex-snapshot
Phospholipase C epsilon: linking second messengers and small GTPases
inferred← citeshttps://doi.org/10.1016/j.tibs.2010.08.003openalex-snapshot
PLC regulation: emerging pictures for molecular mechanisms
inferred← citeshttps://doi.org/10.1016/j.tim.2008.01.011openalex-snapshot
Structure and mode of action of clostridial glucosylating toxins: the ABCD model
inferred← citeshttps://doi.org/10.1016/j.ydbio.2013.08.024openalex-snapshot
Caenorhabditis elegans anillin (ani-1) regulates neuroblast cytokinesis and epidermal morphogenesis during embryonic development
inferred← citeshttps://doi.org/10.1016/j.ydbio.2025.12.010openalex-snapshot
The RhoA signaling pathway is required for planarian intestinal regeneration
inferred← citeshttps://doi.org/10.1016/s0076-6879(06)06001-0openalex-snapshot
Purification and Biochemical Properties of Rac1, 2, 3 and the Splice Variant Rac1b
inferred← citeshttps://doi.org/10.1021/acs.jcim.5c02116openalex-snapshot
Teeter-Totter-Like Redistribution of Switch I: Integrating Simulation and Experiment to Uncover the Molecular Basis of Oncogenic Rac1Mutations
inferred← citeshttps://doi.org/10.1021/bi201211vopenalex-snapshot
Structural Coupling between the Rho-Insert Domain of Cdc42 and the Geranylgeranyl Binding Site of RhoGDI
inferred← citeshttps://doi.org/10.1021/bi8017448openalex-snapshot
Probing the Recognition Properties of the Antiparallel Coiled Coil Motif from PKN by Protein Grafting
inferred← citeshttps://doi.org/10.1038/ncomms8807openalex-snapshot
Tyrosine glycosylation of Rho by Yersinia toxin impairs blastomere cell behaviour in zebrafish embryos
inferred← citeshttps://doi.org/10.1038/nsmb1175openalex-snapshot
Crystal structure of Rac1 bound to its effector phospholipase C-β2
inferred← citeshttps://doi.org/10.1038/s10038-019-0656-7openalex-snapshot
A de novo variant in RAC3 causes severe global developmental delay and a middle interhemispheric variant of holoprosencephaly
inferred← citeshttps://doi.org/10.1038/s41417-025-00965-xopenalex-snapshot
New insights into the classification of the RAC1 P29S hotspot mutation in melanoma as an oncogene
inferred← citeshttps://doi.org/10.1038/s41467-020-20255-4openalex-snapshot
A RAC-GEF network critical for early intestinal tumourigenesis
inferred← citeshttps://doi.org/10.1038/s41467-022-32541-4openalex-snapshot
SH3 domain regulation of RhoGAP activity: Crosstalk between p120RasGAP and DLC1 RhoGAP
inferred← citeshttps://doi.org/10.1038/s41598-021-97478-yopenalex-snapshot
Macrothrombocytopenia of Takenouchi-Kosaki syndrome is ameliorated by CDC42 specific- and lipidation inhibitors in MEG-01 cells
inferred← citeshttps://doi.org/10.1038/s41598-023-36381-0openalex-snapshot
A missense variant at the RAC1-PAK1 binding site of RAC1 inactivates downstream signaling in VACTERL association
inferred← citeshttps://doi.org/10.1038/sj.onc.1209274openalex-snapshot
BNIP-Sα induces cell rounding and apoptosis by displacing p50RhoGAP and facilitating RhoA activation via its unique motifs in the BNIP-2 and Cdc42GAP homology domain
inferred← citeshttps://doi.org/10.1038/srep14437openalex-snapshot
Coronin7 regulates WASP and SCAR through CRIB mediated interaction with Rac proteins
inferred← citeshttps://doi.org/10.1038/srep45829openalex-snapshot
Nucleotide Dependent Switching in Rho GTPase: Conformational Heterogeneity and Competing Molecular Interactions
inferred← citeshttps://doi.org/10.1042/bj20050104openalex-snapshot
RhoGDI: multiple functions in the regulation of Rho family GTPase activities
inferred← citeshttps://doi.org/10.1042/bj20081535openalex-snapshot
A BAR domain-mediated autoinhibitory mechanism for RhoGAPs of the GRAF family
inferred← citeshttps://doi.org/10.1042/bst20110625openalex-snapshot
The small Rho GTPase Rif and actin cytoskeletal remodelling
inferred← citeshttps://doi.org/10.1073/pnas.1804740115openalex-snapshot
GEF mechanism revealed by the structure of SmgGDS-558 and farnesylated RhoA complex and its implication for a chaperone mechanism
inferred← citeshttps://doi.org/10.1073/pnas.2023245118openalex-snapshot
Structural basis for selective AMPylation of Rac-subfamily GTPases by Bartonella effector protein 1 (Bep1)
inferred← citeshttps://doi.org/10.1073/pnas.2534531123openalex-snapshot
RHOA controls oncogenic B cell receptor signaling in aggressive lymphoma
inferred← citeshttps://doi.org/10.1074/jbc.m111.226431openalex-snapshot
Mechanistic Insights into Specificity, Activity, and Regulatory Elements of the Regulator of G-protein Signaling (RGS)-containing Rho-specific Guanine Nucleotide Exchange Factors (GEFs) p115, PDZ-RhoGEF (PRG), and Leukemia-associated RhoGEF (LARG)
inferred← citeshttps://doi.org/10.1074/jbc.m112.363598openalex-snapshot
A Salmonella typhimurium-translocated Glycerophospholipid:Cholesterol Acyltransferase Promotes Virulence by Binding to the RhoA Protein Switch Regions
inferred← citeshttps://doi.org/10.1074/jbc.m112.429746openalex-snapshot
Deciphering the Molecular and Functional Basis of Dbl Family Proteins
inferred← citeshttps://doi.org/10.1074/jbc.m113.527655openalex-snapshot
Functional Cross-talk between Ras and Rho Pathways
inferred← citeshttps://doi.org/10.1074/jbc.m116.736140openalex-snapshot
Structural Basis for the Specific Recognition of RhoA by the Dual GTPase-activating Protein ARAP3
inferred← citeshttps://doi.org/10.1074/jbc.m116.736967openalex-snapshot
Deciphering the Molecular and Functional Basis of RHOGAP Family Proteins
inferred← citeshttps://doi.org/10.1074/jbc.m116.752121openalex-snapshot
IQGAP1 Interaction with RHO Family Proteins Revisited
inferred← citeshttps://doi.org/10.1074/jbc.m409551200openalex-snapshot
Models of the Cooperative Mechanism for Rho Effector Recognition
inferred← citeshttps://doi.org/10.1074/jbc.m600863200openalex-snapshot
Exchange of a Single Amino Acid Switches the Substrate Properties of RhoA and RhoD toward Glucosylating and Transglutaminating Toxins
inferred← citeshttps://doi.org/10.1074/jbc.m803316200openalex-snapshot
Rac Regulates Its Effector Phospholipase Cγ2 through Interaction with a Split Pleckstrin Homology Domain
inferred← citeshttps://doi.org/10.1074/jbc.m805634200openalex-snapshot
Specificity of Interactions between mDia Isoforms and Rho Proteins
inferred← citeshttps://doi.org/10.1074/jbc.ra117.001596openalex-snapshot
Unraveling the molecular mechanism of interactions of the Rho GTPases Cdc42 and Rac1 with the scaffolding protein IQGAP2
inferred← citeshttps://doi.org/10.1080/21541248.2017.1321169openalex-snapshot
New model for the interaction of IQGAP1 with CDC42 and RAC1
inferred← citeshttps://doi.org/10.1080/21541248.2022.2111945openalex-snapshot
Quantitation of RhoA activation: differential binding to downstream effectors
inferred← citeshttps://doi.org/10.1083/jcb.201103008openalex-snapshot
The Ras protein superfamily: Evolutionary tree and role of conserved amino acids
inferred← citeshttps://doi.org/10.1083/jcb.202405182openalex-snapshot
Anillin mediates unilateral furrowing during cytokinesis by limiting RhoA binding to its effectors
inferred← citeshttps://doi.org/10.1084/jem.20190147openalex-snapshot
A novel disorder involving dyshematopoiesis, inflammation, and HLH due to aberrant CDC42 function
inferred← citeshttps://doi.org/10.1091/mbc.e06-04-0294openalex-snapshot
EphA4 Signaling Regulates Blastomere Adhesion in the Xenopus Embryo by Recruiting Pak1 to Suppress Cdc42 Function
inferred← citeshttps://doi.org/10.1093/brain/awac106openalex-snapshot
Variant-specific changes in RAC3 function disrupt corticogenesis in neurodevelopmental phenotypes
inferred← citeshttps://doi.org/10.1093/jb/mvt005openalex-snapshot
The role of NADRIN, a Rho GTPase-activating protein, in the morphological differentiation of astrocytes
inferred← citeshttps://doi.org/10.1093/jxb/erv057openalex-snapshot
Protein lipid modifications and the regulation of ROP GTPase function
inferred← citeshttps://doi.org/10.1099/jmm.0.47742-0openalex-snapshot
Processing of Clostridium difficile toxins
inferred← citeshttps://doi.org/10.1101/2021.01.08.425872openalex-snapshot
Microtubule-associated ROP interactors both delimit and transduce ROP signaling and regulate microtubule dynamics
inferred← citeshttps://doi.org/10.1101/2021.08.28.458042openalex-snapshot
Tip growth in the brown alga Ectocarpus is controlled by a RHO-GAP-BAR domain protein independently from F-actin organisation
inferred← citeshttps://doi.org/10.1101/282756openalex-snapshot
Scaffolding of RhoA contractile signaling by anillin: a regulatory analogue of kinetic proofreading
inferred← citeshttps://doi.org/10.1103/physreve.111.024403openalex-snapshot
Advecting scaffolds: Controlling the remodeling of actomyosin with anillin
inferred← citeshttps://doi.org/10.1111/cmi.12420openalex-snapshot
Salmonellamodulation of the phagosome membrane, role of SseJ
inferred← citeshttps://doi.org/10.1111/febs.70660openalex-snapshot
Structural insight of the EhFP10 –Rho2–Myosin‐ IB tricomplex reveals a novel signaling module for cytoskeleton remodeling in Entamoeba histolytica
inferred← citeshttps://doi.org/10.1126/sciadv.aax1595openalex-snapshot
Decreased conformational stability in the oncogenic N92I mutant of Ras-related C3 botulinum toxin substrate 1
inferred← citeshttps://doi.org/10.1128/iai.01250-09openalex-snapshot
Bacterial Guanine Nucleotide Exchange Factors SopE-Like and WxxxE Effectors
inferred← citeshttps://doi.org/10.1128/mbio.03018-24openalex-snapshot
VopX, a novel Vibrio cholerae T3SS effector, modulates host actin dynamics
inferred← citeshttps://doi.org/10.1136/jmedgenet-2022-108483openalex-snapshot
Gain-of-function p.F28S variant in RAC3 disrupts neuronal differentiation, migration and axonogenesis during cortical development, leading to neurodevelopmental disorder
inferred← citeshttps://doi.org/10.1161/hypertensionaha.111.189761openalex-snapshot
Tumor Necrosis Factor α Decreases Nitric Oxide Synthase Type 3 Expression Primarily via Rho/Rho Kinase in the Thick Ascending Limb
inferred← citeshttps://doi.org/10.1186/s12935-024-03519-7openalex-snapshot
RhoA-ROCK2 signaling possesses complex pathophysiological functions in cancer progression and shows promising therapeutic potential
inferred← citeshttps://doi.org/10.1242/dev.200811openalex-snapshot
Microtubule-associated ROP interactors affect microtubule dynamics and modulate cell wall patterning and root hair growth
inferred← citeshttps://doi.org/10.1242/jcs.021774openalex-snapshot
BNIP2 extra long inhibits RhoA and cellular transformation by Lbc RhoGEF via its BCH domain
inferred← citeshttps://doi.org/10.1371/journal.pbio.1002097openalex-snapshot
Spontaneous Cdc42 Polarization Independent of GDI-Mediated Extraction and Actin-Based Trafficking
inferred← citeshttps://doi.org/10.1371/journal.pone.0069315openalex-snapshot
RhoA Is Essential for Maintaining Normal Megakaryocyte Ploidy and Platelet Generation
inferred← citeshttps://doi.org/10.1371/journal.pone.0102425openalex-snapshot
Liposome Reconstitution and Modulation of Recombinant Prenylated Human Rac1 by GEFs, GDI1 and Pak1
inferred← citeshttps://doi.org/10.1371/journal.pone.0147103openalex-snapshot
Phosphorylation and Activation of RhoA by ERK in Response to Epidermal Growth Factor Stimulation
inferred← citeshttps://doi.org/10.1371/journal.pone.0167145openalex-snapshot
The RAS-Effector Interface: Isoform-Specific Differences in the Effector Binding Regions
inferred← citeshttps://doi.org/10.1371/journal.pone.0172613openalex-snapshot
RhoA promotes epidermal stem cell proliferation via PKN1-cyclin D1 signaling
inferred← citeshttps://doi.org/10.1515/bc.2005.127openalex-snapshot
Monitoring the real-time kinetics of the hydrolysis reaction of guanine nucleotide-binding proteins
inferred← citeshttps://doi.org/10.1515/bc.2007.008openalex-snapshot
Asef is a Cdc42-specific guanine nucleotide exchange factor
inferred← citeshttps://doi.org/10.1515/hsz-2013-0181openalex-snapshot
Rho-kinase: regulation, (dys)function, and inhibition
inferred← citeshttps://doi.org/10.17615/kmq6-qg97openalex-snapshot
Atypical Guanine Nucleotide Exchange Factors for Rho Family GTPases: DOCK9 Activation of Cdc42 and SmgGDS activation of RhoA
inferred← citeshttps://doi.org/10.17760/d20286915openalex-snapshot
Structural relationships between members of the Ras superfamily of small GTPases and their roles in functional diversity
inferred← citeshttps://doi.org/10.18388/abp.2006_3322openalex-snapshot
Novel peptide recognized by RhoA GTPase.
inferred← citeshttps://doi.org/10.18632/oncotarget.10188openalex-snapshot
The anticancer phytochemical rocaglamide inhibits Rho GTPase activity and cancer cell migration
inferred← citeshttps://doi.org/10.21203/rs.3.rs-2272084/v1openalex-snapshot
Genome-wide identification of small GTPase gene family members in Lentinula edodes and their expression profiling under adversity stress
inferred← citeshttps://doi.org/10.21203/rs.3.rs-8784410/v1openalex-snapshot
Structural and functional insights into the p160 Rho-associated coiled-coil-containing protein kinase ROCK
inferred← citeshttps://doi.org/10.2174/0113892037392325250706122413openalex-snapshot
Targeting Cdc42: Novel Approaches in Cardiovascular Disorders
inferred← citeshttps://doi.org/10.2337/db26-0029openalex-snapshot
A Selective Cullin 3 RING E3 Ligase Inhibitor Attenuates Hyperglycemia via Dual Insulin Sensitizing and Insulinotropic Action
inferred← citeshttps://doi.org/10.31083/fbl44589openalex-snapshot
Rho GTPase and Rho Kinase Signaling in Tissue Contractility and Intraocular Pressure Regulation
inferred← citeshttps://doi.org/10.3324/haematol.2018.210286openalex-snapshot
ARHGEF12 regulates erythropoiesis and is involved in erythroid regeneration after chemotherapy in acute lymphoblastic leukemia patients
inferred← citeshttps://doi.org/10.3389/fmolb.2021.643728openalex-snapshot
Structural Design and Analysis of the RHOA-ARHGEF1 Binding Mode: Challenges and Applications for Protein-Protein Interface Prediction
inferred← citeshttps://doi.org/10.3390/biology11111627openalex-snapshot
Crystal Structure of Schizosaccharomyces pombe Rho1 Reveals Its Evolutionary Relationship with Other Rho GTPases
inferred← citeshttps://doi.org/10.3390/cancers13215386openalex-snapshot
RHO GTPase-Related Long Noncoding RNAs in Human Cancers
inferred← citeshttps://doi.org/10.3390/cells10071592openalex-snapshot
Regulation of the Actin Cytoskeleton via Rho GTPase Signalling in Dictyostelium and Mammalian Cells: A Parallel Slalom
inferred← citeshttps://doi.org/10.3390/cells10071831openalex-snapshot
The RHO Family GTPases: Mechanisms of Regulation and Signaling
inferred← citeshttps://doi.org/10.3390/cells10123395openalex-snapshot
Pathophysiological Mechanisms in Neurodevelopmental Disorders Caused by Rac GTPases Dysregulation: What’s behind Neuro-RACopathies
inferred← citeshttps://doi.org/10.3390/cells11040696openalex-snapshot
Impaired Function of PLEKHG2, a Rho-Guanine Nucleotide-Exchange Factor, Disrupts Corticogenesis in Neurodevelopmental Phenotypes
inferred← citeshttps://doi.org/10.3390/cells13232032openalex-snapshot
The p.R66W Variant in RAC3 Causes Severe Fetopathy Through Variant-Specific Mechanisms
inferred← citeshttps://doi.org/10.3390/cimb46040219openalex-snapshot
Rhoa/ROCK, mTOR and Secretome-Based Treatments for Ischemic Stroke: New Perspectives
inferred← citeshttps://doi.org/10.3390/genes12020294openalex-snapshot
Pancytopenia, Recurrent Infection, Poor Wound Healing, Heterotopia of the Brain Probably Associated with A Candidate Novel de Novo CDC42 Gene Defect: Expanding the Molecular and Phenotypic Spectrum
inferred← citeshttps://doi.org/10.3390/ijms151018253openalex-snapshot
Molecular Mechanisms of Host Cytoskeletal Rearrangements by Shigella Invasins
inferred← citeshttps://doi.org/10.3390/ijms222212493openalex-snapshot
Electrostatic Forces Mediate the Specificity of RHO GTPase-GDI Interactions
inferred← citeshttps://doi.org/10.3390/ijms222212596openalex-snapshot
Selectivity Determinants of RHO GTPase Binding to IQGAPs
inferred← citeshttps://doi.org/10.3390/ijms23168842openalex-snapshot
CDC42-IQGAP Interactions Scrutinized: New Insights into the Binding Properties of the GAP-Related Domain
inferred← citeshttps://doi.org/10.3390/ijms232213888openalex-snapshot
Fission Yeast Rho1p-GEFs: From Polarity and Cell Wall Synthesis to Genome Stability
inferred← citeshttps://doi.org/10.3390/molecules28072976openalex-snapshot
Rac1: A Regulator of Cell Migration and a Potential Target for Cancer Therapy
inferred← citeshttps://doi.org/10.3410/f.736800321.793569613openalex-snapshot
Faculty Opinions recommendation of Extraction of active RhoGTPases by RhoGDI regulates spatiotemporal patterning of RhoGTPases.
inferred← citeshttps://doi.org/10.4161/21541248.2014.968004openalex-snapshot
Toward understanding RhoGTPase specificity: structure, function and local activation
inferred← citeshttps://doi.org/10.48496/eacr-r666openalex-snapshot
A Structural Basis for Host Cytoskeletal Disruption and Virulence by Yersinia Protein Kinase A
inferred← citeshttps://doi.org/10.53846/goediss-448openalex-snapshot
Rho GTPases and their regulators in cell polarity of the filamentous ascomycete Neurospora crassa
inferred← citeshttps://doi.org/10.5772/intechopen.75913openalex-snapshot
The Function of Fission Yeast Rho1-GEFs in the Control of Cell Growth and Division
inferred← citeshttps://doi.org/10.64898/2026.05.08.723678openalex-snapshot
Specificity Profiling of the RhoGEF Domain of FP10 with Rho GTPases Involved in Cytoskeleton Remodeling from Entamoeba histolytica
inferred← citeshttps://doi.org/10.70675/4ca0710fzd709z4d42zbf43z2c0dea765e4dopenalex-snapshot
Développement de méthodologies innovantes pour la caractérisation d’interfaces protéine-protéine et la conception d’inhibiteurs spécifiques : exploration de l’interface protéique de RhoA /ArhGEF1
inferred← citeshttps://doi.org/10.70675/b320c382zf596z4f84z8ad8z14eb0182a31dopenalex-snapshot
Conception de nano-anticorps conformationnels comme nouveaux outils d'étude de l'activité des GTPases de la sous-famille RHOA
inferred← citeshttps://doi.org/10.7554/elife.14222openalex-snapshot
Murine Fam65b forms ring-like structures at the base of stereocilia critical for mechanosensory hair cell function
inferred← citeshttps://doi.org/10.7554/elife.50471openalex-snapshot
Extraction of active RhoGTPases by RhoGDI regulates spatiotemporal patterning of RhoGTPases
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