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Of cascades and perfect storms: the immunopathogenesis of dengue haemorrhagic fever‐dengue shock syndrome (DHF/DSS)

https://doi.org/10.1038/sj.icb.7100008

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What this work says

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Antibodies from patients with dengue viral infection mediate cellular cytotoxicity

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CORRELATION OF SERUM LEVELS OF MACROPHAGE MIGRATION INHIBITORY FACTOR WITH DISEASE SEVERITY AND CLINICAL OUTCOME IN DENGUE PATIENTS

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Different phenotypes of non‐classical monocytes associated with systemic inflammation, endothelial alteration and hepatic compromise in patients with dengue

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Denguevirus-specific suppressor T cells: current perspectives

inferred← citeshttps://doi.org/10.1111/j.1600-065x.2008.00736.xopenalex-snapshot

Crosstalk between components of the innate immune system: promoting anti‐microbial defenses and avoiding immunopathologies

inferred← citeshttps://doi.org/10.1111/j.1749-6632.2009.05050.xopenalex-snapshot

A Re‐evaluation of the Mechanisms Leading to Dengue Hemorrhagic Fever

inferred← citeshttps://doi.org/10.1111/risa.15102openalex-snapshot

Delineating dengue risk zones in Jaipur: An interdisciplinary approach to inform public health strategies

inferred← citeshttps://doi.org/10.1128/9781555815493.ch13openalex-snapshot

Antiviral Treatment of Flaviviruses

inferred← citeshttps://doi.org/10.1128/9781555815981.ch52openalex-snapshot

Arthropod?Borne Flaviviruses

inferred← citeshttps://doi.org/10.1128/9781555817411.ch15openalex-snapshot

Dengue Antibody-Dependent Enhancement: Knowns and Unknowns

inferred← citeshttps://doi.org/10.1128/9781555819439.ch53openalex-snapshot

Arthropod-Borne Flaviviruses

inferred← citeshttps://doi.org/10.1128/jvi.00365-14openalex-snapshot

Inhibition of Dengue Virus Replication by a Class of Small-Molecule Compounds That Antagonize Dopamine Receptor D4 and Downstream Mitogen-Activated Protein Kinase Signaling

inferred← citeshttps://doi.org/10.1128/jvi.00746-23openalex-snapshot

Functional and transcriptional heterogeneity within the massively expanding HLADR + CD38 + CD8 T cell population in acute febrile dengue patients

inferred← citeshttps://doi.org/10.1128/jvi.00956-12openalex-snapshot

Interferon Response Factors 3 and 7 Protect against Chikungunya Virus Hemorrhagic Fever and Shock

inferred← citeshttps://doi.org/10.1128/jvi.01915-10openalex-snapshot

Dengue Virus Type 3 Isolated from a Fatal Case with Visceral Complications Induces Enhanced Proinflammatory Responses and Apoptosis of Human Dendritic Cells

inferred← citeshttps://doi.org/10.1128/jvi.02181-17openalex-snapshot

Human T Lymphocytes Are Permissive for Dengue Virus Replication

inferred← citeshttps://doi.org/10.1128/jvi.02484-07openalex-snapshot

Role of Dendritic Cells in Antibody-Dependent Enhancement of Dengue Virus Infection

inferred← citeshttps://doi.org/10.1128/microbiolspec.aid-0022-2014openalex-snapshot

Dengue Antibody-Dependent Enhancement: Knowns and Unknowns

inferred← citeshttps://doi.org/10.1146/annurev-virology-101416-041848openalex-snapshot

The Good, the Bad, and the Shocking: The Multiple Roles of Dengue Virus Nonstructural Protein 1 in Protection and Pathogenesis

inferred← citeshttps://doi.org/10.1155/2011/370872openalex-snapshot

Modulation of Cytokine and Cytokine Receptor/Antagonist by Treatment with Doxycycline and Tetracycline in Patients with Dengue Fever

inferred← citeshttps://doi.org/10.1155/2015/321873openalex-snapshot

Epidemiological Scenario of Dengue in Brazil

inferred← citeshttps://doi.org/10.1155/2016/1016840openalex-snapshot

Vitamin D-Regulated MicroRNAs: Are They Protective Factors against Dengue Virus Infection?

inferred← citeshttps://doi.org/10.1155/2017/7463489openalex-snapshot

Serum Ferritin: A Backstage Weapon in Diagnosis of Dengue Fever

inferred← citeshttps://doi.org/10.1155/2021/4173303openalex-snapshot

Vitamin D Deficiency in Dengue Hemorrhagic Fever and Dengue Shock Syndrome among Sri Lankan Children: A Case-Control Study

inferred← citeshttps://doi.org/10.1172/jci57682openalex-snapshot

Activation of MDL-1 (CLEC5A) on immature myeloid cells triggers lethal shock in mice

inferred← citeshttps://doi.org/10.1182/blood-2013-05-504449openalex-snapshot

Platelets mediate increased endothelium permeability in dengue through NLRP3-inflammasome activation

inferred← citeshttps://doi.org/10.1186/1423-0127-20-40openalex-snapshot

An emerging role for the anti-inflammatory cytokine interleukin-10 in dengue virus infection

inferred← citeshttps://doi.org/10.1186/1471-2148-13-213openalex-snapshot

Dengue virus type 1 clade replacement in recurring homotypic outbreaks

inferred← citeshttps://doi.org/10.1186/1471-2172-11-47openalex-snapshot

Bystander T cells in human immune responses to dengue antigens

inferred← citeshttps://doi.org/10.1186/1471-2334-11-18openalex-snapshot

Possible impact of rising sea levels on vector-borne infectious diseases

inferred← citeshttps://doi.org/10.1186/1471-2334-12-340openalex-snapshot

Induction of IFNα or IL-12 depends on differentiation of THP-1 cells in dengue infections without and with antibody enhancement

inferred← citeshttps://doi.org/10.1186/1471-2334-13-387openalex-snapshot

Detection of dengue viruses using reverse transcription-loop-mediated isothermal amplification

inferred← citeshttps://doi.org/10.1186/1471-2334-8-86openalex-snapshot

Multiplex cytokine profile from dengue patients: MIP-1beta and IFN-gamma as predictive factors for severity

inferred← citeshttps://doi.org/10.1186/1743-422x-10-267openalex-snapshot

Nitric oxide synthase expression correlates with death in an experimental mouse model of dengue with CNS involvement

inferred← citeshttps://doi.org/10.1186/1743-422x-5-165openalex-snapshot

Molecular profiling of T-helper immune genes during dengue virus infection

inferred← citeshttps://doi.org/10.1186/1743-422x-6-49openalex-snapshot

Profile of time-dependent VEGF upregulation in human pulmonary endothelial cells, HPMEC-ST1.6R infected with DENV-1, -2, -3, and -4 viruses

inferred← citeshttps://doi.org/10.1186/s12906-019-2438-3openalex-snapshot

Effect of freeze-dried Carica papaya leaf juice on inflammatory cytokines production during dengue virus infection in AG129 mice

inferred← citeshttps://doi.org/10.1186/s12929-015-0191-6openalex-snapshot

Biomarkers of severe dengue disease – a review

inferred← citeshttps://doi.org/10.1186/s12952-014-0020-6openalex-snapshot

The high-affinity human IgG receptor Fc gamma receptor I (FcγRI) is not associated with vascular leakage of dengue

inferred← citeshttps://doi.org/10.1186/s12974-018-1325-zopenalex-snapshot

New insights into meningitic Escherichia coli infection of brain microvascular endothelial cells from quantitative proteomics analysis

inferred← citeshttps://doi.org/10.1186/s12985-016-0548-9openalex-snapshot

Isolation of dengue virus serotype 4 genotype II from a patient with high viral load and a mixed Th1/Th17 inflammatory cytokine profile in South Brazil

inferred← citeshttps://doi.org/10.1186/s12985-025-02745-3openalex-snapshot

Investigating how dengue virus-induced metabolic changes affect the host immune response and how to develop Immunomodulatory strategies

inferred← citeshttps://doi.org/10.1186/s40249-016-0172-3openalex-snapshot

A community-based prospective cohort study of dengue viral infection in Malaysia: the study protocol

inferred← citeshttps://doi.org/10.1186/s40249-021-00837-0openalex-snapshot

Epidemiology of dengue virus infections in Nepal, 2006–2019

inferred← citeshttps://doi.org/10.1186/s43066-022-00233-9openalex-snapshot

A perfect storm: acute portal vein thrombosis in a patient with severe dengue and hemorrhagic manifestations—a case report

inferred← citeshttps://doi.org/10.1242/bio.201410322openalex-snapshot

Macrophage migration inhibitory factor induces vascular leakage via autophagy

inferred← citeshttps://doi.org/10.1258/ebm.2011.010339openalex-snapshot

Molecular mimicry between virus and host and its implications for dengue disease pathogenesis

inferred← citeshttps://doi.org/10.12688/f1000research.7024.1openalex-snapshot

Pathogenesis of Dengue: Dawn of a New Era

inferred← citeshttps://doi.org/10.13028/gp7w-2589openalex-snapshot

Transcriptional Regulation of the Interleukin-8 Promoter by Multiple Dengue Viral Proteins: A Dissertation

inferred← citeshttps://doi.org/10.1371/journal.pntd.0000304openalex-snapshot

Protective and Enhancing HLA Alleles, HLA-DRB1*0901 and HLA-A*24, for Severe Forms of Dengue Virus Infection, Dengue Hemorrhagic Fever and Dengue Shock Syndrome

inferred← citeshttps://doi.org/10.1371/journal.pntd.0000710openalex-snapshot

Gene Expression Patterns of Dengue Virus-Infected Children from Nicaragua Reveal a Distinct Signature of Increased Metabolism

inferred← citeshttps://doi.org/10.1371/journal.pntd.0000934openalex-snapshot

DC-SIGN (CD209) Promoter −336 A/G Polymorphism Is Associated with Dengue Hemorrhagic Fever and Correlated to DC-SIGN Expression and Immune Augmentation

inferred← citeshttps://doi.org/10.1371/journal.pntd.0002060openalex-snapshot

Differential Expression of Toll-like Receptors in Dendritic Cells of Patients with Dengue during Early and Late Acute Phases of the Disease

inferred← citeshttps://doi.org/10.1371/journal.pntd.0002257openalex-snapshot

Dengue Virus Activates Membrane TRAIL Relocalization and IFN-α Production by Human Plasmacytoid Dendritic Cells In Vitro and In Vivo

inferred← citeshttps://doi.org/10.1371/journal.pntd.0002497openalex-snapshot

Identification of Conserved and HLA Promiscuous DENV3 T-Cell Epitopes

inferred← citeshttps://doi.org/10.1371/journal.pntd.0004497openalex-snapshot

Immune Response to Dengue Virus Infection in Pediatric Patients in New Delhi, India—Association of Viremia, Inflammatory Mediators and Monocytes with Disease Severity

inferred← citeshttps://doi.org/10.1371/journal.pntd.0005904openalex-snapshot

Human macrophages differentiated in the presence of vitamin D3 restrict dengue virus infection and innate responses by downregulating mannose receptor expression

inferred← citeshttps://doi.org/10.1371/journal.pntd.0006198openalex-snapshot

Isolation and complete genome analysis of neurotropic dengue virus serotype 3 from the cerebrospinal fluid of an encephalitis patient

inferred← citeshttps://doi.org/10.1371/journal.pntd.0013357openalex-snapshot

High seroprevalence of antibodies to Dengue, Chikungunya, and Zika viruses in Dire Dawa, Ethiopia: A cross-sectional survey in 2024

inferred← citeshttps://doi.org/10.1371/journal.pone.0007892openalex-snapshot

Gene Expression Profiling during Early Acute Febrile Stage of Dengue Infection Can Predict the Disease Outcome

inferred← citeshttps://doi.org/10.1371/journal.pone.0011671openalex-snapshot

Genome-Wide Expression Profiling Deciphers Host Responses Altered during Dengue Shock Syndrome and Reveals the Role of Innate Immunity in Severe Dengue

inferred← citeshttps://doi.org/10.1371/journal.pone.0021024openalex-snapshot

The NS1 Glycoprotein Can Generate Dramatic Antibody-Enhanced Dengue Viral Replication in Normal Out-Bred Mice Resulting in Lethal Multi-Organ Disease

inferred← citeshttps://doi.org/10.1371/journal.pone.0092056openalex-snapshot

Molecular Archaeology of Flaviviridae Untranslated Regions: Duplicated RNA Structures in the Replication Enhancer of Flaviviruses and Pestiviruses Emerged via Convergent Evolution

inferred← citeshttps://doi.org/10.1371/journal.pone.0102014openalex-snapshot

Down-Regulation of Complement Receptors on the Surface of Host Monocyte Even as In Vitro Complement Pathway Blocking Interferes in Dengue Infection

inferred← citeshttps://doi.org/10.1371/journal.pone.0136708openalex-snapshot

Source and Purity of Dengue-Viral Preparations Impact Requirement for Enhancing Antibody to Induce Elevated IL-1β Secretion: A Primary Human Monocyte Model

inferred← citeshttps://doi.org/10.1371/journal.pone.0143391openalex-snapshot

Dengue Virus Directly Stimulates Polyclonal B Cell Activation

inferred← citeshttps://doi.org/10.1371/journal.pone.0168973openalex-snapshot

Peripheral Organs of Dengue Fatal Cases Present Strong Pro-Inflammatory Response with Participation of IFN-Gamma-, TNF-Alpha- and RANTES-Producing Cells

inferred← citeshttps://doi.org/10.1371/journal.pone.0199205openalex-snapshot

Potential effects of climate change on dengue transmission dynamics in Korea

inferred← citeshttps://doi.org/10.1371/journal.pone.0210869openalex-snapshot

Thioguanine-based DENV-2 NS2B/NS3 protease inhibitors: Virtual screening, synthesis, biological evaluation and molecular modelling

inferred← citeshttps://doi.org/10.1371/journal.pone.0288392openalex-snapshot

Mathematical modeling of Dengue virus serotypes propagation in Mexico

inferred← citeshttps://doi.org/10.1371/journal.ppat.0040017openalex-snapshot

The Mannose Receptor Mediates Dengue Virus Infection of Macrophages

inferred← citeshttps://doi.org/10.1371/journal.ppat.1005345openalex-snapshot

Live Cell Analysis and Mathematical Modeling Identify Determinants of Attenuation of Dengue Virus 2’-O-Methylation Mutant

inferred← citeshttps://doi.org/10.1371/journal.ppat.1006385openalex-snapshot

Platelet proteome reveals novel pathways of platelet activation and platelet-mediated immunoregulation in dengue

inferred← citeshttps://doi.org/10.1371/journal.ppat.1007766openalex-snapshot

Primary infection with dengue or Zika virus does not affect the severity of heterologous secondary infection in macaques

inferred← citeshttps://doi.org/10.1371/journal.ppat.1008603openalex-snapshot

DENV NS1 and MMP-9 cooperate to induce vascular leakage by altering endothelial cell adhesion and tight junction

inferred← citeshttps://doi.org/10.14202/ijoh.2019.86-91openalex-snapshot

Potential of medicinal plants to treat dengue

inferred← citeshttps://doi.org/10.1515/hsz-2017-0236openalex-snapshot

Host target-based approaches against arboviral diseases

inferred← citeshttps://doi.org/10.1517/13543771003767476openalex-snapshot

Dengue vaccines: state of the art

inferred← citeshttps://doi.org/10.1517/17530050802708999openalex-snapshot

Cytokines: monitors of disease severity for the clinic

inferred← citeshttps://doi.org/10.15252/embr.202153600openalex-snapshot

Dengue virus NS1 protein conveys pro‐inflammatory signals by docking onto high‐density lipoproteins

inferred← citeshttps://doi.org/10.15625/1811-4989/19173openalex-snapshot

Expression of global consensus non-structural protein 1 (NS1) of dengue virus serotypes 1 and 2 in Nicotiana benthamiana

inferred← citeshttps://doi.org/10.1586/14760584.2013.815412openalex-snapshot

Dengue vaccines: recent developments, ongoing challenges and current candidates

inferred← citeshttps://doi.org/10.1586/14760584.7.5.569openalex-snapshot

Dengue vaccines for travelers

inferred← citeshttps://doi.org/10.1586/14787210.2015.982094openalex-snapshot

Dengue fever in Europe: could there be an epidemic in the future?

inferred← citeshttps://doi.org/10.1586/erv.09.139openalex-snapshot

Domain III of the envelope protein as a dengue vaccine target

inferred← citeshttps://doi.org/10.1590/s0036-36342009000900006openalex-snapshot

Genética de las poblaciones virales y transmisión del dengue

inferred← citeshttps://doi.org/10.17615/ajjc-6r57openalex-snapshot

Characterization of Human Antibody Responses to Dengue Virus Infections in a Sri Lankan Pediatric Cohort

inferred← citeshttps://doi.org/10.17615/r69y-vt74openalex-snapshot

Characterization of Dengue Virus Interactions with Host Cells

inferred← citeshttps://doi.org/10.17615/w97g-h526openalex-snapshot

Interfering With Inflammatory Cytokine Production During Antibody-Enhanced Dengue Virus Infection

inferred← citeshttps://doi.org/10.20546/ijcmas.2019.803.061openalex-snapshot

Analysis of Dengue Fever among Patients Attending Dutse General Hospital in Jigawa State

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