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α-5/α-3 nicotinic receptor subunit alleles increase risk for heavy smoking
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1007/s11920-006-0016-0openalex-snapshot
The genetics of nicotine dependence
inferredcites →https://doi.org/10.1016/j.bcp.2007.05.023openalex-snapshot
Heterogeneity and complexity of native brain nicotinic receptors
inferredcites →https://doi.org/10.1016/j.gene.2004.12.005openalex-snapshot
In vivo RNA–RNA duplexes from human α3 and α5 nicotinic receptor subunit mRNAs
inferredcites →https://doi.org/10.1016/s0022-3565(24)37589-5openalex-snapshot
α5 Subunit Alters Desensitization, Pharmacology, Ca++ Permeability and Ca++ Modulation of Human Neuronal α3 Nicotinic Receptors
inferredcites →https://doi.org/10.1016/s0084-3873(08)70176-7openalex-snapshot
Annual Smoking-Attributable Mortality, Years of Potential Life Lost, and Productivity Losses—United States, 1997–2001
inferredcites →https://doi.org/10.1016/s1359-6446(04)03321-5openalex-snapshot
Keynote review: Disease-specific target selection: a critical first step down the right road
inferredcites →https://doi.org/10.1017/s0033291703001582openalex-snapshot
Defining nicotine dependence for genetic research: evidence from Australian twins
inferredcites →https://doi.org/10.1017/s0033291704002405openalex-snapshot
A twin study of genetic and environmental influences on tobacco initiation, regular tobacco use and nicotine dependence
inferredcites →https://doi.org/10.1038/ng2088openalex-snapshot
A new multipoint method for genome-wide association studies by imputation of genotypes
inferredcites →https://doi.org/10.1080/14622299050011811openalex-snapshot
The genetic epidemiology of smoking
inferredcites →https://doi.org/10.1086/429839openalex-snapshot
Single- and Multilocus Allelic Variants within the GABAB Receptor Subunit 2 (GABAB2) Gene Are Significantly Associated with Nicotine Dependence
inferredcites →https://doi.org/10.1086/519795openalex-snapshot
PLINK: A Tool Set for Whole-Genome Association and Population-Based Linkage Analyses
inferredcites →https://doi.org/10.1093/hmg/ddl438openalex-snapshot
Cholinergic nicotinic receptor genes implicated in a nicotine dependence association study targeting 348 candidate genes with 3713 SNPs
inferredcites →https://doi.org/10.1093/hmg/ddl441openalex-snapshot
Novel genes identified in a high-density genome wide association study for nicotine dependence
inferredcites →https://doi.org/10.1093/ije/dyl148openalex-snapshot
Heritability of cigarette smoking and alcohol use in Chinese male twins: the Qingdao twin registry
inferredcites →https://doi.org/10.1111/j.1360-0443.1991.tb01879.xopenalex-snapshot
The Fagerström Test for Nicotine Dependence: a revision of the Fagerstrom Tolerance Questionnaire
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
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Multiple distinct risk loci for nicotine dependence identified by dense coverage of the complete family of nicotinic receptor subunit (CHRN) genes
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Variants in nicotinic acetylcholine receptors α5 and α3 increase risks to nicotine dependence
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Pharmacogenetics of Lung Cancer
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Nicotinic Acetylcholine Receptors, Cannabinoid Receptors, and Their Interplay in Drug Addiction
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The Genetics of Alcoholism and Other Addictive Disorders
inferred← citeshttps://doi.org/10.1007/978-3-540-85383-1_6openalex-snapshot
Molecular Biology of Addiction and Substance Dependence
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Biochemical Diagnosis in Substance and Non-substance Addiction
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Converging Findings from Linkage and Association Analyses on Susceptibility Genes for Smoking Addiction
inferred← citeshttps://doi.org/10.1007/978-981-10-7530-8_11openalex-snapshot
Contribution of Gene–Gene and Gene–Environment Interactions to Tobacco Smoking
inferred← citeshttps://doi.org/10.1007/978-981-95-2411-2_8openalex-snapshot
Biochemical Diagnosis in Substance and Non-substance Addiction
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inferred← citeshttps://doi.org/10.1007/s00213-013-3235-1openalex-snapshot
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inferred← citeshttps://doi.org/10.1007/s00439-010-0876-6openalex-snapshot
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inferred← citeshttps://doi.org/10.1007/s00439-010-0911-7openalex-snapshot
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inferred← citeshttps://doi.org/10.1007/s00439-011-1102-xopenalex-snapshot
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MR and GR functional SNPs may modulate tobacco smoking susceptibility
inferred← citeshttps://doi.org/10.1007/s00726-011-1149-yopenalex-snapshot
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A Twin Association Study of Nicotine Dependence with Markers in the CHRNA3 and CHRNA5 Genes
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Externalizing Behaviors are Associated with SNPs in the CHRNA5/CHRNA3/CHRNB4 Gene Cluster
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Personalized Treatment of Alcohol Dependence
inferred← citeshttps://doi.org/10.1007/s12041-016-0701-7openalex-snapshot
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inferred← citeshttps://doi.org/10.1007/s12640-011-9275-6openalex-snapshot
Positive and Negative Effects of Alcohol and Nicotine and Their Interactions: A Mechanistic Review
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Carcinogenic Effects of Cigarette Smoke on the Respiratory Tract*
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Cognitive Effects of Nicotine
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Carcinogenic Effects of Cigarette Smoke on the Respiratory Tract
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The Habenulo-Interpeduncular Pathway and Nicotine Withdrawal
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inferred← citeshttps://doi.org/10.1016/b978-0-12-813035-3.00040-xopenalex-snapshot
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Genetic imaging consortium for addiction medicine
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Association of genes coding for the α-4, α-5, β-2 and β-3 subunits of nicotinic receptors with cigarette smoking and nicotine dependence
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The intergenerational transmission of smoking in adulthood: A 25-year study of maternal and offspring maladaptive attributes
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The association between CHRN genetic variants and dizziness at first inhalation of cigarette smoke
inferred← citeshttps://doi.org/10.1016/j.addbeh.2024.108192openalex-snapshot
A novel smoking cessation behavior based on quit attempts may identify new genes associated with long-term abstinence
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New medications development for smoking cessation
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Genome-wide Association Study of Smoking Initiation and Current Smoking
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Transgenic over expression of nicotinic receptor alpha 5, alpha 3, and beta 4 subunit genes reduces ethanol intake in mice
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Radiosynthesis of ( S )-[ 18 F] T1 : The first PET radioligand for molecular imaging of α3β4 nicotinic acetylcholine receptors
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“Weeding out” violence? Translational perspectives on the neuropsychobiological links between cannabis and aggression
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Genetic variability in nicotinic acetylcholine receptors and nicotine addiction: Converging evidence from human and animal research
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The α3β4 nAChR partial agonist AT-1001 attenuates stress-induced reinstatement of nicotine seeking in a rat model of relapse and induces minimal withdrawal in dependent rats
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Nicotinic acetylcholine receptor-mediated mechanisms in lung cancer
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Recent advances in understanding nicotinic receptor signaling mechanisms that regulate drug self-administration behavior
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Methadone’s effect on nAChRs—a link between methadone use and smoking?
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High affinity α3β4 nicotinic acetylcholine receptor ligands AT-1001 and AT-1012 attenuate cocaine-induced conditioned place preference and behavioral sensitization in mice
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Stoichiometry dependent inhibition of rat α3β4 nicotinic acetylcholine receptor by the ribbon isomer of α-conotoxin AuIB
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A Risk Allele for Nicotine Dependence in CHRNA5 Is a Protective Allele for Cocaine Dependence
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Smoking Cessation and Variations in Nicotinic Acetylcholine Receptor Subunits α-5, α-3, and β-4 Genes
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Meta-Analysis of 15 Genome-Wide Linkage Scans of Smoking Behavior
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TTC12-ANKK1-DRD2 and CHRNA5-CHRNA3-CHRNB4 Influence Different Pathways Leading to Smoking Behavior from Adolescence to Mid-Adulthood
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Synthesis and activity of substituted heteroaromatics as positive allosteric modulators for α4β2α5 nicotinic acetylcholine receptors
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Functional characterization of SNPs in CHRNA3/B4 intergenic region associated with drug behaviors
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The risk of cancer in the offspring and parental length of life
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Drug Addiction: Mechanisms of Nicotine Dependence Unmasked by Gene Editing
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Scientific overview: 2013 BBC plenary symposium on tobacco addiction
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Identification of susceptibility variants to benign childhood epilepsy with centro-temporal spikes (BECTS) in Chinese Han population
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Smoking and body weight: Evidence using genetic instruments
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Research on Integrative Healthcare: Context and Priorities
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Evidence for the association of the nicotinic acetylcholine receptor CHRNA5/A3/B4 gene cluster and nicotine dependence in a young population of students
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Genetic variants as risk factors for cigarette smoking at an early age and relapse to smoking cessation treatment: A pilot study
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CHRNA5 rs16969968 and CHRNA3 rs578776 polymorphisms are associated with multiple nicotine dependence phenotypes in Bangladeshi smokers
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Time from waking to first cigarette, genetic susceptibility, and the risk of COPD: A Prospective cohort study from UK Biobank
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Meta-analysis reveals significant association between polymorphisms of CHRNA5-A3-B4 gene cluster with nicotine dependence
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Single nucleotide polymorphisms rs148582811 regulates its host gene ARVCF expression to affect nicotine-associated hippocampus-dependent memory
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Capacity building and collaborative research on cross-national studies in the Asian region
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Corticosteroid receptor genes and childhood neglect influence susceptibility to crack/cocaine addiction and response to detoxification treatment
inferred← citeshttps://doi.org/10.1016/j.lfs.2023.122100openalex-snapshot
Omega-3 fatty acids prevent nicotine withdrawal-induced impairment of learning and memory via affecting oxidative status, inflammatory response, cholinergic activity, BDNF and amyloid-B in rat hippocampal tissues
inferred← citeshttps://doi.org/10.1016/j.lungcan.2009.08.004openalex-snapshot
Blood-based CHRNA3 single nucleotide polymorphism and outcome in advanced non-small-cell lung cancer patients
inferred← citeshttps://doi.org/10.1016/j.lungcan.2016.05.008openalex-snapshot
Genome-wide association study confirms lung cancer susceptibility loci on chromosomes 5p15 and 15q25 in an African-American population
inferred← citeshttps://doi.org/10.1016/j.medcli.2011.01.008openalex-snapshot
No al “hábito”, sí a la “adicción”. Análisis crítico de un eufemismo asociado al tabaco
inferred← citeshttps://doi.org/10.1016/j.molmed.2017.12.001openalex-snapshot
Preparing the Way: Exploiting Genomic Medicine to Stop Smoking
inferred← citeshttps://doi.org/10.1016/j.neubiorev.2010.02.006openalex-snapshot
Neurobiological mechanisms involved in nicotine dependence and reward: Participation of the endogenous opioid system
inferred← citeshttps://doi.org/10.1016/j.neubiorev.2017.03.019openalex-snapshot
The role of the habenula in the transition from reward to misery in substance use and mood disorders
inferred← citeshttps://doi.org/10.1016/j.neubiorev.2023.105499openalex-snapshot
Early developmental risks for tobacco addiction: A probabilistic epigenesis framework
inferred← citeshttps://doi.org/10.1016/j.neulet.2013.02.018openalex-snapshot
Low frequency genetic variants in the μ-opioid receptor (OPRM1) affect risk for addiction to heroin and cocaine
inferred← citeshttps://doi.org/10.1016/j.neuropharm.2013.01.017openalex-snapshot
The α3β4* nicotinic acetylcholine receptor subtype mediates nicotine reward and physical nicotine withdrawal signs independently of the α5 subunit in the mouse
inferred← citeshttps://doi.org/10.1016/j.neuropharm.2013.09.008openalex-snapshot
Nicotine aversion: Neurobiological mechanisms and relevance to tobacco dependence vulnerability
inferred← citeshttps://doi.org/10.1016/j.neuropharm.2013.09.009openalex-snapshot
A glimpse into the future – Personalized medicine for smoking cessation
inferred← citeshttps://doi.org/10.1016/j.neuropharm.2013.09.023openalex-snapshot
[125I]AT-1012, a new high affinity radioligand for the α3β4 nicotinic acetylcholine receptors
inferred← citeshttps://doi.org/10.1016/j.neuropharm.2014.11.019openalex-snapshot
The habenulo-interpeduncular pathway in nicotine aversion and withdrawal
inferred← citeshttps://doi.org/10.1016/j.neuropharm.2015.02.005openalex-snapshot
Pharmacological stress is required for the anti-alcohol effect of the α3β4* nAChR partial agonist AT-1001
inferred← citeshttps://doi.org/10.1016/j.neuropharm.2015.08.015openalex-snapshot
Regulation of α4β2α5 nicotinic acetylcholinergic receptors in rat cerebral cortex in early and late adolescence: Sex differences in response to chronic nicotine
inferred← citeshttps://doi.org/10.1016/j.neuropharm.2019.107714openalex-snapshot
Sex differences in cholinergic systems in the interpeduncular nucleus following nicotine exposure and withdrawal
inferred← citeshttps://doi.org/10.1016/j.neuropharm.2020.108086openalex-snapshot
Progress in nicotinic receptor structural biology
inferred← citeshttps://doi.org/10.1016/j.neuropharm.2020.108234openalex-snapshot
Genetic susceptibility to nicotine addiction: Advances and shortcomings in our understanding of the CHRNA5/A3/B4 gene cluster contribution
inferred← citeshttps://doi.org/10.1016/j.neuropharm.2020.108256openalex-snapshot
Nicotinic acetylcholine receptors and nicotine addiction: A brief introduction
inferred← citeshttps://doi.org/10.1016/j.neuropharm.2021.108480openalex-snapshot
Linking the CHRNA5 SNP to drug abuse liability: From circuitry to cellular mechanisms
inferred← citeshttps://doi.org/10.1016/j.neuropharm.2022.109218openalex-snapshot
A common SNP in Chrna5 enhances morphine reward in female mice
inferred← citeshttps://doi.org/10.1016/j.pbb.2014.01.009openalex-snapshot
Finding genomic function for genetic associations in nicotine addiction research: The ENCODE project's role in future pharmacogenomic analysis
inferred← citeshttps://doi.org/10.1016/j.pharmthera.2009.02.003openalex-snapshot
The dynamic effects of nicotine on the developing brain
inferred← citeshttps://doi.org/10.1016/j.pharmthera.2012.08.012openalex-snapshot
Nicotinic acetylcholine receptors: From basic science to therapeutics
inferred← citeshttps://doi.org/10.1016/j.pneurobio.2010.05.003openalex-snapshot
The nicotinic acetylcholine receptor CHRNA5/A3/B4 gene cluster: Dual role in nicotine addiction and lung cancer
inferred← citeshttps://doi.org/10.1016/j.psc.2012.03.010openalex-snapshot
The Genetic Basis of Addictive Disorders
inferred← citeshttps://doi.org/10.1016/j.psychres.2015.07.002openalex-snapshot
Effect of genetic variation in the nicotinic receptor genes on risk for posttraumatic stress disorder
inferred← citeshttps://doi.org/10.1016/j.psyneuen.2021.105321openalex-snapshot
Smoking status links habenular volume to glycated hemoglobin: Findings from the Human Connectome Project-Young Adult
inferred← citeshttps://doi.org/10.1016/j.schres.2016.01.020openalex-snapshot
nAChR dysfunction as a common substrate for schizophrenia and comorbid nicotine addiction: Current trends and perspectives
inferred← citeshttps://doi.org/10.1016/j.semcdb.2009.01.001openalex-snapshot
Cellular events in nicotine addiction
inferred← citeshttps://doi.org/10.1016/j.semcdb.2017.09.030openalex-snapshot
A little rein on addiction
inferred← citeshttps://doi.org/10.1016/j.taap.2009.10.020openalex-snapshot
Nicotine-mediated signals modulate cell death and survival of T lymphocytes
inferred← citeshttps://doi.org/10.1016/j.taap.2014.04.023openalex-snapshot
Alpha5 nicotinic acetylcholine receptor mediates nicotine-induced HIF-1α and VEGF expression in non-small cell lung cancer
inferred← citeshttps://doi.org/10.1016/j.tins.2011.05.001openalex-snapshot
Historical and current perspective on tobacco use and nicotine addiction
inferred← citeshttps://doi.org/10.1016/j.tins.2016.10.005openalex-snapshot
The CHRNA5–A3–B4 Gene Cluster and Smoking: From Discovery to Therapeutics
inferred← citeshttps://doi.org/10.1016/j.tips.2009.10.004openalex-snapshot
Convergence of genetic findings for nicotine dependence and smoking related diseases with chromosome 15q24-25
inferred← citeshttps://doi.org/10.1016/j.tips.2016.11.001openalex-snapshot
Anxiety and Nicotine Dependence: Emerging Role of the Habenulo-Interpeduncular Axis
inferred← citeshttps://doi.org/10.1016/j.yrtph.2014.09.008openalex-snapshot
Smoking behaviour and compensation: A review of the literature with meta-analysis
inferred← citeshttps://doi.org/10.1016/s0034-8376(25)00256-6openalex-snapshot
Nicotine Addiction Development: From Epidemiology to Genetic Factors
inferred← citeshttps://doi.org/10.1017/cbo9781107360556.024openalex-snapshot
Substance dependence and abuse
inferred← citeshttps://doi.org/10.1017/s0033291712001274openalex-snapshot
The causal role of smoking in anxiety and depression: a Mendelian randomization analysis of the HUNT study
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.8b01372openalex-snapshot
New Rigid Nicotine Analogues, Carrying a Norbornane Moiety, Are Potent Agonists of α7 and α3* Nicotinic Receptors
inferred← citeshttps://doi.org/10.1021/acschemneuro.6b00252openalex-snapshot
Synthesis, Nicotinic Acetylcholine Receptor Binding, and in Vitro and in Vivo Pharmacological Properties of 2′-Fluoro-(substituted thiophenyl)deschloroepibatidine Analogues
inferred← citeshttps://doi.org/10.1021/jm401543hopenalex-snapshot
Scaffold Ranking and Positional Scanning Utilized in the Discovery of nAChR-Selective Compounds Suitable for Optimization Studies
inferred← citeshttps://doi.org/10.1021/jm500183ropenalex-snapshot
Discovery of a Potent and Selective α3β4 Nicotinic Acetylcholine Receptor Antagonist from an α-Conotoxin Synthetic Combinatorial Library
inferred← citeshttps://doi.org/10.1038/ejhg.2010.120openalex-snapshot
Nicotinic α5 receptor subunit mRNA expression is associated with distant 5′ upstream polymorphisms
inferred← citeshttps://doi.org/10.1038/ejhg.2010.240openalex-snapshot
Association of a variant in the CHRNA5-A3-B4 gene cluster region to heavy smoking in the Italian population
inferred← citeshttps://doi.org/10.1038/ejhg.2013.26openalex-snapshot
Association between a 15q25 gene variant, nicotine-related habits, lung cancer and COPD among 56 307 individuals from the HUNT study in Norway
inferred← citeshttps://doi.org/10.1038/jhg.2012.104openalex-snapshot
Association of IREB2 and CHRNA3/5 polymorphisms with COPD and COPD-related phenotypes in a Chinese Han population
inferred← citeshttps://doi.org/10.1038/mp.2008.71openalex-snapshot
One SNP linked to two diseases—addiction and cancer: A Double Whammy?: Nicotine addiction and lung cancer susceptibility
inferred← citeshttps://doi.org/10.1038/mp.2009.25openalex-snapshot
Role of genetic variants in the CHRNA5–CHRNA3–CHRNB4 cluster in nicotine dependence risk: importance of gene–environment interplay
inferred← citeshttps://doi.org/10.1038/mp.2009.59openalex-snapshot
Differential contribution of genetic variation in multiple brain nicotinic cholinergic receptors to nicotine dependence: recent progress and emerging open questions
inferred← citeshttps://doi.org/10.1038/mp.2011.122openalex-snapshot
The CHRNA5–A3–B4 gene cluster in nicotine addiction
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