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Effect of Agomelatine in the Chronic Mild Stress Model of Depression in the Rat

https://doi.org/10.1038/sj.npp.1300091

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Mianserin

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Zimelidine

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Melatonin in Depression

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inferred← citeshttps://doi.org/10.1016/j.physbeh.2021.113525openalex-snapshot

Chronic agomelatine treatment alleviates icvAβ-induced anxiety and depressive-like behavior through affecting Aβ metabolism in the hippocampus in a rat model of Alzheimer's disease

inferred← citeshttps://doi.org/10.1016/j.physbeh.2022.113835openalex-snapshot

Night shift hormone: How does melatonin affect depression?

inferred← citeshttps://doi.org/10.1016/j.pneurobio.2009.10.019openalex-snapshot

Melatonin maintains adult hippocampal neurogenesis and cognitive functions after irradiation

inferred← citeshttps://doi.org/10.1016/j.pneurobio.2015.12.001openalex-snapshot

New targets for rapid antidepressant action

inferred← citeshttps://doi.org/10.1016/j.pnpbp.2005.03.009openalex-snapshot

Cytokines, stressors, and clinical depression: Augmented adaptation responses underlie depression pathogenesis

inferred← citeshttps://doi.org/10.1016/j.pnpbp.2005.04.032openalex-snapshot

Antidepressant action of agomelatine (S 20098) in a transgenic mouse model

inferred← citeshttps://doi.org/10.1016/j.pnpbp.2025.111572openalex-snapshot

Agomelatine normalizes region-specific, diurnal mGluR5 dysregulation in a chronic mild stress rat model of depression

inferred← citeshttps://doi.org/10.1016/j.psychres.2007.11.020openalex-snapshot

Pathophysiology of depression: Role of sleep and the melatonergic system

inferred← citeshttps://doi.org/10.1016/j.psychres.2016.07.020openalex-snapshot

Dexmedetomidine protects against learning and memory impairments caused by electroconvulsive shock in depressed rats: Involvement of the NMDA receptor subunit 2B (NR2B)-ERK signaling pathway

inferred← citeshttps://doi.org/10.1016/j.psyneuen.2017.04.019openalex-snapshot

Systemic N-terminal fragments of adrenocorticotropin reduce inflammation- and stress-induced anhedonia in rats

inferred← citeshttps://doi.org/10.1016/j.sleep.2004.07.009openalex-snapshot

Melatonin, sleep, and circadian rhythms: rationale for development of specific melatonin agonists

inferred← citeshttps://doi.org/10.1016/j.yfrne.2019.04.003openalex-snapshot

Circadian regulation of depression: A role for serotonin

inferred← citeshttps://doi.org/10.1016/j.ynstr.2016.08.002openalex-snapshot

The chronic mild stress (CMS) model of depression: History, evaluation and usage

inferred← citeshttps://doi.org/10.1016/s0001-4079(19)32409-4openalex-snapshot

Apport de l’animal à la recherche pharmacologique

inferred← citeshttps://doi.org/10.1016/s0065-7743(04)39003-2openalex-snapshot

Melatonin Agonists for the Treatment of Sleep Disorders and Major Depression

inferred← citeshttps://doi.org/10.1016/s0924-977x(06)70008-6openalex-snapshot

Pharmacological profile of antidepressants: a likely basis for their efficacy and side effects?

inferred← citeshttps://doi.org/10.1016/s0924-977x(06)70009-8openalex-snapshot

Major depressive disorders: clinical efficacy and tolerability of agomelatine, a new melatonergic agonist

inferred← citeshttps://doi.org/10.1016/s0924-977x(11)70669-1openalex-snapshot

P.2.d.023 Agomelatine reverses the decrease in hippocampal cell survival induced by chronic mild stress

inferred← citeshttps://doi.org/10.1016/s1134-5934(08)76482-0openalex-snapshot

Agomelatina: un nuevo enfoque farmacológico en el tratamiento de la depresión con traducción clínica

inferred← citeshttps://doi.org/10.1016/s1734-1140(09)70081-7openalex-snapshot

Physiology and pharmacology of melatonin in relation to biological rhythms

inferred← citeshttps://doi.org/10.1016/s1734-1140(10)70364-9openalex-snapshot

Effects of melatonin in a place preference conditioning depend on the time of administration

inferred← citeshttps://doi.org/10.1016/s1888-9891(10)70008-2openalex-snapshot

Depresión y ritmos circadianos: relación farmacológica. El papel de la agomelatina

inferred← citeshttps://doi.org/10.1016/s1888-9891(10)70010-0openalex-snapshot

Agomelatina: un nuevo enfoque antidepresivo para una remisión de calidad

inferred← citeshttps://doi.org/10.1017/s1134066500008869openalex-snapshot

Agomelatina: un fármaco nuevo con acción antidepresiva que afecta a los sistemas melatonérgico y serotonérgico

inferred← citeshttps://doi.org/10.1017/s1461145707007766openalex-snapshot

Efficacy of agomelatine, a MT1/MT2 receptor agonist with 5-HT2C antagonistic properties, in major depressive disorder

inferred← citeshttps://doi.org/10.1017/s1461145708009115openalex-snapshot

We are in the dark here: induction of depression- and anxiety-like behaviours in the diurnal fat sand rat, by short daylight or melatonin injections

inferred← citeshttps://doi.org/10.1017/s1461145708009255openalex-snapshot

The antidepressant agomelatine blocks the adverse effects of stress on memory and enables spatial learning to rapidly increase neural cell adhesion molecule (NCAM) expression in the hippocampus of rats

inferred← citeshttps://doi.org/10.1017/s1461145709990514openalex-snapshot

Behavioural and neuroplastic effects of the new-generation antidepressant agomelatine compared to fluoxetine in glucocorticoid receptor-impaired mice

inferred← citeshttps://doi.org/10.1017/s1461145710001045openalex-snapshot

The melatonergic agonist and clinically active antidepressant, agomelatine, is a neutral antagonist at 5-HT2C receptors

inferred← citeshttps://doi.org/10.1017/s1461145711000356openalex-snapshot

Beneficial behavioural and neurogenic effects of agomelatine in a model of depression/anxiety

inferred← citeshttps://doi.org/10.1017/s1461145711001301openalex-snapshot

Efficacy of agomelatine in major depressive disorder: meta-analysis and appraisal

inferred← citeshttps://doi.org/10.1017/s1461145711001970openalex-snapshot

Chronic agomelatine treatment corrects the abnormalities in the circadian rhythm of motor activity and sleep/wake cycle induced by prenatal restraint stress in adult rats

inferred← citeshttps://doi.org/10.1037/a0035883openalex-snapshot

Rhythm and mood: Relationships between the circadian clock and mood-related behavior.

inferred← citeshttps://doi.org/10.1038/aps.2010.80openalex-snapshot

Antidepressant- and anxiolytic effects of the novel melatonin agonist Neu-P11 in rodent models

inferred← citeshttps://doi.org/10.1038/npp.2009.46openalex-snapshot

Melatonin Modulates Cell Survival of New Neurons in the Hippocampus of Adult Mice

inferred← citeshttps://doi.org/10.1038/npp.2009.72openalex-snapshot

Mechanisms Contributing to the Phase-Dependent Regulation of Neurogenesis by the Novel Antidepressant, Agomelatine, in the Adult Rat Hippocampus

inferred← citeshttps://doi.org/10.1038/npp.2012.140openalex-snapshot

Electrophysiological Effects of Repeated Administration of Agomelatine on the Dopamine, Norepinephrine, and Serotonin Systems in the Rat Brain

inferred← citeshttps://doi.org/10.1038/nrd3140openalex-snapshot

Agomelatine, the first melatonergic antidepressant: discovery, characterization and development

inferred← citeshttps://doi.org/10.1038/s41380-021-01122-0openalex-snapshot

Role of adult hippocampal neurogenesis in the antidepressant actions of lactate

inferred← citeshttps://doi.org/10.1038/s41598-025-06339-5openalex-snapshot

Fluoxetine and agomelatine mitigate anhedonic and hepatic changes in chronic restraint stress rat model

inferred← citeshttps://doi.org/10.1038/srep05632openalex-snapshot

Antidepressant-like activity of adhyperforin, a novel constituent of Hypericum perforatum L.

inferred← citeshttps://doi.org/10.1038/srep45907openalex-snapshot

Effect of agomelatine on memory deficits and hippocampal gene expression induced by chronic social defeat stress in mice

inferred← citeshttps://doi.org/10.1051/jbio:2007012openalex-snapshot

Agonistes et antagonistes des récepteurs mélatoninergiques : perspectives thérapeutiques

inferred← citeshttps://doi.org/10.1051/medsci/20052110888openalex-snapshot

Comment déveloper un antidépresseur au mécanisme d’action innovant : l’exemple de l’agomélatine

inferred← citeshttps://doi.org/10.1080/07420520500464387openalex-snapshot

Therapeutic Potential of Melatonin Ligands

inferred← citeshttps://doi.org/10.1080/07420528.2025.2478127openalex-snapshot

Circadian antidepressant treatments in depression: A systematic review and meta-analysis

inferred← citeshttps://doi.org/10.1080/09291016.2025.2584071openalex-snapshot

Agomelatine confers protection against artificial light-induced oxidative stress in chronodisrupted model of rat

inferred← citeshttps://doi.org/10.1080/10837450.2021.1888980openalex-snapshot

Brain targeting of agomelatine egg lecithin based chitosan coated nanoemulsion

inferred← citeshttps://doi.org/10.1080/15379418.2019.1703621openalex-snapshot

Acknowledgement of Reviewers for Volume 16

inferred← citeshttps://doi.org/10.1080/15622970902717024openalex-snapshot

Beyond the monoaminergic hypothesis: Agomelatine, a new antidepressant with an innovative mechanism of action

inferred← citeshttps://doi.org/10.1080/15622975.2017.1298839openalex-snapshot

Genome-wide analysis of LPS-induced inflammatory response in the rat ventral hippocampus: Modulatory activity of the antidepressant agomelatine

inferred← citeshttps://doi.org/10.1080/15622975.2018.1523560openalex-snapshot

Effects of agomelatine on behaviour, circadian expression of period 1 and period 2 clock genes and neuroplastic markers in the predator scent stress rat model of PTSD

inferred← citeshttps://doi.org/10.1080/15622975.2022.2123954openalex-snapshot

Agomelatine decreases cocaine-induced locomotor sensitisation and dopamine release in rats

inferred← citeshttps://doi.org/10.1080/17460441.2020.1781087openalex-snapshot

The preclinical discovery and development of agomelatine for the treatment of depression

inferred← citeshttps://doi.org/10.1080/j.1440-1614.2006.01814.xopenalex-snapshot

Prospects for the Treatment of Depression

inferred← citeshttps://doi.org/10.1093/ijnp/pyab092openalex-snapshot

Towards Modeling Anhedonia and Its Treatment in Zebrafish

inferred← citeshttps://doi.org/10.1093/ijnp/pyw003openalex-snapshot

Agomelatine Increases BDNF Serum Levels in Depressed Patients in Correlation with the Improvement of Depressive Symptoms

inferred← citeshttps://doi.org/10.1093/ijnp/pyx056openalex-snapshot

Dopamine System Dysregulation in Major Depressive Disorders

inferred← citeshttps://doi.org/10.1097/01.wnr.0000201507.68997.52openalex-snapshot

Fluoxetine reverses stress-induced fimbria–prefrontal long-term potentiation facilitation

inferred← citeshttps://doi.org/10.1097/01.yic.0000195658.91524.61openalex-snapshot

Sleep disturbances and depression: a challenge for antidepressants

inferred← citeshttps://doi.org/10.1097/01.yic.0000195661.37267.86openalex-snapshot

Clinical efficacy of agomelatine in depression: the evidence

inferred← citeshttps://doi.org/10.1097/01.yic.0000199456.39552.c7openalex-snapshot

Pharmacology of a new antidepressant: benefit of the implication of the melatonergic system

inferred← citeshttps://doi.org/10.1097/01.yic.0000277957.75852.c7openalex-snapshot

The interaction between the internal clock and antidepressant efficacy

inferred← citeshttps://doi.org/10.1097/01.yic.0000277958.83475.d5openalex-snapshot

Evidence of agomelatine's antidepressant efficacy: the key points

inferred← citeshttps://doi.org/10.1097/fbp.0000000000000153openalex-snapshot

Effects of long-term agomelatine treatment on the cognitive performance and hippocampal plasticity of adult rats

inferred← citeshttps://doi.org/10.1097/fbp.0000000000000359openalex-snapshot

Antidepressant-like effect of fluoxetine may depend on translocator protein activity and pretest session duration in forced swimming test in mice

inferred← citeshttps://doi.org/10.1097/fbp.0b013e3280116e5copenalex-snapshot

Antidepressant-like effects of agomelatine (S 20098) in the learned helplessness model

inferred← citeshttps://doi.org/10.1097/fjc.0000000000000136openalex-snapshot

Evaluation of the Effects of Therapeutic and Supratherapeutic Doses of Agomelatine on the QT/QTc Interval

inferred← citeshttps://doi.org/10.1097/j.pain.0000000000000738openalex-snapshot

Agomelatine: a new opportunity to reduce neuropathic pain—preclinical evidence

inferred← citeshttps://doi.org/10.1097/jcp.0b013e31825d6c25openalex-snapshot

Agomelatine Versus Venlafaxine XR in the Treatment of Anhedonia in Major Depressive Disorder

inferred← citeshttps://doi.org/10.1097/yct.0b013e3181a9947aopenalex-snapshot

Effects of Electroconvulsive Therapy and Propofol on Spatial Memory and Glutamatergic System in Hippocampus of Depressed Rats

inferred← citeshttps://doi.org/10.1097/yic.0b013e3283311acdopenalex-snapshot

The pharmacological properties of antidepressants

inferred← citeshttps://doi.org/10.1097/yic.0b013e32833a86aaopenalex-snapshot

Superior antidepressant efficacy results of agomelatine versus fluoxetine in severe MDD patients: a randomized, double-blind study

inferred← citeshttps://doi.org/10.1100/tsw.2010.65openalex-snapshot

New Therapeutic Targets for Mood Disorders

inferred← citeshttps://doi.org/10.1111/bph.12720openalex-snapshot

Agomelatine: mechanism of action and pharmacological profile in relation to antidepressant properties

inferred← citeshttps://doi.org/10.1111/j.1755-5949.2009.00125.xopenalex-snapshot

The Novel Antidepressant Agomelatine Normalizes Hippocampal Neuronal Activity and Promotes Neurogenesis in Chronically Stressed Rats

inferred← citeshttps://doi.org/10.1111/j.1755-5949.2010.00174.xopenalex-snapshot

Agomelatine: Protecting the CNS from the Effects of Stress

inferred← citeshttps://doi.org/10.1111/j.1755-5949.2010.00197.xopenalex-snapshot

Melatonin Receptor Agonists: New Options for Insomnia and Depression Treatment

inferred← citeshttps://doi.org/10.1111/nyas.12335openalex-snapshot

Circadian clocks, brain function, and development

inferred← citeshttps://doi.org/10.1111/pcn.12100openalex-snapshot

Anti‐depressive effect of polyphenols and omega‐3 fatty acid from pomegranate peel and flax seed in mice exposed to chronic mild stress

inferred← citeshttps://doi.org/10.1111/pcn.12371openalex-snapshot

Effect of subchronic administration of agomelatine on brain energy metabolism and oxidative stress parameters in rats

inferred← citeshttps://doi.org/10.1124/dmd.115.067413openalex-snapshot

Melatonin Supports CYP2D-Mediated Serotonin Synthesis in the Brain

inferred← citeshttps://doi.org/10.1124/jpet.103.051797openalex-snapshot

The Novel Melatonin Agonist Agomelatine (S20098) Is an Antagonist at 5-Hydroxytryptamine2C Receptors, Blockade of Which Enhances the Activity of Frontocortical Dopaminergic and Adrenergic Pathways

inferred← citeshttps://doi.org/10.1139/jpn.0414openalex-snapshot

Antidepressant-like activity of S 20098 (agomelatine) in the forced swimming test in rodents: involvement of melatonin and serotonin receptors

inferred← citeshttps://doi.org/10.1155/2017/1504507openalex-snapshot

Circadian Rhythm Disturbances in Mood Disorders: Insights into the Role of the Suprachiasmatic Nucleus

inferred← citeshttps://doi.org/10.1176/appi.neuropsych.11090216openalex-snapshot

Agomelatine in Depressive Disorders: Its Novel Mechanisms of Action

inferred← citeshttps://doi.org/10.1177/0269881108092593openalex-snapshot

Agomelatine, an innovative pharmacological response to unmet needs

inferred← citeshttps://doi.org/10.1177/0960327114559613openalex-snapshot

The combination of agomelatine and ritanserin exerts a synergistic interaction in passive avoidance task

inferred← citeshttps://doi.org/10.1177/1359786810372981openalex-snapshot

Review: Restoring circadian rhythms: a new way to successfully manage depression

inferred← citeshttps://doi.org/10.1186/1471-2202-11-68openalex-snapshot

Blockade of stress-induced increase of glutamate release in the rat prefrontal/frontal cortex by agomelatine involves synergy between melatonergic and 5-HT2C receptor-dependent pathways

inferred← citeshttps://doi.org/10.1186/s13041-017-0306-yopenalex-snapshot

The role of 5-HT receptors in depression

inferred← citeshttps://doi.org/10.1201/b11101-2openalex-snapshot

Melatonin Time Line

inferred← citeshttps://doi.org/10.1201/b17448-28openalex-snapshot

Melatonergic Drugs as Therapeutic Agents for Insomnia and Depressive Disorders

inferred← citeshttps://doi.org/10.1208/s12248-019-0379-xopenalex-snapshot

Application of Item Response Theory to Model Disease Progression and Agomelatine Effect in Patients with Major Depressive Disorder

inferred← citeshttps://doi.org/10.13040/ijpsr.0975-8232.9(8).3210-22openalex-snapshot

inferred← citeshttps://doi.org/10.1345/aph.1l296openalex-snapshot

Agomelatine Treatment of Major Depressive Disorder

inferred← citeshttps://doi.org/10.1371/journal.pone.0004326openalex-snapshot

Chronic Mild Stress (CMS) in Mice: Of Anhedonia, ‘Anomalous Anxiolysis’ and Activity

inferred← citeshttps://doi.org/10.1371/journal.pone.0278231openalex-snapshot

Fast-onset effects of Pseudospondias microcarpa (A. Rich) Engl. (Anacardiaceae) hydroethanolic leaf extract on behavioral alterations induced by chronic mild stress in mice

inferred← citeshttps://doi.org/10.14712/fb2016062060250openalex-snapshot

Anxiety and Hyperlocomotion Induced by Chronic Unpredictable Mild Stress Can Be Moderated with Melatonin Treatment

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