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The p53 pathway: positive and negative feedback loops
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1002/j.1460-2075.1994.tb06807.xopenalex-snapshot
Cyclin G is a transcriptional target of the p53 tumor suppressor protein.
inferredcites →https://doi.org/10.1007/bf03401678openalex-snapshot
A Genetic Approach to Mapping the p53 Binding Site in the MDM2 Protein
inferredcites →https://doi.org/10.1007/bf03401903openalex-snapshot
The MDM2 Oncoprotein Binds Specifically to RNA through its RING Finger Domain
inferredcites →https://doi.org/10.1007/s00018-003-3304-4openalex-snapshot
The common and distinct target genes of the p53 family transcription factors
inferredcites →https://doi.org/10.1016/s0014-5793(98)00650-4openalex-snapshot
Individual promoter and intron p53‐binding motifs from the rat Cyclin G1 promoter region support transcriptional activation by p53 but do not show co‐operative activation
inferredcites →https://doi.org/10.1016/s0092-8674(00)80540-1openalex-snapshot
Monoallelically Expressed Gene Related to p53 at 1p36, a Region Frequently Deleted in Neuroblastoma and Other Human Cancers
inferredcites →https://doi.org/10.1016/s0092-8674(03)00193-4openalex-snapshot
Pirh2, a p53-Induced Ubiquitin-Protein Ligase, Promotes p53 Degradation
inferredcites →https://doi.org/10.1016/s0959-437x(02)00013-8openalex-snapshot
Tumor suppression by Ink4a–Arf: progress and puzzles
inferredcites →https://doi.org/10.1016/s1097-2765(00)80275-0openalex-snapshot
p63, a p53 Homolog at 3q27–29, Encodes Multiple Products with Transactivating, Death-Inducing, and Dominant-Negative Activities
inferredcites →https://doi.org/10.1016/s1097-2765(02)00504-xopenalex-snapshot
Cyclin G Recruits PP2A to Dephosphorylate Mdm2
inferredcites →https://doi.org/10.1016/s1097-2765(03)00057-1openalex-snapshot
Nucleolar Arf Tumor Suppressor Inhibits Ribosomal RNA Processing
inferredcites →https://doi.org/10.1016/s1383-5742(00)00035-1openalex-snapshot
Regulation of p53 stability and activity in response to genotoxic stress
inferredcites →https://doi.org/10.1016/s1535-6108(03)00079-5openalex-snapshot
p53 polymorphism influences response in cancer chemotherapy via modulation of p73-dependent apoptosis
inferredcites →https://doi.org/10.1016/s1535-6108(03)00134-xopenalex-snapshot
Regulation of HDM2 activity by the ribosomal protein L11
inferredcites →https://doi.org/10.1038/25867openalex-snapshot
p14ARF links the tumour suppressors RB and p53
inferredcites →https://doi.org/10.1038/25870openalex-snapshot
p19ARF links the tumour suppressor p53 to Ras
inferredcites →https://doi.org/10.1038/375694a0openalex-snapshot
Interaction between the retinoblastoma protein and the oncoprotein MDM2
inferredcites →https://doi.org/10.1038/378203a0openalex-snapshot
Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53
inferredcites →https://doi.org/10.1038/378206a0openalex-snapshot
Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53
inferredcites →https://doi.org/10.1038/38298openalex-snapshot
p73 is a human p53-related protein that can induce apoptosis
inferredcites →https://doi.org/10.1038/75586openalex-snapshot
A common polymorphism acts as an intragenic modifier of mutant p53 behaviour
inferredcites →https://doi.org/10.1038/nature02514openalex-snapshot
The ubiquitin ligase COP1 is a critical negative regulator of p53
inferredcites →https://doi.org/10.1038/ng1293openalex-snapshot
Dynamics of the p53-Mdm2 feedback loop in individual cells
inferredcites →https://doi.org/10.1038/nrc1277openalex-snapshot
Radiation-induced bystander effects — implications for cancer
inferredcites →https://doi.org/10.1038/nrc992openalex-snapshot
The role of p53 in determining sensitivity to radiotherapy
inferredcites →https://doi.org/10.1038/sj.bjc.6602164openalex-snapshot
Targeting the p53–MDM2 interaction to treat cancer
inferredcites →https://doi.org/10.1038/sj.cdd.4400962openalex-snapshot
Human ΔNp73 regulates a dominant negative feedback loop for TAp73 and p53
inferredcites →https://doi.org/10.1038/sj.cdd.4401183openalex-snapshot
Decision making by p53: life, death and cancer
inferredcites →https://doi.org/10.1038/sj.onc.1201734openalex-snapshot
p53 mutations isolated in yeast based on loss of transcription factor activity: similarities and differences from p53 mutations detected in human tumors
inferredcites →https://doi.org/10.1038/sj.onc.1202303openalex-snapshot
Stress-induced secretion of growth inhibitors: a novel tumor suppressor function of p53
inferredcites →https://doi.org/10.1038/sj.onc.1202314openalex-snapshot
Mutant p53 gain of function: differential effects of different p53 mutants on resistance of cultured cells to chemotherapy
inferredcites →https://doi.org/10.1038/sj.onc.1203434openalex-snapshot
Quantitative analysis of residual folding and DNA binding in mutant p53 core domain: definition of mutant states for rescue in cancer therapy
inferredcites →https://doi.org/10.1038/sj.onc.1204270openalex-snapshot
Cyclin G1 is involved in G2/M arrest in response to DNA damage and in growth control after damage recovery
inferredcites →https://doi.org/10.1038/sj.onc.1205181openalex-snapshot
Cross-talk between Akt, p53 and Mdm2: possible implications for the regulation of apoptosis
inferredcites →https://doi.org/10.1038/sj.onc.1205584openalex-snapshot
p53 induces the expression of its antagonist p73ΔN, establishing an autoregulatory feedback loop
inferredcites →https://doi.org/10.1038/sj.onc.1206682openalex-snapshot
DNA damage checkpoint control in cells exposed to ionizing radiation
inferredcites →https://doi.org/10.1038/sj.onc.1208016openalex-snapshot
Siah-1L, a novel transcript variant belonging to the human Siah family of proteins, regulates β-catenin activity in a p53-dependent manner
inferredcites →https://doi.org/10.1046/j.1432-1327.2001.02225.xopenalex-snapshot
Post‐translational modifications and activation of p53 by genotoxic stresses
inferredcites →https://doi.org/10.1073/pnas.0400177101openalex-snapshot
Siah-1b is a direct transcriptional target of p53: Identification of the functional p53 responsive element in the siah-1b promoter
inferredcites →https://doi.org/10.1073/pnas.052713099openalex-snapshot
Targeted point mutations of p53 lead to dominant-negative inhibition of wild-type p53 function
inferredcites →https://doi.org/10.1073/pnas.1031695100openalex-snapshot
Inhibition of p53-induced apoptosis without affecting expression of p53-regulated genes
inferredcites →https://doi.org/10.1073/pnas.132268899openalex-snapshot
The p53MH algorithm and its application in detecting p53-responsive genes
inferredcites →https://doi.org/10.1073/pnas.1934852100openalex-snapshot
The presence of p53 mutations in human osteosarcomas correlates with high levels of genomic instability
inferredcites →https://doi.org/10.1073/pnas.210171597openalex-snapshot
Generation of oscillations by the p53-Mdm2 feedback loop: A theoretical and experimental study
inferredcites →https://doi.org/10.1073/pnas.91.9.3602openalex-snapshot
p53 and E2F-1 cooperate to mediate apoptosis.
inferredcites →https://doi.org/10.1074/jbc.275.10.7337openalex-snapshot
p53 Induces Apoptosis by Caspase Activation through Mitochondrial Cytochrome c Release
inferredcites →https://doi.org/10.1074/jbc.c400300200openalex-snapshot
Topors Functions as an E3 Ubiquitin Ligase with Specific E2 Enzymes and Ubiquitinates p53
inferredcites →https://doi.org/10.1074/jbc.m011326200openalex-snapshot
Cyclin A-CDK Phosphorylation Regulates MDM2 Protein Interactions
inferredcites →https://doi.org/10.1074/jbc.m301264200openalex-snapshot
The Promyelocytic Leukemia Protein Protects p53 from Mdm2-mediated Inhibition and Degradation
inferredcites →https://doi.org/10.1074/jbc.m308302200openalex-snapshot
MDM2 and Promyelocytic Leukemia Antagonize Each Other through Their Direct Interaction with p53
inferredcites →https://doi.org/10.1074/jbc.m312305200openalex-snapshot
Myc-ARF (Alternate Reading Frame) Interaction Inhibits the Functions of Myc
inferredcites →https://doi.org/10.1074/jbc.m403722200openalex-snapshot
Inhibition of MDM2-mediated p53 Ubiquitination and Degradation by Ribosomal Protein L5
inferredcites →https://doi.org/10.1093/emboj/17.17.5001openalex-snapshot
The alternative product from the human CDKN2A locus, p14ARF, participates in a regulatory feedback loop with p53 and MDM2
inferredcites →https://doi.org/10.1093/emboj/18.1.22openalex-snapshot
Association of p19ARF with Mdm2 inhibits ubiquitin ligase activity of Mdm2 for tumor suppressor p53
inferredcites →https://doi.org/10.1093/emboj/19.23.6517openalex-snapshot
p53‐inducible Wip1 phosphatase mediates a negative feedback regulation of p38 MAPK‐p53 signaling in response to UV radiation
inferredcites →https://doi.org/10.1093/emboj/20.17.4912openalex-snapshot
Deregulated β‐catenin induces a p53‐ and ARF‐dependent growth arrest and cooperates with Ras in transformation
inferredcites →https://doi.org/10.1096/fj.00-0171fjeopenalex-snapshot
The Werner syndrome protein contributes to induction of p53 by DNA damage
inferredcites →https://doi.org/10.1101/gad.12.15.2424openalex-snapshot
Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization
inferredcites →https://doi.org/10.1101/gad.12.15.2434openalex-snapshot
E1A signaling to p53 involves the p19ARFtumor suppressor
inferredcites →https://doi.org/10.1101/gad.12.19.2973openalex-snapshot
The complexity of p53 modulation: emerging patterns from divergent signals
inferredcites →https://doi.org/10.1101/gad.7.7a.1266openalex-snapshot
The p65 subunit of NF-kappa B regulates I kappa B by two distinct mechanisms.
inferredcites →https://doi.org/10.1101/gad.8.10.1235openalex-snapshot
Several hydrophobic amino acids in the p53 amino-terminal domain are required for transcriptional activation, binding to mdm-2 and the adenovirus 5 E1B 55-kD protein.
inferredcites →https://doi.org/10.1111/j.1349-7006.2004.tb03163.xopenalex-snapshot
Isolation of p53‐target genes and their functional analysis
inferredcites →https://doi.org/10.1126/science.1978757openalex-snapshot
Germ Line p53 Mutations in a Familial Syndrome of Breast Cancer, Sarcomas, and Other Neoplasms
inferredcites →https://doi.org/10.1126/science.274.5289.948openalex-snapshot
Structure of the MDM2 Oncoprotein Bound to the p53 Tumor Suppressor Transactivation Domain
inferredcites →https://doi.org/10.1126/science.282.5387.290openalex-snapshot
Cell Surface Trafficking of Fas: A Rapid Mechanism of p53-Mediated Apoptosis
inferredcites →https://doi.org/10.1128/aem.62.4.1306-1310.1996openalex-snapshot
Characterization of a Novel Strain of Bacillus thuringiensis
inferredcites →https://doi.org/10.1128/mcb.12.12.5581openalex-snapshot
Identification of a Minimal Transforming Domain of p53: Negative Dominance through Abrogation of Sequence-Specific DNA Binding
inferredcites →https://doi.org/10.1128/mcb.14.11.7414openalex-snapshot
The Ribosomal L5 Protein Is Associated with mdm-2 and mdm-2-p53 Complexes
inferredcites →https://doi.org/10.1128/mcb.21.5.1874-1887.2001openalex-snapshot
A Subset of Tumor-Derived Mutant Forms of p53 Down-Regulate p63 and p73 through a Direct Interaction with the p53 Core Domain
inferredcites →https://doi.org/10.1128/mcb.23.23.8902-8912.2003openalex-snapshot
Ribosomal Protein L11 Negatively Regulates Oncoprotein MDM2 and Mediates a p53-Dependent Ribosomal-Stress Checkpoint Pathway
inferredcites →https://doi.org/10.1128/mcb.24.15.6728-6741.2004openalex-snapshot
In Vivo Mitochondrial p53 Translocation Triggers a Rapid First Wave of Cell Death in Response to DNA Damage That Can Precede p53 Target Gene Activation
inferredcites →https://doi.org/10.1128/mcb.24.17.7654-7668.2004openalex-snapshot
Ribosomal Protein L23 Activates p53 by Inhibiting MDM2 Function in Response to Ribosomal Perturbation but Not to Translation Inhibition
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
inferred← citeshttps://doi.org/10.1002/1878-0261.13421openalex-snapshot
LIM domain‐containing protein Ajuba inhibits chemotherapy‐induced apoptosis by negatively regulating p53 stability in colorectal cancer cells
inferred← citeshttps://doi.org/10.1002/1878-0261.13786openalex-snapshot
Tonabersat enhances temozolomide‐mediated cytotoxicity in glioblastoma by disrupting intercellular connectivity through connexin 43 inhibition
inferred← citeshttps://doi.org/10.1002/1878-0261.70275openalex-snapshot
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
inferred← citeshttps://doi.org/10.1002/9780470048672.wecb472openalex-snapshot
Programmed Cell Death as a Therapeutic Approach
inferred← citeshttps://doi.org/10.1002/9781118140574.ch13openalex-snapshot
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inferred← citeshttps://doi.org/10.1002/9781118527948.ch1openalex-snapshot
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inferred← citeshttps://doi.org/10.1002/9783527619665.ch10openalex-snapshot
The Role of the Apoptosome in Apoptosis and Cancer Therapy
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A Responsive Hydrogel Containing Bimetallic MOF Enabling Amplified Ferroptosis for Cancer Therapy via Dual Cellular Homeostasis Disruption
inferred← citeshttps://doi.org/10.1002/advs.202519669openalex-snapshot
Mr BMT Achieves Systemic Macrophage Replacement With Preservation of Tissue Homeostasis
inferred← citeshttps://doi.org/10.1002/aic.11842openalex-snapshot
Autocatalysis in biological systems
inferred← citeshttps://doi.org/10.1002/ajh.21772openalex-snapshot
Cost‐effectiveness of hydroxyurea in reducing the frequency of pain episodes and hospitalization in pediatric sickle cell disease
inferred← citeshttps://doi.org/10.1002/ajh.21834openalex-snapshot
Association with TP53 codon 72 polymorphism and the risk of non‐Hodgkin lymphoma
inferred← citeshttps://doi.org/10.1002/ange.200600611openalex-snapshot
p53 – ein natürlicher Krebskiller: Einsichten in die Struktur und Therapiekonzepte
inferred← citeshttps://doi.org/10.1002/ange.201410434openalex-snapshot
Toward the Design of a Catalytic Metallodrug: Selective Cleavage of G‐Quadruplex Telomeric DNA by an Anticancer Copper–Acridine–ATCUN Complex
inferred← citeshttps://doi.org/10.1002/anie.200600611openalex-snapshot
p53—A Natural Cancer Killer: Structural Insights and Therapeutic Concepts
inferred← citeshttps://doi.org/10.1002/anie.201410434openalex-snapshot
Toward the Design of a Catalytic Metallodrug: Selective Cleavage of G‐Quadruplex Telomeric DNA by an Anticancer Copper–Acridine–ATCUN Complex
inferred← citeshttps://doi.org/10.1002/ar.23807openalex-snapshot
Morphological and Biochemical Features of Cerebellar Cortex After Exposure to Zinc Oxide Nanoparticles: Possible Protective Role of Curcumin
inferred← citeshttps://doi.org/10.1002/bdra.20539openalex-snapshot
Understanding the causes and prevention of neural tube defects: Insights from the splotch mouse model
inferred← citeshttps://doi.org/10.1002/bdra.20565openalex-snapshot
Gene and microRNA expression in p53‐deficient day 8.5 mouse embryos
inferred← citeshttps://doi.org/10.1002/biof.1065openalex-snapshot
Molecular mechanisms of curcumin action: Signal transduction
inferred← citeshttps://doi.org/10.1002/cam4.5776openalex-snapshot
SMARCA4 and SMARCE1 in gastric cancer: Correlation with ARID1A , and microsatellite stability, and SMARCE1 / ERBB2 co‐amplification
inferred← citeshttps://doi.org/10.1002/cam4.71922openalex-snapshot
Proteomic Differentiation of Colorectal Cancer From Normal Tissue via Ex Vivo E‐Biopsy: A Novel Approach to Molecular Sampling for Diagnostic Precision
inferred← citeshttps://doi.org/10.1002/cbf.1818openalex-snapshot
Acute loss of DP1, but not DP2, induces p53 mRNA and augments p21Waf1/Cip1 and senescence
inferred← citeshttps://doi.org/10.1002/cbf.3783openalex-snapshot
MicroRNA transcriptomics in liver of the freeze‐tolerant gray tree frog (Dryophytes versicolor) indicates suppression of energy‐expensive pathways
inferred← citeshttps://doi.org/10.1002/cbf.4075openalex-snapshot
Working title: Molecular involvement of p53‐MDM2 interactome in gastrointestinal cancers
inferred← citeshttps://doi.org/10.1002/cem.2503openalex-snapshot
Compressed images for affinity prediction (CIFAP): a study on predicting binding affinities for checkpoint kinase 1 protein inhibitors
inferred← citeshttps://doi.org/10.1002/cmdc.201900201openalex-snapshot
Structural States of Hdm2 and HdmX: X‐ray Elucidation of Adaptations and Binding Interactions for Different Chemical Compound Classes
inferred← citeshttps://doi.org/10.1002/cncr.24494openalex-snapshot
p53‐induced RING‐H2 protein, a novel marker for poor survival in hepatocellular carcinoma after hepatic resection
inferred← citeshttps://doi.org/10.1002/cphy.c110046openalex-snapshot
Role of Ion Transport in Control of Apoptotic Cell Death
inferred← citeshttps://doi.org/10.1002/ddr.20151openalex-snapshot
Targeting the p53 tumor suppressor gene function in glioblastomas using small chemical molecules
inferred← citeshttps://doi.org/10.1002/elps.201000033openalex-snapshot
Proteomic profiling of human colon cancer cells treated with the histone deacetylase inhibitor belinostat
inferred← citeshttps://doi.org/10.1002/glia.70094openalex-snapshot
Chemogenetic Activation of Oligodendrocytes Delays Postnatal Myelination by Promoting Progenitor Proliferation and Inhibiting Maturation
inferred← citeshttps://doi.org/10.1002/hep.22656openalex-snapshot
Hepatic function is preserved in the absence of mature microRNAs #
inferred← citeshttps://doi.org/10.1002/humu.21214openalex-snapshot
ΔN133p53 expression levels in relation to haplotypes of the TP53 internal promoter region
inferred← citeshttps://doi.org/10.1002/iid3.375openalex-snapshot
Data mining combined with experiments to validate CEP55 as a prognostic biomarker in colorectal cancer
inferred← citeshttps://doi.org/10.1002/ijc.21794openalex-snapshot
Down regulation of 3p genes, LTF, SLC38A3 and DRR1, upon growth of human chromosome 3–mouse fibrosarcoma hybrids in severe combined immunodeficiency mice
inferred← citeshttps://doi.org/10.1002/ijc.22362openalex-snapshot
In vivo evaluation of the role of DNp73α protein in regulating the p53‐dependent apoptotic pathway after treatment with cytotoxic drugs
inferred← citeshttps://doi.org/10.1002/ijc.22725openalex-snapshot
Gene expression profiling in melanoma identifies novel downstream effectors of p14ARF
inferred← citeshttps://doi.org/10.1002/ijc.23599openalex-snapshot
Multiple B‐vitamin inadequacy amplifies alterations induced by folate depletion in p53 expression and its downstream effector MDM2
inferred← citeshttps://doi.org/10.1002/ijc.24259openalex-snapshot
Ascochlorin activates p53 in a manner distinct from DNA damaging agents
inferred← citeshttps://doi.org/10.1002/ijc.24861openalex-snapshot
Chemotherapy‐induced apoptosis in hepatocellular carcinoma involves the p53 family and is mediated via the extrinsic and the intrinsic pathway
inferred← citeshttps://doi.org/10.1002/ijc.25345openalex-snapshot
p53 transactivation is involved in the antiproliferative activity of the putative tumor suppressor RBM5
inferred← citeshttps://doi.org/10.1002/ijc.25414openalex-snapshot
Epstein‐Barr virus‐encoded EBNA‐5 forms trimolecular protein complexes with MDM2 and p53 and inhibits the transactivating function of p53
inferred← citeshttps://doi.org/10.1002/iub.2523openalex-snapshot
The mechanism research on the anti‐liver fibrosis of emodin based on network pharmacology
inferred← citeshttps://doi.org/10.1002/j.2040-4603.2012.tb00451.xopenalex-snapshot
Role of Ion Transport in Control of Apoptotic Cell Death
inferred← citeshttps://doi.org/10.1002/jbio.201500237openalex-snapshot
Systematic evaluation of the biological variance within the Raman based colorectal tissue diagnostics
inferred← citeshttps://doi.org/10.1002/jbt.22869openalex-snapshot
Polydatin gold nanoparticles potentiate antitumor effect of doxorubicin in Ehrlich ascites carcinoma‐bearing mice
inferred← citeshttps://doi.org/10.1002/jcb.20919openalex-snapshot
Inhibition of PP2A, but not PP5, mediates p53 activation by low levels of okadaic acid in rat liver epithelial cells
inferred← citeshttps://doi.org/10.1002/jcb.21122openalex-snapshot
The kinetics of p53‐binding and histone acetylation at target promoters do not strictly correlate with gene expression after UV damage
inferred← citeshttps://doi.org/10.1002/jcb.21381openalex-snapshot
P53 mediated regulation of metallothionein transcription in breast cancer cells
inferred← citeshttps://doi.org/10.1002/jcb.21937openalex-snapshot
Chromosome instability and tumor lethality suppression in carcinogenesis
inferred← citeshttps://doi.org/10.1002/jcb.24698openalex-snapshot
An Unconventional Role of BMP‐Smad1 Signaling in DNA Damage Response: A Mechanism for Tumor Suppression
inferred← citeshttps://doi.org/10.1002/jcb.25616openalex-snapshot
17β‐Estradiol Protects Skeletal Myoblasts From Apoptosis Through p53, Bcl‐2, and FoxO Families
inferred← citeshttps://doi.org/10.1002/jcb.28188openalex-snapshot
Signaling Crosstalk of FHIT, p53, and p38 in etoposide‐induced apoptosis in MCF‐7 cells
inferred← citeshttps://doi.org/10.1002/jcb.29178openalex-snapshot
MicroRNA‐488‐3p inhibits proliferation and induces apoptosis by targeting ZBTB2 in esophageal squamous cell carcinoma
inferred← citeshttps://doi.org/10.1002/jcb.29246openalex-snapshot
Considering smoking status, coexpression network analysis of non–small cell lung cancer at different cancer stages, exhibits important genes and pathways
inferred← citeshttps://doi.org/10.1002/jcp.20590openalex-snapshot
Immunohistochemical evaluation of pRb2/p130, VEGF, EZH2, p53, p16, p21waf‐1, p27, and PCNA in Barrett's esophagus
inferred← citeshttps://doi.org/10.1002/jcp.20818openalex-snapshot
Deregulation of cyclin E meets dysfunction in p53: Closing the escape hatch on breast cancer
inferred← citeshttps://doi.org/10.1002/jcp.21583openalex-snapshot
The ING gene family in the regulation of cell growth and tumorigenesis
inferred← citeshttps://doi.org/10.1002/jcp.25669openalex-snapshot
SirT3 and p53 Deacetylation in Aging and Cancer
inferred← citeshttps://doi.org/10.1002/jgm.1424openalex-snapshot
Inhibition of the p53–MDM2 interaction by adenovirus delivery of ribosomal protein L23 stabilizes p53 and induces cell cycle arrest and apoptosis in gastric cancer
inferred← citeshttps://doi.org/10.1002/jmr.999openalex-snapshot
Interaction of p53 with Mdm2 and azurin as studied by atomic force spectroscopy
inferred← citeshttps://doi.org/10.1002/jso.21920openalex-snapshot
Loss of p53 in esophageal squamous cell carcinoma and the correlation with survival: Analyses of gene mutations, protein expression, and loss of heterozygosity in Japanese patients
inferred← citeshttps://doi.org/10.1002/jso.22004openalex-snapshot
Wip1 over‐expression correlated with TP53/p14ARF pathway disruption in human astrocytomas
inferred← citeshttps://doi.org/10.1002/mc.20245openalex-snapshot
Arsenite inhibits p53 phosphorylation, DNA binding activity, and p53 target gene p21 expression in mouse epidermal JB6 cells,
inferred← citeshttps://doi.org/10.1002/mc.20338openalex-snapshot
The Rb family connects with the Tp53 family in skin carcinogenesis
inferred← citeshttps://doi.org/10.1002/mc.20477openalex-snapshot
Delphinidin, an anthocyanidin in pigmented fruits and vegetables, induces apoptosis and cell cycle arrest in human colon cancer HCT116 cells
inferred← citeshttps://doi.org/10.1002/mc.20570openalex-snapshot
Involvement of p53 in oroxylin A‐induced apoptosis in cancer cells
inferred← citeshttps://doi.org/10.1002/mc.20727openalex-snapshot
MDM2 SNP309 contributes to non‐small cell lung cancer survival in Chinese
inferred← citeshttps://doi.org/10.1002/mc.20807openalex-snapshot
XIAP‐associated factor 1 (XAF1), a novel target of p53, enhances p53‐mediated apoptosis via post‐translational modification
inferred← citeshttps://doi.org/10.1002/mc.22120openalex-snapshot
A critical role for the long non‐coding RNA GAS5 in proliferation and apoptosis in non‐small‐cell lung cancer
inferred← citeshttps://doi.org/10.1002/mc.22175openalex-snapshot
Regulation of p53‐targeting microRNAs by polycyclic aromatic hydrocarbons: Implications in the etiology of multiple myeloma
inferred← citeshttps://doi.org/10.1002/mc.23332openalex-snapshot
A rohitukine derivative IIIM‐290 induces p53 dependent mitochondrial apoptosis in acute lymphoblastic leukemia cells
inferred← citeshttps://doi.org/10.1002/med.20236openalex-snapshot
Small molecule agents targeting the p53‐MDM2 pathway for cancer therapy
inferred← citeshttps://doi.org/10.1002/path.1913openalex-snapshot
Assessing p53 in clinical contexts: unlearned lessons and new perspectives
inferred← citeshttps://doi.org/10.1002/path.2086openalex-snapshot
p53: at the crossroad between cancer and ageing
inferred← citeshttps://doi.org/10.1002/path.2238openalex-snapshot
The p53–Mdm2 network in progenitor cell expansion during mouse postnatal development
inferred← citeshttps://doi.org/10.1002/path.2612openalex-snapshot
The p53‐mediated sensitivity of cancer cells to chemotherapeutic agents is conditioned by the status of the retinoblastoma protein
inferred← citeshttps://doi.org/10.1002/path.2670openalex-snapshot
Molecular targeted therapies for diffuse large B‐cell lymphoma based on apoptosis profiles
inferred← citeshttps://doi.org/10.1002/path.4478openalex-snapshot
UBTD1 induces cellular senescence through an UBTD1 –Mdm2/p53 positive feedback loop
inferred← citeshttps://doi.org/10.1002/path.6270openalex-snapshot
Patterns of structural variants within TP53 introns and relocation of the TP53 promoter: a commentary†
inferred← citeshttps://doi.org/10.1002/ppap.201600090openalex-snapshot
Redox‐regulation of activator protein 1 family members in blood cancer cell lines exposed to cold physical plasma‐treated medium
inferred← citeshttps://doi.org/10.1002/pros.20784openalex-snapshot
Association between polymorphisms in cell cycle genes and advanced prostate carcinoma
inferred← citeshttps://doi.org/10.1002/psp4.13029openalex-snapshot
A dynamic model of the intestinal epithelium integrates multiple sources of preclinical data and enables clinical translation of drug‐induced toxicity
inferred← citeshttps://doi.org/10.1002/ptr.4841openalex-snapshot
The Novel p53‐Dependent Metastatic and Apoptotic Pathway Induced by Vitexin in Human Oral Cancer OC2 Cells
inferred← citeshttps://doi.org/10.1002/smll.202006055openalex-snapshot
In Vitro Three‐Dimensional Liver Models for Nanomaterial DNA Damage Assessment
inferred← citeshttps://doi.org/10.1002/smll.202512024openalex-snapshot
Acetylated Nanoformulation of N‐(4‐Hydroxyphenyl)‐4‐Oxoretinamide Inhibits EZH2‐Mediated Epigenetic Repression in Neuroblastoma
inferred← citeshttps://doi.org/10.1002/stem.1108openalex-snapshot
MicroRNAs Regulate p21Waf1/Cip1 Protein Expression and the DNA Damage Response in Human Embryonic Stem Cells
inferred← citeshttps://doi.org/10.1002/stem.1147openalex-snapshot
Sirt1, p53, and p38MAPKAre Crucial Regulators of Detrimental Phenotypes of Embryonic Stem Cells withMaxExpression Ablation
inferred← citeshttps://doi.org/10.1002/tox.22685openalex-snapshot
Bergapten induces G1 arrest and pro‐apoptotic cascade in colorectal cancer cells associating with p53/p21/PTEN axis
inferred← citeshttps://doi.org/10.1002/tox.23546openalex-snapshot
The effect of low molecular weight‐polycyclic aromatic hydrocarbons responsive hsa_circ_0039929/hsa‐miR‐15b‐3p_R‐1/FGF2 circuit on inflammatory response of A549 cells via the PI3K/AKT pathway and epithelial‐mesenchymal transition process
inferred← citeshttps://doi.org/10.1002/uog.20103openalex-snapshot
Premature placental aging in term small‐for‐gestational‐age and growth‐restricted fetuses
inferred← citeshttps://doi.org/10.1002/wsbm.52openalex-snapshot
Computational modeling of mammalian signaling networks
inferred← citeshttps://doi.org/10.1007/1-4020-4709-6_15openalex-snapshot
Integration of Signaling Pathways Via Smad Proteins
inferred← citeshttps://doi.org/10.1007/82_2010_110openalex-snapshot
Small-Molecule Inhibitors of the p53-MDM2 Interaction
inferred← citeshttps://doi.org/10.1007/978-0-387-09794-7_2openalex-snapshot
Oscillations by the p53-Mdm2 Feedback Loop
inferred← citeshttps://doi.org/10.1007/978-0-387-72114-9_2openalex-snapshot
Molecular Genetics of Lung and Pleural Neoplasms
inferred← citeshttps://doi.org/10.1007/978-0-387-89445-4_9openalex-snapshot
Drug Resistance and the Tumor Suppressor p53: The Paradox of Wild-Type Genotype in Chemorefractory Cancers
inferred← citeshttps://doi.org/10.1007/978-0-8176-4751-3_5openalex-snapshot
Signaling and Feedback in Biological Networks
inferred← citeshttps://doi.org/10.1007/978-1-4020-8352-5_4openalex-snapshot
Phosphorylation Dynamics in Mammalian Cells
inferred← citeshttps://doi.org/10.1007/978-1-4020-8696-0openalex-snapshot
Targeted Radionuclide Tumor Therapy
inferred← citeshttps://doi.org/10.1007/978-1-4020-8696-0_12openalex-snapshot
Radiation Induced Cell Deaths
inferred← citeshttps://doi.org/10.1007/978-1-4020-9597-9openalex-snapshot
Apoptosis in carcinogenesis and chemotherapy : apoptosis in cancer
inferred← citeshttps://doi.org/10.1007/978-1-4020-9597-9_3openalex-snapshot
Apoptosis in Carcinogenesis and Chemoherapy of the Uterine Cervix
inferred← citeshttps://doi.org/10.1007/978-1-4419-1770-6_9openalex-snapshot
The Senescence Secretome and Its Impact on Tumor Suppression and Cancer
inferred← citeshttps://doi.org/10.1007/978-1-4419-8231-5_5openalex-snapshot
The p53-Mdm2 Loop: A Critical Juncture of Stress Response
inferred← citeshttps://doi.org/10.1007/978-1-4419-9863-7_47openalex-snapshot
Cell Cycle Arrest After DNA Damage
inferred← citeshttps://doi.org/10.1007/978-1-59745-200-7_9openalex-snapshot
Control Nodes Linking the Regulatory Networks of the Cell Cycle and Apoptosis
inferred← citeshttps://doi.org/10.1007/978-1-59745-293-9_20openalex-snapshot
Tumor Suppressors p53 and TGFβ Converge to Regulate the Alpha-Fetoprotein Oncodevelopmental Tumor Marker
inferred← citeshttps://doi.org/10.1007/978-1-59745-337-0_13openalex-snapshot
Molecular Targets in Ovarian Cancer and Endometrial Cancer
inferred← citeshttps://doi.org/10.1007/978-1-59745-470-4_8openalex-snapshot
Signaling Pathways in Cancer
inferred← citeshttps://doi.org/10.1007/978-1-59745-510-7_8openalex-snapshot
Medulloblastoma, Primitive Neuroectodermal Tumors, and Pineal Tumors
inferred← citeshttps://doi.org/10.1007/978-1-60327-227-8_24openalex-snapshot
Polycomb Group Protein Homeostasis in Stem Cell Identity – A Hypothetical Appraisal
inferred← citeshttps://doi.org/10.1007/978-1-60327-553-8_14openalex-snapshot
p53 Pathway Alterations in Brain Tumors
inferred← citeshttps://doi.org/10.1007/978-1-61779-407-0_9openalex-snapshot
Targeting Apoptotic Pathways in Melanoma
inferred← citeshttps://doi.org/10.1007/978-1-61779-612-8_9openalex-snapshot
DNA Methylation Changes in Cervical Cancers
inferred← citeshttps://doi.org/10.1007/978-3-030-03952-3_13openalex-snapshot
IER5 Is a p53-Regulated Activator of HSF1 That Contributes to Promotion of Cancer
inferred← citeshttps://doi.org/10.1007/978-3-030-50936-1_47openalex-snapshot
Cell Cycle as a Fault Tolerant Control System
inferred← citeshttps://doi.org/10.1007/978-3-030-53786-9_14openalex-snapshot
The Hallmarks of Pancreatic Cancer
inferred← citeshttps://doi.org/10.1007/978-3-030-73572-2_2openalex-snapshot
Par-4 in Cell Cycle Regulation
inferred← citeshttps://doi.org/10.1007/978-3-319-15916-4_10openalex-snapshot
Cancer—A Story on Fault Propagation in Gene-Cellular Networks
inferred← citeshttps://doi.org/10.1007/978-3-319-26239-0_11openalex-snapshot
Cellular Aging and Tumor Regulation
inferred← citeshttps://doi.org/10.1007/978-3-319-41342-6_10openalex-snapshot
Plumbagin and Its Role in Chronic Diseases
inferred← citeshttps://doi.org/10.1007/978-3-540-34344-8_7openalex-snapshot
Kaposi Sarcoma Herpesvirus-Encoded Interferon Regulator Factors
inferred← citeshttps://doi.org/10.1007/978-3-642-28067-2_7openalex-snapshot
Computational Modeling and Verification of Signaling Pathways in Cancer
inferred← citeshttps://doi.org/10.1007/978-3-7643-8989-5openalex-snapshot
Epigenetics and disease : pharmaceutical opportunities
inferred← citeshttps://doi.org/10.1007/978-3-7643-8989-5_1openalex-snapshot
DNA Methylation and Cancer
inferred← citeshttps://doi.org/10.1007/978-90-481-3415-1_3openalex-snapshot
Chemical Regulation of the Apoptosome: New Alternative Treatments for Cancer
inferred← citeshttps://doi.org/10.1007/978-94-007-0344-5_16openalex-snapshot
Cell Death Signaling in Glioblastoma Multiforme: Role of the Bcl2L12 Oncoprotein
inferred← citeshttps://doi.org/10.1007/978-94-007-4819-4_2openalex-snapshot
System Biology Approach to Study Cancer Related Pathways
inferred← citeshttps://doi.org/10.1007/978-94-017-9211-0_9openalex-snapshot
The p53-Mdm2 Loop: A Critical Juncture of Stress Response
inferred← citeshttps://doi.org/10.1007/978-981-10-6728-0_15openalex-snapshot
Transcription Factors and Colorectal Cancer: An Overview
inferred← citeshttps://doi.org/10.1007/978-981-13-0773-7_8openalex-snapshot
The Development of New Spirooxindoles Targeting the p53–MDM2 Protein-Protein Interactions for Cancer Therapy
inferred← citeshttps://doi.org/10.1007/978-981-13-1477-3_10openalex-snapshot
Natural Lovastatin (NL) as an Anticancer Agent: Docking and Experimental Studies
inferred← citeshttps://doi.org/10.1007/978-981-13-1699-9_5openalex-snapshot
Advances in Senotherapies
inferred← citeshttps://doi.org/10.1007/978-981-16-1247-3_20-1openalex-snapshot
Protective Effect of Quercetin, Luteolin, and Fisetin via Stimulating the p53-Mediated Signaling in Cancer
inferred← citeshttps://doi.org/10.1007/978-981-16-1247-3_275-1openalex-snapshot
Targeting the Transcription Factors of ROS Tumorigenic Pathways as a Therapeutic Strategy in Cancer
inferred← citeshttps://doi.org/10.1007/978-981-16-5422-0_20openalex-snapshot
Protective Effect of Quercetin, Luteolin, and Fisetin via Stimulating the p53-Mediated Signaling in Cancer
inferred← citeshttps://doi.org/10.1007/978-981-16-5422-0_275openalex-snapshot
Targeting the Transcription Factors of ROS Tumorigenic Pathways as a Therapeutic Strategy in Cancer
inferred← citeshttps://doi.org/10.1007/978-981-16-9154-6_46openalex-snapshot
Modeling of p53 Protein Pathway Using Markov Chain Based Probabilistic Boolean Network
inferred← citeshttps://doi.org/10.1007/978-981-99-0749-6_9openalex-snapshot
Role of Nanotechnology in the Development of Photoprotective Formulations
inferred← citeshttps://doi.org/10.1007/s00018-007-7270-0openalex-snapshot
Prolyl isomerase, Pin1: new findings of post-translational modifications and physiological substrates in cancer, asthma and Alzheimer’s disease
inferred← citeshttps://doi.org/10.1007/s00018-016-2358-zopenalex-snapshot
DNA repair mechanisms in embryonic stem cells
inferred← citeshttps://doi.org/10.1007/s00018-020-03612-wopenalex-snapshot
Emerging roles of microRNAs and their implications in uveal melanoma
inferred← citeshttps://doi.org/10.1007/s00018-023-04772-1openalex-snapshot
Single-cell molecular profiling using ex vivo functional readouts fuels precision oncology in glioblastoma
inferred← citeshttps://doi.org/10.1007/s00044-014-1089-7openalex-snapshot
Combination therapy with p53–MDM2 binding inhibitors for malignancies
inferred← citeshttps://doi.org/10.1007/s00115-010-2958-zopenalex-snapshot
Neurologische Komplikationen der neuroonkologischen Therapie
inferred← citeshttps://doi.org/10.1007/s00134-010-2023-1openalex-snapshot
Phosphorylation mechanisms in intensive care medicine
inferred← citeshttps://doi.org/10.1007/s00204-008-0304-zopenalex-snapshot
Intracellular redox status and oxidative stress: implications for cell proliferation, apoptosis, and carcinogenesis
inferred← citeshttps://doi.org/10.1007/s00204-015-1621-7openalex-snapshot
Use of high-throughput RT-qPCR to assess modulations of gene expression profiles related to genomic stability and interactions by cadmium
inferred← citeshttps://doi.org/10.1007/s00277-010-0945-xopenalex-snapshot
Prognostic significance of CD95, P53, and BCL2 expression in extranodal non-Hodgkin’s lymphoma
inferred← citeshttps://doi.org/10.1007/s00277-026-06882-9openalex-snapshot
Prognostic impact of TP53 mutations in diffuse large B-cell lymphoma
inferred← citeshttps://doi.org/10.1007/s00280-015-2791-yopenalex-snapshot
In vitro cytotoxicity and in vivo efficacy, pharmacokinetics, and metabolism of pyrazole-based small molecule inhibitors of Mdm2/4–p53 interaction
inferred← citeshttps://doi.org/10.1007/s00280-020-04046-8openalex-snapshot
The role of deubiquitinating enzymes in cancer drug resistance
inferred← citeshttps://doi.org/10.1007/s00285-014-0837-0openalex-snapshot
Mean field analysis of a spatial stochastic model of a gene regulatory network
inferred← citeshttps://doi.org/10.1007/s00335-025-10134-yopenalex-snapshot
Identification of novel gene expression patterns and pathways involved in PARP-1 inhibitor resistance
inferred← citeshttps://doi.org/10.1007/s00401-018-1842-yopenalex-snapshot
Reconstructing the molecular life history of gliomas
inferred← citeshttps://doi.org/10.1007/s00405-013-2476-2openalex-snapshot
From laryngeal epithelial precursor lesions to squamous carcinoma of the larynx: the role of cell cycle proteins and β-catenin
inferred← citeshttps://doi.org/10.1007/s00411-022-00963-9openalex-snapshot
The radiation adaptive response and priming dose influence: the quantification of the Raper–Yonezawa effect and its three-parameter model for postradiation DNA lesions and mutations
inferred← citeshttps://doi.org/10.1007/s00418-007-0359-6openalex-snapshot
Nucleolus: the fascinating nuclear body
inferred← citeshttps://doi.org/10.1007/s00427-020-00663-8openalex-snapshot
Towards reconstructing the dipteran demise of an ancient essential gene: E3 ubiquitin ligase Murine double minute
inferred← citeshttps://doi.org/10.1007/s00428-010-0931-7openalex-snapshot
High content of Langerhans cells in malignant lymphoma—incidence and significance
inferred← citeshttps://doi.org/10.1007/s00432-009-0605-5openalex-snapshot
Correlation of p53, MDM2 and p14ARF protein expression in human esophageal squamous cell carcinoma
inferred← citeshttps://doi.org/10.1007/s00432-009-0635-zopenalex-snapshot
Splicing variants of the orphan G-protein-coupled receptor GPR56 regulate the activity of transcription factors associated with tumorigenesis
inferred← citeshttps://doi.org/10.1007/s00432-010-0815-xopenalex-snapshot
Decreased nuclear expression and increased cytoplasmic expression of ING5 may be linked to tumorigenesis and progression in human head and neck squamous cell carcinoma
inferred← citeshttps://doi.org/10.1007/s00432-019-02902-6openalex-snapshot
Beyond a chemopreventive reagent, aspirin is a master regulator of the hallmarks of cancer
inferred← citeshttps://doi.org/10.1007/s00467-013-2629-yopenalex-snapshot
The MDM2–p53 pathway: multiple roles in kidney development
inferred← citeshttps://doi.org/10.1007/s00595-026-03280-6openalex-snapshot
RNA-binding motif protein 10 accelerates abdominal aortic aneurysm formation by inducing smooth muscle cell apoptosis
inferred← citeshttps://doi.org/10.1007/s00705-012-1379-7openalex-snapshot
17-allylamino-17-(demethoxy)geldanamycin (17-AAG) is a potent and effective inhibitor of human cytomegalovirus replication in primary fibroblast cells
inferred← citeshttps://doi.org/10.1007/s00775-008-0400-9openalex-snapshot
The ruthenium(II)–arene compound RAPTA-C induces apoptosis in EAC cells through mitochondrial and p53–JNK pathways
inferred← citeshttps://doi.org/10.1007/s00784-024-05984-wopenalex-snapshot
Protein profile at newly restored implants compared to contralateral teeth over 12-months: a pilot study
inferred← citeshttps://doi.org/10.1007/s10126-021-10061-4openalex-snapshot
A Transcriptome Insight During Early Fish Larval Development Followed by Starvation in Seriola rivoliana
inferred← citeshttps://doi.org/10.1007/s10495-006-6316-3openalex-snapshot
Activation of p53 signaling initiates apoptotic death in a cellular model of Parkinson’s disease
inferred← citeshttps://doi.org/10.1007/s10495-007-0104-6openalex-snapshot
New alternative phosphorylation sites on the cyclin dependent kinase 1/cyclin a complex in p53-deficient human cells treated with etoposide: possible association with etoposide-induced apoptosis
inferred← citeshttps://doi.org/10.1007/s10495-009-0327-9openalex-snapshot
The p53 tumor suppressor network in cancer and the therapeutic modulation of cell death
inferred← citeshttps://doi.org/10.1007/s10495-010-0456-1openalex-snapshot
Regulating the genome surveillance system: miRNAs and the p53 super family
inferred← citeshttps://doi.org/10.1007/s10495-010-0548-yopenalex-snapshot
Apoptosis of human fibrosarcoma HT-1080 cells by epigallocatechin-3-O-gallate via induction of p53 and caspases as well as suppression of Bcl-2 and phosphorylated nuclear factor-κB
inferred← citeshttps://doi.org/10.1007/s10495-012-0791-5openalex-snapshot
Tetramethylpyrazine induces G0/G1 cell cycle arrest and stimulates mitochondrial-mediated and caspase-dependent apoptosis through modulating ERK/p53 signaling in hepatic stellate cells in vitro
inferred← citeshttps://doi.org/10.1007/s10495-023-01884-8openalex-snapshot
Oncogenic and immunological roles of RACGAP1 in pan-cancer and its potential value in nasopharyngeal carcinoma
inferred← citeshttps://doi.org/10.1007/s10495-024-01957-2openalex-snapshot
ARTS and small-molecule ARTS mimetics upregulate p53 levels by promoting the degradation of XIAP
inferred← citeshttps://doi.org/10.1007/s10534-020-00269-7openalex-snapshot
Antiproliferative activity exerted by tricyclohexylphosphanegold(I) n-mercaptobenzoate against MCF-7 and A2780 cell lines: the role of p53 signaling pathways
inferred← citeshttps://doi.org/10.1007/s10549-005-9067-xopenalex-snapshot
From genetic abnormality to metastases: murine models of breast cancer and their use in the development of anticancer therapies
inferred← citeshttps://doi.org/10.1007/s10549-009-0557-0openalex-snapshot
Learning to predict relapse in invasive ductal carcinomas based on the subcellular localization of junctional proteins
inferred← citeshttps://doi.org/10.1007/s10549-011-1609-9openalex-snapshot
Pilot and feasibility study: prospective proteomic profiling of mammary epithelial cells from high-risk women provides evidence of activation of pro-survival pathways
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