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The cytochrome bd-type quinol oxidase is important for survival of Mycobacterium smegmatis under peroxide and antibiotic-induced stress
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
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The cytochrome bd respiratory oxygen reductases
inferredcites →https://doi.org/10.1016/j.bbabio.2014.01.016openalex-snapshot
Cytochrome bd oxidase and bacterial tolerance to oxidative and nitrosative stress
inferredcites →https://doi.org/10.1016/j.bbabio.2014.01.022openalex-snapshot
ATP synthase in mycobacteria: Special features and implications for a function as drug target
inferredcites →https://doi.org/10.1016/j.drudis.2012.09.007openalex-snapshot
Advances and strategies in discovery of new antibacterials for combating metabolically resting bacteria
inferredcites →https://doi.org/10.1016/j.febslet.2004.09.013openalex-snapshot
Interaction of the bacterial terminal oxidase cytochrome bd with nitric oxide
inferredcites →https://doi.org/10.1016/j.febslet.2013.05.047openalex-snapshot
Cytochrome bd oxidase from Escherichia coli displays high catalase activity: An additional defense against oxidative stress
inferredcites →https://doi.org/10.1016/s0021-9258(17)43305-9openalex-snapshot
Terminal oxidases of Escherichia coli aerobic respiratory chain. II. Purification and properties of cytochrome b558-d complex from cells grown with limited oxygen and evidence of branched electron-carrying systems.
inferredcites →https://doi.org/10.1021/bi00003a044openalex-snapshot
New inhibitors of the quinol oxidation sites of bacterial cytochromes bo and bd
inferredcites →https://doi.org/10.1021/bi00230a019openalex-snapshot
Properties of the two terminal oxidases of Escherichia coli
inferredcites →https://doi.org/10.1021/jm201608gopenalex-snapshot
Discovery of Selective Menaquinone Biosynthesis Inhibitors against Mycobacterium tuberculosis
inferredcites →https://doi.org/10.1023/a:1002779201379openalex-snapshot
Roles of respiratory oxidases in protecting Escherichia coli K12 from oxidative stress
inferredcites →https://doi.org/10.1038/nature02285openalex-snapshot
The strict anaerobe Bacteroides fragilis grows in and benefits from nanomolar concentrations of oxygen
inferredcites →https://doi.org/10.1038/nature09657openalex-snapshot
The challenge of new drug discovery for tuberculosis
inferredcites →https://doi.org/10.1038/nchembio.135openalex-snapshot
Cytochrome bd confers nitric oxide resistance to Escherichia coli
inferredcites →https://doi.org/10.1038/nchembio884openalex-snapshot
Diarylquinolines target subunit c of mycobacterial ATP synthase
inferredcites →https://doi.org/10.1038/ncomms4369openalex-snapshot
Delayed bactericidal response of Mycobacterium tuberculosis to bedaquiline involves remodelling of bacterial metabolism
inferredcites →https://doi.org/10.1038/nm.3262openalex-snapshot
Discovery of Q203, a potent clinical candidate for the treatment of tuberculosis
inferredcites →https://doi.org/10.1038/nrmicro2236openalex-snapshot
The spectrum of latent tuberculosis: rethinking the biology and intervention strategies
inferredcites →https://doi.org/10.1038/nrmicro2474openalex-snapshot
Targeting bacterial membrane function: an underexploited mechanism for treating persistent infections
inferredcites →https://doi.org/10.1038/nrmicro2797openalex-snapshot
Global tuberculosis control: lessons learnt and future prospects
inferredcites →https://doi.org/10.1038/nrmicro3200openalex-snapshot
The path of anti-tuberculosis drugs: from blood to lesions to mycobacterial cells
inferredcites →https://doi.org/10.1073/pnas.0500469102openalex-snapshot
Inhibitors of type II NADH:menaquinone oxidoreductase represent a class of antitubercular drugs
inferredcites →https://doi.org/10.1073/pnas.0507850102openalex-snapshot
Changes in energy metabolism of Mycobacterium tuberculosis in mouse lung and under in vitro conditions affecting aerobic respiration
inferredcites →https://doi.org/10.1073/pnas.0711697105openalex-snapshot
The protonmotive force is required for maintaining ATP homeostasis and viability of hypoxic, nonreplicating Mycobacterium tuberculosis
inferredcites →https://doi.org/10.1074/jbc.m110.200501openalex-snapshot
Reduction of Clofazimine by Mycobacterial Type 2 NADH:Quinone Oxidoreductase
inferredcites →https://doi.org/10.1074/jbc.m406796200openalex-snapshot
The Transcriptional Responses of Mycobacterium tuberculosis to Inhibitors of Metabolism
inferredcites →https://doi.org/10.1093/jac/dks483openalex-snapshot
Antitubercular pharmacodynamics of phenothiazines
inferredcites →https://doi.org/10.1099/00221287-143-8-2673openalex-snapshot
The Klebsiella pneumoniae cytochrome bd’ terminal oxidase complex and its role in microaerobic nitrogen fixation
inferredcites →https://doi.org/10.1099/00221287-144-12-3297openalex-snapshot
A factor produced by Escherichia coli K-12 inhibits the growth of E. coli mutants defective in the cytochrome bd quinol oxidase complex: enterochelin rediscovered
inferredcites →https://doi.org/10.1111/j.1365-2958.2005.04555.xopenalex-snapshot
Respiration metabolism of Group B Streptococcus is activated by environmental haem and quinone and contributes to virulence
inferredcites →https://doi.org/10.1111/j.1574-6968.2010.01959.xopenalex-snapshot
Respiratory ATP synthesis: the new generation of mycobacterial drug targets?
inferredcites →https://doi.org/10.1111/j.1574-6968.2010.02123.xopenalex-snapshot
ATP synthase in slow- and fast-growing mycobacteria is active in ATP synthesis and blocked in ATP hydrolysis direction
inferredcites →https://doi.org/10.1126/science.1106753openalex-snapshot
A Diarylquinoline Drug Active on the ATP Synthase of Mycobacterium tuberculosis
inferredcites →https://doi.org/10.1126/science.339.6116.130openalex-snapshot
Approval of Novel TB Drug Celebrated—With Restraint
inferredcites →https://doi.org/10.1128/aac.00507-11openalex-snapshot
Pyrazinoic Acid Decreases the Proton Motive Force, Respiratory ATP Synthesis Activity, and Cellular ATP Levels
inferredcites →https://doi.org/10.1128/aac.00689-09openalex-snapshot
ATP Synthase Inhibition of Mycobacterium avium Is Not Bactericidal
inferredcites →https://doi.org/10.1128/aac.01393-08openalex-snapshot
Selectivity of TMC207 towards Mycobacterial ATP Synthase Compared with That towards the Eukaryotic Homologue
inferredcites →https://doi.org/10.1128/aac.02293-13openalex-snapshot
Energy Metabolism and Drug Efflux in Mycobacterium tuberculosis
inferredcites →https://doi.org/10.1128/aac.03486-14openalex-snapshot
Respiratory Flexibility in Response to Inhibition of Cytochrome c Oxidase in Mycobacterium tuberculosis
inferredcites →https://doi.org/10.1128/iai.71.6.3392-3401.2003openalex-snapshot
Contribution of Proton-Translocating Proteins to the Virulence of Salmonella enterica Serovars Typhimurium, Gallinarum, and Dublin in Chickens and Mice
inferredcites →https://doi.org/10.1128/jb.181.4.1229-1237.1999openalex-snapshot
Impact of either Elevated or Decreased Levels of Cytochrome bd Expression on Shigella flexneri Virulence
inferredcites →https://doi.org/10.1128/jb.183.24.7076-7086.2001openalex-snapshot
Characterization of the cydAB -Encoded Cytochrome bd Oxidase from Mycobacterium smegmatis
inferredcites →https://doi.org/10.1128/jb.183.8.2454-2462.2001openalex-snapshot
Interruption of thecydBLocus inBrucella abortusAttenuates Intracellular Survival and Virulence in the Mouse Model of Infection
inferredcites →https://doi.org/10.1128/jb.187.18.6300-6308.2005openalex-snapshot
Function of the Cytochrome bc 1 - aa 3 Branch of the Respiratory Network in Mycobacteria and Network Adaptation Occurring in Response to Its Disruption
inferredcites →https://doi.org/10.1128/mbio.00475-13openalex-snapshot
Perturbation of Cytochrome c Maturation Reveals Adaptability of the Respiratory Chain in Mycobacterium tuberculosis
inferredcites →https://doi.org/10.1128/mbio.01006-13openalex-snapshot
Cytochrome bd Oxidase and Hydrogen Peroxide Resistance in Mycobacterium tuberculosis
inferredcites →https://doi.org/10.1128/mbio.01275-14openalex-snapshot
A Mycobacterium tuberculosis Cytochrome bd Oxidase Mutant Is Hypersensitive to Bedaquiline
inferredcites →https://doi.org/10.1128/microbiolspec.mgm2-0015-2013openalex-snapshot
Energetics of Respiration and Oxidative Phosphorylation in Mycobacteria
inferredcites →https://doi.org/10.1371/journal.pone.0023575openalex-snapshot
Probing the Interaction of the Diarylquinoline TMC207 with Its Target Mycobacterial ATP Synthase
inferredcites →https://doi.org/10.1371/journal.pone.0052951openalex-snapshot
Identification of Novel Imidazo[1,2-a]pyridine Inhibitors Targeting M. tuberculosis QcrB
inferredcites →https://doi.org/10.2217/fmb.14.60openalex-snapshot
Drug Susceptibility Testing of Nontuberculous Mycobacteria
inferredcites →https://doi.org/10.3762/bjoc.9.176openalex-snapshot
Synthesis and biological activities of the respiratory chain inhibitor aurachin D and new ring versus chain analogues
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
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New Synergistic Benzoquinone Scaffolds as Inhibitors of Mycobacterial Cytochrome Bc1 Complex to Treat Multi-Drug Resistant Tuberculosis
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AscF in the mycobacterial CIII – CIV supercomplex lacks metal and nucleotide binding but links malate oxidation to respiration
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Structural Simplification of Bedaquiline: the Discovery of 3‐(4‐(N,N‐Dimethylaminomethyl)phenyl)quinoline‐Derived Antitubercular Lead Compounds
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Multiomics Integration of Tuberculosis Pathogenesis
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Multidrug-resistant tuberculosis: a comprehensive review of pathogenesis, drug resistance, current treatment and future prospects
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Targeting the menaquinol binding loop of mycobacterial cytochrome bd oxidase
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Targeting the cytochrome bc1 complex for drug development in M. tuberculosis: review
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The carboxy-terminal insert in the Q-loop is needed for functionality of Escherichia coli cytochrome bd-I
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pH-dependent kinetics of NO release from E. coli bd-I and bd-II oxidase reveals involvement of Asp/Glu58B
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New antituberculosis drugs targeting the respiratory chain
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Tuberculosis: Past, present and future of the treatment and drug discovery research
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Design, synthesis and biological evaluation of (Quinazoline 4-yloxy)acetamide and (4-oxoquinazoline-3(4H)-yl)acetamide derivatives as inhibitors of Mycobacterium tuberculosis bd oxidase
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New synergistic benzoquinone scaffolds as inhibitors of mycobacterial cytochrome bc1 complex to treat multi-drug resistant tuberculosis
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Menaquinone-specific turnover by Mycobacterium tuberculosis cytochrome bd is redox regulated by the Q-loop disulfide bond
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Response of Bacillus velezensis 83 to interaction with Colletotrichum gloeosporioides resembles a Greek phalanx-style formation: A stress resistant phenotype with antibiosis capacity
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Redox-dependent condensation of the mycobacterial nucleoid by WhiB4
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Screening of antitubercular compound library identifies novel ATP synthase inhibitors of Mycobacterium tuberculosis
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Features and Functional Importance of Key Residues of the Mycobacterium tuberculosis Cytochrome bd Oxidase
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Synthesis and Biological Evaluation of Aurachin D Analogues as Inhibitors of Mycobacterium tuberculosis Cytochrome bd Oxidase
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Network analysis identifies Rv0324 and Rv0880 as regulators of bedaquiline tolerance in Mycobacterium tuberculosis
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The cryo-EM structure of the bd oxidase from M. tuberculosis reveals a unique structural framework and enables rational drug design to combat TB
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The anti-mycobacterial activity of the cytochrome bcc inhibitor Q203 can be enhanced by small-molecule inhibition of cytochrome bd
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Facile metabolic reprogramming distinguishes mycobacterial adaptation to hypoxia and starvation: ketosis drives starvation-induced persistence in M. bovis BCG
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Cytochrome bd Displays Significant Quinol Peroxidase Activity
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Mycobacteriophage SWU1 gp39 can potentiate multiple antibiotics against Mycobacterium via altering the cell wall permeability
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Two uptake hydrogenases differentially interact with the aerobic respiratory chain during mycobacterial growth and persistence
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The extracytoplasmic function σ factor σC regulates expression of a branched quinol oxidation pathway in Corynebacterium glutamicum
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Isoniazid Bactericidal Activity Involves Electron Transport Chain Perturbation
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Iron-Induced Respiration Promotes Antibiotic Resistance in Actinomycete Bacteria
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An exacerbated phosphate starvation response triggers Mycobacterium tuberculosis glycerol utilization at acidic pH
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Mycobacteria Tolerate Carbon Monoxide by Remodeling Their Respiratory Chain
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Preparations of Terminal Oxidase Cytochrome bd-II Isolated from Escherichia coli Reveal Significant Hydrogen Peroxide Scavenging Activity
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Cytochrome bd as Antioxidant Redox Enzyme
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Screening of Antitubercular Compound Library Identifies Inhibitors of Mur Enzymes in Mycobacterium tuberculosis
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Biocatalytic production of the antibiotic aurachin D in Escherichia coli
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Identification of differentially expressed genes for Pseudomonas sp. Cr13 stimulated by hexavalent chromium
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Host immunity increases Mycobacterium tuberculosis reliance on cytochrome bd oxidase
inferred← citeshttps://doi.org/10.15252/emmm.202013207openalex-snapshot
Dual inhibition of the terminal oxidases eradicates antibiotic‐tolerant Mycobacterium tuberculosis
inferred← citeshttps://doi.org/10.21203/rs.3.rs-3193999/v1openalex-snapshot
Facile metabolic reprogramming distinguishes mycobacterial adaptation to hypoxia and starvation: The role of ketosis in starvation-induced persistence
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The Transcription Factor Rv1453 Regulates the Expression of qor and Confers Resistant to Clofazimine in Mycobacterium tuberculosis
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Characterization of regulatory central stalk epitopes of mycobacterial- and acetogen F-ATP synthases
inferred← citeshttps://doi.org/10.32657/10356/152336openalex-snapshot
Exploiting reductive evolution in Mycobacterium ulcerans to develop a single-dose cure for Buruli ulcer
inferred← citeshttps://doi.org/10.32657/10356/155550openalex-snapshot
Suffocating tuberculosis : oxidative phosphorylation as a target space for the development of next generation anti-tuberculosis drugs
inferred← citeshttps://doi.org/10.32657/10356/155733openalex-snapshot
Evaluating the attractiveness of the terminal oxidases as drug targets in mycobacterium abscessus
inferred← citeshttps://doi.org/10.3389/fcimb.2020.589318openalex-snapshot
Terminal Respiratory Oxidases: A Targetables Vulnerability of Mycobacterial Bioenergetics?
inferred← citeshttps://doi.org/10.3389/fcimb.2020.611683openalex-snapshot
Bioenergetic Inhibitors: Antibiotic Efficacy and Mechanisms of Action in Mycobacterium tuberculosis
inferred← citeshttps://doi.org/10.3389/fcimb.2022.980844openalex-snapshot
Uncovering interactions between mycobacterial respiratory complexes to target drug-resistant Mycobacterium tuberculosis
inferred← citeshttps://doi.org/10.3389/fmicb.2018.02895openalex-snapshot
Transcriptional Approach for Decoding the Mechanism of rpoC Compensatory Mutations for the Fitness Cost in Rifampicin-Resistant Mycobacterium tuberculosis
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Cpn60.1 (GroEL1) Contributes to Mycobacterial Crabtree Effect: Implications for Biofilm Formation
inferred← citeshttps://doi.org/10.3389/fmicb.2024.1479714openalex-snapshot
The respiratory chain of Klebsiella aerogenes in urine-like conditions: critical roles of NDH-2 and bd-terminal oxidases
inferred← citeshttps://doi.org/10.3389/fmicb.2025.1539139openalex-snapshot
Mycobactin and clofazimine activity are negatively correlated in mycobacteria
inferred← citeshttps://doi.org/10.3389/fphys.2022.874321openalex-snapshot
Thriving in Oxygen While Preventing ROS Overproduction: No Two Systems Are Created Equal
inferred← citeshttps://doi.org/10.3390/antibiotics12061067openalex-snapshot
Aurachins, Bacterial Antibiotics Interfering with Electron Transport Processes
inferred← citeshttps://doi.org/10.3390/antiox10060839openalex-snapshot
ROS Defense Systems and Terminal Oxidases in Bacteria
inferred← citeshttps://doi.org/10.3390/antiox15070859openalex-snapshot
Effect of Ammonia on Escherichia coli Growth and Aerobic Respiration: The Role of Cytochrome bd-II
inferred← citeshttps://doi.org/10.3390/app10072339openalex-snapshot
Oxidative Phosphorylation—an Update on a New, Essential Target Space for Drug Discovery in Mycobacterium tuberculosis
inferred← citeshttps://doi.org/10.3390/ijms23063166openalex-snapshot
Recent Advances in Structural Studies of Cytochrome bd and Its Potential Application as a Drug Target
inferred← citeshttps://doi.org/10.3390/ijms23137321openalex-snapshot
Bioenergetics and Reactive Nitrogen Species in Bacteria
inferred← citeshttps://doi.org/10.3390/ijms231810331openalex-snapshot
Response of Mycobacterium smegmatis to the Cytochrome bcc Inhibitor Q203
inferred← citeshttps://doi.org/10.3390/pathogens7010024openalex-snapshot
Bioenergetics of Mycobacterium: An Emerging Landscape for Drug Discovery
inferred← citeshttps://doi.org/10.3390/ph13090227openalex-snapshot
SAR Analysis of Small Molecules Interfering with Energy-Metabolism in Mycobacterium tuberculosis
inferred← citeshttps://doi.org/10.4155/ppa-2020-0027openalex-snapshot
Patent Highlights June–July 2020
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Discovery of a novel chemotype targeting Mycobacterium tuberculosis cytochrome bd through rapid screening and structural elucidation
inferred← citeshttps://doi.org/10.64898/2026.08.30.748090openalex-snapshot
Defining the role of aerobic respiration in the metabolism and bioenergetics of Enterococcus faecalis
inferred← citeshttps://doi.org/10.7554/elife.25624openalex-snapshot
Efficacy of β-lactam/β-lactamase inhibitor combination is linked to WhiB4-mediated changes in redox physiology of Mycobacterium tuberculosis
inferred← citeshttps://doi.org/10.7554/elife.25624.037openalex-snapshot
Author response: Efficacy of β-lactam/β-lactamase inhibitor combination is linked to WhiB4-mediated changes in redox physiology of Mycobacterium tuberculosis
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