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The identification of an integral membrane, cytochrome c urate oxidase completes the catalytic repertoire of a therapeutic enzyme

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/14651858.cd006945.pub3openalex-snapshot

Urate oxidase for the prevention and treatment of tumour lysis syndrome in children with cancer

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Urate oxidase for the prevention and treatment of tumour lysis syndrome in children with cancer

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Frequent item set mining

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Genes for a second terminal oxidase in Bradyrhizobium japonicum

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Chromosomal location of genes participating in the degradation of purines in Pseudomonas aeruginosa

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A method for the detection of superoxide in biological systems

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Purine degradation in Pseudomonas aeruginosa and Pseudomonas testosteroni

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Guided by electrostatics, a textbook protein comes of age

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Purine utilization proteins in the Eurotiales: Cellular compartmentalization, phylogenetic conservation and divergence

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A phylum level perspective on bacterial cell envelope architecture

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A novel hydrophobic diheme c -type cytochrome. Purification from Corynebacterium glutamicum and analysis of the QcrCBA operon encoding three subunit proteins of a putative cytochrome reductase complex 1The nucleotide sequences reported in this paper have been submitted to the DDBJ/GenBank/EMBL…

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Quantitative Aspects of the Production of Superoxide Anion Radical by Milk Xanthine Oxidase

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[13] Catalase in vitro

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Crystal structure of the di-haem cytochrome c peroxidase from Pseudomonas aeruginosa

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Crystal Structures of Cytochrome cL and Methanol Dehydrogenase from Hyphomicrobium denitrificans: Structural and Mechanistic Insights into Interactions between the Two Proteins,

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Structural and Mechanistic Studies of HpxO, a Novel Flavin Adenine Dinucleotide-Dependent Urate Oxidase from Klebsiella pneumoniae

inferredcites →https://doi.org/10.1021/bi4010107openalex-snapshot

Gene Context Analysis Reveals Functional Divergence between Hypothetically Equivalent Enzymes of the Purine–Ureide Pathway

inferredcites →https://doi.org/10.1021/bi900160bopenalex-snapshot

Biochemical Characterization of the HpxO Enzyme from Klebsiella pneumoniae, a Novel FAD-Dependent Urate Oxidase

inferredcites →https://doi.org/10.1021/ja970375topenalex-snapshot

Identification of the True Product of the Urate Oxidase Reaction

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Systematic discovery of analogous enzymes in thiamin biosynthesis

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Ureide catabolism in Arabidopsis thaliana and Escherichia coli

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Completing the uric acid degradation pathway through phylogenetic comparison of whole genomes

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Update on gout: new therapeutic strategies and options

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Absolute stereochemistry and preferred conformations of urate degradation intermediates from computed and experimental circular dichroism spectra

inferredcites →https://doi.org/10.1039/c6ob90042aopenalex-snapshot

Correction: Absolute stereochemistry and preferred conformations of urate degradation intermediates from computed and experimental circular dichroism spectra

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Properties of azide-catalase

inferredcites →https://doi.org/10.1053/j.ajkd.2008.09.011openalex-snapshot

Efficacy of Rasburicase in Hyperuricemia Secondary to Lesch-Nyhan Syndrome

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Treating gout with pegloticase, a PEGylated urate oxidase, provides insight into the importance of uric acid as an antioxidant in vivo

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Deficiency of 5-hydroxyisourate hydrolase causes hepatomegaly and hepatocellular carcinoma in mice

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Evolutionary history and metabolic insights of ancient mammalian uricases

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Primary structure of the soybean nodulin-35 gene encoding uricase II localized in the peroxisomes of uninfected cells of nodules

inferredcites →https://doi.org/10.1073/pnas.96.11.6462openalex-snapshot

Heme transfer to the heme chaperone CcmE during cytochrome c maturation requires the CcmC protein, which may function independently of the ABC-transporter CcmAB

inferredcites →https://doi.org/10.1073/pnas.96.8.4285openalex-snapshot

Assigning protein functions by comparative genome analysis: Protein phylogenetic profiles

inferredcites →https://doi.org/10.1074/jbc.270.15.8610openalex-snapshot

Genetic and Molecular Characterization of a Gene Encoding a Wide Specificity Purine Permease of Aspergillus nidulans Reveals a Novel Family of Transporters Conserved in Prokaryotes and Eukaryotes

inferredcites →https://doi.org/10.1093/bioinformatics/bti125openalex-snapshot

Protein homology detection by HMM–HMM comparison

inferredcites →https://doi.org/10.1093/bioinformatics/bts184openalex-snapshot

ape 3.0: New tools for distance-based phylogenetics and evolutionary analysis in R

inferredcites →https://doi.org/10.1093/bioinformatics/btt607openalex-snapshot

Protter: interactive protein feature visualization and integration with experimental proteomic data

inferredcites →https://doi.org/10.1093/jb/mvt019openalex-snapshot

Cyanide-insensitive quinol oxidase (CIO) from Gluconobacter oxydans is a unique terminal oxidase subfamily of cytochrome bd

inferredcites →https://doi.org/10.1093/nar/30.7.1575openalex-snapshot

An efficient algorithm for large-scale detection of protein families

inferredcites →https://doi.org/10.1093/nar/gkg034openalex-snapshot

STRING: a database of predicted functional associations between proteins

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Advantages of combined transmembrane topology and signal peptide prediction--the Phobius web server

inferredcites →https://doi.org/10.1093/nar/gkp363openalex-snapshot

TOPCONS: consensus prediction of membrane protein topology

inferredcites →https://doi.org/10.1093/nar/gkq399openalex-snapshot

ConSurf 2010: calculating evolutionary conservation in sequence and structure of proteins and nucleic acids

inferredcites →https://doi.org/10.1093/nar/gkt1223openalex-snapshot

Pfam: the protein families database

inferredcites →https://doi.org/10.1093/nar/gku316openalex-snapshot

Deciphering key features in protein structures with the new ENDscript server

inferredcites →https://doi.org/10.1101/gr.8.8.779openalex-snapshot

Analogous Enzymes: Independent Inventions in Enzyme Evolution

inferredcites →https://doi.org/10.1105/tpc.114.124008openalex-snapshot

Uric Acid Accumulation in an Arabidopsis Urate Oxidase Mutant Impairs Seedling Establishment by Blocking Peroxisome Maintenance

inferredcites →https://doi.org/10.1107/s0907444903029718openalex-snapshot

Complexed and ligand-free high-resolution structures of urate oxidase (Uox) fromAspergillus flavus: a reassignment of the active-site binding mode

inferredcites →https://doi.org/10.1111/j.1758-2229.2012.00390.xopenalex-snapshot

Microbial urate catabolism: characterization of HpyO , a non‐homologous isofunctional isoform of the flavoprotein urate hydroxylase HpxO

inferredcites →https://doi.org/10.1126/science.1066803openalex-snapshot

Genome Sequence of the Plant Pathogen and Biotechnology Agent Agrobacterium tumefaciens C58

inferredcites →https://doi.org/10.1126/science.1103330openalex-snapshot

Use of Logic Relationships to Decipher Protein Network Organization

inferredcites →https://doi.org/10.1126/science.278.5338.631openalex-snapshot

A Genomic Perspective on Protein Families

inferredcites →https://doi.org/10.1128/aem.01098-08openalex-snapshot

Broad-Host-Range Expression Vectors with Tightly Regulated Promoters and Their Use To Examine the Influence of TraR and TraM Expression on Ti Plasmid Quorum Sensing

inferredcites →https://doi.org/10.1128/br.40.2.403-468.1976openalex-snapshot

Degradation of purines and pyrimidines by microorganisms

inferredcites →https://doi.org/10.1128/jb.01022-08openalex-snapshot

The hpx Genetic System for Hypoxanthine Assimilation as a Nitrogen Source in Klebsiella pneumoniae : Gene Organization and Transcriptional Regulation

inferredcites →https://doi.org/10.1128/jb.01281-08openalex-snapshot

Purine Utilization byKlebsiella oxytocaM5al: Genes for Ring-Oxidizing and -Opening Enzymes

inferredcites →https://doi.org/10.1128/jb.02176-14openalex-snapshot

Enzymatic Characterization and In Vivo Function of Five Terminal Oxidases in Pseudomonas aeruginosa

inferredcites →https://doi.org/10.1371/journal.pcbi.1002144openalex-snapshot

A Peptide Filtering Relation Quantifies MHC Class I Peptide Optimization

inferredcites →https://doi.org/10.1371/journal.pcbi.1002195openalex-snapshot

Accelerated Profile HMM Searches

inferredcites →https://doi.org/10.1385/cbb:32:1-3:123openalex-snapshot

Evolution of Urate-Degrading Enzymes in Animal Peroxisomes

inferredcites →https://doi.org/10.2306/scienceasia1513-1874.2005.31.349openalex-snapshot

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Bio Processes Generating Micp and Identification of the Functional Bio Processes During Soil Modification

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Ureide metabolism in plant-associated bacteria: purine plant-bacteria interactive scenarios under nitrogen deficiency

inferred← citeshttps://doi.org/10.1007/s12010-023-04819-wopenalex-snapshot

Targeting Efficient Features of Urate Oxidase to Increase Its Solubility

inferred← citeshttps://doi.org/10.1016/j.chembiol.2023.04.008openalex-snapshot

Anaerobic purinolytic enzymes enable dietary purine clearance by engineered gut bacteria

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Novel FAD-dependent uricase produced by food-sourced Priestia megaterium and activity assessment using hyperuricemia Caenorhabditis elegans

inferred← citeshttps://doi.org/10.1016/j.jconrel.2017.04.009openalex-snapshot

Bioengineered robust hybrid hydrogels enrich the stability and efficacy of biological drugs

inferred← citeshttps://doi.org/10.1016/j.vascn.2020.106681openalex-snapshot

A natural complex product Yaocha reduces uric acid level in a live zebrafish model

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Integrated Proteomics and Metabolomics Reveal the Mechanism of Nephrotoxicity Induced by Triptolide

inferred← citeshttps://doi.org/10.1021/acssynbio.4c00831openalex-snapshot

Systematic Engineering for Efficient Uric Acid-Degrading Activity in Probiotic Yeast Saccharomyces boulardii

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Multiphase Radical Chemical Processes Induced by Air Pollutants and the Associated Health Effects

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Herbivorous turtle ants obtain essential nutrients from a conserved nitrogen-recycling gut microbiome

inferred← citeshttps://doi.org/10.1038/srep38302openalex-snapshot

Catalysis and Structure of Zebrafish Urate Oxidase Provide Insights into the Origin of Hyperuricemia in Hominoids

inferred← citeshttps://doi.org/10.1093/femsec/fiac068openalex-snapshot

Turtle ants harbor metabolically versatile microbiomes with conserved functions across development and phylogeny

inferred← citeshttps://doi.org/10.1093/lifemeta/loaf031openalex-snapshot

A reductive uric acid degradation pathway in anaerobic bacteria

inferred← citeshttps://doi.org/10.1101/2021.09.08.459499openalex-snapshot

In their sister’s footsteps: Taxonomic divergence obscures substantial functional overlap among the metabolically diverse symbiotic gut communities of adult and larval turtle ants

inferred← citeshttps://doi.org/10.1111/1462-2920.16088openalex-snapshot

Regulation of uric acid and glyoxylate metabolism by UgmR protein in Pseudomonas aeruginosa

inferred← citeshttps://doi.org/10.1111/febs.17332openalex-snapshot

Paradigms of convergent evolution in enzymes

inferred← citeshttps://doi.org/10.1111/mmi.70002openalex-snapshot

In Hyphomicrobium denitrificans Two Related Sulfane‐Sulfur Responsive Transcriptional Repressors Regulate Thiosulfate Oxidation and Have a Deep Impact on Nitrate Respiration and Anaerobic Biosyntheses

inferred← citeshttps://doi.org/10.1128/jb.00041-22openalex-snapshot

A Functional Analysis of the Purine Salvage Pathway in Acetobacter fabarum

inferred← citeshttps://doi.org/10.1128/jb.00573-18openalex-snapshot

Identification of a Formate-Dependent Uric Acid Degradation Pathway in Escherichia coli

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Status, challenges, and prospects of artificial intelligence application in gout diagnosis and treatment, drug research and development, and disease monitoring

inferred← citeshttps://doi.org/10.3892/mmr.2018.8700openalex-snapshot

Protective effects of tetrahydropalmatine against ketamine-induced learning and memory injury via antioxidative, anti-inflammatory and anti-apoptotic mechanisms in mice

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