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Hepatocellular carcinoma: thyroid hormone promotes tumorigenicity through inducing cancer stem-like cell self-renewal
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1002/hep.24075openalex-snapshot
Sorafenib suppresses postsurgical recurrence and metastasis of hepatocellular carcinoma in an orthotopic mouse model
inferredcites →https://doi.org/10.1007/s00018-012-1146-7openalex-snapshot
Thyroid hormone actions in liver cancer
inferredcites →https://doi.org/10.1016/j.bbagen.2012.07.014openalex-snapshot
Thyroid hormone's action on progenitor/stem cell biology: New challenge for a classic hormone?
inferredcites →https://doi.org/10.1016/j.cell.2008.03.027openalex-snapshot
The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells
inferredcites →https://doi.org/10.1016/j.cell.2011.02.013openalex-snapshot
Hallmarks of Cancer: The Next Generation
inferredcites →https://doi.org/10.1038/nature02060openalex-snapshot
Bmi-1 dependence distinguishes neural stem cell self-renewal from progenitor proliferation
inferredcites →https://doi.org/10.1038/nature14326openalex-snapshot
PPAR-α and glucocorticoid receptor synergize to promote erythroid progenitor self-renewal
inferredcites →https://doi.org/10.1038/nature15260openalex-snapshot
Single-cell analysis reveals a stem-cell program in human metastatic breast cancer cells
inferredcites →https://doi.org/10.1038/ncomms3299openalex-snapshot
NF-κB non-cell-autonomously regulates cancer stem cell populations in the basal-like breast cancer subtype
inferredcites →https://doi.org/10.1038/nrgastro.2010.213openalex-snapshot
NF-κB in the liver—linking injury, fibrosis and hepatocellular carcinoma
inferredcites →https://doi.org/10.1038/onc.2009.265openalex-snapshot
Thyroid hormone receptor mutants implicated in human hepatocellular carcinoma display an altered target gene repertoire
inferredcites →https://doi.org/10.1038/sj.bjc.6605689openalex-snapshot
Characterisation of a novel cell line (CSQT-2) with high metastatic activity derived from portal vein tumour thrombus of hepatocellular carcinoma
inferredcites →https://doi.org/10.1038/sj.onc.1209935openalex-snapshot
Cross-talk between nuclear receptors and nuclear factor κB
inferredcites →https://doi.org/10.1053/j.gastro.2004.09.036openalex-snapshot
Hepatocellular carcinoma: Current management and future trends
inferredcites →https://doi.org/10.1053/j.gastro.2008.12.004openalex-snapshot
EpCAM-Positive Hepatocellular Carcinoma Cells Are Tumor-Initiating Cells With Stem/Progenitor Cell Features
inferredcites →https://doi.org/10.1073/pnas.0702759104openalex-snapshot
Targeting thyroid hormone receptor-β agonists to the liver reduces cholesterol and triglycerides and improves the therapeutic index
inferredcites →https://doi.org/10.1073/pnas.1007863107openalex-snapshot
Estrogen expands breast cancer stem-like cells through paracrine FGF/Tbx3 signaling
inferredcites →https://doi.org/10.1097/med.0b013e32833d9710openalex-snapshot
Thyroid hormones and cancer: clinical studies of hypothyroidism in oncology
inferredcites →https://doi.org/10.1152/physrev.2001.81.3.1269openalex-snapshot
Nuclear Hormone Receptors and Gene Expression
inferredcites →https://doi.org/10.1158/1078-0432.ccr-14-0122openalex-snapshot
Intratumor Heterogeneity in Hepatocellular Carcinoma
inferredcites →https://doi.org/10.1158/2159-8290.cd-13-0945openalex-snapshot
Epithelial-to-Mesenchymal Transition Activates PERK–eIF2α and Sensitizes Cells to Endoplasmic Reticulum Stress
inferredcites →https://doi.org/10.1159/000479571openalex-snapshot
Induction of the Vitamin D Receptor Attenuates Autophagy Dysfunction-Mediated Cell Death Following Traumatic Brain Injury
inferredcites →https://doi.org/10.1172/jci200420800openalex-snapshot
Bmi1, stem cells, and senescence regulation
inferredcites →https://doi.org/10.1172/jci60047openalex-snapshot
Mechanisms of thyroid hormone action
inferredcites →https://doi.org/10.1172/jci66024openalex-snapshot
Cancer stem cells in the development of liver cancer
inferredcites →https://doi.org/10.1186/bcr2886openalex-snapshot
NF-κB, stem cells and breast cancer: the links get stronger
inferredcites →https://doi.org/10.1200/jco.2008.20.7753openalex-snapshot
Hepatocellular Carcinoma Incidence, Mortality, and Survival Trends in the United States From 1975 to 2005
inferredcites →https://doi.org/10.1210/mend.12.1.0043openalex-snapshot
TLS (Translocated-in-Liposarcoma) Is a High-Affinity Interactor for Steroid, Thyroid Hormone, and Retinoid Receptors
inferredcites →https://doi.org/10.1523/jneurosci.0968-09.2009openalex-snapshot
BMI1 Sustains Human Glioblastoma Multiforme Stem Cell Renewal
inferredcites →https://doi.org/10.1677/jme.1.01911openalex-snapshot
Mediation of the inhibitory effect of thyroid hormone on proliferation of hepatoma cells by transforming growth factor-beta
inferredcites →https://doi.org/10.18632/oncoscience.121openalex-snapshot
TR4 nuclear receptor enhances prostate cancer initiation via altering the stem cell population and EMT signals in the PPARG-deleted prostate cells
inferredcites →https://doi.org/10.18632/oncotarget.3113openalex-snapshot
Osteopontin promotes a cancer stem cell-like phenotype in hepatocellular carcinoma cells via an integrin-NF-κB–HIF-1α pathway
inferredcites →https://doi.org/10.3858/emm.2009.41.8.091openalex-snapshot
Nuclear receptor regulation of stemness and stem cell differentiation
inferredcites →https://doi.org/10.4161/cc.10.13.16348openalex-snapshot
Inhibition of Aurora-A kinase induces cell cycle arrest in epithelial ovarian cancer stem cells by affecting NFĸB pathway
inferredcites →https://doi.org/10.4161/cc.8.1.7533openalex-snapshot
Molecular phenotyping of human ovarian cancer stem cells unravels the mechanisms for repair and chemoresistance
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
inferred← citeshttps://doi.org/10.2139/ssrn.4505322openalex-extracted
Graves' Disease Reduces the Risk of Hepatocellular Carcinoma: A Mendelian Randomization Study
inferred← citeshttps://doi.org/10.1002/ijc.33813openalex-snapshot
Hypothyroidism is a predictive factor of superior antitumour efficacy of programmed death 1 inhibitors in hepatocellular carcinoma
inferred← citeshttps://doi.org/10.1007/s11596-022-2643-zopenalex-snapshot
Hypomethylation of Thyroid Peroxidase as a Biomarker for Hepatocellular Carcinoma with Tumor Thrombosis
inferred← citeshttps://doi.org/10.1007/s13237-017-0193-8openalex-snapshot
Contribution of nuclear events in generation and maintenance of cancer stem cells: revisiting chemo-resistance
inferred← citeshttps://doi.org/10.1007/s40778-017-0070-zopenalex-snapshot
Steroid Hormones and the Physiological Regulation of Tissue-Resident Stem Cells: Lessons from the Drosophila Ovary
inferred← citeshttps://doi.org/10.1016/j.prp.2018.09.005openalex-snapshot
Evaluation of NCAM and c-Kit as hepatic progenitor cell markers for intrahepatic cholangiocarcinomas
inferred← citeshttps://doi.org/10.1038/s41598-018-22915-4openalex-snapshot
Evaluation of the selective toxic effect of the charge switchable diethyldithiocarbamate-loaded nanoparticles between hepatic normal and cancerous cells
inferred← citeshttps://doi.org/10.1097/md.0000000000019492openalex-snapshot
Can hypothyroidism be a protective factor for hepatocellular carcinoma in cirrhosis?
inferred← citeshttps://doi.org/10.1111/apt.70427openalex-snapshot
Meta‐Analysis: Immune‐Related Adverse Events Are Associated With Improved Effectiveness of Immune Checkpoint Inhibitors in Hepatocellular Carcinoma
inferred← citeshttps://doi.org/10.1177/0300060519885302openalex-snapshot
Decelerated tumor growth due to hypothyroidism with prolongation of survival in a patient with lung adenocarcinoma: a case report
inferred← citeshttps://doi.org/10.1186/s13287-026-05014-4openalex-snapshot
The metabolic profiles of cancer stem cells
inferred← citeshttps://doi.org/10.1530/erc-17-0192openalex-snapshot
Role of thyroid hormones in the neoplastic process: an overview
inferred← citeshttps://doi.org/10.1530/erc-18-0097openalex-snapshot
Current concepts and challenges to unravel the role of iodothyronine deiodinases in human neoplasias
inferred← citeshttps://doi.org/10.1530/erc-18-0176openalex-snapshot
Thyroid hormone negatively regulates tumorigenesis through suppression of BC200
inferred← citeshttps://doi.org/10.17650/2313-805x-2018-5-4-78-85openalex-snapshot
Small GTPase Rab3B: biological properties and possible role in carcinogenesis
inferred← citeshttps://doi.org/10.3389/fendo.2019.00059openalex-snapshot
Thyroid Hormones and Cancer: A Comprehensive Review of Preclinical and Clinical Studies
inferred← citeshttps://doi.org/10.3389/fmed.2020.00174openalex-snapshot
Thyroid Hormone in Hepatocellular Carcinoma: Cancer Risk, Growth Regulation, and Anticancer Drug Resistance
inferred← citeshttps://doi.org/10.3389/fphar.2020.00198openalex-snapshot
Cancer Stem Cells: A Potential Breakthrough in HCC-Targeted Therapy
inferred← citeshttps://doi.org/10.3390/cancers13112693openalex-snapshot
Involvement of Thyroid Hormones in Brain Development and Cancer
inferred← citeshttps://doi.org/10.3390/ijms20204986openalex-snapshot
Molecular Functions of Thyroid Hormone Signaling in Regulation of Cancer Progression and Anti-Apoptosis
inferred← citeshttps://doi.org/10.3892/or.2022.8458openalex-snapshot
Triiodothyronine lowers the potential of colorectal cancer stem cells in vitro
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