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Characterization of primary human hepatocyte spheroids as a model system for drug-induced liver injury, liver function and disease
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
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Recent advances in three‐dimensional multicellular spheroid culture for biomedical research
inferredcites →https://doi.org/10.1002/biot.201000326openalex-snapshot
Modular bioreactor for primary human hepatocyte culture: Medium flow stimulates expression and activity of detoxification genes
inferredcites →https://doi.org/10.1002/hep.23575openalex-snapshot
Bioluminescence imaging allows measuring CD8 T cell function in the liver†
inferredcites →https://doi.org/10.1002/hep.24760openalex-snapshot
Human liver cell spheroids in extended perfusion bioreactor culture for repeated-dose drug testing
inferredcites →https://doi.org/10.1002/hep.26160openalex-snapshot
Oxidative stress plays a major role in chlorpromazine-induced cholestasis in human HepaRG cells
inferredcites →https://doi.org/10.1002/hep.26414openalex-snapshot
Proteome-Wide Analyses of Human Hepatocytes During Differentiation and Dedifferentiation
inferredcites →https://doi.org/10.1002/term.418openalex-snapshot
In-depth physiological characterization of primary human hepatocytes in a 3D hollow-fiber bioreactor
inferredcites →https://doi.org/10.1007/s00204-012-0968-2openalex-snapshot
Multi-cell type human liver microtissues for hepatotoxicity testing
inferredcites →https://doi.org/10.1007/s00204-013-1078-5openalex-snapshot
Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME
inferredcites →https://doi.org/10.1007/s00441-005-0148-2openalex-snapshot
Dynamic analysis of hepatoma spheroid formation: roles of E-cadherin and β1-integrin
inferredcites →https://doi.org/10.1016/b978-0-408-71015-2.50010-9openalex-snapshot
INFLUENCE OF NUTRITIONAL FACTORS ON HATCHABILITY
inferredcites →https://doi.org/10.1016/j.bcp.2014.01.020openalex-snapshot
Molecular mechanisms underlying the effects of cyclosporin A and sirolimus on glucose and lipid metabolism in liver, skeletal muscle and adipose tissue in an in vivo rat model
inferredcites →https://doi.org/10.1016/j.biomaterials.2009.01.053openalex-snapshot
The effect of nanofibrous galactosylated chitosan scaffolds on the formation of rat primary hepatocyte aggregates and the maintenance of liver function
inferredcites →https://doi.org/10.1016/j.jprot.2014.05.007openalex-snapshot
Identification and quantification of the basal and inducible Nrf2-dependent proteomes in mouse liver: Biochemical, pharmacological and toxicological implications
inferredcites →https://doi.org/10.1016/j.tips.2010.11.008openalex-snapshot
Pharmacogenomic biomarkers: new tools in current and future drug therapy
inferredcites →https://doi.org/10.1016/s0006-2952(97)00204-9openalex-snapshot
Drug metabolism in hepatocyte sandwich cultures of rats and humans
inferredcites →https://doi.org/10.1016/s0008-6363(02)00846-5openalex-snapshot
Relationships between preclinical cardiac electrophysiology, clinical QT interval prolongation and torsade de pointes for a broad range of drugs: evidence for a provisional safety margin in drug development
inferredcites →https://doi.org/10.1016/s0076-6879(96)72044-xopenalex-snapshot
[42] Use of human hepatocytes to study P450 gene induction
inferredcites →https://doi.org/10.1016/s0168-8278(03)00077-1openalex-snapshot
Gene expression profile in the regenerating rat liver after partial hepatectomy
inferredcites →https://doi.org/10.1016/s0928-0987(01)00135-xopenalex-snapshot
Human hepatocyte culture systems for the in vitro evaluation of cytochrome P450 expression and regulation
inferredcites →https://doi.org/10.1038/clpt.1985.22openalex-snapshot
Absolute bioavailability of amiodarone in normal subjects
inferredcites →https://doi.org/10.1038/nrd3801openalex-snapshot
The determination and interpretation of the therapeutic index in drug development
inferredcites →https://doi.org/10.1046/j.1365-2125.1999.00036.xopenalex-snapshot
Metabolism and excretion of tolcapone, a novel inhibitor of catechol‐O‐methyltransferase
inferredcites →https://doi.org/10.1056/nejm199510263331702openalex-snapshot
Hepatic Failure and Lactic Acidosis Due to Fialuridine (FIAU), an Investigational Nucleoside Analogue for Chronic Hepatitis B
inferredcites →https://doi.org/10.1056/nejmoa0907929openalex-snapshot
Pioglitazone, Vitamin E, or Placebo for Nonalcoholic Steatohepatitis
inferredcites →https://doi.org/10.1073/pnas.1413481111openalex-snapshot
Prediction of interindividual differences in hepatic functions and drug sensitivity by using human iPS-derived hepatocytes
inferredcites →https://doi.org/10.1080/00498250210128675openalex-snapshot
Cytochrome P450 expression in human hepatocytes and hepatoma cell lines: molecular mechanisms that determine lower expression in cultured cells
inferredcites →https://doi.org/10.1080/03602530601093489openalex-snapshot
Primary Hepatocytes: Current Understanding of the Regulation of Metabolic Enzymes and Transporter Proteins, and Pharmaceutical Practice for the Use of Hepatocytes in Metabolism, Enzyme Induction, Transporter, Clearance, and Hepatotoxicity Studies
inferredcites →https://doi.org/10.1083/jcb.101.3.914openalex-snapshot
Spheroidal aggregate culture of rat liver cells: histotypic reorganization, biomatrix deposition, and maintenance of functional activities.
inferredcites →https://doi.org/10.1089/adt.2011.0371openalex-snapshot
Rat Primary Hepatocytes Show Enhanced Performance and Sensitivity to Acetaminophen During Three-Dimensional Culture on a Polystyrene Scaffold Designed for Routine Use
inferredcites →https://doi.org/10.1093/jn/134.3.489openalex-snapshot
Glutathione Metabolism and Its Implications for Health
inferredcites →https://doi.org/10.1093/toxsci/kfm218openalex-snapshot
Lipopolysaccharide and Trovafloxacin Coexposure in Mice Causes Idiosyncrasy-Like Liver Injury Dependent on Tumor Necrosis Factor-Alpha
inferredcites →https://doi.org/10.1093/toxsci/kfv136openalex-snapshot
Comparative Proteomic Characterization of 4 Human Liver-Derived Single Cell Culture Models Reveals Significant Variation in the Capacity for Drug Disposition, Bioactivation, and Detoxication
inferredcites →https://doi.org/10.1097/00007890-200607152-01711openalex-snapshot
URINARY ??2 - MICROGLOBULIN IS A SENSITIVE AND SPECIFIC MARKER FOR ACUTE RENAL ALLOGRAFT REJECTION.
inferredcites →https://doi.org/10.1124/mol.112.078386openalex-snapshot
Human CYP2C8 Is Post-Transcriptionally Regulated by MicroRNAs 103 and 107 in Human Liver
inferredcites →https://doi.org/10.1128/aac.38.9.2134openalex-snapshot
Sensitive and specific radioimmunoassay for fialuridine: initial assessment of pharmacokinetics after single oral doses to healthy volunteers
inferredcites →https://doi.org/10.1146/annurev.med.56.082103.104724openalex-snapshot
Pharmacogenomics and Individualized Drug Therapy
inferredcites →https://doi.org/10.1146/annurev.nu.16.070196.001143openalex-snapshot
Zonation of Parenchymal and Nonparenchymal Metabolism in Liver
inferredcites →https://doi.org/10.1177/2211068214566939openalex-snapshot
Microengineered Liver Tissues for Drug Testing
inferredcites →https://doi.org/10.1371/journal.pmed.1001628openalex-snapshot
Fialuridine Induces Acute Liver Failure in Chimeric TK-NOG Mice: A Model for Detecting Hepatic Drug Toxicity Prior to Human Testing
inferredcites →https://doi.org/10.1517/17425255.2014.967680openalex-snapshot
Competency of different cell models to predict human hepatotoxic drugs
inferredcites →https://doi.org/10.2133/dmpk.dmpk-13-rg-105openalex-snapshot
Evaluation of Human Hepatocytes Cultured by Three-dimensional Spheroid Systems for Drug Metabolism
inferredcites →https://doi.org/10.2165/00002018-200730040-00001openalex-snapshot
Drug-Induced Liver Injury
inferredcites →https://doi.org/10.2174/138920006778017759openalex-snapshot
Molecular Mechanisms Underlying the Dedifferentiation Process of Isolated Hepatocytes and Their Cultures
inferredcites →https://doi.org/10.3390/ijms11114697openalex-snapshot
Comparison of TNFα to Lipopolysaccharide as an Inflammagen to Characterize the Idiosyncratic Hepatotoxicity Potential of Drugs: Trovafloxacin as an Example
inferredcites →https://doi.org/10.5414/cp201806openalex-snapshot
Relative bioavailability of a newly developed pediatric formulation of bosentan vs. the adult formulation
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
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Unmasking metabolic disruptors: The NEMESIS project's quest for Novel Biomarkers, Evidence on Adverse Effects, and Efficient Methodologies
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Peptide Hydrogels for 3d Hepatocyte Encapsulation and Function
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Are the BPA Analogues a Plausible Alternative to BPA? Alternative 3D in Vitro Neuron Model is Compared with the Classical 2D Model to Assess Cytotoxic and Genotoxic Effects
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Multi Organ Model Assessment of Neurotoxicity Following Exposure of Liver Spheroids to Drugs
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Long‐term maintenance of functional primary human hepatocytes using small molecules
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Mechanisms of Drug‐induced Liver Injury
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Evaluating Mitotoxicity as Either a Single or Multi‐Mechanistic Insult in the Context of Hepatotoxicity
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Excretion of Drugs and Their Metabolites into the Bile
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Experimental Models for Drug Repurposing in Viral Hepatitis
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Comparative Study between the 3D‐Liver Spheroid Models Developed from HepG2 and Immortalized Hepatocyte‐Like Cells with Primary Hepatic Stellate Coculture for Drug Metabolism Analysis and Anticancer Drug Screening
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A 3D Cell Culture Model Identifies Wnt/β‐Catenin Mediated Inhibition of p53 as a Critical Step during Human Hepatocyte Regeneration
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Consequences of Amyloid‐β Deficiency for the Liver
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Increased hepatic acylcarnitines after oral administration of amiodarone in rats
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Circadian Control of Transcriptional and Metabolic Rhythms in Primary Hepatocytes
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Human Hepatic Spheroid Coculture Model for the Assessment of Drug-Induced Liver Injury
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Engineered Human Liver Cocultures for Investigating Drug-Induced Liver Injury
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Status and Future of 3D Cell Culture in Toxicity Testing
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High Content Screening for Prediction of Human Drug-Induced Liver Injury
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Quantitative Structure–Activity Relationship Models for Predicting Risk of Drug-Induced Liver Injury in Humans
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Ex Vivo Model in Cholestasis Research
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Evaluating the Effect of Drug Compounds on Cardiac Spheroids Using the Cardiac Cell Outgrowth Assay
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Scaffold-Free Biofabrication of Liver
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Methodological Considerations for Setting Up Human-Relevant In Vitro Nanotoxicology Experiments—A Practical Guide
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Organoid Models of Development and Disease Towards Therapy
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Current Research Method in Transporter Study
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Evaluation of a human 3D multicellular hepatic spheroid model as a platform for studying hepatic transporters
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Adjudin improves beta cell maturation, hepatic glucose uptake and glucose homeostasis
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Evidence-based selection of training compounds for use in the mechanism-based integrated prediction of drug-induced liver injury in man
inferred← citeshttps://doi.org/10.1007/s00204-016-1865-xopenalex-snapshot
Maintenance of drug metabolism and transport functions in human precision-cut liver slices during prolonged incubation for 5 days
inferred← citeshttps://doi.org/10.1007/s00204-017-1930-0openalex-snapshot
Evaluation of transcriptomic signature as a valuable tool to study drug-induced cholestasis in primary human hepatocytes
inferred← citeshttps://doi.org/10.1007/s00204-017-2002-1openalex-snapshot
Utility of spherical human liver microtissues for prediction of clinical drug-induced liver injury
inferred← citeshttps://doi.org/10.1007/s00204-018-2152-9openalex-snapshot
Innovative organotypic in vitro models for safety assessment: aligning with regulatory requirements and understanding models of the heart, skin, and liver as paradigms
inferred← citeshttps://doi.org/10.1007/s00204-018-2201-4openalex-snapshot
In vitro prediction of drug-induced cholestatic liver injury: a challenge for the toxicologist
inferred← citeshttps://doi.org/10.1007/s00204-018-2354-1openalex-snapshot
Characterisation of the NRF2 transcriptional network and its response to chemical insult in primary human hepatocytes: implications for prediction of drug-induced liver injury
inferred← citeshttps://doi.org/10.1007/s00204-018-2375-9openalex-snapshot
A simple approach for restoration of differentiation and function in cryopreserved human hepatocytes
inferred← citeshttps://doi.org/10.1007/s00204-019-02427-4openalex-snapshot
Integrated in vitro models for hepatic safety and metabolism: evaluation of a human Liver-Chip and liver spheroid
inferred← citeshttps://doi.org/10.1007/s00204-019-02437-2openalex-snapshot
Mechanisms and in vitro models of drug-induced cholestasis
inferred← citeshttps://doi.org/10.1007/s00204-019-02552-0openalex-snapshot
High-throughput confocal imaging of differentiated 3D liver-like spheroid cellular stress response reporters for identification of drug-induced liver injury liability
inferred← citeshttps://doi.org/10.1007/s00204-019-02585-5openalex-snapshot
The application of omics-based human liver platforms for investigating the mechanism of drug-induced hepatotoxicity in vitro
inferred← citeshttps://doi.org/10.1007/s00204-020-02682-wopenalex-snapshot
Functionality of primary hepatic non-parenchymal cells in a 3D spheroid model and contribution to acetaminophen hepatotoxicity
inferred← citeshttps://doi.org/10.1007/s00204-020-02763-wopenalex-snapshot
The evolution of strategies to minimise the risk of human drug-induced liver injury (DILI) in drug discovery and development
inferred← citeshttps://doi.org/10.1007/s00204-020-02940-xopenalex-snapshot
Hepatotoxicity induced by nanomaterials: mechanisms and in vitro models
inferred← citeshttps://doi.org/10.1007/s00204-021-03050-yopenalex-snapshot
Assessment of long-term functional maintenance of primary human hepatocytes to predict drug-induced hepatoxicity in vitro
inferred← citeshttps://doi.org/10.1007/s00204-021-03177-yopenalex-snapshot
Expression dynamics of pregnane X receptor-controlled genes in 3D primary human hepatocyte spheroids
inferred← citeshttps://doi.org/10.1007/s00204-021-03178-xopenalex-snapshot
DMSO-free highly differentiated HepaRG spheroids for chronic toxicity, liver functions and genotoxicity studies
inferred← citeshttps://doi.org/10.1007/s00204-021-03182-1openalex-snapshot
Investigating the in vitro steatotic mixture effects of similarly and dissimilarly acting test compounds using an adverse outcome pathway-based approach
inferred← citeshttps://doi.org/10.1007/s00204-022-03234-0openalex-snapshot
Implementing organ-on-chip in a next-generation risk assessment of chemicals: a review
inferred← citeshttps://doi.org/10.1007/s00204-025-04263-1openalex-snapshot
Exploring the potential of liver microphysiological systems of varied configurations to model cholestatic chemical effects
inferred← citeshttps://doi.org/10.1007/s00204-025-04296-6openalex-snapshot
Single-cell transcriptomics of acetaminophen-induced responses in human 2D and 3D liver microtissues
inferred← citeshttps://doi.org/10.1007/s00204-026-04431-xopenalex-snapshot
Free Fatty acid-induced disruption of hepatic vitamin D metabolism impairs bone homeostasis in an in vitro 3D human liver–bone model
inferred← citeshttps://doi.org/10.1007/s00204-026-04502-zopenalex-snapshot
Cell line identity rather than medium composition determines transcriptomic profiles of HepaRG and HuH7 cells cultured in chemically defined or serum-based media: comparison with primary human hepatocytes
inferred← citeshttps://doi.org/10.1007/s10529-018-2528-1openalex-snapshot
Hepatic esterase activity is increased in hepatocyte-like cells derived from human embryonic stem cells using a 3D culture system
inferred← citeshttps://doi.org/10.1007/s10646-021-02459-6openalex-snapshot
Development of 3D cultures of zebrafish liver and embryo cell lines: a comparison of different spheroid formation methods
inferred← citeshttps://doi.org/10.1007/s11033-025-11337-xopenalex-snapshot
Transforming growth factor-β1 triggers the proliferation of human cholangiocyte spheroids via interleukin-6-mediated STAT3 signaling
inferred← citeshttps://doi.org/10.1007/s11626-020-00451-8openalex-snapshot
Comparative analysis of bilirubin glucuronidation activity in 2D- and 3D-cultured human hepatocellular carcinoma HepG2 cells
inferred← citeshttps://doi.org/10.1007/s11626-022-00711-9openalex-snapshot
Comparative analysis of bilirubin glucuronidation activity in canine and human primary hepatocytes using a 3D culture system
inferred← citeshttps://doi.org/10.1007/s12072-017-9838-6openalex-snapshot
Translating scientific discovery: the need for preclinical models of nonalcoholic steatohepatitis
inferred← citeshttps://doi.org/10.1007/s13105-025-01130-6openalex-snapshot
Preclinical research in obesity-associated metabolic diseases using in vitro, multicellular, and non-mammalian models
inferred← citeshttps://doi.org/10.1007/s13206-021-00007-2openalex-snapshot
Assembly and Disassembly of the Micropatterned Collagen Sheets Containing Cells for Location-Based Cellular Function Analysis
inferred← citeshttps://doi.org/10.1007/s13318-018-0502-xopenalex-snapshot
Evaluation of Drug Biliary Excretion Using Sandwich-Cultured Human Hepatocytes
inferred← citeshttps://doi.org/10.1007/s13770-017-0107-5openalex-snapshot
A Non-woven Path: Electrospun Poly(lactic acid) Scaffolds for Kidney Tissue Engineering
inferred← citeshttps://doi.org/10.1007/s13770-020-00245-9openalex-snapshot
Gaining New Biological and Therapeutic Applications into the Liver with 3D In Vitro Liver Models
inferred← citeshttps://doi.org/10.1007/s13770-020-00272-6openalex-snapshot
Generation of Scalable Hepatic Micro-Tissues as a Platform for Toxicological Studies
inferred← citeshttps://doi.org/10.1007/s13770-025-00736-7openalex-snapshot
Enhancing Long-Term Survival and Self-Renewal of Primary Hepatocytes via Rapid Spheroid Formation Using Rocker System through Co-Culturing with HUVEC Over-Expressing RSPO1
inferred← citeshttps://doi.org/10.1007/s40259-017-0258-xopenalex-snapshot
Applications of Bioengineered 3D Tissue and Tumor Organoids in Drug Development and Precision Medicine: Current and Future
inferred← citeshttps://doi.org/10.1007/s40883-018-0046-2openalex-snapshot
3D Co-Culture with Vascular Cells Supports Long-Term Hepatocyte Phenotype and Function In Vitro
inferred← citeshttps://doi.org/10.1007/s41664-026-00496-wopenalex-snapshot
Chiral Separation of Tacrine-Based Metabolites: A Step Towards a Safe, Highly Active Drug
inferred← citeshttps://doi.org/10.1007/s42242-021-00137-4openalex-snapshot
Biofabrication of size-controlled liver microtissues incorporated with ECM-derived microparticles to prolong hepatocyte function
inferred← citeshttps://doi.org/10.1007/s42242-021-00142-7openalex-snapshot
Recent advances in the development of in vitro liver models for hepatotoxicity testing
inferred← citeshttps://doi.org/10.1016/b978-0-08-102906-0.00020-9openalex-snapshot
In vitro disease and organ model
inferred← citeshttps://doi.org/10.1016/b978-0-12-801238-3.64267-8openalex-snapshot
Leading-Edge Approaches for In Vitro Hepatotoxicity Evaluation
inferred← citeshttps://doi.org/10.1016/b978-0-12-803581-8.10163-8openalex-snapshot
6.28 Liver Tissue Engineering ☆
inferred← citeshttps://doi.org/10.1016/b978-0-12-812301-0.00007-4openalex-snapshot
Generation of Liver Organoids and Their Potential Applications
inferred← citeshttps://doi.org/10.1016/b978-0-12-813671-3.00005-0openalex-snapshot
Application of complex in vitro models (CIVMs) in drug discovery for safety testing and disease modeling
inferred← citeshttps://doi.org/10.1016/b978-0-12-813671-3.00006-2openalex-snapshot
Hepatic microphysiological systems: Current and future applications in drug discovery and development
inferred← citeshttps://doi.org/10.1016/b978-0-12-813697-3.00029-9openalex-snapshot
The Development and Application of Key Technologies and Tools
inferred← citeshttps://doi.org/10.1016/b978-0-12-817202-5.00002-4openalex-snapshot
Cell sources and methods for producing organotypic in vitro human tissue models
inferred← citeshttps://doi.org/10.1016/b978-0-12-817202-5.00011-5openalex-snapshot
Computational pharmacokinetic modeling of organ-on-chip devices and microphysiological systems
inferred← citeshttps://doi.org/10.1016/b978-0-12-818422-6.00041-1openalex-snapshot
Hepatic tissue engineering
inferred← citeshttps://doi.org/10.1016/b978-0-12-820301-9.00008-2openalex-snapshot
Emerging trends of three-dimensional printing in biotechnology
inferred← citeshttps://doi.org/10.1016/b978-0-12-823524-9.00012-5openalex-snapshot
Human hepatocyte transplantation
inferred← citeshttps://doi.org/10.1016/b978-0-12-823966-7.00003-7openalex-snapshot
Overcoming the barriers of two-dimensional cell culture systems with three-dimensional cell culture systems: techniques, drug discovery, and biomedical applications
inferred← citeshttps://doi.org/10.1016/b978-0-323-95262-0.00007-3openalex-snapshot
Advanced models to study liver sinusoids
inferred← citeshttps://doi.org/10.1016/b978-0-443-15840-7.00012-9openalex-snapshot
Clinical detoxification of the body from chemical toxicants
inferred← citeshttps://doi.org/10.1016/b978-0-443-29289-7.00020-5openalex-snapshot
Introduction of drug metabolism and overview of disease effect on drug metabolism
inferred← citeshttps://doi.org/10.1016/b978-0-443-30151-3.00007-3openalex-snapshot
Liver Tissue Engineering
inferred← citeshttps://doi.org/10.1016/b978-0-443-33455-9.00003-1openalex-snapshot
Tissue engineering: methods for scaffolds to extracellular matrix and scaffold to cell interaction
inferred← citeshttps://doi.org/10.1016/bs.apha.2018.08.001openalex-snapshot
Primary hepatocytes and their cultures for the testing of drug-induced liver injury
inferred← citeshttps://doi.org/10.1016/bs.apha.2022.04.004openalex-snapshot
Cytochrome P450 polymorphism: From evolution to clinical use
inferred← citeshttps://doi.org/10.1016/bs.asn.2021.10.002openalex-snapshot
Recapitulating the liver niche in vitro
inferred← citeshttps://doi.org/10.1016/j.actbio.2017.09.041openalex-snapshot
Elasticity-based development of functionally enhanced multicellular 3D liver encapsulated in hybrid hydrogel
inferred← citeshttps://doi.org/10.1016/j.actbio.2019.02.005openalex-snapshot
Endoplasmic reticulum-targeted phototherapy using one-step synthesized trace metal-doped carbon-dominated nanoparticles: Laser-triggered nucleolar delivery and increased tumor accumulation
inferred← citeshttps://doi.org/10.1016/j.actbio.2021.11.027openalex-snapshot
Constructing Vascularized Hepatic Tissue by Cell Assembled Viscous Tissue Sedimentation Method and Its Application for Vascular Toxicity Assessment
inferred← citeshttps://doi.org/10.1016/j.actbio.2023.09.022openalex-snapshot
3D microperfusion of mesoscale human microphysiological liver models improves functionality and recapitulates hepatic zonation
inferred← citeshttps://doi.org/10.1016/j.addr.2017.07.004openalex-snapshot
3D in vitro models of liver fibrosis
inferred← citeshttps://doi.org/10.1016/j.addr.2020.09.012openalex-snapshot
Engineered tissues and strategies to overcome challenges in drug development
inferred← citeshttps://doi.org/10.1016/j.apmt.2026.103310openalex-snapshot
Bridging biology and technology: In vitro 3D liver models for drug metabolism and pharmacokinetic studies
inferred← citeshttps://doi.org/10.1016/j.apsb.2016.12.006openalex-snapshot
Regulation of drug metabolism and toxicity by multiple factors of genetics, epigenetics, lncRNAs, gut microbiota, and diseases: a meeting report of the 21st International Symposium on Microsomes and Drug Oxidations (MDO)
inferred← citeshttps://doi.org/10.1016/j.apsb.2021.11.013openalex-snapshot
Preclinical models of idiosyncratic drug-induced liver injury (iDILI): Moving towards prediction
inferred← citeshttps://doi.org/10.1016/j.aquatox.2022.106105openalex-snapshot
Transcriptomic and physiological analysis of endocrine disrupting chemicals Impacts on 3D Zebrafish liver cell culture system
inferred← citeshttps://doi.org/10.1016/j.atherosclerosis.2024.117544openalex-snapshot
3D culture models to study pathophysiology of steatotic liver disease
inferred← citeshttps://doi.org/10.1016/j.bbadis.2025.167888openalex-snapshot
Engineering a three-dimensional liver steatosis model
inferred← citeshttps://doi.org/10.1016/j.bbcan.2020.188350openalex-snapshot
Application of organoids in translational research of human diseases with a particular focus on gastrointestinal cancers
inferred← citeshttps://doi.org/10.1016/j.bbiosy.2022.100054openalex-snapshot
Setup of human liver-chips integrating 3D models, microwells and a standardized microfluidic platform as proof-of-concept study to support drug evaluation
inferred← citeshttps://doi.org/10.1016/j.bbiosy.2022.100063openalex-snapshot
Design considerations of benchtop fluid flow bioreactors for bio-engineered tissue equivalents in vitro
inferred← citeshttps://doi.org/10.1016/j.bbrep.2017.04.004openalex-snapshot
Scaffold-free 3D bio-printed human liver tissue stably maintains metabolic functions useful for drug discovery
inferred← citeshttps://doi.org/10.1016/j.bbrep.2023.101503openalex-snapshot
Galactosylation of rat natural scaffold for MSC differentiation into hepatocyte-like cells: A comparative analysis of 2D vs. 3D cell culture techniques
inferred← citeshttps://doi.org/10.1016/j.bcp.2018.06.026openalex-snapshot
Critical differences in drug metabolic properties of human hepatic cellular models, including primary human hepatocytes, stem cell derived hepatocytes, and hepatoma cell lines
inferred← citeshttps://doi.org/10.1016/j.bcp.2020.114173openalex-snapshot
From fatty hepatocytes to impaired bile flow: Matching model systems for liver biology and disease
inferred← citeshttps://doi.org/10.1016/j.bcp.2023.115755openalex-snapshot
Comparative analysis of YAP/TEAD inhibitors in 2D and 3D cultures of primary human hepatocytes reveals a novel non-canonical mechanism of CYP induction
inferred← citeshttps://doi.org/10.1016/j.bcp.2024.116500openalex-snapshot
Rifampicin and its derivatives: stability, disposition, and affinity towards pregnane X receptor employing 2D and 3D primary human hepatocytes
inferred← citeshttps://doi.org/10.1016/j.bcp.2026.118439openalex-snapshot
Multilayered clearance concept: a membrane-resolved flux framework for drug metabolism
inferred← citeshttps://doi.org/10.1016/j.bioadv.2022.212973openalex-snapshot
Interplay between crosslinking and ice nucleation controls the porous structure of freeze-dried hydrogel scaffolds
inferred← citeshttps://doi.org/10.1016/j.bioadv.2023.213499openalex-snapshot
3D bioprinted liver tissue and disease models: Current advances and future perspectives
inferred← citeshttps://doi.org/10.1016/j.bioadv.2026.215250openalex-snapshot
Highly functional 3D fibrin-embedded hepatocyte tissues with long-term functional stability constructed via the CAViTs method
inferred← citeshttps://doi.org/10.1016/j.biomaterials.2018.07.043openalex-snapshot
Human iPS derived progenitors bioengineered into liver organoids using an inverted colloidal crystal poly (ethylene glycol) scaffold
inferred← citeshttps://doi.org/10.1016/j.biomaterials.2018.11.016openalex-snapshot
Generation of mature kupffer cells from human induced pluripotent stem cells
inferred← citeshttps://doi.org/10.1016/j.biomaterials.2019.01.046openalex-snapshot
Cleavable cellulosic sponge for functional hepatic cell culture and retrieval
inferred← citeshttps://doi.org/10.1016/j.biomaterials.2019.05.032openalex-snapshot
Hepatic spheroids used as an in vitro model to study malaria relapse
inferred← citeshttps://doi.org/10.1016/j.biomaterials.2020.120529openalex-snapshot
Generation of uniform liver spheroids from human pluripotent stem cells for imaging-based drug toxicity analysis
inferred← citeshttps://doi.org/10.1016/j.biomaterials.2022.121881openalex-snapshot
Strategies for 3D bioprinting of spheroids: A comprehensive review
inferred← citeshttps://doi.org/10.1016/j.biomaterials.2023.122408openalex-snapshot
A comprehensive review on 3D tissue models: Biofabrication technologies and preclinical applications
inferred← citeshttps://doi.org/10.1016/j.biomaterials.2024.122627openalex-snapshot
Microfluidic human physiomimetic liver model as a screening platform for drug induced liver injury
inferred← citeshttps://doi.org/10.1016/j.biomaterials.2025.123256openalex-snapshot
Bioprinted high cell density liver model with improved hepatic metabolic functions
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