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Glucose level determines excitatory or inhibitory effects of adiponectin on arcuate POMC neuron activity and feeding

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1006/bbrc.1996.0587openalex-snapshot
cDNA Cloning and Expression of a Novel Adipose Specific Collagen-like Factor, apM1 (AdiposeMost Abundant Gene Transcript 1)
inferredcites →https://doi.org/10.1016/j.bbrc.2007.03.004openalex-snapshot
Selective purification and characterization of adiponectin multimer species from human plasma
inferredcites →https://doi.org/10.1016/j.beem.2013.09.003openalex-snapshot
Adiponectin receptors: A review of their structure, function and how they work
inferredcites →https://doi.org/10.1016/j.brainres.2008.12.012openalex-snapshot
Adiponectin acts in the nucleus of the solitary tract to decrease blood pressure by modulating the excitability of neuropeptide Y neurons
inferredcites →https://doi.org/10.1016/j.cmet.2004.12.003openalex-snapshot
AMP-activated protein kinase: Ancient energy gauge provides clues to modern understanding of metabolism
inferredcites →https://doi.org/10.1016/j.cmet.2007.06.003openalex-snapshot
Adiponectin Stimulates AMP-Activated Protein Kinase in the Hypothalamus and Increases Food Intake
inferredcites →https://doi.org/10.1016/j.cmet.2008.01.006openalex-snapshot
PDK1 Deficiency in POMC-Expressing Cells Reveals FOXO1-Dependent and -Independent Pathways in Control of Energy Homeostasis and Stress Response
inferredcites →https://doi.org/10.1016/j.cmet.2009.09.008openalex-snapshot
Dominant Role of the p110β Isoform of PI3K over p110α in Energy Homeostasis Regulation by POMC and AgRP Neurons
inferredcites →https://doi.org/10.1016/j.cmet.2012.05.010openalex-snapshot
p70S6 Kinase Phosphorylates AMPK on Serine 491 to Mediate Leptin's Effect on Food Intake
inferredcites →https://doi.org/10.1016/j.cmet.2013.04.009openalex-snapshot
Adiponectin Regulates Bone Mass via Opposite Central and Peripheral Mechanisms through FoxO1
inferredcites →https://doi.org/10.1016/j.cmet.2014.03.004openalex-snapshot
Insulin Excites Anorexigenic Proopiomelanocortin Neurons via Activation of Canonical Transient Receptor Potential Channels
inferredcites →https://doi.org/10.1016/j.febslet.2007.11.063openalex-snapshot
Neuronal control of energy homeostasis
inferredcites →https://doi.org/10.1016/j.febslet.2008.03.037openalex-snapshot
AdipoR1 mediates the anorexigenic and insulin/leptin‐like actions of adiponectin in the hypothalamus
inferredcites →https://doi.org/10.1016/j.molcel.2004.11.050openalex-snapshot
Osmotin Is a Homolog of Mammalian Adiponectin and Controls Apoptosis in Yeast through a Homolog of Mammalian Adiponectin Receptor
inferredcites →https://doi.org/10.1016/j.molcel.2008.03.003openalex-snapshot
AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint
inferredcites →https://doi.org/10.1016/j.npep.2015.08.008openalex-snapshot
Fasted/fed states regulate postsynaptic hub protein DYNLL2 and glutamatergic transmission in oxytocin neurons in the hypothalamic paraventricular nucleus
inferredcites →https://doi.org/10.1016/s0092-8674(03)00929-2openalex-snapshot
TSC2 Mediates Cellular Energy Response to Control Cell Growth and Survival
inferredcites →https://doi.org/10.1016/s0304-3940(99)00185-8openalex-snapshot
Glucose-sensitive neurons in the rat arcuate nucleus contain neuropeptide Y
inferredcites →https://doi.org/10.1038/35007534openalex-snapshot
Central nervous system control of food intake
inferredcites →https://doi.org/10.1038/35078085openalex-snapshot
Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus
inferredcites →https://doi.org/10.1038/ijo.2008.233openalex-snapshot
Physiological and pathophysiological roles of adiponectin and adiponectin receptors in the integrated regulation of metabolic and cardiovascular diseases
inferredcites →https://doi.org/10.1038/nature02440openalex-snapshot
AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus
inferredcites →https://doi.org/10.1038/nature08991openalex-snapshot
Adiponectin and AdipoR1 regulate PGC-1α and mitochondria by Ca2+ and AMPK/SIRT1
inferredcites →https://doi.org/10.1038/ncomms7618openalex-snapshot
Interplay between glucose and leptin signalling determines the strength of GABAergic synapses at POMC neurons
inferredcites →https://doi.org/10.1038/nm.2026openalex-snapshot
The obesity susceptibility gene Cpe links FoxO1 signaling in hypothalamic pro-opiomelanocortin neurons with regulation of food intake
inferredcites →https://doi.org/10.1038/nm1029openalex-snapshot
Adiponectin acts in the brain to decrease body weight
inferredcites →https://doi.org/10.1038/nm1557openalex-snapshot
Targeted disruption of AdipoR1 and AdipoR2 causes abrogation of adiponectin binding and metabolic actions
inferredcites →https://doi.org/10.1055/s-2007-978586openalex-snapshot
An Adipocyte-Derived Plasma Protein, Adiponectin, Adheres to Injured Vascular Walls
inferredcites →https://doi.org/10.1074/jbc.m202045200openalex-snapshot
Multiple Regulatory Roles of a Novel Saccharomyces cerevisiae Protein, Encoded by YOL002c, in Lipid and Phosphate Metabolism
inferredcites →https://doi.org/10.1074/jbc.m506850200openalex-snapshot
Insulin Antagonizes Ischemia-induced Thr172 Phosphorylation of AMP-activated Protein Kinase α-Subunits in Heart via Hierarchical Phosphorylation of Ser485/491
inferredcites →https://doi.org/10.1074/jbc.m610101200openalex-snapshot
Energy Depletion Inhibits Phosphatidylinositol 3-Kinase/Akt Signaling and Induces Apoptosis via AMP-activated Protein Kinase-dependent Phosphorylation of IRS-1 at Ser-794
inferredcites →https://doi.org/10.1111/j.1460-9568.2004.03255.xopenalex-snapshot
Orexins (hypocretins) directly interact with neuropeptide Y, POMC and glucose‐responsive neurons to regulate Ca2+ signaling in a reciprocal manner to leptin: orexigenic neuronal pathways in the mediobasal hypothalamus
inferredcites →https://doi.org/10.1113/jphysiol.2007.144519openalex-snapshot
Adiponectin selectively inhibits oxytocin neurons of the paraventricular nucleus of the hypothalamus
inferredcites →https://doi.org/10.1146/annurev.neuro.30.051606.094324openalex-snapshot
Neurobiology of Feeding and Energy Expenditure
inferredcites →https://doi.org/10.1152/ajpendo.00446.2014openalex-snapshot
Arcuate Na+,K+-ATPase senses systemic energy states and regulates feeding behavior through glucose-inhibited neurons
inferredcites →https://doi.org/10.1152/ajpendo.00512.2009openalex-snapshot
PDK-1/FoxO1 pathway in POMC neurons regulatesPomcexpression and food intake
inferredcites →https://doi.org/10.1152/physiol.00050.2013openalex-snapshot
AMPK: Regulating Energy Balance at the Cellular and Whole Body Levels
inferredcites →https://doi.org/10.1172/jci31516openalex-snapshot
AMPK is essential for energy homeostasis regulation and glucose sensing by POMC and AgRP neurons
inferredcites →https://doi.org/10.1172/jci32964openalex-snapshot
Acute effects of leptin require PI3K signaling in hypothalamic proopiomelanocortin neurons in mice
inferredcites →https://doi.org/10.1210/en.2008-1179openalex-snapshot
Adiponectin Depolarizes Parvocellular Paraventricular Nucleus Neurons Controlling Neuroendocrine and Autonomic Function
inferredcites →https://doi.org/10.1210/en.2009-1390openalex-snapshot
Adiponectin Modulates Excitability of Rat Paraventricular Nucleus Neurons by Differential Modulation of Potassium Currents
inferredcites →https://doi.org/10.1210/en.2013-1734openalex-snapshot
Central Adiponectin Acutely Improves Glucose Tolerance in Male Mice
inferredcites →https://doi.org/10.1210/er.2005-0005openalex-snapshot
Adiponectin and Adiponectin Receptors
inferredcites →https://doi.org/10.1523/jneurosci.4816-09.2010openalex-snapshot
Leptin Excites Proopiomelanocortin Neurons via Activation of TRPC Channels
inferredcites →https://doi.org/10.1677/joe-08-0348openalex-snapshot
Adiponectin receptors are expressed in hypothalamus and colocalized with proopiomelanocortin and neuropeptide Y in rodent arcuate neurons
inferredcites →https://doi.org/10.2337/db06-0567openalex-snapshot
Characterization of Glucosensing Neuron Subpopulations in the Arcuate Nucleus
inferredcites →https://doi.org/10.3389/fnsys.2014.00236openalex-snapshot
Hypothalamic glucose sensing: making ends meet

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.4353413openalex-extracted
Adiponectin Derived Peptide, Adp-1, Regulates Food Intake of Siberian Sturgeon (Acipenser Baerii) Through Mediating Hypothalamic and Gastrointestinal Peptides Gene Expression
inferred← citeshttps://doi.org/10.1002/cphy.c160045openalex-snapshot
CNS Targets of Adipokines
inferred← citeshttps://doi.org/10.1002/cphy.c190042openalex-snapshot
Impact of Gut and Metabolic Hormones on Feeding Reward
inferred← citeshttps://doi.org/10.1002/j.2040-4603.2017.tb00781.xopenalex-snapshot
CNS Targets of Adipokines
inferred← citeshttps://doi.org/10.1002/j.2040-4603.2021.tb00153.xopenalex-snapshot
Impact of Gut and Metabolic Hormones on Feeding Reward
inferred← citeshttps://doi.org/10.1007/7854_2018_54openalex-snapshot
Hypothalamic Integration of the Endocrine Signaling Related to Food Intake
inferred← citeshttps://doi.org/10.1007/978-3-319-63260-5_3openalex-snapshot
Neuroendocrinology of Adipose Tissue and Gut–Brain Axis
inferred← citeshttps://doi.org/10.1007/978-981-16-9016-7_10openalex-snapshot
Adipose Tissue as an Endocrine Organ and a Glance on Local Hormones
inferred← citeshttps://doi.org/10.1007/s11154-025-10009-2openalex-snapshot
The hypothalamus as a therapeutic target: Towards novel approaches for managing antipsychotic-induced weight gain
inferred← citeshttps://doi.org/10.1007/s13340-023-00674-6openalex-snapshot
Influence of diet and body weight in treatment-resistant acquired partial lipodystrophy after hematopoietic stem cell transplantation and its potential for metabolic improvement
inferred← citeshttps://doi.org/10.1016/b978-0-12-813814-4.00031-6openalex-snapshot
Hormone Effects on Tumors
inferred← citeshttps://doi.org/10.1016/bs.irn.2019.06.002openalex-snapshot
Potential exerkines for physical exercise-elicited pro-cognitive effects: Insight from clinical and animal research
inferred← citeshttps://doi.org/10.1016/j.appet.2021.105442openalex-snapshot
Gut hormones, adipokines, and pro- and anti-inflammatory cytokines/markers in loss of control eating: A scoping review
inferred← citeshttps://doi.org/10.1016/j.aquaculture.2024.741594openalex-snapshot
Globular adiponectin, acting via AdipoR1, regulates food intake of Siberian sturgeon (Acipenser baerii) in a mTOR dependent manner
inferred← citeshttps://doi.org/10.1016/j.biochi.2022.09.006openalex-snapshot
Do POMC neurons have a sweet tooth for leptin? Special issue: Role of nutrients in nervous control of energy balance
inferred← citeshttps://doi.org/10.1016/j.conb.2017.02.002openalex-snapshot
The C1q complement family of synaptic organizers: not just complementary
inferred← citeshttps://doi.org/10.1016/j.cyto.2018.04.013openalex-snapshot
Acute physical exercise increases the adaptor protein APPL1 in the hypothalamus of obese mice
inferred← citeshttps://doi.org/10.1016/j.cyto.2018.06.012openalex-snapshot
Adiponectin signaling and its role in bone metabolism
inferred← citeshttps://doi.org/10.1016/j.ijbiomac.2022.06.097openalex-snapshot
Molecular cloning, expression and appetite regulation function of adiponectin in Siberian sturgeon (Acipenser baerii)
inferred← citeshttps://doi.org/10.1016/j.molmet.2020.01.021openalex-snapshot
Hypothalamic POMC deficiency increases circulating adiponectin despite obesity
inferred← citeshttps://doi.org/10.1016/j.neuroscience.2019.05.033openalex-snapshot
Insulin Modulates Excitatory Synaptic Transmission and Synaptic Plasticity in the Mouse Hippocampus
inferred← citeshttps://doi.org/10.1016/j.npep.2017.03.003openalex-snapshot
Adiponectin at physiological level glucose-independently enhances inhibitory postsynaptic current onto NPY neurons in the hypothalamic arcuate nucleus
inferred← citeshttps://doi.org/10.1016/j.npep.2024.102439openalex-snapshot
Effects of an herbal adaptogen feed-additive on feeding-related hypothalamic neuropeptides in chronic cyclic heat-stressed chickens
inferred← citeshttps://doi.org/10.1016/j.npep.2025.102582openalex-snapshot
ATP drives the leptin inhibition of voltage-gated calcium channels via AMPK in isolated neurons of arcuate nucleus in male rats
inferred← citeshttps://doi.org/10.1016/j.physbeh.2020.113039openalex-snapshot
Effects of metabolic state on the regulation of melanocortin circuits
inferred← citeshttps://doi.org/10.1016/j.ygcen.2017.05.016openalex-snapshot
Effects of chronic intracerebroventricular infusion of neurosecretory protein GL on body mass and food and water intake in chicks
inferred← citeshttps://doi.org/10.1038/s12276-021-00644-5openalex-snapshot
Hypothalamic primary cilium: A hub for metabolic homeostasis
inferred← citeshttps://doi.org/10.1038/s41582-023-00815-0openalex-snapshot
Neural cell state shifts and fate loss in ageing and age-related diseases
inferred← citeshttps://doi.org/10.1038/s44318-025-00503-3openalex-snapshot
FTO promotes weight gain via altering Kif1a splicing and axonal vesicle trafficking in AgRP neurons
inferred← citeshttps://doi.org/10.1038/s44319-024-00321-4openalex-snapshot
Interplay between the brain and adipose tissue: a metabolic conversation
inferred← citeshttps://doi.org/10.1109/tnsre.2024.3351312openalex-snapshot
Ultrasound Deep Brain Stimulation Regulates Food Intake and Body Weight in Mice
inferred← citeshttps://doi.org/10.1111/bph.16243openalex-snapshot
Adipose tissue as a therapeutic target for vascular damage in Alzheimer's disease
inferred← citeshttps://doi.org/10.1111/ejn.14490openalex-snapshot
Acute physical exercise increases APPL 1/ PI 3K signaling in the hypothalamus of lean mice
inferred← citeshttps://doi.org/10.1111/jne.12464openalex-snapshot
Glucose concentrations modulate brain‐derived neurotrophic factor responsiveness of neurones in the paraventricular nucleus of the hypothalamus
inferred← citeshttps://doi.org/10.1111/obr.13539openalex-snapshot
Glucocorticoids, stress and eating: The mediating role of appetite‐regulating hormones
inferred← citeshttps://doi.org/10.1152/ajpgi.00203.2023openalex-snapshot
Adiponectin affects ileal contractility of mouse preparations
inferred← citeshttps://doi.org/10.1155/2019/8208237openalex-snapshot
Effects of Highly Absorbable Curcumin in Patients with Impaired Glucose Tolerance and Non-Insulin-Dependent Diabetes Mellitus
inferred← citeshttps://doi.org/10.1155/ije/9009628openalex-snapshot
Adipokine in Metabolic Liver Disease: Adipo–Brain–Liver Cross talk
inferred← citeshttps://doi.org/10.1210/endocr/bqab009openalex-snapshot
Contributions of White and Brown Adipose Tissues to the Circadian Regulation of Energy Metabolism
inferred← citeshttps://doi.org/10.1210/endrev/bnab025openalex-snapshot
Arcuate Nucleus-Dependent Regulation of Metabolism—Pathways to Obesity and Diabetes Mellitus
inferred← citeshttps://doi.org/10.13005/bbra/2772openalex-snapshot
Association of +10211T/G (Rs17846866) Variant of Adiponectin Gene With Type 2 Diabetes Mellitus
inferred← citeshttps://doi.org/10.1371/journal.pone.0289020openalex-snapshot
Modified activity-based anorexia paradigm dampens chronic food restriction-induced hyperadiponectinemia in adolescent female mice
inferred← citeshttps://doi.org/10.1515/mr-2022-0002openalex-snapshot
Adiponectin: friend or foe in obesity and inflammation
inferred← citeshttps://doi.org/10.2139/ssrn.5178812openalex-snapshot
Atp Drives the Leptin Inhibition of Voltage-Gated Calcium Channels Via Ampk in Isolated Neurons of Arcuate Nucleus
inferred← citeshttps://doi.org/10.2147/dmso.s380577openalex-snapshot
Effects of the POMC System on Glucose Homeostasis and Potential Therapeutic Targets for Obesity and Diabetes
inferred← citeshttps://doi.org/10.3389/fendo.2023.1283298openalex-snapshot
Goldfish adiponectin: (I) molecular cloning, tissue distribution, recombinant protein expression, and novel function as a satiety factor in fish model
inferred← citeshttps://doi.org/10.3389/fnins.2018.01027openalex-snapshot
The Role of Leptin and Adiponectin in Obesity-Associated Cognitive Decline and Alzheimer’s Disease
inferred← citeshttps://doi.org/10.3389/fnins.2022.907508openalex-snapshot
Leptin and adiponectin regulate the activity of nuclei involved in sleep-wake cycle in male rats
inferred← citeshttps://doi.org/10.3389/fnins.2023.1145079openalex-snapshot
Activation of POMC neurons to adiponectin participating in EA-mediated improvement of high-fat diet IR mice
inferred← citeshttps://doi.org/10.3389/fpsyt.2017.00020openalex-snapshot
The Obesity–Impulsivity Axis: Potential Metabolic Interventions in Chronic Psychiatric Patients
inferred← citeshttps://doi.org/10.3390/ijms19113552openalex-snapshot
Hypothalamic AMPK as a Mediator of Hormonal Regulation of Energy Balance
inferred← citeshttps://doi.org/10.3390/ijms20225638openalex-snapshot
The Novel Perspectives of Adipokines on Brain Health
inferred← citeshttps://doi.org/10.3390/ijms21249375openalex-snapshot
Adiponectin in Chronic Kidney Disease
inferred← citeshttps://doi.org/10.3390/ijms22041587openalex-snapshot
Adiponectin Controls Nutrient Availability in Hypothalamic Astrocytes
inferred← citeshttps://doi.org/10.3390/ijms24021082openalex-snapshot
Defining the Molecular Mechanisms of the Relaxant Action of Adiponectin on Murine Gastric Fundus Smooth Muscle: Potential Translational Perspectives on Eating Disorder Management
inferred← citeshttps://doi.org/10.3390/ijms252312637openalex-snapshot
Should We Consider Neurodegeneration by Itself or in a Triangulation with Neuroinflammation and Demyelination? The Example of Multiple Sclerosis and Beyond
inferred← citeshttps://doi.org/10.3390/life13091812openalex-snapshot
Adiponectin Modulates Smooth Muscle Cell Morpho-Functional Properties in Murine Gastric Fundus via Sphingosine Kinase 2 Activation
inferred← citeshttps://doi.org/10.3390/metabo16080533openalex-snapshot
Adipose Tissue–Central Nervous System Axis in Obesity: Molecular Mechanisms, Inflammation, and Nutritional and Technological Implications
inferred← citeshttps://doi.org/10.3390/nu13072254openalex-snapshot
Metabolic Syndrome: Is It Time to Add the Central Nervous System?
inferred← citeshttps://doi.org/10.3390/nu13103387openalex-snapshot
The Controversial Role of Adiponectin in Appetite Regulation of Animals
inferred← citeshttps://doi.org/10.3390/nu15143120openalex-snapshot
The Effects of Ketogenic Diet on Insulin Sensitivity and Weight Loss, Which Came First: The Chicken or the Egg?
inferred← citeshttps://doi.org/10.3748/wjg.v26.i20.2472openalex-snapshot
Can adiponectin have an additional effect on the regulation of food intake by inducing gastric motor changes?
inferred← citeshttps://doi.org/10.70675/5d147ab4zad37z4f6bzac51z32a08efeaa51openalex-snapshot
Inter-organ communication in physiology and pathophysiology : a role for the ChREBP-FGF21 axis?
inferred← citeshttps://doi.org/10.7554/elife.25755openalex-snapshot
Plasticity of calcium-permeable AMPA glutamate receptors in Pro-opiomelanocortin neurons
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