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Colchicine prevents NSAID-induced small intestinal injury by inhibiting activation of the NLRP3 inflammasome

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1001/archderm.117.12.760openalex-snapshot
Treatment of Generalized Pustular Psoriasis With Methotrexate and Colchicine
inferredcites →https://doi.org/10.1007/bf00403737openalex-snapshot
Colchicine in generalized pustular psoriasis: Clinical response and antibody-dependent cytotoxicity by monocytes and neutrophils
inferredcites →https://doi.org/10.1007/s10620-012-2530-8openalex-snapshot
Role of Phospholipids in Protection of the GI Mucosa
inferredcites →https://doi.org/10.1007/s11926-002-0073-2openalex-snapshot
Update on colchicine and its mechanism of action
inferredcites →https://doi.org/10.1016/j.ajpath.2012.03.039openalex-snapshot
High Mobility Group Box 1 Promotes Small Intestinal Damage Induced by Nonsteroidal Anti-Inflammatory Drugs through Toll-Like Receptor 4
inferredcites →https://doi.org/10.1016/j.cell.2014.04.007openalex-snapshot
Mechanisms and Functions of Inflammasomes
inferredcites →https://doi.org/10.1016/j.cgh.2015.10.022openalex-snapshot
Proton Pump Inhibitors Increase Incidence of Nonsteroidal Anti-Inflammatory Drug–Induced Small Bowel Injury: A Randomized, Placebo-Controlled Trial
inferredcites →https://doi.org/10.1016/j.dld.2012.12.005openalex-snapshot
Risk factors for severe nonsteroidal anti-inflammatory drug-induced small intestinal damage
inferredcites →https://doi.org/10.1016/j.ejphar.2004.07.042openalex-snapshot
Mechanisms underlying intestinal injury induced by anti-inflammatory COX inhibitors
inferredcites →https://doi.org/10.1016/j.gie.2014.03.024openalex-snapshot
Risk factors for small-bowel mucosal breaks in chronic low-dose aspirin users: data from a prospective multicenter capsule endoscopy registry
inferredcites →https://doi.org/10.1016/j.immuni.2013.08.037openalex-snapshot
Mechanisms of NOD-like Receptor-Associated Inflammasome Activation
inferredcites →https://doi.org/10.1016/j.jbspin.2006.03.006openalex-snapshot
Colchicine today
inferredcites →https://doi.org/10.1016/s0002-9343(97)00211-8openalex-snapshot
Mechanisms of Ulcer Healing and Effects of Nonsteroidal Anti-inflammatory Drugs
inferredcites →https://doi.org/10.1016/s0140-6736(75)80031-6openalex-snapshot
Leucocyte movement and colchicine treatment in Behcet's disease
inferredcites →https://doi.org/10.1016/s0140-6736(77)92945-2openalex-snapshot
COLCHICINE IN BEHÇET'S DISEASE
inferredcites →https://doi.org/10.1016/s0960-9822(99)80085-2openalex-snapshot
Fever: Links with an ancient receptor
inferredcites →https://doi.org/10.1016/s1074-7613(04)00046-9openalex-snapshot
NALP3 Forms an IL-1β-Processing Inflammasome with Increased Activity in Muckle-Wells Autoinflammatory Disorder
inferredcites →https://doi.org/10.1016/s1097-2765(02)00599-3openalex-snapshot
The Inflammasome
inferredcites →https://doi.org/10.1016/s1542-3565(04)00603-2openalex-snapshot
Visible small-intestinal mucosal injury in chronic NSAID users
inferredcites →https://doi.org/10.1016/s1542-3565(04)00619-6openalex-snapshot
Video capsule endoscopy to prospectively assess small bowel injury with celecoxib, naproxen plus omeprazole, and placebo
inferredcites →https://doi.org/10.1038/mi.2015.89openalex-snapshot
Mechanisms of NLRP3 inflammasome activation and its role in NSAID-induced enteropathy
inferredcites →https://doi.org/10.1038/nature04515openalex-snapshot
Cryopyrin activates the inflammasome in response to toxins and ATP
inferredcites →https://doi.org/10.1038/nature04516openalex-snapshot
Gout-associated uric acid crystals activate the NALP3 inflammasome
inferredcites →https://doi.org/10.1038/nature08938openalex-snapshot
NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals
inferredcites →https://doi.org/10.1038/ni.1631openalex-snapshot
Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization
inferredcites →https://doi.org/10.1038/ni.2550openalex-snapshot
Microtubule-driven spatial arrangement of mitochondria promotes activation of the NLRP3 inflammasome
inferredcites →https://doi.org/10.1046/j.1365-2036.2000.00723.xopenalex-snapshot
Uncoupling of intestinal mitochondrial oxidative phosphorylation and inhibition of cyclooxygenase are required for the development of NSAID‐enteropathy in the rat
inferredcites →https://doi.org/10.1053/j.gastro.2004.04.003openalex-snapshot
The effects of aspirin on gastric mucosal integrity, surface hydrophobicity, and prostaglandin metabolism in cyclooxygenase knockout mice
inferredcites →https://doi.org/10.1053/j.gastro.2005.03.020openalex-snapshot
A Quantitative Analysis of NSAID-Induced Small Bowel Pathology by Capsule Enteroscopy
inferredcites →https://doi.org/10.1053/j.gastro.2011.06.075openalex-snapshot
Proton Pump Inhibitors Exacerbate NSAID-Induced Small Intestinal Injury by Inducing Dysbiosis
inferredcites →https://doi.org/10.1056/nejm197410312911803openalex-snapshot
A Controlled Trial of Colchicine in Preventing Attacks of Familial Mediterranean Fever
inferredcites →https://doi.org/10.1056/nejm197410312911804openalex-snapshot
Colchicine Therapy for Familial Mediterranean Fever
inferredcites →https://doi.org/10.1056/nejm198612043152304openalex-snapshot
A Prospective Trial of Colchicine for Primary Biliary Cirrhosis
inferredcites →https://doi.org/10.1067/mjd.2002.121028openalex-snapshot
Long-term suppression of chronic Sweet's syndrome with colchicine?
inferredcites →https://doi.org/10.1073/pnas.1008155107openalex-snapshot
Nanoparticles activate the NLR pyrin domain containing 3 (Nlrp3) inflammasome and cause pulmonary inflammation through release of IL-1α and IL-1β
inferredcites →https://doi.org/10.1084/jem.20110367openalex-snapshot
Mitochondrial reactive oxygen species drive proinflammatory cytokine production
inferredcites →https://doi.org/10.1111/j.1749-6632.2009.04674.xopenalex-snapshot
Colchicine Revisited
inferredcites →https://doi.org/10.1124/jpet.112.197475openalex-snapshot
Exacerbation of Nonsteroidal Anti-Inflammatory Drug-Induced Small Intestinal Lesions by Antisecretory Drugs in Rats: The Role of Intestinal Motility
inferredcites →https://doi.org/10.1126/science.1156995openalex-snapshot
Innate Immune Activation Through Nalp3 Inflammasome Sensing of Asbestos and Silica
inferredcites →https://doi.org/10.1136/gut.2007.125963openalex-snapshot
Non-steroidal anti-inflammatory drug-induced small intestinal damage is Toll-like receptor 4 dependent
inferredcites →https://doi.org/10.1136/gutjnl-2013-304713openalex-snapshot
Anti-tumour necrosis factor agents reduce non-steroidal anti-inflammatory drug-induced small bowel injury in rheumatoid arthritis patients
inferredcites →https://doi.org/10.1159/000190403openalex-snapshot
Evaluation of Small Bowel Injury in Patients with Rheumatoid Arthritis by Capsule Endoscopy: Effects of Anti-Rheumatoid Arthritis Drugs
inferredcites →https://doi.org/10.1159/000374106openalex-snapshot
NSAID-Induced Small Intestinal Damage - Roles of Various Pathogenic Factors
inferredcites →https://doi.org/10.1517/14656566.2010.529432openalex-snapshot
Colchicine for the treatment of gout
inferredcites →https://doi.org/10.2147/jpr.s75160openalex-snapshot
New insights into the use of currently available non-steroidal anti-inflammatory drugs
inferredcites →https://doi.org/10.3164/jcbn.10-73openalex-snapshot
Mitochondrial disorders in NSAIDs-induced small bowel injury

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.3897/pharmacia.70.e112550zenodo-depositor-declared
Comparison of treatment of COVID-19 with inhaled bromhexine, higher doses of colchicine and hymecromone with WHO-recommended paxlovid, molnupiravir, remdesivir, anti-IL-6 receptor antibodies and baricitinib
inferred← citeshttps://doi.org/10.1002/mco2.154openalex-snapshot
Inflammatory pathways in COVID‐19: Mechanism and therapeutic interventions
inferred← citeshttps://doi.org/10.1007/s00210-020-02034-6openalex-snapshot
Chloroquine/hydroxychloroquine: an inflammasome inhibitor in severe COVID-19?
inferred← citeshttps://doi.org/10.1007/s00535-019-01657-8openalex-snapshot
Current knowledge on non-steroidal anti-inflammatory drug-induced small-bowel damage: a comprehensive review
inferred← citeshttps://doi.org/10.1007/s10067-022-06050-0openalex-snapshot
Colchicine may become a new cornerstone therapy for coronary artery disease: a meta‐analysis of randomized controlled trials
inferred← citeshttps://doi.org/10.1007/s10620-025-09276-5openalex-snapshot
Berberine Prevents NSAID-Induced Small Intestinal Injury by Protecting Intestinal Barrier and Inhibiting Inflammasome-Associated Activation
inferred← citeshttps://doi.org/10.1007/s10753-024-02220-1openalex-snapshot
Colchicine Alleviates Interstitial Lung Disease in an Experimental Autoimmune Myositis Murine Model by Inhibiting the Formation of Neutrophil Extracellular Traps
inferred← citeshttps://doi.org/10.1007/s11886-021-01589-xopenalex-snapshot
Interleukin-1 and the NLRP3 Inflammasome in Pericardial Disease
inferred← citeshttps://doi.org/10.1016/j.atherosclerosis.2017.12.027openalex-snapshot
The NLRP3 inflammasome and the emerging role of colchicine to inhibit atherosclerosis-associated inflammation
inferred← citeshttps://doi.org/10.1016/j.cytogfr.2021.06.002openalex-snapshot
The NLRP3 inflammasome and COVID-19: Activation, pathogenesis and therapeutic strategies
inferred← citeshttps://doi.org/10.1016/j.ecoenv.2023.115173openalex-snapshot
Protective effects and mechanisms of N-acetylcysteine on indomethacin-induced intestinal injury in a porcine model
inferred← citeshttps://doi.org/10.1016/j.hlc.2020.11.010openalex-snapshot
The Role of Colchicine in Atherosclerotic Cardiovascular Disease
inferred← citeshttps://doi.org/10.1016/j.ijcard.2019.06.070openalex-snapshot
Colchicine inhibits endothelial inflammation via NLRP3/CRP pathway
inferred← citeshttps://doi.org/10.1016/j.intimp.2024.111656openalex-snapshot
Geraniin restricts inflammasome activation and macrophage pyroptosis by preventing the interaction between ASC and NLRP3 to exert anti-inflammatory effects
inferred← citeshttps://doi.org/10.1016/j.jjcc.2023.05.002openalex-snapshot
Prognostic value of high-sensitivity C-reactive protein among chronic kidney disease patients undergoing percutaneous coronary intervention
inferred← citeshttps://doi.org/10.1016/j.jmb.2021.167301openalex-snapshot
Pyroptosis-Induced Inflammation and Tissue Damage
inferred← citeshttps://doi.org/10.1016/j.phymed.2026.158064openalex-snapshot
Pseudoginsenoside F11 enhances YBX1-mediated transcriptional repression of PRPS2 to inhibit the stemness and pulmonary metastasis of triple- negative breast cancer
inferred← citeshttps://doi.org/10.1021/acsptsci.4c00695openalex-snapshot
Gastroprotective Effect of Linagliptin on Indomethacin-Induced Gastric Ulceration in Mice: Crosstalk Between Oxidative Stress and Inflammasome Pathways
inferred← citeshttps://doi.org/10.1038/mi.2017.19openalex-snapshot
Inflammasomes and intestinal inflammation
inferred← citeshttps://doi.org/10.1038/s41392-022-01043-6openalex-snapshot
Cell deaths: Involvement in the pathogenesis and intervention therapy of COVID-19
inferred← citeshttps://doi.org/10.1038/s41575-018-0054-1openalex-snapshot
Inflammasomes in the gastrointestinal tract: infection, cancer and gut microbiota homeostasis
inferred← citeshttps://doi.org/10.1038/s41598-017-12562-6openalex-snapshot
Baicalein ameliorates TNBS-induced colitis by suppressing TLR4/MyD88 signaling cascade and NLRP3 inflammasome activation in mice
inferred← citeshttps://doi.org/10.1080/01480545.2018.1530261openalex-snapshot
Gastroprotective effects of oleuropein and thymol on indomethacin-induced gastric ulcer in Sprague-Dawley rats
inferred← citeshttps://doi.org/10.1080/08923973.2022.2072327openalex-snapshot
Potential role of carvedilol in intestinal toxicity through NF-κB/iNOS/COX-2/TNF-α inflammatory signaling pathway in rats
inferred← citeshttps://doi.org/10.1089/jir.2022.0061openalex-snapshot
The Role of Inflammasomes in COVID-19: Potential Therapeutic Targets
inferred← citeshttps://doi.org/10.1093/cvr/cvaa211openalex-snapshot
Inflammation and cardiovascular diseases: lessons from seminal clinical trials
inferred← citeshttps://doi.org/10.1093/jrr/rraa062openalex-snapshot
Rosiglitazone ameliorates radiation-induced intestinal inflammation in rats by inhibiting NLRP3 inflammasome and TNF-α production
inferred← citeshttps://doi.org/10.1097/fjc.0000000000001553openalex-snapshot
Novel Therapeutic Insights Into the Treatment of Pericarditis: Targeting the Innate Immune System
inferred← citeshttps://doi.org/10.1111/bph.15229openalex-snapshot
The hidden role of NLRP3 inflammasome in obesity‐related COVID‐19 exacerbations: Lessons for drug repurposing
inferred← citeshttps://doi.org/10.1111/cpr.12868openalex-snapshot
Wedelolactone facilitates Ser/Thr phosphorylation of NLRP3 dependent on PKA signalling to block inflammasome activation and pyroptosis
inferred← citeshttps://doi.org/10.1111/jcmm.16798openalex-snapshot
Anti‐inflammatory mechanisms and research progress of colchicine in atherosclerotic therapy
inferred← citeshttps://doi.org/10.1111/jgh.15861openalex-snapshot
Pirfenidone prevents esophageal stricture by inhibiting nucleotide binding oligomerization domain like receptor protein 3 inflammasome activation
inferred← citeshttps://doi.org/10.1111/jgh.15973openalex-snapshot
The influence of different proton pump inhibitors and potassium‐competitive acid blockers on indomethacin‐induced small intestinal injury
inferred← citeshttps://doi.org/10.1139/cjpp-2020-0230openalex-snapshot
The possible protective effect of colchicine against liver damage induced by renal ischemia–reperfusion injury: role of Nrf2 and NLRP3 inflammasome
inferred← citeshttps://doi.org/10.1155/2020/9173530openalex-snapshot
Colchicine Alleviates Cholesterol Crystal-Induced Endothelial Cell Pyroptosis through Activating AMPK/SIRT1 Pathway
inferred← citeshttps://doi.org/10.1159/000511255openalex-snapshot
Effects of Colchicine on NSAID-Induced Severe Small Intestinal Damage: A Pilot Study
inferred← citeshttps://doi.org/10.1161/circinterventions.120.009127openalex-snapshot
Treating Inflammation Prior to Percutaneous Coronary Intervention
inferred← citeshttps://doi.org/10.1177/1753425919881502openalex-snapshot
Combinatory antibiotic treatment protects against experimental acute pancreatitis by suppressing gut bacterial translocation to pancreas and inhibiting NLRP3 inflammasome pathway
inferred← citeshttps://doi.org/10.1186/s13098-024-01369-xopenalex-snapshot
RETRACTED ARTICLE: Emerging insights into the role of IL-1 inhibitors and colchicine for inflammation control in type 2 diabetes
inferred← citeshttps://doi.org/10.1186/s40001-024-01836-1openalex-snapshot
The effect of colchicine on cancer risk in patients with immune-mediated inflammatory diseases: a time-dependent study based on the Taiwan’s National Health Insurance Research Database
inferred← citeshttps://doi.org/10.1371/journal.pone.0167486openalex-snapshot
Brucella Melitensis 16M Regulates the Effect of AIR Domain on Inflammatory Factors, Autophagy, and Apoptosis in Mouse Macrophage through the ROS Signaling Pathway
inferred← citeshttps://doi.org/10.1371/journal.pone.0242318openalex-snapshot
Colchicine reduces lung injury in experimental acute respiratory distress syndrome
inferred← citeshttps://doi.org/10.21203/rs.3.rs-4069157/v1openalex-snapshot
Colchicine alleviates interstitial lung disease in mice with experimental autoimmune myositis by inhibiting the formation of neutrophil extracellular traps
inferred← citeshttps://doi.org/10.2139/ssrn.4875557openalex-snapshot
Innovative Dual-Physical Bioreactor for Quantifying the Synergistic Effects of Electromechanical Coupling Stimulations on Cancer Cells
inferred← citeshttps://doi.org/10.2147/ijgm.s329810openalex-snapshot
Colchicine in Recently Hospitalized Patients with COVID-19: A Randomized Controlled Trial (COL-COVID)
inferred← citeshttps://doi.org/10.2174/0929867329666220906111550openalex-snapshot
Putative Therapeutic Impact of Inflammasome Inhibitors against COVID-19-Induced ARDS
inferred← citeshttps://doi.org/10.22541/au.159318474.49742538openalex-snapshot
The hidden role of NLRP3 inflammasome in diabesity-related COVID-19 exacerbations: lessons for drug repurposing
inferred← citeshttps://doi.org/10.3389/fcimb.2021.679396openalex-snapshot
Gut Microbiota in NSAID Enteropathy: New Insights From Inside
inferred← citeshttps://doi.org/10.3389/fimmu.2020.01021openalex-snapshot
Novel Coronavirus-Induced NLRP3 Inflammasome Activation: A Potential Drug Target in the Treatment of COVID-19
inferred← citeshttps://doi.org/10.3389/fimmu.2022.870627openalex-snapshot
Repositioning of the Angiotensin II Receptor Antagonist Candesartan as an Anti-Inflammatory Agent With NLRP3 Inflammasome Inhibitory Activity
inferred← citeshttps://doi.org/10.3389/fimmu.2026.1794782openalex-snapshot
From soluble uric acid to sodium urate crystal: immune metabolic inflammation driven by uric acid morphological transformation and mechanism-oriented therapy
inferred← citeshttps://doi.org/10.3389/fphar.2022.960140openalex-snapshot
Sanguinarine protects against indomethacin-induced small intestine injury in rats by regulating the Nrf2/NF-κB pathways
inferred← citeshttps://doi.org/10.3389/fphar.2026.1857470openalex-snapshot
Colchicine in atrial fibrillation: mechanisms, highlights, and current evidence
inferred← citeshttps://doi.org/10.3389/fphys.2023.1260774openalex-snapshot
Colchicine in atrial fibrillation: are old trees in bloom?
inferred← citeshttps://doi.org/10.3390/biomedicines11010113openalex-snapshot
Worsening Thrombotic Complication of Atherosclerotic Plaques Due to Neutrophils Extracellular Traps: A Systematic Review
inferred← citeshttps://doi.org/10.3390/cancers14194965openalex-snapshot
High Neutrophil-to-Lymphocyte Ratio Facilitates Cancer Growth—Currently Marketed Drugs Tadalafil, Isotretinoin, Colchicine, and Omega-3 to Reduce It: The TICO Regimen
inferred← citeshttps://doi.org/10.3390/molecules26164996openalex-snapshot
Promise of the NLRP3 Inflammasome Inhibitors in In Vivo Disease Models
inferred← citeshttps://doi.org/10.3390/ph15101168openalex-snapshot
Molecular Mechanisms of Inflammasome in Ischemic Stroke Pathogenesis
inferred← citeshttps://doi.org/10.34172/jre.2022.19065openalex-snapshot
Colchicine; An inflammasome inhibitor and a potential therapy in severe COVID19?
inferred← citeshttps://doi.org/10.4049/jimmunol.2300745openalex-snapshot
NLRP3 Inflammasomes: Dual Function in Infectious Diseases
inferred← citeshttps://doi.org/10.56499/jppres23.1819_12.2.296openalex-snapshot
Antifibrotic effects of colchicine on 3T3 cell line ischemia to mitigate detrimental remodeling
inferred← citeshttps://doi.org/10.6084/m9.figshare.25670180openalex-snapshot
Additional file 1 of The effect of colchicine on cancer risk in patients with immune-mediated inflammatory diseases: a time-dependent study based on the Taiwan’s National Health Insurance Research Database
inferred← citeshttps://doi.org/10.6084/m9.figshare.25670309openalex-snapshot
Additional file 2 of The effect of colchicine on cancer risk in patients with immune-mediated inflammatory diseases: a time-dependent study based on the Taiwan’s National Health Insurance Research Database
inferred← citeshttps://doi.org/10.6084/m9.figshare.26709809openalex-snapshot
Additional file 3 of The effect of colchicine on cancer risk in patients with immune-mediated inflammatory diseases: a time-dependent study based on the Taiwan’s National Health Insurance Research Database
inferred← citeshttps://doi.org/10.6084/m9.figshare.26709812openalex-snapshot
Additional file 4 of The effect of colchicine on cancer risk in patients with immune-mediated inflammatory diseases: a time-dependent study based on the Taiwan’s National Health Insurance Research Database
inferred← citeshttps://doi.org/10.6084/m9.figshare.26709815openalex-snapshot
Additional file 5 of The effect of colchicine on cancer risk in patients with immune-mediated inflammatory diseases: a time-dependent study based on the Taiwan’s National Health Insurance Research Database
inferred← citeshttps://doi.org/10.6084/m9.figshare.26709818openalex-snapshot
Additional file 6 of The effect of colchicine on cancer risk in patients with immune-mediated inflammatory diseases: a time-dependent study based on the Taiwan’s National Health Insurance Research Database
inferred← citeshttps://doi.org/10.70675/0f9a0e53z996fz45fcz8dc7z78be3486efcbopenalex-snapshot
Métabolites circulants induits par le conditionnement ischémique à distance et mécanismes cardioprotecteurs de la colchicine à la phase aigue de l'infarctus du myocarde
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