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An amino acid-based oral rehydration solution (AA-ORS) enhanced intestinal epithelial proliferation in mice exposed to radiation

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1001/dmp.2011.73openalex-snapshot
Literature Review and Global Consensus on Management of Acute Radiation Syndrome Affecting Nonhematopoietic Organ Systems
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Human cell models to study small intestinal functions: Recapitulation of the crypt-villus axis
inferredcites →https://doi.org/10.1002/aja.1001410407openalex-snapshot
Origin, differentiation and renewal of the four main epithelial cell types in the mouse small intestine V. Unitarian theory of the origin of the four epithelial cell types
inferredcites →https://doi.org/10.1002/jcp.1041630319openalex-snapshot
Cell cycle reentry of mammalian fibroblasts is accompanied by the sustained activation of P44mapk and P42mapk isoforms in the G1 phase and their inactivation at the G1/s transition
inferredcites →https://doi.org/10.1007/bf01991646openalex-snapshot
Amino acid absorption in jejunum and ileum in vivo — a kinetic comparison of function on surface area and regional bases
inferredcites →https://doi.org/10.1016/0277-5379(83)90143-8openalex-snapshot
A dose-surviving fraction curve for mouse colonic mucosa
inferredcites →https://doi.org/10.1016/j.canlet.2008.05.022openalex-snapshot
Inhibition of expression of anti-apoptotic protein Bcl-2 and induction of cell death in radioresistant human prostate adenocarcinoma cell line (PC-3) by methyl jasmonate
inferredcites →https://doi.org/10.1016/j.cub.2006.04.044openalex-snapshot
Continuous ERK Activation Downregulates Antiproliferative Genes throughout G1 Phase to Allow Cell-Cycle Progression
inferredcites →https://doi.org/10.1016/j.exphem.2008.06.009openalex-snapshot
Bone marrow sinusoidal endothelial cells undergo nonapoptotic cell death and are replaced by proliferating sinusoidal cells in situ to maintain the vascular niche following lethal irradiation
inferredcites →https://doi.org/10.1016/j.rpor.2011.06.001openalex-snapshot
Radiobiology of the acute radiation syndrome
inferredcites →https://doi.org/10.1016/j.stem.2008.03.009openalex-snapshot
PUMA Regulates Intestinal Progenitor Cell Radiosensitivity and Gastrointestinal Syndrome
inferredcites →https://doi.org/10.1016/j.stem.2012.09.009openalex-snapshot
Identifying the Stem Cell of the Intestinal Crypt: Strategies and Pitfalls
inferredcites →https://doi.org/10.1016/j.stem.2013.11.008openalex-snapshot
Lgr5+ Stem Cells Are Indispensable for Radiation-Induced Intestinal Regeneration
inferredcites →https://doi.org/10.1016/j.stem.2014.01.015openalex-snapshot
Radiation Redux: Reserve Intestinal Stem Cells Miss the Call to Duty
inferredcites →https://doi.org/10.1016/s0021-9258(18)42220-xopenalex-snapshot
Coordinate, biphasic activation of p44 mitogen-activated protein kinase and S6 kinase by growth factors in hamster fibroblasts. Evidence for thrombin-induced signals different from phosphoinositide turnover and adenylylcyclase inhibition.
inferredcites →https://doi.org/10.1016/s0092-8674(04)00046-7openalex-snapshot
Cell Death
inferredcites →https://doi.org/10.1016/s0960-9822(97)70074-5openalex-snapshot
Tumour suppressors: A developing role for p53?
inferredcites →https://doi.org/10.1038/356215a0openalex-snapshot
Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours
inferredcites →https://doi.org/10.1038/ncomms4494openalex-snapshot
Ionizing irradiation induces acute haematopoietic syndrome and gastrointestinal syndrome independently in mice
inferredcites →https://doi.org/10.1038/nrg1840openalex-snapshot
Organizing cell renewal in the intestine: stem cells, signals and combinatorial control
inferredcites →https://doi.org/10.1038/nrm2308openalex-snapshot
The BCL-2 protein family: opposing activities that mediate cell death
inferredcites →https://doi.org/10.1038/sj.gt.3303089openalex-snapshot
Intraesophageal MnSOD-plasmid liposome enhances engraftment and self-renewal of bone marrow derived progenitors of esophageal squamous epithelium
inferredcites →https://doi.org/10.1038/sj.onc.1203150openalex-snapshot
Damage-induced apoptosis in intestinal epithelia from bcl-2-null and bax-null mice: investigations of the mechanistic determinants of epithelial apoptosis in vivo
inferredcites →https://doi.org/10.1038/sj.onc.1206677openalex-snapshot
P53 and radiation responses
inferredcites →https://doi.org/10.1038/sj.onc.1207494openalex-snapshot
Dual effect of p53 on radiation sensitivity in vivo: p53 promotes hematopoietic injury, but protects from gastro-intestinal syndrome in mice
inferredcites →https://doi.org/10.1046/j.1365-2613.1997.280362.xopenalex-snapshot
The intestinal epithelial stem cell: the mucosal governor
inferredcites →https://doi.org/10.1046/j.1523-1755.2002.00406.xopenalex-snapshot
Na+/H+ exchange activity and NHE-3 expression in renal tubules from the spontaneously hypertensive rat
inferredcites →https://doi.org/10.1056/nejmra000365openalex-snapshot
Major Radiation Exposure — What to Expect and How to Respond
inferredcites →https://doi.org/10.1073/pnas.1118857109openalex-snapshot
The intestinal stem cell markers Bmi1 and Lgr5 identify two functionally distinct populations
inferredcites →https://doi.org/10.1073/pnas.92.19.8881openalex-snapshot
Association of mitogen-activated protein kinase with the microtubule cytoskeleton.
inferredcites →https://doi.org/10.1073/pnas.96.5.2110openalex-snapshot
Regulation of G 1 progression by the PTEN tumor suppressor protein is linked to inhibition of the phosphatidylinositol 3-kinase/Akt pathway
inferredcites →https://doi.org/10.1074/jbc.m708320200openalex-snapshot
MEK Signaling Is Required for Phosphorylation of eIF2α following Amino Acid Limitation of HepG2 Human Hepatoma Cells
inferredcites →https://doi.org/10.1080/09553009014552281openalex-snapshot
A Comprehensive Study of the Radiobiological Response of the Murine (BDF1) Small Intestine
inferredcites →https://doi.org/10.1080/15216540600957438openalex-snapshot
ERK1/2 MAP kinases in cell survival and apoptosis
inferredcites →https://doi.org/10.1093/emboj/16.8.1901openalex-snapshot
Interaction of MAP kinase with MAP kinase kinase: its possible role in the control of nucleocytoplasmic transport of MAP kinase
inferredcites →https://doi.org/10.1097/hp.0000000000000117openalex-snapshot
An Amino Acid Mixture Mitigates Radiation-induced Gastrointestinal Toxicity
inferredcites →https://doi.org/10.1097/hp.0b013e318266ee13openalex-snapshot
Acute Gastrointestinal Syndrome in High-Dose Irradiated Mice
inferredcites →https://doi.org/10.1101/gad.12.11.1551openalex-snapshot
Proteases to die for
inferredcites →https://doi.org/10.1101/gad.13.22.2905openalex-snapshot
Cellular survival: a play in three Akts
inferredcites →https://doi.org/10.1113/jphysiol.2007.129262openalex-snapshot
Acute inflammation alters bicarbonate transport in mouse ileum
inferredcites →https://doi.org/10.1126/science.1099513openalex-snapshot
Gastric Cancer Originating from Bone Marrow-Derived Cells
inferredcites →https://doi.org/10.1126/science.1106148openalex-snapshot
Phosphorylation and Regulation of Akt/PKB by the Rictor-mTOR Complex
inferredcites →https://doi.org/10.1126/science.1180794openalex-snapshot
Coexistence of Quiescent and Active Adult Stem Cells in Mammals
inferredcites →https://doi.org/10.1126/science.1213214openalex-snapshot
Interconversion Between Intestinal Stem Cell Populations in Distinct Niches
inferredcites →https://doi.org/10.1126/science.279.5351.710openalex-snapshot
Protein Kinase B Kinases That Mediate Phosphatidylinositol 3,4,5-Trisphosphate-Dependent Activation of Protein Kinase B
inferredcites →https://doi.org/10.1126/science.281.5381.1312openalex-snapshot
Caspases: Enemies Within
inferredcites →https://doi.org/10.1128/mcb.16.12.6623openalex-snapshot
Identification of a Cyclin-cdk2 Recognition Motif Present in Substrates and p21-Like Cyclin-Dependent Kinase Inhibitors
inferredcites →https://doi.org/10.1128/mcb.22.22.7831-7841.2002openalex-snapshot
Activation of Akt/Protein Kinase B Overcomes a G 2 /M Cell Cycle Checkpoint Induced by DNA Damage
inferredcites →https://doi.org/10.1152/ajpcell.00174.2013openalex-snapshot
Glucose stimulates calcium-activated chloride secretion in small intestinal cells
inferredcites →https://doi.org/10.1152/ajpgi.00415.2004openalex-snapshot
Role of short-chain fatty acids in colonic HCO3secretion
inferredcites →https://doi.org/10.1158/1541-7786.mcr-11-0052openalex-snapshot
Uncoupling p53 Functions in Radiation-Induced Intestinal Damage via PUMA and p21
inferredcites →https://doi.org/10.1161/01.hyp.37.5.1341openalex-snapshot
Contribution of Bcl-2, but Not Bcl-xL and Bax, to Antiapoptotic Actions of Hepatocyte Growth Factor in Hypoxia-Conditioned Human Endothelial Cells
inferredcites →https://doi.org/10.1177/2040622313510730openalex-snapshot
Radiation-induced small bowel disease: latest developments and clinical guidance
inferredcites →https://doi.org/10.1186/1741-7015-9-126openalex-snapshot
Acute radiation syndrome caused by accidental radiation exposure - therapeutic principles
inferredcites →https://doi.org/10.1634/theoncologist.2009-s104openalex-snapshot
Radioprotectors and Mitigators of Radiation-Induced Normal Tissue Injury
inferredcites →https://doi.org/10.1667/rr1880.1openalex-snapshot
Animal Models for Medical Countermeasures to Radiation Exposure
inferredcites →https://doi.org/10.1667/rr2330.1openalex-snapshot
Antioxidant Dietary Supplementation in Mice Exposed to Proton Radiation Attenuates Expression of Programmed Cell Death-Associated Genes
inferredcites →https://doi.org/10.18632/oncotarget.2209openalex-snapshot
Deregulation of the EGFR/PI3K/PTEN/Akt/mTORC1 pathway in breast cancer: possibilities for therapeutic intervention
inferredcites →https://doi.org/10.2741/a426openalex-snapshot
Lineage commitment and maturation of epithelial cells in the gut
inferredcites →https://doi.org/10.2741/karamopenalex-snapshot
Lineage commitment and maturation of epithelial cells in the gut
inferredcites →https://doi.org/10.3109/09553002.2011.583314openalex-snapshot
Radiation decreases murine small intestinal HCO 3 − secretion

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.4624343openalex-extracted
A Glucose-Free, Amino Acid-Based Oral Rehydration Solution for the Management of Acute Watery Diarrhoea in Young Children
inferred← citeshttps://doi.org/10.1002/jpen.1142openalex-snapshot
Efficacy of Glucose or Amino Acid–Based Commercial Beverages in Meeting Oral Rehydration Therapy Goals After Acute Hypertonic and Isotonic Dehydration
inferred← citeshttps://doi.org/10.1007/978-3-031-22265-8_18openalex-snapshot
Pelvic Radiation Disease and the Gastrointestinal Tract
inferred← citeshttps://doi.org/10.1007/s00018-019-03085-6openalex-snapshot
Role of mTORC1 in intestinal epithelial repair and tumorigenesis
inferred← citeshttps://doi.org/10.1007/s40279-025-02186-6openalex-snapshot
Sports Dietitians Australia and Ultra Sports Science Foundation Joint Position Statement: A Practitioner Guide to the Prevention and Management of Exercise-Associated Gastrointestinal Perturbations and Symptoms
inferred← citeshttps://doi.org/10.1016/j.apsb.2021.12.015openalex-snapshot
Milk-derived exosomes exhibit versatile effects for improved oral drug delivery
inferred← citeshttps://doi.org/10.1016/j.bpg.2020.101708openalex-snapshot
Chronic diarrhoea in an oncology patient – Clinical assessment and decision making
inferred← citeshttps://doi.org/10.1016/j.eclinm.2024.102630openalex-snapshot
Assessing safety and efficacy of a novel glucose-free amino acid oral rehydration solution for watery diarrhea management in children: a randomized, controlled, phase III trial
inferred← citeshttps://doi.org/10.1016/j.fsi.2025.110242openalex-snapshot
The defatted black soldier fly meal (Hermetia illucens) improved the pathogen resistance and gut health of Nile Tilapia (Oreochromis niloticus)
inferred← citeshttps://doi.org/10.1016/j.jsams.2024.05.010openalex-snapshot
Exertional heat stress promotes the presence of bacterial DNA in plasma: A counterbalanced randomised controlled trial
inferred← citeshttps://doi.org/10.1016/j.lfs.2022.120989openalex-snapshot
Raptor knockdown concurrently increases the electrical resistance and paracellular permeability of Caco-2 cell monolayers
inferred← citeshttps://doi.org/10.1016/j.lssr.2022.06.004openalex-snapshot
Inter-agency perspective: Translating advances in biomarker discovery and medical countermeasures development between terrestrial and space radiation environments
inferred← citeshttps://doi.org/10.1016/j.mehy.2019.03.023openalex-snapshot
Can an amino acid-based oral rehydration solution be effective in managing immune therapy-induced diarrhea?
inferred← citeshttps://doi.org/10.1038/s41467-022-32220-4openalex-snapshot
Ribosome impairment regulates intestinal stem cell identity via ZAKɑ activation
inferred← citeshttps://doi.org/10.1038/s41598-019-42778-7openalex-snapshot
GATA-type transcription factors play a vital role in radiation sensitivity of Cryptococcus neoformans by regulating the gene expression of specific amino acid permeases
inferred← citeshttps://doi.org/10.1093/ajcn/nqy005openalex-snapshot
Neither body mass nor sex influences beverage hydration index outcomes during randomized trial when comparing 3 commercial beverages
inferred← citeshttps://doi.org/10.1093/jn/nxaa025openalex-snapshot
An Amino Acid–Based Oral Rehydration Solution Regulates Radiation-Induced Intestinal Barrier Disruption in Mice
inferred← citeshttps://doi.org/10.1098/rstb.2025.0092openalex-snapshot
Essential is essential: a review evaluating the linkage of essential amino acid deficiency resulting from poor access to animal source foods with environmental enteric dysfunction and stunting
inferred← citeshttps://doi.org/10.1111/bjh.19268openalex-snapshot
Oral iron therapy: Current concepts and future prospects for improving efficacy and outcomes
inferred← citeshttps://doi.org/10.1113/ep093504openalex-snapshot
Plant‐protein supplementation improves thermoregulatory responses and ameliorates markers of intestinal damage during exercise in the heat
inferred← citeshttps://doi.org/10.1123/ijsnem.2023-0025openalex-snapshot
Amino Acid-Based Beverage Interventions Ameliorate Exercise-Induced Gastrointestinal Syndrome in Response to Exertional-Heat Stress: The Heat Exertion Amino Acid Technology (HEAAT) Study
inferred← citeshttps://doi.org/10.1152/japplphysiol.00072.2021openalex-snapshot
Nutritional considerations to counteract gastrointestinal permeability during exertional heat stress
inferred← citeshttps://doi.org/10.1155/2018/2819154openalex-snapshot
Regulation of Intestinal Epithelial Cells Properties and Functions by Amino Acids
inferred← citeshttps://doi.org/10.1177/0260106021991641openalex-snapshot
Are oral rehydration solutions optimized for treating diarrhea?
inferred← citeshttps://doi.org/10.1177/1098612x251334279openalex-snapshot
Voluntary acceptance of nutrient-enriched water supplement and promotion of water intake in clinically dehydrated cats
inferred← citeshttps://doi.org/10.1182/bloodadvances.2021005111openalex-snapshot
Four AAs increase DMT1 abundance in duodenal brush-border membrane vesicles and enhance iron absorption in iron-deprived mice
inferred← citeshttps://doi.org/10.1186/s12885-021-08315-4openalex-snapshot
Can an amino acid mixture alleviate gastrointestinal symptoms in neuroendocrine tumor patients?
inferred← citeshttps://doi.org/10.1371/journal.pone.0195615openalex-snapshot
Enteral resuscitation with oral rehydration solution to reduce acute kidney injury in burn victims: Evidence from a porcine model
inferred← citeshttps://doi.org/10.1371/journal.pone.0307809openalex-snapshot
Select amino acids recover cytokine-altered ENaC function in human bronchial epithelial cells
inferred← citeshttps://doi.org/10.14814/phy2.15681openalex-snapshot
Amino acid solution mitigates hypothermia response and intestinal damage following exertional heat stroke in male mice
inferred← citeshttps://doi.org/10.1515/revneuro-2018-0024openalex-snapshot
Gut dysbiosis, leaky gut, and intestinal epithelial proliferation in neurological disorders: towards the development of a new therapeutic using amino acids, prebiotics, probiotics, and postbiotics
inferred← citeshttps://doi.org/10.31557/apjcp.2021.22.1.301openalex-snapshot
Randomized Study of enterade® to Reduce Diarrhea in Patients Receiving High-Dose Chemotherapy and Autologous Hematopoietic Stem Cell Transplantation
inferred← citeshttps://doi.org/10.3389/fphar.2025.1522130openalex-snapshot
Selective amino acid formulation enhances anion secretion and restores function in cystic fibrosis mutations
inferred← citeshttps://doi.org/10.3389/fpubh.2024.1394023openalex-snapshot
Effects of radiation mitigating amino acid mixture on mice of different sexes
inferred← citeshttps://doi.org/10.3390/ijms25105566openalex-snapshot
Systematic-Narrative Hybrid Literature Review: Crosstalk between Gastrointestinal Renin–Angiotensin and Dopaminergic Systems in the Regulation of Intestinal Permeability by Tight Junctions
inferred← citeshttps://doi.org/10.3390/nu11071485openalex-snapshot
Osmolality of Commercially Available Oral Rehydration Solutions: Impact of Brand, Storage Time, and Temperature
inferred← citeshttps://doi.org/10.3892/wasj.2024.268openalex-snapshot
Identification of common biomarkers affecting patient survival in cancers
inferred← citeshttps://doi.org/10.3892/wasj.2024.278openalex-snapshot
Acidic pH at physiological salinity enhances the antitumor efficacy of lenvatinib, a drug targeting vascular endothelial growth factor receptors
inferred← citeshttps://doi.org/10.4103/1673-5374.235026openalex-snapshot
Neurodegenerative diseases are a function of matrix breakdown: how to rebuild extracellular matrix and intracellular matrix
inferred← citeshttps://doi.org/10.4292/wjgpt.v14.i5.39openalex-snapshot
Effectiveness of an amino acid beverage formulation in diarrhea-predominant irritable bowel syndrome: A pragmatic real-world study
inferred← citeshttps://doi.org/10.4292/wjgpt.v15.i1.90933openalex-snapshot
New paradigm of oral rehydration in patients affected by irritable bowel syndrome with chronic diarrhea
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