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Novel inhibitors of Mycobacterium tuberculosis GuaB2 identified by a target based high-throughput phenotypic screen

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/(sici)1097-0134(1997)1+<215::aid-prot29>3.0.co;2-qopenalex-snapshot

Flexible protein–ligand docking by global energy optimization in internal coordinates

inferredcites →https://doi.org/10.1002/(sici)1097-0134(1997)1+<215::aid-prot29>3.3.co;2-iopenalex-snapshot

Flexible protein–ligand docking by global energy optimization in internal coordinates

inferredcites →https://doi.org/10.1002/cmdc.201200428openalex-snapshot

Fueling Open‐Source Drug Discovery: 177 Small‐Molecule Leads against Tuberculosis

inferredcites →https://doi.org/10.1002/med.20104openalex-snapshot

Inosine monophosphate dehydrogenase (IMPDH) as a target in drug discovery

inferredcites →https://doi.org/10.1007/s10822-012-9547-0openalex-snapshot

Docking and scoring with ICM: the benchmarking results and strategies for improvement

inferredcites →https://doi.org/10.1016/j.drudis.2010.08.004openalex-snapshot

Ligand efficiency indices for an effective mapping of chemico-biological space: the concept of an atlas-like representation

inferredcites →https://doi.org/10.1016/s0140-6736(98)04022-7openalex-snapshot

Randomised controlled trial of self-supervised and directly observed treatment of tuberculosis

inferredcites →https://doi.org/10.1021/acsinfecdis.6b00102openalex-snapshot

The Inosine Monophosphate Dehydrogenase, GuaB2, Is a Vulnerable New Bactericidal Drug Target for Tuberculosis

inferredcites →https://doi.org/10.1021/acsinfecdis.6b00103openalex-snapshot

Essential but Not Vulnerable: Indazole Sulfonamides Targeting Inosine Monophosphate Dehydrogenase as Potential Leads againstMycobacterium tuberculosis

inferredcites →https://doi.org/10.1021/cr900021wopenalex-snapshot

IMP Dehydrogenase: Structure, Mechanism, and Inhibition

inferredcites →https://doi.org/10.1038/256331a0openalex-snapshot

IMP dehydrogenase, an enzyme linked with proliferation and malignancy

inferredcites →https://doi.org/10.1038/31159openalex-snapshot

Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence

inferredcites →https://doi.org/10.1038/513481aopenalex-snapshot

Chemistry: Chemical con artists foil drug discovery

inferredcites →https://doi.org/10.1038/nrd4001openalex-snapshot

Advances in the development of new tuberculosis drugs and treatment regimens

inferredcites →https://doi.org/10.1042/bj1830481openalex-snapshot

Inosine 5′-monophosphate dehydrogenase of Escherichia coli. Purification by affinity chromatography, subunit structure and inhibition by guanosine 5′-monophosphate

inferredcites →https://doi.org/10.1073/pnas.231275498openalex-snapshot

Comprehensive identification of conditionally essential genes in mycobacteria

inferredcites →https://doi.org/10.1074/jbc.m808541200openalex-snapshot

A Regulatory Role of the Bateman Domain of IMP Dehydrogenase in Adenylate Nucleotide Biosynthesis

inferredcites →https://doi.org/10.1093/cid/cir889openalex-snapshot

Totally Drug-Resistant Tuberculosis in India

inferredcites →https://doi.org/10.1093/nar/gkp916openalex-snapshot

PDBe: Protein Data Bank in Europe

inferredcites →https://doi.org/10.1093/nar/gkt1180openalex-snapshot

PDBe: Protein Data Bank in Europe

inferredcites →https://doi.org/10.1093/nar/gku397openalex-snapshot

PRISM: a web server and repository for prediction of protein–protein interactions and modeling their 3D complexes

inferredcites →https://doi.org/10.1099/mic.0.042549-0openalex-snapshot

Identification of novel diphenyl urea inhibitors of Mt-GuaB2 active against Mycobacterium tuberculosis

inferredcites →https://doi.org/10.1126/science.1106753openalex-snapshot

A Diarylquinoline Drug Active on the ATP Synthase of Mycobacterium tuberculosis

inferredcites →https://doi.org/10.1371/journal.pone.0033886openalex-snapshot

Identification of Novel Mt-Guab2 Inhibitor Series Active against M. tuberculosis

inferredcites →https://doi.org/10.1371/journal.pone.0138976openalex-snapshot

Mycobacterium tuberculosis IMPDH in Complexes with Substrates, Products and Antitubercular Compounds

inferredcites →https://doi.org/10.1378/chest.08-2427openalex-snapshot

Emergence of New Forms of Totally Drug-Resistant Tuberculosis Bacilli

inferredcites →https://doi.org/10.2217/fmb.10.50openalex-snapshot

Tmc207: the First Compound of A New class of Potent Anti-Tuberculosis Drugs

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.4765237openalex-extracted

New Synergistic Benzoquinone Scaffolds as Inhibitors of Mycobacterial Cytochrome Bc1 Complex to Treat Multi-Drug Resistant Tuberculosis

inferred← citeshttps://doi.org/10.1002/asia.202200125openalex-snapshot

Mutants of Helicobacter pylori IMPDH: Kinetics and in silico Studies to Determine the Structural and Functional Role of Key Amino Acids

inferred← citeshttps://doi.org/10.1007/978-3-030-05282-9_5openalex-snapshot

In Silico Structure-Based Prediction of Receptor–Ligand Binding Affinity: Current Progress and Challenges

inferred← citeshttps://doi.org/10.1007/978-981-95-3957-4_28openalex-snapshot

Synthetic Biology for Drug Discovery

inferred← citeshttps://doi.org/10.1016/j.bmcl.2018.04.045openalex-snapshot

Hit discovery of Mycobacterium tuberculosis inosine 5′-monophosphate dehydrogenase, GuaB2, inhibitors

inferred← citeshttps://doi.org/10.1016/j.bmcl.2024.130026openalex-snapshot

Discovery of potent dihydro-oxazinoquinolinone inhibitors of GuaB for the treatment of tuberculosis

inferred← citeshttps://doi.org/10.1016/j.copbio.2017.03.023openalex-snapshot

Novel and revisited approaches in antituberculosis drug discovery

inferred← citeshttps://doi.org/10.1016/j.ejmech.2019.04.027openalex-snapshot

Synthesis and Structure–Activity relationship of 1-(5-isoquinolinesulfonyl)piperazine analogues as inhibitors of Mycobacterium tuberculosis IMPDH

inferred← citeshttps://doi.org/10.1016/j.ejmech.2024.116479openalex-snapshot

New synergistic benzoquinone scaffolds as inhibitors of mycobacterial cytochrome bc1 complex to treat multi-drug resistant tuberculosis

inferred← citeshttps://doi.org/10.1016/j.mib.2017.11.017openalex-snapshot

Host–pathogen systems for early drug discovery against tuberculosis

inferred← citeshttps://doi.org/10.1017/s0031182017002037openalex-snapshot

Microbial protein targets: towards understanding and intervention

inferred← citeshttps://doi.org/10.1021/acs.jmedchem.7b01622openalex-snapshot

Fragment-Based Approach to Targeting Inosine-5′-monophosphate Dehydrogenase (IMPDH) from Mycobacterium tuberculosis

inferred← citeshttps://doi.org/10.1021/acs.jmedchem.7b01839openalex-snapshot

Expanding Benzoxazole-Based Inosine 5′-Monophosphate Dehydrogenase (IMPDH) Inhibitor Structure–Activity As Potential Antituberculosis Agents

inferred← citeshttps://doi.org/10.1021/acsinfecdis.3c00463openalex-snapshot

Identification of Chemical Scaffolds Targeting Drug-Resistant and Latent Mycobacterium tuberculosis through High-Throughput Whole-Cell Screening

inferred← citeshttps://doi.org/10.1021/acsinfecdis.6c00350openalex-snapshot

Development of GuaB Inhibitors to Treat Mycobacterium tuberculosis Infection

inferred← citeshttps://doi.org/10.1038/s41467-024-50933-6openalex-snapshot

Deciphering the allosteric regulation of mycobacterial inosine-5′-monophosphate dehydrogenase

inferred← citeshttps://doi.org/10.1038/s41557-024-01516-xopenalex-snapshot

Discovery of isoquinoline sulfonamides as allosteric gyrase inhibitors with activity against fluoroquinolone-resistant bacteria

inferred← citeshttps://doi.org/10.1038/s41586-025-09177-7openalex-snapshot

Targeting de novo purine biosynthesis for tuberculosis treatment

inferred← citeshttps://doi.org/10.1038/s41598-017-09642-yopenalex-snapshot

Inhibiting mycobacterial tryptophan synthase by targeting the inter-subunit interface

inferred← citeshttps://doi.org/10.1038/s41598-018-22228-6openalex-snapshot

Antimycobacterial drug discovery using Mycobacteria-infected amoebae identifies anti-infectives and new molecular targets

inferred← citeshttps://doi.org/10.1038/s41598-018-31157-3openalex-snapshot

Identification and characterization of aspartyl-tRNA synthetase inhibitors against Mycobacterium tuberculosis by an integrated whole-cell target-based approach

inferred← citeshttps://doi.org/10.1038/s41598-018-37490-xopenalex-snapshot

Identification of selective inhibitors of Helicobacter pylori IMPDH as a targeted therapy for the infection

inferred← citeshttps://doi.org/10.1039/d0md00261eopenalex-snapshot

Mycobacterial drug discovery

inferred← citeshttps://doi.org/10.1080/14756366.2025.2598479openalex-snapshot

Substrate cooperativity shapes competitive inhibitor responses in mycobacterial inosine 5′-monophosphate dehydrogenase

inferred← citeshttps://doi.org/10.1101/2021.08.05.455185openalex-snapshot

The mycobacterial guaB1 gene encodes a guanosine 5’-monophosphate reductase with a cystathione-β-synthase domain

inferred← citeshttps://doi.org/10.1111/febs.16448openalex-snapshot

The mycobacterial guaB1 gene encodes a guanosine 5′‐monophosphate reductase with a cystathionine‐β‐synthase domain

inferred← citeshttps://doi.org/10.1128/jb.00102-24openalex-snapshot

Differential effects of inosine monophosphate dehydrogenase (IMPDH/GuaB) inhibition in Acinetobacter baumannii and Escherichia coli

inferred← citeshttps://doi.org/10.1128/jb.00477-21openalex-snapshot

Union Is Strength: Target-Based and Whole-Cell High-Throughput Screens in Antibacterial Discovery

inferred← citeshttps://doi.org/10.1128/mbio.00897-24openalex-snapshot

Discovery of GuaB inhibitors with efficacy against Acinetobacter baumannii infection

inferred← citeshttps://doi.org/10.3389/fphar.2024.1329011openalex-snapshot

A journey into the regulatory secrets of the de novo purine nucleotide biosynthesis

inferred← citeshttps://doi.org/10.3390/ijms231810669openalex-snapshot

Fragment-Based Drug Discovery against Mycobacteria: The Success and Challenges

inferred← citeshttps://doi.org/10.3390/ijms27114829openalex-snapshot

The Spermidine Synthase Gene as a Reporter of Transcription Inhibition in Escherichia coli

inferred← citeshttps://doi.org/10.5772/intechopen.82374openalex-snapshot

Computational Deorphaning of Mycobacterium tuberculosis Targets

inferred← citeshttps://doi.org/10.70675/2db6eaa8z1907z4401z9f4bzd077bc99bdebopenalex-snapshot

Enzymes de la voie de biosynthèse de novo des nucléotides puriques chez les bactéries : caractérisation et rôle physiologique

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