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Aptamer-PEG-modified Fe3O4@Mn as a novel T1- and T2- dual-model MRI contrast agent targeting hypoxia-induced cancer stem cells

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1 of the 43 references listed on this page is in the Retraction Watch database as retracted (export 2026-11-04): 10.1073/pnas.0909353106 (notice 2023-04-26).

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/adma.201203169openalex-snapshot
A Synergistically Enhanced T1–T2 Dual‐Modal Contrast Agent
inferredcites →https://doi.org/10.1002/cmr.a.21249openalex-snapshot
Super‐resolution in magnetic resonance imaging: A review
inferredcites →https://doi.org/10.1002/stem.2114openalex-snapshot
Concise Review: Stem Cells in Pancreatic Cancer: From Concept to Translation
inferredcites →https://doi.org/10.1007/s11051-014-2678-6openalex-snapshot
T1–T2 Dual-modal MRI contrast agents based on superparamagnetic iron oxide nanoparticles with surface attached gadolinium complexes
inferredcites →https://doi.org/10.1016/j.addr.2015.08.005openalex-snapshot
Tumor microenvironment for cancer stem cells
inferredcites →https://doi.org/10.1016/j.biomaterials.2011.03.018openalex-snapshot
Targeted dual-contrast T1- and T2-weighted magnetic resonance imaging of tumors using multifunctional gadolinium-labeled superparamagnetic iron oxide nanoparticles
inferredcites →https://doi.org/10.1016/j.biomaterials.2015.11.010openalex-snapshot
Polydopamine-based coordination nanocomplex for T1/T2 dual mode magnetic resonance imaging-guided chemo-photothermal synergistic therapy
inferredcites →https://doi.org/10.1016/j.biomaterials.2016.05.054openalex-snapshot
Redoxable heteronanocrystals functioning magnetic relaxation switch for activatable T1 and T2 dual-mode magnetic resonance imaging
inferredcites →https://doi.org/10.1016/j.bmcl.2012.02.071openalex-snapshot
Development of hypoxia-sensitive Gd3+-based MRI contrast agents
inferredcites →https://doi.org/10.1016/j.clon.2014.02.002openalex-snapshot
The Meaning, Measurement and Modification of Hypoxia in the Laboratory and the Clinic
inferredcites →https://doi.org/10.1016/j.mam.2015.09.004openalex-snapshot
Dynamic regulation of stem cell specification and maintenance by hypoxia-inducible factors
inferredcites →https://doi.org/10.1016/j.msec.2013.07.012openalex-snapshot
Contrast agents for MRI
inferredcites →https://doi.org/10.1016/j.saa.2012.05.033openalex-snapshot
Synthesis, characterization, cell imaging and anti-tumor activity of multifunctional nanoparticles
inferredcites →https://doi.org/10.1016/j.semcancer.2014.07.001openalex-snapshot
Cancer stem cells, cancer cell plasticity and radiation therapy
inferredcites →https://doi.org/10.1016/j.stem.2011.02.006openalex-snapshot
Targeting HIF1α Eliminates Cancer Stem Cells in Hematological Malignancies
inferredcites →https://doi.org/10.1016/j.stem.2015.02.015openalex-snapshot
The Cancer Stem Cell Niche: How Essential Is the Niche in Regulating Stemness of Tumor Cells?
inferredcites →https://doi.org/10.1016/j.tips.2012.01.005openalex-snapshot
Hypoxia-inducible factors: mediators of cancer progression and targets for cancer therapy
inferredcites →https://doi.org/10.1016/j.yexmp.2009.01.004openalex-snapshot
Discovery and development of the G-rich oligonucleotide AS1411 as a novel treatment for cancer
inferredcites →https://doi.org/10.1021/ar200085copenalex-snapshot
Theranostic Magnetic Nanoparticles
inferredcites →https://doi.org/10.1021/nn405977topenalex-snapshot
T 1 and T 2 Dual-Mode MRI Contrast Agent for Enhancing Accuracy by Engineered Nanomaterials
inferredcites →https://doi.org/10.1021/nn503491eopenalex-snapshot
Epirubicin-Adsorbed Nanodiamonds Kill Chemoresistant Hepatic Cancer Stem Cells
inferredcites →https://doi.org/10.1021/nn507494popenalex-snapshot
Aptamer Nanomedicine for Cancer Therapeutics: Barriers and Potential for Translation
inferredcites →https://doi.org/10.1038/cddis.2011.123openalex-snapshot
Cancer metabolism: current perspectives and future directions
inferredcites →https://doi.org/10.1038/nbt.2612openalex-snapshot
Image-based analysis of lipid nanoparticle–mediated siRNA delivery, intracellular trafficking and endosomal escape
inferredcites →https://doi.org/10.1038/nm0909-1010openalex-snapshot
Cancer stem cells: mirage or reality?
inferredcites →https://doi.org/10.1038/nrc3064openalex-snapshot
Targeting hypoxia in cancer therapy
inferredcites →https://doi.org/10.1038/nrm1940openalex-snapshot
Harnessing actin dynamics for clathrin-mediated endocytosis
inferredcites →https://doi.org/10.1038/nrmicro1458openalex-snapshot
Aptamers come of age – at last
inferredcites →https://doi.org/10.1038/onc.2016.11openalex-snapshot
EGFR-targeted mAb therapy modulates autophagy in head and neck squamous cell carcinoma through NLRX1–TUFM protein complex
inferredcites →https://doi.org/10.1038/onc.2016.119openalex-snapshot
Hypoxia-induced oxidative stress promotes MUC4 degradation via autophagy to enhance pancreatic cancer cells survival
inferredcites →https://doi.org/10.1038/sj.bjc.6605551openalex-snapshot
Hypoxia inducible factors in cancer stem cells
inferredcites →https://doi.org/10.1073/pnas.0909353106openalex-snapshot
RETRACTED: Acriflavine inhibits HIF-1 dimerization, tumor growth, and vascularization
inferredcites →https://doi.org/10.1134/s0006297908050118openalex-snapshot
Transport proteins of the ABC family and multidrug resistance of tumor cells
inferredcites →https://doi.org/10.1158/0008-5472.can-15-2062openalex-snapshot
Oxygen-Enhanced MRI Accurately Identifies, Quantifies, and Maps Tumor Hypoxia in Preclinical Cancer Models
inferredcites →https://doi.org/10.1158/1078-0432.ccr-13-3434openalex-snapshot
Qualification of a Noninvasive Magnetic Resonance Imaging Biomarker to Assess Tumor Oxygenation
inferredcites →https://doi.org/10.1166/jbn.2015.2042openalex-snapshot
Biocompatible Low-Retention Superparamagnetic Iron Oxide Nanoclusters as Contrast Agents for Magnetic Resonance Imaging of Liver Tumor
inferredcites →https://doi.org/10.1186/1475-2867-13-119openalex-snapshot
Role of the Hypoxia-inducible factor-1 alpha induced autophagy in the conversion of non-stem pancreatic cancer cells into CD133+ pancreatic cancer stem-like cells
inferredcites →https://doi.org/10.18632/oncotarget.7229openalex-snapshot
Targeting hypoxic response for cancer therapy
inferredcites →https://doi.org/10.2147/ijnopenalex-snapshot
International Journal of Nanomedicine
inferredcites →https://doi.org/10.2147/ijn.s76501openalex-snapshot
Nanoparticles in magnetic resonance imaging: from simple to dual contrast agents
inferredcites →https://doi.org/10.3389/fgene.2012.00234openalex-snapshot
Current Progress of RNA Aptamer-Based Therapeutics
inferredcites →https://doi.org/10.3389/fonc.2012.00209openalex-snapshot
Tumor budding cells, cancer stem cells and epithelial-mesenchymal transition-type cells in pancreatic cancer
inferredcites →https://doi.org/10.3892/ijo.2011.1207openalex-snapshot
Hypoxia induces CD133 expression in human lung cancer cells by up-regulation of OCT3/4 and SOX2

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.4784873openalex-extracted
Multimodal Lanthanide Vanadate-Based Nanoparticles for T1 -T2 MRI and Nir Luminescent Imaging
inferred← citeshttps://doi.org/10.2139/ssrn.4797058openalex-extracted
Multimodal Lanthanide Vanadate-Based Nanoparticles for T1 -T2 MRI and Nir Luminescent Imaging
inferred← citeshttps://doi.org/10.1002/adhm.201801158openalex-snapshot
Molecular Engineering of Functional Nucleic Acid Nanomaterials toward In Vivo Applications
inferred← citeshttps://doi.org/10.1007/978-981-33-4838-7_9openalex-snapshot
Aptamers for the Diagnosis of Malign Tumors
inferred← citeshttps://doi.org/10.1007/s00604-019-4035-zopenalex-snapshot
Colorimetric determination of the early biomarker hypoxia-inducible factor-1 alpha (HIF-1α) in circulating exosomes by using a gold seed-coated with aptamer-functionalized Au@Au core-shell peroxidase mimic
inferred← citeshttps://doi.org/10.1016/b978-0-12-816386-3.00034-xopenalex-snapshot
Aptamers for Molecular Imaging
inferred← citeshttps://doi.org/10.1016/b978-0-443-19142-8.00013-9openalex-snapshot
Aptamer-mediated nano-therapy for pancreatic cancer
inferred← citeshttps://doi.org/10.1016/j.aca.2025.344863openalex-snapshot
Ferritin-encapsulated iron oxide nanoparticles for dual-mode MRI contrast enhancement and targeted cancer imaging
inferred← citeshttps://doi.org/10.1016/j.addr.2018.04.005openalex-snapshot
Aptamers as targeting ligands and therapeutic molecules for overcoming drug resistance in cancers
inferred← citeshttps://doi.org/10.1016/j.addr.2018.08.004openalex-snapshot
Application of aptamers for in vivo molecular imaging and theranostics
inferred← citeshttps://doi.org/10.1016/j.apmt.2024.102087openalex-snapshot
A review of design criteria for cancer-targeted, nanoparticle-based MRI contrast agents
inferred← citeshttps://doi.org/10.1016/j.inoche.2025.114713openalex-snapshot
Synthesis and characterization of manganese-loaded core-shell SPIONs for dual T1/T2 weighted MR imaging applications in breast cancer
inferred← citeshttps://doi.org/10.1016/j.jallcom.2024.175647openalex-snapshot
Lanthanide vanadate-based nanoparticles as multimodal T1 -T2 MRI contrast agent and NIR luminescent imaging probe
inferred← citeshttps://doi.org/10.1016/j.jallcom.2024.176581openalex-snapshot
Factors controlling the organ-specific T1 contrast effect of silica nanoparticles co-doped with both Mn2+ ions and oleate-coated iron oxides
inferred← citeshttps://doi.org/10.1016/j.matpr.2023.07.017openalex-snapshot
Structural, magnetic and optical properties of Fe3O4@NaGdF4 core-shell composite
inferred← citeshttps://doi.org/10.1016/j.nano.2018.04.012openalex-snapshot
Dual T1 and T2 weighted magnetic resonance imaging based on Gd3+ loaded bioinspired melanin dots
inferred← citeshttps://doi.org/10.1021/acs.bioconjchem.9b00448openalex-snapshot
Nanoparticle Interactions with the Tumor Microenvironment
inferred← citeshttps://doi.org/10.1021/acs.chemrev.8b00401openalex-snapshot
Versatile Types of Organic/Inorganic Nanohybrids: From Strategic Design to Biomedical Applications
inferred← citeshttps://doi.org/10.1021/acsabm.2c00128openalex-snapshot
Recent Advances in Self-Assembled DNA Nanostructures for Bioimaging
inferred← citeshttps://doi.org/10.1021/acsami.9b14394openalex-snapshot
Peptide-Decorated Ultrasmall Superparamagnetic Nanoparticles as Active Targeting MRI Contrast Agents for Ovarian Tumors
inferred← citeshttps://doi.org/10.1021/acsbiomaterials.7b00326openalex-snapshot
MemHsp70 Receptor-mediated Multifunctional Ordered Mesoporous Carbon Nanospheres for Photoacoustic Imaging-Guided Synergistic Targeting Trimodal Therapy
inferred← citeshttps://doi.org/10.1039/c7ra04903jopenalex-snapshot
Feasibility of USPIOs for T 1 -weighted MR molecular imaging of tumor receptors
inferred← citeshttps://doi.org/10.1039/c8nr03054eopenalex-snapshot
Three-dimensional angiography fused with CT/MRI for multimodal imaging of nanoparticles based on Ba 4 Yb 3 F 17 :Lu 3+ ,Gd 3+
inferred← citeshttps://doi.org/10.1039/d0an00397bopenalex-snapshot
A novel fluorescence method for the rapid and effective detection of Listeria monocytogenes using aptamer-conjugated magnetic nanoparticles and aggregation-induced emission dots
inferred← citeshttps://doi.org/10.1039/d0sc05112hopenalex-snapshot
Ex vivo identification of circulating tumor cells in peripheral blood by fluorometric “turn on” aptamer nanoparticles
inferred← citeshttps://doi.org/10.1039/d0tb00552eopenalex-snapshot
Magnetic nanoparticles applied in targeted therapy and magnetic resonance imaging: crucial preparation parameters, indispensable pre-treatments, updated research advancements and future perspectives
inferred← citeshttps://doi.org/10.1039/d1tb01392kopenalex-snapshot
Se-modified gold nanorods for enhancing the efficiency of photothermal therapy: avoiding the off-target problem induced by biothiols
inferred← citeshttps://doi.org/10.1039/d2ay00384hopenalex-snapshot
Development of a fluorescent test strip sensor based on surface positively-charged magnetic bead separation for the detection of Listeria monocytogenes
inferred← citeshttps://doi.org/10.1039/d4sc04849kopenalex-snapshot
The role of responsive MRI probes in the past and the future of molecular imaging
inferred← citeshttps://doi.org/10.1080/1061186x.2024.2373306openalex-snapshot
Aptamers: ushering in new hopes in targeted glioblastoma therapy
inferred← citeshttps://doi.org/10.1088/1748-605x/abddf4openalex-snapshot
Recent advances in development of nanomedicines for multiple sclerosis diagnosis
inferred← citeshttps://doi.org/10.1155/2019/3687537openalex-snapshot
Imaging Characteristics of USPIO Nanoparticles (<5 nm) as MR Contrast Agent In Vitro and in the Liver of Rats
inferred← citeshttps://doi.org/10.1155/2021/6050795openalex-snapshot
Advances in Magnetic Nanoparticle-Driven Delivery of Gene Therapies towards Prostate Cancer
inferred← citeshttps://doi.org/10.1186/s40824-021-00244-4openalex-snapshot
Design and clinical developments of aptamer-drug conjugates for targeted cancer therapy
inferred← citeshttps://doi.org/10.18632/oncotarget.24902openalex-snapshot
Selection of a novel CD19 aptamer for targeted delivery of doxorubicin to lymphoma cells
inferred← citeshttps://doi.org/10.2147/ijn.s171804openalex-snapshot
Nitroxide-radicals–modified gold nanorods for in vivo CT/MRI-guided photothermal cancer therapy
inferred← citeshttps://doi.org/10.2147/ijn.s548825openalex-snapshot
Strategies for Pancreatic Cancer-Responsive Nanodrug Platforms Targeting Tumor Hypoxic Environments
inferred← citeshttps://doi.org/10.3390/bios12070478openalex-snapshot
Dual-Mode Tumor Imaging Using Probes That Are Responsive to Hypoxia-Induced Pathological Conditions
inferred← citeshttps://doi.org/10.3390/ijms22169101openalex-snapshot
Neuroblastoma GD2 Expression and Computational Analysis of Aptamer-Based Bioaffinity Targeting
inferred← citeshttps://doi.org/10.3390/ijms24021524openalex-snapshot
Cannot Target What Cannot Be Seen: Molecular Imaging of Cancer Stem Cells
inferred← citeshttps://doi.org/10.3390/mi13030436openalex-snapshot
Multivalent Aptamer Approach: Designs, Strategies, and Applications
inferred← citeshttps://doi.org/10.3390/ph11030071openalex-snapshot
Targeted Molecular Imaging Using Aptamers in Cancer
inferred← citeshttps://doi.org/10.5772/intechopen.100788openalex-snapshot
Industrial Applications of Ionic Liquids
inferred← citeshttps://doi.org/10.5772/intechopen.107948openalex-snapshot
Iron-Based Ionic Liquids for Magnetic Resonance Imaging Application
inferred← citeshttps://doi.org/10.70675/2097d129z95aaz45f5zbf91z199fddefb42copenalex-snapshot
Identification de nouvelles sondes moléculaires contre des biomarqueurs des maladies neurodégénératives
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