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Blubber transcriptome response to acute stress axis activation involves transient changes in adipogenesis and lipolysis in a fasting-adapted marine mammal

https://doi.org/10.1038/srep42110
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/cphy.c150013openalex-snapshot
Integrative Physiology of Fasting
inferredcites →https://doi.org/10.1007/978-1-4614-0965-6_2openalex-snapshot
Adipocyte Differentiation
inferredcites →https://doi.org/10.1007/978-1-4614-0965-6_4openalex-snapshot
White Adipose Tissue
inferredcites →https://doi.org/10.1007/978-1-4939-2895-8_2openalex-snapshot
Molecular Biology of Glucocorticoid Signaling
inferredcites →https://doi.org/10.1007/978-3-642-29056-5_19openalex-snapshot
Fasting Physiology of the Pinnipeds: The Challenges of Fasting While Maintaining High Energy Expenditure and Nutrient Delivery for Lactation
inferredcites →https://doi.org/10.1007/s00360-015-0901-0openalex-snapshot
Stress physiology in marine mammals: how well do they fit the terrestrial model?
inferredcites →https://doi.org/10.1007/s11103-012-9885-2openalex-snapshot
miRDeepFinder: a miRNA analysis tool for deep sequencing of plant small RNAs
inferredcites →https://doi.org/10.1016/j.cell.2014.04.038openalex-snapshot
Glucocorticoid Receptor Function Regulated by Coordinated Action of the Hsp90 and Hsp70 Chaperone Cycles
inferredcites →https://doi.org/10.1016/j.cmet.2011.01.001openalex-snapshot
Crosstalk between Glucocorticoid Receptor and Nutritional Sensor mTOR in Skeletal Muscle
inferredcites →https://doi.org/10.1016/j.cmet.2013.11.013openalex-snapshot
SIRT5 Regulates the Mitochondrial Lysine Succinylome and Metabolic Networks
inferredcites →https://doi.org/10.1016/j.mce.2011.03.010openalex-snapshot
Characterization of murine melanocortin receptors mediating adipocyte lipolysis and examination of signalling pathways involved
inferredcites →https://doi.org/10.1016/j.metabol.2011.06.012openalex-snapshot
The effects of glucocorticoids on adipose tissue lipid metabolism
inferredcites →https://doi.org/10.1016/j.tins.2007.10.005openalex-snapshot
The coming out of the brain mineralocorticoid receptor
inferredcites →https://doi.org/10.1016/j.tree.2004.03.008openalex-snapshot
Physiological stress in ecology: lessons from biomedical research
inferredcites →https://doi.org/10.1016/j.ygcen.2014.04.024openalex-snapshot
Metabolic responses to adrenocorticotropic hormone (ACTH) vary with life-history stage in adult male northern elephant seals
inferredcites →https://doi.org/10.1016/j.ygcen.2017.08.001openalex-snapshot
Variation in adrenal and thyroid hormones with life-history stage in juvenile northern elephant seals (Mirounga angustirostris)
inferredcites →https://doi.org/10.1023/a:1009968113079openalex-snapshot
inferredcites →https://doi.org/10.1038/ng.3198openalex-snapshot
Convergent evolution of the genomes of marine mammals
inferredcites →https://doi.org/10.1038/nm.4115openalex-snapshot
Genetic identification of thiosulfate sulfurtransferase as an adipocyte-expressed antidiabetic target in mice selected for leanness
inferredcites →https://doi.org/10.1038/nmeth.3176openalex-snapshot
Fast and sensitive protein alignment using DIAMOND
inferredcites →https://doi.org/10.1038/nprot.2008.211openalex-snapshot
Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources
inferredcites →https://doi.org/10.1038/nprot.2013.084openalex-snapshot
De novo transcript sequence reconstruction from RNA-Seq: reference generation and analysis with Trinity
inferredcites →https://doi.org/10.1038/nrg2484openalex-snapshot
RNA-Seq: a revolutionary tool for transcriptomics
inferredcites →https://doi.org/10.1073/pnas.1121060109openalex-snapshot
Kruppel-like factor 15 regulates skeletal muscle lipid flux and exercise adaptation
inferredcites →https://doi.org/10.1074/jbc.c800241200openalex-snapshot
FoxO1 Controls Insulin-dependent Adipose Triglyceride Lipase (ATGL) Expression and Lipolysis in Adipocytes
inferredcites →https://doi.org/10.1086/589108openalex-snapshot
Stratification, Composition, and Function of Marine Mammal Blubber: The Ecology of Fatty Acids in Marine Mammals
inferredcites →https://doi.org/10.1086/680079openalex-snapshot
Adipose Triglyceride Lipase, Not Hormone-Sensitive Lipase, Is the Primary Lipolytic Enzyme in Fasting Elephant Seals (Mirounga angustirostris)
inferredcites →https://doi.org/10.1093/bioinformatics/btu170openalex-snapshot
Trimmomatic: a flexible trimmer for Illumina sequence data
inferredcites →https://doi.org/10.1093/bioinformatics/btv351openalex-snapshot
BUSCO: assessing genome assembly and annotation completeness with single-copy orthologs
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Overcoming the challenges of studying conservation physiology in large whales: a review of available methods
inferredcites →https://doi.org/10.1093/conphys/cou023openalex-snapshot
Measures of physiological stress: a transparent or opaque window into the status, management and conservation of species?
inferredcites →https://doi.org/10.1093/conphys/cov004openalex-snapshot
Adrenal sensitivity to stress is maintained despite variation in baseline glucocorticoids in moulting seals
inferredcites →https://doi.org/10.1093/hmg/10.17.1753openalex-snapshot
Molecular scanning of the human sorbin and SH3-domain-containing-1 (SORBS1) gene: positive association of the T228A polymorphism with obesity and type 2 diabetes
inferredcites →https://doi.org/10.1093/hmg/ddn035openalex-snapshot
Insulin receptor and lipid metabolism pathology in ataxin-2 knock-out mice
inferredcites →https://doi.org/10.1093/nar/29.9.e45openalex-snapshot
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The GeneMANIA prediction server: biological network integration for gene prioritization and predicting gene function
inferredcites →https://doi.org/10.1093/nar/gkv1077openalex-snapshot
Bovine Genome Database: new tools for gleaning function from theBos taurusgenome
inferredcites →https://doi.org/10.1096/fj.06-7970comopenalex-snapshot
Pivotal role of the mineralocorticoid receptor in corticosteroid‐induced adipogenesis
inferredcites →https://doi.org/10.1101/035642openalex-snapshot
Establishing evidenced-based best practice for the de novo assembly and evaluation of transcriptomes from non-model organisms
inferredcites →https://doi.org/10.1101/gr.1239303openalex-snapshot
Cytoscape: A Software Environment for Integrated Models of Biomolecular Interaction Networks
inferredcites →https://doi.org/10.1101/gr.196469.115openalex-snapshot
TransRate: reference-free quality assessment of de novo transcriptome assemblies
inferredcites →https://doi.org/10.1109/mcse.2014.80openalex-snapshot
XSEDE: Accelerating Scientific Discovery
inferredcites →https://doi.org/10.1128/mcb.01584-12openalex-snapshot
Insulin Inhibits Lipolysis in Adipocytes via the Evolutionarily Conserved mTORC1-Egr1-ATGL-Mediated Pathway
inferredcites →https://doi.org/10.1146/annurev.nutr.21.1.141openalex-snapshot
T HE R OLE OF C/EBP IN N UTRIENT AND H ORMONAL R EGULATION OF G ENE E XPRESSION
inferredcites →https://doi.org/10.1152/ajpendo.00478.2015openalex-snapshot
The glucocorticoid receptor: cause of or cure for obesity?
inferredcites →https://doi.org/10.1152/physiolgenomics.00030.2015openalex-snapshot
Muscle transcriptome response to ACTH administration in a free-ranging marine mammal
inferredcites →https://doi.org/10.1186/1471-2105-10-421openalex-snapshot
BLAST+: architecture and applications
inferredcites →https://doi.org/10.1186/1752-0509-1-24openalex-snapshot
Understanding network concepts in modules
inferredcites →https://doi.org/10.1186/gb-2009-10-3-r25openalex-snapshot
Ultrafast and memory-efficient alignment of short DNA sequences to the human genome
inferredcites →https://doi.org/10.1186/s12864-015-1253-6openalex-snapshot
Transcriptome analysis of northern elephant seal (Mirounga angustirostris) muscle tissue provides a novel molecular resource and physiological insights
inferredcites →https://doi.org/10.1186/s13059-014-0550-8openalex-snapshot
Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
inferredcites →https://doi.org/10.1194/jlr.r800085-jlr200openalex-snapshot
Regulation of fatty acid uptake into tissues: lipoprotein lipase- and CD36-mediated pathways
inferredcites →https://doi.org/10.1210/edrv.21.1.0389openalex-snapshot
How Do Glucocorticoids Influence Stress Responses? Integrating Permissive, Suppressive, Stimulatory, and Preparative Actions
inferredcites →https://doi.org/10.1210/en.2014-1374openalex-snapshot
Galectin-3 Activates PPARγ and Supports White Adipose Tissue Formation and High-Fat Diet-Induced Obesity
inferredcites →https://doi.org/10.1210/me.2004-0193openalex-snapshot
Learning New Tricks from Old Dogs: β-Adrenergic Receptors Teach New Lessons on Firing Up Adipose Tissue Metabolism
inferredcites →https://doi.org/10.1242/jeb.068833openalex-snapshot
Sex differences in fuel use and metabolism during development in fasting juvenile northern elephant seals
inferredcites →https://doi.org/10.1371/journal.pone.0038442openalex-snapshot
The Effects of Handling and Anesthetic Agents on the Stress Response and Carbohydrate Metabolism in Northern Elephant Seals
inferredcites →https://doi.org/10.1371/journal.pone.0116734openalex-snapshot
Brown Adipose Tissue in Cetacean Blubber
inferredcites →https://doi.org/10.3109/10799893.2014.948555openalex-snapshot
The NR4A orphan nuclear receptors: mediators in metabolism and diseases
inferredcites →https://doi.org/10.3389/fendo.2013.00164openalex-snapshot
A Non-Traditional Model of the Metabolic Syndrome: The Adaptive Significance of Insulin Resistance in Fasting-Adapted Seals
inferredcites →https://doi.org/10.3945/an.113.004663openalex-snapshot
Adiposity and Fat Metabolism in Lactating and Fasting Northern Elephant Seals
inferredcites →https://doi.org/10.48550/arxiv.1203.4802openalex-snapshot
A Reference-Free Algorithm for Computational Normalization of Shotgun Sequencing Data
inferredcites →https://doi.org/10.48550/arxiv.1505.02710openalex-snapshot
Near-optimal RNA-Seq quantification
inferredcites →https://doi.org/10.6084/m9.figshare.878460openalex-snapshot
khmer-protocols 0.8.3 documentation

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.1111/mms.12862zenodo-depositor-declared
Influence of sample location on blubber cortisol concentration in striped dolphins ( Stenella coeruleoalba ): The importance of the reference denominator
inferred← citeshttps://doi.org/10.1002/aqc.3105openalex-snapshot
Assessing cetacean body condition: Is total lipid content in blubber biopsies a useful monitoring tool?
inferred← citeshttps://doi.org/10.1002/ece3.6301openalex-snapshot
Evaluating cetacean body condition; a review of traditional approaches and new developments
inferred← citeshttps://doi.org/10.1007/978-3-031-77022-7_9openalex-snapshot
Physiological Effects of Sound on Marine Mammals
inferred← citeshttps://doi.org/10.1007/978-3-031-83015-0_4openalex-snapshot
Physiology
inferred← citeshttps://doi.org/10.1007/s00484-024-02672-yopenalex-snapshot
Functional transcriptome analysis revealed upregulation of MAPK-SMAD signalling pathways in chronic heat stress in crossbred cattle
inferred← citeshttps://doi.org/10.1016/b978-0-12-812144-3.00011-5openalex-snapshot
New Technologies for Monitoring Marine Mammal Health
inferred← citeshttps://doi.org/10.1016/b978-0-443-33122-0.00012-xopenalex-snapshot
Marine enzymes—Production, scale-up, and applications
inferred← citeshttps://doi.org/10.1016/j.cbd.2019.100644openalex-snapshot
Blubber proteome response to repeated ACTH administration in a wild marine mammal
inferred← citeshttps://doi.org/10.1016/j.cbpa.2024.111771openalex-snapshot
Physiological effects of research handling on the northern elephant seal (Mirounga angustirostris)
inferred← citeshttps://doi.org/10.1016/j.envpol.2019.03.083openalex-snapshot
Examining the relationships between blubber steroid hormones and persistent organic pollutants in common bottlenose dolphins
inferred← citeshttps://doi.org/10.1016/j.envres.2023.117839openalex-snapshot
Gene expression and trace elements in Greenlandic ringed seals (Pusa hispida)
inferred← citeshttps://doi.org/10.1016/j.jhazmat.2022.129939openalex-snapshot
Occurrences and potential lipid-disrupting effects of phthalate metabolites in humpback dolphins from the South China Sea
inferred← citeshttps://doi.org/10.1016/j.ocecoaman.2019.104860openalex-snapshot
The impact of marine vessels on the presence and behaviour of harbour porpoise (Phocoena phocoena) in the waters off Berry Head, Brixham (South West England)
inferred← citeshttps://doi.org/10.1021/acs.est.6c05765openalex-snapshot
Elephant Seal Blubber Under Multiple Stressors: Persistent Organic Pollutants, Stress Hormones and Hydrostatic Pressure Alter Transcriptome, Lipolysis and Leptin Secretion
inferred← citeshttps://doi.org/10.1038/s41598-017-06037-xopenalex-snapshot
Using blubber explants to investigate adipose function in grey seals: glycolytic, lipolytic and gene expression responses to glucose and hydrocortisone
inferred← citeshttps://doi.org/10.1038/s41598-017-09334-7openalex-snapshot
De novo transcriptome assembly for the spiny mouse (Acomys cahirinus)
inferred← citeshttps://doi.org/10.1038/s41598-019-39089-2openalex-snapshot
Blubber transcriptome responses to repeated ACTH administration in a marine mammal
inferred← citeshttps://doi.org/10.1093/bioadv/vbad114openalex-snapshot
DANGER analysis: risk-averse on/off-target assessment for CRISPR editing without a reference genome
inferred← citeshttps://doi.org/10.1093/conphys/coaa082openalex-snapshot
A blubber gene expression index for evaluating stress in marine mammals
inferred← citeshttps://doi.org/10.1093/conphys/coae059openalex-snapshot
Proteome profiling reveals opportunities to investigate biomarkers of oxidative stress and immune responses in blubber biopsies from free-ranging baleen whales
inferred← citeshttps://doi.org/10.1093/conphys/coy003openalex-snapshot
Not just fat: investigating the proteome of cetacean blubber tissue
inferred← citeshttps://doi.org/10.1093/conphys/coy040openalex-snapshot
Repeated adrenocorticotropic hormone administration alters adrenal and thyroid hormones in free-ranging elephant seals
inferred← citeshttps://doi.org/10.1093/conphys/coz018openalex-snapshot
Tracking transcriptomic responses to endogenous and exogenous variation in cetaceans in the Southern California Bight
inferred← citeshttps://doi.org/10.1093/icb/icaa065openalex-snapshot
Functional Studies with Primary Cells Provide a System for Genome-to-Phenome Investigations in Marine Mammals
inferred← citeshttps://doi.org/10.1093/icb/icaa083openalex-snapshot
Pinniped Ontogeny as a Window into the Comparative Physiology and Genomics of Hypoxia Tolerance
inferred← citeshttps://doi.org/10.1111/mec.17209openalex-snapshot
A novel RT‐qPCR health assay reveals differential expression of stress and immunoregulatory genes between the seasonal migrations of humpback whales (Megaptera novaeangliae)
inferred← citeshttps://doi.org/10.1111/mms.12517openalex-snapshot
Response to capture stress involves multiple corticosteroids and is associated with serum thyroid hormone concentrations in Guadalupe fur seals (Arctocephalus philippii townsendi)
inferred← citeshttps://doi.org/10.1111/mms.13148openalex-snapshot
Best practices for collecting and preserving marine mammal biological samples in the ‘omics era
inferred← citeshttps://doi.org/10.11144/javeriana.10554.34362openalex-snapshot
Herramientas genómicas aplicadas a la conservación de megafauna marina : aportes, retos y una mirada hacia su uso en Colombia
inferred← citeshttps://doi.org/10.1152/ajpregu.00165.2023openalex-snapshot
Effects of cortisol, epinephrine, and bisphenol contaminants on the transcriptional landscape of marine mammal blubber
inferred← citeshttps://doi.org/10.1152/ajpregu.00182.2019openalex-snapshot
Expression of obesity-related adipokine genes during fasting in a naturally obese marine mammal
inferred← citeshttps://doi.org/10.1152/ajpregu.00265.2025openalex-snapshot
Molecular shifts induced by pseudohypoxia in gray seal blubber: an ex vivo approach
inferred← citeshttps://doi.org/10.1152/physiolgenomics.00002.2018openalex-snapshot
Adipose transcriptome analysis provides novel insights into molecular regulation of prolonged fasting in northern elephant seal pups
inferred← citeshttps://doi.org/10.1186/s12864-019-5426-6openalex-snapshot
Sexual dimorphism in brain transcriptomes of Amami spiny rats (Tokudaia osimensis): a rodent species where males lack the Y chromosome
inferred← citeshttps://doi.org/10.1242/bio.036731openalex-snapshot
A sample preparation workflow for adipose tissue shotgun proteomics and proteogenomics
inferred← citeshttps://doi.org/10.1242/jeb.161471openalex-snapshot
Function and evolution of specialized endogenous lipids in toothed whales
inferred← citeshttps://doi.org/10.1242/jeb.178491openalex-snapshot
Intrinsic anti-inflammatory properties in the serum of two species of deep-diving seal
inferred← citeshttps://doi.org/10.1242/jeb.243198openalex-snapshot
Repeated stimulation of the HPA axis alters white blood cell count without increasing oxidative stress or inflammatory cytokines in fasting elephant seal pups
inferred← citeshttps://doi.org/10.1242/jeb.243572openalex-snapshot
Changes in apolipoprotein abundance dominate proteome responses to prolonged fasting in elephant seals
inferred← citeshttps://doi.org/10.1242/jeb.246694openalex-snapshot
Intracellular negative feedback mechanisms in blubber and muscle moderate acute stress responses in fasting seals
inferred← citeshttps://doi.org/10.31979/etd.qdnf-ch2xopenalex-snapshot
Research Handling Effects on Stress Hormones, Blood Parameters, and Heart Rate in Juvenile Northern Elephant Seals (Mirounga angustirostris)
inferred← citeshttps://doi.org/10.3389/fgene.2019.00643openalex-snapshot
Depletion of Hemoglobin Transcripts and Long-Read Sequencing Improves the Transcriptome Annotation of the Polar Bear (Ursus maritimus)
inferred← citeshttps://doi.org/10.3389/fmars.2023.1232305openalex-snapshot
Diving on damage—the muscle transcriptome of parasitic infested harbor porpoises (Phocoena phocoena) hints at oxidative stress but not hypoxia
inferred← citeshttps://doi.org/10.3389/fmars.2023.1290472openalex-snapshot
Cortisol and epinephrine alter the adipose functions and the mobilization of PCBs in adipose tissue slices from elephant seal
inferred← citeshttps://doi.org/10.3389/fmars.2024.1466968openalex-snapshot
Ex vivo and in vitro methods as a platform for studying anthropogenic effects on marine mammals: four challenges and how to meet them
inferred← citeshttps://doi.org/10.3389/fmars.2026.1753955openalex-snapshot
Blubber under stress: ex vivo cortisol exposure induces an anti-inflammatory state in precision-cut adipose tissue slices from humpback whales
inferred← citeshttps://doi.org/10.3389/fmars.2026.1818619openalex-snapshot
Comparison of gene expression in the skin tissue of gray, humpback, and fin whales
inferred← citeshttps://doi.org/10.3389/fphys.2020.615784openalex-snapshot
In vitro Lipolysis and Leptin Production of Elephant Seal Blubber Using Precision-Cut Adipose Tissue Slices
inferred← citeshttps://doi.org/10.3389/fphys.2022.1057721openalex-snapshot
Comprehensive molecular and morphological resolution of blubber stratification in a deep-diving, fasting-adapted seal
inferred← citeshttps://doi.org/10.3390/app152412937openalex-snapshot
Silent Disruptors: The Multifaceted Impact of Phthalates Across Aquatic Invertebrate and Vertebrate Taxa
inferred← citeshttps://doi.org/10.3390/life11040364openalex-snapshot
Multi-Omics Approaches and Radiation on Lipid Metabolism in Toothed Whales
inferred← citeshttps://doi.org/10.3390/su132413997openalex-snapshot
Transcriptomic Insight into the Melon Morphology of Toothed Whales for Aquatic Molecular Developments
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