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Clozapine modifies the differentiation program of human adipocytes inducing browning
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
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High content analysis of differentiation and cell death in human adipocytes
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inferredcites →https://doi.org/10.1038/sj.npp.1301209openalex-snapshot
Acute Effects of Atypical Antipsychotics on Whole-Body Insulin Resistance in Rats: Implications for Adverse Metabolic Effects
inferredcites →https://doi.org/10.1038/sj.npp.1301366openalex-snapshot
Atypical Antipsychotic Drugs Directly Impair Insulin Action in Adipocytes: Effects on Glucose Transport, Lipogenesis, and Antilipolysis
inferredcites →https://doi.org/10.1038/srep12540openalex-snapshot
Laser-scanning cytometry can quantify human adipocyte browning and proves effectiveness of irisin
inferredcites →https://doi.org/10.1038/tp.2013.83openalex-snapshot
Antipsychotics and the gut microbiome: olanzapine-induced metabolic dysfunction is attenuated by antibiotic administration in the rat
inferredcites →https://doi.org/10.1038/tp.2015.135openalex-snapshot
Use of the second-generation antipsychotic, risperidone, and secondary weight gain are associated with an altered gut microbiota in children
inferredcites →https://doi.org/10.1055/s-2004-815527openalex-snapshot
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inferredcites →https://doi.org/10.1055/s-2007-979318openalex-snapshot
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inferredcites →https://doi.org/10.1073/pnas.0611417104openalex-snapshot
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inferredcites →https://doi.org/10.1093/schbul/sbn104openalex-snapshot
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inferredcites →https://doi.org/10.1097/crd.0b013e31829cabffopenalex-snapshot
Brown Adipose Tissue Thermogenesis
inferredcites →https://doi.org/10.1111/j.1463-1326.2011.01378.xopenalex-snapshot
Adipocytes express a functional system for serotonin synthesis, reuptake and receptor activation
inferredcites →https://doi.org/10.1124/jpet.301.1.197openalex-snapshot
Differential Effects of Haloperidol and Clozapine on [3H]cAMP Binding, Protein Kinase A (PKA) Activity, and mRNA and Protein Expression of Selective Regulatory and Catalytic Subunit Isoforms of PKA in Rat Brain
inferredcites →https://doi.org/10.1128/mcb.00504-08openalex-snapshot
A Functional Interaction between RIP140 and PGC-1α Regulates the Expression of the Lipid Droplet Protein CIDEA
inferredcites →https://doi.org/10.1152/ajpendo.00105.2005openalex-snapshot
Indispensable role of mitochondrial UCP1 for antiobesity effect of β3-adrenergic stimulation
inferredcites →https://doi.org/10.1152/ajpendo.00202.2006openalex-snapshot
Identification of depot-specific human fat cell progenitors through distinct expression profiles and developmental gene patterns
inferredcites →https://doi.org/10.1152/physrev.00015.2003openalex-snapshot
Brown Adipose Tissue: Function and Physiological Significance
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inferredcites →https://doi.org/10.1172/jci67803openalex-snapshot
Recruited brown adipose tissue as an antiobesity agent in humans
inferredcites →https://doi.org/10.1176/ajp.155.1.48openalex-snapshot
Haloperidol Plasma Levels and Dose Optimization
inferredcites →https://doi.org/10.1177/0269881113515065openalex-snapshot
Clozapine effects on adenylyl cyclase activity and serotonin type 1A receptors in human brain post-mortem
inferredcites →https://doi.org/10.1177/0269881114555250openalex-snapshot
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inferredcites →https://doi.org/10.1210/er.2010-0030openalex-snapshot
Paracrine and Endocrine Effects of Adipose Tissue on Cancer Development and Progression
inferredcites →https://doi.org/10.1210/me.2010-0054openalex-snapshot
Regulation of Adipocyte Differentiation by Activation of Serotonin (5-HT) Receptors 5-HT2AR and 5-HT2CR and Involvement of MicroRNA-448-Mediated Repression of KLF5
inferredcites →https://doi.org/10.1242/jcs.108.10.3171openalex-snapshot
Functional assessment of white and brown adipocyte development and energy metabolism in cell culture Dissociation of terminal differentiation and thermogenesis in brown adipocytes
inferredcites →https://doi.org/10.1371/journal.pone.0157644openalex-snapshot
AMP-Activated Kinase (AMPK) Activation by AICAR in Human White Adipocytes Derived from Pericardial White Adipose Tissue Stem Cells Induces a Partial Beige-Like Phenotype
inferredcites →https://doi.org/10.1517/14740338.2012.691963openalex-snapshot
Thiazolidinedione safety
inferredcites →https://doi.org/10.1517/17460441.2013.821108openalex-snapshot
Novel approaches to drug design for the treatment of schizophrenia
inferredcites →https://doi.org/10.1523/jneurosci.23-15-06385.2003openalex-snapshot
Clozapine Reverses Hyperthermia and Sympathetically Mediated Cutaneous Vasoconstriction Induced by 3,4-Methylenedioxymethamphetamine (Ecstasy) in Rabbits and Rats
inferredcites →https://doi.org/10.15252/embr.201438775openalex-snapshot
Taking control over intracellular fatty acid levels is essential for the analysis of thermogenic function in cultured primary brown and brite/beige adipocytes
inferredcites →https://doi.org/10.2165/00023210-200519001-00001openalex-snapshot
Second-Generation (Atypical) Antipsychotics and Metabolic Effects
inferredcites →https://doi.org/10.2337/db09-0530openalex-snapshot
High Incidence of Metabolically Active Brown Adipose Tissue in Healthy Adult Humans
inferredcites →https://doi.org/10.2337/diabetes.54.3.862openalex-snapshot
Metabolic Dysregulation With Atypical Antipsychotics Occurs in the Absence of Underlying Disease A Placebo-Controlled Study of Olanzapine and Risperidone in Dogs
inferredcites →https://doi.org/10.33549/physiolres.930516openalex-snapshot
Clozapine blocks sympathetic and thermogenic reactions induced by orexin A in rat
inferredcites →https://doi.org/10.3389/fpsyt.2012.00062openalex-snapshot
Recent advances in understanding and mitigating adipogenic and metabolic effects of antipsychotic drugs
inferredcites →https://doi.org/10.3858/emm.2012.44.9.062openalex-snapshot
Inhibition of mouse brown adipocyte differentiation by second-generation antipsychotics
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
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Clozapine's Multiple Cellular Mechanisms: What Do We Know after More than Fifty Years? a Systematic Review and Critical Assessment of Translational Mechanisms Relevant for Innovative Strategies in Treatment-Resistant Schizophrenia
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ASC‐1 transporter‐dependent amino acid uptake is required for the efficient thermogenic response of human adipocytes to adrenergic stimulation
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Housing Temperature Influences Atypical Antipsychotic Drug‐Induced Bone Loss in Female C57BL / 6J Mice
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Antipsychotic Medications and DNA Methylation in Schizophrenia and Bipolar Disorder: A Systematic Review
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Schizophrenia, Curcumin and Minimizing Side Effects of Antipsychotic Drugs: Possible Mechanisms
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Cell-free ascites from ovarian cancer patients induces Warburg metabolism and cell proliferation through TGFβ-ERK signaling
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Adipocytes spectrum — From homeostasia to obesity and its associated pathology
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Olaparib induces browning of in vitro cultures of human primary white adipocytes
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inferred← citeshttps://doi.org/10.1016/j.jnutbio.2023.109385openalex-snapshot
Availability of abundant thiamine determines efficiency of thermogenic activation in human neck area derived adipocytes
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RGS2: A multifunctional signaling hub that balances brown adipose tissue function and differentiation
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Clozapine’s multiple cellular mechanisms: What do we know after more than fifty years? A systematic review and critical assessment of translational mechanisms relevant for innovative strategies in treatment-resistant schizophrenia
inferred← citeshttps://doi.org/10.1016/j.yexcr.2019.02.015openalex-snapshot
Interleukin-6 released from differentiating human beige adipocytes improves browning
inferred← citeshttps://doi.org/10.1017/ipm.2025.10117openalex-snapshot
Awareness of metabolic syndrome, lifestyle habits and attitudes towards physical health screening among service users prescribed clozapine
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Differentiating SGBS adipocytes respond to PPARγ stimulation, irisin and BMP7 by functional browning and beige characteristics
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Automated lipid droplet quantification system for phenotypic analysis of adipocytes using CellProfiler
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Atypical antipsychotics olanzapine and clozapine increase bone loss in female rats with experimental periodontitis
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Brown adipose tissue activity is modulated in olanzapine-treated young rats by simvastatin
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Antipsychotic-Induced Alterations in Lipid Turnover
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Curcumin Activates AMPK Pathway and Regulates Lipid Metabolism in Rats Following Prolonged Clozapine Exposure
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Potential links between brown adipose tissue, circadian dysregulation, and suicide risk
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Extracellular thiamine concentration influences thermogenic competency of differentiating neck area-derived human adipocytes
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A network analysis of gene co-expression in post-mortem brain tissues identifying novel genes and biological pathways underlying major depression
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Second-generation antipsychotic drugs and their impact on adipose tissue
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