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Natural products to drugs: natural product-derived compounds in clinical trials
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inferredcites →https://doi.org/10.1001/archneur.59.6.990openalex-snapshot
Intranasal Civamide for the Treatment of Episodic Cluster Headaches
inferredcites →https://doi.org/10.1001/archpsyc.63.6.630openalex-snapshot
Proof-of-Concept Trial of an α7 Nicotinic Agonist in Schizophrenia
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Intrathecal Ziconotide in the Treatment of Refractory Pain in Patients With Cancer or AIDS
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Antitumor compounds from tunicates
inferredcites →https://doi.org/10.1002/(sici)1521-3773(19990301)38:5<643::aid-anie643>3.0.co;2-gopenalex-snapshot
Statistical Investigation into the Structural Complementarity of Natural Products and Synthetic Compounds
inferredcites →https://doi.org/10.1002/1097-0142(20010915)92:6<1591::aid-cncr1485>3.0.co;2-uopenalex-snapshot
Homoharringtonine
inferredcites →https://doi.org/10.1002/anie.199417781openalex-snapshot
Isofagomine, a Potent, New Glycosidase Inhibitor
inferredcites →https://doi.org/10.1002/anie.199615671openalex-snapshot
Epothilone A and B—Novel 16‐Membered Macrolides with Cytotoxic Activity: Isolation, Crystal Structure, and Conformation in Solution
inferredcites →https://doi.org/10.1002/anie.199622881openalex-snapshot
Combinatorial Synthesis of Small Organic Molecules
inferredcites →https://doi.org/10.1002/anie.200200539openalex-snapshot
Application and Limitations of X‐ray Crystallographic Data in Structure‐Based Ligand and Drug Design
inferredcites →https://doi.org/10.1002/anie.200300581openalex-snapshot
NMR Spectroscopy Tools for Structure‐Aided Drug Design
inferredcites →https://doi.org/10.1002/anie.200300582openalex-snapshot
Chemistry and Biology of Roseophilin and the Prodigiosin Alkaloids: A Survey of the Last 2500 Years
inferredcites →https://doi.org/10.1002/anie.200352343openalex-snapshot
Highly Antimalaria‐Active Artemisinin Derivatives: Biological Activity Does Not Correlate with Chemical Reactivity
inferredcites →https://doi.org/10.1002/anie.200390115openalex-snapshot
Salinosporamide A: A Highly Cytotoxic Proteasome Inhibitor from a Novel Microbial Source, a Marine Bacterium of the New Genus Salinospora
inferredcites →https://doi.org/10.1002/anie.200503071openalex-snapshot
Artemisone—A Highly Active Antimalarial Drug of the Artemisinin Class
inferredcites →https://doi.org/10.1002/anie.200600350openalex-snapshot
Antibacterial Natural Products in Medicinal Chemistry—Exodus or Revival?
inferredcites →https://doi.org/10.1002/anie.200602785openalex-snapshot
Total Synthesis and Antitumor Activity of ZK‐EPO: The First Fully Synthetic Epothilone in Clinical Development
inferredcites →https://doi.org/10.1002/anie.200604997openalex-snapshot
Total Synthesis of the Potent Antitumor Macrolides Pladienolide B and D
inferredcites →https://doi.org/10.1002/anie.200790236openalex-snapshot
Total Synthesis of the Potent Antitumor Macrolides Pladienolide B and D
inferredcites →https://doi.org/10.1002/ardp.200700080openalex-snapshot
Rifalazil and Other Benzoxazinorifamycins in the Treatment of Chlamydia‐Based Persistent Infections
inferredcites →https://doi.org/10.1002/art.20424openalex-snapshot
The discovery and development of antiinflammatory drugs
inferredcites →https://doi.org/10.1002/bip.10296openalex-snapshot
Chemistry and biology of the ramoplanin family of peptide antibiotics
inferredcites →https://doi.org/10.1002/bit.10202openalex-snapshot
Optimizing the heterologous production of epothilone D in Myxococcus xanthus
inferredcites →https://doi.org/10.1002/bit.20279openalex-snapshot
Glucose metabolism in the antibiotic producing actinomycete Nonomuraea sp. ATCC 39727
inferredcites →https://doi.org/10.1002/cbdv.200790150openalex-snapshot
Cannabis, Pain, and Sleep: Lessons from Therapeutic Clinical Trials of Sativex®, a Cannabis‐Based Medicine
inferredcites →https://doi.org/10.1002/cbic.200390045openalex-snapshot
Chemical Chaperones—A New Concept in Drug Research
inferredcites →https://doi.org/10.1002/cbic.200700608openalex-snapshot
Rapid Identification of a Protein Binding Partner for the Marine Natural Product Kahalalide F by Using Reverse Chemical Proteomics
inferredcites →https://doi.org/10.1002/chin.200524271openalex-snapshot
Translation and Protein Synthesis: Macrolides
inferredcites →https://doi.org/10.1002/cncr.11791openalex-snapshot
Gemtuzumab ozogamicin in the treatment of acute myeloid leukemia
inferredcites →https://doi.org/10.1002/ejoc.200300580openalex-snapshot
Synthesis of the Trisaccharide and Tetrasaccharide Moieties of the Potent Immunoadjuvant QS‐21
inferredcites →https://doi.org/10.1002/em.10129openalex-snapshot
Genotoxicity and toxicity of the potential cancer‐preventive agent polyphenon E
inferredcites →https://doi.org/10.1002/hep.21587openalex-snapshot
Evaluation of a cyclophilin inhibitor in hepatitis C virus–infected chimeric mice in vivo†
inferredcites →https://doi.org/10.1002/ijc.10434openalex-snapshot
Novel camptothecin derivative BNP1350 in experimental human ovarian cancer: Determination of efficacy and possible mechanisms of resistance
inferredcites →https://doi.org/10.1002/ijc.11080openalex-snapshot
Marine pharmacology in 2000: Antitumor and cytotoxic compounds
inferredcites →https://doi.org/10.1002/ijc.20687openalex-snapshot
Novel inhibitors targeted to methionine aminopeptidase 2 (MetAP2) strongly inhibit the growth of cancers in xenografted nude model
inferredcites →https://doi.org/10.1002/jps.10134openalex-snapshot
Pharmacokinetics and Tissue Distribution of a New Partricin A Derivative (N-Dimethylaminoacetyl-Partricin A 2-Dimethylaminoethylamide Diaspartate) in Mice
inferredcites →https://doi.org/10.1002/jps.20835openalex-snapshot
A Mechanistic and Kinetic Study of the β-Lactone Hydrolysis of Salinosporamide A (NPI-0052), A Novel Proteasome Inhibitor
inferredcites →https://doi.org/10.1002/med.10003openalex-snapshot
Natural products as probes of cell biology: 20 years of didemnin research
inferredcites →https://doi.org/10.1002/med.10034openalex-snapshot
Recent progress in the development of coumarin derivatives as potent anti‐HIV agents
inferredcites →https://doi.org/10.1002/med.10042openalex-snapshot
Cholecystokinin antagonists: Pharmacological and therapeutic potential
inferredcites →https://doi.org/10.1002/med.20035openalex-snapshot
Morphine‐6‐glucuronide: Actions and mechanisms
inferredcites →https://doi.org/10.1002/med.20036openalex-snapshot
Development of ultra short‐acting muscle relaxant agents: History, research strategies, and challenges
inferredcites →https://doi.org/10.1002/med.20075openalex-snapshot
New developments in natural products‐based anti‐AIDS research
inferredcites →https://doi.org/10.1002/med.2610150103openalex-snapshot
Phenserine and ring C hetero‐analogues: Drug candidates for the treatment of Alzheimer's disease
inferredcites →https://doi.org/10.1002/pmic.200390046openalex-snapshot
Drug induced proteome changes in Candida albicans: Comparison of the effect of β(1,3) glucan synthase inhibitors and two triazoles, fluconazole and itraconazole
inferredcites →https://doi.org/10.1002/ppul.20736openalex-snapshot
A phase 2 study of aztreonam lysine for inhalation to treat patients with cystic fibrosis and Pseudomonas aeruginosa infection
inferredcites →https://doi.org/10.1002/rcm.1384openalex-snapshot
A sensitive method for the determination of the novel cholinesterase inhibitor ZT‐1 and its active metabolite huperzine A in rat blood using liquid chromatography/tandem mass spectrometry
inferredcites →https://doi.org/10.1002/rcm.1848openalex-snapshot
Development of a liquid chromatography/tandem mass spectrometry assay for the quantification of PM00104, a novel antineoplastic agent, in mouse, rat, dog, and human plasma
inferredcites →https://doi.org/10.1002/rcm.2644openalex-snapshot
Development of a liquid chromatography/tandem mass spectrometry assay for the quantification of PM02734, a novel antineoplastic agent, in dog plasma
inferredcites →https://doi.org/10.1002/rcm.2926openalex-snapshot
Elucidation of the in vitro metabolic profile of stable isotope labeled BAL19403 by accurate mass capillary liquid chromatography/quadrupole time‐of‐flight mass spectrometry and isotope exchange
inferredcites →https://doi.org/10.1002/rmv.534openalex-snapshot
Chemical genetics approach to hepatitis C virus replication: cyclophilin as a target for anti‐hepatitis C virus strategy
inferredcites →https://doi.org/10.1007/978-1-4899-0179-8_26openalex-snapshot
Heterocyclic Alkylphospholipids with an Improved Therapeutic Range
inferredcites →https://doi.org/10.1007/978-3-642-74560-7_6openalex-snapshot
Discovery and Development of Antineoplastic Agents from Natural Sources
inferredcites →https://doi.org/10.1007/bf00210783openalex-snapshot
Antitumor activity of combretastatin-A4 phosphate, a natural product tubulin inhibitor
inferredcites →https://doi.org/10.1007/bf00685608openalex-snapshot
Alkylphosphocholines: a new class of membrane-active anticancer agents
inferredcites →https://doi.org/10.1007/bf02113503openalex-snapshot
In vivo andin vitro antifungal activity of the polyene derivative SPA-S-753 against encapsulated form ofCryptococcus neoformans
inferredcites →https://doi.org/10.1007/bf02540789openalex-snapshot
The potential commercial aspects of gossypol
inferredcites →https://doi.org/10.1007/bf02854894openalex-snapshot
Drug discovery from natural sources
inferredcites →https://doi.org/10.1007/bf02975379openalex-snapshot
Antitumor activity of 7-[2-(N-isopropylamino)ethyl]-(20S)-camptothecin, CKD602, as a potent DNA topoisomerase I inhibitor
inferredcites →https://doi.org/10.1007/bf02979057openalex-snapshot
Effect of DA-6034, a derivative of flavonoid, on experimental animal models of inflammatory bowel disease
inferredcites →https://doi.org/10.1007/bf02980050openalex-snapshot
DA-125, a new antitumor agent, inhibits topoisomerase ii as topoisomerase poison and dna intercalator simultaneously
inferredcites →https://doi.org/10.1007/bf02980116openalex-snapshot
Absorption, distribution, metabolism, and excretion of CKD-732, a novel antiangiogenic fumagillin derivative, in rats, mice, and dogs
inferredcites →https://doi.org/10.1007/bfb0117491openalex-snapshot
Modulation of protein kinase C in antitumor treatment
inferredcites →https://doi.org/10.1007/s00125-003-1264-8openalex-snapshot
The vasopeptidase inhibitor AVE7688 ameliorates Type 2 diabetic nephropathy
inferredcites →https://doi.org/10.1007/s00125-005-1837-9openalex-snapshot
Renal accumulation and clearance of advanced glycation end-products in type 2 diabetic nephropathy: effect of angiotensin-converting enzyme and vasopeptidase inhibition
inferredcites →https://doi.org/10.1007/s00213-003-1750-1openalex-snapshot
Alpha-7 nicotinic receptor agonists: potential new candidates for the treatment of schizophrenia
inferredcites →https://doi.org/10.1007/s00221-003-1566-6openalex-snapshot
Treatment with the snail peptide CGX-1007 reduces DNA damage and alters gene expression of c-fos and bcl-2 following focal ischemic brain injury in rats
inferredcites →https://doi.org/10.1007/s00253-004-1626-2openalex-snapshot
Design of mineral medium for growth of Actinomadura sp. ATCC 39727, producer of the glycopeptide A40926: effects of calcium ions and nitrogen sources
inferredcites →https://doi.org/10.1007/s00280-002-0451-5openalex-snapshot
Synergistic effects of F 11782, a novel dual inhibitor of topoisomerases I and II, in combination with other anticancer agents
inferredcites →https://doi.org/10.1007/s00280-002-0566-8openalex-snapshot
Phase I and pharmacokinetic study of anhydrovinblastine every 3 weeks in patients with refractory solid tumors
inferredcites →https://doi.org/10.1007/s00280-003-0745-2openalex-snapshot
Broad-spectrum modulation of ATP-binding cassette transport proteins by the taxane derivatives ortataxel (IDN-5109, BAY 59-8862) and tRA96023
inferredcites →https://doi.org/10.1007/s00280-004-0765-6openalex-snapshot
Plasma and cerebrospinal fluid pharmacokinetic study of BNP1350 in nonhuman primates
inferredcites →https://doi.org/10.1007/s00280-005-0182-5openalex-snapshot
FK228 (depsipeptide): a HDAC inhibitor with pleiotropic antitumor activities
inferredcites →https://doi.org/10.1007/s00280-007-0430-yopenalex-snapshot
Preclinical pharmacokinetics and bioavailability of noscapine, a tubulin-binding anticancer agent
inferredcites →https://doi.org/10.1007/s00280-007-0486-8openalex-snapshot
A phase II open-label study of DHA-paclitaxel (Taxoprexin) by 2-h intravenous infusion in previously untreated patients with locally advanced or metastatic gastric or oesophageal adenocarcinoma
inferredcites →https://doi.org/10.1007/s00280-007-0489-5openalex-snapshot
A phase II study of milataxel: a novel taxane analogue in previously treated patients with advanced colorectal cancer
inferredcites →https://doi.org/10.1007/s00280-007-0544-2openalex-snapshot
Identification, characterization and potent antitumor activity of ECO-4601, a novel peripheral benzodiazepine receptor ligand
inferredcites →https://doi.org/10.1007/s00280-008-0720-zopenalex-snapshot
Antitumor activity of noscapine in human non-small cell lung cancer xenograft model
inferredcites →https://doi.org/10.1007/s002800100276openalex-snapshot
DA-125, a novel anthracycline derivative showing high-affinity DNA binding and topoisomerase II inhibitory activities, exerts cytotoxicity via c-Jun N-terminal kinase pathway
inferredcites →https://doi.org/10.1007/s00284-005-0027-9openalex-snapshot
A Comparison of a New Oral Streptogramin XRP 2868 with Quinupristin-Dalfopristin Against Antibiotic-Resistant Strains of Haemophilus influenzae, Staphylococcus aureus, and Streptococcus pneumoniae
inferredcites →https://doi.org/10.1007/s00405-002-0532-4openalex-snapshot
Comparison of the efficacy and safety of faropenem daloxate and cefuroxime axetil for the treatment of acute bacterial maxillary sinusitis in adults
inferredcites →https://doi.org/10.1007/s10126-002-0064-3openalex-snapshot
Sharks: A Potential Source of Antiangiogenic Factors and Tumor Treatments
inferredcites →https://doi.org/10.1007/s10156-004-0309-3openalex-snapshot
In vitro antimicrobial activity of T-91825, a novel anti-MRSA cephalosporin, and in vivo anti-MRSA activity of its prodrug, TAK-599
inferredcites →https://doi.org/10.1007/s10156-004-0348-9openalex-snapshot
Challenges and new discoveries in the treatment of leishmaniasis
inferredcites →https://doi.org/10.1007/s10295-006-0107-2openalex-snapshot
Drug discovery from natural products
inferredcites →https://doi.org/10.1007/s10295-006-0124-1openalex-snapshot
Understanding and manipulating glycopeptide pathways: the example of the dalbavancin precursor A40926
inferredcites →https://doi.org/10.1007/s10620-006-9657-4openalex-snapshot
Gastroprotective Effects of DA-6034, a New Flavonoid Derivative, in Various Gastric Mucosal Damage Models
inferredcites →https://doi.org/10.1007/s10637-006-9018-3openalex-snapshot
The 4′-O-benzylated doxorubicin analog WP744 overcomes resistance mediated by P-glycoprotein, multidrug resistance protein and breast cancer resistance protein in cell lines and acute myeloid leukemia cells
inferredcites →https://doi.org/10.1007/s11030-005-1542-0openalex-snapshot
Myxobacterial epothilones and tubulysins as promising anticancer agents
inferredcites →https://doi.org/10.1007/s11101-006-9010-8openalex-snapshot
Rutaceous alkaloids as models for the design of novel antitumor drugs
inferredcites →https://doi.org/10.1007/s11912-003-0095-6openalex-snapshot
Tubulin interacting agents: Novel taxanes and epothilones
inferredcites →https://doi.org/10.1016/0006-2952(92)90153-aopenalex-snapshot
Dolastatin 15, a potent antimitotic depsipeptide derived from Dolabella auricularia
inferredcites →https://doi.org/10.1016/0008-6215(95)00278-2openalex-snapshot
Structure of the saponin adjuvant QS-21 and its base-catalyzed isomerization product by 1H and natural abundance 13C NMR spectroscopy
inferredcites →https://doi.org/10.1016/0014-2999(94)90656-4openalex-snapshot
P2 purinoceptor antagonist properties of pyridoxal-5-phosphate
inferredcites →https://doi.org/10.1016/0014-5793(89)81546-7openalex-snapshot
Alkaloid homoharringtonine inhibits polypeptide chain elongation on human ribosomes on the step of peptide bond formation
inferredcites →https://doi.org/10.1016/0031-9422(81)85181-3openalex-snapshot
Castanospermine, A 1,6,7,8-tetrahydroxyoctahydroindolizine alkaloid, from seeds of Castanospermum australe
inferredcites →https://doi.org/10.1016/0039-128x(93)90040-topenalex-snapshot
Structure of the novel steroidal antibiotic squalamine determined by two-dimensional NMR spectroscopy
inferredcites →https://doi.org/10.1016/0040-4020(68)88115-3openalex-snapshot
Structure and synthesis of nojirimycin
inferredcites →https://doi.org/10.1016/0040-4020(93)80003-copenalex-snapshot
Isolation of dolastatins 10–15 from the marine mollusc
inferredcites →https://doi.org/10.1016/0040-4020(95)00646-popenalex-snapshot
Cytotoxic peptides from the marine sponge Cymbastela sp.
inferredcites →https://doi.org/10.1016/0041-0101(71)90040-7openalex-snapshot
A study of the occurrence of anabaseine in Paranemertes and other nemertines
inferredcites →https://doi.org/10.1016/1074-5521(94)90042-6openalex-snapshot
Distinct binding and cellular properties of synthetic (+)- and (-)-discodermolides
inferredcites →https://doi.org/10.1016/j.addr.2006.01.021openalex-snapshot
Zotarolimus (ABT-578) eluting stents
inferredcites →https://doi.org/10.1016/j.advenzreg.2005.02.017openalex-snapshot
The evolution of cancer research and drug discovery at Lilly Research Laboratories
inferredcites →https://doi.org/10.1016/j.amjcard.2007.08.021openalex-snapshot
Zotarolimus-Eluting Stents in Patients with Native Coronary Artery Disease: Clinical and Angiographic Outcomes in 1,317 Patients
inferredcites →https://doi.org/10.1016/j.bcp.2005.10.012openalex-snapshot
Natural products — The future scaffolds for novel antibiotics?
inferredcites →https://doi.org/10.1016/j.bcp.2005.12.005openalex-snapshot
Glycopeptides: Update on an old successful antibiotic class
inferredcites →https://doi.org/10.1016/j.bcp.2005.12.016openalex-snapshot
Empirical antibacterial drug discovery—Foundation in natural products
inferredcites →https://doi.org/10.1016/j.bcp.2006.10.023openalex-snapshot
Irofulven induces replication-dependent CHK2 activation related to p53 status
inferredcites →https://doi.org/10.1016/j.bcp.2006.12.015openalex-snapshot
Selective action of the iminosugar isofagomine, a pharmacological chaperone for mutant forms of acid-β-glucosidase
inferredcites →https://doi.org/10.1016/j.bcp.2007.07.015openalex-snapshot
Treating schizophrenia symptoms with an α7 nicotinic agonist, from mice to men
inferredcites →https://doi.org/10.1016/j.bcp.2007.08.016openalex-snapshot
Curcumin as “Curecumin”: From kitchen to clinic
inferredcites →https://doi.org/10.1016/j.bcp.2007.10.016openalex-snapshot
Next generation topoisomerase I inhibitors: Rationale and biomarker strategies
inferredcites →https://doi.org/10.1016/j.bcp.2007.11.019openalex-snapshot
Lobeline effects on tonic and methamphetamine-induced dopamine release
inferredcites →https://doi.org/10.1016/j.beem.2007.09.007openalex-snapshot
PKC inhibition and diabetic microvascular complications
inferredcites →https://doi.org/10.1016/j.bmc.2003.08.003openalex-snapshot
Semisynthetic modifications of hemiaminal function at ornithine unit of mulundocandin, towards chemical stability and antifungal activity
inferredcites →https://doi.org/10.1016/j.bmc.2003.11.012openalex-snapshot
Anti-HIV natural product (+)-calanolide A is active against both drug-susceptible and drug-resistant strains of Mycobacterium tuberculosis
inferredcites →https://doi.org/10.1016/j.bmc.2003.11.036openalex-snapshot
Camptothecin: current perspectives
inferredcites →https://doi.org/10.1016/j.bmc.2004.07.020openalex-snapshot
Synthesis, stereochemical determination and biochemical characterization of the enantiomeric phosphate esters of the novel immunosuppressive agent FTY720
inferredcites →https://doi.org/10.1016/j.bmc.2004.07.053openalex-snapshot
Synthesis and biological activities of novel 17-aminogeldanamycin derivatives
inferredcites →https://doi.org/10.1016/j.bmc.2004.10.008openalex-snapshot
Asymmetric synthesis and biological evaluation of the enantiomeric isomers of the immunosuppressive FTY720-phosphate
inferredcites →https://doi.org/10.1016/j.bmcl.2003.08.067openalex-snapshot
Semi-synthetic glycopeptide antibacterials
inferredcites →https://doi.org/10.1016/j.bmcl.2003.12.084openalex-snapshot
Approaches towards the stabilization of hemiaminal function at ornithine unit of mulundocandin
inferredcites →https://doi.org/10.1016/j.bmcl.2004.02.007openalex-snapshot
Epibatidine structure–activity relationships
inferredcites →https://doi.org/10.1016/j.bmcl.2004.08.068openalex-snapshot
Structurally simplified macrolactone analogues of halichondrin B
inferredcites →https://doi.org/10.1016/j.bmcl.2004.08.069openalex-snapshot
Macrocyclic ketone analogues of halichondrin B
inferredcites →https://doi.org/10.1016/j.bmcl.2007.04.061openalex-snapshot
Himbacine derived thrombin receptor antagonists: Discovery of a new tricyclic core
inferredcites →https://doi.org/10.1016/j.bmcl.2007.06.002openalex-snapshot
Himbacine derived thrombin receptor (PAR-1) antagonists: SAR of the pyridine ring
inferredcites →https://doi.org/10.1016/j.bmcl.2007.06.094openalex-snapshot
A synthetic entry to pladienolide B and FD-895
inferredcites →https://doi.org/10.1016/j.brainres.2004.04.041openalex-snapshot
Increased ATP content/production in the hypothalamus may be a signal for energy-sensing of satiety: studies of the anorectic mechanism of a plant steroidal glycoside
inferredcites →https://doi.org/10.1016/j.cbpa.2007.08.012openalex-snapshot
Natural products as a screening resource
inferredcites →https://doi.org/10.1016/j.cell.2007.03.004openalex-snapshot
Molecular Mechanisms of Antibacterial Multidrug Resistance
inferredcites →https://doi.org/10.1016/j.cell.2007.08.002openalex-snapshot
Crystal Structure of the TLR4-MD-2 Complex with Bound Endotoxin Antagonist Eritoran
inferredcites →https://doi.org/10.1016/j.chembiol.2003.09.002openalex-snapshot
The Process of Structure-Based Drug Design
inferredcites →https://doi.org/10.1016/j.chembiol.2004.04.020openalex-snapshot
Structural Transitions as Determinants of the Action of the Calcium-Dependent Antibiotic Daptomycin
inferredcites →https://doi.org/10.1016/j.chembiol.2004.09.012openalex-snapshot
Engineered Biosynthesis of Geldanamycin Analogs for Hsp90 Inhibition
inferredcites →https://doi.org/10.1016/j.chembiol.2007.03.005openalex-snapshot
Leapin' Lizards: Amylin Targets Diabetes and Obesity via Incretins
inferredcites →https://doi.org/10.1016/j.chemphyslip.2003.08.002openalex-snapshot
Synthesis and antiproliferative activity of alkylphosphocholines
inferredcites →https://doi.org/10.1016/j.chroma.2003.08.094openalex-snapshot
Development and validation of a liquid chromatography-ultraviolet absorbance detection assay using derivatisation for the novel marine anticancer agent ES-285·HCl [(2S,3R)-2-amino-3-octadecanol hydrochloride] and its pharmaceutical dosage form
inferredcites →https://doi.org/10.1016/j.copbio.2003.10.003openalex-snapshot
Antibacterials: are the new entries enough to deal with the emerging resistance problems?
inferredcites →https://doi.org/10.1016/j.coph.2004.04.006openalex-snapshot
Glycopeptides in clinical development: pharmacological profile and clinical perspectives
inferredcites →https://doi.org/10.1016/j.coph.2006.06.002openalex-snapshot
Anti-MRSA β-lactams in development
inferredcites →https://doi.org/10.1016/j.coph.2007.05.007openalex-snapshot
Clostridium difficile: new therapeutic options
inferredcites →https://doi.org/10.1016/j.ctrv.2004.04.006openalex-snapshot
Histone deacetylase inhibitors – a new tool to treat cancer
inferredcites →https://doi.org/10.1016/j.drudis.2007.04.009openalex-snapshot
New developments in synthetic peroxidic drugs as artemisinin mimics
inferredcites →https://doi.org/10.1016/j.drudis.2007.10.010openalex-snapshot
Plant-derived compounds in clinical trials
inferredcites →https://doi.org/10.1016/j.ejca.2004.09.005openalex-snapshot
Marine pharmacology in 2001–2: antitumour and cytotoxic compounds
inferredcites →https://doi.org/10.1016/j.ejca.2006.09.014openalex-snapshot
Brostallicin, an agent with potential activity in metastatic soft tissue sarcoma: A phase II study from the European Organisation for Research and Treatment of Cancer Soft Tissue and Bone Sarcoma Group
inferredcites →https://doi.org/10.1016/j.ejca.2007.11.019openalex-snapshot
Current perspectives of epothilones in breast cancer
inferredcites →https://doi.org/10.1016/j.ejmech.2004.05.001openalex-snapshot
Benzo[b]acronycine derivatives: a novel class of antitumor agents
inferredcites →https://doi.org/10.1016/j.ejpain.2007.07.009openalex-snapshot
Morphine‐6‐glucuronide (M6G) for postoperative pain relief
inferredcites →https://doi.org/10.1016/j.ejphar.2007.06.003openalex-snapshot
Lobelane decreases methamphetamine self-administration in rats
inferredcites →https://doi.org/10.1016/j.ejps.2006.04.006openalex-snapshot
Pharmacological properties of the ubiquitous natural product betulin
inferredcites →https://doi.org/10.1016/j.exppara.2006.09.016openalex-snapshot
In vitro and in vivo interaction of synthetic peroxide RBx11160 (OZ277) with piperaquine in Plasmodium models
inferredcites →https://doi.org/10.1016/j.jchromb.2005.10.027openalex-snapshot
Simultaneous determination of ZT-1 and its metabolite Huperzine A in plasma by high-performance liquid chromatography with ultraviolet detection
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Simultaneous determination of 1,5-dicaffeoylquinic acid and its active metabolites in human plasma by liquid chromatography–tandem mass spectrometry for pharmacokinetic studies
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Normal phase and reverse phase HPLC-UV-MS analysis of process impurities for rapamycin analog ABT-578: Application to active pharmaceutical ingredient process development
inferredcites →https://doi.org/10.1016/j.jep.2004.02.012openalex-snapshot
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Identification of a mutant human topoisomerase I with intact catalytic activity and resistance to 9-nitro-camptothecin.
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Gamma-carboxyglutamate in a neuroactive toxin.
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Binding of dolastatin 10 to tubulin at a distinct site for peptide antimitotic agents near the exchangeable nucleotide and vinca alkaloid sites.
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Inhibition of N-linked complex oligosaccharide formation by 1-deoxynojirimycin, an inhibitor of processing glucosidases.
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inferred← citeshttps://doi.org/10.1007/978-3-7091-0748-5_1openalex-snapshot
Chemistry and Biology of Rocaglamides (= Flavaglines) and Related Derivatives from Aglaia Species (Meliaceae)
inferred← citeshttps://doi.org/10.1007/978-3-7643-8117-2_1openalex-snapshot
Mother Nature’s gifts to diseases of man: the impact of natural products on anti-infective, anticholestemics and anticancer drug discovery
inferred← citeshttps://doi.org/10.1007/978-3-7643-8117-2_2openalex-snapshot
Drug discovery and development with plant-derived compounds
inferred← citeshttps://doi.org/10.1007/978-3-7643-8595-8_7openalex-snapshot
Histone deacetylase inhibitors from microorganisms: the Astellas experience
inferred← citeshttps://doi.org/10.1007/978-81-322-1575-2_10openalex-snapshot
Endophytes as a Novel Source of Bioactive New Structures
inferred← citeshttps://doi.org/10.1007/978-81-322-2782-3_5openalex-snapshot
Plant-Derived Antifungal Agents: Past and Recent Developments
inferred← citeshttps://doi.org/10.1007/978-90-481-3834-0_18openalex-snapshot
Biosynthetic Principles in Marine Natural Product Systems
inferred← citeshttps://doi.org/10.1007/978-94-007-5237-5_18openalex-snapshot
Herbal Cognitive Enhancers: New Developments and Challenges for Therapeutic Applications
inferred← citeshttps://doi.org/10.1007/978-981-10-5978-0_16openalex-snapshot
Identification Strategies for Bioactive Secondary Metabolites of Fungal Origin
inferred← citeshttps://doi.org/10.1007/978-981-10-8064-7_6openalex-snapshot
Medicinal Plants as a Potential Source of Chemopreventive Agents
inferred← citeshttps://doi.org/10.1007/978-981-13-6920-9_2openalex-snapshot
Synthetic Analogs of Phytochemicals
inferred← citeshttps://doi.org/10.1007/978-981-13-7466-1_14openalex-snapshot
Recent Patents on Endophytic Fungi and Their International Market
inferred← citeshttps://doi.org/10.1007/978-981-13-7607-8_1openalex-snapshot
Anticancer Alkaloids: Molecular Mechanisms and Clinical Manifestations
inferred← citeshttps://doi.org/10.1007/978-981-13-9073-9_22openalex-snapshot
Antivirals: Past, Present and Future
inferred← citeshttps://doi.org/10.1007/978-981-13-9566-6_5openalex-snapshot
Medicinal Plants as a Source of Alkaloids
inferred← citeshttps://doi.org/10.1007/978-981-19-0832-3_1openalex-snapshot
Pyridines, Dihydropyridines and Piperidines: An Outline on Synthesis and Biological Activities
inferred← citeshttps://doi.org/10.1007/978-981-19-3979-2_12openalex-snapshot
Use of Engineered Bacteria for the Production of Green Chemical and Pharmaceuticals
inferred← citeshttps://doi.org/10.1007/978-981-97-1777-4_10openalex-snapshot
Translational Research in Microbial Healthcare Products with Special Reference to Anticancer Drug Discovery from Actinobacteria
inferred← citeshttps://doi.org/10.1007/978-981-97-4600-2_13openalex-snapshot
The Importance of Natural Products in Drug Discovery: Opportunities and Success
inferred← citeshttps://doi.org/10.1007/978-981-97-4600-2_4openalex-snapshot
Importance of Traditional Knowledge in Modern Drug Discovery
inferred← citeshttps://doi.org/10.1007/978-981-99-7703-1_17openalex-snapshot
Herbal Medicines for the Management of Diseases on Vitamin Deficiency
inferred← citeshttps://doi.org/10.1007/bf02854894openalex-snapshot
Drug discovery from natural sources
inferred← citeshttps://doi.org/10.1007/s00044-014-0940-1openalex-snapshot
Indolizine: a biologically active moiety
inferred← citeshttps://doi.org/10.1007/s00044-014-1023-zopenalex-snapshot
RETRACTED ARTICLE: Functionalized benzyls as selective κ-OR agonists
inferred← citeshttps://doi.org/10.1007/s00044-014-1280-xopenalex-snapshot
Molecular modeling of plant metabolites with anti-Onchocerca activity
inferred← citeshttps://doi.org/10.1007/s00044-018-2268-8openalex-snapshot
Mechanistic studies of the apoptosis induced by the macrocyclic natural product tetrandrine in MGC 803 cells
inferred← citeshttps://doi.org/10.1007/s00044-018-2281-yopenalex-snapshot
Isolation, structural modification of macrophin from endophytic fungus Phoma macrostoma and their cytotoxic potential
inferred← citeshttps://doi.org/10.1007/s00044-021-02835-1openalex-snapshot
Semi-synthesis and cytotoxicity evaluation of pyrimidine, thiazole, and indole analogues of argentatins A–C from guayule (Parthenium argentatum) resin
inferred← citeshttps://doi.org/10.1007/s00203-019-01634-yopenalex-snapshot
Isolation, characterization, and structural elucidation of 4-methoxyacetanilide from marine actinobacteria Streptomyces sp. SCA29 and evaluation of its enzyme inhibitory, antibacterial, and cytotoxic potential
inferred← citeshttps://doi.org/10.1007/s00253-021-11228-8openalex-snapshot
Joint engineering of SACE_Lrp and its target MarR enhances the biosynthesis and export of erythromycin in Saccharopolyspora erythraea
inferred← citeshttps://doi.org/10.1007/s00253-022-12046-2openalex-snapshot
Indispensable role of microbes in anticancer drugs and discovery trends
inferred← citeshttps://doi.org/10.1007/s00253-022-12153-0openalex-snapshot
Crosstalk of TetR-like regulator SACE_4839 and a nitrogen regulator for erythromycin biosynthesis
inferred← citeshttps://doi.org/10.1007/s00344-020-10129-wopenalex-snapshot
Extracellular DNA: A Relevant Plant Damage-Associated Molecular Pattern (DAMP) for Crop Protection Against Pests—A Review
inferred← citeshttps://doi.org/10.1007/s00436-015-4708-4openalex-snapshot
Antileishmanial activity and evaluation of the mechanism of action of strychnobiflavone flavonoid isolated from Strychnos pseudoquina against Leishmania infantum
inferred← citeshttps://doi.org/10.1007/s00723-015-0644-9openalex-snapshot
Influence of Substituents on the Lappaconitine Acetylenic Derivatives Photodegradation
inferred← citeshttps://doi.org/10.1007/s00726-022-03159-zopenalex-snapshot
Structural diversity using amino acid “Customizable Units”: conversion of hydroxyproline (Hyp) into nitrogen heterocycles
inferred← citeshttps://doi.org/10.1007/s00894-011-1135-zopenalex-snapshot
In silico screening of epidermal growth factor receptor (EGFR) in the tyrosine kinase domain through a medicinal plant compound database
inferred← citeshttps://doi.org/10.1007/s10126-009-9235-9openalex-snapshot
Culture of Explants from the Sponge Mycale cecilia to Obtain Bioactive Mycalazal-Type Metabolites
inferred← citeshttps://doi.org/10.1007/s10295-006-0092-5openalex-snapshot
Engineering biosynthetic pathways to generate antitumor indolocarbazole derivatives
inferred← citeshttps://doi.org/10.1007/s10295-006-0107-2openalex-snapshot
Drug discovery from natural products
inferred← citeshttps://doi.org/10.1007/s10295-011-0970-3openalex-snapshot
Engineering microbial factories for synthesis of value-added products
inferred← citeshttps://doi.org/10.1007/s10295-015-1706-6openalex-snapshot
Culture-independent discovery of natural products from soil metagenomes
inferred← citeshttps://doi.org/10.1007/s10295-019-02178-2openalex-snapshot
Characterization and engineering of the Lrp/AsnC family regulator SACE_5717 for erythromycin overproduction in Saccharopolyspora erythraea
inferred← citeshttps://doi.org/10.1007/s10529-012-1056-7openalex-snapshot
Genetic manipulation revealing an unusual N-terminal region in a stand-alone non-ribosomal peptide synthetase involved in the biosynthesis of ramoplanins
inferred← citeshttps://doi.org/10.1007/s10529-014-1498-1openalex-snapshot
Bioreactors for plant cells: hardware configuration and internal environment optimization as tools for wider commercialization
inferred← citeshttps://doi.org/10.1007/s10616-017-0153-9openalex-snapshot
Oxymatrine induces apoptosis and inhibits invasion in Gallbladder carcinoma via PTEN/PI3K/AKT pathway
inferred← citeshttps://doi.org/10.1007/s10787-017-0350-3openalex-snapshot
Triterpenoids principle of Wedelia calendulacea attenuated diethynitrosamine-induced hepatocellular carcinoma via down-regulating oxidative stress, inflammation and pathology via NF-kB pathway
inferred← citeshttps://doi.org/10.1007/s10876-017-1180-6openalex-snapshot
Ag Nanoparticles Synthesized Using β-Caryophyllene Isolated from Murraya koenigii: Antimalarial (Plasmodium falciparum 3D7) and Anticancer Activity (A549 and HeLa Cell Lines)
inferred← citeshttps://doi.org/10.1007/s11010-017-3195-6openalex-snapshot
Mode of treatment governs curcumin response on doxorubicin-induced toxicity in cardiomyoblasts
inferred← citeshttps://doi.org/10.1007/s11030-010-9262-5openalex-snapshot
Natural products as DNA methyltransferase inhibitors: a computer-aided discovery approach
inferred← citeshttps://doi.org/10.1007/s11030-012-9417-7openalex-snapshot
High-throughput virtual screening of phloroglucinol derivatives against HIV-reverse transcriptase
inferred← citeshttps://doi.org/10.1007/s11030-024-10920-xopenalex-snapshot
Discovery of a novel pyrido[1,2-a]thiazolo[5,4-d]pyrimidinone derivatives with excellent potency against acetylcholinesterase
inferred← citeshttps://doi.org/10.1007/s11030-024-10994-7openalex-snapshot
Larvicidal activity, molecular docking, and molecular dynamics studies of 7-(trifluoromethyl)indolizine derivatives against Anopheles arabiensis
inferred← citeshttps://doi.org/10.1007/s11033-018-4193-9openalex-snapshot
Anti-inflammatory activity of dimethyl octenol and oleanene tetrol isolated from Trianthema decandra L.
inferred← citeshttps://doi.org/10.1007/s11033-021-06985-8openalex-snapshot
The protective effect of carvacrol on acetaminophen-induced renal damage in male rats
inferred← citeshttps://doi.org/10.1007/s11064-013-1119-8openalex-snapshot
The Fruits of Maclura pomifera Extracts Inhibits Glioma Stem-Like Cell Growth and Invasion
inferred← citeshttps://doi.org/10.1007/s11094-010-0348-2openalex-snapshot
Prospects for the creation of new antiviral drugs based on glycyrrhizic acid and its derivatives (a review)
inferred← citeshttps://doi.org/10.1007/s11101-010-9198-5openalex-snapshot
Fungal metabolites: structural diversity as incentive for anticancer drug development
inferred← citeshttps://doi.org/10.1007/s11101-014-9360-6openalex-snapshot
Natural products and their derivatives as inhibitors of glycogen phosphorylase: potential treatment for type 2 diabetes
inferred← citeshttps://doi.org/10.1007/s11101-014-9367-zopenalex-snapshot
The pharmaceutical industry and natural products: historical status and new trends
inferred← citeshttps://doi.org/10.1007/s11101-014-9386-9openalex-snapshot
New perspectives on the use of nucleic acids in pharmacological applications: inhibitory action of extracellular self-DNA in biological systems
inferred← citeshttps://doi.org/10.1007/s11101-015-9449-6openalex-snapshot
A review of the ethnomedicinal uses, phytochemistry and pharmacology of the Pleiocarpa genus
inferred← citeshttps://doi.org/10.1007/s11101-019-09606-2openalex-snapshot
The landscape of natural product diversity and their pharmacological relevance from a focus on the Dictionary of Natural Products®
inferred← citeshttps://doi.org/10.1007/s11130-009-0133-0openalex-snapshot
Antioxidant and Antiproliferative Activity of Diospyros lotus L. Extract and Isolated Compounds
inferred← citeshttps://doi.org/10.1007/s11172-011-0369-3openalex-snapshot
1,3-Cycloaddition synthesis of 1,2,3-triazole conjugates of betulonic acid with peptides
inferred← citeshttps://doi.org/10.1007/s11192-015-1715-2openalex-snapshot
Trends in the chemical and pharmacological research on the tropical trees Calophyllum brasiliense and Calophyllum inophyllum, a global context
inferred← citeshttps://doi.org/10.1007/s11274-023-03522-6openalex-snapshot
An overview on the two-component systems of Streptomyces coelicolor
inferred← citeshttps://doi.org/10.1007/s11427-020-1959-5openalex-snapshot
Natural products for infectious microbes and diseases: an overview of sources, compounds, and chemical diversities
inferred← citeshttps://doi.org/10.1007/s11626-014-9807-5openalex-snapshot
Evaluation of wild yam (Dioscorea villosa) root extract as a potential epigenetic agent in breast cancer cells
inferred← citeshttps://doi.org/10.1007/s11626-017-0222-6openalex-snapshot
Anti-hypotensive drug induced cardiotoxicity: an in vitro study
inferred← citeshttps://doi.org/10.1007/s11694-015-9253-4openalex-snapshot
Evaluation of in vitro antioxidant and brine shrimp lethality activities of different stem extracts of Zizyphus rugosa Lam
inferred← citeshttps://doi.org/10.1007/s11696-026-05188-4openalex-snapshot
Design, synthesis, and in vitro anticancer and anti-influenza evaluation of 2-amino-3-benzoyl-N-indolizine-1-carboxamide derivatives
inferred← citeshttps://doi.org/10.1007/s12010-015-1538-xopenalex-snapshot
Characterization of a Potential β-Lactamase Inhibitory Metabolite from a Marine Streptomyces sp. PM49 Active Against Multidrug-Resistant Pathogens
inferred← citeshttps://doi.org/10.1007/s12032-009-9286-9openalex-snapshot
Growth inhibition and cell-cycle arrest of human gastric cancer cells by Lycium barbarum polysaccharide
inferred← citeshttps://doi.org/10.1007/s12032-009-9415-5openalex-snapshot
Anticancer effect of Lycium barbarum polysaccharides on colon cancer cells involves G0/G1 phase arrest
inferred← citeshttps://doi.org/10.1007/s12032-022-01791-zopenalex-snapshot
Addressing artifacts of colorimetric anticancer assays for plant-based drug development
inferred← citeshttps://doi.org/10.1007/s12094-007-0138-9openalex-snapshot
Natural products as leads to anticancer drugs
inferred← citeshttps://doi.org/10.1007/s12223-020-00783-8openalex-snapshot
Chlorinated plastoquinone analogs that inhibit Staphylococcus epidermidis and Candida albicans growth
inferred← citeshttps://doi.org/10.1007/s12223-021-00860-6openalex-snapshot
Antibacterial activity of selected invertebrate species
inferred← citeshttps://doi.org/10.1007/s12257-018-0384-4openalex-snapshot
Prescreening of Natural Products in Drug Discovery Using Recombinant Bioluminescent Bacteria
inferred← citeshttps://doi.org/10.1007/s12272-013-0207-2openalex-snapshot
Antioxidant and anticancer activity of 3,5-dihydroxy-4-isopropylstilbene produced by Bacillus sp. N strain isolated from entomopathogenic nematode
inferred← citeshttps://doi.org/10.1007/s12539-013-0200-yopenalex-snapshot
In silico molecular docking, preclinical evaluation of spiroindimicins A-D, lynamicin A and D isolated from deep marine sea derived Streptomyces sp. SCSIO 03032
inferred← citeshttps://doi.org/10.1007/s13205-016-0586-4openalex-snapshot
Microbial metabolites in nutrition, healthcare and agriculture
inferred← citeshttps://doi.org/10.1007/s13205-024-03925-8openalex-snapshot
Natural flavonoids as potential therapeutics in the management of Alzheimer’s disease: a review
inferred← citeshttps://doi.org/10.1007/s13346-023-01366-zopenalex-snapshot
Lipid-based nanoparticle-mediated combination therapy for breast cancer management: a comprehensive review
inferred← citeshttps://doi.org/10.1007/s13659-014-0038-yopenalex-snapshot
Endophytes as Producers of Peptides: An Overview About the Recently Discovered Peptides from Endophytic Microbes
inferred← citeshttps://doi.org/10.1007/s40011-015-0619-5openalex-snapshot
Antibacterial Activity of Streptomyces sp. VITMK1 Isolated from Mangrove Soil of Pichavaram, Tamil Nadu, India
inferred← citeshttps://doi.org/10.1007/s40199-021-00401-zopenalex-snapshot
Putative role of natural products as Protein Kinase C modulator in different disease conditions
inferred← citeshttps://doi.org/10.1007/s40203-021-00115-9openalex-snapshot
Structure based virtual screening of natural product molecules as glycosidase inhibitors
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