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Plant-derived triterpenoids and analogues as antitumor and anti-HIV agents
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1002/cbdv.200890051openalex-snapshotBioactive Constituents of Myrrh and Frankincense, Two Simultaneously Prescribed Gum Resins in Chinese Traditional Medicine
inferredcites →https://doi.org/10.1002/ijc.21478openalex-snapshotSignalling responses linked to betulinic acid‐induced apoptosis are antagonized by MEK inhibitor U0126 in adherent or 3D spheroid melanoma irrespective of p53 status
inferredcites →https://doi.org/10.1002/ijc.22174openalex-snapshotAnticancer effects of amooranin in human colon carcinoma cell line in vitro and in nude mice xenografts
inferredcites →https://doi.org/10.1002/mc.20442openalex-snapshotRetracted: Prasad, S., Nigam, N., Kalra, N. and Shukla, Y. (2008), Regulation of signaling pathways involved in lupeol induced inhibition of proliferation and induction of apoptosis in human prostate cancer cells. Mol. Carcinog., 47: 916‐924. https://doi.org/10.1002/mc.20442
inferredcites →https://doi.org/10.1002/mc.20447openalex-snapshotBetulinic acid suppresses constitutive and TNFα‐induced NF‐κB activation and induces apoptosis in human prostate carcinoma PC‐3 cells
inferredcites →https://doi.org/10.1002/med.10053openalex-snapshotChemistry, biological activity, and chemotherapeutic potential of betulinic acid for the prevention and treatment of cancer and HIV infection
inferredcites →https://doi.org/10.1002/ptr.2058openalex-snapshotAntiproliferative effect on human cancer cell lines after treatment with nimbolide extracted from an edible part of the neem tree ( Azadirachta indica )
inferredcites →https://doi.org/10.1002/ptr.2159openalex-snapshotGedunin, a limonoid from Xylocarpus granatum, inhibits the growth of CaCo‐2 colon cancer cell line In Vitro
inferredcites →https://doi.org/10.1007/s00432-007-0255-4openalex-snapshotUrsolic acid inhibits the formation of aberrant crypt foci and affects colonic sphingomyelin hydrolyzing enzymes in azoxymethane-treated rats
inferredcites →https://doi.org/10.1016/j.bmc.2007.03.002openalex-snapshotSelective inhibition of the interaction of C1q with immunoglobulins and the classical pathway of complement activation by steroids and triterpenoids sulfates
inferredcites →https://doi.org/10.1016/j.bmc.2007.06.033openalex-snapshotSynthesis and structure–activity relationship study of cytotoxic germanicane- and lupane-type 3β-O-monodesmosidic saponins starting from betulin
inferredcites →https://doi.org/10.1016/j.bmcl.2007.09.081openalex-snapshotAnti-AIDS agents 73: Structure–activity relationship study and asymmetric synthesis of 3-O-monomethylsuccinyl-betulinic acid derivatives
inferredcites →https://doi.org/10.1016/j.bmcl.2008.03.031openalex-snapshotStructure-dependent inhibition of bladder and pancreatic cancer cell growth by 2-substituted glycyrrhetinic and ursolic acid derivatives
inferredcites →https://doi.org/10.1016/j.canlet.2007.11.039openalex-snapshotInduction of apoptosis accompanying with G1 phase arrest and microtubule disassembly in human hepatoma cells by jaspolide B, a new isomalabaricane-type triterpene
inferredcites →https://doi.org/10.1016/j.ejphar.2008.06.104openalex-snapshotA quassinoid 6α-tigloyloxychaparrinone inhibits hypoxia-inducible factor-1 pathway by inhibition of eukaryotic translation initiation factor 4E phosphorylation
inferredcites →https://doi.org/10.1016/j.lfs.2005.05.066openalex-snapshotDehydrotrametenolic acid selectively inhibits the growth of H-ras transformed rat2 cells and induces apoptosis through caspase-3 pathway
inferredcites →https://doi.org/10.1016/j.tet.2006.03.034openalex-snapshotNovel 24-nor-, 24-nor-2,3-seco-, and 3,24-dinor-2,4-seco-ursane triterpenes from Diospyros decandra: evidences for ring A biosynthetic transformations
inferredcites →https://doi.org/10.1016/j.toxlet.2008.01.008openalex-snapshotComparison of the irritation potentials of Boswellia serrata gum resin and of acetyl-11-keto-β-boswellic acid by in vitro cytotoxicity tests on human skin-derived cell lines
inferredcites →https://doi.org/10.1016/s0960-894x(02)00105-1openalex-snapshotA novel dicyanotriterpenoid, 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-onitrile, active at picomolar concentrations for inhibition of nitric oxide production
inferredcites →https://doi.org/10.1016/s0960-894x(98)00479-xopenalex-snapshotDesign and synthesis of 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid, a novel and highly active inhibitor of nitric oxide production in mouse macrophages
inferredcites →https://doi.org/10.1017/s0007114508882979openalex-snapshotAntiproliferative and apoptosis-inducing effects of maslinic and oleanolic acids, two pentacyclic triterpenes from olives, on HT-29 colon cancer cells
inferredcites →https://doi.org/10.1021/jf052812qopenalex-snapshotAntiproliferative Terpenoids from Almond Hulls (Prunus dulcis): Identification and Structure−Activity Relationships
inferredcites →https://doi.org/10.1021/jf063563oopenalex-snapshotTriterpenoids Isolated from Apple Peels Have Potent Antiproliferative Activity and May Be Partially Responsible for Apple's Anticancer Activity
inferredcites →https://doi.org/10.1021/jm020069copenalex-snapshotAnti-AIDS Agents 49. Synthesis, Anti-HIV, and Anti-Fusion Activities of IC9564 Analogues Based on Betulinic Acid
inferredcites →https://doi.org/10.1021/jm070295sopenalex-snapshotSpecific Plant Terpenoids and Lignoids Possess Potent Antiviral Activities against Severe Acute Respiratory Syndrome Coronavirus
inferredcites →https://doi.org/10.1021/jm8007486openalex-snapshotGedunin, a Novel Hsp90 Inhibitor: Semisynthesis of Derivatives and Preliminary Structure−Activity Relationships
inferredcites →https://doi.org/10.1021/jm950669uopenalex-snapshotBetulinic Acid Derivatives: A New Class of Specific Inhibitors of Human Immunodeficiency Virus Type 1 Entry
inferredcites →https://doi.org/10.1021/np010211xopenalex-snapshotAnti-AIDS Agents. 48. Anti-HIV Activity of Moronic Acid Derivatives and the New Melliferone-Related Triterpenoid Isolated from Brazilian Propolis
inferredcites →https://doi.org/10.1021/np058083qopenalex-snapshotCytotoxic Constituents from the Stem Bark of Dichapetalum gelonioides Collected in the Philippines,1
inferredcites →https://doi.org/10.1021/np060278qopenalex-snapshotSodwanone and Yardenone Triterpenes from a South African Species of the Marine Sponge Axinella Inhibit Hypoxia-Inducible Factor-1 (HIF-1) Activation in Both Breast and Prostate Tumor Cells
inferredcites →https://doi.org/10.1021/np060631sopenalex-snapshotTriterpenoids from the Floral Spikes of Betula platyphylla var. japonica and Their Reversing Activity against Multidrug-Resistant Cancer Cells
inferredcites →https://doi.org/10.1021/np0704396openalex-snapshotOctanorcucurbitane and Cucurbitane Triterpenoids from the Tubers of Hemsleya endecaphylla with HIV-1 Inhibitory Activity
inferredcites →https://doi.org/10.1021/np070613qopenalex-snapshotAntitumor Agents. 261. 20(S)-Protopanaxadiol and 20(S)-Protopanaxatriol as Antiangiogenic Agents and Total Assignment of 1H NMR Spectra
inferredcites →https://doi.org/10.1021/np50104a008openalex-snapshotAnti-AIDS Agents, 11. Betulinic Acid and Platanic Acid as Anti-HIV Principles from Syzigium claviflorum, and the Anti-HIV Activity of Structurally Related Triterpenoids
inferredcites →https://doi.org/10.1021/np800093aopenalex-snapshotLupane-Type Triterpenoids from Microtropis fokienensis and Perrottetia arisanensis and the Apoptotic Effect of 28-Hydroxy-3-oxo-lup-20(29)-en-30-al
inferredcites →https://doi.org/10.1021/np8001139openalex-snapshotAnti-HIV-1 Protease Activity of Lanostane Triterpenes from the Vietnamese Mushroom Ganoderma colossum
inferredcites →https://doi.org/10.1021/np9800710openalex-snapshotAnti-AIDS Agents. 30. Anti-HIV Activity of Oleanolic Acid, Pomolic Acid, and Structurally Related Triterpenoids
inferredcites →https://doi.org/10.1021/ol0473187openalex-snapshotLancifodilactone F: A Novel Nortriterpenoid Possessing a Unique Skeleton from Schisandra lancifolia and Its Anti-HIV Activity
inferredcites →https://doi.org/10.1021/ol050502nopenalex-snapshotLancifodilactone G: A Unique Nortriterpenoid Isolated from Schisandra lancifolia and Its Anti-HIV Activity
inferredcites →https://doi.org/10.1021/ol060062fopenalex-snapshotRubriflordilactones A and B, Two Novel Bisnortriterpenoids from Schisandra rubriflora and Their Biological Activities
inferredcites →https://doi.org/10.1021/ol701679nopenalex-snapshotStructural Characterization of Schintrilactone, a New Class of Nortriterpenoids from Schisandra chinensis
inferredcites →https://doi.org/10.1038/nm1095-1046openalex-snapshotDiscovery of betulinic acid as a selective inhibitor of human melanoma that functions by induction of apoptosis
inferredcites →https://doi.org/10.1038/nrc2129openalex-snapshotTriterpenoids and rexinoids as multifunctional agents for the prevention and treatment of cancer
inferredcites →https://doi.org/10.1038/sj.bjc.6604227openalex-snapshot20(S)-25-methoxyl-dammarane-3β, 12β, 20-triol, a novel natural product for prostate cancer therapy: activity in vitro and in vivo and mechanisms of action
inferredcites →https://doi.org/10.1039/b501932jopenalex-snapshotStructure and anti-HIV activity of micrandilactones B and C, new nortriterpenoids possessing a unique skeleton from Schisandra micrantha
inferredcites →https://doi.org/10.1055/s-2006-951680openalex-snapshotCharacterization of 3α-Acetyl-11-keto-α-boswellic Acid, a Pentacyclic Triterpenoid Inducing Apoptosisin vitroandin vivo
inferredcites →https://doi.org/10.1055/s-2006-951723openalex-snapshotPhysical, Chemical and Pharmacological Characterization of a New Oleogel-Forming Triterpene Extract from the Outer Bark of Birch (Betulae Cortex)
inferredcites →https://doi.org/10.1055/s-2006-957666openalex-snapshotBetulinic Acid: Isolation fromTriphyophyllum peltatumandAncistrocladus heyneanus, Antimalarial Activity, and Crystal Structure of the Benzyl Ester*
inferredcites →https://doi.org/10.1055/s-2007-993745openalex-snapshotEffect of Triterpenoids Isolated from the Floral Spikes of Betula platyphylla var. japonica on P-Glycoprotein Function
inferredcites →https://doi.org/10.1055/s-2008-1034286openalex-snapshotGrowth Inhibition and G1 Cell Cycle Arrest Mediated by 25-Methoxyhispidol A, a Novel Triterpenoid, Isolated from the Fruit of Poncirus trifoliata in Human Hepatocellular Carcinoma Cells
inferredcites →https://doi.org/10.1074/mcp.m700259-mcp200openalex-snapshotProteomics Characterization of the Cytotoxicity Mechanism of Ganoderic Acid D and Computer-automated Estimation of the Possible Drug Target Network
inferredcites →https://doi.org/10.1093/carcin/bgm189openalex-snapshot2-Cyano-lup-1-en-3-oxo-20-oic acid, a cyano derivative of betulinic acid, activates peroxisome proliferator-activated receptor in colon and pancreatic cancer cells
inferredcites →https://doi.org/10.1124/mol.107.041285openalex-snapshotMethyl 2-Cyano-3,11-dioxo-18β-olean-1,12-dien-30-oate Is a Peroxisome Proliferator-Activated Receptor-γ Agonist That Induces Receptor-Independent Apoptosis in LNCaP Prostate Cancer Cells
inferredcites →https://doi.org/10.1128/aac.00737-07openalex-snapshotBetulinic Acid Derivatives That Target gp120 and Inhibit Multiple Genetic Subtypes of Human Immunodeficiency Virus Type 1
inferredcites →https://doi.org/10.1139/v81-385openalex-snapshotCytotoxic diterpenes triptolide, tripdiolide, and cytotoxic triterpenes from tissue cultures of Tripterygium wilfordii
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
inferred← citeshttps://doi.org/10.2139/ssrn.4703506openalex-extractedInhibition of Hela Proliferation and Promotion of Apoptosis by Kuwanon C with an Isopentenyl Group: Disruption of Mitochondria and Endoplasmic Reticulum Normal Structure
inferred← citeshttps://doi.org/10.2139/ssrn.4781594openalex-extractedAntiproliferative Activity and Target Analysis of 18β-Glycyrrhetinic Acid Derivatives Modified with Α, Β-Unsaturated Carbonyl Groups
inferred← citeshttps://doi.org/10.2139/ssrn.4826555openalex-extractedAntiproliferative Activity and Target Analysis of 18β-Glycyrrhetinic Acid Derivatives Modified with Α, Β-Unsaturated Carbonyl Groups
inferred← citeshttps://doi.org/10.1002/bit.26377openalex-snapshotFermentation and purification strategies for the production of betulinic acid and its lupane‐type precursors in Saccharomyces cerevisiae
inferred← citeshttps://doi.org/10.1002/cbdv.202100292openalex-snapshotPlatanic Acid‐Aryl Enones as Potential Anticancer Compounds: Synthesis and Biological Profiling against Breast, Prostate and Lung Cancer Cell Lines
inferred← citeshttps://doi.org/10.1002/chin.201002265openalex-snapshotChemInform Abstract: Anitumor Agents. Part 267. Anti‐AIDS‐Agents. Part 77. Plant‐Derived Triterpenoids and Analogues as Antitumor and anti‐HIV Agents
inferred← citeshttps://doi.org/10.1002/mc.22759openalex-snapshotAntitumor activity of Lepidium latifolium and identification of the epithionitrile 1‐cyano‐2,3‐epithiopropane as its major active component
inferred← citeshttps://doi.org/10.1007/978-3-031-12199-9_6openalex-snapshotHIV and the Role of Various Medicinal Plants Against Infection in Humans, with Possible Mechanism of Action and Functions of Secondary Metabolites
inferred← citeshttps://doi.org/10.1007/s11240-017-1290-8openalex-snapshotProduction of sapogenins (stigmasterol and hecogenin) from genetically transformed hairy root cultures of Chlorophytum borivilianum (Safed musli)
inferred← citeshttps://doi.org/10.1016/j.arabjc.2020.07.022openalex-snapshotPhytochemical investigation and antioxidant activities of methanol extract, methanol fractions and essential oil of Dillenia suffruticosa leaves
inferred← citeshttps://doi.org/10.1016/j.bmc.2021.116494openalex-snapshotMicrobial transformation of pentacyclic triterpenes for anti-inflammatory agents on the HMGB1 stimulated RAW 264.7 cells by Streptomyces olivaceus CICC 23628
inferred← citeshttps://doi.org/10.1016/j.carres.2016.01.010openalex-snapshotInfluence of intramolecular hydrogen bonds on regioselectivity of glycosylation. Synthesis of lupane-type saponins bearing the OSW-1 saponin disaccharide unit and its isomers
inferred← citeshttps://doi.org/10.1016/j.chroma.2012.03.094openalex-snapshotInvestigation of porous graphitic carbon for triterpenoids and natural resinous materials analysis by high performance liquid chromatography hyphenated to mass spectrometry
inferred← citeshttps://doi.org/10.1016/j.ejmech.2024.116635openalex-snapshotAntitumor activity and transcriptome sequencing (RNA-seq) analyses of hepatocellular carcinoma cells in response to exposure triterpene-nucleoside conjugates
inferred← citeshttps://doi.org/10.1016/j.jbc.2024.107839openalex-snapshotChemical genetic analysis of enoxolone inhibition of Clostridioides difficile toxin production reveals adenine deaminase and ATP synthase as antivirulence targets
inferred← citeshttps://doi.org/10.1016/j.jcis.2012.05.020openalex-snapshotInvestigation of the interactions of lupane type pentacyclic triterpenes with outer leaflet membrane phospholipids – Langmuir monolayer and synchrotron X-ray scattering study
inferred← citeshttps://doi.org/10.1016/j.tet.2014.03.006openalex-snapshotSynthesis and structure–activity relationship study of cytotoxic lupane-type 3β-O-monodesmosidic saponins with an extended C-28 side chain
inferred← citeshttps://doi.org/10.1016/j.ydbio.2023.09.010openalex-snapshotTenascin-C-EGFR activation induces functional human satellite cell proliferation and promotes wound-healing of skeletal muscles via oleanic acid
inferred← citeshttps://doi.org/10.1016/j.ymben.2018.10.001openalex-snapshotIdentification of a novel cytochrome P450 enzyme that catalyzes the C-2α hydroxylation of pentacyclic triterpenoids and its application in yeast cell factories
inferred← citeshttps://doi.org/10.1021/acs.chemrev.5b00302openalex-snapshotAlkaloids and Isoprenoids Modification by Copper(I)-Catalyzed Huisgen 1,3-Dipolar Cycloaddition (Click Chemistry): Toward New Functions and Molecular Architectures
inferred← citeshttps://doi.org/10.1021/co500051zopenalex-snapshotSolid-Phase Library Synthesis of Bi-Functional Derivatives of Oleanolic and Maslinic Acids and Their Cytotoxicity on Three Cancer Cell Lines
inferred← citeshttps://doi.org/10.1021/jacs.7b07020openalex-snapshoto -( p -Methoxyphenylethynyl)phenyl Glycosides: Versatile New Glycosylation Donors for the Highly Efficient Construction of Glycosidic Linkages
inferred← citeshttps://doi.org/10.1021/jf1039537openalex-snapshotDetermination of Triterpenic Acids in Human Serum by High-Performance Liquid Chromatography: Triterpenoid Interaction with Serum Protein
inferred← citeshttps://doi.org/10.1021/jm301652topenalex-snapshotDiscovery of a Potential Anti-Inflammatory Agent: 3-Oxo-29-noroleana-1,9(11),12-trien-2,20-dicarbonitrile
inferred← citeshttps://doi.org/10.1038/srep22627openalex-snapshotMevalonate-derived quinonemethide triterpenoid from in vitro roots of Peritassa laevigata and their localization in root tissue by MALDI imaging
inferred← citeshttps://doi.org/10.1039/c0np00069hopenalex-snapshotNatural products and Chagas' disease: a review of plant compounds studied for activity against Trypanosoma cruzi
inferred← citeshttps://doi.org/10.1039/c4md00344fopenalex-snapshot3-(2,6-Dichloro-benzyloxy)-11-oxo-olean-12-ene-29-oic acid, a semisynthetic derivative of glycyrrhetic acid: synthesis, antiproliferative, apoptotic and anti-angiogenesis activity
inferred← citeshttps://doi.org/10.1039/c5np00015gopenalex-snapshotPentacyclic triterpenoids with nitrogen- and sulfur-containing heterocycles: synthesis and medicinal significance
inferred← citeshttps://doi.org/10.1039/c6nj01602bopenalex-snapshotConcise synthesis of a new triterpenoid saponin from the roots of Gypsophila oldhamiana and its derivatives as α-glucosidase inhibitors
inferred← citeshttps://doi.org/10.1039/c6ra04597aopenalex-snapshotDesign, synthesis, and biological evaluation of novel asiatic acid derivatives as potential anticancer agents
inferred← citeshttps://doi.org/10.1055/a-1576-4080openalex-snapshotBiological Activities of Extracts from Ageratum fastigiatum: Phytochemical Study and In Silico Target Fishing Approach
inferred← citeshttps://doi.org/10.1080/10826076.2015.1116092openalex-snapshotSimultaneous determination of five triterpenic acids in fourCorydalisherb medicines by reversed-phase high performance liquid chromatography–fluorescence-mass spectrometer (RP-HPLC–FLD-MS) based on pre-column derivatization
inferred← citeshttps://doi.org/10.1093/jac/dkaf190openalex-snapshotOleanolic acid derivative bardoxolone combats multidrug-resistant Staphylococcus aureus by destroying cell membrane and pyruvate metabolism pathway
inferred← citeshttps://doi.org/10.1101/2022.04.20.488993openalex-snapshotThe licorice metabolite enoxolone attenuates Clostridioides difficile pathophysiology by corrupting its metabolic and toxin production networks
inferred← citeshttps://doi.org/10.1111/cbdd.12543openalex-snapshotSynthesis and Biological Evaluation of Oxygen‐containing Heterocyclic Ring‐fused 23‐Hydroxybetulinic Acid Derivatives as Antitumor Agents
inferred← citeshttps://doi.org/10.1111/cbdd.70190openalex-snapshotAntiproliferative Activity and Target Analysis of 18β‐Glycyrrhetinic Acid Derivatives Modified With α, β‐Unsaturated Carbonyl Groups
inferred← citeshttps://doi.org/10.1134/s1068162013020027openalex-snapshotSynthetic transformations of higher triterpenoids. XXX. Synthesis and cytotoxic activity of betulonic acid amides with fragments of nitroxyl radicals
inferred← citeshttps://doi.org/10.1186/s13765-019-0435-3openalex-snapshotNuclear magnetic resonance assignment strategy for pentacyclic triterpenes, using lup-20(29)-ene from Pilotrichella flexilis as model system, combining spectrally filtered proton-to-carbon schemes and DFT–GIAO approach
inferred← citeshttps://doi.org/10.1248/cpb.59.767openalex-snapshotComposite Constituent: Lactucenyl Acetate, a Novel Migrated Lupane Triterpenoid from Lactuca indica Revision of Structure of Tarolupenyl Acetate
inferred← citeshttps://doi.org/10.18632/oncotarget.27085openalex-snapshotDeep insights into the response of human cervical carcinoma cells to a new cyano enone-bearing triterpenoid soloxolone methyl: a transcriptome analysis
inferred← citeshttps://doi.org/10.19261/cjm.2013.08(2).12openalex-snapshotMolecular Rearrangements of Highly Functionalized Terpenes. An Unique Reactivity of Bicyclic Framework and Polienic Chain Inhibition under Superacidic Treatment
inferred← citeshttps://doi.org/10.3390/ijms25136989openalex-snapshotOleanolic Acid Dimers with Potential Application in Medicine—Design, Synthesis, Physico-Chemical Characteristics, Cytotoxic and Antioxidant Activity
inferred← citeshttps://doi.org/10.3390/ijms25158293openalex-snapshotKuwanon C Inhibits Tumor Cell Proliferation and Induces Apoptosis by Targeting Mitochondria and Endoplasmic Reticulum
inferred← citeshttps://doi.org/10.3390/molecules28124655openalex-snapshotNovel Oleanolic Acid-Phtalimidines Tethered 1,2,3 Triazole Hybrids as Promising Antibacterial Agents: Design, Synthesis, In Vitro Experiments and In Silico Docking Studies
inferred← citeshttps://doi.org/10.3390/ph18111639openalex-snapshotValorization of Olive Leaf Extract via Tailored Liposomal Carriers: Comparative Analysis of Physicochemical Features, Antioxidant Capacity, and Stability
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