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Unique platinum–DNA interactions may lead to more effective platinum-based antitumor drugs

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/1097-0142(197704)39:4<1372::aid-cncr2820390404>3.0.co;2-jopenalex-snapshot

High dose Cis-platinum diammine dichloride.Amelioration of renal toxicity by mannitol diuresis

inferredcites →https://doi.org/10.1002/cmdc.201100141openalex-snapshot

A Tetrazolato‐Bridged Dinuclear Platinum(II) Complex Exhibits Markedly High in vivo Antitumor Activity against Pancreatic Cancer

inferredcites →https://doi.org/10.1007/bf00257407openalex-snapshot

Blood clearance of radioactively labelled cis-diammine 1,1-cyclobutane dicarboxylate platinum(II) (CBDCA) in cancer patients

inferredcites →https://doi.org/10.1007/bf00257742openalex-snapshot

Early clinical studies with cis-diammine-1,1-cyclobutane dicarboxylate platinum II

inferredcites →https://doi.org/10.1007/s00775-004-0541-4openalex-snapshot

Structure–activity relationships in platinum–acridinylthiourea conjugates: effect of the thiourea nonleaving group on drug stability, nucleobase affinity, and in vitro cytotoxicity

inferredcites →https://doi.org/10.1007/s00775-010-0637-yopenalex-snapshot

Characteristic effect of an anticancer dinuclear platinum(II) complex on the higher-order structure of DNA

inferredcites →https://doi.org/10.1007/s00775-010-0733-zopenalex-snapshot

Rates of intercalator-driven platination of DNA determined by a restriction enzyme cleavage inhibition assay

inferredcites →https://doi.org/10.1016/0006-2952(81)90546-3openalex-snapshot

Studies on the resistance of a murine leukemia L1210 cell line to cis-diamminedichloroplatinium(II)

inferredcites →https://doi.org/10.1016/0753-3322(89)90004-8openalex-snapshot

Antitumor activity of a new platinum complex, oxalato (trans-l-1,2-diaminocyclohexane)platinum (II): new experimental data

inferredcites →https://doi.org/10.1016/j.jinorgbio.2004.07.012openalex-snapshot

Synthesis and DNA conformational changes of non-covalent polynuclear platinum complexes

inferredcites →https://doi.org/10.1016/j.jinorgbio.2010.04.005openalex-snapshot

Structure of duplex DNA containing the cisplatin 1,2-{Pt(NH3)2}2+-d(GpG) cross-link at 1.77Å resolution

inferredcites →https://doi.org/10.1016/s0272-6386(86)80111-1openalex-snapshot

Cisplatin Nephrotoxicity

inferredcites →https://doi.org/10.1021/bi050021bopenalex-snapshot

Solution Structural Study of a DNA Duplex Containing the Guanine-N7 Adduct Formed by a Cytotoxic Platinum−Acridine Hybrid Agent,

inferredcites →https://doi.org/10.1021/cr980421nopenalex-snapshot

Structure, Recognition, and Processing of Cisplatin−DNA Adducts

inferredcites →https://doi.org/10.1021/ic000273vopenalex-snapshot

New Antitumor-Active Azole-Bridged Dinuclear Platinum(II) Complexes: Synthesis, Characterization, Crystal Structures, and Cytotoxic Studies

inferredcites →https://doi.org/10.1021/ic051390zopenalex-snapshot

Synthesis, Characterization, and Cytotoxicity of a Novel Highly Charged Trinuclear Platinum Compound. Enhancement of Cellular Uptake with Charge

inferredcites →https://doi.org/10.1021/ja0168559openalex-snapshot

A Novel Isomerization on Interaction of Antitumor-Active Azole-Bridged Dinuclear Platinum(II) Complexes with 9-Ethylguanine. Platinum(II) Atom Migration from N2 to N3 on 1,2,3-Triazole

inferredcites →https://doi.org/10.1021/ja062851yopenalex-snapshot

A Third Mode of DNA Binding: Phosphate Clamps by a Polynuclear Platinum Complex

inferredcites →https://doi.org/10.1021/jm010293mopenalex-snapshot

Design, Synthesis, and Biological Activity of a Novel Non-Cisplatin-type Platinum−Acridine Pharmacophore

inferredcites →https://doi.org/10.1021/jm800900gopenalex-snapshot

A Non-Cross-Linking Platinum−Acridine Agent with Potent Activity in Non-Small-Cell Lung Cancer

inferredcites →https://doi.org/10.1021/jm900451yopenalex-snapshot

Replacement of a Thiourea-S with an Amidine-NH Donor Group in a Platinum−Acridine Antitumor Compound Reduces the Metal’s Reactivity with Cysteine Sulfur

inferredcites →https://doi.org/10.1021/jp054828popenalex-snapshot

Binding of Novel Azole-Bridged Dinuclear Platinum(II) Anticancer Drugs to DNA: Insights from Hybrid QM/MM Molecular Dynamics Simulations

inferredcites →https://doi.org/10.1038/206999a0openalex-snapshot

Template Deoxyribonucleic Acid and the Control of Replication

inferredcites →https://doi.org/10.1038/222385a0openalex-snapshot

Platinum Compounds: a New Class of Potent Antitumour Agents

inferredcites →https://doi.org/10.1038/377649a0openalex-snapshot

Crystal structure of double-stranded DNA containing the major adduct of the anticancer drug cisplatin

inferredcites →https://doi.org/10.1038/bjc.1998.429openalex-snapshot

Ongoing and unsaid on oxaliplatin: the hope

inferredcites →https://doi.org/10.1039/a903081fopenalex-snapshot

An NMR study and crystal structure of [{cis-Pt(NH3)2(9EtG-κN7)}2(μ-pz)][NO3]3 (9EtG = 9-ethylguanine) as a model compound for the 1,2-intrastrand GG crosslink †

inferredcites →https://doi.org/10.1039/b907567dopenalex-snapshot

Inhibition of transcription by platinum antitumor compounds

inferredcites →https://doi.org/10.1039/c0cc01254hopenalex-snapshot

Excursions in polynuclear platinum DNA binding

inferredcites →https://doi.org/10.1093/nar/gkg465openalex-snapshot

Unusual intercalation of acridin-9-ylthiourea into the 5'-GA/TC DNA base step from the minor groove: implications for the covalent DNA adduct profile of a novel platinum-intercalator conjugate

inferredcites →https://doi.org/10.1093/nar/gkq723openalex-snapshot

The phosphate clamp: a small and independent motif for nucleic acid backbone recognition

inferredcites →https://doi.org/10.1093/nar/gkq803openalex-snapshot

Walking of antitumor bifunctional trinuclear Pt II complex on double-helical DNA

inferredcites →https://doi.org/10.1146/annurev.pharmtox.48.080907.180426openalex-snapshot

The Role of Cellular Accumulation in Determining Sensitivity to Platinum-Based Chemotherapy

inferredcites →https://doi.org/10.1158/1078-0432.ccr-07-2238openalex-snapshot

Platinum Resistance: The Role of DNA Repair Pathways

inferredcites →https://doi.org/10.1351/pac200880122595openalex-snapshot

Metallomics study on all-elements analysis of salmon egg cells and fractionation analysis of metals in cell cytoplasm

inferredcites →https://doi.org/10.2174/092986709787458452openalex-snapshot

Metallothioneins and Platinum(II) Anti-Tumor Compounds

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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inferred← citeshttps://doi.org/10.1016/j.cplett.2017.04.039openalex-snapshot

Conformational transition of DNA by dinuclear Pt(II) complexes causes cooperative inhibition of gene expression

inferred← citeshttps://doi.org/10.1016/j.dib.2021.107697openalex-snapshot

Data on synthesis and structure–activity relationships of tetrazolato-bridged dinuclear platinum(II) complexes

inferred← citeshttps://doi.org/10.1016/j.drudis.2019.02.012openalex-snapshot

Anticancer activity of palladium-based complexes against triple-negative breast cancer

inferred← citeshttps://doi.org/10.1016/j.ica.2018.09.070openalex-snapshot

Synthesis, spectroscopic characterization and in vitro cytotoxic as well as docking studies of cis-diammine platinum(II) complexes of thiones

inferred← citeshttps://doi.org/10.1016/j.inoche.2013.08.019openalex-snapshot

Synthesis, crystal structure and antimicrobial studies of a thione derivative of transplatin, trans-[Pt(NH3)2(Diaz)2]Cl2·2H2O (Diaz = 1,3-diazinane-2-thione)

inferred← citeshttps://doi.org/10.1016/j.jinorgbio.2012.04.015openalex-snapshot

DNA conformation and repair of polymeric natural DNA damaged by antitumor azolato-bridged dinuclear PtII complex

inferred← citeshttps://doi.org/10.1016/j.jinorgbio.2017.08.010openalex-snapshot

Kinetic analysis of and platinum(II) migration in the reactions of tetrazolato-bridged dinuclear platinum(II) complexes with nucleotides

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Synthesis and structure–activity relationships of tetrazolato-bridged dinuclear platinum(II) complexes: A small modification at tetrazole C5 markedly influences the in vivo antitumor efficacy

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Kinetic aspects of platinum anticancer agents

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Specific Conformational Change in Giant DNA Caused by Anticancer Tetrazolato-Bridged Dinuclear Platinum(II) Complexes: Middle-Length Alkyl Substituents Exhibit Minimum Effect

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Impact of the Pd2Spermine Chelate on Osteosarcoma Metabolism: An NMR Metabolomics Study

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Highly Efficient DNA Compaction Mediated by an In Vivo Antitumor-Active Tetrazolato-Bridged Dinuclear Platinum(II) Complex

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Synthesis, Aqueous Reactivity, and Biological Evaluation of Carboxylic Acid Ester-Functionalized Platinum–Acridine Hybrid Anticancer Agents

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Using a Build-and-Click Approach for Producing Structural and Functional Diversity in DNA-Targeted Hybrid Anticancer Agents

inferred← citeshttps://doi.org/10.1038/srep24712openalex-snapshot

Chromatin folding and DNA replication inhibition mediated by a highly antitumor-active tetrazolato-bridged dinuclear platinum(II) complex

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