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Absorption and disposition of naringenin and quercetin after simultaneous administration via intestinal perfusion in mice

https://doi.org/10.1039/c6fo00633g
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/jps.20309openalex-snapshot
Prediction of in vivo intestinal absorption enhancement on P-glycoprotein inhibition, from rat in situ permeability
inferredcites →https://doi.org/10.1002/jps.21851openalex-snapshot
Modulation of the activity of ABC transporters (P-glycoprotein, MRP2, BCRP) by flavonoids and drug response
inferredcites →https://doi.org/10.1002/mnfr.201300234openalex-snapshot
Plasma metabolites of dietary flavonoids after combination meal consumption with onion and tofu in humans
inferredcites →https://doi.org/10.1007/s11095-005-4584-1openalex-snapshot
Pharmacokinetics and Modeling of Quercetin and Metabolites
inferredcites →https://doi.org/10.1016/0378-5173(80)90140-4openalex-snapshot
Quantitative mechanistic studies in simultaneous fluid flow and intestinal absorption using steroids as model solutes
inferredcites →https://doi.org/10.1016/j.ejpb.2003.11.002openalex-snapshot
Enhanced paclitaxel bioavailability after oral administration of paclitaxel or prodrug to rats pretreated with quercetin
inferredcites →https://doi.org/10.1016/j.ejphar.2008.03.008openalex-snapshot
Health effects of quercetin: From antioxidant to nutraceutical
inferredcites →https://doi.org/10.1016/j.ejps.2005.03.001openalex-snapshot
Modulation of drug transport by selected flavonoids: Involvement of P-gp and OCT?
inferredcites →https://doi.org/10.1016/j.ejps.2008.10.013openalex-snapshot
Segmental-dependent membrane permeability along the intestine following oral drug administration: Evaluation of a triple single-pass intestinal perfusion (TSPIP) approach in the rat
inferredcites →https://doi.org/10.1016/j.ejps.2014.09.004openalex-snapshot
Interactions between active pharmaceutical ingredients and excipients affecting bioavailability: Impact on bioequivalence
inferredcites →https://doi.org/10.1016/j.fct.2008.02.010openalex-snapshot
Activation of EpRE-mediated gene transcription by quercetin glucuronides depends on their deconjugation
inferredcites →https://doi.org/10.1016/j.fitote.2013.10.010openalex-snapshot
Synergy effects of herb extracts: Pharmacokinetics and pharmacodynamic basis
inferredcites →https://doi.org/10.1016/j.foodchem.2011.07.078openalex-snapshot
Oil matrix effects on plasma exposure and urinary excretion of phenolic compounds from tomato sauces: Evidence from a human pilot study
inferredcites →https://doi.org/10.1016/j.foodchem.2014.09.156openalex-snapshot
The tomato sauce making process affects the bioaccessibility and bioavailability of tomato phenolics: A pharmacokinetic study
inferredcites →https://doi.org/10.1016/j.ijpharm.2004.01.032openalex-snapshot
Enhanced bioavailability of paclitaxel after oral coadministration with flavone in rats
inferredcites →https://doi.org/10.1016/j.ijpharm.2008.09.023openalex-snapshot
Studies of intestinal permeability of 36 flavonoids using Caco-2 cell monolayer model
inferredcites →https://doi.org/10.1016/j.lfs.2003.06.044openalex-snapshot
Lethal quercetin-digoxin interaction in pigs
inferredcites →https://doi.org/10.1016/j.lfs.2005.03.033openalex-snapshot
Co-administration of quercetin and catechin in rats alters their absorption but not their metabolism
inferredcites →https://doi.org/10.1016/j.nutres.2004.07.005openalex-snapshot
Review of the flavonoids quercetin, hesperetin, and naringenin. Dietary sources, bioactivities, bioavailability, and epidemiology
inferredcites →https://doi.org/10.1016/s0006-2952(02)01510-1openalex-snapshot
Metabolism of quercetin-7- and quercetin-3-glucuronides by an in vitro hepatic model: the role of human β-glucuronidase, sulfotransferase, catechol-O-methyltransferase and multi-resistant protein 2 (MRP2) in flavonoid metabolism
inferredcites →https://doi.org/10.1016/s0006-2952(98)00048-3openalex-snapshot
Transport of Quercetin and Its Glucosides across Human Intestinal Epithelial Caco-2 Cells
inferredcites →https://doi.org/10.1016/s0014-2999(00)00180-1openalex-snapshot
Effect of bioflavonoids on vincristine transport across blood–brain barrier
inferredcites →https://doi.org/10.1016/s0304-4017(03)00008-6openalex-snapshot
Enhancement of moxidectin bioavailability in lamb by a natural flavonoid: quercetin
inferredcites →https://doi.org/10.1016/s0891-5849(00)00195-7openalex-snapshot
Bioavailability and metabolism of the flavonol quercetin in the pig
inferredcites →https://doi.org/10.1017/s0007114515000537openalex-snapshot
Simultaneous ingestion of high-methoxy pectin from apple can enhance absorption of quercetin in human subjects
inferredcites →https://doi.org/10.1017/s0007114515001671openalex-snapshot
High gastrointestinal permeability and local metabolism of naringenin: influence of antibiotic treatment on absorption and metabolism
inferredcites →https://doi.org/10.1021/jf0483669openalex-snapshot
Experimental Determination of Octanol−Water Partition Coefficients of Quercetin and Related Flavonoids
inferredcites →https://doi.org/10.1021/jf0728451openalex-snapshot
Effect of Grapefruit Juice, Naringin, Naringenin, and Bergamottin on the Intestinal Carrier-Mediated Transport of Talinolol in Rats
inferredcites →https://doi.org/10.1021/mp300410nopenalex-snapshot
Comparison of the Permeability of Metoprolol and Labetalol in Rat, Mouse, and Caco-2 Cells: Use as a Reference Standard for BCS Classification
inferredcites →https://doi.org/10.1021/mp900013dopenalex-snapshot
Disposition of Naringenin via Glucuronidation Pathway Is Affected by Compensating Efflux Transporters of Hydrophilic Glucuronides
inferredcites →https://doi.org/10.1023/a:1007506222436openalex-snapshot
Induction of UDP-Glucuronosyl-Transferase by the Flavonoids Chrysin and Quercetin in Caco-2 Cells
inferredcites →https://doi.org/10.1023/a:1016212804288openalex-snapshot
A Theoretical Basis for a Biopharmaceutic Drug Classification: The Correlation of in Vitro Drug Product Dissolution and in Vivo Bioavailability
inferredcites →https://doi.org/10.1038/ejcn.2010.6openalex-snapshot
Relative bioavailability of the flavonoids quercetin, hesperetin and naringenin given simultaneously through diet
inferredcites →https://doi.org/10.1039/c2ra01369jopenalex-snapshot
Mutual interactions between flavonoids and enzymatic and transporter elements responsible for flavonoid disposition via phase II metabolic pathways
inferredcites →https://doi.org/10.1046/j.1365-2125.1999.00052.xopenalex-snapshot
Inhibition of the CYP3A4‐mediated metabolism and P‐glycoprotein‐mediated transport of the HIV‐1 protease inhibitor saquinavir by grapefruit juice components
inferredcites →https://doi.org/10.1055/s-2004-832686openalex-snapshot
Modulation of P-Glycoprotein Function by St John’s Wort Extract and its Major Constituents
inferredcites →https://doi.org/10.1067/mcp.2002.121152openalex-snapshot
Fruit juices inhibit organic anion transporting polypeptide–mediated drug uptake to decrease the oral availability of fexofenadine
inferredcites →https://doi.org/10.1079/bjn20061809openalex-snapshot
Absorption, excretion and metabolite profiling of methyl-, glucuronyl-, glucosyl- and sulpho-conjugates of quercetin in human plasma and urine after ingestion of onions
inferredcites →https://doi.org/10.1080/00498250110069159openalex-snapshot
Differential inhibition of human liver and duodenum sulphotransferase activities by quercetin, a flavonoid present in vegetables, fruit and wine
inferredcites →https://doi.org/10.1080/10408690390826437openalex-snapshot
Tomatoes and Cardiovascular Health
inferredcites →https://doi.org/10.1093/ajcn/81.1.230sopenalex-snapshot
Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies
inferredcites →https://doi.org/10.1093/jn/136.1.39openalex-snapshot
Rat Gastrointestinal Tissues Metabolize Quercetin ,
inferredcites →https://doi.org/10.1111/j.1745-7254.2008.00884.xopenalex-snapshot
Intra-herb pharmacokinetics interaction between quercetin and isorhamentin
inferredcites →https://doi.org/10.1124/dmd.105.005926openalex-snapshot
FLAVONOIDS AS A NOVEL CLASS OF HUMAN ORGANIC ANION-TRANSPORTING POLYPEPTIDE OATP1B1 (OATP-C) MODULATORS
inferredcites →https://doi.org/10.1124/dmd.31.6.805openalex-snapshot
ABSORPTION/METABOLISM OF SULFORAPHANE AND QUERCETIN, AND REGULATION OF PHASE II ENZYMES, IN HUMAN JEJUNUM IN VIVO
inferredcites →https://doi.org/10.1124/dmd.32.4.387openalex-snapshot
NEW METABOLIC PATHWAYS FOR FLAVANONES CATALYZED BY RAT LIVER MICROSOMES
inferredcites →https://doi.org/10.1124/mol.59.5.1171openalex-snapshot
Modulation of Multidrug Resistance Protein 1 (MRP1/ABCC1) Transport and ATPase Activities by Interaction with Dietary Flavonoids
inferredcites →https://doi.org/10.1158/1940-6207.capr-08-0101openalex-snapshot
Stabilization of Quercetin Paradoxically Reduces Its Proapoptotic Effect on UVB-Irradiated Human Keratinocytes
inferredcites →https://doi.org/10.1177/00912700122010366openalex-snapshot
Pharmacokinetics and Bioavailability of Quercetin Glycosides in Humans
inferredcites →https://doi.org/10.1208/ps030325openalex-snapshot
Comparison of the gravimetric, phenol red, and 14C-PEG-3350 methods to determine water absorption in the rat single-pass intestinal perfusion model
inferredcites →https://doi.org/10.1211/0022357044814openalex-snapshot
The effect of quercetin on the pharmacokinetics of verapamil and its major metabolite, norverapamil, in rabbits
inferredcites →https://doi.org/10.1211/jpp.61.11.0006openalex-snapshot
Quercetin and naringenin transport across human intestinal Caco-2 cells
inferredcites →https://doi.org/10.1271/bbb.70.279openalex-snapshot
Effects of Combined Administration of Quercetin, Rutin, and Extract of White Radish Sprout Rich in Kaempferol Glycosides on the Metabolism in Rats
inferredcites →https://doi.org/10.14200/jrm.2014.3.0108openalex-snapshot
Combination Effects of Quercetin, Resveratrol and Curcumin on In Vitro Intestinal Absorption
inferredcites →https://doi.org/10.1517/17425255.4.1.17openalex-snapshot
Effect of dietary flavonoids on pathways involved in drug metabolism

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Unraveling Quercetin's Potential: A Comprehensive Review of Its Properties and Mechanisms of Action, in Diabetes and Obesity Complications
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Dietary Flavonols and O-Glycosides
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Engineering artificial fusion naringinase for enhancing naringenin biosynthesis
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Roles and mechanisms of quercetin on cardiac arrhythmia: A review
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Interaction of luteolin, naringenin, and their sulfate and glucuronide conjugates with human serum albumin, cytochrome P450 (CYP2C9, CYP2C19, and CYP3A4) enzymes and organic anion transporting polypeptide (OATP1B1 and OATP2B1) transporters
inferred← citeshttps://doi.org/10.1016/j.foodchem.2024.140262openalex-snapshot
The bioavailability, absorption, metabolism, and regulation of glucolipid metabolism disorders by quercetin and its important glycosides: A review
inferred← citeshttps://doi.org/10.1016/j.foohum.2023.12.010openalex-snapshot
The influence of food matrix on the stability and bioavailability of phytochemicals: A comprehensive review
inferred← citeshttps://doi.org/10.1016/j.jddst.2020.101874openalex-snapshot
The isonicotinamide cocrystal promotes inhibitory effects of naringenin on nonalcoholic fatty liver disease in mice
inferred← citeshttps://doi.org/10.1016/j.jnutbio.2022.108967openalex-snapshot
Beneficial effects of citrus flavanones naringin and naringenin and their food sources on lipid metabolism: An update on bioavailability, pharmacokinetics, and mechanisms
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Double-responsive hyaluronic acid-based prodrugs for efficient tumour targeting
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Alginate and hyaluronic acid-based prodrugs: Synthesis, properties, and biomedical applications
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Effect of food matrix on the content and bioavailability of flavonoids
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Smart Responsive Quercetin-Conjugated Glycol Chitosan Prodrug Micelles for Treatment of Inflammatory Bowel Diseases
inferred← citeshttps://doi.org/10.1021/acsomega.3c08785openalex-snapshot
Bioactive Wound Healing 3D Structure Based on Chitosan Hydrogel Loaded with Naringin/Cyclodextrin Inclusion Nanocomplex
inferred← citeshttps://doi.org/10.1080/00498254.2026.2720198openalex-snapshot
Inhibiting CYP2A5 enzyme in mice decreases circulating cotinine after nicotine administration and increases dopamine in the brain
inferred← citeshttps://doi.org/10.1080/1028415x.2019.1594554openalex-snapshot
Naringenin, a dietary flavanone, enhances insulin-like growth factor 1 receptor-mediated antioxidant defense and attenuates methylglyoxal-induced neurite damage and apoptotic death
inferred← citeshttps://doi.org/10.1080/10408398.2019.1679085openalex-snapshot
The pharmacokinetics of flavanones
inferred← citeshttps://doi.org/10.1111/1541-4337.13057openalex-snapshot
Review of factors affecting citrus polyphenol bioavailability and their importance in designing in vitro, animal, and intervention studies
inferred← citeshttps://doi.org/10.1111/jphp.12929openalex-snapshot
Intestinal disposition of quercetin and its phase-II metabolites after oral administration in healthy volunteers
inferred← citeshttps://doi.org/10.2147/cia.s516946openalex-snapshot
Targeting Senescence, Oxidative Stress, and Inflammation: Quercetin-Based Strategies for Ocular Diseases in Older Adults
inferred← citeshttps://doi.org/10.3389/fphar.2025.1523905openalex-snapshot
Multi-target mechanisms and potential applications of quercetin in the treatment of acne vulgaris
inferred← citeshttps://doi.org/10.3390/biology14121705openalex-snapshot
Dietary Polyphenols-Gut Microbiota Interactions: Intervention Strategies and Metabolic Regulation for Intestinal Diseases
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Acute Effect of a Single Dose of Tomato Sofrito on Plasmatic Inflammatory Biomarkers in Healthy Men
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Variability in the Beneficial Effects of Phenolic Compounds: A Review
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