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A high concentration of fatty acids induces TNF-α as well as NO release mediated by the P2X4 receptor, and the protective effects of puerarin in RAW264.7 cells

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/iub.1470openalex-snapshot

PGC‐1β suppresses saturated fatty acid‐induced macrophage inflammation by inhibiting TAK1 activation

inferredcites →https://doi.org/10.1002/ptr.5151openalex-snapshot

Inhibition of LPS‐Induced TNF‐α and NO Production in Mouse Macrophage and Inflammatory Response in Rat Animal Models by a Novel Ayurvedic Formulation, BV‐9238

inferredcites →https://doi.org/10.1002/ptr.5666openalex-snapshot

Puerarin Exerts an Antiinflammatory Effect by Inhibiting NF-kB and MAPK Activation inStaphylococcus aureus-Induced Mastitis

inferredcites →https://doi.org/10.1007/s00125-004-1589-yopenalex-snapshot

Chronic exposure to high glucose impairs bradykinin-stimulated nitric oxide production by interfering with the phospholipase-C-implicated signalling pathway in endothelial cells: evidence for the involvement of protein kinase C

inferredcites →https://doi.org/10.1007/s00281-016-0555-3openalex-snapshot

The role of airway macrophages in apoptotic cell clearance following acute and chronic lung inflammation

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Inhibition of P2X4 Suppresses Joint Inflammation and Damage in Collagen-Induced Arthritis

inferredcites →https://doi.org/10.1007/s10753-014-0036-6openalex-snapshot

Trans-Resveratrol Attenuates High Fatty Acid-Induced P2X7 Receptor Expression and IL-6 Release in PC12 Cells: Possible Role of P38 MAPK Pathway

inferredcites →https://doi.org/10.1007/s11302-015-9493-0openalex-snapshot

P2X ion channel receptors and inflammation

inferredcites →https://doi.org/10.1007/s11302-016-9500-0openalex-snapshot

LncRNA NONRATT021972 siRNA attenuates P2X7 receptor expression and inflammatory cytokine production induced by combined high glucose and free fatty acids in PC12 cells

inferredcites →https://doi.org/10.1007/s11883-016-0585-2openalex-snapshot

Macrophages in Vascular Inflammation: Origins and Functions

inferredcites →https://doi.org/10.1016/j.bbrc.2012.02.122openalex-snapshot

Regulation of P2X7-dependent inflammatory functions by P2X4 receptor in mouse macrophages

inferredcites →https://doi.org/10.1016/j.biocel.2013.02.009openalex-snapshot

ATP-P2X4 signaling mediates NLRP3 inflammasome activation: A novel pathway of diabetic nephropathy

inferredcites →https://doi.org/10.1016/j.brainresbull.2013.02.002openalex-snapshot

High fatty acids modulate P2X7 expression and IL-6 release via the p38 MAPK pathway in PC12 cells

inferredcites →https://doi.org/10.1016/j.fct.2014.06.017openalex-snapshot

Puerarin ameliorates carbon tetrachloride-induced oxidative DNA damage and inflammation in mouse kidney through ERK/Nrf2/ARE pathway

inferredcites →https://doi.org/10.1016/j.foodchem.2016.06.018openalex-snapshot

Effect of pecan phenolics on the release of nitric oxide from murine RAW 264.7 macrophage cells

inferredcites →https://doi.org/10.1016/j.freeradbiomed.2008.12.001openalex-snapshot

Fatty acid transduction of nitric oxide signaling: nitrolinoleic acid mediates protective effects through regulation of the ERK pathway

inferredcites →https://doi.org/10.1016/j.intimp.2006.08.015openalex-snapshot

Anti-inflammatory effects of short chain fatty acids in IFN-γ-stimulated RAW 264.7 murine macrophage cells: Involvement of NF-κB and ERK signaling pathways

inferredcites →https://doi.org/10.1016/j.intimp.2013.12.027openalex-snapshot

Maleylated-BSA suppresses lipopolysaccharide-induced IL-6 production by activating the ERK-signaling pathway in murine RAW264.7 cells

inferredcites →https://doi.org/10.1016/j.intimp.2015.08.020openalex-snapshot

Beneficial effects of evodiamine on P2X4-mediated inflammatory injury of human umbilical vein endothelial cells due to high glucose

inferredcites →https://doi.org/10.1016/j.jep.2012.02.038openalex-snapshot

Puerarin exerts antipyretic effect on lipopolysaccharide-induced fever in rats involving inhibition of pyrogen production from macrophages

inferredcites →https://doi.org/10.1016/j.jnutbio.2016.03.017openalex-snapshot

The role of free fatty acids in the inflammatory and cardiometabolic profile in adolescents with metabolic syndrome engaged in interdisciplinary therapy

inferredcites →https://doi.org/10.1016/j.neuint.2014.01.011openalex-snapshot

P2X4 receptors expressed on microglial cells in post-ischemic inflammation of brain ischemic injury

inferredcites →https://doi.org/10.1016/j.phrs.2016.06.022openalex-snapshot

Stauntoside B inhibits macrophage activation by inhibiting NF-κB and ERK MAPK signalling

inferredcites →https://doi.org/10.1016/j.phymed.2012.07.010openalex-snapshot

Upregulation of osteoblastic differentiation marker mRNA expression in osteoblast-like UMR106 cells by puerarin and phytoestrogens from Pueraria mirifica

inferredcites →https://doi.org/10.1016/j.tiv.2013.09.001openalex-snapshot

Homocysteine modifies extracellular ATP availability in macrophages

inferredcites →https://doi.org/10.1038/cddis.2014.70openalex-snapshot

Extracellular ATP drives systemic inflammation, tissue damage and mortality

inferredcites →https://doi.org/10.1038/nature08198openalex-snapshot

Crystal structure of the ATP-gated P2X4 ion channel in the closed state

inferredcites →https://doi.org/10.1097/00006676-199811000-00009openalex-snapshot

Involvement of Lipid Peroxidation in Free Fatty Acid-Induced Isolated Rat Pancreatic Acinar Cell Injury

inferredcites →https://doi.org/10.1111/j.1365-3083.2010.02404.xopenalex-snapshot

Chitinase Induce the Release of IL‐8 in Human Airway Epithelial Cells, Via Ca2+‐dependent PKC and ERK Pathways

inferredcites →https://doi.org/10.1111/jre.12261openalex-snapshot

Puerarin decreases bone loss and collagen destruction in rats with ligature‐induced periodontitis

inferredcites →https://doi.org/10.1146/annurev.iy.01.040183.002003openalex-snapshot

Mediators of Inflammation

inferredcites →https://doi.org/10.1152/ajpcell.00175.2012openalex-snapshot

Pannexin1 contributes to pathophysiological ATP release in lipoapoptosis induced by saturated free fatty acids in liver cells

inferredcites →https://doi.org/10.1155/2014/485927openalex-snapshot

Puerarin Alleviates Neuropathic Pain by Inhibiting Neuroinflammation in Spinal Cord

inferredcites →https://doi.org/10.1161/atvbaha.115.307397openalex-snapshot

Extracellular ATP Induces Vascular Inflammation and Atherosclerosis via Purinergic Receptor Y 2 in Mice

inferredcites →https://doi.org/10.1186/1471-2261-14-159openalex-snapshot

Association between serum free fatty acid levels and possible related factors in patients with type 2 diabetes mellitus and acute myocardial infarction

inferredcites →https://doi.org/10.1194/jlr.m039347openalex-snapshot

Saturated fatty acids activate ERK signaling to downregulate hepatic sortilin 1 in obese and diabetic mice

inferredcites →https://doi.org/10.1371/journal.pmed.1002094openalex-snapshot

Association of Plasma Phospholipid n-3 and n-6 Polyunsaturated Fatty Acids with Type 2 Diabetes: The EPIC-InterAct Case-Cohort Study

inferredcites →https://doi.org/10.1371/journal.pone.0125111openalex-snapshot

The ATP Receptors P2X7 and P2X4 Modulate High Glucose and Palmitate-Induced Inflammatory Responses in Endothelial Cells

inferredcites →https://doi.org/10.1530/jme-11-0082openalex-snapshot

Chronic exposure to high fatty acids impedes receptor agonist-induced nitric oxide production and increments of cytosolic Ca2+ levels in endothelial cells

inferredcites →https://doi.org/10.2174/0929867322666141210155311openalex-snapshot

P2X Receptors and Inflammation

inferredcites →https://doi.org/10.3177/jnsv.62.425openalex-snapshot

Puerarin Suppresses Macrophage Activation via Antioxidant Mechanisms in a CaPO4-Induced Mouse Model of Aneurysm

inferredcites →https://doi.org/10.3892/mmr.2016.5187openalex-snapshot

Tetrandrine suppresses β-glucan-induced macrophage activation via inhibiting NF-κB, ERK and STAT3 signaling pathways

inferredcites →https://doi.org/10.4049/jimmunol.181.3.2181openalex-snapshot

Activation of Human Alveolar Macrophages via P2 Receptors: Coupling to Intracellular Ca2+ Increases and Cytokine Secretion

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Efficacy and Safety Of Combined Chinese and Western Medicine in the Treatment of Metabolic Syndrome: A Network Meta-Analysis of Randomized Controlled Trials

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Correlations between Serum P2X7, Vitamin A, 25‐hydroxy Vitamin D, and Mycoplasma Pneumoniae Pneumonia

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UPLC-Q-TOF–MS and network pharmacology to reveal the mechanism of Guizhi Gegen decoction against type 2 diabetes mellitus

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Duloxetine ameliorates lipopolysaccharide-induced microglial activation by suppressing iNOS expression in BV-2 microglial cells

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RETRACTED ARTICLE: Anti-inflammatory Effects of Novel P2X4 Receptor Antagonists, NC-2600 and NP-1815-PX, in a Murine Model of Colitis

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Antiinflammatory activity of natural dietary flavonoids

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Microneedle-facilitated Portulaca oleracea L.-derived nanovesicles ameliorate atopic dermatitis by modulating macrophage M1/M2 polarization and inhibiting NF-κB and STING signaling pathways

inferred← citeshttps://doi.org/10.1016/j.biopha.2024.117319openalex-snapshot

Protective effects of puerarin on metabolic diseases: Emphasis on the therapeutical effects and the underlying molecular mechanisms

inferred← citeshttps://doi.org/10.1016/j.ejphar.2021.174729openalex-snapshot

The mechanism by which ATP regulates alcoholic steatohepatitis through P2X4 and CD39

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Plant natural products as source of new P2 receptors ligands

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Metabolomics of the anti-inflammatory effect of Pueraria lobata and Pueraria lobata var. Thomsonii in rats

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Roles and mechanisms of Pueraria lobata radix in metabolic dysfunction-associated steatotic liver disease

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Therapeutic potential of targeting novel signaling pathways in regulating chronic inflammation in obstructive lung disorders

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The therapeutic potential of puerarin on diabetic kidney disease: Focus on molecular mechanisms and future perspectives

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P2X4 Receptor Antagonists Exert Anti-Inflammatory Effects via NLRP3 Inflammasome in a Murine Model of Colitis

inferred← citeshttps://doi.org/10.1038/s41598-023-40748-8openalex-snapshot

Purinergic neurotransmission receptor P2X4 silencing alleviates intracerebral hemorrhage-induced neuroinflammation by blocking the NLRP1/Caspase-1 pathway

inferred← citeshttps://doi.org/10.1039/c9bm00111eopenalex-snapshot

Synthesis, characterization, and formulation of poly-puerarin as a biodegradable and biosafe drug delivery platform for anti-cancer therapy

inferred← citeshttps://doi.org/10.1039/d1fo03712aopenalex-snapshot

Potential active constituents responsible for treating acute pharyngitis in the flowers of Hosta plantaginea (Lam.) Aschers and their pharmacokinetics

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Purinergic receptor ligands: the cytokine storm attenuators, potential therapeutic agents for the treatment of COVID-19

inferred← citeshttps://doi.org/10.1080/10799893.2021.1878536openalex-snapshot

Catestatin enhances ATP-induced activation of glial cells mediated by purinergic receptor P2X4

inferred← citeshttps://doi.org/10.1097/md.0000000000044711openalex-snapshot

Exploring the potential causal association between oral microbiota and heart failure using Mendelian randomization in an East Asian population

inferred← citeshttps://doi.org/10.1111/bph.70127openalex-snapshot

Effects of the P2RX4 antagonist BR11595 in a guinea pig model of chronic asthma

inferred← citeshttps://doi.org/10.1142/s0192415x18500891openalex-snapshot

Management of Diabetes Mellitus with Puerarin, a Natural Isoflavone FromPueraria lobata

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Use of Network Pharmacology to Explore the Mechanism of Gegen (Puerariae lobatae Radix) in the Treatment of Type 2 Diabetes Mellitus Associated with Hyperlipidemia

inferred← citeshttps://doi.org/10.2147/dmso.s186505openalex-snapshot

Elevated free fatty acid level is associated with insulin-resistant state in nondiabetic Chinese people

inferred← citeshttps://doi.org/10.2174/0118715303287050240223073217openalex-snapshot

Puerarin: A Potential Supplement for Diabetes and its Complications

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Tumor necrosis factor-α promotes lipolysis and reduces insulin sensitivity by activating nuclear factor kappa B and c-Jun N-terminal kinase in primary bovine adipocytes

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Puerarin as a Potential Drug Candidate for the Management of Type-2 Diabetes: Molecular Docking and Pharmacophore Modeling Studies

inferred← citeshttps://doi.org/10.3389/fendo.2023.1181948openalex-snapshot

Role of purinergic signalling in obesity-associated end-organ damage: focus on the effects of natural plant extracts

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Treatment of T2DM-related inflammation and vascular injury by regulating cellular crosstalk in the islet microenvironment

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Puerarin Attenuates Obesity-Induced Inflammation and Dyslipidemia by Regulating Macrophages and TNF-Alpha in Obese Mice

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P2Y2 and P2X4 Receptors Mediate Ca2+ Mobilization in DH82 Canine Macrophage Cells

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Cardioprotective Effects of Puerarin-V on Isoproterenol-Induced Myocardial Infarction Mice Is Associated with Regulation of PPAR-Υ/NF-κB Pathway

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Rôle du récepteur purinergique P2X4 dans l'activation des myofibroblastes au cours de la fibrogenèse hépatique

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