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Tributylphosphate (TBP) and tris (2-butoxyethyl) phosphate (TBEP) induced apoptosis and cell cycle arrest in HepG2 cells

https://doi.org/10.1039/c7tx00180k
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/em.20486openalex-snapshot
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Polychlorinated biphenyl quinone induces mitochondrial‐mediated and caspase‐dependent apoptosis in HepG2 cells
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Effects of TDCPP or TPP on gene transcriptions and hormones of HPG axis, and their consequences on reproduction in adult zebrafish (Danio rerio)
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Multiple bio-analytical methods to reveal possible molecular mechanisms of developmental toxicity in zebrafish embryos/larvae exposed to tris(2-butoxyethyl) phosphate
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Bioconcentration, metabolism and neurotoxicity of the organophorous flame retardant 1,3-dichloro 2-propyl phosphate (TDCPP) to zebrafish
inferredcites →https://doi.org/10.1016/j.chemosphere.2012.03.067openalex-snapshot
Phosphorus flame retardants: Properties, production, environmental occurrence, toxicity and analysis
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Organophosphorus flame retardants (PFRs) in human breast milk from several Asian countries
inferredcites →https://doi.org/10.1016/j.chemosphere.2015.03.028openalex-snapshot
Chronic toxicity evaluation of the flame retardant tris (2-butoxyethyl) phosphate (TBOEP) using Daphnia magna transcriptomic response
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The “adaptive responses” of low concentrations of HBCD in L02 cells and the underlying molecular mechanisms
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inferredcites →https://doi.org/10.1016/j.chroma.2013.06.042openalex-snapshot
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inferredcites →https://doi.org/10.1016/j.ecoenv.2005.03.013openalex-snapshot
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inferredcites →https://doi.org/10.1016/j.envint.2010.11.007openalex-snapshot
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inferredcites →https://doi.org/10.1016/j.envpol.2015.10.045openalex-snapshot
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inferredcites →https://doi.org/10.1016/j.envpol.2016.03.050openalex-snapshot
Biological impact of environmental polycyclic aromatic hydrocarbons (ePAHs) as endocrine disruptors
inferredcites →https://doi.org/10.1016/j.envres.2011.01.015openalex-snapshot
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inferredcites →https://doi.org/10.1016/j.scitotenv.2013.06.088openalex-snapshot
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inferredcites →https://doi.org/10.1016/j.taap.2011.01.005openalex-snapshot
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inferredcites →https://doi.org/10.1016/j.taap.2015.01.021openalex-snapshot
In vitro biotransformation of tris(2-butoxyethyl) phosphate (TBOEP) in human liver and serum
inferredcites →https://doi.org/10.1016/j.toxlet.2014.03.023openalex-snapshot
Toxicity of TDCPP and TCEP on PC12 cell: Changes in CAMKII, GAP43, tubulin and NF-H gene and protein levels
inferredcites →https://doi.org/10.1016/j.toxlet.2015.02.001openalex-snapshot
Non-dioxin-like polychlorinated biphenyls (PCB 101, PCB 153 and PCB 180) induce chondrocyte cell death through multiple pathways
inferredcites →https://doi.org/10.1016/j.toxlet.2016.01.004openalex-snapshot
Effects of primary metabolites of organophosphate flame retardants on transcriptional activity via human nuclear receptors
inferredcites →https://doi.org/10.1016/j.trac.2008.07.002openalex-snapshot
Organophosphorus flame retardants and plasticizers in water and air I. Occurrence and fate
inferredcites →https://doi.org/10.1016/j.watres.2014.01.031openalex-snapshot
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inferredcites →https://doi.org/10.1016/s0045-6535(03)00666-0openalex-snapshot
Screening of organophosphorus compounds and their distribution in various indoor environments
inferredcites →https://doi.org/10.1016/s0300-9084(02)01368-8openalex-snapshot
Mitochondrial intermembrane junctional complexes and their involvement in cell death
inferredcites →https://doi.org/10.1021/acs.chemrestox.5b00320openalex-snapshot
Polychlorinated Biphenyl Quinone Metabolite Promotes p53-Dependent DNA Damage Checkpoint Activation, S-Phase Cycle Arrest and Extrinsic Apoptosis in Human Liver Hepatocellular Carcinoma HepG2 Cells
inferredcites →https://doi.org/10.1021/es051013lopenalex-snapshot
Organophosphorus Flame Retardants and Plasticizers in Swedish Sewage Treatment Plants
inferredcites →https://doi.org/10.1021/es303471dopenalex-snapshot
Novel and High Volume Use Flame Retardants in US Couches Reflective of the 2005 PentaBDE Phase Out
inferredcites →https://doi.org/10.1021/es401265qopenalex-snapshot
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inferredcites →https://doi.org/10.1021/ez400034nopenalex-snapshot
High Levels of Organophosphate Flame Retardants in the Great Lakes Atmosphere
inferredcites →https://doi.org/10.1038/nature01485openalex-snapshot
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inferredcites →https://doi.org/10.1038/sj.cdd.4401925openalex-snapshot
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Organophosphorus flame retardants and plasticizers in air from various indoor environments
inferredcites →https://doi.org/10.1039/b921910bopenalex-snapshot
Organophosphorus flame retardants and plasticizers in marine and fresh water biota and in human milk
inferredcites →https://doi.org/10.1046/j.1365-2184.2003.00266.xopenalex-snapshot
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inferredcites →https://doi.org/10.1080/109158100224926openalex-snapshot
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inferredcites →https://doi.org/10.1080/10934529.2016.1191819openalex-snapshot
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inferredcites →https://doi.org/10.1089/152308602760598891openalex-snapshot
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inferredcites →https://doi.org/10.1093/oxfordjournals.bmb.a011624openalex-snapshot
The bcl-2 family of proteins
inferredcites →https://doi.org/10.1093/toxsci/kft100openalex-snapshot
In Ovo Effects of Two Organophosphate Flame Retardants—TCPP and TDCPP—on Pipping Success, Development, mRNA Expression, and Thyroid Hormone Levels in Chicken Embryos
inferredcites →https://doi.org/10.1093/toxsci/kfw012openalex-snapshot
Organophosphate Flame Retardants Act as Endocrine-Disrupting Chemicals in MA-10 Mouse Tumor Leydig Cells
inferredcites →https://doi.org/10.1124/dmd.31.8.1035openalex-snapshot
COMPARISON OF PRIMARY HUMAN HEPATOCYTES AND HEPATOMA CELL LINE HEPG2 WITH REGARD TO THEIR BIOTRANSFORMATION PROPERTIES
inferredcites →https://doi.org/10.1177/1534735416637424openalex-snapshot
Antihepatocellular Carcinoma Potential of Tetramethylpyrazine Induces Cell Cycle Modulation and Mitochondrial-Dependent Apoptosis
inferredcites →https://doi.org/10.1289/ehp.01109s149openalex-snapshot
Polybrominated diphenyl ethers: occurrence, dietary exposure, and toxicology.

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.4685687openalex-extracted
Potential Adverse Outcome Pathway of Oxidative Stress Induction and Neurodevelopmental Toxicity Mediated by Three Alkyl Organophosphate Flame Retardants in Zebrafish Larvae
inferred← citeshttps://doi.org/10.1007/s13273-026-00661-3openalex-snapshot
A 96-h Cyprinus carpio-derived cell-based platform for cytotoxicity and genotoxicity screening of plasticizers
inferred← citeshttps://doi.org/10.1007/s13399-022-03441-wopenalex-snapshot
Tributyl phosphate degradation by Sphingobium sp. RSMS in large-scale stirred tank reactors
inferred← citeshttps://doi.org/10.1016/j.chemosphere.2019.03.130openalex-snapshot
The critical factors affecting typical organophosphate flame retardants to mimetic biomembrane: An integrated in vitro and in silico study
inferred← citeshttps://doi.org/10.1016/j.chemosphere.2022.133977openalex-snapshot
Tris(2-butoxyethyl) phosphate (TBEP): A flame retardant in solid waste display hepatotoxic and carcinogenic risks for humans
inferred← citeshttps://doi.org/10.1016/j.chemosphere.2024.141901openalex-snapshot
Potential adverse outcome pathway of neurodevelopmental toxicity, inflammatory response, and oxidative stress induction mediated by three alkyl organophosphate flame retardants in zebrafish larvae
inferred← citeshttps://doi.org/10.1016/j.ecoenv.2025.119325openalex-snapshot
Investigation of the gastric toxicity induced by exposure to tri-isobutyl phosphate
inferred← citeshttps://doi.org/10.1016/j.ecoenv.2026.120885openalex-snapshot
Tributyl phosphate induces liver aging via fumarate-mediated mitochondrial DNA escape triggered FPR2 activation
inferred← citeshttps://doi.org/10.1016/j.emcon.2020.08.004openalex-snapshot
A review of sources, fate, levels, toxicity, exposure and transformations of organophosphorus flame-retardants and plasticizers in the environment
inferred← citeshttps://doi.org/10.1016/j.envint.2022.107209openalex-snapshot
Alkyl organophosphate flame retardants (OPFRs) induce lung inflammation and aggravate OVA-simulated asthmatic response via the NF-кB signaling pathway
inferred← citeshttps://doi.org/10.1016/j.envint.2022.107260openalex-snapshot
Environmentally relevant concentrations of benzophenones triggered DNA damage and apoptosis in male Chinese rare minnows (Gobiocypris rarus)
inferred← citeshttps://doi.org/10.1016/j.envpol.2020.116245openalex-snapshot
Carbamazepine at environmentally relevant concentrations caused DNA damage and apoptosis in the liver of Chinese rare minnows (Gobiocypris rarus) by the Ras/Raf/ERK/p53 signaling pathway
inferred← citeshttps://doi.org/10.1016/j.envpol.2024.124800openalex-snapshot
The toxic effects and mechanisms of maternal exposure to Bisphenol F during gestation and lactation on lungs in female offspring mice
inferred← citeshttps://doi.org/10.1016/j.envres.2026.125835openalex-snapshot
Gestational exposure to organophosphate esters (OPEs) and adiposity during middle childhood in the MIREC Cohort
inferred← citeshttps://doi.org/10.1016/j.jhazmat.2024.133543openalex-snapshot
Global environmental and toxicological impacts of polybrominated diphenyl ethers versus organophosphate esters: A comparative analysis and regrettable substitution dilemma
inferred← citeshttps://doi.org/10.1016/j.jhazmat.2024.136066openalex-snapshot
Removal of TBP sorbed on wood by Trametes versicolor through solid-state fermentation
inferred← citeshttps://doi.org/10.1016/j.mrfmmm.2022.111776openalex-snapshot
Cell cycle involvement in cancer therapy; WEE1 kinase, a potential target as therapeutic strategy
inferred← citeshttps://doi.org/10.1016/j.scitotenv.2020.138526openalex-snapshot
Organophosphorus flame retardant TDCPP-induced cytotoxicity and associated mechanisms in normal human skin keratinocytes
inferred← citeshttps://doi.org/10.1016/j.scitotenv.2022.153160openalex-snapshot
Organophosphate flame retardants induce oxidative stress and Chop/Caspase 3-related apoptosis via Sod1/p53/Map3k6/Fkbp5 in NCI-1975 cells
inferred← citeshttps://doi.org/10.1016/j.scitotenv.2024.178260openalex-snapshot
Degradation of organophosphate flame retardants by white-rot fungi: Degradation pathways and associated toxicity
inferred← citeshttps://doi.org/10.1016/j.toxlet.2026.111847openalex-snapshot
Tributyl phosphate disrupts hepatic lipid metabolism via cGAS-STING signal pathway mediated inflammation
inferred← citeshttps://doi.org/10.1016/j.watres.2024.122262openalex-snapshot
Cytotoxicity evaluation of organophosphorus flame retardants using electrochemical biosensors and elucidation of associated toxic mechanisms
inferred← citeshttps://doi.org/10.1021/acs.est.0c00640openalex-snapshot
Comparison of the Toxicity Effects of Tris(1,3-dichloro-2-propyl)phosphate (TDCIPP) with Tributyl Phosphate (TNBP) Reveals the Mechanism of the Apoptosis Pathway in Asian Freshwater Clams (Corbicula fluminea)
inferred← citeshttps://doi.org/10.1021/acs.est.5c14462openalex-snapshot
Gestational Exposure to Tri- n -butyl Phosphate Induces Maternal Insulin Resistance and Glucose Intolerance by Antagonizing Estrogen Receptor Alpha
inferred← citeshttps://doi.org/10.1146/annurev-chembioeng-082323-120010openalex-snapshot
Beyond Phase Equilibria: Selecting Suitable Solvent Systems for Reactive Extraction of Carboxylic Acids
inferred← citeshttps://doi.org/10.2139/ssrn.4901415openalex-snapshot
Removal of Tbp Sorbed on Wood by Trametes Versicolor Through Solid-State Fermentation
inferred← citeshttps://doi.org/10.3390/ijms21124258openalex-snapshot
Organophosphorus Compounds and MAPK Signaling Pathways
inferred← citeshttps://doi.org/10.3390/ijms23073998openalex-snapshot
Cyto-Genotoxic and Transcriptomic Alterations in Human Liver Cells by Tris (2-Ethylhexyl) Phosphate (TEHP): A Putative Hepatocarcinogen
inferred← citeshttps://doi.org/10.3390/ijms251910705openalex-snapshot
ANKK1 Is a Wnt/PCP Scaffold Protein for Neural F-ACTIN Assembly
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