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Effects on longevity extension and mechanism of action of carnosic acid in Caenorhabditis elegans

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1007/bf02432519openalex-snapshot

Role of antioxidant nutrients in aging: Overview

inferredcites →https://doi.org/10.1007/s10522-008-9199-6openalex-snapshot

Quercetin mediated lifespan extension in Caenorhabditis elegans is modulated by age-1, daf-2, sek-1 and unc-43

inferredcites →https://doi.org/10.1007/s10522-011-9334-7openalex-snapshot

Hormetins, antioxidants and prooxidants: defining quercetin-, caffeic acid- and rosmarinic acid-mediated life extension in C. elegans

inferredcites →https://doi.org/10.1007/s11130-010-0166-4openalex-snapshot

Inhibitory Effects of Rosemary Extracts, Carnosic Acid and Rosmarinic Acid on the Growth of Various Human Cancer Cell Lines

inferredcites →https://doi.org/10.1016/j.bcp.2008.04.013openalex-snapshot

Carnosic acid and carnosol potently inhibit human 5-lipoxygenase and suppress pro-inflammatory responses of stimulated human polymorphonuclear leukocytes

inferredcites →https://doi.org/10.1016/j.cell.2008.01.030openalex-snapshot

Direct Inhibition of the Longevity-Promoting Factor SKN-1 by Insulin-like Signaling in C. elegans

inferredcites →https://doi.org/10.1016/j.cell.2013.05.039openalex-snapshot

The Hallmarks of Aging

inferredcites →https://doi.org/10.1016/j.cub.2005.12.038openalex-snapshot

Resveratrol Prolongs Lifespan and Retards the Onset of Age-Related Markers in a Short-Lived Vertebrate

inferredcites →https://doi.org/10.1016/j.cub.2007.08.047openalex-snapshot

An AMPK-FOXO Pathway Mediates Longevity Induced by a Novel Method of Dietary Restriction in C. elegans

inferredcites →https://doi.org/10.1016/j.mad.2003.10.002openalex-snapshot

Coenzyme Q10 can prolong C. elegans lifespan by lowering oxidative stress

inferredcites →https://doi.org/10.1016/j.meatsci.2004.07.010openalex-snapshot

Comparison of a natural rosemary extract and BHA/BHT for relative antioxidant effectiveness in pork sausage

inferredcites →https://doi.org/10.1016/j.meatsci.2006.07.018openalex-snapshot

Effect of rosemary extract, chitosan and α-tocopherol on lipid oxidation and colour stability during frozen storage of beef burgers

inferredcites →https://doi.org/10.1016/j.mimet.2010.02.004openalex-snapshot

Evaluation of diffusion and dilution methods to determine the antibacterial activity of plant extracts

inferredcites →https://doi.org/10.1016/j.neuropharm.2016.04.017openalex-snapshot

Carnosic acid protects SH-SY5Y cells against 6-hydroxydopamine-induced cell death through upregulation of parkin pathway

inferredcites →https://doi.org/10.1016/j.tox.2007.02.006openalex-snapshot

Investigations of protective effects of the flavonoids quercetin and rutin on stress resistance in the model organism Caenorhabditis elegans

inferredcites →https://doi.org/10.1016/s0021-9673(03)00487-4openalex-snapshot

Quantitative determination of phenolic diterpenes in rosemary extracts

inferredcites →https://doi.org/10.1016/s0092-8674(03)00889-4openalex-snapshot

Tissue-Specific Activities of C. elegans DAF-16 in the Regulation of Lifespan

inferredcites →https://doi.org/10.1016/s0167-7799(01)01925-4openalex-snapshot

The worm in us – Caenorhabditis elegans as a model of human disease

inferredcites →https://doi.org/10.1016/s0197-4580(02)00224-5openalex-snapshot

Gene expression analysis in a transgenic Caenorhabditis elegans Alzheimer's disease model

inferredcites →https://doi.org/10.1021/acs.jafc.5b01246openalex-snapshot

Carnosic Acid as a Major Bioactive Component in Rosemary Extract Ameliorates High-Fat-Diet-Induced Obesity and Metabolic Syndrome in Mice

inferredcites →https://doi.org/10.1021/acs.jafc.6b02183openalex-snapshot

Inhibition of Fat Accumulation by Hesperidin in Caenorhabditis elegans

inferredcites →https://doi.org/10.1021/jf500210popenalex-snapshot

Mechanism of Longevity Extension ofCaenorhabditis elegansInduced by Pentagalloyl Glucose Isolated from Eucalyptus Leaves

inferredcites →https://doi.org/10.1038/nature01135openalex-snapshot

Stochastic and genetic factors influence tissue-specific decline in ageing C. elegans

inferredcites →https://doi.org/10.1038/nature16483openalex-snapshot

The C. elegans adult neuronal IIS/FOXO transcriptome reveals adult phenotype regulators

inferredcites →https://doi.org/10.1046/j.1365-2540.2000.0745d.xopenalex-snapshot

C. elegans: A Practical Approach. Ian A. Hope (ed.). Oxford University Press, Oxford. 1999. Pp. 281. Price £29.95, paperback. ISBN 0 19 963738 5.

inferredcites →https://doi.org/10.1073/pnas.152161099openalex-snapshot

The threshold for polyglutamine-expansion protein aggregation and cellular toxicity is dynamic and influenced by aging in Caenorhabditis elegans

inferredcites →https://doi.org/10.1073/pnas.92.16.7540openalex-snapshot

Thermotolerance and extended life-span conferred by single-gene mutations and induced by thermal stress.

inferredcites →https://doi.org/10.1093/ajcn/81.1.313sopenalex-snapshot

Reversing the deleterious effects of aging on neuronal communication and behavior: beneficial properties of fruit polyphenolic compounds

inferredcites →https://doi.org/10.1093/geronj/11.3.298openalex-snapshot

Aging: A Theory Based on Free Radical and Radiation Chemistry

inferredcites →https://doi.org/10.1101/gad.1324805openalex-snapshot

The C. elegans p38 MAPK pathway regulates nuclear localization of the transcription factor SKN-1 in oxidative stress response

inferredcites →https://doi.org/10.1111/acel.12431openalex-snapshot

Effects and mechanisms of prolongevity induced by Lactobacillus gasseri SBT2055 in Caenorhabditis elegans

inferredcites →https://doi.org/10.1111/j.1474-9726.2005.00153.xopenalex-snapshot

In vivospectrofluorimetry reveals endogenous biomarkers that report healthspan and dietary restriction inCaenorhabditis elegans

inferredcites →https://doi.org/10.1111/j.1474-9726.2006.00188.xopenalex-snapshot

Studies of Caenorhabditis elegans DAF‐2/insulin signaling reveal targets for pharmacological manipulation of lifespan

inferredcites →https://doi.org/10.1111/j.1474-9726.2006.00192.xopenalex-snapshot

Blueberry polyphenols increase lifespan and thermotolerance in Caenorhabditis elegans

inferredcites →https://doi.org/10.1111/j.1872-034x.2010.00747.xopenalex-snapshot

Carnosic acid prevents obesity and hepatic steatosis in ob/ob mice

inferredcites →https://doi.org/10.1126/science.1073759openalex-snapshot

A Conserved p38 MAP Kinase Pathway in Caenorhabditis elegans Innate Immunity

inferredcites →https://doi.org/10.1126/science.1083614openalex-snapshot

DAF-16 Target Genes That Control C. elegans Life-Span and Metabolism

inferredcites →https://doi.org/10.1126/science.1083701openalex-snapshot

Regulation of Aging and Age-Related Disease by DAF-16 and Heat-Shock Factor

inferredcites →https://doi.org/10.1371/journal.pone.0008758openalex-snapshot

Metformin Induces a Dietary Restriction–Like State and the Oxidative Stress Response to Extend C. elegans Healthspan via AMPK, LKB1, and SKN-1

inferredcites →https://doi.org/10.1371/journal.pone.0028835openalex-snapshot

Icariin and its Derivative Icariside II Extend Healthspan via Insulin/IGF-1 Pathway in C. elegans

inferredcites →https://doi.org/10.1371/journal.pone.0056877openalex-snapshot

Drug Absorption Efficiency in Caenorhbditis elegans Delivered by Different Methods

inferredcites →https://doi.org/10.2174/1381612824666180515145652openalex-snapshot

Anti-aging and Anti-aggregation Properties of Polyphenolic Compounds in C. elegans

inferredcites →https://doi.org/10.4196/kjpp.2016.20.1.15openalex-snapshot

Carnosic acid protects against acetaminophen-induced hepatotoxicity by potentiating Nrf2-mediated antioxidant capacity in mice

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.4777555openalex-extracted

Selective Extraction, Using Supercritical Fluid, of Carnosic Acid, Carnosol and Acid Rosmarinic from Rosmarinus Officinalis and Their Antioxidant Activity

inferred← citeshttps://doi.org/10.1002/biof.1536openalex-snapshot

Rosmarinic acid improved antioxidant properties and healthspan via the IIS and MAPK pathways in Caenorhabditis elegans

inferred← citeshttps://doi.org/10.1002/fsn3.71427openalex-snapshot

The Antioxidant and Antiaging Properties of Maillard Reaction Products Derived From Dipeptide Lys–Leu in Caenorhabditis elegans

inferred← citeshttps://doi.org/10.1002/jsfa.12063openalex-snapshot

DAF ‐16 is involved in colonic metabolites of ferulic acid‐promoted longevity and stress resistance of Caenorhabditis elegans

inferred← citeshttps://doi.org/10.1002/jsfa.70730openalex-snapshot

ACE ‐inhibitory peptide Leu‐Tyr‐Ala in skeletal muscle actin exhibits anti‐aging effects through the inhibition of acn‐1 in Caenorhabditis elegans

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Synthesizing UPLC-Q-Exactive Orbitrap/MS analysis, network pharmacology, and in vivo experimental to screen candidate components and targets of Rosa roxburghii Tratt seed for anti-aging

inferred← citeshttps://doi.org/10.1007/s00394-020-02338-6openalex-snapshot

Antistress and anti-aging activities of Caenorhabditis elegans were enhanced by Momordica saponin extract

inferred← citeshttps://doi.org/10.1007/s10522-022-09956-zopenalex-snapshot

Ginseng volatile oil prolongs the lifespan and healthspan of Caenorhabditis elegans

inferred← citeshttps://doi.org/10.1007/s10522-023-10030-5openalex-snapshot

Dauer larva-derived extracellular vesicles extend the life of Caenorhabditis elegans

inferred← citeshttps://doi.org/10.1007/s10522-025-10355-3openalex-snapshot

Potential dietary geroprotectors and their impact on key mechanisms of aging

inferred← citeshttps://doi.org/10.1007/s10522-026-10418-zopenalex-snapshot

Cycloneolitsol prolongs the lifespan of Caenorhabditis elegans by SEK-1/PMK-1/SKN-1 pathway and exerts anti-inflammatory effects by NF-κB pathway

inferred← citeshttps://doi.org/10.1007/s11130-023-01059-5openalex-snapshot

A Novel Polysaccharide DSPP-1 from Durian Seed: Structure Characterization and Its Protective Effects Against Alzheimer’s Disease in a Transgenic Caenorhabditis elegans Model

inferred← citeshttps://doi.org/10.1007/s11694-019-00211-7openalex-snapshot

Comprehensive determination of seven polyphenols in Eucommia ulmoides and its anti-oxidative stress activity in C. elegans

inferred← citeshttps://doi.org/10.1007/s11694-020-00653-4openalex-snapshot

Saponins extracted by ultrasound from Zizyphus jujuba Mil var. spinosa leaves exert resistance to oxidative damage in Caenorhabditis elegans

inferred← citeshttps://doi.org/10.1007/s12602-025-10662-8openalex-snapshot

Enterococcus Durans J396 Isolated from the Intestine of a Pig Enhances the Antioxidant Activity in Caenorhabditis Elegans

inferred← citeshttps://doi.org/10.1016/b978-0-443-31698-2.00015-1openalex-snapshot

Targeting molecular chaperones with phytochemicals for drug discovery in metabolic ailment

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Hormesis determines lifespan

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The unfolded protein response pathway mediates ovalbumin-induced innate immune response in Caenorhabditis elegans

inferred← citeshttps://doi.org/10.1016/j.biopha.2023.115594openalex-snapshot

Caenorhabditis elegans as an in vivo model for the identification of natural antioxidants with anti-aging actions

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Characterization of GABA-loaded nanoliposomes and its health benefits

inferred← citeshttps://doi.org/10.1016/j.exger.2023.112131openalex-snapshot

Zhuyeqing liquor promotes longevity through enhancing stress resistance via regulation of SKN-1 and HSF-1 transcription factors in Caenorhabditis elegans

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Integrating network pharmacology and transcriptomics reveals that bound polyphenols from defatted rice bran insoluble dietary fiber delays senescence in C. elegans through modulating IIS pathway

inferred← citeshttps://doi.org/10.1016/j.fitote.2025.106441openalex-snapshot

The anti-aging and anti-Alzheimer's disease potential of kinsenoside prepared from Anoectochilus roxburghii

inferred← citeshttps://doi.org/10.1016/j.fochx.2023.100836openalex-snapshot

Antioxidant characteristics of hydrolysate from low-value sea cucumber: In vitro and in vivo activities of Caenorhabditis elegans

inferred← citeshttps://doi.org/10.1016/j.foodchem.2022.133667openalex-snapshot

Advances on Cyclocarya paliurus polyphenols: Extraction, structures, bioactivities and future perspectives

inferred← citeshttps://doi.org/10.1016/j.foodhyd.2020.106114openalex-snapshot

Facile synthesis of nano-nanocarriers from chitosan and pectin with improved stability and biocompatibility for anthocyanins delivery: An in vitro and in vivo study

inferred← citeshttps://doi.org/10.1016/j.foodres.2025.117215openalex-snapshot

Polysaccharide from Ganoderma atrum delay senescence and enhance stress resistance through modulating IIS and MAPK pathway in Caenorhabditis elegans

inferred← citeshttps://doi.org/10.1016/j.ijbiomac.2019.12.023openalex-snapshot

Polysaccharide extracted from the leaves of Cyclocarya paliurus (Batal.) Iljinskaja enhanced stress resistance in Caenorhabditis elegans via skn-1 and hsf-1

inferred← citeshttps://doi.org/10.1016/j.ijbiomac.2024.132833openalex-snapshot

Unlocking the potential of chicken liver byproducts: Identification of antioxidant peptides through in silico approaches and anti-aging effects of a selected peptide in Caenorhabditis elegans

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Impact of copper(II) complexes on increase in lifespan and mean survival of gld-1 mutant strain JK1466 in Caenorhabditis elegans

inferred← citeshttps://doi.org/10.1016/j.jff.2025.106992openalex-snapshot

Heat-inactivated Bifidobacterium longum ZFML006 extends lifespan in Caenorhabditis elegans via MAPK and insulin/IGF-1 signaling pathways

inferred← citeshttps://doi.org/10.1016/j.jfutfo.2025.05.024openalex-snapshot

Chronic consumption of oxidatively modified rice bran protein accelerates aging process in C. elegans by suppressing DAF-16 and SKN-1 pathways

inferred← citeshttps://doi.org/10.1016/j.phanu.2020.100233openalex-snapshot

Rosemary extract modulates stress resistance and accumulation of reactive oxygen species in the model organism Caenorhabditis elegans

inferred← citeshttps://doi.org/10.1016/j.phrs.2021.105697openalex-snapshot

Saponins isolated from Radix polygalae extent lifespan by modulating complement C3 and gut microbiota

inferred← citeshttps://doi.org/10.1016/j.procbio.2024.09.021openalex-snapshot

Pentagalloyl glucose enhanced the stress resistance to delay aging process in Caenorhabditis elegans

inferred← citeshttps://doi.org/10.1016/j.supflu.2024.106344openalex-snapshot

Selective extraction of carnosic acid, carnosol, and rosmarinic acid from Rosmarinus officinalis L. using supercritical fluid and their antioxidant activity

inferred← citeshttps://doi.org/10.1021/acs.jafc.5c05084openalex-snapshot

L-Quebrachitol from Sea Buckthorn Leaves Extends Lifespan by Regulating Antioxidant Activity and Autophagy through AMP-Activated Protein Kinase/SIR-2.1/DAF-16 and IIS Signaling Pathways

inferred← citeshttps://doi.org/10.1039/c9fo00254eopenalex-snapshot

Effects of Momordica saponin extract on alleviating fat accumulation in Caenorhabditis elegans

inferred← citeshttps://doi.org/10.1039/c9fo02472gopenalex-snapshot

Healthy lifespan extension mediated by oenothein B isolated from Eucalyptus grandis × Eucalyptus urophylla GL9 in Caenorhabditis elegans

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Anti-fat effect and mechanism of polysaccharide-enriched extract from Cyclocarya paliurus (Batal.) Iljinskaja in Caenorhabditis elegans

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Oxyresveratrol extracted from Artocarpus heterophyllus Lam. inhibits tyrosinase and age pigments in vitro and in vivo

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Caffeic acid protects against Aβ toxicity and prolongs lifespan in Caenorhabditis elegans models

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HSF-1 and SIR-2.1 linked insulin-like signaling is involved in goji berry ( Lycium spp.) extracts promoting lifespan extension of Caenorhabditis elegans

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DAF-16 acts as the “hub” of astaxanthin's anti-aging mechanism to improve aging-related physiological functions in Caenorhabditis elegans

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Carnosic acid ameliorated Aβ-mediated (amyloid-β peptide) toxicity, cholinergic dysfunction and mitochondrial defect in Caenorhabditis elegans of Alzheimer's Model

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A novel peptide derived from Haematococcus pluvialis residue exhibits anti-aging activity in Caenorhabditis elegans via the insulin/IGF-1 signaling pathway

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Latilactobacillus curvatus FFZZH5L isolated from pickled cowpea enhanced antioxidant activity in Caenorhabditis elegans by upregulating the level of glutathione S -transferase

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Physiological evaluation and transcriptomic and proteomic analyses to reveal the anti-aging and reproduction-promoting mechanisms of glycitein in Caenorhabditis elegans

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Sake lees extract obtained using a novel continuous phase-transition extraction method: evaluation of its bioactive composition, anti-aging efficacy and mechanism

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Mitophagy-promoting agents and their ability to promote healthy-aging

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Therapeutic Potential of Carnosic Acid in Alopecia: A Mechanistic Perspective

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Potential of Caenorhabditis elegans as an antiaging evaluation model for dietary phytochemicals: A review

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The Study of Association of Polymorphic Markers of the SOD1, SOD2, and SOD3 Genes with Longevity

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Carnosol Improved Lifespan and Healthspan by Promoting Antioxidant Capacity in Caenorhabditis elegans

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Healthspan Improvements in Caenorhabditis elegans with Traditional Chinese Herbal Tea

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A Dihydroflavonoid Naringin Extends the Lifespan of C . elegans and Delays the Progression of Aging-Related Diseases in PD/AD Models via DAF-16

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Plant and fungal products that extend lifespan in Caenorhabditis elegans

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Rosmarinic acid regulates lipid accumulation through lipid metabolism and anti-inflammatory

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Streblus asper Lour. exerts MAPK and SKN-1 mediated anti-aging, anti-photoaging activities and imparts neuroprotection by ameliorating Aβ in Caenorhabditis elegans

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Identification of Flavoanoids From Finger Citron and Evaluation on Their Antioxidative and Antiaging Activities

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Litchi flower essential oil balanced lipid metabolism through the regulation of DAF-2/IIS, MDT-15/SBP-1, and MDT-15/NHR-49 pathway

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Enhanced Healthspan in Caenorhabditis elegans Treated With Extracts From the Traditional Chinese Medicine Plants Cuscuta chinensis Lam. and Eucommia ulmoides Oliv.

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The endophytic fungus Penicillium oxalicum isolated from Ligusticum chuanxiong Hort possesses DNA damage-protecting potential and increases stress resistance properties in Caenorhabditis elegans

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Inhibition of MurA Enzyme from Escherichia coli and Staphylococcus aureus by Diterpenes from Lepechinia meyenii and Their Synthetic Analogs

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Red Cabbage Rather Than Green Cabbage Increases Stress Resistance and Extends the Lifespan of Caenorhabditis elegans

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Oleuropein Enhances Stress Resistance and Extends Lifespan via Insulin/IGF-1 and SKN-1/Nrf2 Signaling Pathway in Caenorhabditis elegans

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Multi-Target Effects of ß-Caryophyllene and Carnosic Acid at the Crossroads of Mitochondrial Dysfunction and Neurodegeneration: From Oxidative Stress to Microglia-Mediated Neuroinflammation

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Effects of Bacillus cereus on Survival, Fecundity, and Host Adaptability of Pine Wood Nematode

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A Deep Insight in the Antioxidant Property of Carnosic Acid: From Computational Study to Experimental Analysis

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Nobiletin Delays Aging and Enhances Stress Resistance of Caenorhabditis elegans

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Ferulic Acid Supplementation Increases Lifespan and Stress Resistance via Insulin/IGF-1 Signaling Pathway in C. elegans

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Hesperetin Increases Lifespan and Antioxidant Ability Correlating with IIS, HSP, mtUPR, and JNK Pathways of Chronic Oxidative Stress in Caenorhabditis elegans

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Effects of Orange Extracts on Longevity, Healthspan, and Stress Resistance in Caenorhabditis elegans

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Bioactive Phytochemicals with Anti-Aging and Lifespan Extending Potentials in Caenorhabditis elegans

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Cornus officinalis Extract Enriched with Ursolic Acid Ameliorates UVB-Induced Photoaging in Caenorhabditis elegans

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Grifola frondosa (Maitake) Extract Reduces Fat Accumulation and Improves Health Span in C. elegans through the DAF-16/FOXO and SKN-1/NRF2 Signalling Pathways

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Ballodiolic Acid A and B: Two New ROS, (•OH), (ONOO−) Scavenging and Potent Antimicrobial Constituents Isolated from Ballota pseudodictamnus (L.) Benth.

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Éco-extraction des molécules bioactives du Rosmarinus officinalis L de la région orientale du Maroc : application des approches prédictives et optimisation de l’extraction sélective au CO₂ supercritique

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