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Medicinal chemistry updates on quinoline- and endoperoxide-based hybrids with potent antimalarial activity

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/anie.201907224openalex-snapshot
Artemisinin–(Iso)quinoline Hybrids by C−H Activation and Click Chemistry: Combating Multidrug‐Resistant Malaria
inferredcites →https://doi.org/10.1002/cbic.200400347openalex-snapshot
Design, Synthesis and Antimalarial Activity of Trifluoromethylartemisinin–Mefloquine Dual Molecules
inferredcites →https://doi.org/10.1002/cmdc.201200536openalex-snapshot
Artemisinin–Polypyrrole Conjugates: Synthesis, DNA Binding Studies and Preliminary Antiproliferative Evaluation
inferredcites →https://doi.org/10.1002/cmdc.201800728openalex-snapshot
Targeting Asexual and Sexual Blood Stages of the Human Malaria Parasite P. falciparum with 7‐Chloroquinoline‐Based 1,2,3‐Triazoles
inferredcites →https://doi.org/10.1002/ddr.20345openalex-snapshot
Next‐generation antimalarial drugs: hybrid molecules as a new strategy in drug design
inferredcites →https://doi.org/10.1002/jhet.3617openalex-snapshot
Design, Synthesis, and Biological andIn SilicoStudy of Fluorine‐Containing Quinoline Hybrid Thiosemicarbazide Analogues
inferredcites →https://doi.org/10.1002/jhet.3855openalex-snapshot
Synthesis of novel quinoline‐thiosemicarbazide hybrids and evaluation of their biological activities, molecular docking, molecular dynamics, pharmacophore model studies, and ADME‐Tox properties
inferredcites →https://doi.org/10.1002/med.21643openalex-snapshot
Hybrid molecules with potential in vitro antiplasmodial and in vivo antimalarial activity against drug‐resistant Plasmodium falciparum
inferredcites →https://doi.org/10.1007/978-1-59259-111-4_10openalex-snapshot
Artemisinin and Its Derivatives
inferredcites →https://doi.org/10.1016/j.bioorg.2020.104142openalex-snapshot
Identification and structure–activity relationship (SAR) studies of carvacrol derivatives as potential anti-malarial against Plasmodium falciparum falcipain-2 protease
inferredcites →https://doi.org/10.1016/j.bmc.2011.06.025openalex-snapshot
Synthesis and antimalarial activity of new heterocyclic hybrids based on chloroquine and thiazolidinone scaffolds
inferredcites →https://doi.org/10.1016/j.bmc.2015.04.017openalex-snapshot
From hybrid compounds to targeted drug delivery in antimalarial therapy
inferredcites →https://doi.org/10.1016/j.bmc.2015.06.056openalex-snapshot
Anti-Plasmodium falciparum activity of quinoline–sulfonamide hybrids
inferredcites →https://doi.org/10.1016/j.bmc.2016.05.060openalex-snapshot
Synthesis, antimalarial properties and 2D-QSAR studies of novel triazole-quinine conjugates
inferredcites →https://doi.org/10.1016/j.bmc.2019.01.044openalex-snapshot
New hybrid trifluoromethylquinolines as antiplasmodium agents
inferredcites →https://doi.org/10.1016/j.bmcl.2007.04.054openalex-snapshot
A novel artemisinin–quinine hybrid with potent antimalarial activity
inferredcites →https://doi.org/10.1016/j.bmcl.2008.11.047openalex-snapshot
Chloroquine–astemizole hybrids with potent in vitro and in vivo antiplasmodial activity
inferredcites →https://doi.org/10.1016/j.bmcl.2009.02.013openalex-snapshot
Semi-synthetic and synthetic 1,2,4-trioxaquines and 1,2,4-trioxolaquines: synthesis, preliminary SAR and comparison with acridine endoperoxide conjugates
inferredcites →https://doi.org/10.1016/j.bmcl.2009.10.010openalex-snapshot
Synthesis of 9-anilinoacridine triazines as new class of hybrid antimalarial agents
inferredcites →https://doi.org/10.1016/j.bmcl.2011.01.103openalex-snapshot
Synthesis, in vitro antimalarial and cytotoxicity of artemisinin-aminoquinoline hybrids
inferredcites →https://doi.org/10.1016/j.bmcl.2015.04.014openalex-snapshot
New quinoline derivatives demonstrate a promising antimalarial activity against Plasmodium falciparum in vitro and Plasmodium berghei in vivo
inferredcites →https://doi.org/10.1016/j.bmcl.2018.08.037openalex-snapshot
Synthesis, antimalarial activities and cytotoxicities of amino-artemisinin-1,2-disubstituted ferrocene hybrids
inferredcites →https://doi.org/10.1016/j.ejmech.2010.04.011openalex-snapshot
Quinolines and structurally related heterocycles as antimalarials
inferredcites →https://doi.org/10.1016/j.ejmech.2010.12.003openalex-snapshot
4-Anilinoquinoline triazines: A novel class of hybrid antimalarial agents
inferredcites →https://doi.org/10.1016/j.ejmech.2012.01.039openalex-snapshot
Novel hybrid molecules based on 15-membered azalide as potential antimalarial agents
inferredcites →https://doi.org/10.1016/j.ejmech.2014.07.064openalex-snapshot
β-amino-alcohol tethered 4-aminoquinoline-isatin conjugates: Synthesis and antimalarial evaluation
inferredcites →https://doi.org/10.1016/j.ejmech.2016.11.057openalex-snapshot
Design, synthesis and evaluation of 4-aminoquinoline-purine hybrids as potential antiplasmodial agents
inferredcites →https://doi.org/10.1016/j.ejmech.2017.07.061openalex-snapshot
Quinoline hybrids and their antiplasmodial and antimalarial activities
inferredcites →https://doi.org/10.1016/j.ejmech.2018.11.021openalex-snapshot
N-Substituted aminoquinoline-pyrimidine hybrids: Synthesis, in vitro antimalarial activity evaluation and docking studies
inferredcites →https://doi.org/10.1016/j.ejmech.2018.12.007openalex-snapshot
Current scenario of artemisinin and its analogues for antimalarial activity
inferredcites →https://doi.org/10.1016/j.ejmech.2020.112330openalex-snapshot
Synthesis and biological evaluation of novel quinoline-piperidine scaffolds as antiplasmodium agents
inferredcites →https://doi.org/10.1016/j.ejps.2014.01.014openalex-snapshot
Synthesis and in vitro biological evaluation of aminoacridines and artemisinin–acridine hybrids
inferredcites →https://doi.org/10.1016/j.exppara.2016.01.010openalex-snapshot
Design, synthesis and antimalarial screening of some hybrid 4-aminoquinoline-triazine derivatives against pf-DHFR-TS
inferredcites →https://doi.org/10.1016/j.idc.2018.10.002openalex-snapshot
Malaria
inferredcites →https://doi.org/10.1016/j.ijmm.2013.07.005openalex-snapshot
A primaquine–chloroquine hybrid with dual activity against Plasmodium liver and blood stages
inferredcites →https://doi.org/10.1016/j.pt.2019.05.002openalex-snapshot
Ozonide Antimalarial Activity in the Context of Artemisinin-Resistant Malaria
inferredcites →https://doi.org/10.1016/s2214-109x(17)30333-9openalex-snapshot
Outbreak of human malaria caused by Plasmodium simium in the Atlantic Forest in Rio de Janeiro: a molecular epidemiological investigation
inferredcites →https://doi.org/10.1021/acsmedchemlett.0c00196openalex-snapshot
Synthesis of Novel Ciprofloxacin-Based Hybrid Molecules toward Potent Antimalarial Activity
inferredcites →https://doi.org/10.1021/acsmedchemlett.8b00381openalex-snapshot
Synthesis of Artemisinin–Estrogen Hybrids Highly Active against HCMV, P. falciparum, and Cervical and Breast Cancer
inferredcites →https://doi.org/10.1021/acsmedchemlett.9b00669openalex-snapshot
Synthesis of Novel G Factor or Chloroquine-Artemisinin Hybrids and Conjugates with Potent Antiplasmodial Activity
inferredcites →https://doi.org/10.1021/acsomega.7b00310openalex-snapshot
Synthesis of Novel Hybrids of Quinazoline and Artemisinin with High Activities against Plasmodium falciparum , Human Cytomegalovirus, and Leukemia Cells
inferredcites →https://doi.org/10.1021/jm100117eopenalex-snapshot
Trioxaferroquines as New Hybrid Antimalarial Drugs
inferredcites →https://doi.org/10.1021/jm1009567openalex-snapshot
Endoperoxide Carbonyl Falcipain 2/3 Inhibitor Hybrids: Toward Combination Chemotherapy of Malaria through a Single Chemical Entity
inferredcites →https://doi.org/10.1021/jm4014778openalex-snapshot
Quinoline–Pyrimidine Hybrids: Synthesis, Antiplasmodial Activity, SAR, and Mode of Action Studies
inferredcites →https://doi.org/10.1038/nrmicro2239openalex-snapshot
Artemisinin-based combination therapies: a vital tool in efforts to eliminate malaria
inferredcites →https://doi.org/10.1038/s41598-018-36493-yopenalex-snapshot
Genetically diverse Plasmodium falciparum infections, within-host competition and symptomatic malaria in humans
inferredcites →https://doi.org/10.1038/s41598-019-42495-1openalex-snapshot
Electrical percolation threshold of carbon black in a polymer matrix and its application to antistatic fibre
inferredcites →https://doi.org/10.1039/c1md00188dopenalex-snapshot
Synthesis of hybrid 4-anilinoquinoline triazines as potent antimalarial agents, their in silico modeling and bioevaluation as Plasmodium falciparumtransketolase and β-hematin inhibitors
inferredcites →https://doi.org/10.1039/c5ra19673fopenalex-snapshot
A structure guided drug-discovery approach towards identification of Plasmodium inhibitors
inferredcites →https://doi.org/10.1039/c6ra00846aopenalex-snapshot
N-(7-Chloroquinolinyl-4-aminoalkyl)arylsulfonamides as antimalarial agents: rationale for the activity with reference to inhibition of hemozoin formation
inferredcites →https://doi.org/10.1073/pnas.0804338105openalex-snapshot
Selection of a trioxaquine as an antimalarial drug candidate
inferredcites →https://doi.org/10.1111/cbdd.12108openalex-snapshot
4‐Aminoquinoline‐Triazine‐Based Hybrids with Improved In Vitro Antimalarial Activity Against CQ ‐Sensitive and CQ ‐Resistant Strains of P lasmodium falciparum
inferredcites →https://doi.org/10.1128/aac.00249-17openalex-snapshot
Are Antimalarial Hybrid Molecules a Close Reality or a Distant Dream?
inferredcites →https://doi.org/10.1128/aac.05133-11openalex-snapshot
Design and Evaluation of Primaquine-Artemisinin Hybrids as a Multistage Antimalarial Strategy
inferredcites →https://doi.org/10.1186/1475-2875-10-144openalex-snapshot
Quinine, an old anti-malarial drug in a modern world: role in the treatment of malaria
inferredcites →https://doi.org/10.1186/1475-2875-12-71openalex-snapshot
Potent in vivo anti-malarial activity and representative snapshot pharmacokinetic evaluation of artemisinin-quinoline hybrids
inferredcites →https://doi.org/10.1186/s12936-019-2724-zopenalex-snapshot
The past, present and future of anti-malarial medicines
inferredcites →https://doi.org/10.17179/excli2016-677openalex-snapshot
Synthesis and antimalarial potential of some novel quinoline-pyrazolopyridine derivatives
inferredcites →https://doi.org/10.2174/1568026620666200130162347openalex-snapshot
Inhibition of Hemoglobin Degrading Protease Falcipain-2 as a Mechanism for Anti-Malarial Activity of Triazole-Amino Acid Hybrids
inferredcites →https://doi.org/10.3390/molecules21121629openalex-snapshot
Design, Synthesis and Biological Evaluation of Novel Primaquine-Cinnamic Acid Conjugates of the Amide and Acylsemicarbazide Type
inferredcites →https://doi.org/10.3390/molecules22122268openalex-snapshot
Quinoline-Based Hybrid Compounds with Antimalarial Activity
inferredcites →https://doi.org/10.3390/tropicalmed4010026openalex-snapshot
Resistance to Artemisinin Combination Therapies (ACTs): Do Not Forget the Partner Drug!
inferredcites →https://doi.org/10.3390/tropicalmed4040139openalex-snapshot
Strengthening Surveillance Systems for Malaria Elimination by Integrating Molecular and Genomic Data
inferredcites →https://doi.org/10.4155/fmc-2018-0337openalex-snapshot
Artemisinin and Its Derivatives; Ancient Tradition Inspiring the Latest Therapeutic Approaches Against Malaria

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.4675637openalex-extracted
Design, Synthesis and Anticancer Activity of New Quinolines, Quinazolines and 1,2,4-Triazoles with Pyrido[2,3-d] Pyrimidines
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An Efficient Approach for the Synthesis and Antitumor Evaluation of Novel Azo‐ and Anil‐Linked with 3‐Aminopyrazolo[3,4‐b]pyridine
inferred← citeshttps://doi.org/10.1002/cctc.202500620openalex-snapshot
A Multicomponent Synthetic Strategy for 2‐Pyrazolines and Pyrimidines Through Activation of Renewable Alcohols by a Versatile Fe(III) Catalyst and Friedländer Quinoline Synthesis
inferred← citeshttps://doi.org/10.1002/jccs.202300212openalex-snapshot
Synthesis, design, and antimicrobial activity of pyrido[2,3‐d][1,2,4]triazolo[4,3‐a]pyrimidinones based on quinoline derivatives
inferred← citeshttps://doi.org/10.1002/med.21979openalex-snapshot
An overview on the antimalarial activity of 1,2,4‐trioxanes, 1,2,4‐trioxolanes and 1,2,4,5‐tetraoxanes
inferred← citeshttps://doi.org/10.1002/slct.202504720openalex-snapshot
Targeting Plasmodium Falciparum Asexual and Sexual Stages with Melatonin‐Based Indole Compounds
inferred← citeshttps://doi.org/10.1007/s00044-022-02866-2openalex-snapshot
Design, synthesis and biological evaluation of 8-aminoquinoline-1,2,3-triazole hybrid derivatives as potential antimicrobial agents
inferred← citeshttps://doi.org/10.1007/s11030-024-11013-5openalex-snapshot
Fe3O4@SiO2@[Aminoglycol][Formate] as a new superparamagnetic nanocatalyst and [Aminoglycol][Formate] as a novel ionic liquid catalyst for preparation of new dimethyldihydropyrimido[4,5-b]quinolone derivatives
inferred← citeshttps://doi.org/10.1007/s11696-026-05605-8openalex-snapshot
In-vitro and in-silico evaluation of interactions between Camellia sinensis leaf extract and selected 4-aminoquinoline antimalarial drugs
inferred← citeshttps://doi.org/10.1007/s44371-025-00339-0openalex-snapshot
Deciphering the inhibitory activity of flavonoids against Plasmodium falciparum proteases through molecular docking, drug-likeness and pharmacokinetic studies
inferred← citeshttps://doi.org/10.1016/j.bmcl.2024.129992openalex-snapshot
Pyridine and Pyrimidine hybrids as privileged scaffolds in antimalarial drug discovery: A recent development
inferred← citeshttps://doi.org/10.1016/j.ejmech.2022.114408openalex-snapshot
Design and synthesis of harmiquins, harmine and chloroquine hybrids as potent antiplasmodial agents
inferred← citeshttps://doi.org/10.1016/j.ejmech.2023.115458openalex-snapshot
Recent developments in antimalarial activities of 4-aminoquinoline derivatives
inferred← citeshttps://doi.org/10.1016/j.ejmech.2026.119027openalex-snapshot
A critical review of quinoline hybrids as privileged scaffolds for anti-malarial therapy
inferred← citeshttps://doi.org/10.1016/j.heliyon.2024.e25077openalex-snapshot
Biological evaluation of novel side chain containing CQTrICh-analogs as antimalarials and their development as PfCDPK1 kinase inhibitors
inferred← citeshttps://doi.org/10.1016/j.heliyon.2024.e26735openalex-snapshot
Synthesis, anticancer activity and molecular docking of new quinolines, quinazolines and 1,2,4-triazoles with pyrido[2,3-d] pyrimidines
inferred← citeshttps://doi.org/10.1016/j.jics.2024.101470openalex-snapshot
Synthesis of a novel 7-chloroquinoline-sulphocoumarin hybrid: Characterization, ADME profiling and elucidation of its antiproliferative and anti-EMT potential
inferred← citeshttps://doi.org/10.1016/j.jil.2025.100146openalex-snapshot
Ionic liquid-assisted approaches in the synthesis of nitrogen-containing heterocycles: A focus on 3- to 6-membered rings
inferred← citeshttps://doi.org/10.1016/j.molstruc.2024.138882openalex-snapshot
Quinoline-1,2,3-triazole hybrids: Design, synthesis, antimalarial and antimicrobial evaluation
inferred← citeshttps://doi.org/10.1016/j.molstruc.2024.140814openalex-snapshot
Integration of In-vivo screening, molecular docking, and molecular dynamics simulations for studying the antiepileptic potential of newly synthesized 5-naphthalen-1-yl-5,10-dihydro-1H-pyrimido[4,5-b]quinoline-2,4-diones in optimized reaction conditions by utilizing -proline as green catalyst
inferred← citeshttps://doi.org/10.1016/j.molstruc.2026.145705openalex-snapshot
Synthesis, anticancer and docking study of quinoline-linked pyrazine analogues
inferred← citeshttps://doi.org/10.1016/j.rechem.2024.101374openalex-snapshot
Novel styryl-heterocyclic hybrids: Synthesis, characterization and anticancer activity
inferred← citeshttps://doi.org/10.1021/acs.joc.1c00393openalex-snapshot
Rh(III)-Catalyzed Regioselective C8-Alkylation of Quinoline N-Oxides with Maleimides and Acrylates
inferred← citeshttps://doi.org/10.1021/acsmedchemlett.2c00531openalex-snapshot
Squaramide Tethered Clindamycin, Chloroquine, and Mortiamide Hybrids: Design, Synthesis, and Antimalarial Activity
inferred← citeshttps://doi.org/10.1039/d1gc02713aopenalex-snapshot
I 2 -induced cascade cyclization and dearomatization of indoles for the highly efficient synthesis of iodinated and vinylic spiroindolenines
inferred← citeshttps://doi.org/10.1039/d3md00083dopenalex-snapshot
Is structural hybridization invoking new dimensions for antimalarial drug discovery research?
inferred← citeshttps://doi.org/10.1039/d3sc06955aopenalex-snapshot
Rh( iii )-catalyzed sp 3 /sp 2 –C–H heteroarylations via cascade C–H activation and cyclization
inferred← citeshttps://doi.org/10.1039/d5cy00422eopenalex-snapshot
A passage from pincer complexes to rationally designed phosphine-free Co( iii ) catalysts supported by a pentadentate ligand for activation of alcohols: studies on sp 3 C–H alkylation of 9 H -fluorene and quinoline synthesis
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Metal–ligand cooperative strategy of a Zn-catalyst for multicomponent synthesis of highly substituted pyrazolines, pyrimidines, and quinolines: a combined experimental and DFT optimized study
inferred← citeshttps://doi.org/10.1039/d5cy01355kopenalex-snapshot
Mechanistic divergence in Rh( iii )-catalyzed cascades: how substrate identity switches between cyclization and migratory insertion
inferred← citeshttps://doi.org/10.1055/a-2122-8406openalex-snapshot
Photoredox Defluorinative Silylation of α-Trifluoromethyl Arylalkenes Using Silacarboxylic Acids as Silyl Radical Precursors
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Integrative computational and experimental approaches for identifying potent antimalarials by targeting falcipain-2 of Plasmodium falciparum
inferred← citeshttps://doi.org/10.1080/10406638.2021.1909082openalex-snapshot
Antitubercular, Antimalarial Activity and Molecular Docking Study of New Synthesized 7-Chloroquinoline Derivatives
inferred← citeshttps://doi.org/10.1080/13880209.2025.2547744openalex-snapshot
Design, evaluation, cytotoxic activity, molecular docking, ADMET analysis, and dynamic simulations and the preparation of new isoxazoles, thiazoles, 1,3-thiazines, and thiazolopyrimidines derived from quinoline-pyridopyrimidines
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Studying the Electrochemical Behavior of a Smooth Gold Electrode in a Solution of Bridged 1,2,4-Trioxalane in Acetonitrile
inferred← citeshttps://doi.org/10.1134/s0036024425703133openalex-snapshot
Electrochemical Behavior of Tricyclic Monoperoxide in an Acetonitrile Solution on Smooth Gold
inferred← citeshttps://doi.org/10.2174/0109298673308069240815072244openalex-snapshot
Therapeutic Targeting and Role of Cysteine Proteases in the Life Cycle of Malaria Parasite
inferred← citeshttps://doi.org/10.2174/1570180820666230830125155openalex-snapshot
Quinoline-hydrazone Conjugates: Recent Insights into Synthetic Strategies, Structure-activity Relationship, and Biological Activities
inferred← citeshttps://doi.org/10.2174/1570193x20666230505152611openalex-snapshot
Quinoline and Analogs: Insight into the Synthesis, Biological Activity, Structure-Activity Relationship, and Interaction with Targets
inferred← citeshttps://doi.org/10.29356/jmcs.v66i1.1578openalex-snapshot
2-Oxoquinoline Arylaminothiazole Derivatives in Identifying Novel Potential Anticancer Agents by Applying 3D-QSAR, Docking, and Molecular Dynamics Simulation Studies
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Synthesis and Antimalarial Activity of 7-Chloro-4-(4-(2-(Oxo, Hydroxyl & Fluoro-2-1 (4-Phenyl)Ethyl)Piperazin-1-yl)Quinoline Derivatives
inferred← citeshttps://doi.org/10.3389/fphar.2022.850176openalex-snapshot
Target-Based Virtual Screening of Natural Compounds Identifies a Potent Antimalarial With Selective Falcipain-2 Inhibitory Activity
inferred← citeshttps://doi.org/10.3390/antibiotics13020142openalex-snapshot
Synthesis of Novel Artemisinin, Ciprofloxacin, and Norfloxacin Hybrids with Potent Antiplasmodial Activity
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Synthesis of Ethyl Pyrimidine-Quinolincarboxylates Selected from Virtual Screening as Enhanced Lactate Dehydrogenase (LDH) Inhibitors
inferred← citeshttps://doi.org/10.3390/molecules27134123openalex-snapshot
Domino Nitro Reduction-Friedländer Heterocyclization for the Preparation of Quinolines
inferred← citeshttps://doi.org/10.3390/molecules27175401openalex-snapshot
Synthesis, Structure and Antileishmanial Evaluation of Endoperoxide–Pyrazole Hybrids
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Electrochemical behavior of bridged 1,2,4-dioxazolidine derivative in acetonitrile medium on the smooth gold
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