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The modulatory role of sulfated and non-sulfated small molecule heparan sulfate-glycomimetics in endothelial dysfunction: absolute structural clarification, molecular docking and simulated dynamics, SAR analyses and ADMET studies

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Automated docking using a Lamarckian genetic algorithm and an empirical binding free energy function

inferredcites →https://doi.org/10.1002/cbic.201900673openalex-snapshot

Chemical Methods for N‐ and O‐Sulfation of Small Molecules, Amino Acids and Peptides

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A Structure‐Reactivity Relationship of the Tandem Asymmetric Dihydroxylation on a Biologically Relevant Diene: Influence of Remote Stereocenters on Diastereofacial Selectivity

inferredcites →https://doi.org/10.1002/med.21625openalex-snapshot

Design and synthesis of glycomimetics: Recent advances

inferredcites →https://doi.org/10.1016/j.atherosclerosis.2011.08.033openalex-snapshot

HGF/c-Met signalling promotes Notch3 activation and human vascular smooth muscle cell osteogenic differentiation in vitro

inferredcites →https://doi.org/10.1016/j.bbagen.2016.08.013openalex-snapshot

A novel role for small molecule glycomimetics in the protection against lipid-induced endothelial dysfunction: Involvement of Akt/eNOS and Nrf2/ARE signaling

inferredcites →https://doi.org/10.1016/j.bmcl.2007.08.074openalex-snapshot

Novel heparin/heparan sulfate mimics as inhibitors of HGF/SF-induced MET activation

inferredcites →https://doi.org/10.1016/j.scr.2014.03.001openalex-snapshot

Glycosaminoglycan mimetic improves enrichment and cell functions of human endothelial progenitor cell colonies

inferredcites →https://doi.org/10.1016/s0969-2126(98)00138-5openalex-snapshot

Crystal structure of the NK1 fragment of human hepatocyte growth factor at 2.0 å resolution

inferredcites →https://doi.org/10.1021/acsmedchemlett.9b00590openalex-snapshot

Glycomimetic Based Approach toward Selective Carbonic Anhydrase Inhibitors

inferredcites →https://doi.org/10.1021/bi00179a006openalex-snapshot

Energetic Characterization of the Basic Fibroblast Growth Factor-Heparin Interaction: Identification of the Heparin Binding Domain

inferredcites →https://doi.org/10.1021/cr00032a009openalex-snapshot

Catalytic Asymmetric Dihydroxylation

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Prophylactic Antiviral Activity of Sulfated Glycomimetic Oligomers and Polymers

inferredcites →https://doi.org/10.1038/s41598-019-38921-zopenalex-snapshot

Diabetic endothelial colony forming cells have the potential for restoration with glycomimetics

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A novel exchange method to access sulfated molecules

inferredcites →https://doi.org/10.1039/c9cc01057bopenalex-snapshot

Sulfation made simple: a strategy for synthesising sulfated molecules

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A chalcone derivative, 1m‐6, exhibits atheroprotective effects by increasing cholesterol efflux and reducing inflammation‐induced endothelial dysfunction

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Lanthanum Chloride Inhibits LPS Mediated Expressions of Pro-Inflammatory Cytokines and Adhesion Molecules in HUVECs: Involvement of NF-κB-Jmjd3 Signaling

inferredcites →https://doi.org/10.1161/01.atv.0000051384.43104.fcopenalex-snapshot

Endothelial Dysfunction

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Iloprost improves endothelial barrier function in lipopolysaccharide-induced lung injury

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Role of free fatty acids in endothelial dysfunction

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NADPH Oxidases, Reactive Oxygen Species, and Hypertension

inferredcites →https://doi.org/10.2337/dc09-s330openalex-snapshot

Endothelial Dysfunction as a Target for Prevention of Cardiovascular Disease

inferredcites →https://doi.org/10.33594/000000141openalex-snapshot

Small Molecule Glycomimetics Inhibit Vascular Calcification via c-Met/Notch3/HES1 Signalling

inferredcites →https://doi.org/10.3390/ph12020055openalex-snapshot

Strategies for the Development of Glycomimetic Drug Candidates

inferredcites →https://doi.org/10.7150/ijbs.7502openalex-snapshot

The Vascular Endothelium and Human Diseases

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Chemical approaches to the sulfation of small molecules: current progress and future directions

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Approaches to the Sulfation of Small Molecules: Current Progress and Future Directions

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Are the mRNA vaccines inducing the Sanarelli-Shwartzman phenomenon?

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A Sulfuryl Group Transfer Strategy to Selectively Prepare Sulfated Steroids and Isotopically Labelled Derivatives

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Novel Glycomimetics Protect against Glycated Low-Density Lipoprotein-Induced Vascular Calcification In Vitro via Attenuation of the RAGE/ERK/CREB Pathway

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Sulfation of Phenolic Acids: Chemoenzymatic vs. Chemical Synthesis

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Rearrangement of Arylsulfamates and Sulfates to Para-Sulfonyl Anilines and Phenols

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Computational and Pharmacokinetic Investigation of Some Heterocyclic Amide Derivatives as Cyclooxygenase Inhibitors: An In-Silico Approach

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