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Determination of metallic nanoparticles in biological samples by single particle ICP-MS: a systematic review from sample collection to analysis

https://doi.org/10.1039/d1en00680k
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Strategies for robust and accurate experimental approaches to quantify nanomaterial bioaccumulation across a broad range of organisms
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ICP-MS for the analysis at the nanoscale – a tutorial review
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Elucidation of the fate of zinc in model plants using single particle ICP-MS and ESI tandem MS
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Translocation of silver nanoparticles in the ex vivo human placenta perfusion model characterized by single particle ICP-MS
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Opportunities for examining the natural nanogeochemical environment using recent advances in nanoparticle analysis
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A critical review of single particle inductively coupled plasma mass spectrometry – A step towards an ideal method for nanomaterial characterization
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Silver nanoparticles inhaled during pregnancy reach and affect the placenta and the foetus
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Impact of in vitro digestion on gastrointestinal fate and uptake of silver nanoparticles with different surface modifications
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Silicon dioxide and titanium dioxide particles found in human tissues
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Proteinase K from Tritirachium album Limber
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Guidance on risk assessment of nanomaterials to be applied in the food and feed chain: human and animal health
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Behaviour of silver nanoparticles and silver ions in an in vitro human gastrointestinal digestion model
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Oral, short-term exposure to titanium dioxide nanoparticles in Sprague-Dawley rat: focus on reproductive and endocrine systems and spleen
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Reference materials and representative test materials to develop nanoparticle characterization methods: the NanoChOp project case
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Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Icp-Ms Based Platforms for Tracing Studies of Isotopically Labeled Selenium Nanoparticles in Plants
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Advances in ICP‐MS‐Based Nanoparticle Characterization: Techniques and Challenges in Biological Sample Analysis
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Titanium Detected in Liver, Kidney, Spleen, and Intestine Is Not Related to Dose, Time, or Route of Exposure to Titanium Dioxide: A Systematic Review
inferred← citeshttps://doi.org/10.1002/tqem.70136openalex-snapshot
Toxicological Concerns of Nanomaterials in Agroecosystem: Risk, Fate, and Their Analytical and Regulatory Assessment
inferred← citeshttps://doi.org/10.1007/978-981-99-2874-3_6openalex-snapshot
Recent Advances in Nanoparticles for Environmental Monitoring and Sensing: An Overview
inferred← citeshttps://doi.org/10.1007/s00216-022-04260-8openalex-snapshot
Facets of ICP-MS and their potential in the medical sciences—Part 2: nanomedicine, immunochemistry, mass cytometry, and bioassays
inferred← citeshttps://doi.org/10.1007/s00216-023-04641-7openalex-snapshot
Basic and advanced spectrometric methods for complete nanoparticles characterization in bio/eco systems: current status and future prospects
inferred← citeshttps://doi.org/10.1007/s00216-025-06144-zopenalex-snapshot
Deciphering the formation of biogenic nanoparticles and their protein corona: State-of-the-art and analytical challenges
inferred← citeshttps://doi.org/10.1007/s00216-026-06797-4openalex-snapshot
Evaluation of extraction capabilities of protease, proteinase K, and TMAH for nanoparticle characterization in biological CRMs by spICP-MS
inferred← citeshttps://doi.org/10.1007/s00604-023-05777-0openalex-snapshot
Comparative study of extraction methods of silver species from faeces of animals fed with silver-based nanomaterials
inferred← citeshttps://doi.org/10.1007/s44169-023-00046-wopenalex-snapshot
Environmental Carriers for Metal Nanoparticles: Transport, Fate, and Eco-risks
inferred← citeshttps://doi.org/10.1016/b978-0-323-91233-4.00006-5openalex-snapshot
Nanotechnology for aquaculture and fisheries
inferred← citeshttps://doi.org/10.1016/j.chemosphere.2024.143460openalex-snapshot
Evaluation of extraction and storage conditions for quantification and characterization of silver nanoparticles in complex samples by single particle-ICP-MS
inferred← citeshttps://doi.org/10.1016/j.envpol.2024.123617openalex-snapshot
Oxidative stress and potential effects of metal nanoparticles: A review of biocompatibility and toxicity concerns
inferred← citeshttps://doi.org/10.1016/j.envres.2022.114736openalex-snapshot
Human biomonitoring and personal air monitoring. An integrated approach to assess exposure of stainless-steel welders to metal-oxide nanoparticles
inferred← citeshttps://doi.org/10.1016/j.envres.2024.119665openalex-snapshot
Current insights into the green synthesis, in planta characterization and phytoeffects of nickel nanoparticles and their agricultural implications
inferred← citeshttps://doi.org/10.1016/j.impact.2023.100487openalex-snapshot
European nanomaterial legislation in the past 20 years – Closing the final gaps
inferred← citeshttps://doi.org/10.1016/j.impact.2026.100639openalex-snapshot
Soil organic matter fractions govern the transformation of selenium nanoparticles: a multi-technique analytical study
inferred← citeshttps://doi.org/10.1016/j.jclepro.2024.143454openalex-snapshot
Recent advances in the detection and quantification of manufactured nanoparticles (MNPs) in complex environmental and biological matrices
inferred← citeshttps://doi.org/10.1016/j.jhazmat.2025.139734openalex-snapshot
Optimized extraction, quantification and characterization of seven environmentally relevant metallic nanoparticles in sewage sludge: Occurrence, composition and environmental risk assessment
inferred← citeshttps://doi.org/10.1016/j.jtemin.2023.100054openalex-snapshot
Sizing silver nanoparticles in biological matrices by spICP-MS
inferred← citeshttps://doi.org/10.1016/j.micres.2026.128683openalex-snapshot
Nanoparticles in climate-resilient agriculture: Biological mechanisms, rhizosphere interactions, and yield enhancement under abiotic stress
inferred← citeshttps://doi.org/10.1016/j.microc.2023.108864openalex-snapshot
Characterization of colloidal particles of a biological and metallic nature
inferred← citeshttps://doi.org/10.1016/j.microc.2025.113283openalex-snapshot
SP-ICP-MS mass shift mode as an optimal strategy for characterizing titanium dioxide nanoparticles in urine and blood samples
inferred← citeshttps://doi.org/10.1016/j.microc.2026.117861openalex-snapshot
Single particle ICP-MS detection of metal oxide nanoparticles in human samples, providing a powerful tool to assess the population exposure and risk assessment
inferred← citeshttps://doi.org/10.1016/j.microc.2026.119834openalex-snapshot
Single-particle ICP-MS monitoring of aptamer-mediated nanoparticle aggregation for highly sensitive pancreatic polypeptide detection
inferred← citeshttps://doi.org/10.1016/j.mtchem.2026.103694openalex-snapshot
Targeting effects in manganese based MRI nanoarchitectures under corona and clearance constraints
inferred← citeshttps://doi.org/10.1016/j.nantod.2023.102065openalex-snapshot
An integrated approach to testing and assessment (IATA) to support grouping and read-across of nanomaterials in aquatic systems
inferred← citeshttps://doi.org/10.1016/j.pedsph.2023.05.004openalex-snapshot
Effects and fate of metal-based engineered nanomaterials in soil ecosystem: A review
inferred← citeshttps://doi.org/10.1016/j.resconrec.2026.109174openalex-snapshot
Plant-derived green nanomaterials: From biosynthesis to biocompatible applications in sustainable agriculture
inferred← citeshttps://doi.org/10.1016/j.talanta.2026.129574openalex-snapshot
Assessment of sample preparation for single particle ICP-MS determination of mercury selenide nanoparticles in fish tissues within mercury speciation framework
inferred← citeshttps://doi.org/10.1016/j.talanta.2026.129575openalex-snapshot
Towards the harmonization of raw data processing in single particle inductively coupled plasma mass spectrometry
inferred← citeshttps://doi.org/10.1016/j.tifs.2023.104127openalex-snapshot
Microalgae with active biological metal-nanoparticles as a novel food. Biosynthesis, characterization and bioavailability investigation – Review
inferred← citeshttps://doi.org/10.1016/j.toxac.2026.06.001openalex-snapshot
Association between blood lead and cadmium and autoimmune thyroiditis in Egyptian women. A case-control study
inferred← citeshttps://doi.org/10.1016/j.trac.2024.117673openalex-snapshot
The emerging field of inductively coupled plasma mass spectrometry for (micro)nanoplastic analysis: “The 3As” analysis, advances, and applications
inferred← citeshttps://doi.org/10.1016/j.trac.2024.118031openalex-snapshot
Analytical methods for identification, characterization, and quantification of metal-containing nanoparticles in biological and biomedical samples, food and personal care products
inferred← citeshttps://doi.org/10.1016/j.trac.2026.118674openalex-snapshot
Emergent analytical strategies and tools to track functional inorganic nanomaterials applied for sustainable agriculture
inferred← citeshttps://doi.org/10.1016/j.trac.2026.118878openalex-snapshot
Advances in metallomics for pancreatic cancer: Analytical strategies for biomarker discovery
inferred← citeshttps://doi.org/10.1021/acs.analchem.5c06975openalex-snapshot
A Simple Online Internal Standard Calibration Strategy for Single-Particle Inductively Coupled Plasma Mass Spectrometry Based on Multielement Analysis
inferred← citeshttps://doi.org/10.1021/acs.est.5c18660openalex-snapshot
Probing the Environmental Persistence of Inorganic Nanoparticles and Micro(nano)plastics by Single-Particle ICP-MS
inferred← citeshttps://doi.org/10.1021/acs.est.6c02876openalex-snapshot
Attribute-Driven Maternal–Fetal Transfer of Atmospheric Magnetite Nanoparticles Revealed by Single-Particle Analysis
inferred← citeshttps://doi.org/10.1021/acs.jafc.5c08829openalex-snapshot
Recent Advances in Safety Assessment of Nanocellulose in Food Packaging
inferred← citeshttps://doi.org/10.1021/acsomega.5c05971openalex-snapshot
Determination of Essential and Toxic Elements by ICP–MS in Herbal Medicines
inferred← citeshttps://doi.org/10.1039/d3en00459gopenalex-snapshot
Ecotoxicity testing of nanomaterials in sediment – suggestions to improve science and regulation
inferred← citeshttps://doi.org/10.1039/d4en00416gopenalex-snapshot
Evaluation of alternative bases to TMAH for tissue extraction of ENMs from tissues prior to spICP-MS analysis
inferred← citeshttps://doi.org/10.1039/d5ja00179jopenalex-snapshot
Self-organizing maps for the detection and classification of natural nanoparticles, nanoparticle systems and engineered nanoparticles characterized using single particle ICP-time-of-flight-MS
inferred← citeshttps://doi.org/10.1039/d5ja00285kopenalex-snapshot
Improved single particle ICP-MS assessment using a novel Python-based data processing algorithm (Sparta) for nanoparticle quantification
inferred← citeshttps://doi.org/10.1039/d6ja00187dopenalex-snapshot
Single particle inductively coupled plasma mass spectrometry: where it comes from and where it is heading
inferred← citeshttps://doi.org/10.1051/bioconf/202625002002openalex-snapshot
Recent Applications on Measurements of Toxic Elements by ICP-MS in Food Samples
inferred← citeshttps://doi.org/10.1080/00387010.2026.2734305openalex-snapshot
Analysis of particle size effect of stainless steel powder by laser-induced breakdown spectroscopy based on multivariate quantitative model
inferred← citeshttps://doi.org/10.1080/01904167.2026.2688253openalex-snapshot
Foliar zinc oxide nanoparticles for cereal biofortification: dose–response and quality
inferred← citeshttps://doi.org/10.1080/15376516.2026.2739342openalex-snapshot
Microplastics and nanoplastics in humans: a critical ADME appraisal and the case for quantitative risk assessment
inferred← citeshttps://doi.org/10.1080/17435390.2023.2301692openalex-snapshot
Biomarkers of exposure and effect in human biomonitoring of metal-based nanomaterials: their use in primary prevention and health surveillance
inferred← citeshttps://doi.org/10.1080/17435390.2025.2454969openalex-snapshot
Knock-out mouse models and single particle ICP-MS reveal that SP-D and SP-A deficiency reduces agglomeration of inhaled gold nanoparticles in vivo without significant changes to overall lung clearance
inferred← citeshttps://doi.org/10.1080/17435889.2026.2683542openalex-snapshot
Single-entity analysis of therapeutic nanoparticles: from orthogonal metrology to AI
inferred← citeshttps://doi.org/10.1093/jaoacint/qsae024openalex-snapshot
Validation of a Method for Surveillance of Nanoparticles in Mussels Using Single-Particle Inductively Coupled Plasma-Mass Spectrometry
inferred← citeshttps://doi.org/10.1093/mtomcs/mfac088openalex-snapshot
The potential of bioprinting for preparation of nanoparticle-based calibration standards for LA-ICP-ToF-MS quantitative imaging
inferred← citeshttps://doi.org/10.1134/s106193482310012xopenalex-snapshot
Methods of Atomic Spectroscopy in Studying Properties and the Behavior of Nanoscale Magnetic Materials in Biological Systems
inferred← citeshttps://doi.org/10.1134/s1061934825700042openalex-snapshot
Main Strategies of the Sample Preparation of Biological Samples Containing Nanoparticles for Their Subsequent Analysis by Single Particle Inductively Coupled Plasma Mass Spectrometry: A Mini-Review
inferred← citeshttps://doi.org/10.1177/02611929241304972openalex-snapshot
The Use of an In Chemico Digestibility Assay to Reduce the In Vivo Fish Bioaccumulation Testing of Nanomaterials
inferred← citeshttps://doi.org/10.1364/oe.567763openalex-snapshot
Observation of gold nanoparticle Brownian motion via localized surface plasmon resonance enhanced highly inclined illumination microscopy
inferred← citeshttps://doi.org/10.2147/ijn.s567996openalex-snapshot
Quantifying Nanoplastic Toxicity Using Gold-Core Polystyrene Nanoparticles: In vivo Evaluation and Human Risk Extrapolation
inferred← citeshttps://doi.org/10.2147/nsa.s558176openalex-snapshot
Revolutionizing Food Safety: A Systematic Review of Nanotechnology-Based Aflatoxin Detection (2010–2023)
inferred← citeshttps://doi.org/10.2903/sp.efsa.2024.en-8826openalex-snapshot
Review of New Approach Methodologies for Application in Risk Assessment of Nanoparticles in the Food and Feed Sector: Status and Challenges
inferred← citeshttps://doi.org/10.31857/s0044450223100122openalex-snapshot
Methods of Atomic Spectroscopy in Studying Properties and the Behavior of Nanoscale Magnetic Materials in Biological Systems
inferred← citeshttps://doi.org/10.3389/ftox.2025.1629813openalex-snapshot
25 years of research and regulation: Is nanotechnology safe to commercialize?
inferred← citeshttps://doi.org/10.3390/analytica7010009openalex-snapshot
Single-Particle ICP-MS Method for the Determination of TiO2 Nano- and Submicrometric Particles in Biological Tissues
inferred← citeshttps://doi.org/10.3390/jox15050154openalex-snapshot
Separation and Detection of Microplastics in Human Exposure Pathways: Challenges, Analytical Techniques, and Emerging Solutions
inferred← citeshttps://doi.org/10.3390/molecules28114442openalex-snapshot
Analysis of Silver Nanoparticles in Ground Beef by Single Particle Inductively Coupled Plasma Mass Spectrometry (SP-ICP-MS)
inferred← citeshttps://doi.org/10.3390/molecules30071647openalex-snapshot
Developing a Multi-Method Approach for Understanding Cellular Uptake and Biological Response: Investigating Co-Exposure of Macrophage-like Differentiated THP-1 Cells to Al2O3 and CeO2 Nanoparticles
inferred← citeshttps://doi.org/10.3390/nano13182547openalex-snapshot
Application of Single Particle ICP-MS for the Determination of Inorganic Nanoparticles in Food Additives and Food: A Short Review
inferred← citeshttps://doi.org/10.3390/nano14070637openalex-snapshot
An Unprecedented Metal Distribution in Silica Nanoparticles Determined by Single-Particle Inductively Coupled Plasma Mass Spectrometry
inferred← citeshttps://doi.org/10.46770/as.2022.108openalex-snapshot
ICP-MS-Based Methodology In Metallomics: Towards Single Particle Analysis, Single Cell Analysis, And Spatial Metallomics
Editorial review for independent work. ICSAC — the Institute for Complexity Science and Advanced Computing — runs a structured editorial panel for researchers publishing outside journals, and publishes on CiteStamp rails. Submission is free and goes through ORCID: icsacinstitute.org/submit.