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The role of adjuvants in overcoming antibacterial resistance due to enzymatic drug modification
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Overview on mechanisms of isoniazid action and resistance in Mycobacterium tuberculosis
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Inhibitors of metallo-β-lactamases
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Diversity in fosfomycin resistance proteins
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Limited distribution and mechanism of the TetX4 tetracycline resistance enzyme
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Allosteric Inhibition of Aminoglycoside Phosphotransferase by a Designed Ankyrin Repeat Protein
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Structural Basis for Kinase-Mediated Macrolide Antibiotic Resistance
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Substrate specificity and structure-activity relationships of gentamicin acetyltransferase I. The dependence of antibiotic resistance upon substrate Vmax/Km values.
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Inactivation of lincosaminide antibiotics in Staphylococcus. Identification of lincosaminide O-nucleotidyltransferases and comparison of the corresponding resistance genes.
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Unique features in the ribosome binding site sequence of the gram-positive Staphylococcus aureus beta-lactamase gene.
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The Structural Basis for the Action of the Antibiotics Tetracycline, Pactamycin, and Hygromycin B on the 30S Ribosomal Subunit
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Structural Mechanism for Rifampicin Inhibition of Bacterial RNA Polymerase
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Purification and characterization of an erythromycin esterase from an erythromycin-resistant Pseudomonas sp.
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Characteristic expression of three genes,msr(A),mph(C) anderm(Y), that confer resistance to macrolide antibiotics onStaphylococcus aureus
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GCN5-related histone N-acetyltransferases belong to a diverse superfamily that includes the yeast SPT10 protein
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Attributable deaths caused by infections with antibiotic-resistant bacteria in France
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The Enzymes of the Rifamycin Antibiotic Resistome
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Discovery of Taniborbactam (VNRX-5133): A Broad-Spectrum Serine- and Metallo-β-lactamase Inhibitor for Carbapenem-Resistant Bacterial Infections
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Modulation of a Mycobacterial ADP-Ribosyltransferase to Augment Rifamycin Antibiotic Resistance
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Semisynthetic Analogues of Anhydrotetracycline as Inhibitors of Tetracycline Destructase Enzymes
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Synergistic Effect of Chlorogenic Acid and Caffeic Acid with Fosfomycin on Growth Inhibition of a Resistant Listeria monocytogenes Strain
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3-(Bromoacetyl)chloramphenicol, an active site-directed inhibitor for chloramphenicol acetyltransferase
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Phosphonoformate: A Minimal Transition State Analogue Inhibitor of the Fosfomycin Resistance Protein, FosA ,
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The Fungal Product Terreic Acid Is a Covalent Inhibitor of the Bacterial Cell Wall Biosynthetic Enzyme UDP-N-Acetylglucosamine 1-Carboxyvinyltransferase (MurA),
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Mechanism and Diversity of the Erythromycin Esterase Family of Enzymes
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Structure and Function of the Genomically Encoded Fosfomycin Resistance Enzyme, FosB, from Staphylococcus aureus
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Structure and Mechanism of the Genomically Encoded Fosfomycin Resistance Protein, FosX, from Listeria monocytogenes,
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Mechanistic and Structural Analysis of Aminoglycoside N-Acetyltransferase AAC(6′)-Ib and Its Bifunctional, Fluoroquinolone-Active AAC(6′)-Ib-cr Variant
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Aminoglycoside Antibiotics in the 21st Century
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Bacterial Resistance to β-Lactam Antibiotics: Compelling Opportunism, Compelling Opportunity
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RifamycinMode of Action, Resistance, and Biosynthesis
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Chemical Studies on Lincomycin. I. The Structure of Lincomycin
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Evolving Carbapenemases: Can Medicinal Chemists Advance One Step Ahead of the Coming Storm?
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Synthesis of Bacillithiol and the Catalytic Selectivity of FosB-Type Fosfomycin Resistance Proteins
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Nucleotide sequence analysis of the chloramphenicol resistance transposon Tn9
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Structural basis for the interaction of antibiotics with the peptidyl transferase centre in eubacteria
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Monooxygenation of rifampicin catalyzed by the rox gene product of Nocardia farcinica: structure elucidation, gene identification and role in drug resistance
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The genome sequence of Bacillus anthracis Ames and comparison to closely related bacteria
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Plasticity, dynamics, and inhibition of emerging tetracycline resistance enzymes
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Rifampin phosphotransferase is an unusual antibiotic resistance kinase
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A diverse intrinsic antibiotic resistome from a cave bacterium
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Rifamycin antibiotics and the mechanisms of their failure
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Pharmacological evaluation of disulfiram analogs as antimicrobial agents and their application as inhibitors of fosB-mediated fosfomycin resistance
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The evolution of substrate discrimination in macrolide antibiotic resistance enzymes
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Structural and functional insights into esterase-mediated macrolide resistance
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Plasmid-encoded tet(X) genes that confer high-level tigecycline resistance in Escherichia coli
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Understanding and overcoming aminoglycoside resistance caused by N-6′-acetyltransferase
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Comparison of chloramphenicol acetyltransferase variants in staphylococci. Purification, inhibitor studies and N-terminal sequences
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A standard numbering scheme for the class A β -lactamases
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Two glycosyltransferases and a glycosidase are involved in oleandomycin modification during its biosynthesis by Streptomyces antibioticus
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Arylamine N‐acetyltransferase of Mycobacterium tuberculosis is a polymorphic enzyme and a site of isoniazid metabolism
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Structure–activity relationships of ketolides vs. macrolides
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Rifamycin antibiotic resistance by ADP-ribosylation: Structure and diversity of Arr
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Unusual regioversatility of acetyltransferase Eis, a cause of drug resistance in XDR-TB
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Structural basis of rifampin inactivation by rifampin phosphotransferase
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Kinetics of drug–ribosome interactions defines the cidality of macrolide antibiotics
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Structure of chloramphenicol acetyltransferase at 1.75-A resolution.
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Inactivation of Chloramphenicol by O-Phosphorylation
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Inhibition of Aminoglycoside Antibiotic Resistance Enzymes by Protein Kinase Inhibitors
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Kinetics of Avibactam Inhibition against Class A, C, and D β-Lactamases
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The Structure of the Antibiotic Deactivating, N-hydroxylating Rifampicin Monooxygenase
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TetX Is a Flavin-dependent Monooxygenase Conferring Resistance to Tetracycline Antibiotics
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The role of integrons in antibiotic resistance gene capture
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Beta-lactamase database (BLDB) – structure and function
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Fosfomycin: Use Beyond Urinary Tract and Gastrointestinal Infections
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Dissemination of Aminoglycoside-Modifying Enzymes and 16S rRNA Methylases Among Acinetobacter baumannii and Pseudomonas aeruginosa Isolates
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Ceftazidime/Avibactam and Ceftolozane/Tazobactam: Second-generation β-Lactam/β-Lactamase Inhibitor Combinations
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Structural basis for selectivity and toxicity of ribosomal antibiotics
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Crystal structures of complexes of the small ribosomal subunit with tetracycline, edeine and IF3
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Optimizing aminoglycoside selection for KPC-producing Klebsiella pneumoniae with the aminoglycoside-modifying enzyme (AME) gene aac(6’)-Ib
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An integron cassette encoding erythromycin esterase, ere(A), from Providencia stuartii
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OP0595, a new diazabicyclooctane: mode of action as a serine β-lactamase inhibitor, antibiotic and β-lactam ‘enhancer’
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Glutathione-S-transferase FosA6 ofKlebsiella pneumoniaeorigin conferring fosfomycin resistance in ESBL-producingEscherichia coli
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Clinical effectiveness of carbapenems versus alternative antibiotics for treating ESBL-producing Enterobacteriaceae bacteraemia: a systematic review and meta-analysis
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Mol* Viewer: modern web app for 3D visualization and analysis of large biomolecular structures
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CARD 2020: antibiotic resistome surveillance with the comprehensive antibiotic resistance database
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Some Properties of Chloramphenicol Acetyltransferase, with Particular Reference to the Mechanism of Inhibition by Basic Triphenylmethane Dyes
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Genetic identity of aminoglycoside-resistance genes in Escherichia coli isolates from human and animal sources
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Expression, production and release of the Eis protein by Mycobacterium tuberculosis during infection of macrophages and its effect on cytokine secretion
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β-Lactams and β-Lactamase Inhibitors: An Overview
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Putative dioxygen-binding sites and recognition of tigecycline and minocycline in the tetracycline-degrading monooxygenase TetX
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Structure of fosfomycin resistance protein FosA from transposon Tn2921
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Binding of the anti‐tubercular drug isoniazid to the arylamine N‐acetyltransferase protein from Mycobacterium smegmatis
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Crystal structure of the aminoglycosides N‐acetyltransferase Eis2 from Mycobacterium abscessus
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Mechanisms of action of isoniazid
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Structure-activity relationships of ketolides vs. macrolides
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Sulbactam-containing β-lactamase inhibitor combinations
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Identification of a novel fosfomycin resistance gene (fosA2) in Enterobacter cloacae from the Salmon River, Canada
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Gentamicin resistance genes in environmental bacteria: prevalence and transfer
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A plasmid that encodes three genes for resistance to macrolide antibiotics inStaphylococcus aureus
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Resistance phenotypes conferred by macrolide phosphotransferases
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THE MECHANISM OF ACTION OF FOSFOMYCIN (PHOSPHONOMYCIN)
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Characterization of fosA5 , a new plasmid-mediated fosfomycin resistance gene in Escherichia coli
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New β‐lactam–β‐lactamase inhibitor combinations in clinical development
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Chloromycetin, a New Antibiotic From a Soil Actinomycete
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Structural Aspects of Aminoglycoside-Modifying Enzymes
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Detection of New arr-4 and arr-5 Gene Cassettes in Clinical Pseudomonas aeruginosa and Klebsiella pneumoniae Strains from Brazil
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bla CMY-2 -Positive IncA/C Plasmids from Escherichia coli and Salmonella enterica Are a Distinct Component of a Larger Lineage of Plasmids
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Pharmacokinetics-Pharmacodynamics of Enmetazobactam Combined with Cefepime in a Neutropenic Murine Thigh Infection Model
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Chloramphenicol Is a Substrate for a Novel Nitroreductase Pathway in Haemophilus influenzae
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Macrolide and Azithromycin Use Are Linked to Increased Macrolide Resistance in Streptococcus pneumoniae
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First Detection of a Fosfomycin Resistance Gene, fosA7 , in Salmonella enterica Serovar Heidelberg Isolated from Broiler Chickens
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Acetylation of Isoniazid Is a Novel Mechanism of Isoniazid Resistance in Mycobacterium tuberculosis
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Past and Present Perspectives on β-Lactamases
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In Vitro Activity of WCK 5222 (Cefepime-Zidebactam) against Worldwide Collected Gram-Negative Bacilli Not Susceptible to Carbapenems
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VNRX-5133 (Taniborbactam), a Broad-Spectrum Inhibitor of Serine- and Metallo-β-Lactamases, Restores Activity of Cefepime in Enterobacterales and Pseudomonas aeruginosa
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Interactions of OP0595, a Novel Triple-Action Diazabicyclooctane, with β-Lactams against OP0595-Resistant Enterobacteriaceae Mutants
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Extended-Spectrum β-Lactamases: a Clinical Update
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Isolation and nucleotide sequencing of an aminocyclitol acetyltransferase gene from Streptomyces rimosus forma paromomycinus
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Evidence that a novel tetracycline resistance gene found on two Bacteroides transposons encodes an NADP-requiring oxidoreductase
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The chloramphenicol acetyltransferase gene of Tn2424: a new breed of cat
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Cloning and Characterization of Arylamine N -Acetyltransferase Genes from Mycobacterium smegmatis and Mycobacterium tuberculosis : Increased Expression Results in Isoniazid Resistance
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Incoming claims: where this work appears in other papers’ reference lists and arguments.
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Countering Aminoglycoside Modifying Enzymes
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