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Innate Immunity and Asthma Risk in Amish and Hutterite Farm Children

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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A gene signature of inhibitory MHC receptors identifies a BDCA3 + subset of IL‐10‐induced dendritic cells with reduced allostimulatory capacity in vitro
inferredcites →https://doi.org/10.1016/j.jaci.2007.01.037openalex-snapshot
Not all farming environments protect against the development of asthma and wheeze in children
inferredcites →https://doi.org/10.1016/j.jaci.2009.01.056openalex-snapshot
Maternal farm exposure modulates neonatal immune mechanisms through regulatory T cells
inferredcites →https://doi.org/10.1016/j.jaci.2010.09.041openalex-snapshot
Gene-environment interaction for childhood asthma and exposure to farming in Central Europe
inferredcites →https://doi.org/10.1016/j.jaci.2011.06.046openalex-snapshot
Rising prevalence of asthma is sex-specific in a US farming population
inferredcites →https://doi.org/10.1016/j.jaci.2011.10.038openalex-snapshot
Interferon regulatory factor 7 is a major hub connecting interferon-mediated responses in virus-induced asthma exacerbations in vivo
inferredcites →https://doi.org/10.1016/j.jaci.2012.03.016openalex-snapshot
Amish children living in northern Indiana have a very low prevalence of allergic sensitization
inferredcites →https://doi.org/10.1016/j.jaci.2013.06.034openalex-snapshot
Increased regulatory T-cell numbers are associated with farm milk exposure and lower atopic sensitization and asthma in childhood
inferredcites →https://doi.org/10.1016/s1074-7613(00)80596-8openalex-snapshot
Targeted Disruption of the MyD88 Gene Results in Loss of IL-1- and IL-18-Mediated Function
inferredcites →https://doi.org/10.1016/s2213-2600(14)70012-8openalex-snapshot
Asthma genetics and personalised medicine
inferredcites →https://doi.org/10.1038/cmi.2011.8openalex-snapshot
The increase in surface CXCR4 expression on lung extravascular neutrophils and its effects on neutrophils during endotoxin-induced lung injury
inferredcites →https://doi.org/10.1038/ni.2284openalex-snapshot
Genetic variation in Toll-like receptors and disease susceptibility
inferredcites →https://doi.org/10.1038/nri3313openalex-snapshot
A20: linking a complex regulator of ubiquitylation to immunity and human disease
inferredcites →https://doi.org/10.1056/nejmoa020057openalex-snapshot
Environmental Exposure to Endotoxin and Its Relation to Asthma in School-Age Children
inferredcites →https://doi.org/10.1056/nejmoa1007302openalex-snapshot
Exposure to Environmental Microorganisms and Childhood Asthma
inferredcites →https://doi.org/10.1056/nejmoa1211592openalex-snapshot
Rhinovirus Wheezing Illness and Genetic Risk of Childhood-Onset Asthma
inferredcites →https://doi.org/10.1056/nejmra020100openalex-snapshot
The Effect of Infections on Susceptibility to Autoimmune and Allergic Diseases
inferredcites →https://doi.org/10.1073/pnas.1110946108openalex-snapshot
Tripartite motif 8 (TRIM8) modulates TNFα- and IL-1β–triggered NF-κB activation by targeting TAK1 for K63-linked polyubiquitination
inferredcites →https://doi.org/10.1084/jem.20130056openalex-snapshot
Neutrophil mobilization via plerixafor-mediated CXCR4 inhibition arises from lung demargination and blockade of neutrophil homing to the bone marrow
inferredcites →https://doi.org/10.1093/jac/dkt468openalex-snapshot
Efavirenz induces interactions between leucocytes and endothelium through the activation of Mac-1 and gp150,95
inferredcites →https://doi.org/10.1097/ccm.0000000000000100openalex-snapshot
Immunological Characterization of Compensatory Anti-Inflammatory Response Syndrome in Patients With Severe Sepsis
inferredcites →https://doi.org/10.1111/j.1365-2249.2008.03791.xopenalex-snapshot
Human neutrophils switch to an activated phenotype after homing to the lung irrespective of inflammatory disease
inferredcites →https://doi.org/10.1111/j.1600-065x.2011.01029.xopenalex-snapshot
The genetics of asthma and allergic disease: a 21st century perspective
inferredcites →https://doi.org/10.1111/j.2517-6161.1995.tb02031.xopenalex-snapshot
Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing
inferredcites →https://doi.org/10.1126/science.1087262openalex-snapshot
Role of Adaptor TRIF in the MyD88-Independent Toll-Like Receptor Signaling Pathway
inferredcites →https://doi.org/10.1126/science.296.5566.261bopenalex-snapshot
A Human Genome Diversity Cell Line Panel
inferredcites →https://doi.org/10.1126/science.aac6623openalex-snapshot
Farm dust and endotoxin protect against allergy through A20 induction in lung epithelial cells
inferredcites →https://doi.org/10.1164/rccm.200903-0363ocopenalex-snapshot
Granulocyte–Macrophage Colony-stimulating Factor to Reverse Sepsis-associated Immunosuppression: A Double-Blind, Randomized, Placebo-controlled Multicenter Trial
inferredcites →https://doi.org/10.1164/rccm.201507-1493ocopenalex-snapshot
The Early Development of Wheeze. Environmental Determinants and Genetic Susceptibility at 17q21
inferredcites →https://doi.org/10.4049/jimmunol.176.5.2790openalex-snapshot
Recombinant Ig-Like Transcript 3-Fc Modulates T Cell Responses via Induction of Th Anergy and Differentiation of CD8+ T Suppressor Cells
inferredcites →https://doi.org/10.56021/9780801844416openalex-snapshot
Amish Society

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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inferred← citeshttps://doi.org/10.1007/7854_2022_385openalex-snapshot
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inferred← citeshttps://doi.org/10.1007/978-3-030-03395-8_13openalex-snapshot
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inferred← citeshttps://doi.org/10.1007/978-3-030-11751-1_5openalex-snapshot
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inferred← citeshttps://doi.org/10.1007/978-3-030-87104-8_5openalex-snapshot
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inferred← citeshttps://doi.org/10.1007/978-3-030-91051-8_1openalex-snapshot
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inferred← citeshttps://doi.org/10.1007/978-3-030-91051-8_3openalex-snapshot
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inferred← citeshttps://doi.org/10.1007/978-3-030-91051-8_8openalex-snapshot
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inferred← citeshttps://doi.org/10.1007/978-3-031-32259-4_3openalex-snapshot
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inferred← citeshttps://doi.org/10.1007/978-3-031-80029-0_1openalex-snapshot
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inferred← citeshttps://doi.org/10.1007/978-3-031-82689-4_5openalex-snapshot
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inferred← citeshttps://doi.org/10.1007/978-3-319-69968-4_4openalex-snapshot
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inferred← citeshttps://doi.org/10.1007/978-3-319-69968-4_8openalex-snapshot
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inferred← citeshttps://doi.org/10.1007/978-3-319-77485-5_1openalex-snapshot
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inferred← citeshttps://doi.org/10.1007/978-3-662-58140-7_4openalex-snapshot
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inferred← citeshttps://doi.org/10.1007/978-3-662-58140-7_5openalex-snapshot
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inferred← citeshttps://doi.org/10.1007/978-3-662-61586-7_4openalex-snapshot
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inferred← citeshttps://doi.org/10.1007/s10393-020-01493-wopenalex-snapshot
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inferred← citeshttps://doi.org/10.1007/s10620-020-06123-7openalex-snapshot
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inferred← citeshttps://doi.org/10.1007/s11882-020-00936-2openalex-snapshot
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inferred← citeshttps://doi.org/10.1007/s11882-022-01034-1openalex-snapshot
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inferred← citeshttps://doi.org/10.1007/s11882-022-01061-yopenalex-snapshot
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inferred← citeshttps://doi.org/10.1007/s11882-023-01081-2openalex-snapshot
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inferred← citeshttps://doi.org/10.1007/s11882-025-01240-7openalex-snapshot
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inferred← citeshttps://doi.org/10.1007/s11882-026-01284-3openalex-snapshot
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inferred← citeshttps://doi.org/10.1007/s15006-017-9432-9openalex-snapshot
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inferred← citeshttps://doi.org/10.1007/s15007-021-4798-5openalex-snapshot
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inferred← citeshttps://doi.org/10.1007/s15012-017-2381-2openalex-snapshot
Allergologischer Rundumschlag
inferred← citeshttps://doi.org/10.1007/s15033-017-0609-9openalex-snapshot
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inferred← citeshttps://doi.org/10.1007/s15033-019-1232-8openalex-snapshot
Spezifische Immuntherapie bei Allergien
inferred← citeshttps://doi.org/10.1007/s15033-020-0657-4openalex-snapshot
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inferred← citeshttps://doi.org/10.1007/s40521-017-0110-zopenalex-snapshot
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inferred← citeshttps://doi.org/10.1007/s40521-018-0192-2openalex-snapshot
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inferred← citeshttps://doi.org/10.1007/s40521-020-00245-zopenalex-snapshot
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inferred← citeshttps://doi.org/10.1007/s40629-021-00163-9openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/b978-0-08-100596-5.22845-xopenalex-snapshot
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inferred← citeshttps://doi.org/10.1016/b978-0-12-801238-3.11500-4openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/b978-0-12-809324-5.22285-2openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/b978-0-12-809633-8.21044-3openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/b978-0-12-810541-2.00005-1openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/b978-0-12-811073-7.00002-7openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/b978-0-12-813471-9.00011-6openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/b978-0-12-813471-9.00017-7openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/b978-0-12-813471-9.00045-1openalex-snapshot
Prevention of Asthma
inferred← citeshttps://doi.org/10.1016/b978-0-12-814603-3.00009-4openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/b978-0-12-818731-9.00200-7openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/b978-0-12-823008-4.00019-6openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/b978-0-12-824465-4.00252-0openalex-snapshot
The Immunobiology of Asthma
inferred← citeshttps://doi.org/10.1016/b978-0-323-44887-1.00042-0openalex-snapshot
The Epidemiology of Asthma
inferred← citeshttps://doi.org/10.1016/b978-0-323-44887-1.00043-2openalex-snapshot
The Immunopathogenesis of Asthma
inferred← citeshttps://doi.org/10.1016/b978-0-323-80912-2.00003-2openalex-snapshot
Epidemiology of Allergic Diseases
inferred← citeshttps://doi.org/10.1016/b978-0-323-85419-1.00006-2openalex-snapshot
Airway microbiome and asthma
inferred← citeshttps://doi.org/10.1016/b978-0-323-91387-4.00003-xopenalex-snapshot
Host, Genetic, and Environmental Influences on the Gut Microbiota
inferred← citeshttps://doi.org/10.1016/b978-0-323-95488-4.00048-6openalex-snapshot
Chemical- and Drug-Induced Asthma
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Inflammatory Cells of the Lung: Lymphoid Cells
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Understanding risk factors for developing food allergy: What do epidemiological data tell us?
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Airway sensitization to foods
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Role of domestic animal exposure
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Microbiome engineering to improve animal health
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Advances in asthma genetics
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The human microbiome
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A 21st century view of infection control in everyday settings: Moving from the Germ Theory of Disease to the Microbial Theory of Health
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Strategic Outlook toward 2030: Japan's research for allergy and immunology – Secondary publication
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Early environmental determinants of childhood asthma
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Childhood asthma as a life-course disease: Recent advances, environmental determinants, and biomarkers
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Microbiome in the primary prevention of allergic diseases and bronchial asthma
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Prevalence, risk factors, and clinical outcomes of atopic and nonatopic asthma among rural children
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The atopic march
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The environment and food allergy
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The Amish have decreased asthma and allergic diseases compared with old order Mennonites
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The microbiome in asthma
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The “envirome” and what the practitioner needs to know about it
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Nature and nurture
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Food allergy, breastfeeding, and introduction of complementary foods in the New York Old Order Mennonite Community
inferred← citeshttps://doi.org/10.1016/j.anai.2020.05.016openalex-snapshot
Outside-in hypothesis revisited
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The origins of allergy from a systems approach
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One march, many paths: Insights into allergic march trajectories
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Pathogenesis-based application of biologics for chronic rhinosinusitis: Current and future perspectives
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The Microbiome and Asthma
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Microbioma y asma
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Hygiene Hypothesis in Asthma Development: Is Hygiene to Blame?
inferred← citeshttps://doi.org/10.1016/j.autrev.2019.102430openalex-snapshot
Multiple sclerosis, the microbiome, TLR2, and the hygiene hypothesis
inferred← citeshttps://doi.org/10.1016/j.banm.2019.07.007openalex-snapshot
Discussion suite à la communication : « Protection contre l’allergie par l’environnement de la ferme : en 15 ans, qu’avons-nous appris de la cohorte européenne PASTURE ? »
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Pawsitive impact: How pet contact ameliorates adult inflammatory stress responses in individuals raised in an urban environment
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Immune dysregulation in depression: Evidence from genome-wide association
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Human exposure to indoor air pollutants in sleep microenvironments: A literature review
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Ten questions concerning the built environment and mental health
inferred← citeshttps://doi.org/10.1016/j.cca.2021.09.006openalex-snapshot
GLCCI1 gene body methylation in peripheral blood is associated with asthma and asthma severity
inferred← citeshttps://doi.org/10.1016/j.ccm.2018.10.006openalex-snapshot
Microbiome in Mechanisms of Asthma
inferred← citeshttps://doi.org/10.1016/j.ccm.2018.10.008openalex-snapshot
Life Cycle of Childhood Asthma
inferred← citeshttps://doi.org/10.1016/j.ccm.2018.10.009openalex-snapshot
Asthma over the Adult Life Course
inferred← citeshttps://doi.org/10.1016/j.ccm.2018.10.017openalex-snapshot
The Exposome and Asthma
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Indoor Microbial Exposures and Chronic Lung Disease
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The Microbiome and Pulmonary Immune Function
inferred← citeshttps://doi.org/10.1016/j.cell.2022.10.011openalex-snapshot
A distinct clade of Bifidobacterium longum in the gut of Bangladeshi children thrives during weaning
inferred← citeshttps://doi.org/10.1016/j.cellimm.2019.04.002openalex-snapshot
A20: A multifunctional tool for regulating immunity and preventing disease
inferred← citeshttps://doi.org/10.1016/j.cellimm.2023.104770openalex-snapshot
Early-immune development in asthma: A review of the literature
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Neonatal necrotizing enterocolitis attenuates adult asthma via eosinophil ferroptosis
inferred← citeshttps://doi.org/10.1016/j.celrep.2021.110051openalex-snapshot
ILC3s control airway inflammation by limiting T cell responses to allergens and microbes
inferred← citeshttps://doi.org/10.1016/j.celrep.2021.110178openalex-snapshot
GM-CSF production by non-classical monocytes controls antagonistic LPS-driven functions in allergic inflammation
inferred← citeshttps://doi.org/10.1016/j.celrep.2025.115294openalex-snapshot
Lung CD4+ resident memory T cells use airway secretory cells to stimulate and regulate onset of allergic airway neutrophilic disease
inferred← citeshttps://doi.org/10.1016/j.coi.2017.08.003openalex-snapshot
Immune development and environment: lessons from Amish and Hutterite children
inferred← citeshttps://doi.org/10.1016/j.coi.2017.10.009openalex-snapshot
Highlights in immune response, microbiome and precision medicine in allergic disease and asthma
inferred← citeshttps://doi.org/10.1016/j.coi.2018.05.006openalex-snapshot
Role of neutrophils in allergic asthma
inferred← citeshttps://doi.org/10.1016/j.coi.2018.06.007openalex-snapshot
The hygiene hypothesis: immunological mechanisms of airway tolerance
inferred← citeshttps://doi.org/10.1016/j.coi.2018.06.009openalex-snapshot
Regulation of neutrophils in type 2 immune responses
inferred← citeshttps://doi.org/10.1016/j.coi.2019.04.001openalex-snapshot
The microbiome: toward preventing allergies and asthma by nutritional intervention
inferred← citeshttps://doi.org/10.1016/j.coi.2019.08.001openalex-snapshot
How a farming environment protects from atopy
inferred← citeshttps://doi.org/10.1016/j.coi.2020.03.012openalex-snapshot
Microbiota–immune interactions in asthma pathogenesis and phenotype
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Microbiota and human allergic diseases: the company we keep
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An integrative medicine review of primary prevention of allergy in pediatrics
inferred← citeshttps://doi.org/10.1016/j.cyto.2017.09.005openalex-snapshot
Enhanced expression of PD-L1 and IFN-γ on dendritic cells is associated with BCG-induced Th2 inhibition
inferred← citeshttps://doi.org/10.1016/j.dibe.2021.100055openalex-snapshot
Differing effects of four building materials on viable bacterial communities and VOCs
inferred← citeshttps://doi.org/10.1016/j.disamonth.2019.100886openalex-snapshot
Update in Pediatric Asthma: Selected Issues
inferred← citeshttps://doi.org/10.1016/j.ebiom.2020.103186openalex-snapshot
Therapeutic efficacy of pulmonary live tuberculosis vaccines against established asthma by subverting local immune environment
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Characteristics and associated morbidities of young adults with misconceived food allergy: A cross-sectional study
inferred← citeshttps://doi.org/10.1016/j.ecoenv.2022.113900openalex-snapshot
A Placebo-controlled double-blinded test of the biodiversity hypothesis of immune-mediated diseases: Environmental microbial diversity elicits changes in cytokines and increase in T regulatory cells in young children
inferred← citeshttps://doi.org/10.1016/j.eehl.2022.09.002openalex-snapshot
Indoor microbiome and allergic diseases: From theoretical advances to prevention strategies
inferred← citeshttps://doi.org/10.1016/j.envint.2019.05.011openalex-snapshot
Can bacterial indicators of a grassy woodland restoration inform ecosystem assessment and microbiota-mediated human health?
inferred← citeshttps://doi.org/10.1016/j.envint.2019.105187openalex-snapshot
Urban-associated diseases: Candidate diseases, environmental risk factors, and a path forward
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Long-term biodiversity intervention shapes health-associated commensal microbiota among urban day-care children
inferred← citeshttps://doi.org/10.1016/j.envint.2024.108705openalex-snapshot
Urban indoor gardening enhances immune regulation and diversifies skin microbiota — A placebo-controlled double-blinded intervention study
inferred← citeshttps://doi.org/10.1016/j.envres.2017.08.023openalex-snapshot
Livestock and poultry density and childhood cancer incidence in nine states in the USA
inferred← citeshttps://doi.org/10.1016/j.envres.2018.03.028openalex-snapshot
It's not just the food you eat: Environmental factors in the development of food allergies
inferred← citeshttps://doi.org/10.1016/j.envres.2020.109847openalex-snapshot
Characterization of chronic obstructive pulmonary disease in dairy farmers
inferred← citeshttps://doi.org/10.1016/j.envres.2020.110425openalex-snapshot
Increased plant species richness associates with greater soil bacterial diversity in urban green spaces
inferred← citeshttps://doi.org/10.1016/j.envres.2021.110835openalex-snapshot
Microbial diversity in homes and the risk of allergic rhinitis and inhalant atopy in two European birth cohorts
inferred← citeshttps://doi.org/10.1016/j.envres.2023.117296openalex-snapshot
Fungal diversity in homes and asthma morbidity among school-age children in New York City
inferred← citeshttps://doi.org/10.1016/j.envres.2023.117819openalex-snapshot
Occupational farm work activities influence workers’ indoor home microbiome
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