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A Case Series of Children with Acute Hepatitis and Human Adenovirus Infection

https://doi.org/10.1056/nejmoa2206294
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/hep.22322openalex-snapshot
Simplified criteria for the diagnosis of autoimmune hepatitis†
inferredcites →https://doi.org/10.1002/hep.31487openalex-snapshot
Abnormal Liver Tests in COVID‐19: A Retrospective Observational Cohort Study of 1,827 Patients in a Major U.S. Hospital Network
inferredcites →https://doi.org/10.1002/jmv.10382openalex-snapshot
Rapid and quantitative detection of human adenovirus DNA by real‐time PCR
inferredcites →https://doi.org/10.1007/s00705-006-0842-8openalex-snapshot
Detection and sequence-based typing of human adenoviruses using sensitive universal primer sets for the hexon gene
inferredcites →https://doi.org/10.1007/s15010-013-0527-7openalex-snapshot
Fulminant hepatitis due to human adenovirus
inferredcites →https://doi.org/10.1016/b978-0-12-801238-3.00086-6openalex-snapshot
Adenoviruses
inferredcites →https://doi.org/10.1016/j.humpath.2007.02.012openalex-snapshot
Histopathologic, immunohistochemical, and polymerase chain reaction assays in the study of cases with fatal sporadic myocarditis
inferredcites →https://doi.org/10.1016/j.jpeds.2005.12.051openalex-snapshot
Acute liver failure in children: The first 348 patients in the pediatric acute liver failure study group
inferredcites →https://doi.org/10.1016/s0022-3476(05)80593-1openalex-snapshot
Acute adenovirus hepatitis in liver transplant recipients
inferredcites →https://doi.org/10.1055/s-0036-1584923openalex-snapshot
Adenovirus: Epidemiology, Global Spread of Novel Serotypes, and Advances in Treatment and Prevention
inferredcites →https://doi.org/10.1056/nejmoa2206704openalex-snapshot
Clinical Spectrum of Children with Acute Hepatitis of Unknown Cause
inferredcites →https://doi.org/10.1093/infdis/jiab039openalex-snapshot
Evidence of Severe Acute Respiratory Syndrome Coronavirus 2 Replication and Tropism in the Lungs, Airways, and Vascular Endothelium of Patients With Fatal Coronavirus Disease 2019: An Autopsy Case Series
inferredcites →https://doi.org/10.1097/pas.0000000000000834openalex-snapshot
Adenovirus Hepatitis
inferredcites →https://doi.org/10.1097/pg9.0000000000000108openalex-snapshot
Acute Liver Failure in a Healthy Young Female With COVID‐19
inferredcites →https://doi.org/10.1111/liv.14887openalex-snapshot
Liver involvement in children with SARS‐COV‐2 infection: Two distinct clinical phenotypes caused by the same virus
inferredcites →https://doi.org/10.1111/tid.13496openalex-snapshot
Detection of adenovirus hepatitis and acute liver failure in allogeneic hematopoietic stem cell transplant patients
inferredcites →https://doi.org/10.1155/2016/8648190openalex-snapshot
Acute Hepatitis and Pancytopenia in Healthy Infant with Adenovirus

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Characterization of a Hepatitis Outbreak in Children, 2021 to 2022
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Adenoviruses
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Adenoviruses
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Molecular Epidemiology of Human Adenovirus Strains in Children With Acute Gastroenteritis in Tehran, Iran (2021–2022 and 2023–2024): Genetic Characterization of Adenovirus F41
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Adenovirus F41 infection and liver cytolysis in adult hematopoietic stem cell transplant recipients
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A significant outbreak of respiratory human adenovirus infections among children aged 3−6 years in Hokkaido, Japan, in 2023
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Severe hepatitis in pediatric patients: The Severe Hepatitis In Pediatric Patients (SHIPP) registry
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Coronavirus HKU1 infection and development of pediatric acute liver failure with immune dysregulation phenotype
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Adenovirus Outbreak in Pediatric Cancer Patients
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Adenoviruses
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Descriptive and Analytical Epidemiology
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(Seltene) infektiöse Hepatitiden als wichtige Differenzialdiagnose der unklaren Hepatopathie
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Long-term antigen-specific immune response by an oncolytic adenovirus encoding SP-SA-E7-4-1BBL in HPV-16 cancer model
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Uncovering the Underlying Causes of Severe Acute Hepatitis of Unknown Aetiology in Children: A Comprehensive Review
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Viral Diseases
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Infectious Diarrhea
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Neonatal Hepatitis
inferred← citeshttps://doi.org/10.1016/j.ajt.2022.10.002openalex-snapshot
Acute liver failure and unique challenges of pediatric liver transplantation amidst a worldwide cluster of adenovirus-associated hepatitis
inferred← citeshttps://doi.org/10.1016/j.antiviral.2022.105431openalex-snapshot
Filociclovir is a potent inhibitor of human adenovirus F41
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Oral USC-093, a novel homoserinamide analogue of the tyrosinamide (S)-HPMPA prodrug USC-087 has decreased nephrotoxicity while maintaining antiviral efficacy against human adenovirus infection of Syrian hamsters
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Clinical characteristics and potential biomarkers predicting disease progression in severe adenoviral pneumonia: A pediatric intensive care unit experience
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Development and implementation of assays to monitor human adenovirus F40/41 in wastewater: Trends preceding, during, and following the non-A-to-E hepatitis outbreak in Stockholm
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Update on Epidemiology and Outcomes of Infection in Pediatric Organ Transplant Recipients
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Outbreak of indeterminate acute liver failure in children with adenoviraemia – Not a new disease
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Association between adeno-associated virus 2 and severe acute hepatitis of unknown etiology in Japanese children
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Demystifying the global outbreak of severe acute hepatitis of unknown aetiology in children: A systematic review and meta-analysis
inferred← citeshttps://doi.org/10.1016/j.jpeds.2023.113439openalex-snapshot
Recent Increase in Incidence of Severe Acute Hepatitis of Unknown Etiology in Children is Associated with Infection with Adenovirus and Other Nonhepatotropic Viruses
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Clinical characteristics and phylogenetic analysis of human enteric adenovirus type 41 (HAdV-F41) from children with gastroenteritis during SARS-CoV-2 pandemic
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Adenoviruses in medicine: innocuous pathogen, predator, or partner
inferred← citeshttps://doi.org/10.1016/j.molmed.2022.11.006openalex-snapshot
Common mechanisms in pediatric acute liver failure
inferred← citeshttps://doi.org/10.1016/j.mpdhp.2026.06.008openalex-snapshot
Hepatic involvement in systemic infections
inferred← citeshttps://doi.org/10.1016/j.scitotenv.2022.159579openalex-snapshot
Detection of human adenovirus F41 in wastewater and its relationship to clinical cases of acute hepatitis of unknown aetiology
inferred← citeshttps://doi.org/10.1016/j.scitotenv.2023.165012openalex-snapshot
Measures against COVID-19 affected the spread of human enteric viruses in a Swedish community, as found when monitoring wastewater
inferred← citeshttps://doi.org/10.1016/j.scitotenv.2024.176806openalex-snapshot
Co-occurrence of adeno-associated virus 2 and human enteric adenovirus (group F) in wastewater after worldwide outbreaks of acute hepatitis of unknown etiology (AHUE)
inferred← citeshttps://doi.org/10.1016/j.transproceed.2023.08.004openalex-snapshot
Clinical Aspects and Etiologic Investigation of Pediatric Patients With Acute Liver Failure
inferred← citeshttps://doi.org/10.1016/j.virol.2025.110653openalex-snapshot
Immunoinformatics design and experimental expression of a multi-epitope vaccine simultaneously targeting AAV2 and HAdV-F41 against acute hepatitis of unknown etiology
inferred← citeshttps://doi.org/10.1016/j.ymthe.2022.08.001openalex-snapshot
AAV and hepatitis: Cause or coincidence?
inferred← citeshttps://doi.org/10.1016/s0140-6736(24)00693-7openalex-snapshot
Acute liver failure
inferred← citeshttps://doi.org/10.1016/s2211-9698(25)74852-9openalex-snapshot
Adénovirus hors gastroentérites
inferred← citeshttps://doi.org/10.1016/s2352-4642(23)00192-xopenalex-snapshot
Paediatric acute hepatitis of unknown aetiology: a national surveillance investigation in the USA during 2021 and 2022
inferred← citeshttps://doi.org/10.1016/s2352-4642(23)00215-8openalex-snapshot
Paediatric acute hepatitis of unknown aetiology: a national investigation and adenoviraemia case-control study in the UK
inferred← citeshttps://doi.org/10.1016/s2352-4642(23)00222-5openalex-snapshot
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The pattern of childhood infections during and after the COVID-19 pandemic
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Adenovirus 41 diversity in Arizona (USA) using wastewater-based epidemiology, long-range PCR, and pathogen sequencing between October 2019 and March 2020
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Label-Free Proteomics of Severe Acute Hepatitis of Unknown Origin in Children by High-Resolution Mass Spectrometry
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Severe hepatitis outbreak in children linked to AAV2 virus
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Manganese regulation of COPII condensation controls circulating lipid homeostasis
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Clinical metagenomics for diagnosis and surveillance of viral pathogens
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Adeno-associated virus 2 infection in children with non-A–E hepatitis
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Adeno-associated virus type 2 in US children with acute severe hepatitis
inferred← citeshttps://doi.org/10.1038/s41586-023-06003-wopenalex-snapshot
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Akute Hepatitis mit Adenovirus-Virämie: eine Fallserie aus den USA
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Children with Acute Hepatitis of Unknown Cause
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Acute Hepatitis in Children in 2022 — Human Adenovirus 41?
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Clinical Spectrum of Children with Acute Hepatitis of Unknown Cause
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Non-hepatotropic viral hepatitis: a narrative review
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Pathogenicity and virulence of human adenovirus F41: Possible links to severe hepatitis in children
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Current and Emerging Issues in Adeno-Associated Virus Vector-Mediated Liver-Directed Gene Therapy
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Extended persistence and thermostability of adenovirus 41 in the presence of bacteria
inferred← citeshttps://doi.org/10.1093/jpids/piad021openalex-snapshot
Etiology of Severe Acute Hepatitis in a Pediatric Transplant Center in Japan
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Decline of Pediatric Acute Hepatitis of Unknown Etiology During the Coronavirus Disease 2019 Pandemic in Japan
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Molecular phylogeny of human adenovirus type 41 lineages
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Severe acute hepatitis of unknown etiology in a large cohort of children
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Cord blood IgG for respiratory syncytial virus and subsequent infection during the COVID-19 pandemic
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Acute Hepatitis of Unknown Etiology Among Young Children
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Reply to
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Adenovirus is Not Detected in Liver Tissue From a Historical Multicenter Cohort of Children With Acute Liver Failure
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Clinicopathologic Features of Severe Acute Hepatitis Associated With Adenovirus Infection in Children
inferred← citeshttps://doi.org/10.1097/pas.0000000000002266openalex-snapshot
Clinical and Histopathologic Characteristics of Acute Severe Hepatitis Associated With Human Herpesvirus 6 Infection
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A Case of Reactivated Acute Hepatitis in a 12‐month‐old Infant With Multiviral Infection, Including SARS‐CoV‐2 and Adenovirus
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Viral Hepatitis Necessitating Liver Transplantation in Children
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Multiplex MinION sequencing suggests enteric adenovirus F41 genetic diversity comparable to pre-COVID-19 era
inferred← citeshttps://doi.org/10.1101/2022.07.19.22277425openalex-snapshot
Adeno-associated virus 2 infection in children with non-A-E hepatitis
inferred← citeshttps://doi.org/10.1101/2022.09.19.22279829openalex-snapshot
Adeno-associated virus type 2 in children from the United States with acute severe hepatitis
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Impact of sample clarification by size exclusion on virus detection and diversity in wastewater-based epidemiology
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Genomic epidemiology of Human Adenovirus F40 and F41 in Coastal Kenya: A retrospective hospital-based surveillance study (2013-2022)
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Liver abnormalities following SARS-CoV-2 infection in children under 10 years of age
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Synthesis of USC-093 and comparison with its promoiety enantiomer USC-093D against adenovirus in vitro and in a Syrian hamster model
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Vehicle Routing Optimization for Humanitarian Supply Chain: A Systematic Review of Approaches and Solutions
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Non‐A to E hepatitis in children: Detecting a novel viral epidemic during the COVID ‐19 pandemic
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Time trend of respiratory viruses before and during the COVID‐19 pandemic in severe acute respiratory virus infection in the Sultanate of Oman between 2017 and 2022
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Single‐Center Survey of Prevalence of Viruses in Pediatric Liver Explants
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Signatures of AAV-2 immunity are enriched in children with severe acute hepatitis of unknown etiology
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Replication-competent adenovirus reporters utilizing endogenous viral expression architecture
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Whole-genome sequencing of adenovirus 41 directly from wastewater using nested overlapping PCR and MinION
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Liver abnormalities following SARS-CoV-2 infection in children 1 to 10 years of age
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Global prevalence of pre-existing antibodies against human adenoviruses, surveyed from 1962-2021
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Safety Findings of Dosing Gene Therapy Vectors in NHP With Pre-existing or Treatment-Emergent Anti-capsid Antibodies
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Adenoviral fiber-knob based vaccination elicits efficient neutralizing antibodies and T cell responses against adenovirus infection
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Molecular characteristics of human adenovirus isolated from the 2024 influenza-like illness outbreaks in Suzhou City, China
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Adenovirus phagocytosis by neutrophils triggers a pro-inflammatory response
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Adenovirüsün neden olduğu akut hepatit olgusu
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Severe acute hepatitis of unknown cause in children
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Hépatite aiguë grave d’étiologie inconnue chez les enfants
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Acute Liver Failure in a Child With Adenovirus Detected by PCR in the Explanted Liver
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Clinical features and prediction of risk factors for severe adenovirus pneumonia in children
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Acute hepatitis of unknown origin in children: analysis of probable etiologies
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Severe acute hepatitis of unknown origin in children: Clinical issues of concern
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Task Force for a rapid response to an outbreak of severe acute hepatitis of unknown aetiology in children in Portugal in 2022
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The Meningitis and Encephalitis Registry of Lower Saxony, Germany (MERIN) – design and main results of circulating neurotropic pathogen surveillance, 2003 to 2023
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Insuficiencia hepática aguda por adenovirus tratada con inmunoglobulina intravenosa
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Enteric adenovirus F41 genetic diversity comparable to pre-COVID-19 era: validation of a multiplex amplicon-MinION sequencing method
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Adeno-Associated Virus 2 and Human Adenovirus F41 in Wastewater during Outbreak of Severe Acute Hepatitis in Children, Ireland
inferred← citeshttps://doi.org/10.3201/eid3002.230623openalex-snapshot
Identification of Large Adenovirus Infection Outbreak at University by Multipathogen Testing, South Carolina, USA, 2022
inferred← citeshttps://doi.org/10.3201/eid3207.260284openalex-snapshot
Adeno-Associated Virus Type 2 and Human Adenovirus Species F Type 41 Co-infection Associated with Acute Severe Hepatitis in Children, California, USA
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Hepatitis de causa desconocida en niños y su posible relación con Adenovirus serotipos 40/41 y SARS-CoV-2
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Infección por adenovirus humano como potencial causante de hepatitis en pediatría
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PSYCHOLÓGIA PRÁCE A ORGANIZÁCIE 2023
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HOMO HOMINI LUPUS. UNDESIRABLE PUBLIC BEHAVIOUR TOWARDS HEALTH PROFFESIONALS DURING THE COVID-19 PANDEMIC
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Solved the enigma of pediatric severe acute hepatitis of unknown origin?
inferred← citeshttps://doi.org/10.3389/fcimb.2026.1863975openalex-snapshot
Risk factors for hospitalization in pediatric patients with human adenovirus infection and changes in epidemiological and clinical characteristics before and after the COVID-19 pandemic in China: a multicenter retrospective study
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Case Report: HLA-DRB1 04:01 found in a child with adenovirus type 2 -linked hepatitis
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Comprehensive immune profiling and predictive modelling of paediatric acute hepatitis of unknown aetiology from a Spanish cohort
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Pediatric adenovirus pneumonia: clinical practice and current treatment
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Acute liver failure and secondary TMA-like phenomenon following SARS-CoV-2 and Mycoplasma pneumoniae co-detection in a child: a case report
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A systematic review of the proposed etiologies of the 2021–2022 outbreaks of pediatric acute hepatitis of unknown etiology
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Acute severe hepatitis outbreak in children: A perfect storm. What do we know, and what questions remain?
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Antiviral activity of Hellenia speciosa (J. Koenig) S.R. Dutta rhizome metabolites against human adenovirus: insights from molecular docking and in vitro studies
inferred← citeshttps://doi.org/10.3389/fpubh.2022.1048108openalex-snapshot
The clinical and virological features of two children's coinfections with human adenovirus type 7 and human coronavirus-229E virus
inferred← citeshttps://doi.org/10.3389/fsufs.2023.1113743openalex-snapshot
Prevalence of foodborne viruses and influenza A virus from poultry processing plants to retailed chickens
inferred← citeshttps://doi.org/10.3390/applmicrobiol4030069openalex-snapshot
Evaluation of qPCR for the Selective Detection of Enteric Adenovirus Followed by Sequence-Based Genetic Characterization of F Strains Circulating in Brazil
inferred← citeshttps://doi.org/10.3390/biomedicines12122773openalex-snapshot
Overview of the Trending Enteric Viruses and Their Pathogenesis in Intestinal Epithelial Cell Infection
inferred← citeshttps://doi.org/10.3390/ijms232415456openalex-snapshot
Lipid Droplet-Associated Proteins Perilipin 1 and 2: Molecular Markers of Steatosis and Microvesicular Steatotic Foci in Chronic Hepatitis C
inferred← citeshttps://doi.org/10.3390/microorganisms11122952openalex-snapshot
Emerging Pathogens Causing Acute Hepatitis
inferred← citeshttps://doi.org/10.3390/pathogens13121114openalex-snapshot
Clinical and Radiological Features of an Adenovirus Type 7 Outbreak in Split-Dalmatia County, Croatia, 2022–2023
inferred← citeshttps://doi.org/10.3390/v15020330openalex-snapshot
An Old Acquaintance: Could Adenoviruses Be Our Next Pandemic Threat?
inferred← citeshttps://doi.org/10.3390/v17040577openalex-snapshot
Molecular Epidemiology of Human Adenovirus from Acute Gastroenteritis Cases in Brazil After the COVID-19 Pandemic Period, 2021–2023
inferred← citeshttps://doi.org/10.3390/v18070691openalex-snapshot
Influenza as the Predominant Cause of Severe Hepatic Involvement in Children Hospitalized with Acute Respiratory Infections: A Post-COVID-19 Era Analysis
inferred← citeshttps://doi.org/10.3947/ic.2026.0033openalex-snapshot
Adenovirus Infections in Hematologic Malignancy and Hematopoietic Cell Transplant Recipients: Epidemiology, Diagnosis, and Management
inferred← citeshttps://doi.org/10.4103/jpcc.jpcc_46_24openalex-snapshot
Adenoviral infection in children admitted with severe acute respiratory infection at tertiary care hospital from North India: A case series
inferred← citeshttps://doi.org/10.4254/wjh.v15.i3.364openalex-snapshot
May 2022 acute hepatitis outbreak, is there a role for COVID-19 and other viruses?
inferred← citeshttps://doi.org/10.47300/actasidi-unicyt-2022-31openalex-snapshot
RELACIÓN ENTRE LA HEPATITIS AGUDA GRAVE DE ETIOLOGÍA DESCONOCIDA EN NIÑOS Y LOS ADENOVIRUS
inferred← citeshttps://doi.org/10.5501/wjv.v14.i3.107905openalex-snapshot
Non hepatotropic virus induced hepatitis - rising importance in a changing world
inferred← citeshttps://doi.org/10.5501/wjv.v14.i4.110435openalex-snapshot
Comparison of three pediatric studies investigating acute hepatitis of unknown etiology
inferred← citeshttps://doi.org/10.56294/sctconf2024552openalex-snapshot
Rotavirus and adenovirus in the canton of Ambato, a retrospective post-pandemic analysis
inferred← citeshttps://doi.org/10.70675/4eedfe6fz7223z4607zbbadz08b5b11a64e6openalex-snapshot
Interactions neutrophiles-adénovirus : mécanismes moléculaires impliqués et rôle physiologique
inferred← citeshttps://doi.org/10.7759/cureus.49136openalex-snapshot
Possible Donor-Derived Infection in a Pediatric Liver Transplant Patient With Granulomatous Hepatitis
inferred← citeshttps://doi.org/10.7759/cureus.58307openalex-snapshot
Distinct Patterns of Liver Chemistry Changes in Pediatric Acute Hepatitis of Unknown Origin and COVID-19 Patients: A Systematic Review
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