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The hyp-1 gene is not a limiting factor for hypericin biosynthesis in the genus Hypericum

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/pca.875openalex-snapshot

Phytochemical profiling of new and old world Hypericum (St. John's Wort) species

inferredcites →https://doi.org/10.1006/abio.1996.9916openalex-snapshot

Product Differentiation by Analysis of DNA Melting Curves during the Polymerase Chain Reaction

inferredcites →https://doi.org/10.1007/bf03030606openalex-snapshot

Chemical Constituents of SomeHypericum Species Growing in Turkey

inferredcites →https://doi.org/10.1007/s00299-006-0240-4openalex-snapshot

Expression of the hyp-1 gene in early stages of development of Hypericum perforatum L.

inferredcites →https://doi.org/10.1007/s00606-008-0099-7openalex-snapshot

Phylogeny of the eudicot order Malpighiales: analysis of a recalcitrant clade with sequences of the petD group II intron

inferredcites →https://doi.org/10.1016/0960-894x(95)00458-6openalex-snapshot

The synthesis and biological evaluation of hypericin analogs

inferredcites →https://doi.org/10.1016/j.biortech.2010.01.115openalex-snapshot

Production of adventitious roots and secondary metabolites by Hypericum perforatum L. in a bioreactor

inferredcites →https://doi.org/10.1016/j.bse.2007.09.002openalex-snapshot

Phenolic constituents of 17 Hypericum species from Turkey

inferredcites →https://doi.org/10.1016/j.jplph.2007.04.008openalex-snapshot

Molecular cloning and tissue-specific expression of two cDNAs encoding polyketide synthases from Hypericum perforatum

inferredcites →https://doi.org/10.1016/j.jsb.2009.10.008openalex-snapshot

Crystal structure of Hyp-1, a St. John’s wort protein implicated in the biosynthesis of hypericin

inferredcites →https://doi.org/10.1016/j.lfs.2005.12.027openalex-snapshot

Hyperforin: More than an antidepressant bioactive compound?

inferredcites →https://doi.org/10.1016/j.phytochem.2005.09.007openalex-snapshot

Birch PR-10c interacts with several biologically important ligands

inferredcites →https://doi.org/10.1016/j.phytochem.2009.05.012openalex-snapshot

Benzoxazinoid biosynthesis, a model for evolution of secondary metabolic pathways in plants

inferredcites →https://doi.org/10.1016/j.phytochem.2009.07.022openalex-snapshot

Positive correlations between hypericin and putative precursors detected in the quantitative secondary metabolite spectrum of Hypericum

inferredcites →https://doi.org/10.1016/s0981-9428(01)01326-2openalex-snapshot

Differential effects of light and nitrogen on production of hypericins and leaf glands in Hypericum perforatum

inferredcites →https://doi.org/10.1055/s-2006-957796openalex-snapshot

Production of Hypericin, Pseudohypericin and Flavonoids in Cell Cultures of VariousHypericumSpecies and their Chemotypes

inferredcites →https://doi.org/10.1071/fp03062openalex-snapshot

Transcriptional regulation of secondary metabolism

inferredcites →https://doi.org/10.1074/jbc.m301681200openalex-snapshot

Molecular and Biochemical Characterization of an Enzyme Responsible for the Formation of Hypericin in St. John's Wort (Hypericum perforatum L.)

inferredcites →https://doi.org/10.1078/0367-2530-00019openalex-snapshot

Ultrastructural studies on the developing secretory nodules of Hypericum perforatum

inferredcites →https://doi.org/10.1080/13880200902942436openalex-snapshot

Secondary metabolites ofHypericum scabrumandHypericum bupleuroides

inferredcites →https://doi.org/10.1093/aob/mcl169openalex-snapshot

Plant–Environment Interactions: Accumulation of Hypericin in Dark Glands of Hypericum perforatum

inferredcites →https://doi.org/10.1111/j.1399-3054.1965.tb06874.xopenalex-snapshot

Organic Growth Factor Requirements of Tobacco Tissue Cultures

inferredcites →https://doi.org/10.1111/j.1469-8137.1990.tb00427.xopenalex-snapshot

Internal secretory structures in Hypericum (Clusiaceae): H. perforatum L. and H. balearicum L.

inferredcites →https://doi.org/10.1111/j.1742-4658.2008.06576.xopenalex-snapshot

Octaketide‐producing type III polyketide synthase from Hypericum perforatum is expressed in dark glands accumulating hypericins

inferredcites →https://doi.org/10.1177/1934578x0600101211openalex-snapshot

Hypericum Perforatum L., H. Maculatum Crantz., H. Calycinum L. and H. pulchrum L.: Phytochemical and Morphological Studies

inferredcites →https://doi.org/10.1186/1471-2148-8-286openalex-snapshot

The Bet v 1 fold: an ancient, versatile scaffold for binding of large, hydrophobic ligands

inferredcites →https://doi.org/10.1385/mb:19:2:201openalex-snapshot

Isolation of High Quality RNA from Bilberry (Vaccinium myrtillus L.) Fruit

inferredcites →https://doi.org/10.2174/1381612053382287openalex-snapshot

Hypericin - The Facts About a Controversial Agent

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.1016/j.phytochem.2021.112742zenodo-depositor-declared

Phytochemical profiling of several Hypericum species identified using genetic markers

inferred← citeshttps://doi.org/10.1007/978-3-319-65079-1_7openalex-snapshot

Engineering of Secondary Metabolites in Tissue and Cell Culture of Medicinal Plants: An Alternative to Produce Beneficial Compounds Using Bioreactor Technologies

inferred← citeshttps://doi.org/10.1007/978-3-642-29974-2_17openalex-snapshot

Use of Metabolomics and Transcriptomics to Gain Insights into the Regulation and Biosynthesis of Medicinal Compounds: Hypericum as a Model

inferred← citeshttps://doi.org/10.1007/s00216-015-8682-6openalex-snapshot

Spatial chemo-profiling of hypericin and related phytochemicals in Hypericum species using MALDI-HRMS imaging

inferred← citeshttps://doi.org/10.1007/s00216-018-1384-0openalex-snapshot

Phenotyping the genus Hypericum by secondary metabolite profiling: emodin vs. skyrin, two possible key intermediates in hypericin biosynthesis

inferred← citeshttps://doi.org/10.1007/s00425-019-03310-3openalex-snapshot

Transgenic expression of Hyp-1 gene from Hypericum perforatum L. alters expression of defense-related genes and modulates recalcitrance to Agrobacterium tumefaciens

inferred← citeshttps://doi.org/10.1007/s00709-019-01448-1openalex-snapshot

Nitrogen nutrition modulates oxidative stress and metabolite production in Hypericum perforatum

inferred← citeshttps://doi.org/10.1007/s11105-016-0982-2openalex-snapshot

Differentially Expressed Genes in Hypericin-Containing Hypericum perforatum Leaf Tissues as Revealed by De Novo Assembly of RNA-Seq

inferred← citeshttps://doi.org/10.1007/s11240-013-0316-0openalex-snapshot

Stress-induced expression and structure of the putative gene hyp-1 for hypericin biosynthesis

inferred← citeshttps://doi.org/10.1007/s11240-024-02723-7openalex-snapshot

Biotechnological approaches for the production of hypericin and other important metabolites from the genus Hypericum

inferred← citeshttps://doi.org/10.1007/s11756-026-02353-8openalex-snapshot

Glyphosate affects shoot regeneration and hypericin-associated dark nodule differentiation in selected Hypericum species in vitro

inferred← citeshttps://doi.org/10.1007/s12649-021-01443-9openalex-snapshot

Natural Quinone Dyes: A Review on Structure, Extraction Techniques, Analysis and Application Potential

inferred← citeshttps://doi.org/10.1016/j.biotechadv.2023.108104openalex-snapshot

Recent advances in the identification of biosynthetic genes and gene clusters of the polyketide-derived pathways for anthraquinone biosynthesis and biotechnological applications

inferred← citeshttps://doi.org/10.1016/j.crvi.2014.08.002openalex-snapshot

Hypericin biosynthesis in Hypericum hookerianum Wight and Arn: Investigation on biochemical pathways using metabolite inhibitors and suppression subtractive hybridization

inferred← citeshttps://doi.org/10.1016/j.indcrop.2022.114876openalex-snapshot

Understanding the hypericin biosynthesis via reversible inhibition of dark gland development in Hypericum perforatum L.

inferred← citeshttps://doi.org/10.1016/j.jhazmat.2014.12.060openalex-snapshot

Lanthanum rather than cadmium induces oxidative stress and metabolite changes in Hypericum perforatum

inferred← citeshttps://doi.org/10.1016/j.jpba.2018.03.048openalex-snapshot

Methodological aspects of biologically active compounds quantification in the genus Hypericum

inferred← citeshttps://doi.org/10.1016/j.plaphy.2012.11.019openalex-snapshot

PAL inhibitor evokes different responses in two Hypericum species

inferred← citeshttps://doi.org/10.1016/s1875-5364(14)60014-5openalex-snapshot

Hypericin: chemical synthesis and biosynthesis

inferred← citeshttps://doi.org/10.1055/a-1130-4703openalex-snapshot

Isolation, Characterization and Targeted Metabolic Evaluation of Endophytic Fungi Harbored in 14 Seed-Derived Hypericum Species

inferred← citeshttps://doi.org/10.1080/14786419.2026.2655941openalex-snapshot

Targeted HPLC and LC-MS profiling of anthraquinones: Linking to hypericin biosynthesis in Hypericum spp.

inferred← citeshttps://doi.org/10.1080/15422119.2020.1797792openalex-snapshot

Hypericin: Source, Determination, Separation, and Properties

inferred← citeshttps://doi.org/10.1111/febs.12114openalex-snapshot

Structural and functional aspects of PR ‐10 proteins

inferred← citeshttps://doi.org/10.1111/jphp.12782openalex-snapshot

Chemometric evaluation of hypericin and related phytochemicals in 17 in vitro cultured Hypericum species, hairy root cultures and hairy root-derived transgenic plants

inferred← citeshttps://doi.org/10.1111/ppl.12063openalex-snapshot

Identification and biosynthesis of acylphloroglucinols in Hypericum gentianoides

inferred← citeshttps://doi.org/10.1177/1934578x1701201140openalex-snapshot

Comparative Analysis of Phenolic Compounds in Seven Hypericum Species and Their Antioxidant Properties

inferred← citeshttps://doi.org/10.1186/s12864-024-10475-zopenalex-snapshot

In silico prediction of polyketide biosynthetic gene clusters in the genomes of Hypericum-borne endophytic fungi

inferred← citeshttps://doi.org/10.14232/phd.10653openalex-snapshot

Bioprospecting and biodiversity investigations of endophytic fungi isolated from medicinal plants and mosses

inferred← citeshttps://doi.org/10.14258/jcprm.2016031273openalex-snapshot

МАСС-СПЕКТРОМЕТРИЯ С ЛАЗЕРНОЙ ДЕСОРБЦИЕЙ/ИОНИЗАЦИЕЙ ДЛЯ СРАВНИТЕЛЬНОЙ ОЦЕНКИ СОДЕРЖАНИЯ ГИПЕРИЦИНА, ПСЕВДОГИПЕРИЦИНА И ГИПЕРФОРИНА В КУЛЬТУРНОМ И ДИКОРАСТУЩЕМ HYPERICUM PERFORATUM L IN VIVO И IN VITRO

inferred← citeshttps://doi.org/10.21203/rs.3.rs-445326/v1openalex-snapshot

Variation in phytochemical properties and expression of key genes involved in biosynthesis of hypericin using nano-capsulated and normal hormones in Hypericum perforatum L

inferred← citeshttps://doi.org/10.2174/0115680266330142250224101958openalex-snapshot

Diverse Therapeutic Potentials of Hypericin: An In-Depth Review

inferred← citeshttps://doi.org/10.3389/fpls.2016.00526openalex-snapshot

Molecular Cloning and Expression Analysis of hyp-1 Type PR-10 Family Genes in Hypericum perforatum

inferred← citeshttps://doi.org/10.3389/fpls.2016.00879openalex-snapshot

A Perspective on Hypericum perforatum Genetic Transformation

inferred← citeshttps://doi.org/10.3389/fpls.2016.01039openalex-snapshot

Comparative Transcriptome Reconstruction of Four Hypericum Species Focused on Hypericin Biosynthesis

inferred← citeshttps://doi.org/10.3390/genes11101210openalex-snapshot

The Biochemical and Genetic Basis for the Biosynthesis of Bioactive Compounds in Hypericum perforatum L., One of the Largest Medicinal Crops in Europe

inferred← citeshttps://doi.org/10.3390/molecules25173964openalex-snapshot

MALDI-HRMS Imaging Maps the Localization of Skyrin, the Precursor of Hypericin, and Pathway Intermediates in Leaves of Hypericum Species

inferred← citeshttps://doi.org/10.3390/molecules26082294openalex-snapshot

Physiological and Transcriptomic Analysis Provide Insight into Low Temperature Enhancing Hypericin Biosynthesis in Hypericum perforatum

inferred← citeshttps://doi.org/10.48130/mpb-0024-0027openalex-snapshot

Secondary metabolites of medicinal use in Hypericum spp.: a rich history and a promising future

inferred← citeshttps://doi.org/10.52547/yujs.9.1.59openalex-snapshot

The first in vitro study of seed dormancy breakage in Iranian populations of St. John’s Wort (Hypericum perforatum) with different geographical origins

inferred← citeshttps://doi.org/10.6084/m9.figshare.26729200openalex-snapshot

Additional file 1 of In silico prediction of polyketide biosynthetic gene clusters in the genomes of Hypericum-borne endophytic fungi

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