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Phosphodiesterase 4D is required for β 2 adrenoceptor subtype-specific signaling in cardiac myocytes

https://doi.org/10.1073/pnas.0405263102
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1 of the 35 references listed on this page is in the Retraction Watch database as retracted (export 2026-10-28): 10.1073/pnas.262787199 (notice 2022-04-26).

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1006/jmcc.1997.0544openalex-snapshot
Altered Expression of PDE1 and PDE4 Cyclic Nucleotide Phosphodiesterase Isoforms in 7-oxo-prostacyclin-preconditioned Rat Heart
inferredcites →https://doi.org/10.1016/s0022-2828(87)80574-6openalex-snapshot
Subclasses of cyclic AMP phosphodiesterase in cardiac muscle
inferredcites →https://doi.org/10.1016/s0026-895x(25)09146-1openalex-snapshot
Beta 1- and beta 2-adrenergic receptors display subtype-selective coupling to Gs.
inferredcites →https://doi.org/10.1016/s0026-895x(25)10404-5openalex-snapshot
LY195115: a potent, selective inhibitor of cyclic nucleotide phosphodiesterase located in the sarcoplasmic reticulum.
inferredcites →https://doi.org/10.1016/s0026-895x(25)10513-0openalex-snapshot
Activation and selective inhibition of a cyclic AMP-specific phosphodiesterase, PDE-4D3.
inferredcites →https://doi.org/10.1016/s0960-9822(00)00419-xopenalex-snapshot
Assembly of an A kinase-anchoring protein–β 2 -adrenergic receptor complex facilitates receptor phosphorylation and signaling
inferredcites →https://doi.org/10.1021/bi00778a018openalex-snapshot
Multiple cyclic nucleotide phosphodiesterase activities from rat brain
inferredcites →https://doi.org/10.1021/bi00800a014openalex-snapshot
Membrane formation in Tetrahymena pyriformis. 4. Lipid composition and biochemical properties of Tetrahymena pyriformis membrane systems
inferredcites →https://doi.org/10.1038/31255openalex-snapshot
A family of hyperpolarization-activated mammalian cation channels
inferredcites →https://doi.org/10.1038/sj.bjp.0702506openalex-snapshot
Characterization of the cyclic nucleotide phosphodiesterase subtypes involved in the regulation of the L‐type Ca2+ current in rat ventricular myocytes
inferredcites →https://doi.org/10.1073/pnas.122041599openalex-snapshot
Induction of the cyclic nucleotide phosphodiesterase PDE4B is essential for LPS-activated TNF-α responses
inferredcites →https://doi.org/10.1073/pnas.221381398openalex-snapshot
A uniform extracellular stimulus triggers distinct cAMP signals in different compartments of a simple cell
inferredcites →https://doi.org/10.1073/pnas.262787199openalex-snapshot
RETRACTED: β-Arrestin-mediated PDE4 cAMP phosphodiesterase recruitment regulates β-adrenoceptor switching from G s to G i
inferredcites →https://doi.org/10.1073/pnas.93.1.295openalex-snapshot
cAMP compartmentation is responsible for a local activation of cardiac Ca2+ channels by beta-adrenergic agonists.
inferredcites →https://doi.org/10.1073/pnas.96.21.11998openalex-snapshot
Impaired growth and fertility of cAMP-specific phosphodiesterase PDE4D-deficient mice
inferredcites →https://doi.org/10.1074/jbc.271.28.16526openalex-snapshot
Phosphorylation and Activation of a cAMP-specific Phosphodiesterase by the cAMP-dependent Protein Kinase
inferredcites →https://doi.org/10.1074/jbc.m006546200openalex-snapshot
Myomegalin Is a Novel Protein of the Golgi/Centrosome That Interacts with a Cyclic Nucleotide Phosphodiesterase
inferredcites →https://doi.org/10.1074/jbc.m006951200openalex-snapshot
Differential Targeting of β-Adrenergic Receptor Subtypes and Adenylyl Cyclase to Cardiomyocyte Caveolae
inferredcites →https://doi.org/10.1074/jbc.m009130200openalex-snapshot
Regulation of Membrane Targeting of the G Protein-coupled Receptor Kinase 2 by Protein Kinase A and Its Anchoring Protein AKAP79
inferredcites →https://doi.org/10.1074/jbc.m105348200openalex-snapshot
Receptor Number and Caveolar Co-localization Determine Receptor Coupling Efficiency to Adenylyl Cyclase
inferredcites →https://doi.org/10.1074/jbc.m201644200openalex-snapshot
Caveolar Localization Dictates Physiologic Signaling of β2-Adrenoceptors in Neonatal Cardiac Myocytes
inferredcites →https://doi.org/10.1074/jbc.m909757199openalex-snapshot
Interaction with β-Arrestin Determines the Difference in Internalization Behavior between β1- and β2-Adrenergic Receptors
inferredcites →https://doi.org/10.1074/jbc.r200029200openalex-snapshot
Cyclic AMP-specific PDE4 Phosphodiesterases as Critical Components of Cyclic AMP Signaling
inferredcites →https://doi.org/10.1085/jgp.116.2.147openalex-snapshot
Cyclic Nucleotide–Gated Channels Colocalize with Adenylyl Cyclase in Regions of Restricted Camp Diffusion
inferredcites →https://doi.org/10.1093/emboj/20.8.1921openalex-snapshot
mAKAP assembles a protein kinase A/PDE4 phosphodiesterase cAMP signaling module
inferredcites →https://doi.org/10.1124/mol.62.2.193openalex-snapshot
Contributions of Protein Kinase A Anchoring Proteins to Compartmentation of cAMP Signaling in the Heart
inferredcites →https://doi.org/10.1126/science.1069982openalex-snapshot
Discrete Microdomains with High Concentration of cAMP in Stimulated Rat Neonatal Cardiac Myocytes
inferredcites →https://doi.org/10.1126/science.1074683openalex-snapshot
Targeting of Cyclic AMP Degradation to β 2 -Adrenergic Receptors by β-Arrestins
inferredcites →https://doi.org/10.1126/science.293.5527.98openalex-snapshot
A β 2 Adrenergic Receptor Signaling Complex Assembled with the Ca 2+ Channel Ca v 1.2
inferredcites →https://doi.org/10.1126/stke.2003.204.pe44openalex-snapshot
PDE4: Arrested at the Border
inferredcites →https://doi.org/10.1146/annurev.pharmtox.41.1.751openalex-snapshot
Compartmentation of G Protein-Coupled Signaling Pathways in Cardiac Myocytes
inferredcites →https://doi.org/10.1161/01.res.0000102042.83024.caopenalex-snapshot
What Is the Role of β-Adrenergic Signaling in Heart Failure?
inferredcites →https://doi.org/10.1172/jci115272openalex-snapshot
Sarcoplasmic reticulum-associated cyclic adenosine 5'-monophosphate phosphodiesterase activity in normal and failing human hearts.
inferredcites →https://doi.org/10.1210/edrv-16-3-370openalex-snapshot
Recent Progress in Understanding the Hormonal Regulation of Phosphodiesterases
inferredcites →https://doi.org/10.1517/13543784.4.11.1081openalex-snapshot
Section Review: Cardiovascular & Renal: Cyclic nucleotide phosphodiesterases as therapeutic targets in cardiovascular diseases

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.4636708openalex-extracted
Loss Of Beta2-Adrenoceptor Triggers Ca v1.2-CaNKII-Dependent Inflammation and Fibrosis in the Heart
inferred← citeshttps://doi.org/10.1002/9781118185537.ch1openalex-snapshot
cAMP‐Specific Phosphodiesterases: Modulation, Inhibition, and Activation
inferred← citeshttps://doi.org/10.1002/humu.24265openalex-snapshot
Epistatic interaction of PDE4DIP and DES mutations in familial atrial fibrillation with slow conduction
inferred← citeshttps://doi.org/10.1007/978-3-319-54579-0_2openalex-snapshot
Membrane Microdomains and cAMP Compartmentation in Cardiac Myocytes
inferred← citeshttps://doi.org/10.1007/978-3-319-54579-0_6openalex-snapshot
Cyclic Nucleotide Phosphodiesterases and Compartmentation in Normal and Diseased Heart
inferred← citeshttps://doi.org/10.1007/978-3-319-96649-6_4openalex-snapshot
Ergotropic Effect in Cardiac Tissue After Electromagnetic and β-Adrenergic Stimulus
inferred← citeshttps://doi.org/10.1007/978-3-540-72843-6_13openalex-snapshot
Scaffolding Proteins in Cardiac Myocytes
inferred← citeshttps://doi.org/10.1007/978-3-540-72843-6_6openalex-snapshot
PDE4 Associates with Different Scaffolding Proteins: Modulating Interactions as Treatment for Certain Diseases
inferred← citeshttps://doi.org/10.1007/s00210-006-0119-5openalex-snapshot
Cilostamide potentiates more the positive inotropic effects of (−)-adrenaline through β2-adrenoceptors than the effects of (−)-noradrenaline through β1-adrenoceptors in human atrial myocardium
inferred← citeshttps://doi.org/10.1007/s00210-013-0855-2openalex-snapshot
Influence of phosphodiesterases and cGMP on cAMP generation and on phosphorylation of phospholamban and troponin I by 5-HT4 receptor activation in porcine left atrium
inferred← citeshttps://doi.org/10.1007/s00395-010-0138-8openalex-snapshot
Conserved expression and functions of PDE4 in rodent and human heart
inferred← citeshttps://doi.org/10.1007/s00424-013-1280-6openalex-snapshot
Compartmentalization of cyclic nucleotide signaling: a question of when, where, and why?
inferred← citeshttps://doi.org/10.1007/s10557-007-6014-6openalex-snapshot
Myocardial Phosphodiesterases and Regulation of Cardiac Contractility in Health and Cardiac Disease
inferred← citeshttps://doi.org/10.1016/b978-0-12-374145-5.00195-9openalex-snapshot
Compartmentation of cAMP in Cardiomyocytes
inferred← citeshttps://doi.org/10.1016/j.cbpa.2009.07.009openalex-snapshot
Fluorescent biosensors for real-time tracking of post-translational modification dynamics
inferred← citeshttps://doi.org/10.1016/j.cell.2005.07.030openalex-snapshot
Phosphodiesterase 4D Deficiency in the Ryanodine-Receptor Complex Promotes Heart Failure and Arrhythmias
inferred← citeshttps://doi.org/10.1016/j.cellsig.2015.11.001openalex-snapshot
PDE4D phosphorylation: A coincidence detector integrating multiple signaling pathways
inferred← citeshttps://doi.org/10.1016/j.cellsig.2022.110322openalex-snapshot
PDE4DIP in health and diseases
inferred← citeshttps://doi.org/10.1016/j.coph.2011.10.017openalex-snapshot
Regulation of murine cardiac function by phosphodiesterases type 3 and 4
inferred← citeshttps://doi.org/10.1016/j.ejphar.2012.02.018openalex-snapshot
MRP4 and CFTR in the regulation of cAMP and β-adrenergic contraction in cardiac myocytes
inferred← citeshttps://doi.org/10.1016/j.febslet.2005.03.089openalex-snapshot
Compartmentalisation of phosphodiesterases and protein kinase A: opposites attract
inferred← citeshttps://doi.org/10.1016/j.jns.2015.11.010openalex-snapshot
Phosphodiesterase4D (PDE4D) — A risk factor for atrial fibrillation and stroke?
inferred← citeshttps://doi.org/10.1016/j.lfs.2006.01.010openalex-snapshot
Increasing synaptic noradrenaline, serotonin and histamine enhances in vivo binding of phosphodiesterase-4 inhibitor (R)-[11C]rolipram in rat brain, lung and heart
inferred← citeshttps://doi.org/10.1016/j.lfs.2006.06.020openalex-snapshot
Phosphodiesterase 4 inhibitors modulate β2-adrenoceptor agonist-induced human airway hyperresponsiveness
inferred← citeshttps://doi.org/10.1016/j.neuint.2011.08.012openalex-snapshot
Combined anti-inflammatory effects of β2-adrenergic agonists and PDE4 inhibitors on astrocytes by upregulation of intracellular cAMP
inferred← citeshttps://doi.org/10.1016/j.neulet.2005.03.062openalex-snapshot
Up-regulation of M1 muscarinic receptors expressed in CHOm1 cells by panaxynol via cAMP pathway
inferred← citeshttps://doi.org/10.1016/j.neuropharm.2008.07.010openalex-snapshot
Effects of serotonin in failing cardiac ventricle: Signalling mechanisms and potential therapeutic implications
inferred← citeshttps://doi.org/10.1016/j.nucmedbio.2006.10.002openalex-snapshot
In vivo selective binding of (R)-[11C]rolipram to phosphodiesterase-4 provides the basis for studying intracellular cAMP signaling in the myocardium and other peripheral tissues
inferred← citeshttps://doi.org/10.1016/j.tcm.2013.02.001openalex-snapshot
Compartmentalization of β-adrenergic signals in cardiomyocytes
inferred← citeshttps://doi.org/10.1016/j.tips.2006.04.009openalex-snapshot
Subtype-specific α1- and β-adrenoceptor signaling in the heart
inferred← citeshttps://doi.org/10.1016/j.yjmcc.2011.07.007openalex-snapshot
Caveolae create local signalling domains through their distinct protein content, lipid profile and morphology
inferred← citeshttps://doi.org/10.1016/j.yjmcc.2011.08.016openalex-snapshot
PDEs create local domains of cAMP signaling
inferred← citeshttps://doi.org/10.1016/j.yjmcc.2016.07.004openalex-snapshot
β-Adrenergic response is counteracted by extremely-low-frequency pulsed electromagnetic fields in beating cardiomyocytes
inferred← citeshttps://doi.org/10.1016/s1359-6446(05)03622-6openalex-snapshot
Keynote review: Phosphodiesterase-4 as a therapeutic target
inferred← citeshttps://doi.org/10.1016/s1734-1140(10)70303-0openalex-snapshot
Regulation of cAMP by phosphodiesterases in erythrocytes
inferred← citeshttps://doi.org/10.1038/aps.2008.1openalex-snapshot
Pivotal effects of phosphodiesterase inhibitors on myocyte contractility and viability in normal and ischemic hearts
inferred← citeshttps://doi.org/10.1038/bjp.2008.339openalex-snapshot
5‐HT4‐elicited positive inotropic response is mediated by cAMP and regulated by PDE3 in failing rat and human cardiac ventricles
inferred← citeshttps://doi.org/10.1038/mp.a000104.01openalex-snapshot
Phosphodiesterase 4A, cAMP specific
inferred← citeshttps://doi.org/10.1038/mp.a000105.01openalex-snapshot
Phosphodiesterase 4B, cAMP specific
inferred← citeshttps://doi.org/10.1038/sj.bjp.0707631openalex-snapshot
Phosphodiesterase‐4 blunts inotropism and arrhythmias but not sinoatrial tachycardia of (−)‐adrenaline mediated through mouse cardiac β 1 ‐adrenoceptors
inferred← citeshttps://doi.org/10.1038/sj.emboj.7601968openalex-snapshot
Signaling from β1‐ and β2‐adrenergic receptors is defined by differential interactions with PDE4
inferred← citeshttps://doi.org/10.1042/bj20051560openalex-snapshot
Phosphodiesterase-4 influences the PKA phosphorylation status and membrane translocation of G-protein receptor kinase 2 (GRK2) in HEK-293β2 cells and cardiac myocytes
inferred← citeshttps://doi.org/10.1051/jbio/2012003openalex-snapshot
Rôle des phosphodiestérases des nucléotides cycliques dans la compartimentation subcellulaire de l’AMP cyclique des myocytes cardiaques
inferred← citeshttps://doi.org/10.1053/j.sane.2006.11.002openalex-snapshot
Impact of phosphodiesterase 4D on cardiac β2 adrenergic receptor signaling
inferred← citeshttps://doi.org/10.1073/pnas.0704257104openalex-snapshot
Quantification of dynamic protein complexes using Renilla luciferase fragment complementation applied to protein kinase A activities in vivo
inferred← citeshttps://doi.org/10.1074/jbc.m109.020388openalex-snapshot
Differential Association of Phosphodiesterase 4D Isoforms with β2-Adrenoceptor in Cardiac Myocytes
inferred← citeshttps://doi.org/10.1074/jbc.m113.542589openalex-snapshot
A Long Lasting β1 Adrenergic Receptor Stimulation of cAMP/Protein Kinase A (PKA) Signal in Cardiac Myocytes
inferred← citeshttps://doi.org/10.1074/jbc.m803306200openalex-snapshot
Critical Role of PDE4D in β2-Adrenoceptor-dependent cAMP Signaling in Mouse Embryonic Fibroblasts
inferred← citeshttps://doi.org/10.1083/jcb.200604167openalex-snapshot
Organization of β-adrenoceptor signaling compartments by sympathetic innervation of cardiac myocytes
inferred← citeshttps://doi.org/10.1085/jgp.200709881openalex-snapshot
Roles of GRK and PDE4 Activities in the Regulation of β2 Adrenergic Signaling
inferred← citeshttps://doi.org/10.1093/cvr/cvad138openalex-snapshot
PDE4D mediates impaired β-adrenergic receptor signalling in the sinoatrial node in mice with hypertensive heart disease
inferred← citeshttps://doi.org/10.1093/cvr/cvu029openalex-snapshot
Control of cytoplasmic and nuclear protein kinase A by phosphodiesterases and phosphatases in cardiac myocytes
inferred← citeshttps://doi.org/10.1093/cvr/cvv123openalex-snapshot
Inhibition of type 5 phosphodiesterase counteracts β2-adrenergic signalling in beating cardiomyocytes
inferred← citeshttps://doi.org/10.1096/fj.10-156661openalex-snapshot
Binding of amyloid β peptide to β 2 adrenergic receptor induces PKA‐dependent AMPA receptor hyperactivity
inferred← citeshttps://doi.org/10.1096/fj.201800688rropenalex-snapshot
Hyperinsulinemia promotes heterologous desensitization of β 2 adrenergic receptor in airway smooth muscle in obesity
inferred← citeshttps://doi.org/10.1097/fjc.0000000000000481openalex-snapshot
Cross-Talk Between Insulin Signaling and G Protein–Coupled Receptors
inferred← citeshttps://doi.org/10.1097/fjc.0000000000001324openalex-snapshot
Subcellular β-Adrenergic Receptor Signaling in Cardiac Physiology and Disease
inferred← citeshttps://doi.org/10.1098/rstb.2022.0172openalex-snapshot
Compartmentalized cAMP signalling and control of cardiac rhythm
inferred← citeshttps://doi.org/10.1109/embc.2013.6609635openalex-snapshot
Effects of the hydrostatic pressure in in vitro beating cardiac syncytia in terms of kinematics (kinetic energy and beat frequency) and syncytia geometrical-functional classification
inferred← citeshttps://doi.org/10.1111/bph.15382openalex-snapshot
Compartmentation of β2‐adrenoceptor stimulated cAMP responses by phosphodiesterase types 2 and 3 in cardiac ventricular myocytes
inferred← citeshttps://doi.org/10.1111/j.1476-5381.2010.00677.xopenalex-snapshot
β‐Adrenoceptor stimulation potentiates insulin‐stimulated PKB phosphorylation in rat cardiomyocytes via cAMP and PKA
inferred← citeshttps://doi.org/10.1113/jphysiol.2010.188334openalex-snapshot
Cardiomyocytes with disrupted CFTR function require CaMKII and Ca 2+ ‐activated Cl − channel activity to maintain contraction rate
inferred← citeshttps://doi.org/10.1124/mol.107.037747openalex-snapshot
N-Ethylmaleimide-Sensitive Factor Regulates β2 Adrenoceptor Trafficking and Signaling in Cardiomyocytes
inferred← citeshttps://doi.org/10.1124/mol.108.049718openalex-snapshot
Phosphodiesterase 4 and Phosphatase 2A Differentially Regulate cAMP/Protein Kinase A Signaling for Cardiac Myocyte Contraction under Stimulation of β1 Adrenergic Receptor
inferred← citeshttps://doi.org/10.1124/mol.110.064444openalex-snapshot
Equilibrium between Adenylyl Cyclase and Phosphodiesterase Patterns Adrenergic Agonist Dose-Dependent Spatiotemporal cAMP/Protein Kinase A Activities in Cardiomyocytes
inferred← citeshttps://doi.org/10.1124/pr.58.3.5openalex-snapshot
Cyclic Nucleotide Phosphodiesterases: Molecular Regulation to Clinical Use
inferred← citeshttps://doi.org/10.1126/scisignal.ade3380openalex-snapshot
Arrestin-dependent nuclear export of phosphodiesterase 4D promotes GPCR-induced nuclear cAMP signaling required for learning and memory
inferred← citeshttps://doi.org/10.1134/s1068162011060148openalex-snapshot
Genes targets identification of 5-amino-exo-3-azatricyclo[5.2.1.02,6]decane-4-one in an in vivo model of arrhythmia
inferred← citeshttps://doi.org/10.1146/annurev-pharmtox-010716-104756openalex-snapshot
Nanodomain Regulation of Cardiac Cyclic Nucleotide Signaling by Phosphodiesterases
inferred← citeshttps://doi.org/10.1146/annurev.biochem.76.060305.150444openalex-snapshot
Biochemistry and Physiology of Cyclic Nucleotide Phosphodiesterases: Essential Components in Cyclic Nucleotide Signaling
inferred← citeshttps://doi.org/10.1152/ajpcell.00121.2006openalex-snapshot
Cellular mechanisms underlying prostaglandin-induced transient cAMP signals near the plasma membrane of HEK-293 cells
inferred← citeshttps://doi.org/10.1152/ajpheart.00975.2009openalex-snapshot
Protein kinases A and C regulate receptor-mediated increases in cAMP in rabbit erythrocytes
inferred← citeshttps://doi.org/10.1152/ajpheart.01226.2008openalex-snapshot
Iloprost- and isoproterenol-induced increases in cAMP are regulated by different phosphodiesterases in erythrocytes of both rabbits and humans
inferred← citeshttps://doi.org/10.1152/physrev.00015.2023openalex-snapshot
Phosphodiesterase in heart and vessels: from physiology to diseases
inferred← citeshttps://doi.org/10.1152/physrev.00029.2007openalex-snapshot
Supramolecular Assemblies and Localized Regulation of Voltage-Gated Ion Channels
inferred← citeshttps://doi.org/10.1155/2014/581738openalex-snapshot
Effects of InactivatedBordetella pertussison Phosphodiesterase in the Lung of Ovalbumin Sensitized and Challenged Rats
inferred← citeshttps://doi.org/10.1155/2015/542105openalex-snapshot
Modulation of the Cardiomyocyte Contraction inside a Hydrostatic Pressure Bioreactor:In VitroVerification of the Frank-Starling Law
inferred← citeshttps://doi.org/10.1155/2017/4204085openalex-snapshot
Model of Murine Ventricular Cardiac Tissue forIn VitroKinematic-Dynamic Studies of Electromagnetic andβ-Adrenergic Stimulation
inferred← citeshttps://doi.org/10.1159/000363646openalex-snapshot
Ischemic Preconditioning Inhibits Mitochondrial Permeability Transition Pore Opening through the PTEN/PDE4 Signaling Pathway
inferred← citeshttps://doi.org/10.1161/01.res.0000218493.09370.8eopenalex-snapshot
A Specific Pattern of Phosphodiesterases Controls the cAMP Signals Generated by Different G s -Coupled Receptors in Adult Rat Ventricular Myocytes
inferred← citeshttps://doi.org/10.1161/01.res.0000246118.98832.04openalex-snapshot
Compartmentation of Cyclic Nucleotide Signaling in the Heart
inferred← citeshttps://doi.org/10.1161/01.res.0000258451.44949.d7openalex-snapshot
Regulation of Phosphodiesterase 3 and Inducible cAMP Early Repressor in the Heart
inferred← citeshttps://doi.org/10.1161/01.res.0000261934.56938.38openalex-snapshot
cAMP-Specific Phosphodiesterase-4 Enzymes in the Cardiovascular System
inferred← citeshttps://doi.org/10.1161/circresaha.106.144501openalex-snapshot
cAMP and cGMP Signaling Cross-Talk
inferred← citeshttps://doi.org/10.1161/circresaha.108.187880openalex-snapshot
Dynamic Protein Kinase A Activities Induced by β-Adrenoceptors Dictate Signaling Propagation for Substrate Phosphorylation and Myocyte Contraction
inferred← citeshttps://doi.org/10.1161/circresaha.110.231340openalex-snapshot
Compartmentalization of β-Adrenergic Signals in Cardiomyocytes
inferred← citeshttps://doi.org/10.1161/circresaha.117.310520openalex-snapshot
Adrenergic Receptors in Individual Ventricular Myocytes
inferred← citeshttps://doi.org/10.1161/circulationaha.116.022281openalex-snapshot
Inhibiting Insulin-Mediated β 2 -Adrenergic Receptor Activation Prevents Diabetes-Associated Cardiac Dysfunction
inferred← citeshttps://doi.org/10.1161/jaha.123.033733openalex-snapshot
Differential Downregulation of β 1 ‐Adrenergic Receptor Signaling in the Heart
inferred← citeshttps://doi.org/10.1165/rcmb.2006-0257ocopenalex-snapshot
Pleiotropic β-Agonist–Promoted Receptor Conformations and Signals Independent of Intrinsic Activity
inferred← citeshttps://doi.org/10.1172/jci44747openalex-snapshot
Phosphodiesterase 4B in the cardiac L-type Ca2+ channel complex regulates Ca2+ current and protects against ventricular arrhythmias in mice
inferred← citeshttps://doi.org/10.1183/16000617.0206-2022openalex-snapshot
Phosphodiesterase 4B inhibition: a potential novel strategy for treating pulmonary fibrosis
inferred← citeshttps://doi.org/10.1186/1478-811x-11-64openalex-snapshot
GRK2 blockade with βARKct is essential for cardiac β2-adrenergic receptor signaling towards increased contractility
inferred← citeshttps://doi.org/10.1186/s12964-019-0346-2openalex-snapshot
Estrogen regulation of cardiac cAMP-L-type Ca2+ channel pathway modulates sex differences in basal contraction and responses to β2AR-mediated stress in left ventricular apical myocytes
inferred← citeshttps://doi.org/10.1186/s12964-022-00947-8openalex-snapshot
Probing spatiotemporal PKA activity at the ryanodine receptor and SERCA2a nanodomains in cardomyocytes
inferred← citeshttps://doi.org/10.1201/9781420020847.ch20openalex-snapshot
Role of Phosphodiesterases in Cyclic Nucleotide Compartmentation in Cardiac Myocytes
inferred← citeshttps://doi.org/10.1201/9781420020847.seccopenalex-snapshot
Insights into the Physiological Functions of PDE4 from Knockout Mice
inferred← citeshttps://doi.org/10.1213/ane.0b013e3181ee8312openalex-snapshot
β2-Adrenergic Receptor-Coupled Phosphoinositide 3-Kinase Constrains cAMP-Dependent Increases in Cardiac Inotropy Through Phosphodiesterase 4 Activation
inferred← citeshttps://doi.org/10.1242/jcs.140251openalex-snapshot
PDE4B mediates local feedback regulation of β1-adrenergic cAMP signaling in a sarcolemmal compartment of cardiac myocytes
inferred← citeshttps://doi.org/10.1253/circj.cj-13-0749openalex-snapshot
Differential Effect of Phosphodiesterase-3 Inhibitors on Sympathetic Hyperinnervation in Healed Rat Infarcts
inferred← citeshttps://doi.org/10.12659/msm.881763openalex-snapshot
Identification of cytosolic phosphodiesterases in the erythrocyte: A possible role for PDE5
inferred← citeshttps://doi.org/10.1371/journal.pone.0007399openalex-snapshot
Effect of DLK1 and RTL1 but Not MEG3 or MEG8 on Muscle Gene Expression in Callipyge Lambs
inferred← citeshttps://doi.org/10.1371/journal.pone.0032244openalex-snapshot
A Biphasic and Brain-Region Selective Down-Regulation of Cyclic Adenosine Monophosphate Concentrations Supports Object Recognition in the Rat
inferred← citeshttps://doi.org/10.1371/journal.pone.0042658openalex-snapshot
Palmitoylation Regulates Intracellular Trafficking of β2 Adrenergic Receptor/Arrestin/Phosphodiesterase 4D Complexes in Cardiomyocytes
inferred← citeshttps://doi.org/10.1517/14728222.10.5.677openalex-snapshot
Phosphodiesterase 4D and heart failure: a cautionary tale
inferred← citeshttps://doi.org/10.1517/14728222.9.6.1283openalex-snapshot
Phosphodiesterase-4 as a potential drug target
inferred← citeshttps://doi.org/10.2174/157488408785747719openalex-snapshot
Therapeutic Implications of Beta-Adrenergic Receptor Pharmacodynamic Properties
inferred← citeshttps://doi.org/10.3390/cells14060460openalex-snapshot
Role of PDE4 Family in Cardiomyocyte Physiology and Heart Failure
inferred← citeshttps://doi.org/10.3390/hearts2010014openalex-snapshot
Molecular Basis of Atrial Fibrillation Initiation and Maintenance
inferred← citeshttps://doi.org/10.3390/ijms141224726openalex-snapshot
βArrestins in Cardiac G Protein-Coupled Receptor Signaling and Function: Partners in Crime or “Good Cop, Bad Cop”?
inferred← citeshttps://doi.org/10.3390/ijms21165704openalex-snapshot
Dominant-Negative Attenuation of cAMP-Selective Phosphodiesterase PDE4D Action Affects Learning and Behavior
inferred← citeshttps://doi.org/10.3390/ijms22052593openalex-snapshot
Phosphodiesterases Expression during Murine Cardiac Development
inferred← citeshttps://doi.org/10.3797/scipharm.1404-08openalex-snapshot
Selective Phosphodiesterase 4B Inhibitors: A Review
inferred← citeshttps://doi.org/10.5301/ijao.2011.8510openalex-snapshot
Video Evaluation of the Kinematics and Dynamics of the Beating Cardiac Syncytium: An Alternative to the Langendorff Method
inferred← citeshttps://doi.org/10.6084/m9.figshare.21117542openalex-snapshot
Additional file 2 of Probing spatiotemporal PKA activity at the ryanodine receptor and SERCA2a nanodomains in cardomyocytes
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