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A class of iron chelators with a wide spectrum of potent antitumor activity that overcomes resistance to chemotherapeutics

https://doi.org/10.1073/pnas.0604979103
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/ijc.11223openalex-snapshot
Iron chelation, angiogenesis and tumor therapy
inferredcites →https://doi.org/10.1006/phrs.2000.0769openalex-snapshot
The preventive role of deferoxamine against acute doxorubicin-induced cardiac, renal and hepatic toxicity in rats
inferredcites →https://doi.org/10.1007/bf01534700openalex-snapshot
Isolation and genetic characterization of human KB cell lines resistant to multiple drugs
inferredcites →https://doi.org/10.1007/s00775-003-0486-zopenalex-snapshot
Cytotoxic iron chelators: characterization of the structure, solution chemistry and redox activity of ligands and iron complexes of the di-2-pyridyl ketone isonicotinoyl hydrazone (HPKIH) analogues
inferredcites →https://doi.org/10.1007/s007750050312openalex-snapshot
Crystal and molecular structure of 2-hydroxy-1-naphthaldehyde isonicotinoyl hydrazone (NIH) and its iron(III) complex: an iron chelator with anti-tumour activity
inferredcites →https://doi.org/10.1016/0014-5793(79)80111-8openalex-snapshot
Mobilization of iron from reticulocytes
inferredcites →https://doi.org/10.1016/j.critrevonc.2004.12.010openalex-snapshot
Immunosuppressors and reversion of multidrug-resistance
inferredcites →https://doi.org/10.1016/j.ejca.2004.01.023openalex-snapshot
Combination of a CpG-oligodeoxynucleotide and a topoisomerase I inhibitor in the therapy of human tumour xenografts
inferredcites →https://doi.org/10.1016/s0006-2952(99)00419-0openalex-snapshot
Triapine (3-aminopyridine-2-carboxaldehyde- thiosemicarbazone): A potent inhibitor of ribonucleotide reductase activity with broad spectrum antitumor activity
inferredcites →https://doi.org/10.1016/s0021-9258(19)57466-xopenalex-snapshot
Multiple drug-resistant human KB carcinoma cells independently selected for high-level resistance to colchicine, adriamycin, or vinblastine show changes in expression of specific proteins.
inferredcites →https://doi.org/10.1016/s0300-9084(01)01356-6openalex-snapshot
TP53: a key gene in human cancer
inferredcites →https://doi.org/10.1016/s0304-419x(02)00068-9openalex-snapshot
The role of iron in cell cycle progression and the proliferation of neoplastic cells
inferredcites →https://doi.org/10.1021/jm0606342openalex-snapshot
Dipyridyl Thiosemicarbazone Chelators with Potent and Selective Antitumor Activity Form Iron Complexes with Redox Activity
inferredcites →https://doi.org/10.1038/sj.bjp.0705089openalex-snapshot
Identification of the di‐pyridyl ketone isonicotinoyl hydrazone (PKIH) analogues as potent iron chelators and anti‐tumour agents
inferredcites →https://doi.org/10.1073/pnas.0510573103openalex-snapshot
A multifunctional cytoprotective agent that reduces neurodegeneration after ischemia
inferredcites →https://doi.org/10.1074/jbc.m001914200openalex-snapshot
Reactive Oxygen Species Generated at Mitochondrial Complex III Stabilize Hypoxia-inducible Factor-1α during Hypoxia
inferredcites →https://doi.org/10.1093/carcin/22.10.1607openalex-snapshot
p53-independent apoptosis mediated by tachpyridine, an anti-cancer iron chelator
inferredcites →https://doi.org/10.1093/carcin/bgl045openalex-snapshot
The function of melanotransferrin: a role in melanoma cell proliferation and tumorigenesis
inferredcites →https://doi.org/10.1097/00001622-199511000-00013openalex-snapshot
Cancer therapy and p53
inferredcites →https://doi.org/10.1124/mol.105.013383openalex-snapshot
Molecular Pharmacology of the Interaction of Anthracyclines with Iron
inferredcites →https://doi.org/10.1124/pr.57.4.2openalex-snapshot
The Evolution of Iron Chelators for the Treatment of Iron Overload Disease and Cancer
inferredcites →https://doi.org/10.1146/annurev.bi.48.070179.001025openalex-snapshot
Reduction of Ribonucleotides
inferredcites →https://doi.org/10.1158/0008-5472.can-05-0641openalex-snapshot
Gefitinib Reverses Chemotherapy Resistance in Gefitinib-Insensitive Multidrug Resistant Cancer Cells Expressing ATP-Binding Cassette Family Protein
inferredcites →https://doi.org/10.1158/1078-0432.ccr-04-0865openalex-snapshot
Potent Antitumor Activity of Novel Iron Chelators Derived from Di-2-Pyridylketone Isonicotinoyl Hydrazone Involves Fenton-Derived Free Radical Generation
inferredcites →https://doi.org/10.1182/blood-2004-03-0868openalex-snapshot
Novel di-2-pyridyl–derived iron chelators with marked and selective antitumor activity: in vitro and in vivo assessment
inferredcites →https://doi.org/10.1182/blood-2004-05-1866openalex-snapshot
Iron chelators with high antiproliferative activity up-regulate the expression of a growth inhibitory and metastasis suppressor gene: a link between iron metabolism and proliferation
inferredcites →https://doi.org/10.1182/blood.v86.11.4295.bloodjournal86114295openalex-snapshot
The potential of iron chelators of the pyridoxal isonicotinoyl hydrazone class as effective antiproliferative agents
inferredcites →https://doi.org/10.1182/blood.v89.8.3025openalex-snapshot
The Potential of Iron Chelators of the Pyridoxal Isonicotinoyl Hydrazone Class as Effective Antiproliferative Agents II: The Mechanism of Action of Ligands Derived From Salicylaldehyde Benzoyl Hydrazone and 2-Hydroxy-1-Naphthylaldehyde Benzoyl Hydrazone
inferredcites →https://doi.org/10.1182/blood.v98.3.842openalex-snapshot
The potential of iron chelators of the pyridoxal isonicotinoyl hydrazone class as effective antiproliferative agents, IV: the mechanisms involved in inhibiting cell-cycle progression
inferredcites →https://doi.org/10.1385/ct:3:2:89openalex-snapshot
Dexrazoxane (ICRF-187) Protects Cardiac Myocytes Against Doxorubicin by Preventing Damage to Mitochondria
inferredcites →https://doi.org/10.2174/092986705774462996openalex-snapshot
Molecular Mechanisms of Iron Uptake by Cells and the Use of Iron Chelators for the Treatment of Cancer
inferredcites →https://doi.org/10.2174/1568026043387269openalex-snapshot
Iron Chelators in Cancer Chemotherapy

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Coordination Versatility of Metal Complexes: Spectral Characterization, Crystal Structures, Biological Activity and in Silico Docking Studies
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Metallodrugs in Medicine
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Tumor Targeted Delivery of an Anti‐Cancer Therapeutic: An In Vitro and In Vivo Evaluation
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An Iron Balance Dual‐Drive Strategy (IBDS) Promotes Bone Regeneration in Smokers by Regulating Mitochondrial Iron Homeostasis
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Engineering Alendronate‐Composed Iron Nanochelator for Efficient Peritoneal Carcinomatosis Treatment
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Iron chelation beyond transfusion iron overload
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Antitumor activity and mechanism of action of the iron chelator, Dp44mT, against leukemic cells
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Potent ribonucleotide reductase inhibitors: Thiazole‐containing thiosemicarbazone derivatives
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Simultaneous determination of the novel thiosemicarbazone anti‐cancer agent, Bp4eT, and its main phase I metabolites in plasma: Application to a pilot pharmacokinetic study in rats
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A sensitive liquid chromatography–mass spectrometry bioanalytical assay for a novel anticancer candidate – ZMC1
inferred← citeshttps://doi.org/10.1002/cam4.2982openalex-snapshot
Iron protects childhood acute lymphoblastic leukemia cells from methotrexate cytotoxicity
inferred← citeshttps://doi.org/10.1002/cbdv.202500202openalex-snapshot
Pyridine Thiosemicarbazones as Anticancer and Antimicrobial Agents: A Promising Class of Low‐Toxicity Therapeutics
inferred← citeshttps://doi.org/10.1002/cplu.201200141openalex-snapshot
Synthesis, Physicochemical Studies, Molecular Dynamics Simulations, and Metal‐Ion‐Dependent Antiproliferative and Antiangiogenic Properties of Cone ICL670‐Substituted Calix[4]arenes
inferred← citeshttps://doi.org/10.1002/emmm.201100190openalex-snapshot
N‐myc downstream regulated gene 1 modulates Wnt‐β‐catenin signalling and pleiotropically suppresses metastasis
inferred← citeshttps://doi.org/10.1002/hep.23541openalex-snapshot
Hemochromatosis gene (HFE) mutations and cancer risk
inferred← citeshttps://doi.org/10.1002/ijc.25255openalex-snapshot
The antitumor activity of the fungicide ciclopirox
inferred← citeshttps://doi.org/10.1002/jcph.113openalex-snapshot
Iron Chelation in the Treatment of Cancer: A New Role for Deferasirox?
inferred← citeshttps://doi.org/10.1002/jhet.3144openalex-snapshot
Diversification of 6‐bromo‐2‐substituted Pyridine Derivatives via Suzuki‐Miyaura Cross‐Coupling
inferred← citeshttps://doi.org/10.1002/open.202500333openalex-snapshot
Evolution of Thiosemicarbazones: From First‐ to Second‐Generation Metal Chelators and Their Reactive Oxygen Species‐Mediated Effects in Melanoma
inferred← citeshttps://doi.org/10.1002/path.5104openalex-snapshot
The iron chelator deferasirox synergises with chemotherapy to treat triple‐negative breast cancers
inferred← citeshttps://doi.org/10.1002/pbc.25183openalex-snapshot
Clinical phenotype and genetic analysis of RPS19, RPL5, and RPL11 genes in Greek patients with Diamond Blackfan Anemia
inferred← citeshttps://doi.org/10.1007/978-1-60327-485-2_24openalex-snapshot
Iron Metabolism in Cancer and Infection
inferred← citeshttps://doi.org/10.1007/978-3-540-47648-1_1053openalex-snapshot
Chelators as Anti-Cancer Drugs
inferred← citeshttps://doi.org/10.1007/978-3-642-16483-5_1053openalex-snapshot
Chelators as Anti-Cancer Drugs
inferred← citeshttps://doi.org/10.1007/978-3-642-27841-9_1053-3openalex-snapshot
Chelators as Anti-Cancer Drugs
inferred← citeshttps://doi.org/10.1007/978-3-662-46875-3_1053openalex-snapshot
Chelators as Anti-Cancer Drugs
inferred← citeshttps://doi.org/10.1007/978-981-16-1247-3_210-1openalex-snapshot
Recent Advances in the Development of Synthetic Pro-oxidants: Implications for ROS based Cancer Therapeutics
inferred← citeshttps://doi.org/10.1007/978-981-16-5422-0_210openalex-snapshot
Recent Advances in the Development of Synthetic Pro-oxidants: Implications for ROS-Based Cancer Therapeutics
inferred← citeshttps://doi.org/10.1007/978-981-16-8341-1_10openalex-snapshot
Micellar Potentiometric Determination of Stability Constant and Antibacterial Investigations on Complexes of Cu (II) with 3, 4, 5-Trimethoxybenzaldehyde Thiosemicarbazone
inferred← citeshttps://doi.org/10.1007/s00011-017-1067-xopenalex-snapshot
Di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT), an anticancer agent, exerts an anti-inflammatory effect in activated human mast cells
inferred← citeshttps://doi.org/10.1007/s00018-011-0887-zopenalex-snapshot
SNX3-dependent regulation of epidermal growth factor receptor (EGFR) trafficking and degradation by aspirin in epidermoid carcinoma (A-431) cells
inferred← citeshttps://doi.org/10.1007/s00044-020-02503-wopenalex-snapshot
Synthesis and anticancer activities of thiosemicarbazones derivatives of thiochromanones and related scaffolds
inferred← citeshttps://doi.org/10.1007/s00216-009-3448-7openalex-snapshot
Development of an LC–MS/MS method for analysis of interconvertible Z/E isomers of the novel anticancer agent, Bp4eT
inferred← citeshttps://doi.org/10.1007/s00216-012-5766-4openalex-snapshot
LC-MS/MS identification of the principal in vitro and in vivo phase I metabolites of the novel thiosemicarbazone anti-cancer drug, Bp4eT
inferred← citeshttps://doi.org/10.1007/s00216-012-6562-xopenalex-snapshot
Identification of in vitro metabolites of the novel anti-tumor thiosemicarbazone, DpC, using ultra-high performance liquid chromatography–quadrupole-time-of-flight mass spectrometry
inferred← citeshttps://doi.org/10.1007/s00280-011-1587-yopenalex-snapshot
The iron chelator Dp44mT inhibits the proliferation of cancer cells but fails to protect from doxorubicin-induced cardiotoxicity in spontaneously hypertensive rats
inferred← citeshttps://doi.org/10.1007/s00775-013-1070-9openalex-snapshot
Kinetic studies on the oxidation of oxyhemoglobin by biologically active iron thiosemicarbazone complexes: relevance to iron-chelator-induced methemoglobinemia
inferred← citeshttps://doi.org/10.1007/s00775-016-1350-2openalex-snapshot
Increased generation of intracellular reactive oxygen species initiates selective cytotoxicity against the MCF-7 cell line resultant from redox active combination therapy using copper–thiosemicarbazone complexes
inferred← citeshttps://doi.org/10.1007/s00775-016-1390-7openalex-snapshot
Cytotoxic activity of expanded coordination bis-thiosemicarbazones and copper complexes thereof
inferred← citeshttps://doi.org/10.1007/s00775-019-01728-4openalex-snapshot
Novel pyridinecarboxaldehyde thiosemicarbazone conjugated magnetite nanoparticulates (MNPs) promote apoptosis in human lung cancer A549 cells
inferred← citeshttps://doi.org/10.1007/s00775-023-02037-7openalex-snapshot
Desulfurization of thiosemicarbazones: the role of metal ions and biological implications
inferred← citeshttps://doi.org/10.1007/s10311-019-00887-9openalex-snapshot
Advances in the antimicrobial and therapeutic potential of siderophores
inferred← citeshttps://doi.org/10.1007/s10534-012-9586-yopenalex-snapshot
Human apo-lactoferrin as a physiological mimetic of hypoxia stabilizes hypoxia-inducible factor-1 alpha
inferred← citeshttps://doi.org/10.1007/s10534-016-9945-1openalex-snapshot
Investigation of the cytotoxic implications of metal chelators against melanoma and approaches to improve the cytotoxicity profiles of metal coordinating agents
inferred← citeshttps://doi.org/10.1007/s10534-017-0037-7openalex-snapshot
Iron metabolism and drug resistance in cancer
inferred← citeshttps://doi.org/10.1007/s10534-020-00243-3openalex-snapshot
Iron chelators in cancer therapy
inferred← citeshttps://doi.org/10.1007/s10534-025-00736-zopenalex-snapshot
ABCC1 promotes GSH-dependent iron transport and resistance to Fe(II) and Cu(II) chelators
inferred← citeshttps://doi.org/10.1007/s10555-023-10135-wopenalex-snapshot
Metastasis suppressor genes in clinical practice: are they druggable?
inferred← citeshttps://doi.org/10.1007/s10637-018-0703-9openalex-snapshot
A phase I study of the safety and tolerability of VLX600, an Iron Chelator, in patients with refractory advanced solid tumors
inferred← citeshttps://doi.org/10.1007/s10870-023-01001-2openalex-snapshot
Metal Complexes of a Thiosemicarbazone with Heterocyclic Bases as Coligands: Spectral Characterization, Crystal Structures, DFT and In silico Docking Studies
inferred← citeshttps://doi.org/10.1007/s10973-013-3065-8openalex-snapshot
Molecular modeling, spectral, and biological studies of 4-formylpyridine-4 N-(2-pyridyl) thiosemicarbazone (HFPTS) and its Mn(II), Fe(III), Co(II), Ni(II), Cu(II), Cd(II), Hg(II), and UO2(II) complexes
inferred← citeshttps://doi.org/10.1007/s11224-019-01371-4openalex-snapshot
Water-induced isomerism of salicylaldehyde and 2-acetylpyridine mono- and bis-(thiocarbohydrazones) improves the antioxidant activity: spectroscopic and DFT study
inferred← citeshttps://doi.org/10.1007/s12094-011-0621-1openalex-snapshot
The role of iron in tumour cell proliferation
inferred← citeshttps://doi.org/10.1007/s13277-016-4878-4openalex-snapshot
Iron chelator-induced apoptosis via the ER stress pathway in gastric cancer cells
inferred← citeshttps://doi.org/10.1007/s13738-016-0934-7openalex-snapshot
2-Imino 2H-chromene and 2-(phenylimino) 2H-chromene 3-aryl carboxamide derivatives as novel cytotoxic agents: synthesis, biological assay, and molecular docking study
inferred← citeshttps://doi.org/10.1016/b978-0-444-53717-1.01720-0openalex-snapshot
Triapine®
inferred← citeshttps://doi.org/10.1016/b978-0-444-62635-6.00023-1openalex-snapshot
Metal antagonists
inferred← citeshttps://doi.org/10.1016/j.arabjc.2015.05.015openalex-snapshot
Synthesis, characterization and cytotoxic investigations of novel bis(indole) analogues besides antimicrobial study
inferred← citeshttps://doi.org/10.1016/j.arabjc.2017.11.017openalex-snapshot
Selenotriapine – An isostere of the most studied thiosemicarbazone with pronounced pro-apoptotic activity, low toxicity and ability to challenge phenotype reprogramming of 3-D mammary adenocarcinoma tumors
inferred← citeshttps://doi.org/10.1016/j.bbadis.2018.04.011openalex-snapshot
Identification of differential phosphorylation and sub-cellular localization of the metastasis suppressor, NDRG1
inferred← citeshttps://doi.org/10.1016/j.bbadis.2019.02.008openalex-snapshot
Two mechanisms involving the autophagic and proteasomal pathways process the metastasis suppressor protein, N-myc downstream regulated gene 1
inferred← citeshttps://doi.org/10.1016/j.bbadis.2019.165657openalex-snapshot
Regulation of autophagy and apoptosis by Dp44mT-mediated activation of AMPK in pancreatic cancer cells
inferred← citeshttps://doi.org/10.1016/j.bbadis.2020.165844openalex-snapshot
Acireductone dioxygenase 1 (ADI1) is regulated by cellular iron by a mechanism involving the iron chaperone, PCBP1, with PCBP2 acting as a potential co-chaperone
inferred← citeshttps://doi.org/10.1016/j.bbadis.2020.165970openalex-snapshot
The anti-tumor agent, Dp44mT, promotes nuclear translocation of TFEB via inhibition of the AMPK-mTORC1 axis
inferred← citeshttps://doi.org/10.1016/j.bbagen.2008.04.003openalex-snapshot
Cancer cell iron metabolism and the development of potent iron chelators as anti-tumour agents
inferred← citeshttps://doi.org/10.1016/j.bbagen.2017.10.009openalex-snapshot
Transcriptional regulation of the cyclin-dependent kinase inhibitor, p21 CIP1/WAF1 , by the chelator, Dp44mT
inferred← citeshttps://doi.org/10.1016/j.bbagen.2019.06.010openalex-snapshot
Iron homeostasis and iron-regulated ROS in cell death, senescence and human diseases
inferred← citeshttps://doi.org/10.1016/j.bbagen.2020.129625openalex-snapshot
NDRG1 suppresses basal and hypoxia-induced autophagy at both the initiation and degradation stages and sensitizes pancreatic cancer cells to lysosomal membrane permeabilization
inferred← citeshttps://doi.org/10.1016/j.bbagen.2020.129650openalex-snapshot
The c-MET oncoprotein: Function, mechanisms of degradation and its targeting by novel anti-cancer agents
inferred← citeshttps://doi.org/10.1016/j.bbagen.2021.130078openalex-snapshot
Ascorbate-and iron-driven redox activity of Dp44mT and Emodin facilitates peroxidation of micelles and bicelles
inferred← citeshttps://doi.org/10.1016/j.bbagen.2022.130152openalex-snapshot
The thiosemicarbazone, DpC, broadly synergizes with multiple anti-cancer therapeutics and demonstrates temperature- and energy-dependent uptake by tumor cells
inferred← citeshttps://doi.org/10.1016/j.bbamcr.2008.05.016openalex-snapshot
The iron-regulated metastasis suppressor, Ndrg-1: Identification of novel molecular targets
inferred← citeshttps://doi.org/10.1016/j.bbamcr.2015.08.010openalex-snapshot
Roles of NGAL and MMP-9 in the tumor microenvironment and sensitivity to targeted therapy
inferred← citeshttps://doi.org/10.1016/j.bbamcr.2016.01.025openalex-snapshot
Roads to melanoma: Key pathways and emerging players in melanoma progression and oncogenic signaling
inferred← citeshttps://doi.org/10.1016/j.bbamcr.2016.01.026openalex-snapshot
Redox cycling metals: Pedaling their roles in metabolism and their use in the development of novel therapeutics
inferred← citeshttps://doi.org/10.1016/j.bbamcr.2016.04.017openalex-snapshot
Lysosomal membrane stability plays a major role in the cytotoxic activity of the anti-proliferative agent, di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT)
inferred← citeshttps://doi.org/10.1016/j.bbamcr.2016.09.011openalex-snapshot
The Anticancer Agent, Di-2-Pyridylketone 4,4-Dimethyl-3-Thiosemicarbazone (Dp44mT), Up-Regulates the AMPK-Dependent Energy Homeostasis Pathway in Cancer Cells
inferred← citeshttps://doi.org/10.1016/j.bbapap.2013.08.009openalex-snapshot
Proteomics identified nuclear N-myc downstream-regulated gene 1 as a prognostic tissue biomarker candidate in renal cell carcinoma
inferred← citeshttps://doi.org/10.1016/j.bbcan.2008.07.002openalex-snapshot
Drug development against metastasis-related genes and their pathways: A rationale for cancer therapy
inferred← citeshttps://doi.org/10.1016/j.bbcan.2010.07.005openalex-snapshot
The translational regulator eIF3a: The tricky eIF3 subunit!
inferred← citeshttps://doi.org/10.1016/j.bbcan.2013.11.002openalex-snapshot
Molecular functions of the iron-regulated metastasis suppressor, NDRG1, and its potential as a molecular target for cancer therapy
inferred← citeshttps://doi.org/10.1016/j.bbcan.2014.01.005openalex-snapshot
Expanding horizons in iron chelation and the treatment of cancer: Role of iron in the regulation of ER stress and the epithelial–mesenchymal transition
inferred← citeshttps://doi.org/10.1016/j.bbcan.2023.188871openalex-snapshot
The role of the NDRG1 in the pathogenesis and treatment of breast cancer
inferred← citeshttps://doi.org/10.1016/j.bbrc.2010.08.100openalex-snapshot
The role of iron in the proliferation of Drosophila l(2)mbn cells
inferred← citeshttps://doi.org/10.1016/j.bbrc.2018.10.054openalex-snapshot
RETRACTED: Iron chelator-induced up-regulation of Ndrg1 inhibits proliferation and EMT process by targeting Wnt/β-catenin pathway in colon cancer cells
inferred← citeshttps://doi.org/10.1016/j.bcmd.2007.02.003openalex-snapshot
Transferrin receptor 2 is frequently expressed in human cancer cell lines
inferred← citeshttps://doi.org/10.1016/j.bcp.2012.03.021openalex-snapshot
The anticancer thiosemicarbazones Dp44mT and triapine lack inhibitory effects as catalytic inhibitors or poisons of DNA topoisomerase IIα
inferred← citeshttps://doi.org/10.1016/j.bcp.2014.08.006openalex-snapshot
Distinct mechanisms of cell-kill by triapine and its terminally dimethylated derivative Dp44mT due to a loss or gain of activity of their copper(II) complexes
inferred← citeshttps://doi.org/10.1016/j.bcp.2016.04.001openalex-snapshot
Mechanism of the induction of endoplasmic reticulum stress by the anti-cancer agent, di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT): Activation of PERK/eIF2α, IRE1α, ATF6 and calmodulin kinase
inferred← citeshttps://doi.org/10.1016/j.biocel.2024.106610openalex-snapshot
Novel meroterpene-like compounds inhibit ferroptosis through Fe2+ chelation
inferred← citeshttps://doi.org/10.1016/j.biomaterials.2008.09.057openalex-snapshot
In vitro chelating, cytotoxicity, and blood compatibility of degradable poly(ethylene glycol)-based macromolecular iron chelators
inferred← citeshttps://doi.org/10.1016/j.biomaterials.2010.06.012openalex-snapshot
Amphiphilic hyper-branched co-polymer nanoparticles for the controlled delivery of anti-tumor agents
inferred← citeshttps://doi.org/10.1016/j.biomaterials.2022.121760openalex-snapshot
Biomimetic Dp44mT-nanoparticles selectively induce apoptosis in Cu-loaded glioblastoma resulting in potent growth inhibition
inferred← citeshttps://doi.org/10.1016/j.biopha.2022.113736openalex-snapshot
Azulene hydrazide-hydrazones for selective targeting of pancreatic cancer cells
inferred← citeshttps://doi.org/10.1016/j.bmc.2008.04.071openalex-snapshot
Aroyl hydrazones of 2-phenylindole-3-carbaldehydes as novel antimitotic agents
inferred← citeshttps://doi.org/10.1016/j.bmc.2009.11.057openalex-snapshot
Synthesis and biological properties of iron chelators based on a bis-2-(2-hydroxy-phenyl)-thiazole-4-carboxamide or -thiocarboxamide (BHPTC) scaffold
inferred← citeshttps://doi.org/10.1016/j.bmc.2010.02.025openalex-snapshot
Investigating the anti-proliferative activity of styrylazanaphthalenes and azanaphthalenediones
inferred← citeshttps://doi.org/10.1016/j.bmc.2015.05.006openalex-snapshot
Selective induction of oxidative stress in cancer cells via synergistic combinations of agents targeting redox homeostasis
inferred← citeshttps://doi.org/10.1016/j.bmcl.2011.09.068openalex-snapshot
Molecular design, synthesis and bioactivity of glycosyl hydrazine and hydrazone derivatives: Notable effects of the sugar moiety
inferred← citeshttps://doi.org/10.1016/j.bmcl.2012.07.030openalex-snapshot
Synthesis and characterization of quinoline-based thiosemicarbazones and correlation of cellular iron-binding efficacy to anti-tumor efficacy
inferred← citeshttps://doi.org/10.1016/j.bmcl.2012.07.090openalex-snapshot
Synthesis and biological evaluation of optically active conjugated γ- and δ-lactone derivatives
inferred← citeshttps://doi.org/10.1016/j.bmcl.2012.12.044openalex-snapshot
Synthesis and biological evaluation of substituted 2-benzoylpyridine thiosemicarbazones: Novel structure–activity relationships underpinning their anti-proliferative and chelation efficacy
inferred← citeshttps://doi.org/10.1016/j.bmcl.2017.10.074openalex-snapshot
NOTA analogue: A first dithiocarbamate inhibitor of metallo-β-lactamases
inferred← citeshttps://doi.org/10.1016/j.bmcl.2025.130405openalex-snapshot
The Pyrimidinyl Hydrazones: Selective for anti-Cancer cytotoxicity
inferred← citeshttps://doi.org/10.1016/j.canlet.2010.07.010openalex-snapshot
Anti-tumor and radiosensitization activities of the iron chelator HDp44mT are mediated by effects on intracellular redox status
inferred← citeshttps://doi.org/10.1016/j.canlet.2014.01.029openalex-snapshot
Iron homeostasis in breast cancer
inferred← citeshttps://doi.org/10.1016/j.canlet.2016.08.006openalex-snapshot
EGFR regulates iron homeostasis to promote cancer growth through redistribution of transferrin receptor 1
inferred← citeshttps://doi.org/10.1016/j.cbi.2024.111092openalex-snapshot
The role of cyclin-dependent kinase inhibitor 3 in the proliferation and migration of renal cell carcinoma
inferred← citeshttps://doi.org/10.1016/j.cbpa.2012.12.021openalex-snapshot
Clawing back: broadening the notion of metal chelators in medicine
inferred← citeshttps://doi.org/10.1016/j.ccr.2020.213666openalex-snapshot
Hydrazone based spin crossover complexes: Behind the extra flexibility of the hydrazone moiety to switch the spin state
inferred← citeshttps://doi.org/10.1016/j.ccr.2021.214104openalex-snapshot
Advancement of metal compounds as therapeutic and diagnostic metallodrugs: Current frontiers and future perspectives
inferred← citeshttps://doi.org/10.1016/j.cej.2026.174136openalex-snapshot
A tumor-targeting coordination nanomedicine dual-disrupts the macrophage-iron metabolism axis against leptomeningeal carcinomatosis
inferred← citeshttps://doi.org/10.1016/j.cellsig.2025.111961openalex-snapshot
VIRMA utilizes m6A-IGF2BP2 to mediate NDRG1, thereby increasing sensitivity to iron-chelating agents and subsequently inhibiting the proliferation and metastasis of oral squamous cell carcinoma
inferred← citeshttps://doi.org/10.1016/j.celrep.2012.07.003openalex-snapshot
Luminal Iron Levels Govern Intestinal Tumorigenesis after Apc Loss In Vivo
inferred← citeshttps://doi.org/10.1016/j.celrep.2014.02.042openalex-snapshot
Iron Metabolism Regulates p53 Signaling through Direct Heme-p53 Interaction and Modulation of p53 Localization, Stability, and Function
inferred← citeshttps://doi.org/10.1016/j.cmet.2012.04.021openalex-snapshot
Iron Homeostasis Regulates the Activity of the MicroRNA Pathway through Poly(C)-Binding Protein 2
inferred← citeshttps://doi.org/10.1016/j.colsurfb.2019.110481openalex-snapshot
Development and in vitro assessment of an anti-tumor nano-formulation
inferred← citeshttps://doi.org/10.1016/j.critrevonc.2013.10.008openalex-snapshot
Epidemiological and nonclinical studies investigating effects of iron in carcinogenesis—A critical review
inferred← citeshttps://doi.org/10.1016/j.critrevonc.2015.05.012openalex-snapshot
The role of ABC transporters in ovarian cancer progression and chemoresistance
inferred← citeshttps://doi.org/10.1016/j.critrevonc.2018.11.011openalex-snapshot
Red blood cell transfusion and its alternatives in oncologic surgery—A critical evaluation
inferred← citeshttps://doi.org/10.1016/j.critrevonc.2022.103772openalex-snapshot
Puzzling out iron complications in cancer drug resistance
inferred← citeshttps://doi.org/10.1016/j.dld.2010.07.006openalex-snapshot
Beyond hereditary hemochromatosis: New insights into the relationship between iron overload and chronic liver diseases
inferred← citeshttps://doi.org/10.1016/j.drup.2012.03.002openalex-snapshot
Collateral sensitivity as a strategy against cancer multidrug resistance
inferred← citeshttps://doi.org/10.1016/j.ejmech.2010.09.007openalex-snapshot
New class of potent antitumor acylhydrazone derivatives containing furan
inferred← citeshttps://doi.org/10.1016/j.ejmech.2014.07.044openalex-snapshot
A review on anticancer potential of bioactive heterocycle quinoline
inferred← citeshttps://doi.org/10.1016/j.ejmech.2016.03.078openalex-snapshot
Design, synthesis and biological evaluation of thiosemicarbazones, hydrazinobenzothiazoles and arylhydrazones as anticancer agents with a potential to overcome multidrug resistance
inferred← citeshttps://doi.org/10.1016/j.ejmech.2016.05.015openalex-snapshot
Aroylhydrazone iron chelators: Tuning antioxidant and antiproliferative properties by hydrazide modifications
inferred← citeshttps://doi.org/10.1016/j.ejmech.2017.08.021openalex-snapshot
A novel class of thiosemicarbazones show multi-functional activity for the treatment of Alzheimer's disease
inferred← citeshttps://doi.org/10.1016/j.ejmech.2018.02.009openalex-snapshot
Gold(III) bis(thiosemicarbazonate) compounds in breast cancer cells: Cytotoxicity and thioredoxin reductase targeting
inferred← citeshttps://doi.org/10.1016/j.ejmech.2018.06.042openalex-snapshot
Synthesis and antiplasmodial activity of glyco-conjugate hybrids of phenylhydrazono-indolinones and glycosylated 1,2,3-triazolyl-methyl-indoline-2,3-diones
inferred← citeshttps://doi.org/10.1016/j.ejmech.2019.01.014openalex-snapshot
Mitochondria-localizing N-heterocyclic thiosemicarbazone copper complexes with good cytotoxicity and high antimetastatic activity
inferred← citeshttps://doi.org/10.1016/j.ejmech.2019.03.027openalex-snapshot
Anticancer activity of the thiosemicarbazones that are based on di-2-pyridine ketone and quinoline moiety
inferred← citeshttps://doi.org/10.1016/j.ejmech.2022.114415openalex-snapshot
Mechanism of vitamin B6 benzoyl hydrazone platinum(II) complexes overcomes multidrug resistance in lung cancer
inferred← citeshttps://doi.org/10.1016/j.exphem.2013.02.004openalex-snapshot
Deferasirox shows in vitro and in vivo antileukemic effects on murine leukemic cell lines regardless of iron status
inferred← citeshttps://doi.org/10.1016/j.freeradbiomed.2007.08.008openalex-snapshot
Peroxide hormesis? A commentary on “Hydrogen peroxide inhibits caspase-dependent apoptosis by inactivating procaspase-9 in an iron-dependent manner”
inferred← citeshttps://doi.org/10.1016/j.freeradbiomed.2013.02.016openalex-snapshot
Redox activation of Fe(III)–thiosemicarbazones and Fe(III)–bleomycin by thioredoxin reductase: specificity of enzymatic redox centers and analysis of reactive species formation by ESR spin trapping
inferred← citeshttps://doi.org/10.1016/j.freeradbiomed.2015.12.008openalex-snapshot
Enhanced targeting of mitochondrial peroxide defense by the combined use of thiosemicarbazones and inhibitors of thioredoxin reductase
inferred← citeshttps://doi.org/10.1016/j.freeradbiomed.2016.04.201openalex-snapshot
Turning the gun on cancer: Utilizing lysosomal P-glycoprotein as a new strategy to overcome multi-drug resistance
inferred← citeshttps://doi.org/10.1016/j.freeradbiomed.2018.03.027openalex-snapshot
Ironing out the role of the cyclin-dependent kinase inhibitor, p21 in cancer: Novel iron chelating agents to target p21 expression and activity
inferred← citeshttps://doi.org/10.1016/j.freeradbiomed.2018.12.013openalex-snapshot
Suppressive effects of iron chelation in clear cell renal cell carcinoma and their dependency on VHL inactivation
inferred← citeshttps://doi.org/10.1016/j.freeradbiomed.2019.05.020openalex-snapshot
Pharmacological targeting and the diverse functions of the metastasis suppressor, NDRG1, in cancer
inferred← citeshttps://doi.org/10.1016/j.htct.2025.106233openalex-snapshot
Mechanistic insights into the antiproliferative effect of the redox-active iron chelator Dp44mT on multiple myeloma cell lines
inferred← citeshttps://doi.org/10.1016/j.ica.2010.04.018openalex-snapshot
Transition metal complexes of 2-formylpyridinethiosemicarbazone (HFpyTSC) and X-ray crystal structures of [Pd(FpyTSC)(PPh3)]PF6 and [Pd(FpyTSC)(SCN)]
inferred← citeshttps://doi.org/10.1016/j.ica.2017.11.013openalex-snapshot
Evaluation of DNA binding and DNA cleavage of nickel(II) complexes with tridentate α-N-heterocyclic thiosemicarbazones ligands
inferred← citeshttps://doi.org/10.1016/j.ica.2025.123004openalex-snapshot
Advancing anticancer chelation therapy: Insights from enhancing cytotoxic potency, targeted cellular delivery, metal-based immunomodulation, and combinatorial strategies
inferred← citeshttps://doi.org/10.1016/j.inoche.2026.116401openalex-snapshot
Nickel(II) dithiocarbazate-derived complexes: Synthesis, characterization, biomolecular interactions, and mechanistic anticancer activity
inferred← citeshttps://doi.org/10.1016/j.isci.2019.10.065openalex-snapshot
E6AP Promotes a Metastatic Phenotype in Prostate Cancer
inferred← citeshttps://doi.org/10.1016/j.jbc.2021.101414openalex-snapshot
The metastasis suppressor NDRG1 directly regulates androgen receptor signaling in prostate cancer
inferred← citeshttps://doi.org/10.1016/j.jbc.2022.101608openalex-snapshot
Targeting Wnt/tenascin C-mediated cross talk between pancreatic cancer cells and stellate cells via activation of the metastasis suppressor NDRG1
inferred← citeshttps://doi.org/10.1016/j.jbc.2024.107417openalex-snapshot
Multi-modal mechanisms of the metastasis suppressor, NDRG1: Inhibition of WNT/β-catenin signaling by stabilization of protein kinase Cα
inferred← citeshttps://doi.org/10.1016/j.jchromb.2008.11.044openalex-snapshot
HPLC methods for determination of two novel thiosemicarbazone anti-cancer drugs (N4mT and Dp44mT) in plasma and their application to in vitro plasma stability of these agents
inferred← citeshttps://doi.org/10.1016/j.jconrel.2024.08.024openalex-snapshot
An “Iron-phagy” nanoparticle inducing irreversible mitochondrial damages for antitumor therapy
inferred← citeshttps://doi.org/10.1016/j.jinorgbio.2007.10.013openalex-snapshot
Electron paramagnetic resonance study of peripheral blood mononuclear cells from patients with refractory solid tumors treated with Triapine®
inferred← citeshttps://doi.org/10.1016/j.jinorgbio.2010.07.012openalex-snapshot
The iron complex of Dp44mT is redox-active and induces hydroxyl radical formation: An EPR study
inferred← citeshttps://doi.org/10.1016/j.jinorgbio.2013.09.016openalex-snapshot
Complex forming competition and in-vitro toxicity studies on the applicability of di-2-pyridylketone-4,4,-dimethyl-3-thiosemicarbazone (Dp44mT) as a metal chelator
inferred← citeshttps://doi.org/10.1016/j.jinorgbio.2014.07.020openalex-snapshot
Synthesis and biological evaluation of 2-benzoylpyridine thiosemicarbazones in a dimeric system: Structure–activity relationship studies on their anti-proliferative and iron chelation efficacy
inferred← citeshttps://doi.org/10.1016/j.jinorgbio.2014.12.015openalex-snapshot
Synthesis and characterization of the anticancer and metal binding properties of novel pyrimidinylhydrazone derivatives
inferred← citeshttps://doi.org/10.1016/j.jinorgbio.2015.08.010openalex-snapshot
Identification of differential anti-neoplastic activity of copper bis(thiosemicarbazones) that is mediated by intracellular reactive oxygen species generation and lysosomal membrane permeabilization
inferred← citeshttps://doi.org/10.1016/j.jinorgbio.2015.08.023openalex-snapshot
Vanadium(IV/V) complexes of Triapine and related thiosemicarbazones: Synthesis, solution equilibrium and bioactivity
inferred← citeshttps://doi.org/10.1016/j.jinorgbio.2015.10.006openalex-snapshot
Differences in protein binding and excretion of Triapine and its Fe(III) complex
inferred← citeshttps://doi.org/10.1016/j.jinorgbio.2016.04.006openalex-snapshot
Synthesis, characterization and biological activities of semicarbazones and their copper complexes
inferred← citeshttps://doi.org/10.1016/j.jinorgbio.2018.10.006openalex-snapshot
Synthesis and biological evaluation of biotin-conjugated anticancer thiosemicarbazones and their iron(III) and copper(II) complexes
inferred← citeshttps://doi.org/10.1016/j.jpba.2006.11.011openalex-snapshot
Development and validation of HPLC-DAD methods for the analysis of two novel iron chelators with potent anti-cancer activity
inferred← citeshttps://doi.org/10.1016/j.jpcs.2021.110368openalex-snapshot
A 1D silver(I) coordination polymer of a new hydrozone-hydrazide ligand: Spectral, structural, emission, and anti-bacterial properties and its application as a solid source precursor for silver oxide nanoparticles
inferred← citeshttps://doi.org/10.1016/j.jtemb.2018.01.011openalex-snapshot
Metal transport capabilities of anticancer copper chelators
inferred← citeshttps://doi.org/10.1016/j.leukres.2014.06.005openalex-snapshot
Iron chelators induce autophagic cell death in multiple myeloma cells
inferred← citeshttps://doi.org/10.1016/j.lfs.2021.119146openalex-snapshot
Biochemical effects of deferasirox and deferasirox-loaded nanomicellesin iron-intoxicated rats
inferred← citeshttps://doi.org/10.1016/j.mehy.2022.110907openalex-snapshot
Attenuation of tryptophan metabolism by Fe chelators: A hypothesis regarding inhibiting tumor suppressive microenvironments in pancreatic ductal adenocarcinoma
inferred← citeshttps://doi.org/10.1016/j.molliq.2020.114605openalex-snapshot
Deferasirox-loaded pluronic nanomicelles: Synthesis, characterization, in vitro and in vivo studies
inferred← citeshttps://doi.org/10.1016/j.molstruc.2012.11.050openalex-snapshot
Microwave assisted synthesis, X-ray crystallography and DFT calculations of selected aromatic thiosemicarbazones
inferred← citeshttps://doi.org/10.1016/j.molstruc.2019.04.126openalex-snapshot
HSA-interaction studies of uranyl complexes of alkyl substituted isothiosemicarbazone
inferred← citeshttps://doi.org/10.1016/j.molstruc.2021.130722openalex-snapshot
Synthesis and cytotoxicity screening of some synthesized hybrid nitrogen molecules as anticancer agents
inferred← citeshttps://doi.org/10.1016/j.msec.2018.12.080openalex-snapshot
Crystal structures, spectroscopic properties of new cobalt(II), nickel(II), zinc(II) and palladium(II) complexes derived from 2-acetyl-5-chloro thiophene thiosemicarbazone: Anticancer evaluation
inferred← citeshttps://doi.org/10.1016/j.msec.2018.12.138openalex-snapshot
Sugar-conjugated dendritic mesoporous silica nanoparticles as pH-responsive nanocarriers for tumor targeting and controlled release of deferasirox
inferred← citeshttps://doi.org/10.1016/j.pharmr.2025.100087openalex-snapshot
Metal-based antibody, nanobody, and peptide conjugates: Potential for breast cancer therapy
inferred← citeshttps://doi.org/10.1016/j.pharmr.2025.100102openalex-snapshot
Leading artificial intelligence–driven drug discovery platforms: 2025 landscape and global outlook
inferred← citeshttps://doi.org/10.1016/j.phrs.2015.08.013openalex-snapshot
The renaissance of polypharmacology in the development of anti-cancer therapeutics: Inhibition of the “Triad of Death” in cancer by Di-2-pyridylketone thiosemicarbazones
inferred← citeshttps://doi.org/10.1016/j.phrs.2016.12.001openalex-snapshot
Metals and metastasis: Exploiting the role of metals in cancer metastasis to develop novel anti-metastatic agents
inferred← citeshttps://doi.org/10.1016/j.phrs.2021.105889openalex-snapshot
Innovative therapies for neuroblastoma: The surprisingly potent role of iron chelation in up-regulating metastasis and tumor suppressors and down-regulating the key oncogene, N-myc
inferred← citeshttps://doi.org/10.1016/j.phrs.2023.106806openalex-snapshot
Innovative thiosemicarbazones that induce multi-modal mechanisms to down-regulate estrogen-, progesterone-, androgen- and prolactin-receptors in breast cancer
inferred← citeshttps://doi.org/10.1016/j.phrs.2025.107967openalex-snapshot
Thiosemicarbazones down-regulate N-Myc expression in neuroblastoma cells via transcriptional and post-translational mechanisms
inferred← citeshttps://doi.org/10.1016/j.poly.2011.02.048openalex-snapshot
Self-assembling dicopper(II) complexes of di-2-pyridyl ketone Schiff base ligands derived from S-alkyldithiocarbazates
inferred← citeshttps://doi.org/10.1016/j.redox.2020.101611openalex-snapshot
Iron regulates myeloma cell/macrophage interaction and drives resistance to bortezomib
inferred← citeshttps://doi.org/10.1016/j.redox.2020.101661openalex-snapshot
Defective mitochondrial ISCs biogenesis switches on IRP1 to fine tune selective mitophagy
inferred← citeshttps://doi.org/10.1016/j.redox.2021.101896openalex-snapshot
Parkinson's disease: Alterations in iron and redox biology as a key to unlock therapeutic strategies
inferred← citeshttps://doi.org/10.1016/j.stem.2021.12.009openalex-snapshot
The microbiota regulates hematopoietic stem cell fate decisions by controlling iron availability in bone marrow
inferred← citeshttps://doi.org/10.1016/j.tet.2011.01.008openalex-snapshot
Synthesis of gemini triethylene-tetramine bridged bis-tridentate iron(III) chelators
inferred← citeshttps://doi.org/10.1016/j.tet.2012.06.021openalex-snapshot
Synthesis and evaluation of fluorimetric and colorimetric chemosensors for anions based on (oligo)thienyl-thiosemicarbazones
inferred← citeshttps://doi.org/10.1016/j.tet.2024.134122openalex-snapshot
Exploring triazole-based drugs: Synthesis, application, FDA approvals, and clinical trial updates–A comprehensive review
inferred← citeshttps://doi.org/10.1016/j.tetlet.2013.05.105openalex-snapshot
Facile synthesis of ninhydrin and isatin based hydrazones in water using PEG-OSO3H as a highly efficient and homogeneous polymeric acid-surfactant combined catalyst
inferred← citeshttps://doi.org/10.1016/j.tips.2009.07.003openalex-snapshot
Is resistance useless? Multidrug resistance and collateral sensitivity
inferred← citeshttps://doi.org/10.1016/j.toxlet.2010.12.017openalex-snapshot
The iron-chelating drug triapine causes pronounced mitochondrial thiol redox stress
inferred← citeshttps://doi.org/10.1016/j.yexcr.2017.03.048openalex-snapshot
Reduced cancer mortality at high altitude: The role of glucose, lipids, iron and physical activity
inferred← citeshttps://doi.org/10.1016/s0378-6080(09)03123-7openalex-snapshot
Metal antagonists
inferred← citeshttps://doi.org/10.1021/acs.bioconjchem.6b00332openalex-snapshot
Targeting Iron in Colon Cancer via Glycoconjugation of Thiosemicarbazone Prochelators
inferred← citeshttps://doi.org/10.1021/acs.inorgchem.3c01738openalex-snapshot
Design and Synthesis of Poly(2,2′-Bipyridyl) Ligands for Induction of Cell Death in Cancer Cells: Control of Anticancer Activity by Complexation/Decomplexation with Biorelevant Metal Cations
inferred← citeshttps://doi.org/10.1021/acs.inorgchem.4c03642openalex-snapshot
Innovative N-Acridine Thiosemicarbazones and Their Zn(II) Complexes Transmetallate with Cu(II): Redox Activity and Suppression of Detrimental Oxy-Myoglobin Oxidation
inferred← citeshttps://doi.org/10.1021/acs.inorgchem.5c04463openalex-snapshot
Biological and Catalytic Potential of Vanadium Complexes of N -Methyl- N -phenylhydrazinecarbothioamide Based ONS Donor Ligands
inferred← citeshttps://doi.org/10.1021/acs.inorgchem.9b01281openalex-snapshot
Synthesis, Characterization, and in Vitro Anticancer Activity of Copper and Zinc Bis(Thiosemicarbazone) Complexes
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