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Structural insights into the Slit-Robo complex

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1 of the 39 references listed on this page is in the Retraction Watch database as retracted (export 2026-10-21): 10.1126/science.1058445 (notice 2023-08-31).

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1006/geno.2002.6745openalex-snapshot

Magic Roundabout Is a New Member of the Roundabout Receptor Family That Is Endothelial Specific and Expressed at Sites of Active Angiogenesis

inferredcites →https://doi.org/10.1006/mcne.1998.0672openalex-snapshot

TheDUTT1Gene, a Novel NCAM Family Member Is Expressed in Developing Murine Neural Tissues and Has an Unusually Broad Pattern of Expression

inferredcites →https://doi.org/10.1007/s001090000082openalex-snapshot

Ligand-binding sites in Ig-like domains of receptor tyrosine kinases

inferredcites →https://doi.org/10.1016/0022-2836(92)90891-mopenalex-snapshot

Modularity of the slit protein

inferredcites →https://doi.org/10.1016/j.cub.2005.10.037openalex-snapshot

Slit and Robo Control Cardiac Cell Polarity and Morphogenesis

inferredcites →https://doi.org/10.1016/j.mcn.2004.01.002openalex-snapshot

Extracellular Ig domains 1 and 2 of Robo are important for ligand (Slit) binding

inferredcites →https://doi.org/10.1016/j.mcn.2005.07.014openalex-snapshot

Evidence for the existence of two Robo3 isoforms with divergent biochemical properties

inferredcites →https://doi.org/10.1016/s0012-1606(03)00258-6openalex-snapshot

Robo4 is a vascular-specific receptor that inhibits endothelial migration

inferredcites →https://doi.org/10.1016/s0076-6879(97)76073-7openalex-snapshot

[27] Maximum-likelihood heavy-atom parameter refinement for multiple isomorphous replacement and multiwavelength anomalous diffraction methods

inferredcites →https://doi.org/10.1016/s0092-8674(00)80588-7openalex-snapshot

Biochemical Purification of a Mammalian Slit Protein as a Positive Regulator of Sensory Axon Elongation and Branching

inferredcites →https://doi.org/10.1016/s0092-8674(00)80590-5openalex-snapshot

Slit Proteins Bind Robo Receptors and Have an Evolutionarily Conserved Role in Repulsive Axon Guidance

inferredcites →https://doi.org/10.1016/s0092-8674(00)80591-7openalex-snapshot

Vertebrate Slit, a Secreted Ligand for the Transmembrane Protein Roundabout, Is a Repellent for Olfactory Bulb Axons

inferredcites →https://doi.org/10.1016/s0092-8674(00)80852-1openalex-snapshot

The Crystal Structure of the Ligand Binding Module of Axonin-1/TAG-1 Suggests a Zipper Mechanism for Neural Cell Adhesion

inferredcites →https://doi.org/10.1016/s0092-8674(00)80915-0openalex-snapshot

Roundabout Controls Axon Crossing of the CNS Midline and Defines a Novel Subfamily of Evolutionarily Conserved Guidance Receptors

inferredcites →https://doi.org/10.1016/s0092-8674(04)00303-4openalex-snapshot

The Divergent Robo Family Protein Rig-1/Robo3 Is a Negative Regulator of Slit Responsiveness Required for Midline Crossing by Commissural Axons

inferredcites →https://doi.org/10.1016/s0169-328x(98)00224-1openalex-snapshot

Cloning and expressions of three mammalian homologues of Drosophila slit suggest possible roles for Slit in the formation and maintenance of the nervous system

inferredcites →https://doi.org/10.1016/s0896-6273(03)00232-0openalex-snapshot

Structure of the Nogo Receptor Ectodomain

inferredcites →https://doi.org/10.1016/s1097-2765(00)00073-3openalex-snapshot

Crystal Structure of a Ternary FGF-FGFR-Heparin Complex Reveals a Dual Role for Heparin in FGFR Binding and Dimerization

inferredcites →https://doi.org/10.1038/35039551openalex-snapshot

Crystal structure of fibroblast growth factor receptor ectodomain bound to ligand and heparin

inferredcites →https://doi.org/10.1038/43705openalex-snapshot

Crystal structure of nerve growth factor in complex with the ligand-binding domain of the TrkA receptor

inferredcites →https://doi.org/10.1038/nature03875openalex-snapshot

Common mechanisms of nerve and blood vessel wiring

inferredcites →https://doi.org/10.1038/sj.emboj.7600446openalex-snapshot

Binding site for Robo receptors revealed by dissection of the leucine‐rich repeat region of Slit

inferredcites →https://doi.org/10.1073/pnas.0605284103openalex-snapshot

Lateral positioning at the dorsal midline: Slit and Roundabout receptors guide Drosophila heart cell migration

inferredcites →https://doi.org/10.1073/pnas.95.8.4134openalex-snapshot

A dimeric crystal structure for the N-terminal two domains of intercellular adhesion molecule-1

inferredcites →https://doi.org/10.1074/jbc.m308083200openalex-snapshot

Slit Protein-mediated Inhibition of CXCR4-induced Chemotactic and Chemoinvasive Signaling Pathways in Breast Cancer Cells

inferredcites →https://doi.org/10.1074/jbc.m609384200openalex-snapshot

A Molecular Mechanism for the Heparan Sulfate Dependence of Slit-Robo Signaling

inferredcites →https://doi.org/10.1080/10409230490906797openalex-snapshot

Axon Guidance at the Midline: From Mutants to Mechanisms

inferredcites →https://doi.org/10.1093/nar/30.2.e9openalex-snapshot

High-level and high-throughput recombinant protein production by transient transfection of suspension-growing human 293-EBNA1 cells

inferredcites →https://doi.org/10.1107/s0021889893005588openalex-snapshot

Automatic processing of rotation diffraction data from crystals of initially unknown symmetry and cell constants

inferredcites →https://doi.org/10.1107/s0907444902011678openalex-snapshot

Substructure solution withSHELXD

inferredcites →https://doi.org/10.1107/s0907444907035470openalex-snapshot

Production of Slit2 LRR domains in mammalian cells for structural studies and the structure of human Slit2 domain 3

inferredcites →https://doi.org/10.1107/s0907444994003112openalex-snapshot

The CCP4 suite: programs for protein crystallography

inferredcites →https://doi.org/10.1107/s1744309107033027openalex-snapshot

Cloning, expression, crystallization and preliminary X-ray analysis of the first two Ig domains from human Roundabout 1 (Robo1)

inferredcites →https://doi.org/10.1126/science.1058445openalex-snapshot

RETRACTED: Hierarchical Organization of Guidance Receptors: Silencing of Netrin Attraction by Slit Through a Robo/DCC Receptor Complex

inferredcites →https://doi.org/10.1126/science.107355openalex-snapshot

Structures of Glycoprotein Ibα and Its Complex with von Willebrand Factor A1 Domain

inferredcites →https://doi.org/10.1146/annurev.cellbio.21.090704.151234openalex-snapshot

Regulation of Commissural Axon Pathfinding by Slit and its Robo Receptors

inferredcites →https://doi.org/10.1158/1078-0432.ccr-05-2787openalex-snapshot

Identification of ROBO1 as a Novel Hepatocellular Carcinoma Antigen and a Potential Therapeutic and Diagnostic Target

inferredcites →https://doi.org/10.1191/1358863x06vm658raopenalex-snapshot

Potential role of the Slit/Robo signal pathway in angiogenesis

inferredcites →https://doi.org/10.1523/jneurosci.21-12-04281.2001openalex-snapshot

Diversity and Specificity of Actions of Slit2 Proteolytic Fragments in Axon Guidance

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.4115314openalex-extracted

inferred← citeshttps://doi.org/10.1002/0471266949.bmc271openalex-snapshot

Angiogenesis Inhibitors

inferred← citeshttps://doi.org/10.1002/1878-0261.13289openalex-snapshot

Slit2/Robo1 signaling inhibits small‐cell lung cancer by targeting β‐catenin signaling in tumor cells and macrophages

inferred← citeshttps://doi.org/10.1002/cncr.25890openalex-snapshot

A novel exon 15‐deleted, splicing variant of Slit2 shows potential for growth inhibition in addition to invasion inhibition in lung cancer

inferred← citeshttps://doi.org/10.1002/cph4.70210openalex-snapshot

SLIT – ROBO Signaling in Diabetes: A Dual Regulator of Angiogenesis and Vascular Dysfunction

inferred← citeshttps://doi.org/10.1002/dvdy.512openalex-snapshot

Structure and evolution of neuronal wiring receptors and ligands

inferred← citeshttps://doi.org/10.1002/dvg.23443openalex-snapshot

The Slit‐binding Ig1 domain is required for multiple axon guidance activities of Drosophila Robo2

inferred← citeshttps://doi.org/10.1002/hep.32164openalex-snapshot

Genomic evolution and the impact of SLIT2 mutation in relapsed intrahepatic cholangiocarcinoma

inferred← citeshttps://doi.org/10.1002/jmr.928openalex-snapshot

Survey of the year 2007 commercial optical biosensor literature

inferred← citeshttps://doi.org/10.1002/jnr.23364openalex-snapshot

Robo3.1A suppresses Slit-mediated repulsion by triggering degradation of Robo2

inferred← citeshttps://doi.org/10.1002/ntls.20220021openalex-snapshot

Diverse roles for axon guidance pathways in adult tissue architecture and function

inferred← citeshttps://doi.org/10.1002/pro.2619openalex-snapshot

Structural features of interfacial tyrosine residue in ROBO1 fibronectin domain‐antibody complex: Crystallographic, thermodynamic, and molecular dynamic analyses

inferred← citeshttps://doi.org/10.1002/prot.21937openalex-snapshot

Comparative structural analysis of the binding domain of follicle stimulating hormone receptor

inferred← citeshttps://doi.org/10.1002/prot.22440openalex-snapshot

Quantitative analysis and prediction of curvature in leucine‐rich repeat proteins

inferred← citeshttps://doi.org/10.1007/5584_2020_586openalex-snapshot

Roles of Slit Ligands and Their Roundabout (Robo) Family of Receptors in Bone Remodeling

inferred← citeshttps://doi.org/10.1007/978-1-4614-8090-7_7openalex-snapshot

ROUNDABOUT Receptors

inferred← citeshttps://doi.org/10.1007/978-3-030-28151-9_9openalex-snapshot

Structure and Function of Roundabout Receptors

inferred← citeshttps://doi.org/10.1007/978-3-031-81991-9_16openalex-snapshot

Axon Guidance Receptor Endocytosis, Trafficking, and Signaling in Health and Disease

inferred← citeshttps://doi.org/10.1007/s00018-013-1431-0openalex-snapshot

Domain structure and function of matrix metalloprotease 23 (MMP23): role in potassium channel trafficking

inferred← citeshttps://doi.org/10.1007/s00418-011-0806-2openalex-snapshot

Expression and roles of Slit/Robo in human ovarian cancer

inferred← citeshttps://doi.org/10.1007/s00467-009-1179-9openalex-snapshot

Mutations in the ROBO2 and SLIT2 genes are rare causes of familial vesico-ureteral reflux

inferred← citeshttps://doi.org/10.1007/s10456-008-9100-xopenalex-snapshot

Slits and Roundabouts in cancer, tumour angiogenesis and endothelial cell migration

inferred← citeshttps://doi.org/10.1007/s10456-015-9467-4openalex-snapshot

The differential roles of Slit2-exon 15 splicing variants in angiogenesis and HUVEC permeability

inferred← citeshttps://doi.org/10.1007/s11684-015-0416-9openalex-snapshot

Function of Slit/Robo signaling in breast cancer

inferred← citeshttps://doi.org/10.1007/s13361-018-1903-4openalex-snapshot

A Traveling Wave Ion Mobility Spectrometry (TWIMS) Study of the Robo1-Heparan Sulfate Interaction

inferred← citeshttps://doi.org/10.1016/b978-0-12-386503-8.00005-3openalex-snapshot

A Roundabout Way to Cancer

inferred← citeshttps://doi.org/10.1016/b978-0-12-397266-8.00146-0openalex-snapshot

Axon Guidance

inferred← citeshttps://doi.org/10.1016/b978-0-12-801238-3.99546-1openalex-snapshot

OBSOLETE: Vascular Guidance Cues

inferred← citeshttps://doi.org/10.1016/b978-0-12-809657-4.99546-2openalex-snapshot

Vascular Guidance Cues

inferred← citeshttps://doi.org/10.1016/b978-0-443-13825-6.00143-6openalex-snapshot

Angiogenesis

inferred← citeshttps://doi.org/10.1016/j.ajog.2009.07.040openalex-snapshot

Increased SLIT immunoreactivity as a biomarker for recurrence in endometrial carcinoma

inferred← citeshttps://doi.org/10.1016/j.bbrc.2015.12.075openalex-snapshot

Suppression of Slit2/Robo1 mediated HUVEC migration by Robo4

inferred← citeshttps://doi.org/10.1016/j.bbrc.2023.04.030openalex-snapshot

Upregulation of ROBO3 promotes proliferation, migration and adhesion of AML cells and affects the survival of AML patients

inferred← citeshttps://doi.org/10.1016/j.bihy.2009.07.001openalex-snapshot

A possible role of receptors in the SLIT/ROBO and NETRIN/DCC pathways in the genesis of multiple sclerosis

inferred← citeshttps://doi.org/10.1016/j.bmcl.2026.130656openalex-snapshot

Computational design and biophysical validation of macrocyclic peptides as inhibitors of SLIT2/ROBO1 interaction

inferred← citeshttps://doi.org/10.1016/j.cell.2019.02.004openalex-snapshot

Structural Principles in Robo Activation and Auto-inhibition

inferred← citeshttps://doi.org/10.1016/j.cels.2026.101645openalex-snapshot

High-throughput machine learning-aided antibody discovery for cell surface antigens

inferred← citeshttps://doi.org/10.1016/j.cytogfr.2014.11.007openalex-snapshot

Angiogenic growth factors interactome and drug discovery: The contribution of surface plasmon resonance

inferred← citeshttps://doi.org/10.1016/j.devcel.2010.12.001openalex-snapshot

Robo4 Maintains Vessel Integrity and Inhibits Angiogenesis by Interacting with UNC5B

inferred← citeshttps://doi.org/10.1016/j.devcel.2014.12.021openalex-snapshot

Robo3: The Road Taken

inferred← citeshttps://doi.org/10.1016/j.devcel.2018.10.028openalex-snapshot

Adhesive L1CAM-Robo Signaling Aligns Growth Cone F-Actin Dynamics to Promote Axon-Dendrite Fasciculation in C. elegans

inferred← citeshttps://doi.org/10.1016/j.fertnstert.2010.09.027openalex-snapshot

Increased immunoreactivity to SLIT/ROBO1 and its correlation with severity of dysmenorrhea in adenomyosis

inferred← citeshttps://doi.org/10.1016/j.gene.2015.11.035openalex-snapshot

BmRobo2/3 is required for axon guidance in the silkworm Bombyx mori

inferred← citeshttps://doi.org/10.1016/j.gene.2015.11.044openalex-snapshot

BmRobo1a and BmRobo1b control axon repulsion in the silkworm Bombyx mori

inferred← citeshttps://doi.org/10.1016/j.jmb.2011.03.013openalex-snapshot

The Immunoglobulin-like Domains 1 and 2 of the Protein Tyrosine Phosphatase LAR Adopt an Unusual Horseshoe-like Conformation

inferred← citeshttps://doi.org/10.1016/j.jmb.2011.10.030openalex-snapshot

Crystal Structure of the Ligand Binding Domain of Netrin G2

inferred← citeshttps://doi.org/10.1016/j.jmb.2015.03.001openalex-snapshot

LRIG1 Extracellular Domain: Structure and Function Analysis

inferred← citeshttps://doi.org/10.1016/j.jmb.2017.10.002openalex-snapshot

Robo Ig4 Is a Dimerization Domain

inferred← citeshttps://doi.org/10.1016/j.jmb.2022.167777openalex-snapshot

Conformational Change of the Hairpin-Like-Structured Robo2 Ectodomain Allows Nell1/2 Binding

inferred← citeshttps://doi.org/10.1016/j.jsb.2014.02.019openalex-snapshot

Crystal structure of the extracellular juxtamembrane region of Robo1

inferred← citeshttps://doi.org/10.1016/j.kint.2022.01.028openalex-snapshot

Biallelic pathogenic variants in roundabout guidance receptor 1 associate with syndromic congenital anomalies of the kidney and urinary tract

inferred← citeshttps://doi.org/10.1016/j.neuron.2013.06.035openalex-snapshot

The EBAX-type Cullin-RING E3 Ligase and Hsp90 Guard the Protein Quality of the SAX-3/Robo Receptor in Developing Neurons

inferred← citeshttps://doi.org/10.1016/j.neuron.2014.11.004openalex-snapshot

Signaling Switch of the Axon Guidance Receptor Robo3 during Vertebrate Evolution

inferred← citeshttps://doi.org/10.1016/j.oooo.2014.09.029openalex-snapshot

Frequent inactivation of SLIT2 and ROBO1 signaling in head and neck lesions: clinical and prognostic implications

inferred← citeshttps://doi.org/10.1016/j.pep.2008.05.006openalex-snapshot

Ligand-independent assembly of purified soluble magic roundabout (Robo4), a tumor-specific endothelial marker

inferred← citeshttps://doi.org/10.1016/j.sbi.2008.05.008openalex-snapshot

Ligand binding by repeat proteins: natural and designed

inferred← citeshttps://doi.org/10.1016/j.sbi.2019.11.007openalex-snapshot

Cell guidance ligands, receptors and complexes – orchestrating signalling in time and space

inferred← citeshttps://doi.org/10.1016/j.semcdb.2017.11.029openalex-snapshot

Midline axon guidance in the Drosophila embryonic central nervous system

inferred← citeshttps://doi.org/10.1016/j.str.2017.12.003openalex-snapshot

Robo1 Forms a Compact Dimer-of-Dimers Assembly

inferred← citeshttps://doi.org/10.1016/j.str.2018.01.012openalex-snapshot

Approaching the Roundabout: cis and trans Robo1 Contacts Revealed

inferred← citeshttps://doi.org/10.1016/j.str.2020.02.008openalex-snapshot

Drosophila OTK Is a Glycosaminoglycan-Binding Protein with High Conformational Flexibility

inferred← citeshttps://doi.org/10.1016/j.suronc.2016.09.003openalex-snapshot

Slit2 and Robo1 expression as biomarkers for assessing prognosis in brain glioma patients

inferred← citeshttps://doi.org/10.1016/j.ydbio.2025.01.017openalex-snapshot

Slit-independent guidance of longitudinal axons by Drosophila Robo3

inferred← citeshttps://doi.org/10.1016/j.yexcr.2011.12.005openalex-snapshot

The axonal repellent Slit2 inhibits pericyte migration: Potential implications in angiogenesis

inferred← citeshttps://doi.org/10.1021/acs.biochem.8b00241openalex-snapshot

Structural Characterization of a Heparan Sulfate Pentamer Interacting with LAR-Ig1-2

inferred← citeshttps://doi.org/10.1021/acschembio.6b00692openalex-snapshot

Structural Aspects of Heparan Sulfate Binding to Robo1–Ig1–2

inferred← citeshttps://doi.org/10.1021/acschembio.8b00511openalex-snapshot

Paramagnetic Tag for Glycosylation Sites in Glycoproteins: Structural Constraints on Heparan Sulfate Binding to Robo1

inferred← citeshttps://doi.org/10.1038/embor.2009.95openalex-snapshot

Structure and functional relevance of the Slit2 homodimerization domain

inferred← citeshttps://doi.org/10.1038/nature08995openalex-snapshot

Ephrin-B2 regulates VEGFR2 function in developmental and tumour angiogenesis

inferred← citeshttps://doi.org/10.1038/ncomms13517openalex-snapshot

The Robo4 cytoplasmic domain is dispensable for vascular permeability and neovascularization

inferred← citeshttps://doi.org/10.1038/ncomms6423openalex-snapshot

Structural basis for LAR-RPTP/Slitrk complex-mediated synaptic adhesion

inferred← citeshttps://doi.org/10.1038/nm.3849openalex-snapshot

Slit2 signaling through Robo1 and Robo2 is required for retinal neovascularization

inferred← citeshttps://doi.org/10.1038/nm1742openalex-snapshot

Robo4 stabilizes the vascular network by inhibiting pathologic angiogenesis and endothelial hyperpermeability

inferred← citeshttps://doi.org/10.1038/nn.2978openalex-snapshot

The transmembrane LRR protein DMA-1 promotes dendrite branching and growth in C. elegans

inferred← citeshttps://doi.org/10.1038/s12276-021-00633-8openalex-snapshot

Effect of Slit/Robo signaling on regeneration in lung emphysema

inferred← citeshttps://doi.org/10.1038/s41467-018-06333-8openalex-snapshot

Structural insights into modulation and selectivity of transsynaptic neurexin–LRRTM interaction

inferred← citeshttps://doi.org/10.1038/s41467-020-15211-1openalex-snapshot

NELL2-Robo3 complex structure reveals mechanisms of receptor activation for axon guidance

inferred← citeshttps://doi.org/10.1038/s41467-020-17651-1openalex-snapshot

SLIT2/ROBO1-signaling inhibits macropinocytosis by opposing cortical cytoskeletal remodeling

inferred← citeshttps://doi.org/10.1038/s41467-023-36521-0openalex-snapshot

Coadaptation fostered by the SLIT2-ROBO1 axis facilitates liver metastasis of pancreatic ductal adenocarcinoma

inferred← citeshttps://doi.org/10.1038/s41584-025-01280-3openalex-snapshot

Peripheral neuronal sensitization and neurovascular remodelling in osteoarthritis pain

inferred← citeshttps://doi.org/10.1038/s41598-020-78882-2openalex-snapshot

Structural insights and evaluation of the potential impact of missense variants on the interactions of SLIT2 with ROBO1/4 in cancer progression

inferred← citeshttps://doi.org/10.1038/s41598-021-83046-xopenalex-snapshot

The neurorepellent, Slit2, prevents macrophage lipid loading by inhibiting CD36-dependent binding and internalization of oxidized low-density lipoprotein

inferred← citeshttps://doi.org/10.1038/s41598-022-08227-8openalex-snapshot

Robo4 is constitutively shed by ADAMs from endothelial cells and the shed Robo4 functions to inhibit Slit3-induced angiogenesis

inferred← citeshttps://doi.org/10.1038/s41598-022-18769-6openalex-snapshot

NMR analysis suggests the terminal domains of Robo1 remain extended but are rigidified in the presence of heparan sulfate

inferred← citeshttps://doi.org/10.1039/9781788013291-00085openalex-snapshot

Structural and Dynamic Characterization of Protein Domains using Paramagnetic Data

inferred← citeshttps://doi.org/10.1039/c2mb05392fopenalex-snapshot

Modular recognition of nucleic acids by PUF, TALE and PPRproteins

inferred← citeshttps://doi.org/10.1039/d5md00555hopenalex-snapshot

Discovery of a first-in-class SLIT2 binder disrupting the SLIT2/ROBO1 axis via DNA-encoded library (DEL) screening

inferred← citeshttps://doi.org/10.1042/bj20140190openalex-snapshot

Roundabout 1 exists predominantly as a basal dimeric complex and this is unaffected by binding of the ligand Slit2

inferred← citeshttps://doi.org/10.1042/bsr20190513openalex-snapshot

Regulatory mechanisms of Robo4 and their effects on angiogenesis

inferred← citeshttps://doi.org/10.1042/bst0360251openalex-snapshot

Structural insight into Slit–Robo signalling

inferred← citeshttps://doi.org/10.1074/jbc.m115.648410openalex-snapshot

High Structural Resolution Hydroxyl Radical Protein Footprinting Reveals an Extended Robo1-Heparin Binding Interface

inferred← citeshttps://doi.org/10.1074/jbc.m117.804021openalex-snapshot

Identification of direct negative cross-talk between the SLIT2 and bone morphogenetic protein–Gremlin signaling pathways

inferred← citeshttps://doi.org/10.1074/jbc.m800688200openalex-snapshot

Structural and Functional Analysis of Slit and Heparin Binding to Immunoglobulin-like Domains 1 and 2 of Drosophila Robo

inferred← citeshttps://doi.org/10.1080/13543776.2026.2690118openalex-snapshot

SLIT2 and ROBO-axis inhibitors for the treatment of cancer: a patent review (2020–2026)

inferred← citeshttps://doi.org/10.1080/14728222.2020.1766445openalex-snapshot

The potential of Slit2 as a therapeutic target for central nervous system disorders

inferred← citeshttps://doi.org/10.1080/21688370.2017.1331155openalex-snapshot

The role of Slit-Robo signaling in the regulation of tissue barriers

inferred← citeshttps://doi.org/10.1093/cercor/bhr330openalex-snapshot

Robo4 Regulates the Radial Migration of Newborn Neurons in Developing Neocortex

inferred← citeshttps://doi.org/10.1093/cvr/cvv161openalex-snapshot

Slit2 modifies VEGF-induced angiogenic responses in rabbit skeletal muscle via reduced eNOS activity

inferred← citeshttps://doi.org/10.1093/cvr/cvy061openalex-snapshot

Slit–Robo signalling in heart development

inferred← citeshttps://doi.org/10.1093/genetics/iyab018openalex-snapshot

Conserved and divergent aspects of Robo receptor signaling and regulation between Drosophila Robo1 and C. elegans SAX-3

inferred← citeshttps://doi.org/10.1093/glycob/cws087openalex-snapshot

The C-terminal fragment of axon guidance molecule Slit3 binds heparin and neutralizes heparin's anticoagulant activity

inferred← citeshttps://doi.org/10.1093/jb/mvab049openalex-snapshot

Development of biparatopic bispecific antibody possessing tetravalent scFv-Fc capable of binding to ROBO1 expressed in hepatocellular carcinoma cells

inferred← citeshttps://doi.org/10.1096/fj.07-098269openalex-snapshot

Active involvement of Robo1 and Robo4 in filopodia formation and endothelial cell motility mediated via WASP and other actin nucleation‐promoting factors

inferred← citeshttps://doi.org/10.1097/nen.0000000000000146openalex-snapshot

Roundabout 4 Regulates Blood–Tumor Barrier Permeability Through the Modulation of ZO-1, Occludin, and Claudin-5 Expression

inferred← citeshttps://doi.org/10.1097/qad.0b013e32834bab86openalex-snapshot

A novel role for Slit2/Robo1 axis in modulating HIV-1 replication in T cells

inferred← citeshttps://doi.org/10.1098/rsob.180026openalex-snapshot

Roles of glycosaminoglycans as regulators of ligand/receptor complexes

inferred← citeshttps://doi.org/10.1098/rsob.250026openalex-snapshot

The Slit–Robo signalling pathway in nervous system development: a comparative perspective from vertebrates and invertebrates

inferred← citeshttps://doi.org/10.1101/2025.07.18.665327openalex-snapshot

Complexes between Netrin G Ligands and Chiral Nanoparticles Promote Axons Regeneration under Near-Infrared Illumination

inferred← citeshttps://doi.org/10.1101/cshperspect.a001875openalex-snapshot

Axon Guidance Molecules in Vascular Patterning

inferred← citeshttps://doi.org/10.1101/cshperspect.a029165openalex-snapshot

Making Connections: Guidance Cues and Receptors at Nonneural Cell–Cell Junctions

inferred← citeshttps://doi.org/10.1107/s1744309113014863openalex-snapshot

Expression, derivatization, crystallization and experimental phasing of an extracellular segment of the human Robo1 receptor

inferred← citeshttps://doi.org/10.1107/s2059798323006897openalex-snapshot

Raimond B. G. Ravelli (25 March 1968–30 June 2023)

inferred← citeshttps://doi.org/10.1111/andr.70288openalex-snapshot

Slit2/Robo Signaling Restores Diabetic Erectile Function via Neurovascular Remodeling

inferred← citeshttps://doi.org/10.1111/jse.12587openalex-snapshot

Evolution and diversity of axon guidance Robo receptor family genes

inferred← citeshttps://doi.org/10.1136/jmedgenet-2017-104611openalex-snapshot

Loss of function in ROBO1 is associated with tetralogy of Fallot and septal defects

inferred← citeshttps://doi.org/10.1146/annurev-cellbio-092910-154111openalex-snapshot

Role of Leucine-Rich Repeat Proteins in the Development and Function of Neural Circuits

inferred← citeshttps://doi.org/10.1146/annurev-cellbio-111315-125008openalex-snapshot

Structural Perspectives on Axon Guidance

inferred← citeshttps://doi.org/10.1152/ajpheart.00216.2023openalex-snapshot

SLIT3-mediated fibroblast signaling: a promising target for antifibrotic therapies

inferred← citeshttps://doi.org/10.1161/circulationaha.112.105452openalex-snapshot

The Cell Motility Modulator Slit2 Is a Potent Inhibitor of Platelet Function

inferred← citeshttps://doi.org/10.1172/jci.insight.193632openalex-snapshot

Activation of SLIT2/ROBO1/LRP6 axis aggravates cartilage degradation via β-catenin signaling in TMJOA

inferred← citeshttps://doi.org/10.1172/jci.insight.86934openalex-snapshot

SLIT2/ROBO2 signaling pathway inhibits nonmuscle myosin IIA activity and destabilizes kidney podocyte adhesion

inferred← citeshttps://doi.org/10.1177/1535370220988246openalex-snapshot

High ROBO3 expression predicts poor survival in non-M3 acute myeloid leukemia

inferred← citeshttps://doi.org/10.1177/1758835919855238openalex-snapshot

Targeting the SLIT/ROBO pathway in tumor progression: molecular mechanisms and therapeutic perspectives

inferred← citeshttps://doi.org/10.1186/1471-2121-9-61openalex-snapshot

Silencing of directional migration in roundabout4 knockdown endothelial cells

inferred← citeshttps://doi.org/10.1186/1478-811x-12-25openalex-snapshot

Slit2N and Robo4 regulate lymphangiogenesis through the VEGF-C/VEGFR-3 pathway

inferred← citeshttps://doi.org/10.1186/1742-4690-10-2openalex-snapshot

N-terminal Slit2 inhibits HIV-1 replication by regulating the actin cytoskeleton

inferred← citeshttps://doi.org/10.1186/ar2955openalex-snapshot

Slit3 inhibits Robo3-induced invasion of synovial fibroblasts in rheumatoid arthritis

inferred← citeshttps://doi.org/10.1186/s12885-015-1984-4openalex-snapshot

The emerging role of Slit-Robo pathway in gastric and other gastro intestinal cancers

inferred← citeshttps://doi.org/10.1186/s12964-020-00696-6openalex-snapshot

Slit/Robo signaling regulates Leydig cell steroidogenesis

inferred← citeshttps://doi.org/10.1186/s13023-018-0885-4openalex-snapshot

Missense mutation in SLIT2 associated with congenital myopia, anisometropia, connective tissue abnormalities, and obesity

inferred← citeshttps://doi.org/10.1186/s13064-016-0071-0openalex-snapshot

In vivo functional analysis of Drosophila Robo1 immunoglobulin-like domains

inferred← citeshttps://doi.org/10.1210/clinem/dgae320openalex-snapshot

Exome Sequencing Has a High Diagnostic Rate in Sporadic Congenital Hypopituitarism and Reveals Novel Candidate Genes

inferred← citeshttps://doi.org/10.1210/jc.2016-1095openalex-snapshot

Mutations in the Human ROBO1 Gene in Pituitary Stalk Interruption Syndrome

inferred← citeshttps://doi.org/10.1242/dev.034355openalex-snapshot

N-cadherin acts in concert with Slit1-Robo2 signaling in regulating aggregation of placode-derived cranial sensory neurons

inferred← citeshttps://doi.org/10.1242/dev.040329openalex-snapshot

LRT, a tendon-specific leucine-rich repeat protein, promotes muscle-tendon targeting through its interaction with Robo

inferred← citeshttps://doi.org/10.1242/dev.044511openalex-snapshot

Moving away from the midline: new developments for Slit and Robo

inferred← citeshttps://doi.org/10.1242/dev.065714openalex-snapshot

Sclerotome-derived Slit1 drives directional migration and differentiation of Robo2-expressing pioneer myoblasts

inferred← citeshttps://doi.org/10.1242/dev.132829openalex-snapshot

Slit-Robo signaling

inferred← citeshttps://doi.org/10.1242/dev.196055openalex-snapshot

Proteolytic cleavage of Slit by the Tolkin protease converts an axon repulsion cue to an axon growth cue in vivo

inferred← citeshttps://doi.org/10.1248/bpb.b21-00413openalex-snapshot

Vascular Leakage Prevention by Roundabout 4 under Pathological Conditions

inferred← citeshttps://doi.org/10.1371/annotation/5af1d62a-8262-4340-ad06-c450a50295e3openalex-snapshot

Correction: Slit2/Robo4 Signaling Modulates HIV-1 gp120-Induced Lymphatic Hyperpermeability

inferred← citeshttps://doi.org/10.1371/journal.pone.0021614openalex-snapshot

LRR Conservation Mapping to Predict Functional Sites within Protein Leucine-Rich Repeat Domains

inferred← citeshttps://doi.org/10.1371/journal.pone.0083461openalex-snapshot

Ligand Recognition by the TPR Domain of the Import Factor Toc64 from Arabidopsis thaliana

inferred← citeshttps://doi.org/10.1371/journal.pone.0094970openalex-snapshot

Coevolution of Axon Guidance Molecule Slit and Its Receptor Robo

inferred← citeshttps://doi.org/10.1371/journal.pone.0109377openalex-snapshot

Evolutionarily Conserved Repulsive Guidance Role of Slit in the Silkworm Bombyx mori

inferred← citeshttps://doi.org/10.1371/journal.pone.0172736openalex-snapshot

Expression patterns of Slit and Robo family members in adult mouse spinal cord and peripheral nervous system

inferred← citeshttps://doi.org/10.1371/journal.pone.0208952openalex-snapshot

Magic roundabout is an endothelial-specific ohnolog of ROBO1 which neo-functionalized to an essential new role in angiogenesis

inferred← citeshttps://doi.org/10.1371/journal.pone.0241150openalex-snapshot

Minimal structural elements required for midline repulsive signaling and regulation of Drosophila Robo1

inferred← citeshttps://doi.org/10.1371/journal.ppat.1002461openalex-snapshot

Slit2/Robo4 Signaling Modulates HIV-1 gp120-Induced Lymphatic Hyperpermeability

inferred← citeshttps://doi.org/10.14670/hh-25.1181openalex-snapshot

Perspectives of SLIT/ROBO signaling in placental angiogenesis.

inferred← citeshttps://doi.org/10.1534/g3.115.022327openalex-snapshot

Slit Binding via the Ig1 Domain Is Essential for Midline Repulsion by Drosophila Robo1 but Dispensable for Receptor Expression, Localization, and Regulation in Vivo

inferred← citeshttps://doi.org/10.1534/g3.117.300418openalex-snapshot

In Vivo Functional Analysis of Drosophila Robo1 Fibronectin Type-III Repeats

inferred← citeshttps://doi.org/10.1593/tlo.11151openalex-snapshot

Immunohistochemical Staining of Slit2 in Primary and Metastatic Prostatic Adenocarcinoma

inferred← citeshttps://doi.org/10.17582/journal.pjz/20230125150101openalex-snapshot

Recombinant Slit2 Requires Heparin Sulphate to Inhibit TGF- β Induced Tumor Proliferation in Lung Cancer and Glioblastoma

inferred← citeshttps://doi.org/10.2353/ajpath.2009.090024openalex-snapshot

Increased Immunoreactivity to SLIT/ROBO1 in Ovarian Endometriomas

inferred← citeshttps://doi.org/10.3389/fmed.2018.00335openalex-snapshot

From Vascular Smooth Muscle Cells to Folliculogenesis: What About Vasorin?

inferred← citeshttps://doi.org/10.3390/biom11020191openalex-snapshot

Lysosomal Function and Axon Guidance: Is There a Meaningful Liaison?

inferred← citeshttps://doi.org/10.3390/biom13050785openalex-snapshot

The SLIT/ROBO Pathway in Liver Fibrosis and Cancer

inferred← citeshttps://doi.org/10.3390/biom14101231openalex-snapshot

Emerging Role of the Slit/Roundabout (Robo) Signaling Pathway in Glioma Pathogenesis and Potential Therapeutic Options

inferred← citeshttps://doi.org/10.3390/cells14211654openalex-snapshot

LT1-3, a Slit2-Derived Peptide, Exhibits Anti-Tumor Activity and Improves Cisplatin Therapy

inferred← citeshttps://doi.org/10.3410/f.1103524.559589openalex-snapshot

Faculty Opinions recommendation of Robo4 stabilizes the vascular network by inhibiting pathologic angiogenesis and endothelial hyperpermeability.

inferred← citeshttps://doi.org/10.3410/f.736381523.793565762openalex-snapshot

Faculty Opinions recommendation of Temporal regulation of axonal repulsion by alternative splicing of a conserved microexon in mammalian Robo1 and Robo2.

inferred← citeshttps://doi.org/10.3892/etm.2019.7235openalex-snapshot

Antagonistic effects of exogenous Slit2 on VEGF‑induced choroidal endothelial cell migration and tube formation

inferred← citeshttps://doi.org/10.3892/ijmm.2012.1098openalex-snapshot

Fragments of SLIT3 inhibit cellular migration

inferred← citeshttps://doi.org/10.4049/jimmunol.1500640openalex-snapshot

The Neurorepellent Slit2 Inhibits Postadhesion Stabilization of Monocytes Tethered to Vascular Endothelial Cells

inferred← citeshttps://doi.org/10.4103/nrr.nrr-d-24-00564openalex-snapshot

Regulatory role of neuronal guidance proteins in spinal cord injury

inferred← citeshttps://doi.org/10.4172/jpb.1000314openalex-snapshot

Helical Parameters and Correlations of Tandem Leucine Rich Repeats in Proteins

inferred← citeshttps://doi.org/10.48550/arxiv.1405.3331openalex-snapshot

Graphic Processing Unit Simulation of Axon Growth and Guidance through Cue Diffusion on Massively Parallel Processors

inferred← citeshttps://doi.org/10.53846/goediss-9412openalex-snapshot

The role of the ROBO 3 signaling pathway in pancreatic cancer plasticity

inferred← citeshttps://doi.org/10.5772/26298openalex-snapshot

Slit/Robo Signaling: Inhibition of Directional Leukocyte Migration

inferred← citeshttps://doi.org/10.6084/m9.figshare.13626991openalex-snapshot

Additional file 2 of Slit/Robo signaling regulates Leydig cell steroidogenesis

inferred← citeshttps://doi.org/10.70675/1622b534z9107z40c2z85eez2caf8cc3454copenalex-snapshot

Guidage axonal des cellules ganglionnaires de la rétine en cours de régénération dans le noyau suprachiasmatique

inferred← citeshttps://doi.org/10.70675/48d1b8e7z25eez400fzaef9zbe8da8ab3bccopenalex-snapshot

Étude de l'histoire évolutive des gènes dans les génomes de vertébrés

inferred← citeshttps://doi.org/10.70675/9709d6aaz37b7z4de2za537zd7f1bf648566openalex-snapshot

Molecular mechanisms orchestrating commissural axon guidance

inferred← citeshttps://doi.org/10.70675/d03e67aczc44bz4af9z8fa1zef080668f44fopenalex-snapshot

Le rôle de l'érythroferrone dans la régulation du métabolisme du fer

inferred← citeshttps://doi.org/10.70675/de357a08zde04z4690z8b75z8f2bd3f595b4openalex-snapshot

Nouvelles stratégies thérapeutiques dans les carcinomes épidermoïdes des voies aéro-digestives supérieures

inferred← citeshttps://doi.org/10.7150/jca.31877openalex-snapshot

The Role of the Slit/Robo Signaling Pathway

inferred← citeshttps://doi.org/10.7554/elife.46042openalex-snapshot

Temporal regulation of axonal repulsion by alternative splicing of a conserved microexon in mammalian Robo1 and Robo2

inferred← citeshttps://doi.org/10.7554/elife.51295openalex-snapshot

Identification of slit3 as a locus affecting nicotine preference in zebrafish and human smoking behaviour

inferred← citeshttps://doi.org/10.7936/k75b00hzopenalex-snapshot

Use of Self-Assembled Monolayers to Tailor Surface Properties: From Lubrication to Neuronal Development

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