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FOXO3A genotype is strongly associated with human longevity

https://doi.org/10.1073/pnas.0801030105
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Prevalence of Dementia in Older Japanese-American Men in Hawaii
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C. elegans SIR-2.1 Interacts with 14-3-3 Proteins to Activate DAF-16 and Extend Life Span
inferredcites →https://doi.org/10.1016/j.cub.2007.08.047openalex-snapshot
An AMPK-FOXO Pathway Mediates Longevity Induced by a Novel Method of Dietary Restriction in C. elegans
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Association analysis between longevity in the Japanese population and polymorphic variants of genes involved in insulin and insulin-like growth factor 1 signaling pathways
inferredcites →https://doi.org/10.1016/j.exger.2006.06.040openalex-snapshot
The search for DAF-16/FOXO transcriptional targets: Approaches and discoveries
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New findings in gene knockout, mutant and transgenic mice☆
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FoxO proteins in insulin action and metabolism
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The Cognitive Abilities Screening Instrument (CASI): A Practical Test for Cross-Cultural Epidemiological Studies of Dementia
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Half of the Variation in Susceptibility to Mortality Is Genetic: Findings from Swedish Twin Survival Data
inferredcites →https://doi.org/10.1038/35065638openalex-snapshot
Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans
inferredcites →https://doi.org/10.1038/nature01036openalex-snapshot
Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress
inferredcites →https://doi.org/10.1038/nature01789openalex-snapshot
Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans
inferredcites →https://doi.org/10.1038/ng0406-397openalex-snapshot
Enrichment of regulatory motifs upstream of predicted DAF-16 targets
inferredcites →https://doi.org/10.1038/nrg1871openalex-snapshot
The quest for genetic determinants of human longevity: challenges and insights
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Genetic links between diet and lifespan: shared mechanisms from yeast to humans
inferredcites →https://doi.org/10.1038/nrm2190openalex-snapshot
Stressing the role of FoxO proteins in lifespan and disease
inferredcites →https://doi.org/10.1038/nrm2234openalex-snapshot
Endocrine regulation of ageing
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Inheritance of human longevity in Iceland
inferredcites →https://doi.org/10.1038/sj.ejhg.5201766openalex-snapshot
Haplotypes in the human Foxo1a and Foxo3a genes; impact on disease and mortality at old age
inferredcites →https://doi.org/10.1073/pnas.0408670102openalex-snapshot
No association between microsomal triglyceride transfer protein ( MTP ) haplotype and longevity in humans
inferredcites →https://doi.org/10.1073/pnas.0700638104openalex-snapshot
Regulation of Caenorhabditis elegans lifespan by a proteasomal E3 ligase complex
inferredcites →https://doi.org/10.1073/pnas.0705467105openalex-snapshot
Functionally significant insulin-like growth factor I receptor mutations in centenarians
inferredcites →https://doi.org/10.1073/pnas.122587599openalex-snapshot
Life-long sustained mortality advantage of siblings of centenarians
inferredcites →https://doi.org/10.1073/pnas.89.19.9112openalex-snapshot
Protein oxidation associated with aging is reduced by dietary restriction of protein or calories.
inferredcites →https://doi.org/10.1093/gerona/56.2.m79openalex-snapshot
Serum Insulin-like Growth Factor-1 in Centenarians: Implications of IGF-1 as a Rapid Turnover Protein
inferredcites →https://doi.org/10.1093/gerona/56.3.b130openalex-snapshot
Familial Excess Longevity in Utah Genealogies
inferredcites →https://doi.org/10.1093/gerona/58.3.m232openalex-snapshot
Morbidity Profiles of Centenarians: Survivors, Delayers, and Escapers
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First Autopsy Study of an Okinawan Centenarian: Absence of Many Age-Related Diseases
inferredcites →https://doi.org/10.1093/gerona/59.4.m385openalex-snapshot
Cardiovascular Disease Delay in Centenarian Offspring
inferredcites →https://doi.org/10.1093/gerona/61.4.345openalex-snapshot
Siblings of Okinawan Centenarians Share Lifelong Mortality Advantages
inferredcites →https://doi.org/10.1093/gerona/62.9.960openalex-snapshot
SIRT1 Gene, Age-Related Diseases, and Mortality: The Leiden 85-Plus Study
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inferredcites →https://doi.org/10.1097/jgp.0b013e31803190ccopenalex-snapshot
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inferredcites →https://doi.org/10.1111/j.1474-9726.2007.00290.xopenalex-snapshot
Dynamics of the action of dFOXO on adult mortality in Drosophila
inferredcites →https://doi.org/10.1111/j.1474-9726.2007.00328.xopenalex-snapshot
Loss of pregnancy‐associated plasma protein A extends lifespan in mice
inferredcites →https://doi.org/10.1111/j.1474-9726.2007.00334.xopenalex-snapshot
Some highlights of research on aging with invertebrates, 2006–2007
inferredcites →https://doi.org/10.1111/j.1474-9726.2008.00387.xopenalex-snapshot
Impact of reduced insulin‐like growth factor‐1/insulin signaling on aging in mammals: novel findings
inferredcites →https://doi.org/10.1111/j.1474-9726.2010.00649.xopenalex-snapshot
Some highlights of research on aging with invertebrates, 2010
inferredcites →https://doi.org/10.1126/science.1078223openalex-snapshot
Extended Longevity in Mice Lacking the Insulin Receptor in Adipose Tissue
inferredcites →https://doi.org/10.1126/science.1083701openalex-snapshot
Regulation of Aging and Age-Related Disease by DAF-16 and Heat-Shock Factor
inferredcites →https://doi.org/10.1126/science.1092952openalex-snapshot
Insulin Signaling in Health and Disease
inferredcites →https://doi.org/10.1126/science.1094637openalex-snapshot
Stress-Dependent Regulation of FOXO Transcription Factors by the SIRT1 Deacetylase
inferredcites →https://doi.org/10.1126/science.1115596openalex-snapshot
A Developmental Timing MicroRNA and Its Target Regulate Life Span in C. elegans
inferredcites →https://doi.org/10.1126/science.278.5341.1319openalex-snapshot
daf-16 : An HNF-3/forkhead Family Member That Can Function to Double the Life-Span of Caenorhabditis elegans
inferredcites →https://doi.org/10.1126/science.7777857openalex-snapshot
Extreme Discordant Sib Pairs for Mapping Quantitative Trait Loci in Humans
inferredcites →https://doi.org/10.1146/annurev.biochem.74.082803.133500openalex-snapshot
The Biochemistry of Sirtuins
inferredcites →https://doi.org/10.1152/physrev.1998.78.2.547openalex-snapshot
The Free Radical Theory of Aging Matures
inferredcites →https://doi.org/10.1186/1471-2350-8-s1-s13openalex-snapshot
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inferredcites →https://doi.org/10.1210/jc.2002-021810openalex-snapshot
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inferredcites →https://doi.org/10.1253/circj.66.987openalex-snapshot
New Criteria for `Obesity Disease' in Japan
inferredcites →https://doi.org/10.1253/circj.70.150openalex-snapshot
New Criteria for `Obesity Disease' in Japan
inferredcites →https://doi.org/10.1371/journal.pgen.0030056openalex-snapshot
Lifespan Regulation by Evolutionarily Conserved Genes Essential for Viability
inferredcites →https://doi.org/10.1377/hlthaff.26.5.1417openalex-snapshot
Trends In The Health Of Older Americans, 1970–2005
inferredcites →https://doi.org/10.2337/diacare.25.6.951openalex-snapshot
The American Diabetes Association and World Health Organization Classifications for Diabetes
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Type 2 Diabetes Prevalence in Asian Americans

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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FOXO in aging: Did evolutionary diversification of FOXO function distract it from prolonging life?
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Integration of diverse inputs in the regulation of Caenorhabditis elegans DAF‐16/FOXO
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Caenorhabditis elegans reproductive aging: Regulation and underlying mechanisms
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Three QTL in the honey bee Apis mellifera L. suppress reproduction of the parasitic mite Varroa destructor
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Evolution of longevity improves immunity inDrosophila
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Cellular lifespan and senescence: a complex balance between multiple cellular pathways
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Ketone bodies mimic the life span extending properties of caloric restriction
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Membrane ion Channels and Receptors in Animal lifespan Modulation
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Nampt affects mitochondrial function in aged oocytes by mediating the downstream effector FoxO3a
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Antiaging effects of bioactive molecules isolated from plants and fungi
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Vitexin and Isovitexin Act through Inhibition of Insulin Receptor to Promote Longevity and Fitness in Caenorhabditis elegans
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A kinetic assessment of the C. elegans amyloid disaggregation activity enables uncoupling of disassembly and proteolysis
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Cell and Molecular Aging
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Beating Around the “Wrong” Bush?
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Candidate Genes That Affect Aging Through Protein Homeostasis
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GWAS and Meta-Analysis in Aging/Longevity
inferred← citeshttps://doi.org/10.1007/978-1-4939-2404-2_6openalex-snapshot
Exome and Whole Genome Sequencing in Aging and Longevity
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Models to Explore Genetics of Human Aging
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What Can We Learn About Human Disease from the Nematode C. elegans?
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Detecting Polymorphisms in Human Longevity Studies: HLA Typing and SNP Genotyping by Amplicon Sequencing
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Genetic Signatures of Centenarians
inferred← citeshttps://doi.org/10.1007/978-3-030-22009-9_403openalex-snapshot
Centenarians
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Genetic Control of Aging
inferred← citeshttps://doi.org/10.1007/978-3-030-22009-9_727openalex-snapshot
Genes that Delay Aging
inferred← citeshttps://doi.org/10.1007/978-3-030-24970-0_10openalex-snapshot
Genetic Markers of Extreme Human Longevity
inferred← citeshttps://doi.org/10.1007/978-3-030-31206-0_15openalex-snapshot
Plausible Links Between Metabolic Networks, Stem Cells, and Longevity
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An Update on the Molecular Pillars of Aging
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Genomic Tools Used in Molecular Clinical Aging Research
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Diets, Nutrition, Superfoods, and Super Agers
inferred← citeshttps://doi.org/10.1007/978-3-319-14830-4_4openalex-snapshot
Hormonal Influence and Modulation in Aging
inferred← citeshttps://doi.org/10.1007/978-3-319-23246-1_7openalex-snapshot
The Role of Aging in Alzheimer’s Disease
inferred← citeshttps://doi.org/10.1007/978-3-319-44703-2_14openalex-snapshot
Lipid Metabolism, Lipid Signalling and Longevity
inferred← citeshttps://doi.org/10.1007/978-3-319-44703-2_3openalex-snapshot
Dauer Formation and Ageing
inferred← citeshttps://doi.org/10.1007/978-3-319-63001-4_5openalex-snapshot
Growth Hormone and IGF-1 Axis in Aging and Longevity
inferred← citeshttps://doi.org/10.1007/978-3-319-64543-8_10openalex-snapshot
Aging and the Biological Clock
inferred← citeshttps://doi.org/10.1007/978-3-319-69892-2_403-1openalex-snapshot
Centenarians
inferred← citeshttps://doi.org/10.1007/978-3-319-69892-2_726-1openalex-snapshot
Genetic Control of Aging
inferred← citeshttps://doi.org/10.1007/978-3-319-69892-2_727-1openalex-snapshot
Genes that Delay Aging
inferred← citeshttps://doi.org/10.1007/978-3-642-27928-7_9openalex-snapshot
Therapeutic potential of longevity modulators as neuroprotective targets in neurodegenerative disease
inferred← citeshttps://doi.org/10.1007/978-3-662-61417-4_1openalex-snapshot
Biologisches Altern
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Germline Stem Cells and Their Roles in the Regulation of Organism Longevity
inferred← citeshttps://doi.org/10.1007/978-90-481-8556-6_2openalex-snapshot
Food Intake, Life Style, Aging and Human Longevity
inferred← citeshttps://doi.org/10.1007/978-94-007-5061-6_12openalex-snapshot
Understanding the Aging Process Using Epidemiologic Approaches
inferred← citeshttps://doi.org/10.1007/978-94-007-5061-6_13openalex-snapshot
Genetics of Human Longevity and Healthy Aging
inferred← citeshttps://doi.org/10.1007/978-94-017-7587-8_20openalex-snapshot
Continuing the Search for Determinants of Healthy Life Span and Longevity
inferred← citeshttps://doi.org/10.1007/978-94-024-0962-8_10openalex-snapshot
Sirtuins and Aging
inferred← citeshttps://doi.org/10.1007/978-981-13-1117-8_1openalex-snapshot
Systems Biology in Aging Research
inferred← citeshttps://doi.org/10.1007/978-981-13-1699-9_17openalex-snapshot
Role of Phytochemicals in Eliciting Longevity Genes
inferred← citeshttps://doi.org/10.1007/978-981-13-2835-0_11openalex-snapshot
Signal Transduction Pathways in Ageing
inferred← citeshttps://doi.org/10.1007/978-981-19-4154-2_18openalex-snapshot
Effects of Interactions Between Environmental and Genetic Factors on Healthy Aging: A Review on the Relevant Prior Research
inferred← citeshttps://doi.org/10.1007/978-981-287-080-3_74-1openalex-snapshot
Okinawa Centenarian Study: Investigating Healthy Aging among the World’s Longest-Lived People
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p53 and Aging
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Molecular and Multiomics (Genomics, Proteomics, Transcriptomics) Approaches for Enhancing Anti-aging Properties of Plant Secondary Metabolites
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A novel AMPK-dependent FoxO3A-SIRT3 intramitochondrial complex sensing glucose levels
inferred← citeshttps://doi.org/10.1007/s00018-015-1985-0openalex-snapshot
Regulation of protein homeostasis in neurodegenerative diseases: the role of coding and non-coding genes
inferred← citeshttps://doi.org/10.1007/s00018-023-04755-2openalex-snapshot
The forkhead box O3 (FOXO3): a key player in the regulation of ischemia and reperfusion injury
inferred← citeshttps://doi.org/10.1007/s00105-011-2136-7openalex-snapshot
Molekulare Ätiologie der Hautalterung
inferred← citeshttps://doi.org/10.1007/s00221-011-2905-7openalex-snapshot
Caenorhabditis elegans as a model organism to study APP function
inferred← citeshttps://doi.org/10.1007/s00335-020-09845-1openalex-snapshot
A scan for genes associated with cancer mortality and longevity in pedigree dog breeds
inferred← citeshttps://doi.org/10.1007/s00394-017-1460-9openalex-snapshot
Optimal nutrition and the ever-changing dietary landscape: a conference report
inferred← citeshttps://doi.org/10.1007/s00439-016-1709-zopenalex-snapshot
FUS-linked essential tremor associated with motor dysfunction in Drosophila
inferred← citeshttps://doi.org/10.1007/s10522-013-9470-3openalex-snapshot
Polymorphisms in the superoxidase dismutase genes reveal no association with human longevity in Germans: a case–control association study
inferred← citeshttps://doi.org/10.1007/s10522-013-9478-8openalex-snapshot
SIRT6, a protein with many faces
inferred← citeshttps://doi.org/10.1007/s10522-014-9527-yopenalex-snapshot
DAF-16 target identification in C. elegans: past, present and future
inferred← citeshttps://doi.org/10.1007/s10522-015-9589-5openalex-snapshot
Living long and ageing well: is epigenomics the missing link between nature and nurture?
inferred← citeshttps://doi.org/10.1007/s10522-016-9644-xopenalex-snapshot
Ageing with elegans: a research proposal to map healthspan pathways
inferred← citeshttps://doi.org/10.1007/s10522-016-9670-8openalex-snapshot
Insulin/insulin-like growth factor-1 signalling (IIS) based regulation of lifespan across species
inferred← citeshttps://doi.org/10.1007/s10522-016-9674-4openalex-snapshot
Keeping up with the Red Queen: the pace of aging as an adaptation
inferred← citeshttps://doi.org/10.1007/s10522-019-09824-3openalex-snapshot
Genetic background, epigenetic factors and dietary interventions which influence human longevity
inferred← citeshttps://doi.org/10.1007/s10522-025-10341-9openalex-snapshot
FOXO3a upregulates DNA repair activities by transcriptional activation of target genes and provides the resistance to gamma radiation and the extension of lifespan in mouse
inferred← citeshttps://doi.org/10.1007/s10753-015-0217-yopenalex-snapshot
FOXO3 rs12212067: T > G Association with Active Tuberculosis in Han Chinese Population
inferred← citeshttps://doi.org/10.1007/s10989-017-9648-7openalex-snapshot
The Effect of Anti-aging Peptides on Mechanical and Biological Properties of HaCaT Keratinocytes
inferred← citeshttps://doi.org/10.1007/s11033-012-2461-7openalex-snapshot
Ovine forkhead box class O 3 (FOXO3) gene variation and its association with lifespan
inferred← citeshttps://doi.org/10.1007/s11357-010-9146-8openalex-snapshot
Development of a serum profile for healthy aging
inferred← citeshttps://doi.org/10.1007/s11357-011-9340-3openalex-snapshot
Gene set analysis of GWAS data for human longevity highlights the relevance of the insulin/IGF-1 signaling and telomere maintenance pathways
inferred← citeshttps://doi.org/10.1007/s11357-011-9348-8openalex-snapshot
Remodelling of biological parameters during human ageing: evidence for complex regulation in longevity and in type 2 diabetes
inferred← citeshttps://doi.org/10.1007/s11357-011-9362-xopenalex-snapshot
Genomics of human health and aging
inferred← citeshttps://doi.org/10.1007/s11357-012-9408-8openalex-snapshot
Variations of the angiotensin II type 1 receptor gene are associated with extreme human longevity
inferred← citeshttps://doi.org/10.1007/s11357-013-9520-4openalex-snapshot
SIRT3 overexpression antagonizes high glucose accelerated cellular senescence in human diploid fibroblasts via the SIRT3–FOXO1 signaling pathway
inferred← citeshttps://doi.org/10.1007/s11357-013-9578-zopenalex-snapshot
Adjustment for smoking does not alter the FOXO3A association with longevity
inferred← citeshttps://doi.org/10.1007/s11357-014-9733-1openalex-snapshot
FNDC5 (irisin) gene and exceptional longevity: a functional replication study with rs16835198 and rs726344 SNPs
inferred← citeshttps://doi.org/10.1007/s11357-019-00098-8openalex-snapshot
Gastro-intestinal and oral microbiome signatures associated with healthy aging
inferred← citeshttps://doi.org/10.1007/s11357-020-00269-yopenalex-snapshot
Protein signatures from blood plasma and urine suggest changes in vascular function and IL-12 signaling in elderly with a history of chronic diseases compared with an age-matched healthy cohort
inferred← citeshttps://doi.org/10.1007/s11357-021-00431-0openalex-snapshot
Extreme longevity variants at the FOXO3 locus may moderate FOXO3 isoform levels
inferred← citeshttps://doi.org/10.1007/s11357-023-00740-6openalex-snapshot
Proteomic basis of mortality resilience mediated by FOXO3 longevity genotype
inferred← citeshttps://doi.org/10.1007/s11357-024-01147-7openalex-snapshot
Reduced insulin/IGF-1 signalling upregulates two anti-viral immune pathways, decreases viral load and increases survival under viral infection in C. elegans
inferred← citeshttps://doi.org/10.1007/s11357-024-01197-xopenalex-snapshot
The C. elegans Myc-family of transcription factors coordinate a dynamic adaptive response to dietary restriction
inferred← citeshttps://doi.org/10.1007/s11357-026-02229-4openalex-snapshot
Genome-wide association study and pathway analysis of healthy aging in Super Seniors
inferred← citeshttps://doi.org/10.1007/s11427-022-2161-3openalex-snapshot
The landscape of aging
inferred← citeshttps://doi.org/10.1007/s11427-023-2305-0openalex-snapshot
Biomarkers of aging
inferred← citeshttps://doi.org/10.1007/s11427-025-3242-5openalex-snapshot
Structural decomposition enables multi-omics dissection of common and organ-specific aging
inferred← citeshttps://doi.org/10.1007/s11684-024-1120-4openalex-snapshot
Factors involved in human healthy aging: insights from longevity individuals
inferred← citeshttps://doi.org/10.1007/s12011-013-9673-0openalex-snapshot
Effects of Soil Trace Elements on Longevity Population in China
inferred← citeshttps://doi.org/10.1007/s12033-023-00746-7openalex-snapshot
The Role of microRNA-23a-3p in the Progression of Human Aging Process by Targeting FOXO3a
inferred← citeshttps://doi.org/10.1007/s12035-011-8164-6openalex-snapshot
Ageing, Neuronal Connectivity and Brain Disorders: An Unsolved Ripple Effect
inferred← citeshttps://doi.org/10.1007/s12035-022-02904-5openalex-snapshot
P. edulis Extract Protects Against Amyloid-β Toxicity in Alzheimer’s Disease Models Through Maintenance of Mitochondrial Homeostasis via the FOXO3/DAF-16 Pathway
inferred← citeshttps://doi.org/10.1007/s12041-016-0677-3openalex-snapshot
Lack of association between rs10491334 in the CAMK4 gene and longevity in a Chinese population
inferred← citeshttps://doi.org/10.1007/s12268-014-0513-3openalex-snapshot
FoxO und die Alterung sterblicher und unsterblicher Organismen
inferred← citeshttps://doi.org/10.1007/s12311-019-01037-1openalex-snapshot
Current Opinions and Consensus for Studying Tremor in Animal Models
inferred← citeshttps://doi.org/10.1007/s12603-016-0690-5openalex-snapshot
Association between longevity and element levels in food and drinking water of typical Chinese longevity area
inferred← citeshttps://doi.org/10.1007/s12603-020-1392-6openalex-snapshot
Age-Dependent Changes in the Plasma Proteome of Healthy Adults
inferred← citeshttps://doi.org/10.1007/s13219-011-0035-1openalex-snapshot
Vieillissement et longévité : données récentes
inferred← citeshttps://doi.org/10.1007/s13277-014-2698-yopenalex-snapshot
Expression of microRNA-96 and its potential functions by targeting FOXO3 in non-small cell lung cancer
inferred← citeshttps://doi.org/10.1007/s15013-022-5043-3openalex-snapshot
Genetische und epigenetische Alterationen
inferred← citeshttps://doi.org/10.1007/s40520-015-0370-zopenalex-snapshot
A Chromosome 13 locus is associated with male-specific mortality in mice
inferred← citeshttps://doi.org/10.1016/b978-0-08-097086-8.34023-5openalex-snapshot
Old Age and Centenarians: The Human ‘Warranty Period’
inferred← citeshttps://doi.org/10.1016/b978-0-12-378638-8.00002-6openalex-snapshot
Role of the Somatotropic Axis in Mammalian Aging
inferred← citeshttps://doi.org/10.1016/b978-0-12-378638-8.00006-3openalex-snapshot
Aging of Stem Cells
inferred← citeshttps://doi.org/10.1016/b978-0-12-385101-7.00012-7openalex-snapshot
Aging, Nutrition and Lifestyle
inferred← citeshttps://doi.org/10.1016/b978-0-12-397803-5.00015-0openalex-snapshot
SIRT1 and Inflammaging in Chronic Obstructive Pulmonary Disease
inferred← citeshttps://doi.org/10.1016/b978-0-12-405926-9.00017-4openalex-snapshot
Developing a Systems Biology of Aging
inferred← citeshttps://doi.org/10.1016/b978-0-12-410529-4.00046-2openalex-snapshot
Genetic and Dietary Influences on Lifespan
inferred← citeshttps://doi.org/10.1016/b978-0-12-411596-5.00001-0openalex-snapshot
Longevity as a Complex Genetic Trait
inferred← citeshttps://doi.org/10.1016/b978-0-12-801238-3.11444-8openalex-snapshot
Regulation of Metabolism and Longevity
inferred← citeshttps://doi.org/10.1016/b978-0-12-801238-3.11451-5openalex-snapshot
Growth Hormone and Mammalian Aging
inferred← citeshttps://doi.org/10.1016/b978-0-12-801816-3.00005-4openalex-snapshot
Nutrition in the Elderly
inferred← citeshttps://doi.org/10.1016/b978-0-12-805417-8.00032-9openalex-snapshot
Eating Habits in Combating Disease
inferred← citeshttps://doi.org/10.1016/b978-0-12-809965-0.00010-0openalex-snapshot
Diverse Mechanisms of Transcriptional Regulation by the Vitamin D Receptor
inferred← citeshttps://doi.org/10.1016/b978-0-12-811060-7.00006-1openalex-snapshot
Living Long and Aging Well
inferred← citeshttps://doi.org/10.1016/b978-0-12-811353-0.00073-7openalex-snapshot
Genetics of Human Aging
inferred← citeshttps://doi.org/10.1016/b978-0-12-813955-4.00050-7openalex-snapshot
Genetic and dietary influences on life span
inferred← citeshttps://doi.org/10.1016/b978-0-12-815962-0.00001-9openalex-snapshot
Longevity as a complex genetic trait
inferred← citeshttps://doi.org/10.1016/b978-0-12-817193-6.00015-7openalex-snapshot
RNA and aging
inferred← citeshttps://doi.org/10.1016/b978-0-12-819404-1.00013-0openalex-snapshot
The forkhead box O family in insulin action and lipid metabolism
inferred← citeshttps://doi.org/10.1016/b978-0-12-819590-1.00002-1openalex-snapshot
Unraveling the mode of action of medicinal plants in delaying age-related diseases using model organisms
inferred← citeshttps://doi.org/10.1016/b978-0-323-85654-6.00057-5openalex-snapshot
The neurobiology of aging
inferred← citeshttps://doi.org/10.1016/b978-0-323-90581-7.00001-3openalex-snapshot
Plant bioactives, genes, and longevi
inferred← citeshttps://doi.org/10.1016/b978-0-323-91386-7.00043-xopenalex-snapshot
The diverse genomic mechanisms of action of the vitamin D receptor
inferred← citeshttps://doi.org/10.1016/b978-0-443-19176-3.00059-5openalex-snapshot
Genetic and dietary influences on life span
inferred← citeshttps://doi.org/10.1016/b978-0-443-27398-8.00014-9openalex-snapshot
Role of genetics and hormones in the differences in longevity between men and women
inferred← citeshttps://doi.org/10.1016/b978-0-443-33159-6.00006-0openalex-snapshot
Reverse aging through redox-sensitive transcription factors modulation
inferred← citeshttps://doi.org/10.1016/bs.abger.2023.06.001openalex-snapshot
Toward an ethical framework for geroscience?
inferred← citeshttps://doi.org/10.1016/bs.acr.2016.01.004openalex-snapshot
Sirtuins and the Estrogen Receptor as Regulators of the Mammalian Mitochondrial UPR in Cancer and Aging
inferred← citeshttps://doi.org/10.1016/bs.adgen.2015.06.002openalex-snapshot
Genetics and Pharmacology of Longevity
inferred← citeshttps://doi.org/10.1016/bs.ctdb.2017.10.001openalex-snapshot
FOXO3 and Exceptional Longevity: Insights From Hydra to Humans
inferred← citeshttps://doi.org/10.1016/bs.ctdb.2017.11.006openalex-snapshot
Stem Cells Seen Through the FOXO Lens: An Evolving Paradigm
inferred← citeshttps://doi.org/10.1016/bs.pbr.2025.01.001openalex-snapshot
Stress-induced neurodegeneration and behavioral alterations in Caenorhabditis elegans: Insights into the evolutionary conservation of stress-related pathways and implications for human health
inferred← citeshttps://doi.org/10.1016/j.advenzreg.2011.10.002openalex-snapshot
Regulation of autophagy by Forkhead box (FOX) O transcription factors
inferred← citeshttps://doi.org/10.1016/j.advnut.2023.05.014openalex-snapshot
Cell Survival, Death, and Proliferation in Senescent and Cancer Cells: the Role of (Poly)phenols
inferred← citeshttps://doi.org/10.1016/j.ahr.2026.100295openalex-snapshot
Chronological age and functional reserve, not blood pressure, predict loss of independence in Ogimi, Okinawa
inferred← citeshttps://doi.org/10.1016/j.ajog.2015.01.016openalex-snapshot
Advances in revealing the molecular targets downstream of oxidative stress–induced proapoptotic kinase signaling in diabetic embryopathy
inferred← citeshttps://doi.org/10.1016/j.archger.2024.105551openalex-snapshot
Cross-sectional and longitudinal associations between late-life depressive symptoms and cognitive deficits: 20-year follow-up of the Kuakini Honolulu-Asia aging study
inferred← citeshttps://doi.org/10.1016/j.arr.2009.10.006openalex-snapshot
Next-generation sequencing in aging research: Emerging applications, problems, pitfalls and possible solutions
inferred← citeshttps://doi.org/10.1016/j.arr.2010.03.003openalex-snapshot
No or only population-specific effect of PON1 on human longevity: A comprehensive meta-analysis
inferred← citeshttps://doi.org/10.1016/j.arr.2010.07.003openalex-snapshot
Longevity and lifespan control in mammals: Lessons from the mouse
inferred← citeshttps://doi.org/10.1016/j.arr.2010.08.001openalex-snapshot
The role of genetic variants in human longevity
inferred← citeshttps://doi.org/10.1016/j.arr.2010.09.002openalex-snapshot
Genetic variation in insulin/IGF-1 signaling pathways and longevity
inferred← citeshttps://doi.org/10.1016/j.arr.2014.08.002openalex-snapshot
Aging and cardiovascular diseases: The role of gene–diet interactions
inferred← citeshttps://doi.org/10.1016/j.arr.2014.10.005openalex-snapshot
Genetic factors associated with longevity: A review of recent findings
inferred← citeshttps://doi.org/10.1016/j.arr.2014.11.004openalex-snapshot
The systemic milieu as a mediator of dietary influence on stem cell function during ageing
inferred← citeshttps://doi.org/10.1016/j.arr.2014.12.008openalex-snapshot
Protein synthesis as an integral quality control mechanism during ageing
inferred← citeshttps://doi.org/10.1016/j.arr.2017.12.002openalex-snapshot
Insulin-like Growth Factor 1 (IGF-1) as a marker of cognitive decline in normal ageing: A review
inferred← citeshttps://doi.org/10.1016/j.arr.2020.101154openalex-snapshot
Fight to the bitter end: DNA repair and aging
inferred← citeshttps://doi.org/10.1016/j.arr.2021.101392openalex-snapshot
Centenarians as models of healthy aging: Example of REST
inferred← citeshttps://doi.org/10.1016/j.arr.2022.101621openalex-snapshot
Pharmaceutical and nutraceutical activation of FOXO3 for healthy longevity
inferred← citeshttps://doi.org/10.1016/j.arr.2026.103037openalex-snapshot
Blood flow and angiogenesis: Major mechanisms mediating healthful longevity
inferred← citeshttps://doi.org/10.1016/j.arr.2026.103176openalex-snapshot
Decoding human longevity: Genetic and molecular insights from accelerated to successful ageing
inferred← citeshttps://doi.org/10.1016/j.arr.2026.103343openalex-snapshot
Living beyond our evolutionary warranty: Why non-communicable diseases may be the inevitable costs of an extended lifespan
inferred← citeshttps://doi.org/10.1016/j.atg.2015.01.001openalex-snapshot
Genetics, lifestyle and longevity: Lessons from centenarians
inferred← citeshttps://doi.org/10.1016/j.bbadis.2017.09.006openalex-snapshot
Forward and reverse genetics approaches to uncover metabolic aging pathways in Caenorhabditis elegans
inferred← citeshttps://doi.org/10.1016/j.bbadis.2017.09.016openalex-snapshot
Drosophila as a model for ageing
inferred← citeshttps://doi.org/10.1016/j.bbadis.2017.09.017openalex-snapshot
Phenome and genome based studies into human ageing and longevity: An overview
inferred← citeshttps://doi.org/10.1016/j.bbadis.2018.01.026openalex-snapshot
Genetic cartography of longevity in humans and mice: Current landscape and horizons
inferred← citeshttps://doi.org/10.1016/j.bbadis.2018.08.039openalex-snapshot
Genetic and epigenetic regulation of human aging and longevity
inferred← citeshttps://doi.org/10.1016/j.bbagen.2009.07.010openalex-snapshot
Integrating evolutionary and molecular genetics of aging
inferred← citeshttps://doi.org/10.1016/j.bbalip.2014.08.004openalex-snapshot
FoxO1 at the nexus between fat catabolism and longevity pathways
inferred← citeshttps://doi.org/10.1016/j.bbamcr.2011.01.029openalex-snapshot
Mitochondrial longevity pathways
inferred← citeshttps://doi.org/10.1016/j.bbapap.2013.06.012openalex-snapshot
The protein–protein interaction network of the human Sirtuin family
inferred← citeshttps://doi.org/10.1016/j.bbr.2016.06.035openalex-snapshot
Conserved regulators of cognitive aging: From worms to humans
inferred← citeshttps://doi.org/10.1016/j.bbrc.2016.04.094openalex-snapshot
FoxO3a-mediated autophagy is down-regulated in the laforin deficient mice, an animal model for Lafora progressive myoclonus epilepsy
inferred← citeshttps://doi.org/10.1016/j.bbrc.2020.08.003openalex-snapshot
VPS-22/SNF8 regulates longevity via modulating the activity of DAF-16 in C. elegans
inferred← citeshttps://doi.org/10.1016/j.bcp.2019.02.012openalex-snapshot
Piperlongumine-induced nuclear translocation of the FOXO3A transcription factor triggers BIM-mediated apoptosis in cancer cells
inferred← citeshttps://doi.org/10.1016/j.beem.2013.05.016openalex-snapshot
Gender and longevity: Why do men die earlier than women? Comparative and experimental evidence
inferred← citeshttps://doi.org/10.1016/j.bej.2019.107237openalex-snapshot
Utilization of antimicrobial peptides, analogues and mimics in creating antimicrobial surfaces and bio-materials
inferred← citeshttps://doi.org/10.1016/j.bioactmat.2026.03.036openalex-snapshot
Epigenetic reprogramming periosteum promotes aging critical segmental bone defect repair via methylation remodeling
inferred← citeshttps://doi.org/10.1016/j.biocel.2022.106361openalex-snapshot
Roles of lipid metabolism and its regulatory mechanism in idiopathic pulmonary fibrosis: A review
inferred← citeshttps://doi.org/10.1016/j.biomag.2014.03.006openalex-snapshot
The biological time calendar
inferred← citeshttps://doi.org/10.1016/j.biopen.2017.01.002openalex-snapshot
Liver and Metformin: Lessons of a fructose diet in mice
inferred← citeshttps://doi.org/10.1016/j.biopha.2024.117716openalex-snapshot
Resveratrol alleviates heart failure by activating foxo3a to counteract oxidative stress and apoptosis
inferred← citeshttps://doi.org/10.1016/j.brainres.2022.147983openalex-snapshot
Identification of potential therapeutic and diagnostic characteristics of Alzheimer disease by targeting the miR-132-3p/FOXO3a-PPM1F axis in APP/PS1 mice
inferred← citeshttps://doi.org/10.1016/j.canlet.2012.09.017openalex-snapshot
Cancer genetics and genomics of human FOX family genes
inferred← citeshttps://doi.org/10.1016/j.cbpb.2014.01.004openalex-snapshot
FoxO/Daf-16 restored thrashing movement reduced by heat stress in Caenorhabditis elegans
inferred← citeshttps://doi.org/10.1016/j.ceb.2011.07.006openalex-snapshot
Death and dessert: nutrient signalling pathways and ageing
inferred← citeshttps://doi.org/10.1016/j.ceb.2012.08.009openalex-snapshot
Reprogramming aging and progeria
inferred← citeshttps://doi.org/10.1016/j.cell.2009.11.014openalex-snapshot
Reduced IGF-1 Signaling Delays Age-Associated Proteotoxicity in Mice
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